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https://www.readbyqxmd.com/read/29344460/impact-of-integrated-teaching-sessions-for-comprehensive-learning-and-rational-pharmacotherapeutics-for-medical-undergraduates
#1
Sneha Ambwani, Bhavisha Vegada, Rimple Sidhu, Jaykaran Charan
Background: It is postulated that integrated teaching method may enhance retention of the knowledge and clinical applicability of the basic sciences as compared to the didactic method. Aim: The present study was undertaken to compare the integrated teaching method with the didactic method for the learning ability and clinical applicability of the basic sciences. Materials and Methods: The 2nd year MBBS students were divided into two groups randomly...
December 2017: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/29343286/diagnosis-and-management-of-transthyretin-familial-amyloid-polyneuropathy-in-japan-red-flag-symptom-clusters-and-treatment-algorithm
#2
REVIEW
Yoshiki Sekijima, Mitsuharu Ueda, Haruki Koike, Sonoko Misawa, Tomonori Ishii, Yukio Ando
Hereditary ATTR (ATTRm) amyloidosis (also called transthyretin-type familial amyloid polyneuropathy [ATTR-FAP]) is an autosomal-dominant, adult-onset, rare systemic disorder predominantly characterized by irreversible, progressive, and persistent peripheral nerve damage. TTR gene mutations (e.g. replacement of valine with methionine at position 30 [Val30Met (p.Val50Met)]) lead to destabilization and dissociation of TTR tetramers into variant TTR monomers, which form amyloid fibrils that deposit in peripheral nerves and various organs, giving rise to peripheral and autonomic neuropathy and several non-disease specific symptoms...
January 17, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29339724/granulocyte-colony-stimulating-factor-controls-neural-and-behavioral-plasticity-in-response-to-cocaine
#3
Erin S Calipari, Arthur Godino, Emily G Peck, Marine Salery, Nicholas L Mervosh, Joseph A Landry, Scott J Russo, Yasmin L Hurd, Eric J Nestler, Drew D Kiraly
Cocaine addiction is characterized by dysfunction in reward-related brain circuits, leading to maladaptive motivation to seek and take the drug. There are currently no clinically available pharmacotherapies to treat cocaine addiction. Through a broad screen of innate immune mediators, we identify granulocyte-colony stimulating factor (G-CSF) as a potent mediator of cocaine-induced adaptations. Here we report that G-CSF potentiates cocaine-induced increases in neural activity in the nucleus accumbens (NAc) and prefrontal cortex...
January 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29339063/evolution-of-intravitreal-therapy-for-retinal-diseases-from-cmv-to-cnv-the-lxxiv-edward-jackson-memorial-lecture
#4
Daniel F Martin
PURPOSE: To present the evolution of intravitreal therapy for retinal diseases and its impact on clinical practice. DESIGN: Retrospective literature review and personal perspective. METHODS: Retrospective literature review and personal perspective. RESULTS: Pharmacotherapeutic advances in retinal disease have been remarkable over the last 25 years. Almost all of the new drugs developed have required intravitreal administration to be highly effective, leading to an exponential increase in the annual number of intravitreal injections given...
January 12, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29319156/overview-of-the-european-medicines-agency-s-development-of-product-specific-bioequivalence-guidelines
#5
Jane O' Sullivan, Kevin Blake, Michael Berntgen, Tomas Salmonson, Jan Welink
The European Medicines Agency's (EMA) product-specific bioequivalence guidelines outline harmonized regulatory requirements for studies to demonstrate bioequivalence for products that may have particular needs due to their pharmacokinetics, in addition to those outlined in general guidance. As such they are potentially very useful to the pharmaceutical industry in the development of generic medicinal products and to regulatory authorities for harmonized decision-making. Since their introduction in 2013, EMA product-specific bioequivalence guidelines continue to increase in number, and as of June 2017, encompass a number of different pharmacotherapeutic groups and pharmaceutical forms...
December 5, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29297657/pharmacotherapeutic-management-of-pseudobulbar-affect
#6
Jack J Chen
This activity will update pharmacists and other healthcare professionals on current treatments for pseudobulbar affect (PBA). Points of discussion will focus on the off-label therapies traditionally used to treat PBA, the FDA-approved combination drug product with PBA as an indication, and managed care aspects of treating PBA.
December 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/29296801/pharmacotherapeutical-strategies-in-the-prevention-of-acute-vaso-occlusive-pain-in-sickle-cell-disease-a-systematic-review
#7
REVIEW
Joep W R Sins, David J Mager, Shyrin C A T Davis, Bart J Biemond, Karin Fijnvandraat
Sickle-cell disease (SCD) is characterized by frequent and painful vaso-occlusive crises (VOCs). Various treatments have been evaluated over the years. However, a clear overview is lacking. The objective of this study was to systematically review all pharmacotherapeutical strategies in the prevention of VOCs beyond hydroxyurea. We performed a systematic literature search (MEDLINE, Embase, CENTRAL). Eligible studies were controlled clinical trials evaluating pharmacotherapeutical interventions targeting the reduction of VOCs in patients with SCD...
August 22, 2017: Blood Advances
https://www.readbyqxmd.com/read/29285962/cellular-and-molecular-mechanisms-driving-neuropathic-pain-recent-advancements-and-challenges
#8
Valencia Fernandes, Dilip Sharma, Shivani Vaidya, Shantanu P A, Yun Guan, Kiran Kalia, Vinod Tiwari
Current pharmacotherapeutics for neuropathic pain offer only symptomatic relief without treating the underlying pathophysiology. Additionally, they are associated with various dose-limiting side effects. Pain research in the past few decades has revolved around the role of oxidative-nitrosative stress, protein kinases, glial cell activation, and inflammatory signaling cascades but has failed to produce specific and effective therapies. Areas Covered: This review focuses on recent advances in cellular and molecular mechanisms of neuropathic pain that may be translated into future therapies...
December 29, 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/29279716/fraxinus-a-plant-with-versatile-pharmacological-and-biological-activities
#9
REVIEW
Iqra Sarfraz, Azhar Rasul, Farhat Jabeen, Tahira Younis, Muhammad Kashif Zahoor, Muhammad Arshad, Muhammad Ali
Fraxinus, a member of the Oleaceae family, commonly known as ash tree is found in northeast Asia, north America, east and western France, China, northern areas of Pakistan, India, and Afghanistan. Chemical constituents of Fraxinus plant include various secoiridoids, phenylethanoids, flavonoids, coumarins, and lignans; therefore, it is considered as a plant with versatile biological and pharmacological activities. Its tremendous range of pharmacotherapeutic properties has been well documented including anticancer, anti-inflammatory, antioxidant, antimicrobial, and neuroprotective...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29278235/role-of-hormones-in-hypoactive-sexual-desire-disorder-and-current-treatment
#10
Ahmed AlAwlaqi, Houda Amor, Mohamed E Hammadeh
Over the decades, female sexual dysfunction (FSD) has grown to be an increasingly potential problem that complicates the quality of life among women. In the current review, FSD refers to recurrent and persistent problems with sexual orgasm, desire, or response. One of the most common subtypes of FSD that has evoked increased research interest in the scientific community is hyposexuality. Today, there is a consensus that hyposexuality is a multifactorial condition that manifests with reduced sexual desire resulting in significant interpersonal distress...
December 15, 2017: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/29233322/using-simplistic-simulations-to-enhance-learning-in-a-nephrology-pharmacotherapeutics-module
#11
Yen H Dang
BACKGROUND AND PURPOSE: The purpose of this study was to evaluate the effect of a simplistic simulation exercise in a nephrology module on pharmacy students' learning in a three-year concentrated curriculum. EDUCATIONAL ACTIVITY AND SETTING: Second year pharmacy students participated in a two-part simulation on electrolyte imbalances and dialysis in a nephrology pharmacotherapeutics module. Students completed a seven-item anonymous survey at the end of the simulation on a five-point Likert scale to examine the effect of the simulation and their attitudes to the exercise...
September 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29227643/structure-activity-relationship-studies-on-a-series-of-3%C3%AE-bis-4-fluorophenyl-methoxy-tropanes-and-3%C3%AE-bis-4-fluorophenyl-methylamino-tropanes-as-novel-atypical-dopamine-transporter-dat-inhibitors-for-the-treatment-of-cocaine-use-disorders
#12
Mu-Fa Zou, Jianjing Cao, Ara M Abramyan, Theresa Kopajtic, Claudio Zanettini, Daryl A Guthrie, Rana Rais, Barbara S Slusher, Lei Shi, Claus J Loland, Amy Hauck Newman
The development of medications to treat cocaine use disorders has thus far defied success, leaving this patient population without pharmacotherapeutic options. As the dopamine transporter (DAT) plays a prominent role in the reinforcing effects of cocaine that can lead to addiction, atypical DAT inhibitors have been developed that prevent cocaine from binding to DAT, but they themselves are not cocaine-like. Herein, a series of novel DAT inhibitors were synthesized, and based on its pharmacological profile, the lead compound 10a was evaluated in phase I metabolic stability studies in mouse liver microsomes and compared to cocaine in locomotor activity and drug discrimination paradigms in mice...
December 11, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29227274/study-of-pharmacometric-indexes-of-dosing-regimen-of-antihypoxant-okagerm-4
#13
V Lukyanchuk, D Kravets, D Litvinenko
In series of pharmacometrics research by determination of an optimum model of dosing is established that introduction of OKAGERM-4 in a dose of 96.8 mg/kg administered 40 minutes before the start of hypoxic damage realizes in maximum increase of estimated life expectancy of animals in hermetically sealed containers (65.57 min), ensuring a maximum effect of potential pharmacotherapeutic remedy - tartaric acid-based coordination compound of germanium with manganese. Thus, the results of pharmacometric research aimed to develop dosing regimen of OKAGERM-4 may be the base for future episodes of its pre-clinical study...
November 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29222923/co-administration-of-low-dose-naltrexone-and-bupropion-reduces-alcohol-drinking-in-alcohol-preferring-p-rats
#14
Emily R Nicholson, Julian E Dilley, Janice C Froehlich
BACKGROUND: This study examined whether combining naltrexone (NTX) with bupropion (BUP) is more effective in reducing alcohol drinking in alcohol-preferring (P) rats with a genetic predisposition toward high voluntary alcohol intake than is either drug alone. METHODS: Alcohol-experienced, adult, male, alcohol-preferring (P) rats were fed NTX alone in a dose of 10.0 mg/kg BW, BUP alone in a dose of 10.0 mg/kg BW, BUP alone in a dose of 20.0 mg/kg BW, NTX (10.0 mg/kg BW) + BUP (10...
December 9, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29222856/homocysteine-as-a-non-classical-risk-factor-for-atherosclerosis-in-relation-to-pharmacotherapy-of-type-2-diabetes-mellitus
#15
Magdalena Borowska, Marzena Dworacka, Hanna Winiarska, Ewa Krzyżagórska
AIMS: The aim of our study was to evaluate which of the pharmacotherapeutic methods that are frequently used to treat type 2 diabetes is associated with the most beneficial profile in relation to pro-atherogenic homocysteine levels. PATIENTS AND METHODS: We measured the serum homocysteine level in 182 patients with type 2 diabetes treated with metformin (89), treated with insulin in combination with metformin (31), receiving sulfonylureas (31) and treated conventionally with insulin (31)...
2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29217185/selenizing-astragalus-polysaccharide-attenuates-pcv2-replication-promotion-caused-by-oxidative-stress-through-autophagy-inhibition-via-pi3k-akt-activation
#16
Dandan Liu, Jing Xu, Gang Qian, Mohammed Hamid, Fang Gan, Xingxiang Chen, Kehe Huang
Our previous studies have shown that oxidative stress could promote the porcine circovirus type 2 (PCV2) replication, and astragalus polysaccharide (APS)/selenium could suppress PCV2 replication. However, whether selenizing astragalus polysaccharide (sAPS) provides protection against oxidative stress-induced PCV2 replication promotion and the mechanism involved remain unclear. The present study aimed to explore the mechanism of the PCV2 replication promotion induced by oxidative stress and a novel pharmacotherapeutic approach involving the regulation of autophagy of sAPS...
December 4, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29211140/pharmacotherapeutic-profile-of-users-and-expenditure-on-high-cost-drugs-in-s%C3%A3-o-leopoldo-rio-grande-do-sul-state-brazil-2014
#17
Mariani Sopelsa, Fabiane Raquel Motter, Nêmora Tregnago Barcellos, Heloísa Marquardt Leite, Vera Maria Vieira Paniz
OBJECTIVE: to describe the pharmacotherapeutic profile of users of the Specialized Program for Pharmaceutical Assistance, and to measure the expenditure on the most prevalent and the most expensive medications. METHODS: descriptive study conducted in São Leopoldo-RS, Brazil, with secondary data regarding information about requests accepted in 2014, through administrative proceedings; delivery notes of the State Health Department/RS were used to assess the costs...
October 2017: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/29209174/potential-mechanisms-underlying-inflammation-enhanced-aminoglycoside-induced-cochleotoxicity
#18
REVIEW
Meiyan Jiang, Farshid Taghizadeh, Peter S Steyger
Aminoglycoside antibiotics remain widely used for urgent clinical treatment of life-threatening infections, despite the well-recognized risk of permanent hearing loss, i.e., cochleotoxicity. Recent studies show that aminoglycoside-induced cochleotoxicity is exacerbated by bacteriogenic-induced inflammation. This implies that those with severe bacterial infections (that induce systemic inflammation), and are treated with bactericidal aminoglycosides are at greater risk of drug-induced hearing loss than previously recognized...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29209088/inhibitory-effects-of-curcumin-and-cyclocurcumin-in-1-methyl-4-phenylpyridinium-mpp-induced-neurotoxicity-in-differentiated-pc12-cells
#19
Sandeep Chakraborty, Artashes Karmenyan, Jin-Wu Tsai, Arthur Chiou
Development and progression of neurodegenerative diseases like Parkinson's disease (PD) involve multiple pathways. Thus, effective therapeutic treatments should intervene to address all these pathways simultaneously for greater success. Most of the current pharmacotherapeutic approaches just supplement striatal dopamine. Hence, natural extracts of plants with therapeutic potential have been explored. Curcuminoids belong to one such group of polyphenol which show immense therapeutic effects. Here, we have used intracellular reactive oxygen species (ROS) measurement, and two-photon fluorescence lifetime imaging microscopy (2P-FLIM) of cellular autofluorescent co-enzyme reduced nicotinamide adenine dinucleotide (NADH) to study the inhibitory effects of curcumin and cyclocurcumin in alleviating PD like neurotoxicity of 1-methyl-4-phenylpyridinium (MPP+) in neuronal growth factor (NGF) induced differentiated PC12 cells...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29206482/brain-circuits-and-neurochemical-systems-in-essential-tremor-insights-into-current-and-future-pharmacotherapeutic-approaches
#20
Sara M Schaefer, Ana Vives Rodriguez, Elan D Louis
There are few medications that are available for the treatment of essential tremor (ET) and they are only moderately effective. Areas covered: Data were obtained from a PubMed search. Original articles, review articles, and clinical guidelines were included. Two disease models for ET have been proposed: 1) the olivary model, which attributes ET to a pathological pacemaker in the inferior olivary nucleus, and 2) the cerebellar degeneration model, which postulates that ET originates in the cerebellum and could be related to deficient or abnormal Purkinje cell (PC) output...
December 5, 2017: Expert Review of Neurotherapeutics
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