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https://www.readbyqxmd.com/read/29328510/a-multidimensional-assessment-of-the-burden-of-psoriasis-results-from-a-multinational-dermatologist-and-patient-survey
#1
C E M Griffiths, S J Jo, L Naldi, R Romiti, E Guevara-Sangines, T Howe, G Pietri, I Gilloteau, C Richardson, H Tian, M Augustin
BACKGROUND: Psoriasis is a chronic, immune-mediated disease, characterised by symptoms that include itching and skin pain and is often associated with comorbidities. Patients have a substantial detriment to quality of life (QoL) and work productivity with associated cost burden. OBJECTIVE: To investigate the incremental burden of comorbidities, itch, and affected body areas among systemic eligible patients with psoriasis, using a multinational survey of dermatologists and their psoriasis patients...
January 12, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29315164/effects-of-strength-training-on-postpubertal-adolescent-distance-runners
#2
Richard C Blagrove, Louis P Howe, Emily J Cushion, Adam Spence, Glyn Howatson, Charles R Pedlar, Philip R Hayes
PURPOSE: Strength training activities have consistently been shown to improve running economy (RE) and neuromuscular characteristics, such as force producing ability and maximal speed, in adult distance runners. However the effects on adolescent (<18 years) runners remains elusive. This randomized control trial aimed to examine the effect of strength training on several important physiological and neuromuscular qualities associated with distance running performance. METHODS: Participants (n=25, 13 female, 17...
January 8, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29289169/prospects-for-magnetic-field-communications-and-location-using-quantum-sensors
#3
V Gerginov, F C S da Silva, D Howe
Signal attenuation limits the operating range in wireless communications and location. To solve the reduced range problem, we can use low-frequency signals in combination with magnetic sensing. We propose the use of an optically pumped magnetometer as a sensor and realize a proof-of-principle detection of binary phase shift keying (BPSK) modulated signals. We demonstrate a ranging enhancement by exploiting both the magnetometer's intrinsic sensitivity of below 1 pT/Hz1/2 and its 1 kHz operating bandwidth through the use of BPSK signals...
December 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29261676/parenting-style-and-family-type-but-not-child-temperament-are-associated-with-television-viewing-time-in-children-at-two-years-of-age
#4
Anna S Howe, Anne-Louise M Heath, Julie Lawrence, Barbara C Galland, Andrew R Gray, Barry J Taylor, Rachel Sayers, Rachael W Taylor
OBJECTIVES: Despite the American Academy of Pediatrics (AAP) recommending that electronic media be avoided in children under two years of age, screen use is common in infants and toddlers. The aims of this study were to determine how parenting style, infant temperament, and family type are associated with television viewing in two-year-old children. STUDY DESIGN: Participants were from the Prevention of Overweight in Infancy (POI) randomized controlled trial (n = 802) (Dunedin, New Zealand)...
2017: PloS One
https://www.readbyqxmd.com/read/29249046/generation-of-transgenic-goats-by-pronuclear-microinjection-a-retrospective-analysis-of-a-commercial-operation-1995-2012
#5
W Gavin, S Blash, N Buzzell, D Pollock, L Chen, N Hawkins, J Howe, K Miner, J Pollock, C Porter, M Schofield, Y Echelard, H Meade
Production of transgenic founder goats involves introducing and stably integrating an engineered piece of DNA into the genome of the animal. At LFB USA, the ultimate use of these transgenic goats is for the production of recombinant human protein therapeutics in the milk of these dairy animals. The transgene or construct typically links a milk protein specific promoter sequence, the coding sequence for the gene of interest, and the necessary downstream regulatory sequences thereby directing expression of the recombinant protein in the milk during the lactation period...
December 16, 2017: Transgenic Research
https://www.readbyqxmd.com/read/29248210/results-of-an-international-comparison-of-activity-measurements-of-68ge
#6
J T Cessna, R Fitzgerald, B E Zimmerman, L Laureano-Pérez, D E Bergeron, F van Wyngaardt, M Smith, T Jackson, B Howe, C J da Silva, A Iwahara, P A L da Cruz, M Zhang, H Liu, J Liang, C Fréchou, C Bobin, P Cassette, K Kossert, O Nähle, J Marganiec-Gałązka, L Joseph, A Ravindra, D N Kulkarni, A Yunoki, Y Sato, K B Lee, J M Lee, Agung, T Dziel, A Listkowska, Z Tymiński, M Sahagia, A Antohe, M-R Ioan, A Luca, M Krivosek, J Ometakova, A Javornik, M Zalesakova, E García-Toraño Martinez, M Roteta, M Mejuto, Y Nedjadi, F Juget, M-C Yuan, C Y Yeh, E Yeltepe, A Dirican, J Keightley, A Pearce
An international key comparison, identifier CCRI(II)-K2.Ge-68, has been performed. The National Institute of Standards and Technology (NIST) served as the pilot laboratory, distributing aliquots of a 68Ge/68Ga solution. Results for the activity concentration, CA, of 68Ge at a reference date of 12h00 UTC 14 November 2014 were submitted by 17 laboratories, encompassing many variants of coincidence methods and liquid-scintillation counting methods. The first use of 4π(Cherenkov)β-γ coincidence and anticoincidence methods in an international comparison is reported...
November 7, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29226592/comment-on-hopwood-et-al-the-time-has-come-for-dimensional-personality-disorder-diagnosis
#7
Steven K Huprich, Sabine C Herpertz, Martin Bohus, Andrew Chanen, Marianne Goodman, Lars Mehlum, Paul Moran, Giles Newton-Howe, Lori Scott, Carla Sharp
No abstract text is available yet for this article.
December 11, 2017: Personality and Mental Health
https://www.readbyqxmd.com/read/29209514/fish-oil-supplementation-in-chronic-obstructive-pulmonary-disease-feasibility-of-conducting-a-randomised-controlled-trial
#8
Ashley S Fulton, Alison M Coates, Marie T Williams, Peter R C Howe, Manohar L Garg, Lisa G Wood, Peter Frith, Alison M Hill
Background: Long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFAs) may act as an effective adjunct therapy for chronic obstructive pulmonary disease (COPD), a condition characterised by persistent airflow limitation and inflammation. However, the nature of this illness presents challenges for evaluating potential benefits. The aim of this study was to determine the feasibility of undertaking a randomised controlled trial of LCn-3PUFA supplementation in adults with COPD. Methods: A 16-week parallel, double-blind, randomised, placebo-controlled dietary supplementation trial was conducted...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29205741/standoff-mid-infrared-emissive-imaging-spectroscopy-to-identify-and-map-materials-in-polychrome-objects
#9
Francesca Gabrieli, Kathryn A Dooley, Jason G Zeibel, James D Howe, John Delaney
Microscale mid-infrared (mid-IR) imaging spectroscopy is used for mapping chemical functional groups. The extension to macroscale imaging requires either the mid-IR radiation reflected off or emitted by the object be greater than the radiation from the thermal background. Reflectance spectra can be obtained using an active IR source to increase the amount of radiation reflected off the object, but rapid heating >4 C can occur, a problem for paintings. Rather than using an active source, by placing a highly reflective tube between the painting and camera and introducing a low temperature source, thermal radiation from the room can be reduced, allowing the IR radiation emitted by the painting to dominate...
December 4, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29202258/the-spice-iii-study-protocol-and-analysis-plan-a-randomised-trial-of-early-goaldirected-sedation-compared-with-standard-care-in-mechanically-ventilated-patients
#10
RANDOMIZED CONTROLLED TRIAL
Yahya Shehabi, Andrew B Forbes, Yaseen Arabi, Frances Bass, Rinaldo Bellomo, Suhaini Kadiman, Belinda D Howe, Colin McArthur, Michael C Reade, Ian Seppelt, Jukka Takala, Steve Webb, Matthew P Wise
BACKGROUND: Sedation strategy in critically ill patients who are mechanically ventilated is influenced by patient-related factors, choice of sedative agent and the intensity or depth of sedation prescribed. The impact of sedation strategy on outcome, in particular when delivered early after initiation of mechanical ventilation, is uncertain. OBJECTIVES: To present the protocol and analysis plan of a large randomised clinical trial investigating the effect of a sedation strategy, in critically ill patients who are mechanically ventilated, based on a protocol targeting light sedation using dexmedetomidine as the primary sedative, termed "early goal-directed sedation", compared with usual practice...
December 2017: Critical Care and Resuscitation: Journal of the Australasian Academy of Critical Care Medicine
https://www.readbyqxmd.com/read/29174886/a-new-lineage-of-eukaryotes-illuminates-early-mitochondrial-genome-reduction
#11
Jan Janouškovec, Denis V Tikhonenkov, Fabien Burki, Alexis T Howe, Forest L Rohwer, Alexander P Mylnikov, Patrick J Keeling
The origin of eukaryotic cells represents a key transition in cellular evolution and is closely tied to outstanding questions about mitochondrial endosymbiosis [1, 2]. For example, gene-rich mitochondrial genomes are thought to be indicative of an ancient divergence, but this relies on unexamined assumptions about endosymbiont-to-host gene transfer [3-5]. Here, we characterize Ancoracysta twista, a new predatory flagellate that is not closely related to any known lineage in 201-protein phylogenomic trees and has a unique morphology, including a novel type of extrusome (ancoracyst)...
December 4, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/29172051/dna-methylation-from-birth-to-late-adolescence-and-development-of-multiple-risk-behaviours
#12
F de Vocht, M Suderman, K Tilling, J Heron, L D Howe, R Campbell, M Hickman, C Relton
BACKGROUND: Risk behaviours in adolescence are linked to poor educational attainment and health and other outcomes in young adulthood. We explored whether there are molecular mechanisms associated with the development, or the result, of multiple risk behaviours (MRBs). METHODS: MRBs (antisocial behaviour and delinquency, traffic-related risk behaviour, risky sexual behaviour, lack of exercise) and their sumscore were characterized based on self-reported questions at age 7 and 17 within the ARIES subsample of the ALSPAC birth cohort, and were linked to DNA methylation at over 485,000 CpG sites at ages 0,7 and 17...
November 15, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29152164/mutations-in-rab39b-in-individuals-with-intellectual-disability-autism-spectrum-disorder-and-macrocephaly
#13
Marc Woodbury-Smith, Eric Deneault, Ryan K C Yuen, Susan Walker, Mehdi Zarrei, Giovanna Pellecchia, Jennifer L Howe, Ny Hoang, Mohammed Uddin, Christian R Marshall, Christina Chrysler, Ann Thompson, Peter Szatmari, Stephen W Scherer
Background: Autism spectrum disorder (ASD), a developmental disorder of early childhood onset, affects males four times more frequently than females, suggesting a role for the sex chromosomes. In this study, we describe a family with ASD in which a predicted pathogenic nonsense mutation in the X-chromosome gene RAB39B segregates with ASD phenotype. Methods: Clinical phenotyping, microarray, and whole genome sequencing (WGS) were performed on the five members of this family...
2017: Molecular Autism
https://www.readbyqxmd.com/read/29135081/adverse-childhood-experiences-aces-and-adiposity-in-adolescents-a-cross-cohort-comparison
#14
Ana Luiza G Soares, Alicia Matijasevich, Ana M B Menezes, Maria Cecília Assunção, Fernando C Wehrmeister, Laura D Howe, Helen Gonçalves
OBJECTIVE: This study aimed to assess the association between adverse childhood experiences (ACEs) and adiposity in adolescents from two cohorts in different socioeconomic contexts. METHODS: Data from the Avon Longitudinal Study of Parents and Children (ALSPAC, United Kingdom) and the 1993 Pelotas Cohort (Brazil) were used. Six ACEs were assessed in both cohorts up to age 15. At 15 years, body mass index (BMI) and waist circumference (WC) were measured, and at 18 years, BMI, fat mass index, and android fat percentage were assessed...
November 14, 2017: Obesity
https://www.readbyqxmd.com/read/29129367/injection-of-bulking-agents-for-laryngoplasty
#15
Samuel K Snyder, Peter Angelos, Sally E Carty, Gerard M Doherty, James R Howe, James A Lee, Steven K Libutti, Barbra S Miller, Sareh Parangi, Kepal N Patel, Rebecca C Sippel, Cord Sturgeon, Tracy S Wang, Linwah Yip, Martha A Zeiger
No abstract text is available yet for this article.
November 9, 2017: Surgery
https://www.readbyqxmd.com/read/29122994/childhood-psychosocial-adversity-and-female-reproductive-timing-a-cohort-study-of-the-alspac-mothers
#16
Maria C Magnus, Emma L Anderson, Laura D Howe, Carol J Joinson, Ian S Penton-Voak, Abigail Fraser
BACKGROUND: Previous studies of childhood psychosocial adversity and age at menarche mostly evaluated single or a few measures of adversity, and therefore could not quantify total psychosocial adversity. Limited knowledge is currently available regarding childhood psychosocial adversity in relation to age at menopause and reproductive lifespan. METHODS: We examined the associations of total and specific components of childhood psychosocial adversity with age at menarche (n=8984), age at menopause (n=945), and length of reproductive lifespan (n=841), in mothers participating in the Avon Longitudinal Study of Parents and Children...
January 2018: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/29102868/associations-of-adversity-in-childhood-and-risk-factors-for-cardiovascular-disease-in-mid-adulthood
#17
Emma L Anderson, Abigail Fraser, Rishi Caleyachetty, Rebecca Hardy, Debbie A Lawlor, Laura D Howe
Studies assessing associations of childhood psychosocial adversity (e.g. sexual abuse, physical neglect, parental death), as opposed to socioeconomic adversity, with cardiovascular disease (CVD) risk factors in adulthood are scarce. The aim of this study is to assess associations of various types of psychosocial adversity and cumulative adversity in childhood, with multiple CVD risk factors in mid-life. At study enrolment, women from the Avon Longitudinal Study of Parents and Children (N=3612) retrospectively reported: lack of maternal care, maternal overprotection, parental mental illness, household dysfunction, sexual abuse, physical and emotional abuse, and neglect in childhood...
November 2, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29069345/adaptive-evolution-under-extreme-genetic-drift-in-oxidatively-stressed-caenorhabditis-elegans
#18
Stephen F Christy, Riana I Wernick, Michael J Lue, Griselda Velasco, Dana K Howe, Dee R Denver, Suzanne Estes
A mutation-accumulation (MA) experiment with Caenorhabditis elegans nematodes was conducted in which replicate, independently evolving lines were initiated from a low-fitness mitochondrial electron transport chain mutant, gas-1. The original intent of the study was to assess the effect of electron transport chain dysfunction involving elevated reactive oxygen species production on patterns of spontaneous germline mutation. In contrast to results of standard MA experiments, gas-1 MA lines evolved slightly higher mean fitness alongside reduced among-line genetic variance compared with their ancestor...
November 1, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29062526/learning-to-work-together-lessons-from-a-reflective-analysis-of-a-research-project-on-public-involvement
#19
A Howe, E Mathie, D Munday, M Cowe, C Goodman, J Keenan, S Kendall, F Poland, S Staniszewska, P Wilson
PLAIN ENGLISH SUMMARY: Patient and public involvement (PPI) in research is very important, and funders and the NHS all expect this to happen. What this means in practice, and how to make it really successful, is therefore an important research question. This article analyses the experience of a research team using PPI, and makes recommendations on strengthening PPI in research. There were different PPI roles in our study - some people were part of the research team: some were on the advisory group; and there were patient groups who gave specific feedback on how to make research work better for their needs...
2017: Research Involvement and Engagement
https://www.readbyqxmd.com/read/29049141/review-of-setting-performance-standards-for-technical-and-nontechnical-competence-in-general-surgery-by-szasz-p-bonrath-em-louridas-m-fesco-ab-howe-b-fehr-a-ott-m-mack-la-harris-ka-grantcharov-tp-in-ann-surg-266-1-7-2017-and-beyond-measure-twice-new-performance
#20
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