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https://www.readbyqxmd.com/read/27501707/dihydromyricetin-ameliorates-3np-induced-behavioral-deficits-and-striatal-injury-in-rats
#1
Shuhua Mu, Youlan Li, Bingbing Liu, Weiping Wang, Si Chen, Jiajia Wu, Lisi OuYang, Yaxi Zhu, Keyi Li, Mali Zhan, Zongwei Liu, Yu Jia, Yuxin Ma, Wanlong Lei
Oxidative stress is closely involved in neurodegenerative diseases. The present study aimed to examine the effect of anti-oxidant DHM (dihydromyricetin) on 3NP (3-nitropropionic acid) -induced behavioral deficits of experimental rats and striatal histopathological injury by using behavioral, imaging, biochemistry, histochemistry and molecular biology technologies. The experimental results showed that both motor dysfunctions and learning and memory impairments induced by 3NP were significantly reduced after DHM treatment...
October 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/24231358/whole-brain-circuit-dissection-in-free-moving-animals-reveals-cell-specific-mesocorticolimbic-networks
#2
Michael Michaelides, Sarah Ann R Anderson, Mala Ananth, Denis Smirnov, Panayotis K Thanos, John F Neumaier, Gene-Jack Wang, Nora D Volkow, Yasmin L Hurd
The ability to map the functional connectivity of discrete cell types in the intact mammalian brain during behavior is crucial for advancing our understanding of brain function in normal and disease states. We combined designer receptor exclusively activated by designer drug (DREADD) technology and behavioral imaging with ╬╝PET and [18F]fluorodeoxyglucose (FDG) to generate whole-brain metabolic maps of cell-specific functional circuits during the awake, freely moving state. We have termed this approach DREADD-assisted metabolic mapping (DREAMM) and documented its ability in rats to map whole-brain functional anatomy...
December 2013: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/22977872/effect-of-tripeptide-lys-glu-asp-on-physiological-activity-of-neuroimmunoendocrine-system-cells
#3
N I Chalisova, N G Lopatina, N G Kamishev, N S Linkova, E A Koncevaya, A V Dudkov, L S Kozina, V Kh Khavinson, Yu S Titkov
Tripeptide Lys-Glu-Asp stimulates proliferation and inhibits apoptosis in organotypic cultures of neuroimmunoendocrine system cells. Lys-Glu-Asp accelerates cell renewal processes (decrease of apoptosis marker p53 and increase of proliferation marker Ki-67) in the pineal gland; this effect is more pronounced in cultures derived from old animals than in young cultures. The tripeptide induces the expression of low-differentiated lymphocyte marker CD5 and macrophage marker CD68, but in "old" cultures this effect is less pronounced than in "young" ones...
August 2012: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/22285422/basal-anxiety-like-behavior-predicts-differences-in-dendritic-morphology-in-the-medial-prefrontal-cortex-in-two-strains-of-rats
#4
Melinda M Miller, John H Morrison, Bruce S McEwen
Basal differences in the brain may account for why some individuals are more vulnerable to stress than others. Although trait anxiety behavior varies greatly in human populations, most animal models of anxiety disorders tend to focus on the development of anxiety after a stressful experience. In this study, adult male Sprague-Dawley and Lewis rats were grouped according to baseline anxiety-like behavior in the open field, measured by time spent and distance traveled in the center. Individuals that fell one standard deviation above and below the mean, approximately the top and bottom 15%, were selected for the Low and High Anxiety groups...
April 1, 2012: Behavioural Brain Research
https://www.readbyqxmd.com/read/21284950/gastric-distention-induced-functional-magnetic-resonance-signal-changes-in-the-rodent-brain
#5
D K Min, U I Tuor, P K Chelikani
Investigating the localization of gastric sensation within the brain is important for understanding the neural correlates of satiety. Previous rodent studies have identified the brain-stem and hypothalamus as key mediators of gastric distention-induced satiation. Although, recent blood oxygen level-dependent functional magnetic resonance imaging (BOLD fMRI) studies in humans have identified a role for higher cortico-limbic structures in mediating the satiation effects of gastric distention, the role of these regions in rodents remains to be characterized...
April 14, 2011: Neuroscience
https://www.readbyqxmd.com/read/21219928/assessment-of-i-p-injection-of-18f-fallypride-for-behavioral-neuroimaging-in-rats
#6
Karmen K Yoder, Bruce H Mock, Qi-Huang Zheng, Brian P McCarthy, Amanda A Riley, Gary D Hutchins
Great progress has been made toward using small animal PET to assess neurochemical changes during behavior. [(18)F]fallypride (FAL) is a D(2)/D(3) antagonist that is sensitive to changes in endogenous dopamine, and, in theory, could be used to assess changes in dopamine during behavioral paradigms. Tail vein injections of tracer require restraint in awake animals, and catheter implantation is invasive and can cause logistical problems. Thus, administering tracer with i.p. injections (which are well-tolerated by rodents) would be preferable...
March 15, 2011: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/20734425/functional-and-histological-improvement-of-the-injured-spinal-cord-following-transplantation-of-schwann-cells-transfected-with-nrg1-gene
#7
Jifei Zhang, Fusheng Zhao, Geng Wu, Yuezhen Li, Xiudong Jin
In this study, we implanted Schwann cells (SCs) transfected with Neuregulin 1 (NRG1) gene into rats with hemisection spinal cord injury, determined its effects on the repair of spinal cord injury and investigated the underlying mechanisms. Primary SCs were cultured, purified, and transfected with NRG1 gene. SCs and SCs transfected with NRG1 gene were implanted, respectively, into rats with hemisection spinal cord injury. Behavior, imaging, electrophysiology, and immuno-histological analyses were performed to evaluate the effect of NRG1 gene-transfected SCs on the repair of spinal cord injury...
November 2010: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/19770051/3d-mapping-of-somatotopic-reorganization-with-small-animal-functional-mri
#8
Xin Yu, Shumin Wang, Der-Yow Chen, Stephen Dodd, Artem Goloshevsky, Alan P Koretsky
There are few in vivo noninvasive methods to study neuroplasticity in animal brains. Functional MRI (fMRI) has been developed for animal brain mapping, but few fMRI studies have analyzed functional alteration due to plasticity in animal models. One major limitation is that fMRI maps are characterized by statistical parametric mapping making the apparent boundary dependent on the statistical threshold used. Here, we developed a method to characterize the location of center-of-mass in fMRI maps that is shown not to be sensitive to statistical threshold...
January 15, 2010: NeuroImage
https://www.readbyqxmd.com/read/18279841/imaging-brain-activation-in-nicotine-sensitized-rats
#9
Zhixin Li, Joseph R DiFranza, Robert J Wellman, Praveen Kulkarni, Jean A King
Our purpose was to determine if sensitization to nicotine could be assessed using functional magnetic resonance imaging (fMRI) with BOLD contrast. Sensitization describes a phenomenon whereby subsequent doses of a drug produce greater responses than the initial dose. Robust locomotor sensitization was demonstrated in adult male Sprague-Dawley rats by the daily administration of nicotine 0.4 mg/kg over 5 days. In parallel experiments, brain activity was monitored using fMRI in animals receiving their first dose (acute) or fifth dose of nicotine (sensitized) and appropriate saline controls...
March 14, 2008: Brain Research
https://www.readbyqxmd.com/read/17268026/optimizing-experimental-protocols-for-quantitative-behavioral-imaging-with-18f-fdg-in-rodents
#10
Wynne K Schiffer, Martine M Mirrione, Stephen L Dewey
UNLABELLED: Small-animal PET provides the opportunity to image brain activation during behavioral tasks in animal models of human conditions. The present studies aimed to simplify behavioral imaging procedures without a loss of quantitation by using an intraperitoneal route of administration (no cannulation, no anesthesia) and using a standardized uptake value (SUV) to reduce scan duration. METHODS: Sixteen animals with carotid artery cannulations were studied with 18F-FDG small-animal PET accompanied by serial arterial blood sampling...
February 2007: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/17012064/behavioral-tests-for-preclinical-intervention-assessment
#11
REVIEW
Timothy Schallert
Select functional outcome tests commonly used for evaluating sensorimotor and cognitive capacity in rodents with focal intracerebral ischemic or hemorrhagic injury are described, along with upgrades and issues of concern for translational research. An emphasis is placed on careful quantitative and qualitative assessment of acute and long-term behavioral deficits, and on avoidance of frequent pitfalls. Methods for detecting different degrees of injury and treatment-related improvements are included. Determining the true potential of an intervention requires a set of behavioral analyses that can monitor compensatory learning...
October 2006: NeuroRx: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/12002520/validation-of-a-behavioral-recording-automated-system-in-the-elevated-plus-maze-test
#12
COMPARATIVE STUDY
C Torres, M D Escarabajal
The elevated plus-maze test has been widely used for screening of anxiolytic drugs and for exploring neurobiological bases of anxiety. In this study, we validated a new automated system that enables to record exploratory behavior in the elevated plus-maze test. This system, called cyberplus, consisted of ten pairs of photoelectric cells strategically located in several parts of the apparatus, and seemed to be sensitive to the position of the animal's forepaws, so it would yield scores in anxiety measurements and locomotor activity similar to those obtained by following the traditional procedure, that is, by analyzing videotapes by experienced observers...
March 1, 2002: Life Sciences
https://www.readbyqxmd.com/read/9334943/applications-of-multimedia-computers-and-video-mixing-to-neuroethology
#13
B Rasnow, C Assad, M J Hartmann, J M Bower
Inexpensive multimedia computers offer new possibilities for mixing video and computer images, videotaping these mixed images, and extracting quantitative data from videotape. In this paper we describe methods for mixing images from a video camera and a Macintosh computer display using chroma keying, and we describe a simple circuit for analog video mixing and frame-counting. We present three applications of these video mixing methods to our neurophysiological and behavioral research with awake, behaving animals...
September 5, 1997: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/8982980/a-new-video-path-analyzer-to-monitor-travel-distance-rearing-and-stereotypic-movement-of-rats
#14
COMPARATIVE STUDY
W H Pan, C R Lee, L H Lim
A new video path analyzer, described herein, monitors travel distance, rearing, stereotypic movement, rotation, and speed of rats simultaneously. The video path analyzer was equipped with a cage (black background, 50 cm long x 50 cm wide x 50 cm high), camera, television screen, computer, and printer. A detailed description of this equipment is included. While studying the known activating effects of d-amphetamine on rats' behavior, we also evaluated the equipment for its maximum and accurate contribution to this study...
December 1996: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/7990511/a-new-method-to-quantify-behavioral-attention-to-a-stimulus-object-in-a-modified-open-field
#15
H Dai, R J Carey
A new method was developed to measure locomotion and attention to a stimulus object in a typical open-field environment using a video image-analyzer system. A computer-generated central zone (CZ) composing 1/9 of the open-field floor area was monitored independently from the rest of the area. Intermittently, a 4 x 4 x 2 cm object was placed in the CZ. In 10 min test sessions, the presence of the object repeatedly and consistently increased the animal's time spent in the CZ as compared with tests when the object was absent...
July 1994: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/3185963/effect-of-apamin-on-local-rates-of-glucose-utilization-in-the-brain-and-the-spinal-cord-in-rats
#16
S Cohen, M Kadekaro, M L Terrell, H Gary, H M Eisenberg
The effects of apamin on local rates of glucose utilization in the brain and spinal cord were studied employing the quantitative autoradiographic deoxyglucose method. Forty-five to 60 min after administration of apamin the animals lost exploratory behavior, remaining completely immobile, with the 4 limbs overextended, unresponsive to auditory stimuli. Out of 30 neural structures examined, glucose utilization was significantly decreased in the cochlear n., superior olivary n., lateral lemniscus, inferior colliculus, medial geniculate body, fastigial n...
September 12, 1988: Neuroscience Letters
https://www.readbyqxmd.com/read/1963108/brain-stimulation-induced-feeding-alters-regional-opioid-receptor-binding-in-the-rat-an-in-vivo-autoradiographic-study
#17
E A Stein, K D Carr, E J Simon
Although opioid antagonists block feeding behavior in a variety of animal models, the number and identity of CNS regions in which the inferred endogenous opioid activity mediates feeding have yet to be established. Furthermore, it is not yet clear whether the opioid activity that sustains feeding is a concomitant of the appetitive motivational state or the consummatory response. In an effort to address these issues, an in vivo autoradiographic method was used to visualize CNS regional changes in opioid release during appetitively motivating electrical stimulation in the lateral hypothalamus (ESLH) and during consummatory behavior elicited by such stimulation...
November 19, 1990: Brain Research
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