keyword
MENU ▼
Read by QxMD icon Read
search

Marker

keyword
https://www.readbyqxmd.com/read/28549377/biocompatibility-of-liposome-nanocarriers-in-the-rat-inner-ear-after-intratympanic-administration
#1
Jing Zou, Hao Feng, Rohit Sood, Paavo K J Kinnunen, Ilmari Pyykko
Liposome nanocarriers (LPNs) are potentially the future of inner ear therapy due to their high drug loading capacity and efficient uptake in the inner ear after a minimally invasive intratympanic administration. However, information on the biocompatibility of LPNs in the inner ear is lacking. The aim of the present study is to document the biocompatibility of LPNs in the inner ear after intratympanic delivery. LPNs with or without gadolinium-tetra-azacyclo-dodecane-tetra-acetic acid (Gd-DOTA) were delivered to the rats through transtympanic injection...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28549370/assessment-of-the-influence-of-key-abiotic-factors-on-the-alternative-microcystin-degradation-pathway-s-mlr-a-detailed-comparison-with-the-mlr-route-mlr
#2
Jesús Morón-López, Lucía Nieto-Reyes, Rehab El-Shehawy
Cyanobacterial proliferation and toxin production in water bodies around the world have led to global concern about the control of these issues. Indigenous bacteria have been shown to degrade the cyanotoxin microcystin (MC) in natural environments. The mlr cluster has been widely used as a marker for microcystin biodegradation; however, recent studies have shown that alternative pathway(s) also contribute to the natural removal of MCs in the ecosystem. The main objective of this study is to provide initial insights concerning how key abiotic factors affect the rate of MC biodegradation via alternative pathway(s) and to provide a detailed comparison with the mlr(+) pathway...
May 22, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28549347/the-roles-of-ing5-in-gliomas-a-good-marker-for-tumorigenesis-and-a-potential-target-for-gene-therapy
#3
Shuang Zhao, Zhi-Juan Zhao, Hao-Yu He, Ji-Cheng Wu, Xiao-Qing Ding, Lei Yang, Ning Jia, Zhi-Jie Li, Hua-Chuan Zheng
To elucidate the anti-tumor effects and molecular mechanisms of ING5 on glioma cells, we overexpressed it in U87 cells, and examined the phenotypes and their relevant molecules. It was found that ING5 overexpression suppressed proliferation, energy metabolism, migration, invasion, and induced G2/M arrest, apoptosis, dedifferentiation, senescence, mesenchymal- epithelial transition and chemoresistance to cisplatin, MG132, paclitaxel and SAHA in U87 cells. There appeared a lower expression of N-cadherin, Twist, Slug, Zeb1, Zeb2, Snail, Ac-H3, Ac-H4, Cdc2, Cdk4 and XIAP, but a higher expression of Claudin 1, Histones 3 and 4, p21, p53, Bax, β-catenin, PI3K, Akt, and p-Akt in ING5 transfectants...
May 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28549341/cdk1-interacts-with-iaspp-to-regulate-colorectal-cancer-cell-proliferation-through-p53-pathway
#4
Wei Gan, Hua Zhao, Tiegang Li, Kuijie Liu, Jiangsheng Huang
CDK1 (cyclin-dependent kinase 1) is a critical regulator of the G2-M checkpoint. CDK1 is considered a possible target for cancer treatment. In addition to CDK1, iASPP plays essential role in maintaining cancer cell proliferation. In the present study, we monitored the expression of CDK1 and iASPP at mRNA and protein levels in CRC tissues and cell lines; we also predicted that iASPP protein might interact with CDK1 protein. By performing GST pull-down assay and Co-IP assay, we confirmed the interaction of CDK1 and iASPP protein...
May 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28549318/brain-neurodevelopmental-markers-related-to-the-deficit-subtype-of-schizophrenia
#5
Tsutomu Takahashi, Yoichiro Takayanagi, Yumiko Nishikawa, Mihoko Nakamura, Yuko Komori, Atsushi Furuichi, Mikio Kido, Daiki Sasabayashi, Kyo Noguchi, Michio Suzuki
Deficit schizophrenia is a homogeneous subtype characterized by a trait-like feature of primary and prominent negative symptoms, but the etiologic factors related to this specific subtype remain largely unknown. This magnetic resonance imaging study aimed to examine gross brain morphology that probably reflects early neurodevelopment in 38 patients with deficit schizophrenia, 37 patients with non-deficit schizophrenia, and 59 healthy controls. Potential brain neurodevelopmental markers investigated in this study were the adhesio interthalamica (AI), cavum septi pellucidi (CSP), and surface morphology (i...
May 20, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28549300/evaluation-of-the-in-vitro-effect-of-boldo-and-meadowsweet-plant-extracts-on-the-expression-of-antimicrobial-peptides-and-inflammatory-markers-in-canine-keratinocytes
#6
Domenico Santoro, Kim Ahrens, Ryan Vesny, Christelle Navarro, Hugues Gatto, Rosanna Marsella
Dogs with allergies are prone to skin infections and treatments/preventatives to boost innate immune-defenses are beneficial. The aim of this study was to evaluate the effects of Boldo and Meadowsweet extracts on the expression of β-defensins (cBD), cathelicidin (cCath), and pro-inflammatory cytokines in canine keratinocyte. This study had two phases. Phase I evaluated mRNA expression of cBD103 and cCath, and secretion of cCath, IL-8 and TNF-α by keratinocytes harvested from healthy (n=5) and atopic (n=5) age-matched beagles exposed to Boldo (2% to 0...
May 17, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28549293/automated-recognition-of-the-pericardium-contour-on-processed-ct-images-using-genetic-algorithms
#7
É O Rodrigues, L O Rodrigues, L S N Oliveira, A Conci, P Liatsis
This work proposes the use of Genetic Algorithms (GA) in tracing and recognizing the pericardium contour of the human heart using Computed Tomography (CT) images. We assume that each slice of the pericardium can be modelled by an ellipse, the parameters of which need to be optimally determined. An optimal ellipse would be one that closely follows the pericardium contour and, consequently, separates appropriately the epicardial and mediastinal fats of the human heart. Tracing and automatically identifying the pericardium contour aids in medical diagnosis...
May 17, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28549278/effects-of-varenicline-and-nicotine-replacement-therapy-on-arterial-elasticity-endothelial-glycocalyx-and-oxidative-stress-during-a-3-month-smoking-cessation-program
#8
Ignatios Ikonomidis, Margarita Marinou, Dimitrios Vlastos, Kallirhoe Kourea, Ioanna Andreadou, Nikolaos Liarakos, Helen Triantafyllidi, George Pavlidis, Elias Tsougos, John Parissis, John Lekakis
BACKGROUND AND AIMS: The effects of medically-aided smoking cessation on vascular function and oxidative stress are not fully clarified. METHODS: One hundred eighty-eight current smokers were randomized to varenicline or nicotine replacement treatment (NRT) for a 3-month period. We assessed: (a) augmentation index (Aix) and pulse wave velocity (PWV); (b) perfusion boundary region (PBR) of sublingual microvasculature (range:5-25 μm), an index of the endothelial glycocalyx thickness, using Sideview, Darkfield imaging; (c) the exhaled CO; and (d) the malondialdehyde (MDA) and protein carbonyls (PC) plasma levels, as markers of oxidative stress, at baseline and after 3 and 12 months...
May 13, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28549276/different-seizure-onset-patterns-in-mesiotemporal-lobe-epilepsy-have-a-distinct-interictal-signature
#9
Birgit Frauscher, Nicolás von Ellenrieder, François Dubeau, Jean Gotman
OBJECTIVE: Experimental research demonstrated that distinct underlying mechanisms go along with different seizure-onset patterns on EEG. These different mechanisms may reflect different tissue abnormalities which, we hypothesize, could also be reflected in morphological differences in the interictal epileptic and background EEG activity. METHODS: We searched our database of intracranial EEG recordings for mesiotemporal lobe epilepsy patients with either predominant low-voltage fast activity (LVF) or periodic spiking (PS)...
May 9, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28549259/purinergic-2x7-receptor-activation-regulates-wnt-signaling-in-human-mandibular-derived-osteoblasts
#10
Pimrumpai Rochanakit Sindhavajiva, Panunn Sastravaha, Mansuang Arksornnukit, Prasit Pavasant
OBJECTIVE: Purinergic 2X7 receptor (P2X7R) activation modulates in vitro mineralization by primary rat and human osteoblasts. However, the detailed mechanism of how P2X7R activation affects primary human osteoblasts remains unclear. The aim of this study was to investigate the effect of P2X7R activation on human mandibular-derived osteoblast (hMOB) differentiation. DESIGN: Primary human osteoblasts were obtained from non-pathologic mandibular bone from healthy patients...
May 18, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28549207/morphological-descriptors-and-issr-molecular-markers-in-the-evaluation-of-genetic-variability-of-tectona-grandis-genotypes
#11
A M Chimello, J G Jesus, P E Teodoro, A A B Rossi, K L Araújo, T N Marostega, L G Neves, M A A Barelli
This study aimed to evaluate the genetic variability of the teak germplasm bank, using morphological traits and inter-simple sequence repeat molecular markers. Thirty clones were evaluated in a randomized complete block design with three replicates, and each plot was composed of three plants. A joint analysis of quantitative and qualitative variables was performed using the Gower algorithm. Quantitative, qualitative, and molecular variables were analyzed simultaneously using the Ward-MLM procedure. There is genetic variability among the 30 teak genotypes studied, considering the quantitative, qualitative, and molecular variables by the Ward-MLM statistical procedure...
May 25, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28549206/assessment-of-allelic-diversity-among-drought-resistant-cotton-genotypes-using-microsatellite-markers
#12
A Javaid, F S Awan, F M Azhar, I A Khan
Drought, in conjunction with high temperature, is an important environmental constraint to cotton production. Development of cotton varieties with increased tolerance against adverse environmental conditions has been proposed as effective strategy for ensuring reliable yields. In the present study, 30 simple sequence repeat (SSR) primers were used to estimate genetic divergence among 22 cotton genotypes for drought stress tolerance. Genetic diversity is a prerequisite for developing drought resistant cotton genotypes...
May 25, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28549200/effects-of-cell-death-inducing-dff45-like-effector-b-on-meat-quality-traits-in-berkshire-pigs
#13
G E Yu, S Kwon, J H Hwang, S M An, D H Park, D G Kang, T W Kim, I-S Kim, H C Park, J Ha, C W Kim
Cell death-inducing DFF45-like effector (CIDE) B is a member of the CIDE family of apoptosis-inducing factors. In the present study, we detected a single nucleotide polymorphism (SNP), c.414G>A, which corresponds to the synonymous SNP 414Arg, in CIDE-B in the Berkshire pigs. We also analyzed the relationships between the CIDE-B SNP and various meat quality traits. The SNP was significantly associated with post-mortem pH24h, water-holding capacity (WHC), fat content, protein content, drip loss, post-mortem temperature at 12 h (T12) and 24 h (T24) in a co-dominant model (P < 0...
May 25, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28549185/visibility-and-persistence-of-marker-dyes-and-effect-on-the-quality-and-mating-competitiveness-of-mass-reared-flies-diptera-tephritidae-anastrepha-obliqua-and-bisexual-and-genetic-sexing-tapachula-7-strains-of-a-ludens
#14
José Arredondo, Lia Ruiz, Gladis López, Francisco Díaz-Fleischer
Fluorescent dyes are commonly used in the sterile insect technique (SIT) for marking insects for a proper identification after recapture. However, the quality of the mark must be balanced against insect performance, because dyes can negatively affect some parameters of insect performance and reduce their effectiveness in control with the SIT. We determined the visibility and persistence and the effect of dyes on the quality of Anastrepha obliqua (Macquart) and Anastrepha ludens (Loew) (bisexual and genetic sexing strains) by testing four concentrations of a dye (Day-Glo) from 0 to 2...
May 26, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28549123/working-conditions-in-the-explanation-of-occupational-inequalities-in-sickness-absence-in-the-french-sumer-study
#15
Isabelle Niedhammer, Thomas Lesuffleur, Sarah Memmi, Jean-François Chastang
: Explanations of social inequalities in sickness absence are lacking in the literature. Our objectives were to evaluate the contribution of various occupational exposures in explaining these inequalities in a national representative sample of employees. : The study was based on the cross-sectional sample of the SUMER 2010 survey that included 46 962 employees, 26 883 men and 20 079 women. Both sickness absence spells and days within the last 12 months, as health indicators, were studied. Occupation was used as a marker of social position...
May 25, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28549095/klf4-plays-an-essential-role-in-corneal-epithelial-homeostasis-by-promoting-epithelial-cell-fate-and-suppressing-epithelial-mesenchymal-transition
#16
Anil Tiwari, Chelsea L Loughner, Sudha Swamynathan, Shivalingappa K Swamynathan
Purpose: The purpose of this study was to test the hypothesis that KLF4 promotes corneal epithelial (CE) cell fate by suppressing the epithelial-mesenchymal transition (EMT), using spatiotemporally regulated CE-specific ablation of Klf4 in Klf4Δ/ΔCE (Klf4LoxP/LoxP/Krt12rtTA/rtTA/Tet-O-Cre) mice. Methods: CE-specific ablation of Klf4 was achieved by feeding Klf4Δ/ΔCE mice with doxycycline chow. The wild-type (WT; normal chow-fed littermates) and the Klf4Δ/ΔCE histology was compared by hematoxylin and eosin-stained sections; EMT marker expression was quantified by quantitative PCR, immunoblots, and immunofluorescent staining; and wound healing rate was measured by CE debridement using Algerbrush...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28549088/quantitative-association-between-peripapillary-bruch-s-membrane-shape-and-intracranial-pressure
#17
Amulya Gampa, Gautam Vangipuram, Zainab Shirazi, Heather E Moss
Purpose: The purpose of this study was to determine if there is a quantitative relationship between chronic intracranial pressure (ICP) and peripapillary Bruch's membrane (pp-BM) shape and to determine whether change in pp-BM shape can be detected within 1 hour after ICP lowering by lumbar puncture (LP). Methods: In this study, 30° nasal-temporal optical coherence tomography B-scans were obtained within 1 hour before and after LP in 39 eyes from 20 patients (age = 23-86 years, 75% female, ICP [opening pressure] = 10-55 cm H2O)...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28549087/thalamic-alterations-remote-to-infarct-appear-as-focal-iron-accumulation-and-impact-clinical-outcome
#18
Grégory Kuchcinski, Fanny Munsch, Renaud Lopes, Antoine Bigourdan, Jason Su, Sharmila Sagnier, Pauline Renou, Jean-Pierre Pruvo, Brian K Rutt, Vincent Dousset, Igor Sibon, Thomas Tourdias
Thalamic alterations have been observed in infarcts initially sparing the thalamus but interrupting thalamo-cortical or cortico-thalamic projections. We aimed at extending this knowledge by demonstrating with in vivo imaging sensitive to iron accumulation, one marker of neurodegeneration, that (i) secondary thalamic alterations are focally located in specific thalamic nuclei depending on the initial infarct location; and (ii) such secondary alterations can contribute independently to the long-term outcome. To tackle this issue, 172 patients with an infarct initially sparing the thalamus were prospectively evaluated clinically and with magnetic resonance imaging to quantify iron through R2* map at 24-72 h and at 1-year follow-up...
May 25, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28549077/clinical-criteria-for-subtyping-parkinson-s-disease-biomarkers-and-longitudinal-progression
#19
Seyed-Mohammad Fereshtehnejad, Yashar Zeighami, Alain Dagher, Ronald B Postuma
Parkinson's disease varies widely in clinical manifestations, course of progression and biomarker profiles from person to person. Identification of distinct Parkinson's disease subtypes is of great priority to illuminate underlying pathophysiology, predict progression and develop more efficient personalized care approaches. There is currently no clear way to define and divide subtypes in Parkinson's disease. Using data from the Parkinson's Progression Markers Initiative, we aimed to identify distinct subgroups via cluster analysis of a comprehensive dataset at baseline (i...
May 25, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28549038/use-of-smooth-muscle-myosin-heavy-chain-as-an-effective-marker-of-follicular-dendritic-cells
#20
Ioannis Ioannidis, Javier A Laurini
Smooth muscle myosin heavy chain (SMMHC) is a major structural component of the contractile apparatus in smooth muscle cells. Even though it is considered a relatively specific marker for terminal smooth muscle cell differentiation, expression in other cell types such as follicular dendritic cells (FDCs) has rarely been reported. To determine whether SMMHC represents an effective FDC marker in lymphoid tissues, we compared the immunohistochemical results for SMMHC with those of the traditional FDC markers podoplanin (D2-40) and CD21...
May 25, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
keyword
keyword
19305
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"