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https://www.readbyqxmd.com/read/29129788/a-new-formulation-of-poly-maotib-nanoparticles-as-an-efficient-contrast-agent-for-in-vivo-x-ray-imaging
#1
Justine Wallyn, Nicolas Anton, Christophe Serra, Michel Bouquey, Mayeul Collot, Halina Anton, Jean-Luc Weickert, Nadia Messaddeq, Thierry F Vandamme
Polymeric nanoparticles (PNPs) are gaining increasing importance as nanocarriers or contrasting material for preclinical diagnosis by micro-CT scanner. Here, we investigated a straightforward approach to produce a biocompatible, radiopaque, and stable polymer-based nanoparticle contrast agent, which was evaluated on mice. To this end, we used a nanoprecipitation dropping technique to obtain PEGylated PNPs from a preformed iodinated homopolymer, poly(MAOTIB), synthesized by radical polymerization of 2-methacryloyloxyethyl(2,3,5-triiodobenzoate) monomer (MAOTIB)...
November 9, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29075922/mouse-models-of-neurodegenerative-disease-preclinical-imaging-and-neurovascular-component
#2
Sandra Albanese, Adelaide Greco, Luigi Auletta, Marcello Mancini
Neurodegenerative diseases represent great challenges for basic science and clinical medicine because of their prevalence, pathologies, lack of mechanism-based treatments, and impacts on individuals. Translational research might contribute to the study of neurodegenerative diseases. The mouse has become a key model for studying disease mechanisms that might recapitulate in part some aspects of the corresponding human diseases. Neurodegenerative disorders are very complicated and multifactorial. This has to be taken in account when testing drugs...
October 26, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29073049/production-of-diverse-pet-probes-with-limited-resources-24-18-f-labeled-compounds-prepared-with-a-single-radiosynthesizer
#3
Jeffrey Collins, Christopher M Waldmann, Christopher Drake, Roger Slavik, Noel S Ha, Maxim Sergeev, Mark Lazari, Bin Shen, Frederick T Chin, Melissa Moore, Saman Sadeghi, Michael E Phelps, Jennifer M Murphy, R Michael van Dam
New radiolabeled probes for positron-emission tomography (PET) are providing an ever-increasing ability to answer diverse research and clinical questions and to facilitate the discovery, development, and clinical use of drugs in patient care. Despite the high equipment and facility costs to produce PET probes, many radiopharmacies and radiochemistry laboratories use a dedicated radiosynthesizer to produce each probe, even if the equipment is idle much of the time, to avoid the challenges of reconfiguring the system fluidics to switch from one probe to another...
October 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29039474/evaluation-of-a-radiocobalt-labelled-affibody-molecule-for-imaging-of-human-epidermal-growth-factor-receptor-3-expression
#4
Maria Rosestedt, Ken G Andersson, Bogdan Mitran, Sara S Rinne, Vladimir Tolmachev, John Löfblom, Anna Orlova, Stefan Ståhl
The human epidermal growth factor receptor 3 (HER3) is involved in the development of cancer resistance towards tyrosine kinase-targeted therapies. Several HER3‑targeting therapeutics are currently under clinical evaluation. Non-invasive imaging of HER3 expression could improve patient management. Affibody molecules are small engineered scaffold proteins demonstrating superior properties as targeting probes for molecular imaging compared with monoclonal antibodies. Feasibility of in vivo HER3 imaging using affibody molecules has been previously demonstrated...
October 11, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28971332/standardization-of-small-animal-imaging-current-status-and-future-prospects
#5
REVIEW
Julia G Mannheim, Firat Kara, Janine Doorduin, Kerstin Fuchs, Gerald Reischl, Sayuan Liang, Marleen Verhoye, Felix Gremse, Laura Mezzanotte, Marc C Huisman
The benefit of small animal imaging is directly linked to the validity and reliability of the collected data. If the data (regardless of the modality used) are not reproducible and/or reliable, then the outcome of the data is rather questionable. Therefore, standardization of the use of small animal imaging equipment, as well as of animal handling in general, is of paramount importance. In a recent paper, guidance for efficient small animal imaging quality control was offered and discussed, among others, the use of phantoms in setting up a quality control program (Osborne et al...
October 2, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28862997/a-novel-optically-transparent-rf-shielding-for-fully-integrated-pet-mri-systems
#6
C Parl, A Kolb, A M Schmid, H F Wehrl, J A Disselhorst, P D Soubiran, D Stricker-Shaver, B J Pichler
Preclinical imaging benefits from simultaneous acquisition of high-resolution anatomical and molecular data. Additionally, PET/MRI systems can provide functional PET and functional MRI data. To optimize PET sensitivity, we propose a system design that fully integrates the MRI coil into the PET system. This allows positioning the scintillators near the object but requires an optimized design of the MRI coil and PET detector. It further requires a new approach in realizing the radiofrequency (RF) shielding. Thus, we propose the use of an optically transparent RF shielding material between the PET scintillator and the light sensor, suppressing the interference between both systems...
September 1, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28840171/estimation-of-subject-coregistration-errors-during-multimodal-preclinical-imaging-using-separate-instruments-origins-and-avoidance-of-artifacts
#7
Jean-Philippe Dillenseger, Christian Goetz, Amira Sayeh, Chris Healy, Isabelle Duluc, Jean-Noël Freund, André Constantinesco, Gaëlle Aubertin-Kirch, Philippe Choquet
We use high-resolution [Formula: see text] data in multiple experiments to estimate the sources of error during coregistration of images acquired on separate preclinical instruments. In combination with experiments with phantoms, we completed in vivo imaging on mice, aimed at identifying the possible sources of registration errors, caused either by transport of the animal, movement of the animal itself, or methods of coregistration. The same imaging cell was used as a holder for phantoms and animals. For all procedures, rigid coregistration was carried out using a common landmark coregistration system, placed inside the imaging cell...
July 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28757665/passive-microlesion-detection-and-mapping-for-treatment-of-hypertrophic-cardiomyopathy
#8
Yiying I Zhu, Douglas L Miller, Chunyan Dou, Oliver D Kripfgans
Intermittent high intensity ultrasound pulses with circulating contrast agent microbubbles can induce scattered microlesions of potential value for myocardial reduction therapy. This paper presents an in vitro setup imitating the treatment for monitoring development. A preclinical imaging system with a single element transducer, synchronization and receive-only imaging transducer array has been implemented on a research platform. Contrast agent microbubbles pumped in a dialysis tubing setup were exposed to high intensity focused ultrasound at 1...
2017: AIP Conference Proceedings
https://www.readbyqxmd.com/read/28748183/neodymium-140-dota-lm3-evaluation-of-an-in-vivo-generator-for-pet-with-a-non-internalizing-vector
#9
Gregory W Severin, Lotte K Kristensen, Carsten H Nielsen, Jesper Fonslet, Andreas I Jensen, Anders F Frellsen, K M Jensen, Dennis R Elema, Helmut Maecke, Andreas Kjær, Karl Johnston, Ulli Köster
(140)Nd (t1/2 = 3.4 days), owing to its short-lived positron emitting daughter (140)Pr (t1/2 = 3.4 min), has promise as an in vivo generator for positron emission tomography (PET). However, the electron capture decay of (140)Nd is chemically disruptive to macrocycle-based radiolabeling, meaning that an in vivo redistribution of the daughter (140)Pr is expected before positron emission. The purpose of this study was to determine how the delayed positron from the de-labeled (140)Pr affects preclinical imaging with (140)Nd...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28730928/feasibility-of-na-18-f-pet-ct-and-mri-for-noninvasive-in-vivo-quantification-of-knee-pathophysiological-bone-metabolism-in-a-canine-model-of-post-traumatic-osteoarthritis
#10
Maria I Menendez, Bianca Hettlich, Lai Wei, Michael V Knopp
PURPOSE: To assess and quantify by molecular imaging knee osseous metabolic changes serially in an in vivo canine model of posttraumatic osteoarthritis (PTOA) of the knee utilizing sodium fluoride (Na(18)F) positron emission tomography (PET)/computed tomography (CT) coregistered with magnetic resonance imaging (MRI). MATERIALS AND METHODS: Sodium fluoride PET imaging of 5 canines was performed prior to anterior cruciate ligament transection (ACLT) and 2 times post-ACLT (3 and 12 weeks)...
January 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28700135/a-hybrid-clustering-algorithm-for-multiple-source-resolving-in-bioluminescence-tomography
#11
Hongbo Guo, Jingjing Yu, Zhenhua Hu, Huangjian Yi, Yuqing Hou, Xiaowei He
Bioluminescence tomography is a preclinical imaging modality to locate and quantify internal bioluminescent sources from surface measurements, which experienced rapid growth in the last ten years. However, multiple-source resolving remains a challenging issue in BLT. In this paper, it is treated as an unsupervised pattern recognition problem based on the reconstruction result, and a novel hybrid clustering algorithm combining the advantages of affinity propagation (AP) and K-means is developed to identify multiple sources automatically...
July 12, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28678028/three-dimensional-ultrasound-versus-computerized-tomography-in-fat-graft-volumetric-analysis
#12
Charles Philip Blackshear, Michael Anthony Rector, Natalie Narie Chung, Dre Michael Irizarry, John Stephen Flacco, Elizabeth Anne Brett, Arash Momeni, Gordon Kwanlyp Lee, Michael T Longaker, Derrick C Wan
Studies evaluating fat grafting in mice have frequently used micro-computed tomography (micro-CT) as an accurate radiographic tool to measure longitudinal volume retention without killing the animal. Over the past decade, however, microultrasonography has emerged as an equally powerful preclinical imaging tool. Given their respective strengths in 3-dimensional reconstruction, there is no study to our knowledge that directly compares micro-CT with microultrasound in volumetric analysis. In this study, we compared the performance of micro-CT with microultrasound in the evaluation of adipose tissue graft volume in a murine model...
July 3, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28643891/direct-comparison-of-high-temporal-resolution-cine-mri-with-doppler-ultrasound-for-assessment-of-diastolic-dysfunction-in-mice
#13
Thomas A Roberts, Anthony N Price, Laurence H Jackson, Valerie Taylor, Anna L David, Mark F Lythgoe, Daniel J Stuckey
Diastolic dysfunction is a sensitive early indicator of heart failure and can provide additional data to conventional measures of systolic function. Transmitral Doppler ultrasound, which measures the one-dimensional flow of blood through the mitral valve, is currently the preferred method for the measurement of diastolic function, but the measurement of the left ventricular volume changes using high-temporal-resolution cinematic magnetic resonance imaging (CINE MRI) is an alternative approach which is emerging as a potentially more robust and user-independent technique...
October 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28596724/recent-advances-in-translational-magnetic-resonance-imaging-in-animal-models-of-stress-and-depression
#14
REVIEW
Allison L McIntosh, Shane Gormley, Leonardo Tozzi, Thomas Frodl, Andrew Harkin
Magnetic resonance imaging (MRI) is a valuable translational tool that can be used to investigate alterations in brain structure and function in both patients and animal models of disease. Regional changes in brain structure, functional connectivity, and metabolite concentrations have been reported in depressed patients, giving insight into the networks and brain regions involved, however preclinical models are less well characterized. The development of more effective treatments depends upon animal models that best translate to the human condition and animal models may be exploited to assess the molecular and cellular alterations that accompany neuroimaging changes...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28513760/cell-therapy-in-the-treatment-of-bipolar-mania-in-an-animal-model-a-proof-of-concept-study
#15
Bruna M Ascoli, Rafael Colombo, Luiza P Géa, Paula B Terraciano, Sabrina B Pizzato, Fernanda S de Oliveira, Elizabeth Cirne-Lima, Flávio Kapczinski, Adriane R Rosa
INTRODUCTION: The rationale of mesenchymal stem cells (MSCs) as a novel therapeutic approach in certain neurodegenerative diseases is based on their ability to promote neurogenesis. Hippocampal atrophy has been related to bipolar disorder (BD) in preclinical, imaging and postmortem studies. Therefore, the development of new strategies to stimulate the neurogenesis process in BD is crucial. OBJECTIVES: To investigate the behavioral and neurochemical changes induced by transplantation of MSCs in a model of mania-like behavior induced by lisdexamfetamine dimesylate (LDX)...
July 2017: Trends in Psychiatry and Psychotherapy
https://www.readbyqxmd.com/read/28495212/quantification-of-mouse-renal-perfusion-using-arterial-spin-labeled-mri-at-1%C3%A2-t
#16
Quyen N Do, Ananth J Madhuranthakam, Peter Bendel, Robert E Lenkinski
RATIONALE AND OBJECTIVES: Quantitative measurement of renal perfusion in murine models provides important information on the organ physiology and disease states. The 1-T desktop magnetic resonance imaging has a small footprint and a self-contained fringe field. This resultant flexibility in siting makes the system ideal for preclinical imaging research. Our objective was to evaluate the capability of the 1-T desktop magnetic resonance imaging to measure mouse renal perfusion without the administration of exogenous contrast agents...
May 8, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28460313/bf2-azadipyrromethene-nir-emissive-fluorophores-with-research-and-clinical-potential
#17
Harrison C Daly, Gonzalo Sampedro, Corentin Bon, Dan Wu, Ghazi Ismail, Ronan A Cahill, Donal F O'Shea
The use of near-infrared fluorescence for in vivo research and intraoperative clinical imaging is rapidly expanding, with new applications being proposed and developed. While imaging hardware and software have significantly progressed in recent times, the molecular fluorescent agents remain a limiting factor. In this report, the design, synthesis, photophysical characterization and bio-medical imaging assessment of two new NIR-fluorophores based on the BF2-azadipyrromethene fluorophore class are described...
July 28, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28435447/a-unique-recombinant-fluoroprobe-targeting-activated-platelets-allows-in-vivo-detection-of-arterial-thrombosis-and-pulmonary-embolism-using-a-novel-three-dimensional-fluorescence-emission-computed-tomography-flect-technology
#18
Bock Lim, Yu Yao, Alex Lin-I Huang, May Lin Yap, Ulrike Flierl, Jathushan Palasubramaniam, Maria T K Zaldivia, Xiaowei Wang, Karlheinz Peter
Progress in pharmaceutical development is highly-dependent on preclinical in vivo animal studies. Small animal imaging is invaluable for the identification of new disease markers and the evaluation of drug efficacy. Here, we report for the first time the use of a three-dimensional fluorescence bioimager called FLuorescence Emission Computed Tomography (FLECT) for the detection of a novel recombinant fluoroprobe that is safe, easily prepared on a large scale and stably stored prior to scan. This novel fluoroprobe (Targ-Cy7) comprises a single-chain antibody-fragment (scFvTarg), which binds exclusively to activated-platelets, conjugated to a near-infrared (NIR) dye, Cy7, for detection...
2017: Theranostics
https://www.readbyqxmd.com/read/28413809/preclinical-imaging-of-iridocorneal-angle-and-fundus-using-a-modified-integrated-flexible-handheld-probe
#19
Xun Jie Jeesmond Hong, Vengalathunadakal K Shinoj, Vadakke Matham Murukeshan, Mani Baskaran, Tin Aung
A flexible handheld imaging probe consisting of a [Formula: see text] charge-coupled device camera, light-emitting diode light sources, and near-infrared laser source is designed and developed. The imaging probe is designed with specifications to capture the iridocorneal angle images and posterior segment images. Light propagation from the anterior chamber of the eye to the exterior is considered analytically using Snell's law. Imaging of the iridocorneal angle region and fundus is performed on ex vivo porcine samples and subsequently on small laboratory animals, such as the New Zealand white rabbit and nonhuman primate, in vivo...
April 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28410210/non-invasive-assessment-of-murine-pd-l1-levels-in-syngeneic-tumor-models-by-nuclear-imaging-with-nanobody-tracers
#20
Katrijn Broos, Marleen Keyaerts, Quentin Lecocq, Dries Renmans, Tham Nguyen, David Escors, Adrian Liston, Geert Raes, Karine Breckpot, Nick Devoogdt
Blockade of the inhibitory PD-1/PD-L1 immune checkpoint axis is a promising cancer treatment. Nonetheless, a significant number of patients and malignancies do not respond to this therapy. To develop a screen for response to PD-1/PD-L1 inhibition, it is critical to develop a non-invasive tool to accurately assess dynamic immune checkpoint expression. Here we evaluated non-invasive SPECT/CT imaging of PD-L1 expression, in murine tumor models with varying PD-L1 expression, using high affinity PD-L1-specific nanobodies (Nbs)...
June 27, 2017: Oncotarget
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