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https://www.readbyqxmd.com/read/28301843/specialty-based-variation-in-applying-maternal-fetal-surgery-trial-evidence
#1
Ryan M Antiel, Alan W Flake, Mark P Johnson, Nahla Khalek, Natalie E Rintoul, John D Lantos, Farr A Curlin, Jon C Tilburt, Chris Feudtner
INTRODUCTION: The Management of Myelomeningocele Study (MOMS) compared prenatal with postnatal surgery for fetal myelomeningocele (MMC). We sought to understand how subspecialists interpreted the trial results and whether their practice has changed. MATERIALS AND METHODS: Cross-sectional, mailed survey of 1,200 randomly selected maternal-fetal medicine (MFM) physicians, neonatologists, and pediatric surgeons. RESULTS: Of 1,176 eligible physicians, 670 (57%) responded...
March 17, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28288343/cleaning-of-contaminated-mfm-probes-using-a-bopp-film-and-external-magnetic-field
#2
Chao Zhang, Jinyun Liu, Qingling Meng, Wenxiao Zhang, Ying Wang, Dayou Li, Zuobin Wang
When magnetic samples are tested with a magnetic force microscope (MFM), the probe tip can inevitably be contaminated and magnetic particles are often adhered to the tip surface. The probe with magnetic contamination will seriously affect the quality of morphological and magnetic imaging. In the work, a method for the cleaning of contaminated magnetic probe tips was developed by the use of a biaxially-oriented polypropylene (BOPP) film together with an external magnet field in an MFM system. In the experiments, an MFM system was used for manipulating the tip to push into the BOPP film with a depth of 50-100nm under a magnetic field and hold for 5s, and the relationships between loading forces and separating forces were studied...
February 24, 2017: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/28280097/tailoring-porosity-and-rotational-dynamics-in-a-series-of-octacarboxylate-metal-organic-frameworks
#3
Florian Moreau, Daniil I Kolokolov, Alexander G Stepanov, Timothy L Easun, Anne Dailly, William Lewis, Alexander J Blake, Harriott Nowell, Matthew J Lennox, Elena Besley, Sihai Yang, Martin Schröder
Modulation and precise control of porosity of metal-organic frameworks (MOFs) is of critical importance to their materials function. Here we report modulation of porosity for a series of isoreticular octacarboxylate MOFs, denoted MFM-180 to MFM-185, via a strategy of selective elongation of metal-organic cages. Owing to the high ligand connectivity, these MOFs do not show interpenetration, and are robust structures that have permanent porosity. Interestingly, activated MFM-185a shows a high Brunauer-Emmett-Teller (BET) surface area of 4,734 m(2) g(-1) for an octacarboxylate MOF...
March 9, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28269794/myofibrillar-myopathies-new-perspectives-from-animal-models-to-potential-therapeutic-approaches
#4
Sabrina Batonnet-Pichon, Anthony Behin, Eva Cabet, Florence Delort, Patrick Vicart, Alain Lilienbaum
Myofibrillar myopathies (MFMs) are muscular disorders involving proteins that play a role in the structure, maintenance processes and protein quality control mechanisms closely related to the Z-disc in the muscular fibers. MFMs share common histological characteristics including progressive disorganization of the interfibrillar network and protein aggregation. Currently no treatment is available. In this review, we describe first clinical symptoms associated with mutations of the six genes (DES, CRYAB, MYOT, ZASP, FLNC and BAG3) primary involved in MFM and defining the origin of this pathology...
2017: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/28247926/non-invasive-determination-of-hv-interval-using-magnetocardiography
#5
Sengottuvel Senthilnathan, Raja J Selvaraj, Rajesh Patel, Santhosh Satheesh, Gireesan Katholil, Madhukar P Janawadkar, Thimmakudy S Radhakrishnan
BACKGROUND: The HV interval is an important index of atrio-ventricular conduction, but at present can be reliably measured only during an invasive electrophysiology (EP) study. Magnetocardiography (MCG) is a non-invasive measurement of weak magnetic fields generated by the heart. We compared HV interval non-invasively assessed using MCG with the corresponding values measured directly in an EP study. METHODS: MCG was measured using a 37 channel system inside a magnetically shielded room in patients who had previously undergone an EP study...
March 1, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28222643/reliability-of-home-based-motor-function-measure-in-hereditary-neuromuscular-diseases
#6
Xiomara Ruiz-Cortes, Fernando Ortiz-Corredor, Camilo Mendoza-Pulido
Objective To evaluate the reliability of the motor function measure (MFM) scale in the assessment of disease severity and progression when administered at home and clinic and assess its correlation with the Paediatric Outcomes Data Collection Instrument (PODCI). Methods In this prospective study, two assessors rated children with hereditary neuromuscular diseases (HNMDs) using the MFM at the clinic and then 2 weeks later at the patients' home. Intraclass correlation coefficient (ICC) was calculated for the reliability of the MFM and its domains...
February 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28194014/modulating-supramolecular-binding-of-carbon-dioxide-in-a-redox-active-porous-metal-organic-framework
#7
Zhenzhong Lu, Harry G W Godfrey, Ivan da Silva, Yongqiang Cheng, Mathew Savage, Floriana Tuna, Eric J L McInnes, Simon J Teat, Kevin J Gagnon, Mark D Frogley, Pascal Manuel, Svemir Rudić, Anibal J Ramirez-Cuesta, Timothy L Easun, Sihai Yang, Martin Schröder
Hydrogen bonds dominate many chemical and biological processes, and chemical modification enables control and modulation of host-guest systems. Here we report a targeted modification of hydrogen bonding and its effect on guest binding in redox-active materials. MFM-300(V(III)) {[V(III)2(OH)2(L)], LH4=biphenyl-3,3',5,5'-tetracarboxylic acid} can be oxidized to isostructural MFM-300(V(IV)), [V(IV)2O2(L)], in which deprotonation of the bridging hydroxyl groups occurs. MFM-300(V(III)) shows the second highest CO2 uptake capacity in metal-organic framework materials at 298 K and 1 bar (6...
February 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/28179932/root-canal-anatomy-and-morphology-of-mandibular-first-molars-in-a-selected-iranian-population-an-in-vitro-study
#8
Nahid Mohammadzadeh Akhlaghi, Zohreh Khalilak, Mehdi Vatanpour, Saman Mohammadi, Sakineh Pirmoradi, Mahta Fazlyab, Kamran Safavi
INTRODUCTION: The aim of this study was to evaluate root canal anatomy of mandibular first molars (MFM) in a selected Iranian Population using clearing technique. METHODS AND MATERIALS: A total of 150 extracted MFMs were cleared. The root canal morphology (including the root numbers and root length) and the anatomy of the root canal system (including is the number and type of canals based on Vertucci's classification, canal curvature according to Schneider's method and the presence of isthmus) was evaluated using the buccolingual and mesiodistal parallel x-rays and stereomicroscope...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/28176793/unravelling-exceptional-acetylene-and-carbon-dioxide-adsorption-within-a-tetra-amide-functionalized-metal-organic-framework
#9
Florian Moreau, Ivan da Silva, Nada H Al Smail, Timothy L Easun, Mathew Savage, Harry G W Godfrey, Stewart F Parker, Pascal Manuel, Sihai Yang, Martin Schröder
Understanding the mechanism of gas-sorbent interactions is of fundamental importance for the design of improved gas storage materials. Here we report the binding domains of carbon dioxide and acetylene in a tetra-amide functionalized metal-organic framework, MFM-188, at crystallographic resolution. Although exhibiting moderate porosity, desolvated MFM-188a exhibits exceptionally high carbon dioxide and acetylene adsorption uptakes with the latter (232 cm(3) g(-1) at 295 K and 1 bar) being the highest value observed for porous solids under these conditions to the best of our knowledge...
February 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/28170117/prevention-of-preterm-birth-with-pessary-in-twins-poppt-a-randomized-controlled-trial
#10
Vincenzo Berghella, Lorraine Dugoff, Jack Ludmir
OBJECTIVES: To evaluate if cervical pessary placement prevents PTB in twin gestations with a short midtrimester transvaginal ultrasound (TVU) cervical length (CL). METHODS: Multicenter randomized controlled trial of asymptomatic women with twin gestations with a TVU CL ≤30 mm at 18(0) -27(6) weeks. TVU CL screening was performed at the time of the anatomy scan at 18(0) -23(6) , and at subsequent scheduled ultrasounds prior to 28 weeks. Women with a TVU CL ≤30 mm at 18(0) -27(6) weeks were randomized to receive the Bioteque cup cervical pessary or no pessary...
February 7, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28165249/low-temperature-magnetic-force-microscopy-on-single-molecule-magnet-based-microarrays
#11
Michele Serri, Matteo Mannini, Lorenzo Poggini, Emilio Vélez-Fort, Brunetto Cortigiani, Philippe Sainctavit, Donella Rovai, Andrea Caneschi, Roberta Sessoli
The magnetic properties of some single molecule magnets (SMM) on surfaces can be strongly modified by the molecular packing in nanometric films/aggregates or by interactions with the substrate, which affect the molecular orientation and geometry. Detailed investigations of the magnetism of thin SMM films and nanostructures are necessary for the development of spin-based molecular devices, however this task is challenged by the limited sensitivity of laboratory-based magnetometric techniques and often requires access to synchrotron light sources to perform surface sensitive X-ray magnetic circular dichroism (XMCD) investigations...
March 8, 2017: Nano Letters
https://www.readbyqxmd.com/read/28147654/radiation-pressure-excitation-of-a-low-temperature-atomic-force-magnetic-force-microscope-for-imaging-in-4-300-k-temperature-range
#12
Ümit Çelik, Özgür Karcı, Yiğit Uysallı, H Özgür Özer, Ahmet Oral
We describe a novel radiation pressure based cantilever excitation method for imaging in dynamic mode atomic force microscopy (AFM) for the first time. Piezo-excitation is the most common method for cantilever excitation, however it may cause spurious resonance peaks. Therefore, the direct excitation of the cantilever plays a crucial role in AFM imaging. A fiber optic interferometer with a 1310 nm laser was used both for the excitation of the cantilever at the resonance and the deflection measurement of the cantilever in a commercial low temperature atomic force microscope/magnetic force microscope (AFM/MFM) from NanoMagnetics Instruments...
January 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28087121/upper-extremity-outcome-measures-for-collagen-vi-related-myopathy-and-lama2-related-muscular-dystrophy
#13
Roxanna M Bendixen, Jocelyn Butrum, Mina S Jain, Rebecca Parks, Bonnie Hodsdon, Carmel Nichols, Michelle Hsia, Leslie Nelson, Katherine C Keller, Michelle McGuire, Jeffrey S Elliott, Melody M Linton, Irene C Arveson, Fatou Tounkara, Ruhi Vasavada, Elizabeth Harnett, Monal Punjabi, Sandra Donkervoort, Jahannaz Dastgir, Meganne E Leach, Anne Rutkowski, Melissa Waite, James Collins, Carsten G Bönnemann, Katherine G Meilleur
Congenital muscular dystrophy (CMD) comprises a rare group of genetic muscle diseases that present at birth or early during infancy. Two common subtypes of CMD are collagen VI-related muscular dystrophy (COL6-RD) and laminin alpha 2-related dystrophy (LAMA2-RD). Traditional outcome measures in CMD include gross motor and mobility assessments, yet significant motor declines underscore the need for valid upper extremity motor assessments as a clinical endpoint. This study validated a battery of upper extremity measures in these two CMD subtypes for future clinical trials...
March 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/28046701/su-f-t-89-investigation-of-simultaneous-optimization-of-photon-and-electron-apertures-for-mixed-beam-radiotherapy-based-on-an-academic-case
#14
S Mueller, A Joosten, M K Fix, D Henzen, W Volken, D Frei, Mfm Stampanoni, P Manser
PURPOSE: To estimate the dosimetric potential of mixed beam radiotherapy (MBRT) by using a single process optimizing the shape and weight of photon and electron apertures simultaneously based on Monte Carlo beamlet dose distributions. METHODS: A simulated annealing based direct aperture optimization capable to perform simultaneous optimization was developed to generate treatment plans for MERT, photon-IMRT and MBRT. Both photon and electron apertures are collimated with the photon-MLC and are delivered in a segmented manner...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27904835/a-novel-dominant-d109a-cryab-mutation-in-a-family-with-myofibrillar-myopathy-affects-%C3%AE-b-crystallin-structure
#15
Jakub P Fichna, Anna Potulska-Chromik, Przemysław Miszta, Maria Jolanta Redowicz, Anna M Kaminska, Cezary Zekanowski, Sławomir Filipek
Myofibrillar myopathy (MFM) is a group of inherited muscular disorders characterized by myofibrils dissolution and abnormal accumulation of degradation products. So far causative mutations have been identified in nine genes encoding Z-disk proteins, including αB-crystallin (CRYAB), a small heat shock protein (also called HSPB5). Here, we report a case study of a 63-year-old Polish female with a progressive lower limb weakness and muscle biopsy suggesting a myofibrillar myopathy, and extra-muscular multisystemic involvement, including cataract and cardiomiopathy...
June 2017: BBA Clinical
https://www.readbyqxmd.com/read/27890658/magnetic-mapping-of-iron-in-rodent-spleen
#16
Angela R Blissett, Brooke Ollander, Brittany Penn, Dana M McTigue, Gunjan Agarwal
Evaluation of iron distribution and density in biological tissues is important to understand the pathogenesis of a variety of diseases and the fate of exogenously administered iron-based carriers and contrast agents. Iron distribution in tissues is typically characterized via histochemical (Perl's) stains or immunohistochemistry for ferritin, the major iron storage protein. A more accurate mapping of iron can be achieved via ultrastructural transmission electron microscopy (TEM) based techniques, which involve stringent sample preparation conditions...
November 25, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/27859463/how-many-procedures-does-it-take-success-of-a-cvs-training-program-for-maternal-fetal-medicine-fellows
#17
Alexis C Gimovsky, Sindy C Moreno, Sara Nicholas, Amanda Roman, Stuart Weiner
OBJECTIVES: To quantify the learning curve for a training program for Maternal Fetal Medicine (MFM) fellows in obtaining successful transvaginal chorionic villus sampling (CVS) results in women with early pregnancy failure (EPF). METHODS: Retrospective observational cohort study of transvaginal CVS and subsequent manual vacuum aspiration (MVA) performed by MFM fellows. CVS samples were sent for karyotype, and products of conception (POC) were sent if CVS sample did not yield a result...
December 2016: Prenatal Diagnosis
https://www.readbyqxmd.com/read/27854214/homozygosity-of-the-dominant-myotilin-c-179c-t-p-ser60phe-mutation-causes-a-more-severe-and-proximal-muscular-dystrophy
#18
Gabrielle Rudolf, Tiina Suominen, Sini Penttilä, Peter Hackman, Anni Evilä, Béatrice Lannes, Andoni Echaniz-Laguna, Guillaume Bierry, Christine Tranchant, Bjarne Udd
Most myotilinopathy patients present with a dominant late onset distal phenotype and myofibrillar pathology, although the first MYOT mutation in a family reported to have LGMD phenotype. We report here a French family affected with a late onset proximal and distal muscle weakness and myofibrillar myopathy on muscle pathology, in which the siblings known to be clinically affected were homozygous for the c.179C>T (p.Ser60Phe) myotilin gene mutation. One subjectively asymptomatic member of the family was heterozygous for this mutation...
May 27, 2016: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/27848152/the-presence-and-impact-of-estrogen-metabolism-on-the-biology-of-triple-negative-breast-cancer
#19
Keely May McNamara, Saki Oguro, Fumiya Omata, Kyoko Kikuchi, Fouzia Guestini, Koyu Suzuki, Yang Yang, Eriko Abe, Hisashi Hirakawa, Kristy A Brown, Ishida Takanori, Noriaki Ohuchi, Hironobu Sasano
PURPOSE: While triple-negative breast cancer (TNBC) is negative for estrogen receptor alpha, a substantial proportion of carcinomas express estrogen receptor beta (ERβ); consequently, estrogen actions and metabolism may be relevant in this cancer subtype. METHODS: A cohort of 81 TNBC patients from Tohoku University Hospital, Japan were characterised with regard to the expression of estrogen receptor beta and enzymes known to modulate levels of estrogens in breast and other tissues (Aromatase, 17-beta- Hydroxysteroid dehydrogenases 1, 2 and 6)...
November 15, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27816572/characterization-of-an-insect-heterodimeric-voltage-gated-sodium-channel-with-unique-alternative-splicing-mode
#20
Xuan-Zhao Jiang, Yu-Xia Pei, Wei Lei, Ke-Yi Wang, Feng Shang, Hong-Bo Jiang, Jin-Jun Wang
Recent discovery of the heterodimeric voltage-gated sodium channels (Nav) in two aphid species, Acyrthosiphon pisum and Myzus persicae, aroused interest in exploring whether this kind of channel is conserved for aphids. Herewith, we aim to provide evidence for the conservation of heterodimeric Navs in aphids and investigate whether they have unique splicing patterns. We found that the only identifiable Nav from Toxoptera citricida consisted of two subunits, forming a heterodimeric Nav, which carried an atypical "DENS" ion selectivity filter and a conventional "MFM" inactivation gate, confirming the heterodimeric Navs' conservation within aphids...
January 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
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