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https://www.readbyqxmd.com/read/28706558/qiliqiangxin-enhances-cardiac-glucose-metabolism-and-improves-diastolic-function-in-spontaneously-hypertensive-rats
#1
Jingfeng Wang, Zhiming Li, Yanyan Wang, Jingjing Zhang, Weipeng Zhao, Mingqiang Fu, Xueting Han, Jingmin Zhou, Junbo Ge
Cardiac diastolic dysfunction has emerged as a growing type of heart failure. The present study aims to explore whether Qiliqiangxin (QL) can benefit cardiac diastolic function in spontaneously hypertensive rat (SHR) through enhancement of cardiac glucose metabolism. Fifteen 12-month-old male SHRs were randomly divided into QL-treated, olmesartan-treated, and saline-treated groups. Age-matched WKY rats served as normal controls. Echocardiography and histological analysis were performed. Myocardial glucose uptake was determined by (18)F-FDG using small-animal PET imaging...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28692851/a-simple-device-to-convert-a-small-animal-pet-scanner-into-a-multi-sample-tissue-and-injection-syringe-counter
#2
Michael V Green, Jurgen Seidel, Peter L Choyke, Elaine M Jagoda
INTRODUCTION: We describe a simple fixture that can be added to the imaging bed of a small-animal PET scanner that allows for automated counting of multiple organ or tissue samples from mouse-sized animals and counting of injection syringes prior to administration of the radiotracer. The combination of imaging and counting capabilities in the same machine offers advantages in certain experimental settings. METHODS: A polyethylene block of plastic, sculpted to mate with the animal imaging bed of a small-animal PET scanner, is machined to receive twelve 5-ml containers, each capable of holding an entire organ from a mouse-sized animal...
June 3, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28689313/-137-cs-transmission-imaging-and-segmented-attenuation-corrections-in-a-small-animal-pet-scanner
#3
Ying-Hwey Nai, Takayuki Ose, Miho Shidahara, Hiroshi Watabe
Attenuation correction (AC) is required for accurate quantitative evaluation of small animal PET data. Our objective was to compare three AC methods in the small animal Clairvivo-PET scanner. The three AC methods involve applying attenuation coefficient maps generated by simulating a cylindrical map (SAC), segmenting the emission data (ESAC), and segmenting the transmission data (TSAC), imaged using a (137)Cs single-photon source. Investigation was carried out using a 65 mm uniform cylinder and an NEMA NU4 2008 mouse phantom, filled with water or tungsten liquid, to mimic bone...
July 8, 2017: Radiological Physics and Technology
https://www.readbyqxmd.com/read/28682792/performance-of-a-high-resolution-depth-encoding-pet-detector-using-barium-sulfate-reflector
#4
Zhonghua Kuang, Xiaohui Wang, Cheng Li, Xinhan Deng, Kai Feng, Zhanli Hu, Xin Fu, Ning Ren, Xianming Zhang, Yunfei Zheng, Dong Liang, Xin Liu, Hairong Zheng, Yongfeng Yang
Small animal positron emission tomography (PET) is a well-established imaging modality in preclinical biomedical research. The performance of current small animal PET scanners is mainly limited by the detector performance and depth-encoding detectors are required to simultaneously achieve high spatial resolution and high sensitivity. In this work, the performance of a high-resolution dual-ended readout lutetium-yttrium oxyorthosilicate (LYSO) array using barium sulfate powder (BaSO4) as the inter-crystal reflector was measured for the first time and compared to that of a LYSO array using the most commonly used enhanced specular reflector (ESR)...
July 6, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28653240/immunopet-imaging-of-%C3%AE-v%C3%AE-6-expression-using-an-engineered-anti-%C3%AE-v%C3%AE-6-cys-diabody-site-specifically-radiolabeled-with-cu-64-considerations-for-optimal-imaging-with-antibody-fragments
#5
Jason B White, Lina Y Hu, David L Boucher, Julie L Sutcliffe
PURPOSE: Increased expression of the αvβ6 integrin correlates with advanced tumor grade and poor clinical outcome, identifying αvβ6 as a prognostic indicator and an attractive target for molecular imaging. This work investigated the ability of a disulfide-stabilized [(64)Cu]NOTA-αvβ6 cys-diabody to image αvβ6 expression in vivo using a nu/nu mouse model bearing human melanoma xenografts and positron-emission tomography. PROCEDURES: Small-animal positron emission tomography (PET) imaging, quantitative ROI analysis, and ex vivo biodistribution were conducted to ascertain tumor uptake and organ distribution of the [(64)Cu]NOTA-αvβ6 cys-diabody...
June 26, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28616954/surface-charge-and-particle-size-determine-the-metabolic-fate-of-dendritic-polyglycerols
#6
Kritee Pant, Johanna Pufe, Kristof Zarschler, Ralf Bergmann, Jörg Steinbach, Sabine Reimann, Rainer Haag, Jens Pietzsch, Holger Stephan
Dendritic polyglycerols (dPG) are water soluble, polyether-based nanomaterials which hold great potential in diagnostic as well as therapeutic applications. In order to translate them for in vivo applications, a systematic assessment regarding their cell and tissue interactions as well as their metabolic fate in vivo is a crucial step. Herein, we explore the structure-activity relationship of three different sizes (ca. 3, 5, and 10 nm) of neutral dendritic polyglycerol (dPG) and their corresponding negatively charged sulfate analogs (dPGS) on their in vitro and in vivo characteristics...
June 29, 2017: Nanoscale
https://www.readbyqxmd.com/read/28598691/development-of-68-ga-scn-dota-capsaicin-as-an-imaging-agent-targeting-apoptosis-and-cell-cycle-arrest-in-breast-cancer
#7
Jun Young Lee, Sang-Yeun Lee, Gun Gyun Kim, Min Goo Hur, Seung Dae Yang, Jeong-Hoon Park, Sang Wook Kim
(68)Ga-labeled capsaicin using a DOTA (1,4,7,10-tetraazocyclododecane-N,N',N″,N'″-tetraacetic acid) derivative [(68)Ga-SCN-Benzyl(Bn)-DOTA-capsaicin] was studied for the diagnosis of breast cancers, such as MCF-7 and SK-BR-3. The standard compound, (69)Ga-SCN-Bn-DOTA-capsaicin, was also prepared and characterized by spectroscopic analysis. The binding affinity of (68)Ga-SCN-Bn-DOTA-capsaicin was evaluated by using breast cancer cell lines (MCF-7, SK-BR-3) and colon cancer cell (CT-26); the biodistribution was carried out by using MCF-7-bearing nude mice, after which the positron emission tomography (PET) images were obtained at different time intervals (15-120 minutes)...
June 2017: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28591728/generation-and-evaluation-of-antibody-agents-for-molecular-imaging-of-cd44v6-expressing-cancers
#8
Anna-Karin Haylock, Johan Nilvebrant, Anja Mortensen, Irina Velikyan, Marika Nestor, Ronny Falk
AIM: The aim of this study was to generate and characterize scFv antibodies directed to human CD44v6, as well as to radiolabel and evaluate top candidates in vitro and in vivo for their potential use in CD44v6-targeted molecular imaging in cancer patients. MATERIALS AND METHODS: Phage display selections were used to isolate CD44v6-specific scFvs. A chain shuffling strategy was employed for affinity maturation based on a set of CD44v6-specific first-generation clones...
May 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28570736/preclinical-pet-study-of-intravitreal-injections
#9
Anxo Fernández-Ferreiro, Andrea Luaces-Rodríguez, Pablo Aguiar, Juan Pardo-Montero, Miguel González-Barcia, Lara García-Varela, Michel Herranz, Jesús Silva-Rodríguez, María Gil-Martínez, María A Bermúdez, Alba Vieites-Prado, José Blanco-Méndez, María Jesús Lamas, Francisco Gómez-Ulla, Álvaro Ruibal, Francisco Javier Otero-Espinar, Francisco González
Purpose: This work aimed at describing the time course of vitreous clearance through the use of positron emission tomography (PET) as a noninvasive tool for pharmacokinetic studies of intravitreal injection. Methods: The pharmacokinetic profile of intravitreal injections of molecules labeled with 18Fluorine (18F) was evaluated in adult Sprague Dawley rats by using a dedicated small-animal PET/computed tomography scanner. Different conditions were studied: three molecules radiolabeled with 18F (18F-FDG, 18F-NaF, and 18F-Choline), three volumes of intravitreal injections (7, 4, and 2 μL), and absence or presence of eye inflammation (uveitis)...
June 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28566692/pilot-study-of-64-cu-i-for-pet-imaging-of-melanoma
#10
Lei Jiang, Yingfeng Tu, Xiang Hu, Ande Bao, Hao Chen, Xiaowei Ma, Tim Doyle, Hongcheng Shi, Zhen Cheng
At present, (64)Cu(II) labeled tracers including (64)CuCl2 have been widely applied in the research of molecular imaging and therapy. Human copper transporter 1 (hCTR1) is the major high affinity copper influx transporter in mammalian cells, and specially responsible for the transportation of Cu(I) not Cu(II). Thus, we investigated the feasible application of (64)Cu(I) for PET imaging. (64)Cu(II) was reduced to (64)Cu(I) with the existence of sodium L-ascorbate, DL-Dithiothreitol or cysteine. Cell uptake and efflux assay was investigated using B16F10 and A375 cell lines, respectively...
May 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28562337/il13ra2-targeted-alpha-particle-therapy-against-glioblastomas
#11
Anirudh Sattiraju, Kiran Kumar Solingapuram Sai, Ang Xuan, Darpan N Pandya, Frankis G Almaguel, Thaddeus J Wadas, Denise M Herpai, Waldemar Debinski, Akiva Mintz
Glioblastoma (GBM) is the most aggressive primary malignant brain cancer that invariably results in a dismal prognosis. Chemotherapy and radiotherapy have not been completely effective as standard treatment options for patients due to recurrent disease. We and others have therefore developed molecular strategies to specifically target interleukin 13 receptor alpha 2 (IL13RA2), a GBM restricted receptor expressed abundantly on over 75% of GBM patients. In this work, we evaluated the potential of Pep-1L, a novel IL13RA2 targeted peptide, as a platform to deliver targeted lethal therapies to GBM...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28516169/hybrid-pixel-waveform-hpwf-enabled-cdte-detectors-for-small-animal-gamma-ray-imaging-applications
#12
A Groll, K Kim, H Bhatia, J C Zhang, J H Wang, Z M Shen, L Cai, J Dutta, Q Li, L J Meng
This paper presents the design and preliminary evaluation of small-pixel CdTe gamma ray detectors equipped with a hybrid pixel-waveform (HPWF) readout system for gamma ray imaging applications with additional discussion on CZT due to its similarity. The HPWF readout system utilizes a pixelated anode readout circuitry which is designed to only provide the pixel address. This readout circuitry works in coincidence with a high-speed digitizer to sample the cathode waveform which provides the energy, timing, and depth-of-interaction (DOI) information...
January 2017: IEEE transactions on radiation and plasma medical sciences
https://www.readbyqxmd.com/read/28468949/identification-of-a-novel-the-itg%C3%AE-v%C3%AE-6-binding-peptide-using-protein-separation-and-phage-display
#13
Uwe Haberkorn, Annette Altmann, Max Sauter, Saskia Roesch, Walter Mier, Rolf Warta, Juergen Debus, Gerhard Dyckhoff, Christel Herold-Mende
PURPOSE: Targeted therapies are regarded as promising approaches to increase 5-year survival rate of head and neck squamous cell carcinoma (HNSCC) patients. EXPERIMENTAL DESIGN: For the selection of carcinoma-specific peptides membrane proteome of HNO97 tumor cells fractionated by the ProteomeLab™ PF2D system and corresponding HNO97 cells were deployed for an alternating biopanning using a sunflower trypsin inhibitor1-based phage display (SFTI8Ph) library. Stability, binding properties and affinity of novel candidates were assessed in vitro using radio-HPLC, binding experiments and surface plasmon resonance assay (SPR), respectively...
May 3, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28412013/investigation-of-the-imaging-characteristics-of-the-albira-ii-small-animal-pet-system-for-18-f-68-ga-and-64-cu
#14
Ali Asgar Attarwala, Yvonne Wanjiku Karanja, Deni Hardiansyah, Chiara Romanó, Mareike Roscher, Björn Wängler, Gerhard Glatting
AIM: In this study the performance characteristics of the Albira II PET sub-system and the response of the system for the following radionuclides (18)F, (68)Ga and (64)Cu was analyzed. MATERIALS AND METHODS: The Albira II tri-modal system (Bruker BioSpin MRI GmbH, Ettlingen, Germany) is a pre-clinical device for PET, SPECT and CT. The PET sub-system uses single continuous crystal detectors of lutetium yttrium orthosilicate (LYSO). The detector assembly consists of three rings of 8 detector modules...
April 12, 2017: Zeitschrift Für Medizinische Physik
https://www.readbyqxmd.com/read/28382139/in-vivo-imaging-of-experimental-melanoma-tumors-using-the-novel-radiotracer-68-ga-nodaga-procainamide-pca
#15
István Kertész, András Vida, Gábor Nagy, Miklós Emri, Antal Farkas, Adrienn Kis, János Angyal, Noémi Dénes, Judit P Szabó, Tünde Kovács, Péter Bai, György Trencsényi
PURPOSE: The most aggressive form of skin cancer is the malignant melanoma. Because of its high metastatic potential the early detection of primary melanoma tumors and metastases using non-invasive PET imaging determines the outcome of the disease. Previous studies have already shown that benzamide derivatives, such as procainamide (PCA) specifically bind to melanin pigment. The aim of this study was to synthesize and investigate the melanin specificity of the novel (68)Ga-labeled NODAGA-PCA molecule in vitro and in vivo using PET techniques...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28361250/influence-of-co-57-and-ct-transmission-measurements-on-the-quantification-accuracy-and-partial-volume-effect-of-a-small-animal-pet-scanner
#16
Julia G Mannheim, Andreas M Schmid, Bernd J Pichler
PURPOSE: Non-invasive in vivo positron emission tomography (PET) provides high detection sensitivity in the nano- to picomolar range and in addition to other advantages, the possibility to absolutely quantify the acquired data. The present study focuses on the comparison of transmission data acquired with an X-ray computed tomography (CT) scanner or a Co-57 source for the Inveon small animal PET scanner (Siemens Healthcare, Knoxville, TN, USA), as well as determines their influences on the quantification accuracy and partial volume effect (PVE)...
March 30, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28301817/simple-and-rapid-radiosynthesis-of-n-18-f-labeled-glutamic-acid-as-a-hepatocellular-carcinoma-pet-tracer
#17
Aixia Sun, Shaoyu Liu, Xiaolan Tang, Dahong Nie, Ganghua Tang, Zhanwen Zhang, Fuhua Wen, Xiaoyan Wang
INTRODUCTION: We have reported that N-(2-(18)F-fluoropropionyl)-L-glutamate ((18)F-FPGLU) showed good tumor-to-background contrast and (18)F-FPGLU was prepared via complex multi-step reaction sequence; here, it is synthesized by a facile two-step reaction sequence. The objectives of this study are to synthesize (18)F-FPGLU via a two-step reaction sequence and to evaluate the value of (18)F-FPGLU in nude mice bearing human hepatocellular carcinoma SMCC-7721 (HCC SMCC-7721). METHODS: (18)F-FPGLU was synthetized from the precursor (2S)-dimethyl 2-(2-bromopropanamido)pentanedioate via the two-step on-column hydrolysis using a modified commercial FDG synthesizer...
June 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28219717/effects-of-tetrahydrocannabinol-on-glucose-uptake-in-the-rat-brain
#18
I Miederer, K Uebbing, J Röhrich, S Maus, N Bausbacher, K Krauter, V Weyer-Elberich, B Lutz, M Schreckenberger, R Urban
Δ(9)-Tetrahydrocannabinol (THC) is the psychoactive component of the plant Cannabis sativa and acts as a partial agonist at cannabinoid type 1 and type 2 receptors in the brain. The goal of this study was to assess the effect of THC on the cerebral glucose uptake in the rat brain. 21 male Sprague Dawley rats (12-13 w) were examined and received five different doses of THC ranging from 0.01 to 1 mg/kg. For data acquisition a Focus 120 small animal PET scanner was used and 24.1-28.0 MBq of [(18)F]-fluoro-2-deoxy-d-glucose were injected...
February 20, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28146242/positron-emission-tomography-for-the-development-and-characterization-of-corneal-permanence-of-ophthalmic-pharmaceutical-formulations
#19
Anxo Fernández-Ferreiro, Jesús Silva-Rodríguez, Francisco Javier Otero-Espinar, Miguel González-Barcia, María Jesús Lamas, Alvaro Ruibal, Andrea Luaces-Rodriguez, Alba Vieites-Prado, Tomas Sobrino, Michel Herranz, Lara García-Varela, José Blanco-Mendez, María Gil-Martínez, María Pardo, Alexis Moscoso, Santiago Medín-Aguerre, Juan Pardo-Montero, Pablo Aguiar
Purpose: This work is aimed at describing the utility of positron emission tomography/computed tomography (PET/CT) as a noninvasive tool for pharmacokinetic studies of biopermanence of topical ocular formulations. Methods: The corneal biopermanence of a topical ophthalmic formulation containing gellan gum and kappa carragenan (0.82% wt/vol) labeled with 18Fluorine (18F) radiotracers (18F-FDG and 18F-NaF) was evaluated by using a dedicated small-animal PET/CT, and compared with the biopermanence of an aqueous solution labeled with the same compounds...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28097210/preclinical-positron-emission-tomography-scanner-based-on-a-monolithic-annulus-of-scintillator-initial-design-study
#20
Alexander V Stolin, Peter F Martone, Gangadhar Jaliparthi, Raymond R Raylman
Positron emission tomography (PET) scanners designed for imaging of small animals have transformed translational research by reducing the necessity to invasively monitor physiology and disease progression. Virtually all of these scanners are based on the use of pixelated detector modules arranged in rings. This design, while generally successful, has some limitations. Specifically, use of discrete detector modules to construct PET scanners reduces detection sensitivity and can introduce artifacts in reconstructed images, requiring the use of correction methods...
January 2017: Journal of Medical Imaging
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