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https://www.readbyqxmd.com/read/28724817/real-world-evidence-of-safety-profile-of-intravitreal-bevacizumab-avastin-in-an-indian-scenario
#1
Prashant Jain, Jay Sheth, Giridhar Anantharaman, Mahesh Gopalakrishnan
PURPOSE: The purpose of this study was to evaluate the safety profile of intravitreal bevacizumab (Avastin) as an off-label pharmacotherapeutic agent for various ocular conditions. METHODS: Retrospective analysis was carried out on 3806 injections of 1761 patients that were administered with intravitreal bevacizumab injection at a tertiary eye care center in India. The injections were administered on a pro re nata basis for various indications such as age-related macular degeneration (AMD), diabetic macular edema (DME), and retinal vein occlusion (RVO)...
July 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28724036/clinical-pharmacology-profile-of-care-in-hepatology-clinic
#2
Talita Rocha Passos, Fabiana Silva Santos, Maria Cleusa Martins, Vanusa Barbosa Pinto, Flair José Carrilho, Suzane Kioko Ono
Since 2010, the Clinical Gastroenterology and Hepatology Division of the Central Institute of Hospital das Clínicas of the University of São Paulo Medical School (HC-FMUSP, in the Portuguese acronym) has been developing specialized electives assistance activities in the Outpatient Specialty Clinic, Secondary Level, in São Paulo NGA-63 Várzea do Carmo. The objective of this study was to analyze the pharmacotherapeutic profile of patients. This is a cross-sectional and retrospective study in which patients were seen at the Hepatology sector and the results were submitted to descriptive statistics...
May 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28720921/a-team-based-assignment-to-integrate-basic-science-and-pharmacotherapeutic-principles-for-anticancer-agents
#3
Sonali Kurup, Paiboon Jungsuwadee, Prashant Sakharkar
Objective. To implement and evaluate an active-learning, team-based assignment centered on anticancer agents for the integration of basic science and pharmacotherapeutic principles. Methods. Student teams were assigned a specific anticancer agent and were expected to answer a series of questions on the written section of the assignment, followed by a presentation to the class. Each assignment was assessed using a grading rubric that was mapped to the 2013 CAPE educational outcomes. Student perceptions of the assignment were assessed using a short survey...
June 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28706397/assessment-of-sperm-deoxyribose-nucleic-acid-fragmentation-using-sperm-chromatin-dispersion-assay
#4
Harsha Pratap, Suma Yekappa Hottigoudar, Kubera Siddappa Nichanahalli, Parkash Chand
The integrity of sperm deoxyribose nucleic acid (DNA) is one of the determinants that ensure normal fertilization, implantation, pregnancy, and the generation of a healthy progeny. Assessment of sperm DNA fragmentation has gained importance as a tool to provide significant information regarding sperm quality, and it can independently predict sperm fertilizing potential. The sperm chromatin dispersion (SCD) assay is one of the available techniques to detect sperm DNA damage with results comparable to the gold standard - Sperm Chromatin Structure Assay...
April 2017: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/28700051/pharmacotherapeutic-follow-up-of-patients-with-chagas-disease-using-benznidazole-drug-related-problems-and-pharmaceutical-interventions
#5
João Paulo Ramalho Correia, Alanna Carla da Costa, Eduardo Arrais Rocha, Ana Rosa Pinto Quidute, Darlan da Silva Cândido, Ângela Maria de Souza Ponciano, Marta Maria de França Fonteles, Maria de Fátima Oliveira
INTRODUCTION: Benznidazole (BNZ) is a drug available for the etiological treatment of Chagas disease. However, this drug is toxic and has a limited effectiveness on the chronic phase of this disease, often leading to poor treatment adherence. METHODS: This is a descriptive and exploratory study conducted at the Pharmaceutical Care Service for Chagas disease patients of the Federal University of Ceará. Drug-related problems (DRPs) and pharmaceutical interventions (PIs) were classified according to the Second Consensus of Granada...
May 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28694148/intensity-dependence-of-auditory-evoked-potentials-in-primary-dysmenorrhea
#6
Bingren Zhang, You Xu, Wei He, Jiawei Wang, Hao Chai, Chanchan Shen, Qisha Zhu, Wei Wang
Some studies suggest that women with primary dysmenorrhea have distinct emotional or personality features. For example, they might exaggerate their responses to external stimuli, such as to intensity-increasing auditory stimuli. Fifteen women with primary dysmenorrhea and 15 healthy women were invited to undergo tests of the intensity dependence of auditory evoked potentials (IDAEP), the Functional and Emotional Measure of Dysmenorrhea, and the Plutchik-van Praag Depression Inventory. Study participants with dysmenorrhea displayed higher Functional and Emotional scale scores and stronger IDAEP...
July 7, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28683698/relationship-between-pharmacotherapy-complexity-and-patient-satisfaction-with-treatment-for-hepatitis-c
#7
Maria de Las Aguas Robustillo-Cortés, Carmen Victoria Almeida-González, Ramón Morillo-Verdugo
OBJECTIVE: To establish the relationship between the complexity of treatment for hepatitis C and patient satisfaction. Method: An observational, prospective, single-center study, which included HCV patients treated between October 2014 and February 2016. The primary endpoint was the assessment of satisfaction with treatment, measured by the HCV-ESTAR questionnaire, structured into two dimensions: clinical and lifestyle satisfaction, on a 0-60 score. A reliability analysis was performed...
July 1, 2017: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/28683317/whole-body-profiling-of-cancer-metastasis-with-single-cell-resolution
#8
Shimpei I Kubota, Kei Takahashi, Jun Nishida, Yasuyuki Morishita, Shogo Ehata, Kazuki Tainaka, Kohei Miyazono, Hiroki R Ueda
Stochastic and proliferative events initiated from a single cell can disrupt homeostatic balance and lead to fatal disease processes such as cancer metastasis. To overcome metastasis, it is necessary to detect and quantify sparsely distributed metastatic cells throughout the body at early stages. Here, we demonstrate that clear, unobstructed brain/body imaging cocktails and computational analysis (CUBIC)-based cancer (CUBIC-cancer) analysis with a refractive index (RI)-optimized protocol enables comprehensive cancer cell profiling of the whole body and organs...
July 5, 2017: Cell Reports
https://www.readbyqxmd.com/read/28680396/botulinum-neurotoxin-a-injected-ipsilaterally-or-contralaterally-into-the-striatum-in-the-rat-6-ohda-model-of-unilateral-parkinson-s-disease-differently-affects-behavior
#9
Veronica A Antipova, Carsten Holzmann, Oliver Schmitt, Andreas Wree, Alexander Hawlitschka
Parkinson's disease (PD) is one of the most frequent neurodegenerative disorders. The loss of dopaminergic neurons in the substantia nigra leads to a disinhibition of cholinergic interneurons in the striatum. Pharmacotherapeutical strategies of PD-related hypercholinism have numerous adverse side effects. We previously showed that ipsilateral intrastriatal injections of 1 ng in unilaterally 6-hydroxydopamine (6-OHDA)-lesioned rats inhibit apomorphine-induced rotation behavior significantly up to 6 months. In this study, we extended the behavioral testing of ipsilateral botulinum neurotoxin A (BoNT-A)-injection and additionally investigated the impact of intrastriatal BoNT-A-injections contralateral to the 6-OHDA-lesioned hemisphere on the basal ganglia circuity and motor functions...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28679296/pharmacological-targeting-of-spak-kinase-in-disorders-of-impaired-epithelial-transport
#10
Jinwei Zhang, Jason K Karimy, Eric Delpire, Kristopher T Kahle
The mammalian SPS1-related proline/alanine-rich serine-threonine kinase SPAK (STK39) modulates ion transport across and between epithelial cells in response to environmental stimuli such osmotic stress and inflammation. Research over the last decade has established a central role for SPAK in the regulation of ion and water transport in the distal nephron, colonic crypts, and pancreatic ducts, and has implicated deregulated SPAK signaling in NaCl-sensitive hypertension, ulcerative colitis and Crohn's disease, and cystic fibrosis...
July 12, 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28674291/comprehensive-analyses-of-molecules-with-altered-expression-in-the-brain-of-a-mouse-model-of-down-syndrome-for-identification-of-pharmacotherapeutic-targets
#11
Keiichi Ishihara
 Down syndrome, caused by the triplication of human chromosome 21, is the most frequent genetic cause of mental retardation. Mice with a segmental trisomy for mouse chromosome 16, which is orthologous to human chromosome 21, exhibit abnormalities similar to those in individuals with Down syndrome and therefore offer the opportunity for a genotype-phenotype correlation. In the current review, I present several mouse lines with trisomic regions of various lengths and discuss their usefulness for elucidating the mechanisms underlying Down syndrome-associated developmental cognitive disabilities...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28666925/ezh2-upregulation-correlates-with-tumor-invasiveness-proliferation-and-angiogenesis-in-human-pituitary-adenomas
#12
Bin Liu, Bo Pang, Qirui Wang, Shengji Yang, Taihong Gao, Qian Ding, Huajie Liu, Yihang Yang, Haitao Fan, Rui Zhang, Tao Xin, Guangming Xu, Qi Pang
Enhancer of zeste homolog 2 (EZH2) is a critical component of the polycomb repressive complex 2 (PRC2), which epigenetically represses genes involved in tumorigenesis and is highly expressed in tumors. However, no studies have investigated EZH2 expression and its clinical significance in human pituitary adenomas (PAs). Therefore, we examined the expression pattern of EZH2 in PAs and studied the correlations between protein expression and invasiveness, proliferation, angiogenesis, hormone functioning, and some other factors...
June 27, 2017: Human Pathology
https://www.readbyqxmd.com/read/28654165/using-personalized-medicine-in-the-management-of-diabetes-mellitus
#13
Nina Elk, Otito F Iwuchukwu
Diabetes mellitus is a worldwide problem of immense pharmacoeconomic burden. The multifactorial and complex nature of the disease lends itself to personalized pharmacotherapeutic approaches to treatment. Variability in individual risk and subsequent development of diabetes have been reported, in addition to differences in response to the many oral glucose lowering therapies currently available for diabetes pharmacotherapy. Pharmacogenomic studies have attempted to uncover the heritable components of individual variability in risk susceptibility and response to pharmacotherapy...
June 27, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28650915/the-brainstem-network-controlling-blood-pressure-an-important-role-for-pressor-sites-in-the-caudal-medulla-and-cervical-spinal-cord
#14
Michael G Z Ghali
: Although medullary control of blood pressure (BP) has been extensively studied, the contribution of critical regions, such as pressor sites in the caudal medulla and upper cervical spinal cord and the lateral tegmental field, remains controversial and underappreciated. A series of pressor sites caudal to the caudal ventrolateral medulla (CVLM), including the caudal pressor area (CPA) and medullocervical pressor area, play an important role in control of BP. Activation and inhibition of these sites elicits pressor and depressor responses, respectively...
June 24, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28641540/metallothionein-is-a-potential-therapeutic-strategy-for-amyotrophic-lateral-sclerosis
#15
Shin-Ichi Ono
Lou Gehrig's disease, a synonym of amyotrophic lateral sclerosis, is an adult-onset lethal neurodegenerative disorder. Irrespective of extensive efforts to elucidate the pathogenesis of the disease and searches for therapies, no favorable pharmacotherapeutic strategies have yet to be proposed. In a popular rodent model of ALS, G93A SOD1 mice, intracellular copper conditions were geared toward copper accumulation inside cells, resulting in an acceleration of oxidative stress and apoptotic process. Disruption of intracellular copper homeostasis was common to transgenic mice expressing human mutant SOD1s...
June 22, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28637234/a-baseline-assessment-by-healthcare-professionals-of-dutch-pharmacotherapeutic-care-for-the-elderly-with-polypharmacy
#16
Lutien Bakker, Peter F Kemper, Cordula Wagner, Gepke O Delwel, Martine C de Bruijne
Polypharmacy is common in the elderly population and is associated with an increased risk of adverse drug events. To diminish this risk, the guideline 'Polypharmacy in the Elderly' has been developed in 2012. This study examines, to what extent Dutch pharmacotherapeutic practice amongst elderly with polypharmacy mirrors the best practice described in this guideline and which barriers threaten it. An observational study was conducted in 2013/14 using a questionnaire distributed amongst Dutch healthcare professionals and elderly patients with polypharmacy...
June 14, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28631690/-medically-induced-rhinitis
#17
E V Nosulya
This paper summarizes the currently accepted concepts of the pathogenetic mechanisms underlying the morphological and functional changes in intranasal mucosa of the patients having a long history of the application of the long-acting topical vasoconstrictor agents. The author presents the data illustrating the effectiveness of various methods for the pharmacotherapeutic treatment of medically-induced rhinitis.
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28624642/drugsemantics-a-corpus-for-named-entity-recognition-in-spanish-summaries-of-product-characteristics
#18
Isabel Moreno, Ester Boldrini, Paloma Moreda, M Teresa Romá-Ferri
For the healthcare sector, it is critical to exploit the vast amount of textual health-related information. Nevertheless, healthcare providers have difficulties to benefit from such quantity of data during pharmacotherapeutic care. The problem is that such information is stored in different sources and their consultation time is limited. In this context, Natural Language Processing techniques can be applied to efficiently transform textual data into structured information so that it could be used in critical healthcare applications, being of help for physicians in their daily workload, such as: decision support systems, cohort identification, patient management, etc...
June 14, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28617389/-nosospecific-anxiety-and-a-spectrum-of-anxiolytic-activity-of-psychotropic-drugs
#19
V L Kozlovskii, O S Ronzhina
The article discusses the pathogenetic mechanisms of anxiety in different psychiatric disorders. The influence of anxiety on the course, pharmacotherapeutic treatment with respect to the pathogenesis and the possible neurochemical imbalance in the definite type of anxiety are discussed. An anti-anxiety effect in the action of psychotropic drugs is described. It is proposed that neurochemical disturbances are not the same with the various types of anxiety, which requires using drugs from various groups to achieve treatment of the symptom on the pathogenetic level...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28615780/converging-neurobiological-evidence-in-primary-polydipsia-resembling-obsessive-compulsive-disorder
#20
Karthick Subramanian, Tess Maria Rajan, Vikas Menon, Ravi Philip Rajkumar
Compulsive water drinking can have phenomenological and pharmacotherapeutic similarities with obsessive-compulsive disorder (OCD). Substantiating neurobiological evidence is lacking for such an association. We report a patient who was referred with a diagnosis of primary polydipsia with no signs of organic pathology in structural neuroimaging. However, positron emission tomography revealed basal ganglia hypometabolism indicating that primary polydipsia with compulsive water drinking is neurobiologically related to OCD...
May 2017: Indian Journal of Psychological Medicine
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