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https://www.readbyqxmd.com/read/29593508/gabaergic-control-of-nigrostriatal-and-mesolimbic-dopamine-in-the-rat-brain
#1
Susanne Nikolaus, Hans-Jörg Wittsack, Markus Beu, Christina Antke, Maria A De Souza Silva, Frijthof Wickrath, Anja Müller-Lutz, Joseph P Huston, Gerald Antoch, Hans-Wilhelm Müller, Hubertus Hautzel
Purpose: The present study assessed the effects of the GABAA receptor (R) agonist muscimol (MUS), and the GABAA R antagonist bicuculline (BIC) on neocortical and subcortical radioligand binding to dopamine D2/3 Rs in relation to motor and exploratory behaviors in the rat. Methods: D2/3 R binding was measured with small animal SPECT in baseline and after challenge with either 1 mg/kg MUS or 1 mg/kg BIC, using [123 I]IBZM as radioligand. Motor/exploratory behaviors were assessed for 30 min in an open field prior to radioligand administration...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29487319/magnetic-resonance-imaging-of-atherosclerotic-plaque-at-clinically-relevant-field-strengths-1t-by-targeting-the-integrin-%C3%AE-4%C3%AE-1
#2
Darren G Woodside, Eric A Tanifum, Ketan B Ghaghada, Ronald J Biediger, Amy R Caivano, Zbigniew A Starosolski, Sayadeth Khounlo, Saakshi Bhayana, Shahrzad Abbasi, John W Craft, David S Maxwell, Chandreshkumar Patel, Igor V Stupin, Deenadayalan Bakthavatsalam, Robert V Market, James T Willerson, Richard A F Dixon, Peter Vanderslice, Ananth V Annapragada
Inflammation drives the degradation of atherosclerotic plaque, yet there are no non-invasive techniques available for imaging overall inflammation in atherosclerotic plaques, especially in the coronary arteries. To address this, we have developed a clinically relevant system to image overall inflammatory cell burden in plaque. Here, we describe a targeted contrast agent (THI0567-targeted liposomal-Gd) that is suitable for magnetic resonance (MR) imaging and binds with high affinity and selectivity to the integrin α4β1(very late antigen-4, VLA-4), a key integrin involved in recruiting inflammatory cells to atherosclerotic plaques...
February 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29392701/bioluminescent-in-vivo-imaging-of-orthotopic-glioblastoma-xenografts-in-mice
#3
Joshua D Frenster, Dimitris G Placantonakis
Orthotopic rodent xenografts are an essential tool for studying glioblastoma in vivo. Xenograft growth as a function of time can only be monitored by noninvasive imaging. This chapter describes in detail how to assess xenograft size and growth using bioluminescent imaging with IVIS (in vivo imaging system). This form of imaging (a) can be performed without the help of a trained technician, (b) is a very quick procedure, allowing simultaneous imaging of up to five animals at a total experimental duration of 15 min, and (c) is cheaper than the alternatives (small animal MRI or CT)...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29364211/pet-and-mri-guided-irradiation-of-a-glioblastoma-rat-model-using-a-micro-irradiator
#4
Julie Bolcaen, Benedicte Descamps, Tom Boterberg, Christian Vanhove, Ingeborg Goethals
For decades, small animal radiation research was mostly performed using fairly crude experimental setups applying simple single-beam techniques without the ability to target a specific or well-delineated tumor volume. The delivery of radiation was achieved using fixed radiation sources or linear accelerators producing megavoltage (MV) X-rays. These devices are unable to achieve sub-millimeter precision required for small animals. Furthermore, the high doses delivered to healthy surrounding tissue hamper response assessment...
December 28, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29282070/9-4-t-small-animal-mri-using-clinical-components-for-direct-translational-studies
#5
Jörg Felder, A Avdo Celik, Chang-Hoon Choi, Stefan Schwan, N Jon Shah
BACKGROUND: Magnetic resonance is a major preclinical and clinical imaging modality ideally suited for longitudinal studies, e.g. in pharmacological developments. The lack of a proven platform that maintains an identical imaging protocol between preclinical and clinical platforms is solved with the construction of an animal scanner based on clinical hard- and software. METHODS: A small animal magnet and gradient system were connected to a clinical MR system. Several hardware components were either modified or built in-house to achieve compatibility...
December 28, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29089533/proton-minibeam-radiation-therapy-spares-normal-rat-brain-long-term-clinical-radiological-and-histopathological-analysis
#6
Yolanda Prezado, Gregory Jouvion, David Hardy, Annalisa Patriarca, Catherine Nauraye, Judith Bergs, Wilfredo González, Consuelo Guardiola, Marjorie Juchaux, Dalila Labiod, Remi Dendale, Laurène Jourdain, Catherine Sebrie, Frederic Pouzoulet
Proton minibeam radiation therapy (pMBRT) is a novel strategy for minimizing normal tissue damage resulting from radiotherapy treatments. This strategy partners the inherent advantages of protons for radiotherapy with the gain in normal tissue preservation observed upon irradiation with narrow, spatially fractionated beams. In this study, whole brains (excluding the olfactory bulb) of Fischer 344 rats (n = 16) were irradiated at the Orsay Proton Therapy Center. Half of the animals received standard proton irradiation, while the other half were irradiated with pMBRT at the same average dose (25 Gy in one fraction)...
October 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28976180/magnetic-particle-imaging-for-real-time-perfusion-imaging-in-acute-stroke
#7
Peter Ludewig, Nadine Gdaniec, Jan Sedlacik, Nils D Forkert, Patryk Szwargulski, Matthias Graeser, Gerhard Adam, Michael G Kaul, Kannan M Krishnan, R Matthew Ferguson, Amit P Khandhar, Piotr Walczak, Jens Fiehler, Götz Thomalla, Christian Gerloff, Tobias Knopp, Tim Magnus
The fast and accurate assessment of cerebral perfusion is fundamental for the diagnosis and successful treatment of stroke patients. Magnetic particle imaging (MPI) is a new radiation-free tomographic imaging method with a superior temporal resolution, compared to other conventional imaging methods. In addition, MPI scanners can be built as prehospital mobile devices, which require less complex infrastructure than computed tomography (CT) and magnetic resonance imaging (MRI). With these advantages, MPI could accelerate the stroke diagnosis and treatment, thereby improving outcomes...
October 24, 2017: ACS Nano
https://www.readbyqxmd.com/read/28835220/cardiovascular-magnetic-resonance-feature-tracking-in-small-animals-a-preliminary-study-on-reproducibility-and-sample-size-calculation
#8
Tomas Lapinskas, Jana Grune, Seyedeh Mahsa Zamani, Sarah Jeuthe, Daniel Messroghli, Rolf Gebker, Heike Meyborg, Ulrich Kintscher, Remigijus Zaliunas, Burkert Pieske, Philipp Stawowy, Sebastian Kelle
BACKGROUND: Cardiovascular magnetic resonance feature tracking (CMR-FT) is a novel tissue tracking technique developed for noninvasive assessment of myocardial motion and deformation. This preliminary study aimed to evaluate the observer's reproducibility of CMR-FT in a small animal (mouse) model and define sample size calculation for future trials. METHODS: Six C57BL/6 J mice were selected from the ongoing experimental mouse model onsite and underwent CMR with a 3 Tesla small animal MRI scanner...
August 23, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/28796368/regularly-incremented-phase-encoding-mr-fingerprinting-ripe-mrf-for-enhanced-motion-artifact-suppression-in-preclinical-cartesian-mr-fingerprinting
#9
Christian E Anderson, Charlie Y Wang, Yuning Gu, Rebecca Darrah, Mark A Griswold, Xin Yu, Chris A Flask
PURPOSE: The regularly incremented phase encoding-magnetic resonance fingerprinting (RIPE-MRF) method is introduced to limit the sensitivity of preclinical MRF assessments to pulsatile and respiratory motion artifacts. METHODS: As compared to previously reported standard Cartesian-MRF methods (SC-MRF), the proposed RIPE-MRF method uses a modified Cartesian trajectory that varies the acquired phase-encoding line within each dynamic MRF dataset. Phantoms and mice were scanned without gating or triggering on a 7T preclinical MRI scanner using the RIPE-MRF and SC-MRF methods...
April 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28651245/high-resolution-hyperpolarized-in-vivo-metabolic-13-c-spectroscopy-at-low-magnetic-field-48-7mt-following-murine-tail-vein-injection
#10
Aaron M Coffey, Matthew A Feldman, Roman V Shchepin, Danila A Barskiy, Milton L Truong, Wellington Pham, Eduard Y Chekmenev
High-resolution (13)C NMR spectroscopy of hyperpolarized succinate-1-(13)C-2,3-d2 is reported in vitro and in vivo using a clinical-scale, biplanar (80cm-gap) 48.7mT permanent magnet with a high homogeneity magnetic field. Non-localized (13)C NMR spectra were recorded at 0.52MHz resonance frequency over the torso of a tumor-bearing mouse every 2s. Hyperpolarized (13)C NMR signals with linewidths of ∼3Hz (corresponding to ∼6ppm) were recorded in vitro (2mL in a syringe) and in vivo (over a mouse torso). Comparison of the full width at half maximum (FWHM) for (13)C NMR spectra acquired at 48...
August 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28264905/perforin-expression-by-cd8-t-cells-is-sufficient-to-cause-fatal-brain-edema-during-experimental-cerebral-malaria
#11
Matthew A Huggins, Holly L Johnson, Fang Jin, Aurelie N Songo, Lisa M Hanson, Stephanie J LaFrance, Noah S Butler, John T Harty, Aaron J Johnson
Human cerebral malaria (HCM) is a serious complication of Plasmodium falciparum infection. The most severe outcomes for patients include coma, permanent neurological deficits, and death. Recently, a large-scale magnetic resonance imaging (MRI) study in humans identified brain swelling as the most prominent predictor of fatal HCM. Therefore, in this study, we sought to define the mechanism controlling brain edema through the use of the murine experimental cerebral malaria (ECM) model. Specifically, we investigated the ability of CD8 T cells to initiate brain edema during ECM...
May 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28018953/high-resolution-three-dimensional-quantitative-map-of-the-macromolecular-proton-fraction-distribution-in-the-normal-rat-brain
#12
Anna V Naumova, Andrey E Akulov, Marina Yu Khodanovich, Vasily L Yarnykh
The presented dataset provides a normative high-resolution three-dimensional (3D) macromolecular proton fraction (MPF) map of the healthy rat brain in vivo and source images used for its reconstruction. The images were acquired using the protocol described elsewhere (Naumova, et al. High-resolution three-dimensional macromolecular proton fraction mapping for quantitative neuroanatomical imaging of the rodent brain in ultra-high magnetic fields. Neuroimage (2016) doi: 10.1016/j.neuroimage.2016.09.036). The map was reconstructed from three source images with different contrast weightings (proton density, T1, and magnetization transfer) using the single-point algorithm with a synthetic reference image...
February 2017: Data in Brief
https://www.readbyqxmd.com/read/27807535/rat-heterotopic-heart-transplantation-model-to-investigate-unloading-induced-myocardial-remodeling
#13
REVIEW
Xuebin Fu, Adrian Segiser, Thierry P Carrel, Hendrik T Tevaearai Stahel, Henriette Most
Unloading of the failing left ventricle in order to achieve myocardial reverse remodeling and improvement of contractile function has been developed as a strategy with the increasing frequency of implantation of left ventricular assist devices in clinical practice. But, reverse remodeling remains an elusive target, with high variability and exact mechanisms still largely unclear. The small animal model of heterotopic heart transplantation (hHTX) in rodents has been widely implemented to study the effects of complete and partial unloading on cardiac failing and non-failing tissue to better understand the structural and molecular changes that underlie myocardial recovery...
2016: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27677296/diffusion-tensor-imaging-analysis-of-the-brain-in-the-canine-model-of-krabbe-disease
#14
Allison Bradbury, David Peterson, Charles Vite, Steven Chen, N Matthew Ellinwood, James Provenzale
PURPOSE: The goal of this study was to compare the diffusion tensor imaging (DTI) metrics from an end-stage canine Krabbe brain evaluated by MR imaging ex vivo to those of a normal dog brain. We hypothesized that the white matter of the canine Krabbe brain would show decreased fractional anisotropy (FA) values and increased apparent diffusion coefficient (ADC) and radial diffusivity (RD) values. METHODS: An 11-week-old Krabbe dog was euthanized after disease progression...
December 2016: Neuroradiology Journal
https://www.readbyqxmd.com/read/27663453/respiratory-self-gated-3d-ute-for-lung-imaging-in-small-animal-mri
#15
Marta Tibiletti, Andrea Bianchi, Åsmund Kjørstad, Stefan Wundrak, Detlef Stiller, Volker Rasche
PURPOSE: To investigate retrospective respiratory gating of three-dimensional ultrashort echo time (3D UTE) lung acquisition in free-breathing rats using k-space center self gating signal (DC-SG) and 3D image-based SG (3D-Img-SG). METHODS: Seven rats were investigated with a quasi-random 3D UTE protocol. Low-resolution time-resolved sliding-window images were reconstructed with a 3D golden-angle radial sparse parallel (GRASP) reconstruction to extract a 3D-Img-SG signal, whereas DC-SG was extracted from the center of k-space...
September 23, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27592719/silica-coated-nonstoichiometric-nano-zn-ferrites-for-magnetic-resonance-imaging-and-hyperthermia-treatment
#16
Fabian H L Starsich, Georgios A Sotiriou, Moritz C Wurnig, Christian Eberhardt, Ann M Hirt, Andreas Boss, Sotiris E Pratsinis
Large-scale and reproducible synthesis of nanomaterials is highly sought out for successful translation into clinics. Flame aerosol technology with its proven capacity to manufacture high purity materials (e.g., light guides) up to kg h-1 is explored here for the preparation of highly magnetic, nonstoichiometric Zn-ferrite (Zn0.4 Fe2.6 O4 ) nanoparticles coated in situ with a nanothin SiO2 layer. The focus is on their suitability as magnetic multifunctional theranostic agents analyzing their T2 contrast enhancing capability for magnetic resonance imaging (MRI) and their magnetic hyperthermia performance...
October 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27467829/high-resolution-diffusion-tensor-spinal-cord-mri-measures-as-biomarkers-of-disability-progression-in-a-rodent-model-of-progressive-multiple-sclerosis
#17
Francesca Gilli, Xi Chen, Andrew R Pachner, Barjor Gimi
Disease in the spinal cord is a major component of disability in multiple sclerosis, yet current techniques of imaging spinal cord injury are insensitive and nonspecific. This study seeks to remove this major impediment to research in multiple sclerosis and other spinal cord diseases by identifying reliable biomarkers of disability progression using diffusion tensor imaging (DTI), a magnetic resonance imaging technique, to evaluate the spinal cord in a model of multiple sclerosis, i.e. the Theiler's Murine Encephalitis Virus-Induced Demyelinating Disease (TMEV-IDD)...
2016: PloS One
https://www.readbyqxmd.com/read/27457491/evaluation-of-occurring-complications-after-flow-diverter-treatment-of-elastase-induced-aneurysm-in-rabbits-using-micro-ct-and-mri-at-9-4-t
#18
COMPARATIVE STUDY
Andreas Simgen, Désirée Ley, Christian Roth, Giorgio Franco Maria Cattaneo, Ruben Mühl-Benninghaus, Andreas Müller, Heiko Körner, Yoo-Jin Kim, Bruno Scheller, Wolfgang Reith, Umut Yilmaz
INTRODUCTION: Flow diverters are increasingly being used to treat intracranial aneurysms. This study evaluates occurring complications of flow-diverting devices in the treatment of experimental aneurysms, involving the use of micro-CT and small animal MRI at 9.4 T, in correlation to angiographic and histological findings. METHODS: We previously published two preclinical studies, in which we assessed two different flow diverters in the treatment of elastase-induced aneurysms...
October 2016: Neuroradiology
https://www.readbyqxmd.com/read/27196585/tumour-specific-delivery-of-sirna-coupled-superparamagnetic-iron-oxide-nanoparticles-targeted-against-plk1-stops-progression-of-pancreatic-cancer
#19
Ujjwal M Mahajan, Steffen Teller, Matthias Sendler, Raghavendra Palankar, Cindy van den Brandt, Theresa Schwaiger, Jens-Peter Kühn, Silvia Ribback, Gunnar Glöckl, Matthias Evert, Werner Weitschies, Norbert Hosten, Frank Dombrowski, Mihaela Delcea, Frank-Ulrich Weiss, Markus M Lerch, Julia Mayerle
OBJECTIVE: Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies and is projected to be the second leading cause of cancer-related death by 2030. Despite extensive knowledge and insights into biological properties and genetic aberrations of PDAC, therapeutic options remain temporary and ineffective. One plausible explanation for the futile response to therapy is an insufficient and non-specific delivery of anticancer drugs to the tumour site. DESIGN: Superparamagnetic iron oxide nanoparticles (SPIONs) coupled with siRNA directed against the cell cycle-specific serine-threonine-kinase, Polo-like kinase-1 (siPLK1-StAv-SPIONs), could serve a dual purpose for delivery of siPLK1 to the tumour and for non-invasive assessment of efficiency of delivery in vivo by imaging the tumour response...
November 2016: Gut
https://www.readbyqxmd.com/read/27081173/simultaneous-multiparametric-pet-mri-with-silicon-photomultiplier-pet-and-ultra-high-field-mri-for-small-animal-imaging
#20
Guen Bae Ko, Hyun Suk Yoon, Kyeong Yun Kim, Min Sun Lee, Bo Yeun Yang, Jae Min Jeong, Dong Soo Lee, In Chan Song, Seok-Ki Kim, Daehong Kim, Jae Sung Lee
UNLABELLED: Visualization of biologic processes at molecular and cellular levels has revolutionized the understanding and treatment of human diseases. However, no single biomedical imaging modality provides complete information, resulting in the emergence of multimodal approaches. Combining state-of-the-art PET and MRI technologies without loss of system performance and overall image quality can provide opportunities for new scientific and clinical innovations. Here, we present a multiparametric PET/MR imager based on a small-animal dedicated, high-performance, silicon photomultiplier (SiPM) PET system and a 7-T MR scanner...
August 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
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