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"small animal MRI"

Matthew A Huggins, Holly L Johnson, Fang Jin, Aurelie N Songo, Lisa M Hanson, Stephanie J LaFrance, Noah S Butler, John T Harty, Aaron J Johnson
Human cerebral malaria (HCM) is a serious complication of Plasmodium falciparum infection. The most severe outcomes for patients include coma, permanent neurological deficits, and death. Recently, a large-scale magnetic resonance imaging (MRI) study in humans identified brain swelling as the most prominent predictor of fatal HCM. Therefore, in this study, we sought to define the mechanism controlling brain edema through the use of the murine experimental cerebral malaria (ECM) model. Specifically, we investigated the ability of CD8 T cells to initiate brain edema during ECM...
May 2017: Infection and Immunity
Anna V Naumova, Andrey E Akulov, Marina Yu Khodanovich, Vasily L Yarnykh
The presented dataset provides a normative high-resolution three-dimensional (3D) macromolecular proton fraction (MPF) map of the healthy rat brain in vivo and source images used for its reconstruction. The images were acquired using the protocol described elsewhere (Naumova, et al. High-resolution three-dimensional macromolecular proton fraction mapping for quantitative neuroanatomical imaging of the rodent brain in ultra-high magnetic fields. Neuroimage (2016) doi: 10.1016/j.neuroimage.2016.09.036). The map was reconstructed from three source images with different contrast weightings (proton density, T1, and magnetization transfer) using the single-point algorithm with a synthetic reference image...
February 2017: Data in Brief
Xuebin Fu, Adrian Segiser, Thierry P Carrel, Hendrik T Tevaearai Stahel, Henriette Most
Unloading of the failing left ventricle in order to achieve myocardial reverse remodeling and improvement of contractile function has been developed as a strategy with the increasing frequency of implantation of left ventricular assist devices in clinical practice. But, reverse remodeling remains an elusive target, with high variability and exact mechanisms still largely unclear. The small animal model of heterotopic heart transplantation (hHTX) in rodents has been widely implemented to study the effects of complete and partial unloading on cardiac failing and non-failing tissue to better understand the structural and molecular changes that underlie myocardial recovery...
2016: Frontiers in Cardiovascular Medicine
Allison Bradbury, David Peterson, Charles Vite, Steven Chen, N Matthew Ellinwood, James Provenzale
PURPOSE: The goal of this study was to compare the diffusion tensor imaging (DTI) metrics from an end-stage canine Krabbe brain evaluated by MR imaging ex vivo to those of a normal dog brain. We hypothesized that the white matter of the canine Krabbe brain would show decreased fractional anisotropy (FA) values and increased apparent diffusion coefficient (ADC) and radial diffusivity (RD) values. METHODS: An 11-week-old Krabbe dog was euthanized after disease progression...
December 2016: Neuroradiology Journal
Marta Tibiletti, Andrea Bianchi, Åsmund Kjørstad, Stefan Wundrak, Detlef Stiller, Volker Rasche
PURPOSE: To investigate retrospective respiratory gating of three-dimensional ultrashort echo time (3D UTE) lung acquisition in free-breathing rats using k-space center self gating signal (DC-SG) and 3D image-based SG (3D-Img-SG). METHODS: Seven rats were investigated with a quasi-random 3D UTE protocol. Low-resolution time-resolved sliding-window images were reconstructed with a 3D golden-angle radial sparse parallel (GRASP) reconstruction to extract a 3D-Img-SG signal, whereas DC-SG was extracted from the center of k-space...
September 23, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Fabian H L Starsich, Georgios A Sotiriou, Moritz C Wurnig, Christian Eberhardt, Ann M Hirt, Andreas Boss, Sotiris E Pratsinis
Large-scale and reproducible synthesis of nanomaterials is highly sought out for successful translation into clinics. Flame aerosol technology with its proven capacity to manufacture high purity materials (e.g., light guides) up to kg h(-1) is explored here for the preparation of highly magnetic, nonstoichiometric Zn-ferrite (Zn0.4 Fe2.6 O4 ) nanoparticles coated in situ with a nanothin SiO2 layer. The focus is on their suitability as magnetic multifunctional theranostic agents analyzing their T2 contrast enhancing capability for magnetic resonance imaging (MRI) and their magnetic hyperthermia performance...
September 5, 2016: Advanced Healthcare Materials
Francesca Gilli, Xi Chen, Andrew R Pachner, Barjor Gimi
Disease in the spinal cord is a major component of disability in multiple sclerosis, yet current techniques of imaging spinal cord injury are insensitive and nonspecific. This study seeks to remove this major impediment to research in multiple sclerosis and other spinal cord diseases by identifying reliable biomarkers of disability progression using diffusion tensor imaging (DTI), a magnetic resonance imaging technique, to evaluate the spinal cord in a model of multiple sclerosis, i.e. the Theiler's Murine Encephalitis Virus-Induced Demyelinating Disease (TMEV-IDD)...
2016: PloS One
Andreas Simgen, Désirée Ley, Christian Roth, Giorgio Franco Maria Cattaneo, Ruben Mühl-Benninghaus, Andreas Müller, Heiko Körner, Yoo-Jin Kim, Bruno Scheller, Wolfgang Reith, Umut Yilmaz
INTRODUCTION: Flow diverters are increasingly being used to treat intracranial aneurysms. This study evaluates occurring complications of flow-diverting devices in the treatment of experimental aneurysms, involving the use of micro-CT and small animal MRI at 9.4 T, in correlation to angiographic and histological findings. METHODS: We previously published two preclinical studies, in which we assessed two different flow diverters in the treatment of elastase-induced aneurysms...
October 2016: Neuroradiology
Ujjwal M Mahajan, Steffen Teller, Matthias Sendler, Raghavendra Palankar, Cindy van den Brandt, Theresa Schwaiger, Jens-Peter Kühn, Silvia Ribback, Gunnar Glöckl, Matthias Evert, Werner Weitschies, Norbert Hosten, Frank Dombrowski, Mihaela Delcea, Frank-Ulrich Weiss, Markus M Lerch, Julia Mayerle
OBJECTIVE: Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies and is projected to be the second leading cause of cancer-related death by 2030. Despite extensive knowledge and insights into biological properties and genetic aberrations of PDAC, therapeutic options remain temporary and ineffective. One plausible explanation for the futile response to therapy is an insufficient and non-specific delivery of anticancer drugs to the tumour site. DESIGN: Superparamagnetic iron oxide nanoparticles (SPIONs) coupled with siRNA directed against the cell cycle-specific serine-threonine-kinase, Polo-like kinase-1 (siPLK1-StAv-SPIONs), could serve a dual purpose for delivery of siPLK1 to the tumour and for non-invasive assessment of efficiency of delivery in vivo by imaging the tumour response...
November 2016: Gut
Guen Bae Ko, Hyun Suk Yoon, Kyeong Yun Kim, Min Sun Lee, Bo Yeun Yang, Jae Min Jeong, Dong Soo Lee, In Chan Song, Seok-Ki Kim, Daehong Kim, Jae Sung Lee
UNLABELLED: Visualization of biologic processes at molecular and cellular levels has revolutionized the understanding and treatment of human diseases. However, no single biomedical imaging modality provides complete information, resulting in the emergence of multimodal approaches. Combining state-of-the-art PET and MRI technologies without loss of system performance and overall image quality can provide opportunities for new scientific and clinical innovations. Here, we present a multiparametric PET/MR imager based on a small-animal dedicated, high-performance, silicon photomultiplier (SiPM) PET system and a 7-T MR scanner...
August 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Caroline Sophie Laura Jung, Markus Heine, Barbara Freund, Rudolph Reimer, Eva Jolanthe Koziolek, Michael Gerhard Kaul, Fabian Kording, Udo Schumacher, Horst Weller, Peter Nielsen, Gerhard Adam, Jörg Heeren, Harald Ittrich
OBJECTIVES: The aim of this study was to determine metabolic activity of brown adipose tissue (BAT) with in vivo magnetic resonance imaging (MRI) after intravenous (IV) and intraperitoneal (IP) injection of radioactively labeled superparamagnetic iron oxide nanoparticles (SPIOs) embedded into a lipoprotein layer. MATERIALS AND METHODS: Fe-labeled SPIOs were either polymer-coated or embedded into the lipid core of triglyceride-rich lipoproteins (TRL-Fe-SPIOs). First biodistribution and blood half time analysis in thermoneutral mice after IP injection of either TRL-Fe-SPIOs or polymer-coated Fe-SPIOs (n = 3) were performed...
March 2016: Investigative Radiology
Johanna Sápi, Levente Kovács, Dániel András Drexler, Pál Kocsis, Dávid Gajári, Zoltán Sápi
BACKGROUND: Bevacizumab is an exogenous inhibitor which inhibits the biological activity of human VEGF. Several studies have investigated the effectiveness of bevacizumab therapy according to different cancer types but these days there is an intense debate on its utility. We have investigated different methods to find the best tumor volume estimation since it creates the possibility for precise and effective drug administration with a much lower dose than in the protocol. MATERIALS AND METHODS: We have examined C38 mouse colon adenocarcinoma and HT-29 human colorectal adenocarcinoma...
2015: PloS One
Yunkou Wu, Shanrong Zhang, Todd C Soesbe, Jing Yu, Elena Vinogradov, Robert E Lenkinski, A Dean Sherry
PURPOSE: This study explored the feasibility of using a pH responsive paramagnetic chemical exchange saturation transfer (paraCEST) agent to image the pH gradient in kidneys of healthy mice. METHODS: CEST signals were acquired on an Agilent 9.4 Tesla small animal MRI system using a steady-state gradient echo pulse sequence after a bolus injection of agent. The magnetic field inhomogeneity across each kidney was corrected using the WASSR method and pH maps were calculated by measuring the frequency of water exchange signal arising from the agent...
June 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Lynn J Frohwein, Verena Hoerr, Cornelius Faber, Klaus P Schäfers
PURPOSE: The fusion of positron emission tomography (PET) and magnetic resonance imaging (MRI) data can be a challenging task in whole-body PET-MRI. The quality of the registration between these two modalities in large field-of-views (FOV) is often degraded by geometric distortions of the MRI data. The distortions at the edges of large FOVs mainly originate from MRI gradient nonlinearities. This work describes a method to measure and correct for these kind of geometric distortions in small animal MRI scanners to improve the registration accuracy of PET and MRI data...
July 2015: Medical Physics
Arvid Hope, Linda B Stuhr, Tina Pavlin, Alvhild Alette Bjørkum, Marit Grønning
AIMS: The main objectives of the present study was to establish an animal model of decompression sickness (DCS) after heliox saturation diving, and to use this model to evaluate possible morphological changes in the CNS induced by DCS using structural MRI. METHODS: Two groups of rats were pressurized with heliox to 5 bar (pO2 = 50 kPa). The saturation time was three hours; decompression rate was 1 bar/10 seconds or 1 bar/20 seconds. A 7.0 Tesla small animal MRI scanner was used for detection of possible morphological changes in the brain and spinal cord, two hours and one week after the dive, compared to one week prior to the dive...
January 2015: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
Sabrina Doblas, Gilberto S Almeida, François-Xavier Blé, Philippe Garteiser, Benjamin A Hoff, Dominick J O McIntyre, Lydia Wachsmuth, Thomas L Chenevert, Cornelius Faber, John R Griffiths, Andreas H Jacobs, David M Morris, James P B O'Connor, Simon P Robinson, Bernard E Van Beers, John C Waterton
PURPOSE: To evaluate between-site agreement of apparent diffusion coefficient (ADC) measurements in preclinical magnetic resonance imaging (MRI) systems. MATERIALS AND METHODS: A miniaturized thermally stable ice-water phantom was devised. ADC (mean and interquartile range) was measured over several days, on 4.7T, 7T, and 9.4T Bruker, Agilent, and Magnex small-animal MRI systems using a common protocol across seven sites. Day-to-day repeatability was expressed as percent variation of mean ADC between acquisitions...
December 2015: Journal of Magnetic Resonance Imaging: JMRI
H Kim, C-T Chen, N Eclov, A Ronzhin, P Murat, E Ramberg, S Los, Alice M Wyrwicz, Limin Li, C-M Kao
We are developing a time-of-flight Positron Emission Tomography (PET) detector by using silicon photo-multipliers (SiPM) on a strip-line and high speed waveform sampling data acquisition. In this design, multiple SiPMs are connected on a single strip-line and signal waveforms on the strip-line are sampled at two ends of the strip to reduce readout channels while fully exploiting the fast time response of SiPMs. In addition to the deposited energy and time information, the position of the hit SiPM along the strip-line is determined by the arrival time difference of the waveform...
June 1, 2015: Nuclear Instruments & Methods in Physics Research. Section A, Accelerators, Spectrometers, Detectors and Associated Equipment
Kyoung-Nam Kim, Jeung-Hoon Seo, Sang-Doc Han, Phil Heo, Geun Ho Im, Jung Hee Lee
The purpose of this study was to develop a new double-layer coupled (DLC) surface radiofrequency (RF) coil using a combination of single-layer planar (SLP) and single-layer circular (SLC) coils, for enhancement of magnetic flux (B1 ) sensitivity and RF penetration in 7 T rat-body magnetic resonance imaging (MRI). The proposed DLC surface coil was fabricated according to an electromagnetic (EM) simulation and validated based on the B1 distribution and bench measurements. The DLC coil performance was quantitatively evaluated based on the signal-to-noise ratio (S/N) and coil-response signal intensity curves in phantom and in vivo rat-body images...
September 2015: Scanning
Philipp Rene Bovenkamp, Tobias Brix, Florian Lindemann, Richard Holtmeier, Desiree Abdurrachim, Michael T Kuhlmann, Gustav J Strijkers, Jörg Stypmann, Klaus H Hinrichs, Verena Hoerr
OBJECTIVES: In this study, we established and validated a time-resolved three-dimensional phase-contrast magnetic resonance imaging method (4D PC MRI) on a 9.4 T small-animal MRI system. Herein we present the feasibility of 4D PC MRI in terms of qualitative and quantitative flow pattern analysis in mice with transverse aortic constriction (TAC). MATERIALS AND METHODS: 4D PC FLASH images of a flow phantom and mouse heart were acquired at 9.4 T using a four-point phase-encoding scheme...
August 2015: Magma
Oleh Dzyubachyk, Artem Khmelinskii, Esben Plenge, Peter Kok, Thomas J A Snoeks, Dirk H J Poot, Clemens W G M Löwik, Charl P Botha, Wiro J Niessen, Louise van der Weerd, Erik Meijering, Boudewijn P F Lelieveldt
In small animal imaging studies, when the locations of the micro-structures of interest are unknown a priori, there is a simultaneous need for full-body coverage and high resolution. In MRI, additional requirements to image contrast and acquisition time will often make it impossible to acquire such images directly. Recently, a resolution enhancing post-processing technique called super-resolution reconstruction (SRR) has been demonstrated to improve visualization and localization of micro-structures in small animal MRI by combining multiple low-resolution acquisitions...
2014: PloS One
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