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https://www.readbyqxmd.com/read/28234794/african-american-patient-preferences-for-glaucoma-education
#1
Betsy Sleath, Scott Davis, Robyn Sayner, Delesha M Carpenter, Terence Johnson, Susan J Blalock, Alan L Robin
PURPOSE: The objectives of the study were to examine (a) the types of questions that African American patients have about glaucoma for their providers and (b) how patients' sociodemographic characteristics are associated with where and from whom they would like to learn about glaucoma and glaucoma medications. METHODS: Forty-nine adult African American patients with glaucoma were recruited at a private ophthalmology clinic where they completed a questionnaire for this cross-sectional study...
February 24, 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28234669/a-longitudinal-investigation-of-the-home-literacy-environment-and-shared-book-reading-in-young-children-with-hearing-loss
#2
Jean L DesJardin, Carren J Stika, Laurie S Eisenberg, Karen C Johnson, Dianne M Hammes Ganguly, Shirley C Henning, Bethany G Colson
OBJECTIVES: The principle goal of this longitudinal study was to examine parent perceptions of home literacy environment (e.g., frequency of book reading, ease of book reading with child) and observed behaviors during shared book reading (SBR) interactions between parents and their children with hearing loss (HL) as compared with parents and their children with normal hearing (NH) across 3 time points (12, 24, and 36 months old). Relationships were also explored among home literacy environment factors and SBR behaviors and later language outcomes, across all three time points for parents of children with and without HL...
February 23, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28234636/a-three-arm-randomized-clinical-trial-comparing-continuous-femoral-plus-single-injection-sciatic-peripheral-nerve-blocks-versus-periarticular-injection-with-ropivacaine-or-liposomal-bupivacaine-for-patients-undergoing-total-knee-arthroplasty
#3
Adam W Amundson, Rebecca L Johnson, Matthew P Abdel, Carlos B Mantilla, Jason K Panchamia, Michael J Taunton, Michael E Kralovec, James R Hebl, Darrell R Schroeder, Mark W Pagnano, Sandra L Kopp
BACKGROUND: Multimodal analgesia is standard practice for total knee arthroplasty; however, the role of regional techniques in improved perioperative outcomes remains unknown. The authors hypothesized that peripheral nerve blockade would result in lower pain scores and opioid consumption than two competing periarticular injection solutions. METHODS: This three-arm, nonblinded trial randomized 165 adults undergoing unilateral primary total knee arthroplasty to receive (1) femoral catheter plus sciatic nerve blocks, (2) ropivacaine-based periarticular injection, or (3) liposomal bupivacaine-based periarticular injection...
February 24, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28234350/annual-community-patterns-are-driven-by-seasonal-switching-between-closely-related-marine-bacteria
#4
Christopher S Ward, Cheuk-Man Yung, Katherine M Davis, Sara K Blinebry, Tiffany C Williams, Zackary I Johnson, Dana E Hunt
Marine microbes exhibit seasonal cycles in community composition, yet the key drivers of these patterns and microbial population fidelity to specific environmental conditions remain to be determined. To begin addressing these questions, we characterized microbial dynamics weekly for 3 years at a temperate, coastal site with dramatic environmental seasonality. This high-resolution time series reveals that changes in microbial community composition are not continuous; over the duration of the time series, the community instead resolves into distinct summer and winter profiles with rapid spring and fall transitions between these states...
February 24, 2017: ISME Journal
https://www.readbyqxmd.com/read/28234199/reliability-and-validity-of-the-sexual-experiences-survey-short-forms-victimization-and-perpetration
#5
Shannon M Johnson, Megan J Murphy, Christine A Gidycz
The Sexual Experiences Survey (SES), the most widely used measure of unwanted sexual experiences, was recently updated (Koss et al., 2007). The purpose of this study was to provide psychometric data on the updated Sexual Experiences Survey-Short Form Perpetration (SES-SFP) and the Sexual Experiences Survey-Short Form Victimization (SES-SFV). Men (n = 136) and women (n = 433) were randomly assigned to in-person or Internet formats of administration for 3 measurement points. Women completed victimization surveys and trauma measures...
February 1, 2017: Violence and Victims
https://www.readbyqxmd.com/read/28234008/-strebloside-induced-cytotoxicity-in-ovarian-cancer-cells-is-mediated-through-cardiac-glycoside-signaling-networks
#6
Wei-Lun Chen, Yulin Ren, Jinhong Ren, Christian Erxleben, Michael E Johnson, Saverio Gentile, A Douglas Kinghorn, Steven M Swanson, Joanna E Burdette
(+)-Strebloside, a cardiac glycoside isolated from the stem bark of Streblus asper collected in Vietnam, has shown some potential for further investigation as an antineoplastic agent. A mechanistic study using an in vitro assay and molecular docking analysis indicated that (+)-strebloside binds and inhibits Na(+)/K(+)-ATPase in a similar manner to digitoxin. Inhibition of growth of different high-grade serous ovarian cancer cells including OVCAR3, OVSAHO, Kuramochi, OVCAR4, OVCAR5, and OVCAR8 resulted from treatment with (+)-strebloside...
February 24, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28233908/self-management-interventions-in-pediatric-epilepsy-what-is-the-level-of-evidence
#7
REVIEW
Janelle L Wagner, Avani C Modi, Erica K Johnson, Ross Shegog, Cam Escoffery, Yvan Bamps, Joan K Austin, Rebecca J Schultz, Sarah MapelLentz, Gigi Smith
OBJECTIVE: To respond to recommendations put forth by the Institute of Medicine to improve self-management resources for youth with epilepsy by conducting a systematic review of the self-management literature in pediatric epilepsy. METHODS: Inclusion criteria: youth birth to 18 years with a seizure disorder or an epilepsy diagnosis and/or their caregivers, published 1985-2014 in English, and conducted in countries with a very high human development index. Abstract and keywords had to explicitly refer to "self-care" (pre-1996) and/or self-management (post-1996)...
February 24, 2017: Epilepsia
https://www.readbyqxmd.com/read/28233802/targeting-neoantigens-to-augment-antitumour-immunity
#8
REVIEW
Mark Yarchoan, Burles A Johnson, Eric R Lutz, Daniel A Laheru, Elizabeth M Jaffee
The past decade of cancer research has been marked by a growing appreciation of the role of immunity in cancer. Mutations in the tumour genome can cause tumours to express mutant proteins that are tumour specific and not expressed on normal cells (neoantigens). These neoantigens are an attractive immune target because their selective expression on tumours may minimize immune tolerance as well as the risk of autoimmunity. In this Review we discuss the emerging evidence that neoantigens are recognized by the immune system and can be targeted to increase antitumour immunity...
February 24, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28233663/autism-as-an-adaptive-common-variant-pathway-for-human-brain-development
#9
REVIEW
Mark H Johnson
While research on focal perinatal lesions has provided evidence for recovery of function, much less is known about processes of brain adaptation resulting from mild but widespread disturbances to neural processing over the early years (such as alterations in synaptic efficiency). Rather than being viewed as a direct behavioral consequence of life-long neural dysfunction, I propose that autism is best viewed as the end result of engaging adaptive processes during a sensitive period. From this perspective, autism is not appropriately described as a disorder of neurodevelopment, but rather as an adaptive common variant pathway of human functional brain development...
February 9, 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/28233655/induction-and-maintenance-immunosuppression-treatment-of%C3%A2-proliferative-lupus-nephritis-a-network-meta-analysis-of%C3%A2-randomized-trials
#10
Suetonia C Palmer, David J Tunnicliffe, Davinder Singh-Grewal, Dimitris Mavridis, Marcello Tonelli, David W Johnson, Jonathan C Craig, Allison Tong, Giovanni F M Strippoli
BACKGROUND: Intravenous (IV) cyclophosphamide has been first-line treatment for inducing disease remission in lupus nephritis. The comparative efficacy and toxicity of newer agents such as mycophenolate mofetil (MMF) and calcineurin inhibitors are uncertain. STUDY DESIGN: Network meta-analysis. SETTING & POPULATION: Patients with proliferative lupus nephritis. SELECTION CRITERIA FOR STUDIES: Randomized trials of immunosuppression to induce or maintain disease remission...
February 20, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28233364/prospective-comparison-of-tumor-staging-using-computed-tomography-versus-magnetic-resonance-imaging-findings-in-dogs-with-nasal-neoplasia-a-pilot-study
#11
Cassie N Lux, William T N Culp, Lynelle R Johnson, Michael Kent, Philipp Mayhew, Lise A Daniaux, Alaina Carr, Sarah Puchalski
Identification of nasal neoplasia extension and tumor staging in dogs is most commonly performed using computed tomography (CT), however magnetic resonance imaging (MRI) is routinely used in human medicine. A prospective pilot study enrolling six dogs with nasal neoplasia was performed with CT and MRI studies acquired under the same anesthetic episode. Interobserver comparison and comparison between the two imaging modalities with regard to bidimensional measurements of the nasal tumors, tumor staging using historical schemes, and assignment of an ordinal scale of tumor margin clarity at the tumor-soft tissue interface were performed...
February 24, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28233328/goosefish-lophius-americanus-fecundity-and-spawning-frequency-with-implications-for-population-reproductive-potential
#12
R S McBride, A K Johnson, E K Lindsay, H J Walsh, R A Richards
To improve knowledge of goosefish Lophius americanus' reproductive biology, females were collected during 2009-2012 from the Mid-Atlantic Bight shelf region of the U.S. east coast. Batch fecundity increased with total length (LT ), from 229 100 to 2 243 300 mature oocytes per female (LT range: 55·5-112 cm; n = 54). This estimate of fecundity at LT is lower than one derived from a sample collected during 1982-1985. Examination of whole oocyte diameters in different months indicated that L. americanus is a serial spawner, releasing more than one egg veil per spawning season, as suspected or observed for other Lophius species...
February 23, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28233274/the-safety-of-appropriate-use-of-over-the-counter-proton-pump-inhibitors-an-evidence-based-review-and-delphi-consensus
#13
REVIEW
David A Johnson, Philip O Katz, David Armstrong, Henry Cohen, Brendan C Delaney, Colin W Howden, Peter Katelaris, Radu I Tutuian, Donald O Castell
The availability of over-the-counter (OTC) proton pump inhibitors (PPIs) for the short-term (2 weeks) management of frequent heartburn (≥2 days/week) has increased markedly, yet evidence-based recommendations have not been developed. A panel of nine international experts in gastroesophageal reflux disease developed consensus statements regarding the risks and benefits of OTC PPIs using a modified Delphi process. Consensus (based on ≥80% approval) was reached through multiple rounds of remote voting and a final round of live voting...
February 23, 2017: Drugs
https://www.readbyqxmd.com/read/28233109/is-secukinumab-a-safe-alternative-treatment-for-ankylosing-spondylitis-with-guillain-barr%C3%A3-syndrome-after-anti-tnf-%C3%AE-treatment-case-report-and-literature-review
#14
REVIEW
Savvas Psarelis, Andreas P D Hajineocli, Eleni Hadjicosta, Hugh St A Elliott, Paul Johnson
In this report, we aim to add to the existing body of evidence regarding a link between anti- tumor necrosis factor alpha (anti-TNF-α) treatment and demyelination leading to neurological disorders, specifically Guillain Barré syndrome (GBS), and treatment with an interleukin-17A (IL17A) antagonist as a safe alternative for ankylosing spondylitis (AS). A literature review was carried out of current research concerning anti-TNF-α and induced GBS. Only papers published in English were reviewed and only peer-reviewed journals searched...
February 23, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28231513/increasing-ascorbate-levels-in-crops-to-enhance-human-nutrition-and-plant-abiotic-stress-tolerance
#15
REVIEW
Richard C Macknight, William A Laing, Sean M Bulley, Ronan C Broad, Alexander At Johnson, Roger P Hellens
Ascorbate (or vitamin C) is an essential human micronutrient predominantly obtained from plants. In addition to preventing scurvy, it is now known to have broader roles in human health, for example as a cofactor for enzymes involved in epigenetic programming and as regulator of cellular iron uptake. Furthermore, ascorbate is the major antioxidant in plants and underpins many environmentally induced abiotic stress responses. Biotechnological approaches to enhance the ascorbate content of crops therefore have potential to improve both human health and abiotic stress tolerance of crops...
February 20, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/28231133/soybean-enriched-snacks-based-on-african-rice
#16
Mauro Marengo, Hannah F Akoto, Miriam Zanoletti, Aristodemo Carpen, Simona Buratti, Simona Benedetti, Alberto Barbiroli, Paa-Nii T Johnson, Esther O Sakyi-Dawson, Firibu K Saalia, Francesco Bonomi, Maria Ambrogina Pagani, John Manful, Stefania Iametti
Snacks were produced by extruding blends of partially-defatted soybean flour with flours from milled or parboiled African-grown rice. The interplay between composition and processing in producing snacks with a satisfactory sensory profile was addressed by e-sensing, and by molecular and rheological approaches. Soybean proteins play a main role in defining the properties of the protein network in the products. At the same content in soybean flour, use of parboiled rice flour increases the snack's hardness. Electronic nose and electronic tongue discriminated samples containing a higher amount of soybean flour from those with a lower soybean flour content...
May 20, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28230447/effect-of-medicaid-policy-changes-on-medication-adherence-differences-by-baseline-adherence
#17
Krutika Amin, Joel F Farley, Matthew L Maciejewski, Marisa E Domino
BACKGROUND: In 2001, the North Carolina (NC) Medicaid program reduced the number of days prescription supply that enrollees could fill from 100 days to 34 days and increased copayments for brand-name medications. Previous work has shown that a change in these policies led to a decrease in medication adherence from 2.9 to 8.0 percentage points in specific populations with chronic conditions. Studies have also shown that days supply limits and copayment increases have heterogeneous effects based on enrollees' baseline characteristics, including baseline adherence...
March 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28230292/age-related-changes-in-pain-sensitivity-in-healthy-humans-a-systematic-review-with-meta-analysis
#18
REVIEW
H El Tumi, M I Johnson, P B F Dantas, M J Maynard, O A Tashani
: Literature suggests that pain perception diminishes in old age. The most recent review used search strategies conducted over a decade ago and concluded that study findings were equivocal. The aim of this systematic review, with meta-analysis, was to determine age-related changes in pain sensitivity in healthy pain-free adults, children and adolescents. A search of PubMed, Science Direct, and PsycINFO identified studies that compared pain sensitivity response to noxious stimuli at different time points in the lifespan of healthy individuals...
February 23, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28230263/recent-advances-in-%C3%AE-aminobutyric-acid-gaba-properties-in-pulses-an-overview
#19
REVIEW
Nooshin Nikmaram, B N Dar, Shahin Roohinejad, Mohamed Koubaa, Francisco J Barba, Greiner Ralf, Stuart K Johnson
Beans, peas, and lentils are all types of pulses that are extensively used as foods around the world due to their beneficial effects on human health including their low glycemic index, cholesterol lowering effects, ability to decrease the risk of heart diseases and their protective effects against some cancers. These health benefits are a result of their components such as bioactive proteins, dietary fibers, slowly digested starches, minerals and vitamins, and bioactive compounds. Among these bioactive compounds, γ-aminobutyric acid (GABA), a non-proteinogenic amino acid with numerous reported health benefits (e...
February 23, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28230154/compiler-aided-systematic-construction-of-large-scale-dna-strand-displacement-circuits-using-unpurified-components
#20
Anupama J Thubagere, Chris Thachuk, Joseph Berleant, Robert F Johnson, Diana A Ardelean, Kevin M Cherry, Lulu Qian
Biochemical circuits made of rationally designed DNA molecules are proofs of concept for embedding control within complex molecular environments. They hold promise for transforming the current technologies in chemistry, biology, medicine and material science by introducing programmable and responsive behaviour to diverse molecular systems. As the transformative power of a technology depends on its accessibility, two main challenges are an automated design process and simple experimental procedures. Here we demonstrate the use of circuit design software, combined with the use of unpurified strands and simplified experimental procedures, for creating a complex DNA strand displacement circuit that consists of 78 distinct species...
February 23, 2017: Nature Communications
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