keyword
MENU ▼
Read by QxMD icon Read
search

Howe C

keyword
https://www.readbyqxmd.com/read/29773902/nedd9-promotes-oncogenic-signaling-a-stem-mesenchymal-gene-signature-and-aggressive-ovarian-cancer-growth-in-mice
#1
Rashid Gabbasov, Fang Xiao, Caitlin G Howe, Laura E Bickel, Shane W O'Brien, Daniel Benrubi, Thuy-Vy Do, Yan Zhou, Emmanuelle Nicolas, Kathy Q Cai, Samuel Litwin, Sachiko Seo, Erica A Golemis, Denise C Connolly
Neural precursor cell expressed, developmentally downregulated 9 (NEDD9) supports oncogenic signaling in a number of solid and hematologic tumors. Little is known about the role of NEDD9 in ovarian carcinoma (OC), but available data suggest elevated mRNA and protein expression in advanced stage high-grade cancers. We used a transgenic MISIIR-TAg mouse OC model combined with genetic ablation of Nedd9 to investigate its action in the development and progression of OC. A Nedd9-/- genotype delayed tumor growth rate, reduced incidence of ascites, and reduced expression and activation of signaling proteins including SRC, STAT3, E-cadherin, and AURKA...
May 18, 2018: Oncogene
https://www.readbyqxmd.com/read/29758589/spindle-cell-rhabdomyosarcoma-of-bone-with-fus-tfcp2-fusion-confirmation-of-a-very-recently-described-rhabdomyosarcoma-subtype
#2
Nooshin K Dashti, Rebecca N Wehrs, Brittany C Thomas, Asha Nair, Jaime Davila, Jan C Buckner, Anthony P Martinez, William R Sukov, Kevin C Halling, Benjamin M Howe, Andrew L Folpe
AIMS: Rhabdomyosarcomas of bone are extremely rare, with fewer than 10 reported cases. A very rare subtype of spindle cell/sclerosing rhabdomyosarcoma harboring a FUS-TFCP2 fusion and involving both soft tissue and bone locations has very recently been reported. We report only the fourth case of this unusual, clinically aggressive rhabdomyosarcoma. MATERIAL AND RESULTS: A previously-well 72-year old male presented with a destructive lesion of the mandible. Morphological and immunohistochemical study of a needle biopsy and the subsequent resection showed a spindle cell rhabdomyosarcoma...
May 14, 2018: Histopathology
https://www.readbyqxmd.com/read/29753233/associations-of-y-chromosomal-haplogroups-with-cardiometabolic-risk-factors-and-subclinical-vascular-measures-in-males-during-childhood-and-adolescence
#3
Linda M O'Keeffe, Laura D Howe, Abigail Fraser, Alun D Hughes, Kaitlin H Wade, Emma L Anderson, Debbie A Lawlor, A Mesut Erzurumluoglu, George Davey-Smith, Santiago Rodriguez, Evie Stergiakouli
BACKGROUND AND AIMS: Males have greater cardiometabolic risk than females, though the reasons for this are poorly understood. The aim of this study was to examine the association between common Y chromosomal haplogroups and cardiometabolic risk during early life. METHODS: In a British birth cohort, we examined the association of Y chromosomal haplogroups with trajectories of cardiometabolic risk factors from birth to 18 years and with carotid-femoral pulse wave velocity, carotid intima media thickness and left ventricular mass index at age 18...
April 25, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29716614/lewy-body-like-alpha-synuclein-inclusions-trigger-reactive-microgliosis-prior-to-nigral-degeneration
#4
Megan F Duffy, Timothy J Collier, Joseph R Patterson, Christopher J Kemp, Kelvin C Luk, Malú G Tansey, Katrina L Paumier, Nicholas M Kanaan, Luke D Fischer, Nicole K Polinski, Olivia L Barth, Jacob W Howe, Nishant N Vaikath, Nour K Majbour, Omar M A El-Agnaf, Caryl E Sortwell
BACKGROUND: Converging evidence suggests a role for microglia-mediated neuroinflammation in Parkinson's disease (PD). Animal models of PD can serve as a platform to investigate the role of neuroinflammation in degeneration in PD. However, due to features of the previously available PD models, interpretations of the role of neuroinflammation as a contributor to or a consequence of neurodegeneration have remained elusive. In the present study, we investigated the temporal relationship of neuroinflammation in a model of synucleinopathy following intrastriatal injection of pre-formed alpha-synuclein fibrils (α-syn PFFS)...
May 1, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29694188/search-for-neutrinoless-double-%C3%AE-decay-in-76-ge-with-the-majorana-demonstrator
#5
C E Aalseth, N Abgrall, E Aguayo, S I Alvis, M Amman, I J Arnquist, F T Avignone, H O Back, A S Barabash, P S Barbeau, C J Barton, P J Barton, F E Bertrand, T Bode, B Bos, M Boswell, A W Bradley, R L Brodzinski, V Brudanin, M Busch, M Buuck, A S Caldwell, T S Caldwell, Y-D Chan, C D Christofferson, P-H Chu, J I Collar, D C Combs, R J Cooper, C Cuesta, J A Detwiler, P J Doe, J A Dunmore, Yu Efremenko, H Ejiri, S R Elliott, J E Fast, P Finnerty, F M Fraenkle, Z Fu, B K Fujikawa, E Fuller, A Galindo-Uribarri, V M Gehman, T Gilliss, G K Giovanetti, J Goett, M P Green, J Gruszko, I S Guinn, V E Guiseppe, A L Hallin, C R Haufe, L Hehn, R Henning, E W Hoppe, T W Hossbach, M A Howe, B R Jasinski, R A Johnson, K J Keeter, J D Kephart, M F Kidd, A Knecht, S I Konovalov, R T Kouzes, B D LaFerriere, J Leon, K T Lesko, L E Leviner, J C Loach, A M Lopez, P N Luke, J MacMullin, S MacMullin, M G Marino, R D Martin, R Massarczyk, A B McDonald, D-M Mei, S J Meijer, J H Merriman, S Mertens, H S Miley, M L Miller, J Myslik, J L Orrell, C O'Shaughnessy, G Othman, N R Overman, G Perumpilly, W Pettus, D G Phillips, A W P Poon, K Pushkin, D C Radford, J Rager, J H Reeves, A L Reine, K Rielage, R G H Robertson, M C Ronquest, N W Ruof, A G Schubert, B Shanks, M Shirchenko, K J Snavely, N Snyder, D Steele, A M Suriano, D Tedeschi, W Tornow, J E Trimble, R L Varner, S Vasilyev, K Vetter, K Vorren, B R White, J F Wilkerson, C Wiseman, W Xu, E Yakushev, H Yaver, A R Young, C-H Yu, V Yumatov, I Zhitnikov, B X Zhu, S Zimmermann
The Majorana Collaboration is operating an array of high purity Ge detectors to search for neutrinoless double-β decay in ^{76}Ge. The Majorana Demonstrator comprises 44.1 kg of Ge detectors (29.7 kg enriched in ^{76}Ge) split between two modules contained in a low background shield at the Sanford Underground Research Facility in Lead, South Dakota. Here we present results from data taken during construction, commissioning, and the start of full operations. We achieve unprecedented energy resolution of 2...
March 30, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29687498/young-people-s-experiences-of-managing-type-1-diabetes-at-university-a-national-study-of-uk-university-students
#6
J Kellett, M Sampson, F Swords, H R Murphy, A Clark, A Howe, C Price, V Datta, K S Myint
AIM: Little is known about the challenges of transitioning from school to university for young people with Type 1 diabetes. In a national survey, we investigated the impact of entering and attending university on diabetes self-care in students with Type 1 diabetes in all UK universities. METHODS: Some 1865 current UK university students aged 18-24 years with Type 1 diabetes, were invited to complete a structured questionnaire. The association between demographic variables and diabetes variables was assessed using logistic regression models...
April 23, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29680499/corrigendum-to-hepatitis-c-virus-drug-resistance-associated-substitutions-and-their-clinical-relevance-update-2018-drug-resist-updates-37-march-2018-17-39
#7
Maria C Sorbo, Valeria Cento, Velia C Di Maio, Anita Y M Howe, Federico Garcia, Carlo F Perno, Francesca Ceccherini-Silberstein
No abstract text is available yet for this article.
April 18, 2018: Drug Resistance Updates: Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
https://www.readbyqxmd.com/read/29678121/the-relationship-between-adverse-neighborhood-socioeconomic-context-and-hiv-continuum-of-care-outcomes-in-a-diverse-hiv-clinic-cohort-in-the-southern-united-states
#8
Peter F Rebeiro, Chanelle J Howe, William B Rogers, Sally S Bebawy, Megan Turner, Asghar Kheshti, Catherine C McGowan, Stephen P Raffanti, Timothy R Sterling
Retention in care and viral suppression are critical to delaying HIV progression and reducing transmission. Neighborhood socioeconomic context (NSEC) may affect HIV care receipt. We therefore assessed NSEC's impact on retention and viral suppression in a diverse HIV clinical cohort. HIV-positive adults with ≥1 visit at the Vanderbilt Comprehensive Care Clinic and 5-digit ZIP code tabulation area (ZCTA) information between 2008 and 2012 contributed. NSEC z-score indices used neighborhood-level socioeconomic indicators for poverty, education, labor-force participation, proportion of males, median age, and proportion of residents of black race by ZCTA...
April 20, 2018: AIDS Care
https://www.readbyqxmd.com/read/29676732/donated-chemical-probes-for-open-science
#9
Susanne Müller, Suzanne Ackloo, Cheryl H Arrowsmith, Marcus Bauser, Jeremy L Baryza, Julian Blagg, Jark Böttcher, Chas Bountra, Peter J Brown, Mark E Bunnage, Adrian J Carter, David Damerell, Volker Dötsch, David H Drewry, Aled M Edwards, James Edwards, Jon M Elkins, Christian Fischer, Stephen V Frye, Andreas Gollner, Charles E Grimshaw, Adriaan IJzerman, Thomas Hanke, Ingo V Hartung, Steve Hitchcock, Trevor Howe, Terry V Hughes, Stefan Laufer, Volkhart Mj Li, Spiros Liras, Brian D Marsden, Hisanori Matsui, John Mathias, Ronan C O'Hagan, Dafydd R Owen, Vineet Pande, Daniel Rauh, Saul H Rosenberg, Bryan L Roth, Natalie S Schneider, Cora Scholten, Kumar Singh Saikatendu, Anton Simeonov, Masayuki Takizawa, Chris Tse, Paul R Thompson, Daniel K Treiber, Amélia Yi Viana, Carrow I Wells, Timothy M Willson, William J Zuercher, Stefan Knapp, Anke Mueller-Fahrnow
Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical industry has generated many high-quality chemical probes and several of these have been made available to academia. However, probe-associated data and control compounds, such as inactive structurally related molecules and their associated data, are generally not accessible. The lack of data and guidance makes it difficult for researchers to decide which chemical tools to choose...
April 20, 2018: ELife
https://www.readbyqxmd.com/read/29667676/functional-inks-and-printing-of-two-dimensional-materials
#10
REVIEW
Guohua Hu, Joohoon Kang, Leonard W T Ng, Xiaoxi Zhu, Richard C T Howe, Christopher G Jones, Mark C Hersam, Tawfique Hasan
Graphene and related two-dimensional materials provide an ideal platform for next generation disruptive technologies and applications. Exploiting these solution-processed two-dimensional materials in printing can accelerate this development by allowing additive patterning on both rigid and conformable substrates for flexible device design and large-scale, high-speed, cost-effective manufacturing. In this review, we summarise the current progress on ink formulation of two-dimensional materials and the printable applications enabled by them...
April 18, 2018: Chemical Society Reviews
https://www.readbyqxmd.com/read/29664106/effect-of-therapeutic-exercise-on-knee-osteoarthritis-after-intra-articular-injection-of-botulinum-toxin-type-a-hyaluronate-or-saline-a-randomized-controlled-trial
#11
Xiao Bao, Jie-Wen Tan, Michael Flyzik, Xian-Cong Ma, Howe Liu, Hui-Yu Liu
OBJECTIVE: To study the effect of therapeutic exercise on knee osteoarthritis after injection of botulinum toxin type A, hyaluronate or saline. METHODS: Sixty participants with knee osteoarthritis were randomly assigned to 3 groups: injection of saline (control) (group A), botulinum toxin type A (group B), or hyaluronate (group C). All participants received therapeutic exercise. Western Ontario and McMaster Universities Osteoarthritis Index questionnaire score, visual analogue scale pain scale, and Medical Outcomes Study 36-item Health Survey were conducted at baseline, and at the end of the 4th and 8th weeks...
April 17, 2018: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29663404/do-psychopathic-birds-of-a-feather-flock-together-psychopathic-personality-traits-and-romantic-preferences
#12
Ashley L Watts, Jessica C Rohr, Katherine L McCauley, Sarah Francis Smith, Kristin Landfield Howe, Scott O Lilienfeld
OBJECTIVE: The goal of the present studies was to investigate whether people are especially attracted to psychopathic traits, and whether there are individual differences characteristics in such attraction. METHOD: Female undergraduates (N = 270; Mage = 19; 57% White, 20% Asian, 8% Black) and female and male community members (N = 426, Mage = 37; 56% female; 81% Caucasian, 10% African American, 4% Asian) reported on their own personality and constructed their ideal mate for a dating, short-term, and long-term relationship from a list of 70 characteristics drawn from well-validated criteria for psychopathic personality and diagnostic criteria for DSM-5 personality disorders (PDs)...
April 16, 2018: Journal of Personality
https://www.readbyqxmd.com/read/29649509/cybersickness-related-changes-in-brain-hemodynamics-a-pilot-study-comparing-transcranial-doppler-and-near-infrared-spectroscopy-assessments-during-a-virtual-ride-on-a-roller-coaster
#13
Alireza Mazloumi Gavgani, Rachel H X Wong, Peter R C Howe, Deborah M Hodgson, Frederick R Walker, Eugene Nalivaiko
Our aim was to assess cerebral blood flow changes during cybersickness. Transcranial Doppler (TCD) ultrasound and near infrared spectroscopy (NIRS) were used separately in two independent experiments. In both studies, a 15-min virtual roller coaster ride was used as a provocative visual stimulus. Subjective nausea ratings were obtained at 1 min intervals. The TCD study was performed in 14 healthy subjects (8 males and 6 females); in this study we also measured heart rate and arterial pressure. In a separate study a 52-channel NIRS device (Hitachi ETG-4000) was used to monitor activated brain regions by measuring oxy-hemoglobin (HbO2) concentration in 9 healthy subjects (4 male, 5 females)...
April 9, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29624071/four-gene-pan-african-blood-signature-predicts-progression-to-tuberculosis
#14
Sara Suliman, Ethan Thompson, Jayne Sutherland, January Weiner Rd, Martin O C Ota, Smitha Shankar, Adam Penn-Nicholson, Bonnie Thiel, Mzwandile Erasmus, Jeroen Maertzdorf, Fergal J Duffy, Philip C Hill, E Jane Hughes, Kim Stanley, Katrina Downing, Michelle L Fisher, Joe Valvo, Shreemanta K Parida, Gian van der Spuy, Gerard Tromp, Ifedayo M O Adetifa, Simon Donkor, Rawleigh Howe, Harriet Mayanja-Kizza, W Henry Boom, Hazel Dockrell, Tom H M Ottenhoff, Mark Hatherill, Alan Aderem, Willem A Hanekom, Thomas J Scriba, Stefan He Kaufmann, Daniel E Zak, Gerhard Walzl
RATIONALE: Contacts of tuberculosis (TB) patients constitute an important target population for preventative measures as they are at high risk of infection with Mycobacterium tuberculosis and progression to disease. OBJECTIVES: We investigated biosignatures with predictive ability for incident tuberculosis. METHODS: In a case-control study nested within the Grand Challenges 6-74 longitudinal HIV-negative African cohort of exposed household contacts, we employed RNA sequencing, polymerase chain reaction (PCR) and the Pair Ratio algorithm in a training/test set approach...
April 6, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29605562/the-impact-of-interruptions-on-chest-radiograph-interpretation-effects-on-reading-time-and-accuracy
#15
Rachel M Wynn, Jessica L Howe, Linda C Kelahan, Allan Fong, Ross W Filice, Raj M Ratwani
RATIONALE AND OBJECTIVES: The objective of this study was to experimentally test the effect of interruptions on image interpretation by comparing reading time and response accuracy of interrupted case reads to uninterrupted case reads in resident and attending radiologists. MATERIALS AND METHODS: Institutional review board approval was obtained before participant recruitment from an urban academic health-care system during January 2016-March 2016. Eleven resident and 12 attending radiologists examined 30 chest radiographs, rating their confidence regarding the presence or the absence of a pneumothorax...
March 28, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29601399/reply-to-the-letter-to-the-editor-stem-cells-combined-with-platelet-rich-plasma-effectively-treat-corticosteroid-induced-osteonecrosis-of-the-hip-a-prospective-study
#16
Matthew T Houdek, Cody C Wyles, Mark S Collins, Benjamin M Howe, Andre Terzic, Atta Behfar, Rafael J Sierra
No abstract text is available yet for this article.
March 28, 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29599543/corrigendum-assessing-national-biodiversity-trends-for-rocky-and-coral-reefs-through-the-integration-of-citizen-science-and-scientific-monitoring-programs
#17
Rick D Stuart-Smith, Graham J Edgar, Neville S Barrett, Amanda E Bates, Susan C Baker, Nicholas J Bax, Mikel A Becerro, Just Berkhout, Julia L Blanchard, Daniel J Brock, Graeme F Clark, Antonia T Cooper, Tom R Davis, Paul B Day, J Emmett Duffy, Thomas H Holmes, Steffan A Howe, Alan Jordan, Stuart Kininmonth, Nathan A Knott, Jonathan S Lefcheck, Scott D Ling, Amanda Parr, Elisabeth Strain, Hugh Sweatman, Russell Thomson
[This corrects the article DOI: 10.1093/biosci/biw180.].
August 1, 2017: Bioscience
https://www.readbyqxmd.com/read/29575610/a-red-cell-preservation-strategy-reduces-postoperative-transfusions-in-pediatric-heart-surgery-patients
#18
Meena Nathan, Brielle Tishler, Kimberlee Gauvreau, Gregory S Matte, Robert J Howe, Linda Durham, Sharon Boyle, Derek Mathieu, Francis Fynn-Thompson, James A DiNardo, Juan C Ibla
BACKGROUND: Blood transfusion has well-documented adverse effects. As part of a blood conservation initiative at our center, we began routine use of cell saver for all congenital heart surgery performed on cardiopulmonary bypass since 2014. AIMS: This study aimed to compare transfusion rates prior to, and in the first and second year after this initiative. We hypothesized that cell saver use would decrease transfusion requirements in second year after use of the cell saver compared to the pre cell saver group...
March 25, 2018: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29574124/providing-level-of-match-information-to-perfectly-matched-unrelated-donors-evaluating-acceptability-and-potential-changes-in-donor-availability
#19
Galen E Switzer, Mario Macis, Rachel Fabi, Linda Abress, Dennis Confer, Jessica Bruce, Katie Howe, Sarah Fowler, Mary McNulty, Gabrielle Pastorek, Mary Amanda Dew
Patients with blood-related diseases often cannot identify a matched related donor and must seek donors in unrelated donor registries. These registries face the challenge of ensuring that potential donors are available when contacted. Donor attrition is especially problematic when there is only a single perfectly matched potential donor. One way to improve donor availability might be to present perfectly matched donors (high-priority donors [HPDs]) with more precise information about their match status. This project evaluated the impact of providing such information to HPDs at the National Marrow Donor Program (NMDP)/Be The Match...
March 21, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29563166/repeat-associated-mechanisms-of-genome-evolution-and-function-revealed-by-the-mus-caroli-and-mus-pahari-genomes
#20
David Thybert, Maša Roller, Fábio C P Navarro, Ian Fiddes, Ian Streeter, Christine Feig, David Martin-Galvez, Mikhail Kolmogorov, Václav Janoušek, Wasiu Akanni, Bronwen Aken, Sarah Aldridge, Varshith Chakrapani, William Chow, Laura Clarke, Carla Cummins, Anthony Doran, Matthew Dunn, Leo Goodstadt, Kerstin Howe, Matthew Howell, Ambre-Aurore Josselin, Robert C Karn, Christina M Laukaitis, Lilue Jingtao, Fergal Martin, Matthieu Muffato, Stefanie Nachtweide, Michael A Quail, Cristina Sisu, Mario Stanke, Klara Stefflova, Cock Van Oosterhout, Frederic Veyrunes, Ben Ward, Fengtang Yang, Golbahar Yazdanifar, Amonida Zadissa, David J Adams, Alvis Brazma, Mark Gerstein, Benedict Paten, Son Pham, Thomas M Keane, Duncan T Odom, Paul Flicek
Understanding the mechanisms driving lineage-specific evolution in both primates and rodents has been hindered by the lack of sister clades with a similar phylogenetic structure having high-quality genome assemblies. Here, we have created chromosome-level assemblies of the Mus caroli and Mus pahari genomes. Together with the Mus musculus and Rattus norvegicus genomes, this set of rodent genomes is similar in divergence times to the Hominidae (human-chimpanzee-gorilla-orangutan). By comparing the evolutionary dynamics between the Muridae and Hominidae, we identified punctate events of chromosome reshuffling that shaped the ancestral karyotype of Mus musculus and Mus caroli between 3 and 6 million yr ago, but that are absent in the Hominidae...
April 2018: Genome Research
keyword
keyword
1928
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"