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https://www.readbyqxmd.com/read/28069034/health-related-quality-of-life-and-unmet-healthcare-needs-in-huntington-s-disease
#1
Marleen R van Walsem, Emilie I Howe, Gunvor A Ruud, Jan C Frich, Nada Andelic
BACKGROUND: Huntington's disease (HD) is a rare neurodegenerative disorder with a prevalence of 6 per 100.000. Despite increasing research activity on HD, evidence on healthcare utilization, patients' needs for healthcare services and Health-Related Quality of Life (HRQoL) is still sparse. The present study describes HRQoL in a Norwegian cohort of HD patients, and assesses associations between unmet healthcare and social support service needs and HRQoL. METHODS: In this cross-sectional population-based study, 84 patients with a clinical diagnosis of HD living in the South-East of Norway completed the HRQoL questionnaire EuroQol, EQ-5D-3L...
January 7, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28065755/extended-spectrum-antiprotozoal-bumped-kinase-inhibitors-a-review
#2
Wesley C Van Voorhis, J Stone Doggett, Marilyn Parsons, Matthew A Hulverson, Ryan Choi, Samuel Arnold, Michael W Riggs, Andrew Hemphill, Daniel K Howe, Robert H Mealey, Audrey O T Lau, Ethan A Merritt, Dustin J Maly, Erkang Fan, Kayode K Ojo
Many life-cycle processes in parasites are regulated by protein phosphorylation. Hence, disruption of essential protein kinase function has been explored for therapy of parasitic diseases. However, the difficulty of inhibiting parasite protein kinases to the exclusion of host orthologues poses a practical challenge. A possible path around this difficulty is the use of bumped kinase inhibitors for targeting calcium dependent protein kinases that contain atypically small gatekeeper residues and are crucial for pathogenic apicomplexan parasites' survival and proliferation...
January 5, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28054939/effects-of-resveratrol-on-cognitive-performance-mood-and-cerebrovascular-function-in-post-menopausal-women-a-14-week-randomised-placebo-controlled-intervention-trial
#3
Hamish M Evans, Peter R C Howe, Rachel H X Wong
We tested whether chronic supplementation with resveratrol (a phytoestrogen) could improve cerebrovascular function, cognition and mood in post-menopausal women. Eighty post-menopausal women aged 45-85 years were randomised to take trans-resveratrol or placebo for 14 weeks and the effects on cognitive performance, cerebral blood flow velocity and pulsatility index (a measure of arterial stiffness) in the middle cerebral artery (using transcranial Doppler ultrasound), and cerebrovascular responsiveness (CVR) to both cognitive testing and hypercapnia were assessed...
January 3, 2017: Nutrients
https://www.readbyqxmd.com/read/28054821/multimodal-emotion-processing-deficits-are-present-in-amyotrophic-lateral-sclerosis
#4
Sophie C Andrews, Mathew Staios, Jim Howe, Katrina Reardon, Fiona Fisher
OBJECTIVE: Emotion processing abilities might be reduced in amyotrophic lateral sclerosis (ALS). Previous studies of emotion processing in ALS have inconsistent results, and are limited by variations in task difficulty, modalities examined, and participants' cognitive status. The current study used a battery of emotion processing tasks at differing levels of difficulty and across different modalities (facial affect and voice prosody) to assess the extent of emotion processing deficits in nondemented ALS...
January 5, 2017: Neuropsychology
https://www.readbyqxmd.com/read/28032333/the-effect-of-%C3%AE-1-adrenergic-blockade-on-post-exercise-brachial-artery-flow-mediated-dilatation-at-sea-level-and-high-altitude
#5
Michael M Tymko, Joshua C Tremblay, Alex B Hansen, Connor A Howe, Chris K Willie, Mike Stembridge, Daniel J Green, Ryan L Hoiland, Prajan Subedi, James D Anholm, Philip N Ainslie
KEY POINTS: Our objective was to quantify endothelial function (via brachial artery flow-mediated dilatation) at sea level (344 m) and high altitude (3800 m) at rest and following both maximal exercise and 30 min of moderate-intensity cycling exercise with and without administration of an α1 -adrenergic blockade. Brachial endothelial function did not differ between sea level and high altitude at rest, nor following maximal exercise. At sea level, endothelial function decreased following 30 min of moderate-intensity exercise, and this decrease was abolished with α1 -adrenergic blockade...
November 7, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/28013420/two-year-impact-of-prevention-programs-on-adolescent-depression-an-integrative-data-analysis-approach
#6
C Hendricks Brown, Ahnalee Brincks, Shi Huang, Tatiana Perrino, Gracelyn Cruden, Hilda Pantin, George Howe, Jami F Young, William Beardslee, Samantha Montag, Irwin Sandler
This paper presents the first findings of an integrative data analysis of individual-level data from 19 adolescent depression prevention trials (n = 5210) involving nine distinct interventions across 2 years post-randomization. In separate papers, several interventions have been found to decrease the risk of depressive disorders or elevated depressive/internalizing symptoms among youth. One type of intervention specifically targets youth without a depressive disorder who are at risk due to elevated depressive symptoms and/or having a parent with a depressive disorder...
December 24, 2016: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/28004446/is-h3k4me3-instructive-for-transcription-activation
#7
Françoise S Howe, Harry Fischl, Struan C Murray, Jane Mellor
Tri-methylation of lysine 4 on histone H3 (H3K4me3) is a near-universal chromatin modification at the transcription start site of active genes in eukaryotes from yeast to man and its levels reflect the amount of transcription. Because of this association, H3K4me3 is often described as an 'activating' histone modification and assumed to have an instructive role in the transcription of genes, but the field is lacking a conserved mechanism to support this view. The overwhelming finding from genome-wide studies is that actually very little transcription changes upon removal of most H3K4me3 under steady-state or dynamically changing conditions, including at mammalian CpG island promoters...
January 2017: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://www.readbyqxmd.com/read/27994759/design-and-synthesis-of-p2-p4-macrocycles-containing-a-unique-spirocyclic-proline-a-new-class-of-hcv-ns3-4a-inhibitors
#8
Francisco Velázquez, Mariappan Chelliah, Martin Clasby, Zhuyan Guo, John Howe, Randy Miller, Santhosh Neelamkavil, Unmesh Shah, Aileen Soriano, Yan Xia, Srikanth Venkatraman, Samuel Chackalamannil, Ian W Davies
A new class of hepatitis C NS3/4A inhibitors was identified by introducing a novel spirocyclic proline-P2 surrogate onto the P2-P4 macrocyclic core of MK-5172 (grazoprevir). The potency profile of new analogues showed excellent pan-genotypic activity for most compounds. The potency evaluation included the most difficult genotype 3a (EC50 values ≤10 nM) and other key genotype 1b mutants. Molecular modeling was used to design new target compounds and rationalize our results. A synthetic approach based on the Julia-Kocienski olefination and macrolactamization to assemble the P2-P4 macrocyclic core containing the novel spirocyclic proline-P2 moiety is presented as well...
December 8, 2016: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27979478/risk-factors-for-superficial-surgical-site-infection-after-elective-rectal-cancer-resection-a-multivariate-analysis-of-8880-patients-from-the-american-college-of-surgeons-national-surgical-quality-improvement-program-database
#9
Elie Sutton, Hiromichi Miyagaki, Geoffrey Bellini, H M C Shantha Kumara, Xiaohong Yan, Brett Howe, Amanda Feigel, Richard L Whelan
BACKGROUND: Superficial surgical site infection (sSSI) is one of the most common complications after colorectal resection. The goal of this study was to determine the comorbidities and operative characteristics that place patients at risk for sSSI in patients who underwent rectal cancer resection. METHODS: The American College of Surgeons National Surgical Quality Improvement Program database was queried (via diagnosis and Current Procedural Terminology codes) for patients with rectal cancer who underwent elective resection between 2005 and 2012...
January 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27899176/ecosystem-uptake-and-transfer-of-sellafield-derived-radiocarbon-14-c-part-2-the-west-of-scotland
#10
Kieran M Tierney, Graham K P Muir, Gordon T Cook, Gillian MacKinnon, John A Howe, Johanna J Heymans, David J Hughes, Sheng Xu
Ecosystem uptake and transfer of Sellafield-derived radiocarbon ((14)C) were examined within the West of Scotland marine environment. The dissolved inorganic carbon component of seawater, enriched in (14)C, is transported to the West of Scotland where it is transferred through the marine food web. Benthic and pelagic biota with variable life-spans living in the North Channel and Clyde Sea show comparable (14)C activities. This suggests that mixing of (14)C within the Irish Sea results in a relatively constant northwards dispersal of activity...
November 26, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/27870065/photoacclimatory-and-photoprotective-responses-to-cold-versus-heat-stress-in-high-latitude-reef-corals
#11
Stefanie Pontasch, Paul L Fisher, Thomas Krueger, Sophie Dove, William Leggat, Ove Hoegh-Guldberg, Simon K Davy
Corals at the world's southernmost coral reef of Lord Howe Island (LHI) experience large temperature and light fluctuations and need to deal with periods of cold temperature (< 18 °C), but few studies have investigated how corals are able to cope with these conditions. Our study characterized the response of key photophysiological parameters, as well as photoacclimatory and photoprotective pigments (chlorophylls, xanthophylls and β-carotene), to short-term (5-day) cold stress (~ 15 °C; 7 °C below control) in three LHI coral species hosting distinct Symbiodinium ITS2 types, and compared the coral-symbiont response to that under elevated temperature (~ 29 °C; 7 °C above control)...
November 21, 2016: Journal of Phycology
https://www.readbyqxmd.com/read/27863789/comparative-analysis-of-radioactive-iodine-versus-thyroidectomy-for-definitive-treatment-of-graves-disease
#12
Vincent T Wu, Allison W Lorenzen, Anna C Beck, Vincent J Reid, Sonia L Sugg, James R Howe, Janet H Pollard, Geeta Lal, Ronald J Weigel
BACKGROUND: Management of Graves disease includes antithyroid drugs, (131)I therapy, or thyroidectomy. Our aim was to review our institutional experience with definitive treatments for Graves disease. METHODS: This was a retrospective review of patients undergoing (131)I therapy (n = 295) or thyroidectomy (n = 103) for Graves disease (2003-2015). Demographic, clinical, pathology, and outcome data were collected from institutional databases. RESULTS: (131)I therapy patients were older (39...
January 2017: Surgery
https://www.readbyqxmd.com/read/27855202/identification-of-the-core-set-of-carbon-associated-genes-in-a-bioenergy-grassland-soil
#13
Adina Howe, Fan Yang, Ryan J Williams, Folker Meyer, Kirsten S Hofmockel
Despite the central role of soil microbial communities in global carbon (C) cycling, little is known about soil microbial community structure and even less about their metabolic pathways. Efforts to characterize soil communities often focus on identifying differences in gene content across environmental gradients, but an alternative question is what genes are similar in soils. These genes may indicate critical species or potential functions that are required in all soils. Here we identified the "core" set of C cycling sequences widely present in multiple soil metagenomes from a fertilized prairie (FP)...
2016: PloS One
https://www.readbyqxmd.com/read/27853542/electrical-output-of-bryophyte-microbial-fuel-cell-systems-is-sufficient-to-power-a-radio-or-an-environmental-sensor
#14
Paolo Bombelli, Ross J Dennis, Fabienne Felder, Matt B Cooper, Durgaprasad Madras Rajaraman Iyer, Jessica Royles, Susan T L Harrison, Alison G Smith, C Jill Harrison, Christopher J Howe
Plant microbial fuel cells are a recently developed technology that exploits photosynthesis in vascular plants by harnessing solar energy and generating electrical power. In this study, the model moss species Physcomitrella patens, and other environmental samples of mosses, have been used to develop a non-vascular bryophyte microbial fuel cell (bryoMFC). A novel three-dimensional anodic matrix was successfully created and characterized and was further tested in a bryoMFC to determine the capacity of mosses to generate electrical power...
October 2016: Royal Society Open Science
https://www.readbyqxmd.com/read/27852011/a-new-chicken-genome-assembly-provides-insight-into-avian-genome-structure
#15
Wesley C Warren, LaDeana W Hillier, Chad Tomlinson, Patrick Minx, Milinn Kremitzki, Tina Graves, Chris Markovic, Nathan Bouk, Kim D Pruitt, Francoise Thibaud-Nissen, Valerie Schneider, Tamer A Mansour, C Titus Brown, Aleksey Zimin, Rachel Hawken, Mitch Abrahamsen, Alexis B Pyrkosz, Mireille Morisson, Valerie Fillon, Alain Vignal, William Chow, Kerstin Howe, Janet E Fulton, Marcia M Miller, Peter Lovell, Claudio V Mello, Morgan Wirthlin, Andrew S Mason, Richard Kuo, David W Burt, Jerry B Dodgson, Hans H Cheng
The importance of the Gallus gallus (chicken) as a model organism and agricultural animal merits a continuation of sequence assembly improvement efforts. We present a new version of the chicken genome assembly (Gallus_gallus-5.0; GCA_000002315.3), built from combined long single molecule sequencing technology, finished BACs, and improved physical maps. In overall assembled bases, we see a gain of 183 Mb, including 16.4 Mb in placed chromosomes with a corresponding gain in the percentage of intact repeat elements characterized...
January 5, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/27849036/enterovirus-71-infection-of-motor-neuron-like-nsc-34-cells-undergoes-a-non-lytic-exit-pathway
#16
Issac Horng Khit Too, Huimin Yeo, October Michael Sessions, Benedict Yan, Eshele Anak Libau, Josephine L C Howe, Ze Qin Lim, Shalini Suku-Maran, Wei-Yi Ong, Kaw Bing Chua, Boon Seng Wong, Vincent T K Chow, Sylvie Alonso
Enterovirus 71 (EV71) causing Hand, Foot and Mouth Disease, is regarded as the most important neurotropic virus worldwide. EV71 is believed to replicate in muscles and infect motor neurons to reach the central nervous system (CNS). To further investigate the mechanisms involved, we have employed the motor neuron cell line NSC-34. NSC-34 cells were permissive to EV71 and virus production yields were strain-dependent with differential efficacy at the entry, replication and egress steps. Furthermore, unlike all the other cell lines previously reported, EV71-infected NSC-34 cells neither displayed cytopathic effect nor underwent apoptosis...
November 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27798266/focally-perfused-succinate-potentiates-brain-metabolism-in-head-injury-patients
#17
Ibrahim Jalloh, Adel Helmy, Duncan J Howe, Richard J Shannon, Peter Grice, Andrew Mason, Clare N Gallagher, Matthew G Stovell, Susan van der Heide, Michael P Murphy, John D Pickard, David K Menon, T Adrian Carpenter, Peter J Hutchinson, Keri Lh Carpenter
Following traumatic brain injury, complex cerebral energy perturbations occur. Correlating with unfavourable outcome, high brain extracellular lactate/pyruvate ratio suggests hypoxic metabolism and/or mitochondrial dysfunction. We investigated whether focal administration of succinate, a tricarboxylic acid cycle intermediate interacting directly with the mitochondrial electron transport chain, could improve cerebral metabolism. Microdialysis perfused disodium 2,3-(13)C2 succinate (12 mmol/L) for 24 h into nine sedated traumatic brain injury patients' brains, with simultaneous microdialysate collection for ISCUS analysis of energy metabolism biomarkers (nine patients) and nuclear magnetic resonance of (13)C-labelled metabolites (six patients)...
October 17, 2016: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27770579/febrile-infection-related-epilepsy-syndrome-treated-with-anakinra
#18
Daniel L Kenney-Jung, Annamaria Vezzani, Robert J Kahoud, Reghann G LaFrance-Corey, Mai-Lan Ho, Theresa Wampler Muskardin, Elaine C Wirrell, Charles L Howe, Eric T Payne
Febrile infection-related epilepsy syndrome (FIRES) is a devastating epileptic encephalopathy with limited treatment options and an unclear etiology. Anakinra is a recombinant version of the human interleukin-1 receptor antagonist used to treat autoinflammatory disorders. This is the first report of anakinra for treatment of a child with super-refractory status epilepticus secondary to FIRES. Anakinra was well tolerated and effective. Cerebral spinal fluid analysis revealed elevated levels of proinflammatory cytokines before treatment that normalized on anakinra, suggesting a potential pathogenic role for neuroinflammation in FIRES...
December 2016: Annals of Neurology
https://www.readbyqxmd.com/read/27770561/short-duration-treatment-with-elbasvir-grazoprevir-and-sofosbuvir-for-hepatitis-c-a-randomized-trial
#19
Eric Lawitz, Fred Poordad, Julio A Gutierrez, Jennifer T Wells, Carmen E Landaverde, Barbara Evans, Anita Howe, Hsueh-Cheng Huang, Jerry Jing Li, Peggy Hwang, Frank J Dutko, Michael Robertson, Janice Wahl, Eliav Barr, Barbara Haber
: Direct-acting antiviral agents (DAAs) represent the standard of care for patients with hepatitis C virus (HCV) infection. Combining DAAs with different mechanisms may allow for shorter treatment durations that are effective across multiple genotypes. The aim of the C-SWIFT study was to identify the minimum effective treatment duration across multiple genotypes. C-SWIFT was an open-label, single-center trial in treatment-naïve patients with chronic HCV genotype (GT)1 or 3 infection...
October 22, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27768313/sesterterpenoids-isolated-from-the-sponge-phorbas-sp-activate-latent-hiv-1-provirus-expression
#20
Meng Wang, Ian Tietjen, Min Chen, David E Williams, Julie Daoust, Mark A Brockman, Raymond J Andersen
Eight new sesterterpenoids, alotaketals D (8) and E (9), ansellones D (10), E (11), F (12), and G (13), and anvilones A (14) and B (15), have been isolated from extracts of the marine sponge Phorbas sp. collected in Howe Sound British Columbia, and their structures have been elucidated by analysis of NMR and MS data. Ansellone F (12) contains a rare 1,2-3,4-bis-epoxydecalin substructure. Anvilones A (14) and B (15) have an unprecedented tetracylic anvilane terpenoid carbon skeleton. Using a cell culture model of latent HIV-1 infection, ansellone A (3), alotaketal D (8), and anvilone A (14) were found to induce HIV proviral gene expression similar to the control compound prostratin (1), while the known sesterterpenoid alotaketal C (2), isolated from the same extract, was more potent and gave a stronger response than prostratin (1)...
November 18, 2016: Journal of Organic Chemistry
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