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https://www.readbyqxmd.com/read/28436179/monogenic-diabetes-prevalence-among-polish-children-summary-of-11%C3%A2-years-long-nationwide-genetic-screening-program
#1
Beata Małachowska, Maciej Borowiec, Karolina Antosik, Arkadiusz Michalak, Anna Baranowska-Jaźwiecka, Grażyna Deja, Przemysława Jarosz-Chobot, Agnieszka Brandt, Małgorzata Myśliwiec, Małgorzata Stelmach, Joanna Nazim, Jadwiga Peczyńska, Barbara Głowińska-Olszewska, Anita Horodnicka-Józwa, Mieczysław Walczak, Maciej T Małecki, Agnieszka Zmysłowska, Agnieszka Szadkowska, Wojciech Fendler, Wojciech Młynarski
BACKGROUND: Estimated monogenic diabetes (MD) prevalence increases as screening programs proceeds. OBJECTIVE: To estimate prevalence of MD among Polish children. SUBJECTS: Patients and their family members suspected of suffering from MD (defined as causative mutation in one of the Maturity Onset Diabetes of the Young or permanent neonatal diabetes mellitus genes) were recruited between January 2005 and December 2015. METHODS: Nationwide prevalence was estimated based on data from 6 administrative provinces (out of 16 in Poland) with high referral rates of patients (>10 per 100 000 children)...
April 24, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28430984/adjunctive-use-of-anticoagulants-at-the-time-of-percutaneous-coronary-intervention-in-patients-with-an-acute-coronary-syndrome-treated-with-fondaparinux-a-multinational-retrospective-review
#2
Jill E Abell, Shiona M Laing, Tara C Barker, Elliott C Norry, Kathryn Starzyk, Shaun G Goodman, Mikael Dellborg, P Gabriel Steg, Robert P Giugliano
Aim: This retrospective chart review was designed to evaluate physician adherence to the prescribing information for fondaparinux regarding adjunctive anticoagulant use during percutaneous coronary intervention (PCI) in patients with an acute coronary syndrome (ACS). Methods and Results: Medical record abstractors at each site obtained information regarding the use of fondaparinux and adjunctive anticoagulants during PCI. Physician adherence to fondaparinux prescribing information regarding the administration of an adjunctive anticoagulant during PCI was estimated using generalized estimating equations...
April 18, 2017: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/28427445/parasites-pathogens-and-commensals-in-the-low-impact-non-native-amphipod-host-gammarus-roeselii
#3
Jamie Bojko, Karolina Bącela-Spychalska, Paul D Stebbing, Alison M Dunn, Michał Grabowski, Michał Rachalewski, Grant D Stentiford
BACKGROUND: Whilst vastly understudied, pathogens of non-native species (NNS) are increasingly recognised as important threats to native wildlife. This study builds upon recent recommendations for improved screening for pathogens in NNS by focusing on populations of Gammarus roeselii in Chojna, north-western Poland. At this location, and in other parts of continental Europe, G. roeselii is considered a well-established and relatively 'low-impact' invader, with little understanding about its underlying pathogen profile and even less on potential spill-over of these pathogens to native species...
April 20, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28399191/association-between-uridin-diphosphate-glucuronosylotransferase-1a1-ugt1a1-gene-polymorphism-and-neonatal-hyperbilirubinemia
#4
Katarzyna Mazur-Kominek, Tomasz Romanowski, Krzysztof Bielawski, Bogumiła Kiełbratowska, Krzysztof Preis, Iwona Domżalska-Popadiuk, Magdalena Słomińska-Frączek, Katarzyna Sznurkowska, Joanna Renke, Katarzyna Plata-Nazar, Karolina Śledzińska, Grażyna Sikorska-Wiśniewska, Magdalena Góra-Gębka, Anna Liberek
OBJECTIVE: To assess the prevalence of UGT1A1*28 and UGT1A1*60 polymorphisms of UGT1A1 gene and their association with hyperbilirubinemia. STUDY DESIGN: The study was performed at a single centre - at the Department of Obstetrics of the Medical University of Gdansk in Poland. DNA was isolated from Guthrie cards of 171 infants. Only full term newborns (gestational age 38-42 weeks) were included in the study. Fluorescent molecular probes were used for UGT1A1 promoter variation analysis...
April 12, 2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/28397205/assessment-of-the-implementation-of-the-infectious-diseases-screening-programmes-among-pregnant-women-in-the-lesser-poland-region-and-comparison-with-similar-programmes-conducted-in-other-european-union-countries
#5
Małgorzata Radoń-Pokracka, Maciej Piasecki, Alicja Lachowska, Sebastian Baczkowski, Joanna Spaczyńska, Magdalena Górecka, Magdalena Nowak, Hubert Huras
OBJECTIVES: The aim of the study was to assess the level of implementation of recommendations of the Ministry of Health regarding infectious disease screening during pregnancy. MATERIAL AND METHODS: The study included 477 patients who were admitted to the delivery room between December 2015 and February 2016. Data on screening test results were collected based on medical records covering the period before the admission. RESULTS: The Human Immunodeficiency Virus (HIV) screening was conducted in 410 (86%)...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28381370/an-assessment-of-the-footprint-and-carrying-capacity-of-oil-and-gas-well-sites-the-implications-for-limiting-hydrocarbon-reserves
#6
S A Clancy, F Worrall, R J Davies, J G Gluyas
We estimate the likely physical footprint of well pads if shale gas or oil developments were to go forward in Europe and used these estimates to understand their impact upon existing infrastructure (e.g. roads, buildings), the carrying capacity of the environment, and how the proportion of extractable resources maybe limited. Using visual imagery, we calculate the average conventional well site footprints to be 10,800m(2) in the UK, 44,600m(2) in The Netherlands and 3000m(2) in Poland. The average area per well is 541m(2)/well in the UK, 6370m(2)/well in The Netherlands, and 2870m(2)/well in Poland...
March 30, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28379445/optimizing-use-of-girdled-ash-trees-for-management-of-low-density-emerald-ash-borer-coleoptera-buprestidae-populations
#7
Nathan W Siegert, Deborah G McCullough, Therese M Poland, Robert L Heyd
Effective survey methods to detect and monitor recently established, low-density infestations of emerald ash borer, Agrilus planipennis Fairmaire (Coleoptera: Buprestidae), remain a high priority because they provide land managers and property owners with time to implement tactics to slow emerald ash borer population growth and the progression of ash mortality. We evaluated options for using girdled ash (Fraxinus spp.) trees for emerald ash borer detection and management in a low-density infestation in a forested area with abundant green ash (F...
March 30, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28378991/assessment-of-antibiotic-susceptibility-of-legionella-pneumophila-isolated-from-water-systems-in-poland
#8
Agnieszka Sikora, Iwona Gładysz, Maria Kozioł-Montewka, Małgorzata Wójtowicz-Bobin, Tomasz Stańczak, Renata Matuszewska, Bożena Krogulska
INTRODUCTION AND OBJECTIVE: Several studies have reported therapy failures in patients with legionnaires'disease; however, antimicrobial resistance of clinical and environmental isolates of Legionella spp. has not yet been documented. Routine susceptibility testing of Legionella spp. is not recommended because of difficulties in determining standard minimal inhibitory concentration values. The purpose of this study was to analyze the antimicrobial susceptibility of Legionella pneumophila...
March 21, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28378974/level-of-contamination-with-mycobiota-and-contents-of-mycotoxins-from-the-group-of-trichothecenes-in-grain-of-wheat-oats-barley-rye-and-triticale-harvested-in-poland-in-2006-2008
#9
Kinga Stuper-Szablewska, Juliusz Perkowski
INTRODUCTION AND OBJECTIVE: The risk of cereal exposure to microbial contamination is high and possible at any time, starting from the period of plant vegetation, through harvest, up to the processing, storage and transport of the final product. Contents of mycotoxins in grain are inseparably connected with the presence of fungal biomass, the presence of which may indicate the occurrence of a fungus, and indirectly also products of its metabolism. MATERIALS AND METHOD: Analyses were conducted on 378 grain samples of wheat, triticale, barley, rye and oats collected from grain silos located at grain purchase stations and at mills in Poland in 2006, 2007 and 2008...
March 1, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28376348/cadmium-in-edible-plants-from-silesia-poland-and-its-implications-for-health-risk-in-populations
#10
Grzegorz Dziubanek, Renata Baranowska, Małgorzata Ćwieląg-Drabek, Anna Spychała, Agata Piekut, Monika Rusin, Ilona Hajok
The health risk associated with cadmium exposure through consumption of edible plants cultivated in different parts of the Silesia administration area inhabitants has been estimated. The impact of the arable soils acidity on the BCF (bioconcentration factor) has been also analyzed. The concentration of cadmium in arable soils and in 118 samples of vegetables - carrots, beets, potato, celery (tuber), parsley (root) were determined. The cadmium content in examined soil samples were in the range from >0.5-68...
April 1, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28366843/risk-assessment-related-to-biogenic-amines-occurrence-in-ready-to-eat-baby-foods
#11
Anna Czajkowska-Mysłek, Joanna Leszczyńska
Potential adverse reactions among infants and young children could appear after consumption of food containing small amounts of bioactive amines. This study presents the first assessment of biogenic amines occurrence in ready-to-eat vegetable without/with fish, meat and fruit baby products intended for the youngest consumers. The biogenic amine profiles and quantities of 6 amines were evaluated in 68 commercial baby foods produced by 10 leading manufacturers available in Poland, using HPLC-APCI-MS method. The total amine contents in analyzed products were obtained in the range of 1283-101421 ng/g...
March 30, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28362025/the-effect-of-neighboring-districts-on-body-height-of-polish-conscripts
#12
Aleksandra Gomula, Slawomir Koziel, Detlef Groth, Tadeusz Bielicki
The aim of the study was to investigate the correlation of heights of conscripts living in neighboring districts in Poland. The study used 10% of a nationally representative sample of 26,178 males 18.5-19.5 years old examined during the National survey of Polish conscripts conducted in 2001. The sample represented all regions and social strata of the country and included 354 different districts within 16 voivodships (provinces). Analyses were performed with the R statistical software. A small but significant correlation (0...
February 23, 2017: Anthropologischer Anzeiger; Bericht über die Biologisch-anthropologische Literatur
https://www.readbyqxmd.com/read/28349704/lc-esi-ms-ms-profiling-of-phenolics-in-the-leaves-of-eleutherococcus-senticosus-cultivated-in-the-west-europe-and-anti-hyaluronidase-and-anti-acetylcholinestarase-activities
#13
Rafał Kuźniewski, Daniel Załuski, Marta Olech, Piotr Banaszczak, Renata Nowak
Neither secondary metabolites of the spring leaves nor the autumn leaves of Eleutherococcus senticosus species cultivated in Poland, or the bioactivity are known. The richest in polyphenols was the autumn leaves (171.1 mg/g DE), while in flavonoids the spring leaves (107.9 mg/g DE). Using LC-ESI-MS/MS, protocatechuic acid has been identified as the most abundant compound in the spring and autumn leaves (200 and 70 μg/g DE, respectively). Amongst flavonoids, naringenin 7-O-glucoside occurred in the largest amount (20 and 10 mg/g DE in the spring and autumn leaves, respectively)...
March 28, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28345249/a-multinational-drug-utilisation-study-to-investigate-the-use-of-dexmedetomidine-dexdor%C3%A2-in-clinical-practice-in-the-eu
#14
M Weatherall, R Aantaa, G Conti, C J Garratt, P Pohjanjousi, M A Lewis, N Moore, S Perez-Gutthann
AIMS: Dexmedetomidine (dexdor®) is approved in the EU for sedation of adults in the ICU. This observational, retrospective study was requested by the European Medicines Agency to investigate dexmedetomidine use in clinical practice, with particular focus on off-label use including the paediatric population. METHODS: Study countries and sites were chosen from those with highest dexmedetomidine use, based on sales. Site selection (blind) was conducted by a multi-specialist, independent group...
March 27, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28327906/european-cancer-mortality-predictions-for-the-year-2017-with-focus-on-lung-cancer
#15
M Malvezzi, G Carioli, P Bertuccio, P Boffetta, F Levi, C La Vecchia, E Negri
Background: We predicted cancer mortality figures in the European Union (EU) for the year 2017 using most recent available data, with a focus on lung cancer. Materials and methods: We retrieved cancer death certification data and population figures from the World Health Organisation and Eurostat databases. Age-standardized (world standard population) rates were computed for France, Germany, Italy, Poland, Spain, the UK and the EU overall in 1970-2012. We obtained estimates for 2017 by implementing a joinpoint regression model...
February 21, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28324853/discursive-junctions-in-flood-risk-governance-a-comparative-understanding-in-six-european-countries
#16
Maria Kaufmann, Mark Wiering
Flood risks are managed differently across Europe. While a number of research studies aim to understand these differences, they tend to pay little attention to the social constructionist aspects of flood risk governance, i.e. the meaning that societies give to flood risk and governance. This paper aims to address this gap by understanding differences in flood risk management approaches (FRMA) from a discursive-institutional perspective. Based on this perspective, an analytical framework was developed to systematically analyse and compare discourses pertaining to flood risk and its governance in six European member states (England (the United Kingdom), Flanders (Belgium), France, the Netherlands, Poland and Sweden)...
March 18, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28318072/lifetime-risk-of-mortality-due-to-different-levels-of-alcohol-consumption-in-seven-european-countries-implications-for-low-risk-drinking-guidelines
#17
Kevin D Shield, Gerrit Gmel, Gerhard Gmel, Pia Mäkelä, Charlotte Probst, Robin Room, Jürgen Rehm
BACKGROUND AND AIMS: Low-risk alcohol drinking guidelines require a scientific basis that extends beyond individual or group judgements of risk. Lifetime mortality risks, judged against established thresholds for acceptable risk, may provide such a basis for guidelines. Therefore, the aim of this study was to estimate alcohol mortality risks for seven European countries based on different average daily alcohol consumption amounts. METHODS: The maximum acceptable voluntary premature mortality risk was determined to be 1 in 1,000, with sensitivity analyses of 1 in 100...
March 20, 2017: Addiction
https://www.readbyqxmd.com/read/28316794/periodontitis-as-a-possible-early-sign-of-diabetes-mellitus
#18
Wijnand J Teeuw, Madeline X F Kosho, Dennis C W Poland, Victor E A Gerdes, Bruno G Loos
OBJECTIVE: The early diagnosis of (pre)diabetes mellitus is essential for the prevention of diabetes complications. It has been suggested that gum disease (periodontitis) might be an early complication of diabetes and may be a useful risk indicator for diabetes screening. Therefore, a dental office could be a good location for screening for (pre)diabetes in patients with periodontitis using a validated glycated hemoglobin (HbA1c) dry spot analysis. RESEARCH DESIGN AND METHODS: A total of 313 individuals from a university dental clinic participated...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28303700/evaluation-of-dairy-products-available-on-the-polish-market-in-the-context-of-nutrient-profiles-clear-arguments-for-reformulation-of-foodstuffs
#19
Regina Wierzejska, Magdalena Siuba-Strzelińska, Mirosław Jarosz
Background: Dairy products, which are one of the main groups of products in the diet, are expected to have high nutritional value. The development of food technology often involves changing the nutritional parameters of foodstuffs. Objective: The aim of this study was to determine the nutritional value of dairy products, in the context of nutrient profiles. Material and Methods: The tested products included yoghurts, yoghurt drinks, kefir, cream cheeses and milk desserts available on the Polish market, basing on the information from unit product packaging...
2017: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/28303438/using-health-technology-assessment-to-assess-the-value-of-new-medicines-results-of-a-systematic-review-and-expert-consultation-across-eight-european-countries
#20
Aris Angelis, Ansgar Lange, Panos Kanavos
BACKGROUND: Although health technology assessment (HTA) systems base their decision making process either on economic evaluations or comparative clinical benefit assessment, a central aim of recent approaches to value measurement, including value based assessment and pricing, points towards the incorporation of supplementary evidence and criteria that capture additional dimensions of value. OBJECTIVE: To study the practices, processes and policies of value-assessment for new medicines across eight European countries and the role of HTA beyond economic evaluation and clinical benefit assessment...
March 16, 2017: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
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