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https://www.readbyqxmd.com/read/28295311/molecular-phylogeny-and-taxonomic-revision-of-the-genus-wittrockiella-pithophoraceae-cladophorales-including-the-descriptions-of-w-australis-sp-nov-and-w-zosterae-sp-nov
#1
Christian Boedeker, Charles J O'Kelly, John A West, Takeaki Hanyuda, Adele Neale, Isamu Wakana, Mike D Wilcox, Ulf Karsten, Giuseppe C Zuccarello
Wittrockiella is a small genus of filamentous green algae that occurs in habitats with reduced or fluctuating salinities. Many aspects of the basic biology of these algae are still unknown and the phylogenetic relationships within the genus have not been fully explored. We provide a phylogeny based on three ribosomal markers (ITS, LSU and SSU rDNA) of the genus, including broad intraspecific sampling for W. lyallii and W. salina, recommendations for the use of existing names are made, and highlight aspects of their physiology and life cycle...
March 12, 2017: Journal of Phycology
https://www.readbyqxmd.com/read/28287407/membrane-organizing-protein-moesin-controls-treg-differentiation-and-antitumor-immunity-via-tgf-%C3%AE-signaling
#2
Ephraim A Ansa-Addo, Yongliang Zhang, Yi Yang, George S Hussey, Breege V Howley, Mohammad Salem, Brian Riesenberg, Shaoli Sun, Don C Rockey, Serhan Karvar, Philip H Howe, Bei Liu, Zihai Li
Moesin is a member of the ezrin-radixin-moesin (ERM) family of proteins that are important for organizing membrane domains and receptor signaling and regulating the migration of effector T cells. Whether moesin plays any role during the generation of TGF-β-induced Tregs (iTregs) is unknown. Here, we have discovered that moesin is translationally regulated by TGF-β and is also required for optimal TGF-β signaling that promotes efficient development of iTregs. Loss of moesin impaired the development and function of both peripherally derived iTregs and in vitro-induced Tregs...
March 13, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28287159/double-wall-carbon-nanotube-hybrid-mode-locker-in-tm-doped-fibre-laser-a-novel-mechanism-for-robust-bound-state-solitons-generation
#3
Maria Chernysheva, Anastasia Bednyakova, Mohammed Al Araimi, Richard C T Howe, Guohua Hu, Tawfique Hasan, Alessio Gambetta, Gianluca Galzerano, Mark Rümmeli, Aleksey Rozhin
The complex nonlinear dynamics of mode-locked fibre lasers, including a broad variety of dissipative structures and self-organization effects, have drawn significant research interest. Around the 2 μm band, conventional saturable absorbers (SAs) possess small modulation depth and slow relaxation time and, therefore, are incapable of ensuring complex inter-pulse dynamics and bound-state soliton generation. We present observation of multi-soliton complex generation in mode-locked thulium (Tm)-doped fibre laser, using double-wall carbon nanotubes (DWNT-SA) and nonlinear polarisation evolution (NPE)...
March 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28282956/effects%C3%A2-of%C3%A2-resveratrol%C3%A2-supplementation%C3%A2-on%C3%A2-methotrexate%C3%A2-chemotherapy-induced%C3%A2-bone%C3%A2-loss
#4
Alice M C Lee, Tetyana Shandala, Pei Pei Soo, Yu-Wen Su, Tristan J King, Ke-Ming Chen, Peter R Howe, Cory J Xian
Intensive cancer chemotherapy is known to cause bone defects, which currently lack treatments. This study investigated the effects of polyphenol resveratrol (RES) in preventing bone defects in rats caused by methotrexate (MTX), a commonly used antimetabolite in childhood oncology. Young rats received five daily MTX injections at 0.75 mg/kg/day. RES was orally gavaged daily for seven days prior to, and during, five-day MTX administration. MTX reduced growth plate thickness, primary spongiosa height, trabecular bone volume, increased marrow adipocyte density, and increased mRNA expression of the osteogenic, adipogenic, and osteoclastogenic factors in the tibial bone...
March 9, 2017: Nutrients
https://www.readbyqxmd.com/read/28277699/harnessing-the-placebo-effect-exploring-the-influence-of-physician-characteristics-on-placebo-response
#5
Lauren C Howe, J Parker Goyer, Alia J Crum
OBJECTIVE: Research on placebo/nocebo effects suggests that expectations can influence treatment outcomes, but placebo/nocebo effects are not always evident. This research demonstrates that a provider's social behavior moderates the effect of expectations on physiological outcomes. METHODS: After inducing an allergic reaction in participants through a histamine skin prick test, a health care provider administered a cream with no active ingredients and set either positive expectations (cream will reduce reaction) or negative expectations (cream will increase reaction)...
March 9, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/28263302/whole-genome-sequencing-resource-identifies-18-new-candidate-genes-for-autism-spectrum-disorder
#6
Ryan K C Yuen, Daniele Merico, Matt Bookman, Jennifer L Howe, Bhooma Thiruvahindrapuram, Rohan V Patel, Joe Whitney, Nicole Deflaux, Jonathan Bingham, Zhuozhi Wang, Giovanna Pellecchia, Janet A Buchanan, Susan Walker, Christian R Marshall, Mohammed Uddin, Mehdi Zarrei, Eric Deneault, Lia D'Abate, Ada J S Chan, Stephanie Koyanagi, Tara Paton, Sergio L Pereira, Ny Hoang, Worrawat Engchuan, Edward J Higginbotham, Karen Ho, Sylvia Lamoureux, Weili Li, Jeffrey R MacDonald, Thomas Nalpathamkalam, Wilson W L Sung, Fiona J Tsoi, John Wei, Lizhen Xu, Anne-Marie Tasse, Emily Kirby, William Van Etten, Simon Twigger, Wendy Roberts, Irene Drmic, Sanne Jilderda, Bonnie MacKinnon Modi, Barbara Kellam, Michael Szego, Cheryl Cytrynbaum, Rosanna Weksberg, Lonnie Zwaigenbaum, Marc Woodbury-Smith, Jessica Brian, Lili Senman, Alana Iaboni, Krissy Doyle-Thomas, Ann Thompson, Christina Chrysler, Jonathan Leef, Tal Savion-Lemieux, Isabel M Smith, Xudong Liu, Rob Nicolson, Vicki Seifer, Angie Fedele, Edwin H Cook, Stephen Dager, Annette Estes, Louise Gallagher, Beth A Malow, Jeremy R Parr, Sarah J Spence, Jacob Vorstman, Brendan J Frey, James T Robinson, Lisa J Strug, Bridget A Fernandez, Mayada Elsabbagh, Melissa T Carter, Joachim Hallmayer, Bartha M Knoppers, Evdokia Anagnostou, Peter Szatmari, Robert H Ring, David Glazer, Mathew T Pletcher, Stephen W Scherer
We are performing whole-genome sequencing of families with autism spectrum disorder (ASD) to build a resource (MSSNG) for subcategorizing the phenotypes and underlying genetic factors involved. Here we report sequencing of 5,205 samples from families with ASD, accompanied by clinical information, creating a database accessible on a cloud platform and through a controlled-access internet portal. We found an average of 73.8 de novo single nucleotide variants and 12.6 de novo insertions and deletions or copy number variations per ASD subject...
March 6, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28243827/limitations-in-using-multiple-imputation-to-harmonize-individual-participant-data-for-meta-analysis
#7
Juned Siddique, Peter J de Chavez, George Howe, Gracelyn Cruden, C Hendricks Brown
Individual participant data (IPD) meta-analysis is a meta-analysis in which the individual-level data for each study are obtained and used for synthesis. A common challenge in IPD meta-analysis is when variables of interest are measured differently in different studies. The term harmonization has been coined to describe the procedure of placing variables on the same scale in order to permit pooling of data from a large number of studies. Using data from an IPD meta-analysis of 19 adolescent depression trials, we describe a multiple imputation approach for harmonizing 10 depression measures across the 19 trials by treating those depression measures that were not used in a study as missing data...
February 27, 2017: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/28240939/healthier-than-thou-practicing-what-you-preach-backfires-by-increasing-anticipated-devaluation
#8
Lauren C Howe, Benoît Monin
Should experts always practice what they preach? When an expert displays exemplary behavior, individuals who fear negative devaluation sometimes anticipate that this expert will look down on them. As a result, displays of excellence can paradoxically turn off the very people they are trying to inspire. Five studies document this in the medical domain, showing that individuals who are overweight or obese and concerned about their weight avoid physicians who advertise their fitness, for fear that these doctors will judge them negatively...
February 27, 2017: Journal of Personality and Social Psychology
https://www.readbyqxmd.com/read/28199403/comparison-of-microbiological-diagnosis-of-urinary-tract-infection-in-young-children-by-routine-health-service-laboratories-and-a-research-laboratory-diagnostic-cohort-study
#9
Kate Birnie, Alastair D Hay, Mandy Wootton, Robin Howe, Alasdair MacGowan, Penny Whiting, Michael Lawton, Brendan Delaney, Harriet Downing, Jan Dudley, William Hollingworth, Catherine Lisles, Paul Little, Kathryn O'Brien, Timothy Pickles, Kate Rumsby, Emma Thomas-Jones, Judith Van der Voort, Cherry-Ann Waldron, Kim Harman, Kerenza Hood, Christopher C Butler, Jonathan A C Sterne
OBJECTIVES: To compare the validity of diagnosis of urinary tract infection (UTI) through urine culture between samples processed in routine health service laboratories and those processed in a research laboratory. POPULATION AND METHODS: We conducted a prospective diagnostic cohort study in 4808 acutely ill children aged <5 years attending UK primary health care. UTI, defined as pure/predominant growth ≥105 CFU/mL of a uropathogen (the reference standard), was diagnosed at routine health service laboratories and a central research laboratory by culture of urine samples...
2017: PloS One
https://www.readbyqxmd.com/read/28194458/an-assessment-of-hydrocarbon-species-in-the-methanol-to-hydrocarbon-reaction-over-a-zsm-5-catalyst
#10
Suwardiyanto, Russell F Howe, Emma K Gibson, C Richard A Catlow, Ali Hameed, James McGregor, Paul Collier, Stewart F Parker, David Lennon
A ZSM-5 catalyst is examined in relation to the methanol-to-hydrocarbon (MTH) reaction as a function of reaction temperature and time-on-stream. The reaction profile is characterised using in-line mass spectrometry. Furthermore, the material contained within a catch-pot downstream from the reactor is analysed using gas chromatography-mass spectrometry. For a fixed methanol feed, reaction conditions are selected to define various stages of the reaction coordinate: (i) initial methanol adsorption at a sub-optimum reaction temperature (1 h at 200 °C); (ii) initial stages of reaction at an optimised reaction temperature (1 h at 350 °C); (iii) steady-state operation at an optimised reaction temperature (3 days at 350 °C); and (iv) accelerated ageing (3 days at 400 °C)...
February 14, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28193518/safety-and-efficacy-of-elbasvir-grazoprevir-in-patients-with-hepatitis-c-virus-infection-and-compensated-cirrhosis-an-integrated-analysis
#11
Ira M Jacobson, Eric Lawitz, Paul Y Kwo, Christophe Hézode, Cheng-Yuan Peng, Anita Y M Howe, Peggy Hwang, Janice Wahl, Michael Robertson, Eliav Barr, Barbara A Haber
BACKGROUND & AIMS: Persons with hepatitis C virus (HCV) infection are at risk of progressive liver disease, cirrhosis, and decompensation. We analyzed the effects of the direct-acting antiviral agents elbasvir and grazoprevir in patients with HCV infection and compensated cirrhosis, combining data from 6 clinical trials. METHODS: We performed an integrated analysis of 402 patients with HCV genotype 1, 4, or 6 infection and Child-Pugh A compensated cirrhosis enrolled in 6 clinical trials...
February 10, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28177706/the-effects-of-acute-branched-chain-amino-acid-supplementation-on-recovery-from-a-single-bout-of-hypertrophy-exercise-in-resistance-trained-athletes
#12
Mark Waldron, Kieran Whelan, Owen Jeffries, Dean Burt, Louis Howe, Stephen David Patterson
This study investigated the effects of acute branched-chain amino acid (BCAA) supplementation on recovery from exercise-induced muscle damage, among experienced resistance-trained athletes. In a double-blind matched-pairs design, 16 resistance-trained participants, routinely performing hypertrophy training, were randomly assigned to a BCAA (n = 8) or placebo (n = 8) group. The BCAAs were administered at a dosage of 0.087 g/kg body mass, with a 2:1:1 ratio of leucine, isoleucine and valine. The participants performed 6 sets of 10 full-squats at 70 % 1RM to induce muscle damage...
January 27, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28164302/structural-and-functional-impacts-of-amino-acid-substitutions-that-create-blood-group-antigens-implications-for-immunogenicity
#13
John G Howe, Gary Stack
BACKGROUND: The immunogenicities of polypeptide blood group antigens vary widely. One possible determinant of immunogenicity is antigenic foreignness. The goal was to employ alternative ways of assessing foreignness and determine whether foreignness was related to immunogenicity. STUDY DESIGN AND METHODS: Foreignness was assessed as the extent of protein functional disruption caused by the exofacial amino acid (AA) substitutions that create blood group antigens, using AA substitution prediction algorithms such as Meta-SNP and according to whether those substitutions were radical or conservative...
March 2017: Transfusion
https://www.readbyqxmd.com/read/28152871/breast-cancer-specific-mortality-in-patients-with-early-stage-hormone-receptor-positive-invasive-breast-cancer-and-oncotype-dx-recurrence-score-results-in-the-seer-database
#14
Valentina Petkov, Dave P Miller, Nadia Howlader, Nathan Gliner, Will Howe, Nicola C Schussler, Kathleen Cronin, Frederick L Baehner, Lynne Penberthy
176 Background: NCI's SEER Program provides cancer incidence and survival statistics for ~28% of the US. New research models are needed to characterize the use and impact of genomic tests on patient outcomes. Genomic Health and SEER collaborated to electronically supplement SEER registries with Recurrence Score (RS) results, and have evaluated breast cancer specific mortality (BCSM) in early stage hormone receptor (HR)+ HER2- invasive breast cancer. METHODS: Pts were eligible for pre-specified node negative (N-) disease analysis if HR+, HER2- (by RT-PCR), no prior malignancy, 40-85 years of age, and diagnosed between Jan 2004 (Oncotype DX available Jan 2004) and Dec 2011 (SEER survival analysis complete through 2012)...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28137867/structural-insights-into-alternative-splicing-mediated-desensitization-of-jasmonate-signaling
#15
Feng Zhang, Jiyuan Ke, Li Zhang, Rongzhi Chen, Koichi Sugimoto, Gregg A Howe, H Eric Xu, Mingguo Zhou, Sheng Yang He, Karsten Melcher
Jasmonate ZIM-domain (JAZ) transcriptional repressors play a key role in regulating jasmonate (JA) signaling in plants. Below a threshold concentration of jasmonoyl isoleucine (JA-Ile), the active form of JA, the C-terminal Jas motif of JAZ proteins binds MYC transcription factors to repress JA signaling. With increasing JA-Ile concentration, the Jas motif binds to JA-Ile and the COI1 subunit of the SCF(COI1) E3 ligase, which mediates ubiquitination and proteasomal degradation of JAZ repressors, resulting in derepression of MYC transcription factors...
February 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28118373/the-role-of-adjuvant-acid-suppression-on-the-outcomes-of-bleeding-esophageal-varices-after-endoscopic-variceal-ligation
#16
Cheng-Kun Wu, Chih-Ming Liang, Chien-Ning Hsu, Tsung-Hsing Hung, Lan-Ting Yuan, Seng-Howe Nguang, Jiunn-Wei Wang, Kuo-Lun Tseng, Ming-Kun Ku, Shih-Cheng Yang, Wei-Chen Tai, Chih-Wei Shih, Pin-I Hsu, Deng-Chyang Wu, Seng-Kee Chuah
The impact of adjuvant acid suppression via proton pump inhibitors or histamine-2 receptor antagonists after endoscopic variceal ligation remains uncertain. We therefore aimed to evaluate the effect of adjuvant acid suppression on the rebleeding and mortality rates in patients who received endoscopic variceal ligation and vasoconstrictor therapy for bleeding esophageal varices. Data from 1997 to 2011 were extracted from the National Health Insurance Research Database in Taiwan. A total of 1576 cirrhotic patients aged > 18 years with a primary diagnosis of acute esophageal variceal bleeding who received endoscopic variceal ligation therapy were screened...
2017: PloS One
https://www.readbyqxmd.com/read/28069034/health-related-quality-of-life-and-unmet-healthcare-needs-in-huntington-s-disease
#17
Marleen R van Walsem, Emilie I Howe, Gunvor A Ruud, Jan C Frich, Nada Andelic
BACKGROUND: Huntington's disease (HD) is a rare neurodegenerative disorder with a prevalence of 6 per 100.000. Despite increasing research activity on HD, evidence on healthcare utilization, patients' needs for healthcare services and Health-Related Quality of Life (HRQoL) is still sparse. The present study describes HRQoL in a Norwegian cohort of HD patients, and assesses associations between unmet healthcare and social support service needs and HRQoL. METHODS: In this cross-sectional population-based study, 84 patients with a clinical diagnosis of HD living in the South-East of Norway completed the HRQoL questionnaire EuroQol, EQ-5D-3L...
January 7, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28065755/extended-spectrum-antiprotozoal-bumped-kinase-inhibitors-a-review
#18
Wesley C Van Voorhis, J Stone Doggett, Marilyn Parsons, Matthew A Hulverson, Ryan Choi, Samuel Arnold, Michael W Riggs, Andrew Hemphill, Daniel K Howe, Robert H Mealey, Audrey O T Lau, Ethan A Merritt, Dustin J Maly, Erkang Fan, Kayode K Ojo
Many life-cycle processes in parasites are regulated by protein phosphorylation. Hence, disruption of essential protein kinase function has been explored for therapy of parasitic diseases. However, the difficulty of inhibiting parasite protein kinases to the exclusion of host orthologues poses a practical challenge. A possible path around this difficulty is the use of bumped kinase inhibitors for targeting calcium dependent protein kinases that contain atypically small gatekeeper residues and are crucial for pathogenic apicomplexan parasites' survival and proliferation...
January 5, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28054939/effects-of-resveratrol-on-cognitive-performance-mood-and-cerebrovascular-function-in-post-menopausal-women-a-14-week-randomised-placebo-controlled-intervention-trial
#19
Hamish M Evans, Peter R C Howe, Rachel H X Wong
We tested whether chronic supplementation with resveratrol (a phytoestrogen) could improve cerebrovascular function, cognition and mood in post-menopausal women. Eighty post-menopausal women aged 45-85 years were randomised to take trans-resveratrol or placebo for 14 weeks and the effects on cognitive performance, cerebral blood flow velocity and pulsatility index (a measure of arterial stiffness) in the middle cerebral artery (using transcranial Doppler ultrasound), and cerebrovascular responsiveness (CVR) to both cognitive testing and hypercapnia were assessed...
January 3, 2017: Nutrients
https://www.readbyqxmd.com/read/28054821/multimodal-emotion-processing-deficits-are-present-in-amyotrophic-lateral-sclerosis
#20
Sophie C Andrews, Mathew Staios, Jim Howe, Katrina Reardon, Fiona Fisher
OBJECTIVE: Emotion processing abilities might be reduced in amyotrophic lateral sclerosis (ALS). Previous studies of emotion processing in ALS have inconsistent results, and are limited by variations in task difficulty, modalities examined, and participants' cognitive status. The current study used a battery of emotion processing tasks at differing levels of difficulty and across different modalities (facial affect and voice prosody) to assess the extent of emotion processing deficits in nondemented ALS...
March 2017: Neuropsychology
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