Tyler C Gripshover, Banrida Wahlang, Kimberly Z Head, Jianzhu Luo, Oluwanifemi E Bolatimi, Melissa L Smith, Eric C Rouchka, Julia H Chariker, Jason Xu, Lu Cai, Timothy D Cummins, Michael L Merchant, Hao Zheng, Maiying Kong, Matthew C Cave
BACKGROUND: Environmental pollutants, including polychlorinated biphenyls (PCBs) have been implicated in the pathogenesis of liver disease. Our group recently demonstrated that PCB126 promoted steatosis, hepatomegaly, and modulated intermediary metabolism in a rodent model of alcohol-associated liver disease (ALD). OBJECTIVE: To better understand how PCB126 promoted ALD in our previous model, the current study adopts multiple omics approaches to elucidate potential mechanistic hypotheses...
April 2024: Environmental Health Perspectives