keyword
MENU ▼
Read by QxMD icon Read
search

Biomechanical properties vagina

keyword
https://www.readbyqxmd.com/read/28487243/towards-rebuilding-vaginal-support-utilizing-an-extracellular-matrix-bioscaffold
#1
Rui Liang, Katrina Knight, Deanna Easley, Stacy Palcsey, Steven Abramowitch, Pamela A Moalli
As an alternative to polypropylene mesh, we explored an extracellular matrix (ECM) bioscaffold derived from urinary bladder matrix (MatriStem™) in the repair of vaginal prolapse. We aimed to restore disrupted vaginal support simulating application via transvaginal and transabdominal approaches in a macaque model focusing on the impact on vaginal structure, function, and the host immune response. In 16 macaques, after laparotomy, the uterosacral ligaments and paravaginal attachments to pelvic side wall were completely transected (IACUC# 13081928)...
May 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28454911/biomechanical-and-morphological-properties-of-the-multiparous-ovine-vagina-and-effect-of-subsequent-pregnancy
#2
Rita Rynkevic, Pedro Martins, Lucie Hympanova, Henrique Almeida, Antonio A Fernandes, Jan Deprest
Pelvic floor soft tissues undergo changes during the pregnancy. However, the degree and nature of this process is not completely characterized. This study investigates the effect of subsequent pregnancy on biomechanical and structural properties of ovine vagina. Vaginal wall from virgin, pregnant (in their third pregnancy) and parous (one year after third vaginal delivery) Swifter sheep (n=5 each) was harvested. Samples for biomechanics and histology, were cut in longitudinal axis (proximal and distal regions)...
April 9, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28374826/ovine-multiparity-is-associated-with-diminished-vaginal-muscularis-increased-elastic-fibres-and-vaginal-wall-weakness-implication-for-pelvic-organ-prolapse
#3
Stuart Emmerson, Natharnia Young, Anna Rosamilia, Luke Parkinson, Sharon L Edwards, Aditya V Vashi, Miranda Davies-Tuck, Jacinta White, Kirstin Elgass, Camden Lo, John Arkwright, Jerome A Werkmeister, Caroline E Gargett
Pelvic Organ Prolapse (POP) is a major clinical burden affecting 25% of women, with vaginal delivery a major contributing factor. We hypothesised that increasing parity weakens the vagina by altering the extracellular matrix proteins and smooth muscle thereby leading to POP vulnerability. We used a modified POP-quantification (POP-Q) system and a novel pressure sensor to measure vaginal wall weakness in nulliparous, primiparous and multiparous ewes. These measurements were correlated with histological, biochemical and biomechanical properties of the ovine vagina...
April 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28294563/a-new-material-for-tissue-engineered-vagina-reconstruction-acellular-porcine-vagina-matrix
#4
Jing-Kun Zhang, Run-Xuan Du, Lin Zhang, Ya-Nan Li, Ming-Le Zhang, Shuo Zhao, Xiang-Hua Huang, Yan-Fang Xu
Acellular matrix materials have been widely used to repair various tissues and organs. According to the plastic principle, when a part of the body is lost, it should be replaced with a similar material. Therefore, the use of a homologous organ-specific acellular vaginal tissue in vagina reconstruction repair surgery may show good results. However, the acellular vagina matrix (AVM) form large vertebrates is difficult to isolate. In this study, we described a multistep method to prepare porcine AVM and evaluated the efficacy of acellularization...
March 10, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28252311/-sheep-as-an-experimental-model-in-the-reaserch-of%C3%A2-effects-of-pregnancy-delivery-and-surgical-procedures-on-the-pelvic-floor
#5
I Urbánková, L Hympánová, L Krofta
OBJECTIVE: A short literature review of ewe as an experimental model in research of effects of pregnancy, delivery and urogynecological surgical procedures on the pelvic floor. DESIGN: Literature overview. SETTING: Institute for the Care of Mother and Child, Third Faculty of Medicine, Prague. METHODS: This is an overview of recent literature on experiments using ewes as a model for biomechanical and morphological changes of the vagina induced by pregnancy, delivery and transvaginal graft implantation...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/26828789/exploring-biomechanical-methods-to-study-the-human-vaginal-wall
#6
Robert Eberhart, Cheng-Jen Chuong, Philippe Zimmern
AIMS: To critically review studies of the biomechanical properties of connective tissue in the normal and prolapsed human vaginal wall and to identify criteria that are suitable for in vivo measurements which could improve patient management. METHODS: This review covers past and current ex vivo and in vivo instrumentation and analytical methods related to the elastic and viscoelastic properties of vaginal wall connective tissues. RESULTS: Classical methods, including digital evaluation of the vagina, histological and biomechanical studies of fresh and frozen-thawed extracts, and biomechanical cadaveric tissue studies have important limitations and have yielded inconsistent results...
February 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/26382313/differential-effects-of-selective-estrogen-receptor-modulators-on-the-vagina-and-its-supportive-tissues
#7
Rui Liang, Katrina Knight, Alexis Nolfi, Steven Abramowitch, Pamela A Moalli
OBJECTIVE: Some selective estrogen receptor modulators (SERMs) have been associated with increased incidence of urinary incontinence and pelvic organ prolapse. This study explored the effects of five SERMs on the function and matrix components of the vagina and its supportive tissues. METHODS: Fifty-six rats were administered SERMs by oral gavage for 8 weeks (n = 8 for each SERM): raloxifene, tamoxifen, idoxifene, bazedoxifene at three different doses, and bazedoxifene with conjugated estrogens...
February 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/26348376/changes-in-pelvic-organ-prolapse-mesh-mechanical-properties-following-implantation-in-rats
#8
Daniela Ulrich, Sharon L Edwards, David L J Alexander, Anna Rosamilia, Jerome A Werkmeister, Caroline E Gargett, Vincent Letouzey
BACKGROUND: Pelvic organ prolapse (POP) is a multifactorial disease that manifests as the herniation of the pelvic organs into the vagina. Surgical methods for prolapse repair involve the use of a synthetic polypropylene mesh. The use of this mesh has led to significantly higher anatomical success rates compared with native tissue repairs, and therefore, despite recent warnings by the Food and Drug Administration regarding the use of vaginal mesh, the number of POP mesh surgeries has increased over the last few years...
February 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/25960708/cross-linked-xenogenic-collagen-implantation-in-the-sheep-model-for-vaginal-surgery
#9
Masayuki Endo, Iva Urbankova, Jaromir Vlacil, Siddarth Sengupta, Thomas Deprest, Bernd Klosterhalfen, Andrew Feola, Jan Deprest
The properties of meshes used in reconstructive surgery affect the host response and biomechanical characteristics of the grafted tissue. Whereas durable synthetics induce a chronic inflammation, biological grafts are usually considered as more biocompatible. The location of implantation is another determinant of the host response: the vagina is a different environment with specific function and anatomy. Herein, we evaluated a cross-linked acellular collagen matrix (ACM), pretreated by the anti-calcification procedure ADAPT® in a sheep model for vaginal surgery...
2015: Gynecological Surgery
https://www.readbyqxmd.com/read/25148261/regional-variation-in-tissue-composition-and-biomechanical-properties-of-postmenopausal-ovine-and-human-vagina
#10
Daniela Ulrich, Sharon L Edwards, Vincent Letouzey, Kai Su, Jacinta F White, Anna Rosamilia, Caroline E Gargett, Jerome A Werkmeister
OBJECTIVE: There are increasing numbers of reports describing human vaginal tissue composition in women with and without pelvic organ prolapse with conflicting results. The aim of this study was to compare ovine and human posterior vaginal tissue in terms of histological and biochemical tissue composition and to assess passive biomechanical properties of ovine vagina to further characterise this animal model for pelvic organ prolapse research. STUDY DESIGN: Vaginal tissue was collected from ovariectomised sheep (n = 6) and from postmenopausal women (n = 7) from the proximal, middle and distal thirds...
2014: PloS One
https://www.readbyqxmd.com/read/24709913/influence-of-reproductive-status-on-tissue-composition-and-biomechanical-properties-of-ovine-vagina
#11
Daniela Ulrich, Sharon L Edwards, Kai Su, Jacinta F White, John A M Ramshaw, Graham Jenkin, Jan Deprest, Anna Rosamilia, Jerome A Werkmeister, Caroline E Gargett
OBJECTIVE: To undertake a comprehensive analysis of the biochemical tissue composition and passive biomechanical properties of ovine vagina and relate this to the histo-architecture at different reproductive stages as part of the establishment of a large preclinical animal model for evaluating regenerative medicine approaches for surgical treatment of pelvic organ prolapse. METHODS: Vaginal tissue was collected from virgin (n = 3), parous (n = 6) and pregnant sheep (n = 6; mean gestation; 132 d; term = 145 d)...
2014: PloS One
https://www.readbyqxmd.com/read/24452620/biomechanics-of-the-rat-vagina-during-pregnancy-and-postpartum-a-3-dimensional-ultrasound-approach
#12
Andrew Feola, Masayuki Endo, Jan Deprest
INTRODUCTION AND HYPOTHESIS: The vagina and surrounding structures have been shown to remodel during pregnancy. Our objective was to characterize the biomechanical properties of the vagina in the rodent model in vivo utilizing three-dimensional (3D) ultrasound. METHODS: The vagina was visualized by ultrasound after distention by increasing pressures throughout pregnancy (15 and 18 days) and after vaginal delivery (7 and 30 days postpartum) of six longitudinally followed rodents...
July 2014: International Urogynecology Journal
https://www.readbyqxmd.com/read/24291809/comparison-of-polypropylene-mesh-and-porcine-derived-cross-linked-urinary-bladder-matrix-materials-implanted-in-the-rabbit-vagina-and-abdomen
#13
COMPARATIVE STUDY
Xuemei Fan, Yanzhou Wang, Yu Wang, Huicheng Xu
INTRODUCTION AND HYPOTHESES: Our aim was to compare histological and biomechanical effects of polypropylene (PP) mesh and porcine-derived, cross-linked urinary bladder matrix (cUBM) graft materials using a rabbit vaginal and abdominal model. METHODS: Forty rabbits were implanted with PP mesh (n = 20) or cUBM (n = 20) in the vagina and abdomen. Two grafts (PP or cUBM) of the same type were placed into each site, so each rabbit had four grafts. Grafts were harvested 12 weeks later and processed for histologic analysis and biomechanical testing...
May 2014: International Urogynecology Journal
https://www.readbyqxmd.com/read/24174572/estrogen-alters-remodeling-of-the-vaginal-wall-after-surgical-injury-in-guinea-pigs
#14
Sunil Balgobin, T Ignacio Montoya, Haolin Shi, Jesus F Acevedo, Patrick W Keller, Matthew Riegel, Clifford Y Wai, Ruth Ann Word
Loss of pelvic organ support (i.e., pelvic organ prolapse) is common in menopausal women. Surgical reconstruction of pelvic organ prolapse is plagued with high failure rates. The objective of this study was to determine the effects of estrogen on biomechanical properties, lysyl oxidase (LOX), collagen content, and histomorphology of the vagina with or without surgical injury. Nulliparous ovariectomized guinea pigs were treated systemically with either 50 μg/kg/day estradiol (E2,) or vehicle. After 2 wk, vaginal surgery was performed, and animals were treated with either beta-aminopropionitrile (BAPN, an irreversible LOX inhibitor), or vehicle to determine the role of LOX in recovery of the vaginal wall from injury with or without E2...
December 2013: Biology of Reproduction
https://www.readbyqxmd.com/read/23295833/biomechanical-properties-of-vaginal-tissue-in-women-with-pelvic-organ-prolapse
#15
Pedro Martins, Agnaldo Lopes Silva-Filho, Andrea Moura Rodrigues Maciel da Fonseca, Agostinho Santos, Liliana Santos, Teresa Mascarenhas, Renato M Natal Jorge, António J M Ferreira
BACKGROUND/AIMS: To compare biomechanical properties of vaginal tissues between women with and without pelvic organ prolapse (POP) and investigate factors that may influence these properties. METHODS: Forty patients submitted to POP surgery and 15 non-POP cadavers were evaluated. The tissue was excised from anterior and posterior middle third vagina. The biomechanical properties considered were stiffness (E) and maximum stress (S), and they were evaluated by means of uniaxial tension tests...
2013: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/23240803/graft-related-complications-and-biaxial-tensiometry-following-experimental-vaginal-implantation-of-flat-mesh-of-variable-dimensions
#16
COMPARATIVE STUDY
S Manodoro, M Endo, P Uvin, M Albersen, J Vláčil, A Engels, B Schmidt, D De Ridder, A Feola, J Deprest
OBJECTIVE: To compare the occurrence of graft-related complications (GRCs) and biomechanical properties of meshes implanted vaginally and abdominally. DESIGN: In vivo animal experiment. SETTING: Centre for Surgical Technologies, Medical Faculty, KU Leuven, Belgium. POPULATION: Twenty adult parous Texel ewes. METHODS: Sheep were implanted with Gynemesh M, a 28-g/m² polypropylene mesh reinforced with polyglecaprone fibres, under general anaesthesia...
January 2013: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/23240801/deterioration-in-biomechanical-properties-of-the-vagina-following-implantation-of-a-high-stiffness-prolapse-mesh
#17
COMPARATIVE STUDY
A Feola, S Abramowitch, Z Jallah, S Stein, W Barone, S Palcsey, P Moalli
OBJECTIVE: To define the impact of prolapse mesh on the biomechanical properties of the vagina by comparing the prototype Gynemesh PS (Ethicon) to two new-generation lower stiffness meshes, SmartMesh (Coloplast) and UltraPro (Ethicon). DESIGN: A study employing a nonhuman primate model. SETTING: University of Pittsburgh, PA, USA. POPULATION: Forty-five parous rhesus macaques. METHODS: Meshes were implanted via sacrocolpopexy after hysterectomy and compared with sham...
January 2013: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/23208004/changes-in-the-rheological-behavior-of-the-vagina-in-women-with-pelvic-organ-prolapse
#18
Andrew Feola, Robert Duerr, Pamela Moalli, Steven Abramowitch
INTRODUCTION AND HYPOTHESIS: Pelvic organ prolapse is a common condition impacting the quality of life of millions of women worldwide. Although vaginal estrogen is widely used in women with prolapse, little is known regarding estrogen's benefits on the biomechanical properties of vaginal tissue. Here, we aimed to examine the effect of prolapse on the biomechanical properties of the vagina and determine alterations in vaginal mechanics in the presence and absence of hormone therapy (HT)...
July 2013: International Urogynecology Journal
https://www.readbyqxmd.com/read/23185528/a-preclinical-evaluation-of-alternative-synthetic-biomaterials-for-fascial-defect-repair-using-a-rat-abdominal-hernia-model
#19
Daniela Ulrich, Sharon L Edwards, Jacinta F White, Tommy Supit, John A M Ramshaw, Camden Lo, Anna Rosamilia, Jerome A Werkmeister, Caroline E Gargett
INTRODUCTION: Fascial defects are a common problem in the abdominal wall and in the vagina leading to hernia or pelvic organ prolapse that requires mesh enhancement to reduce operation failure. However, the long-term outcome of synthetic mesh surgery may be unsatisfactory due to post-surgical complications. We hypothesized that mesh fabricated from alternative synthetic polymers may evoke a different tissue response, and provide more appropriate mechanical properties for hernia repair...
2012: PloS One
https://www.readbyqxmd.com/read/22527542/biomechanical-effects-of-polyglecaprone-fibers-in-a-polypropylene-mesh-after-abdominal-and-rectovaginal-implantation-in-a-rabbit
#20
COMPARATIVE STUDY
Yves Ozog, Edoardo Mazza, Dirk De Ridder, Jan Deprest
INTRODUCTION AND HYPOTHESIS: To investigate the biomechanical effects of polyglecaprone fibers in lightweight meshes implanted into the vaginal and abdominal wall of parous rabbits. METHODS: New Zealand White rabbits (n = 24) were implanted with polypropylene meshes (32 g/m(2)), with (Prolift plus M, n = 12) or without (Prolift minus M, n = 12) polyglecaprone fibers. Following implantation in the posterior vaginal and abdominal wall, local side effects were evaluated and explants underwent uniaxial tensiometry after 120 and 180 days...
October 2012: International Urogynecology Journal
keyword
keyword
19275
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"