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Hriday Bera, Sanoj Kumar, Sabyasachi Maiti
Olive oil-entrapped diethanolamine-modified high-methoxyl pectin (DMP)-gellan gum (GG)-bionanofiller composites were developed for controlled intragastric delivery of metformin HCl (MFM). DMP had a degree of amidation of 48.7% and was characterized further by FTIR, XRD and DSC analyses. MFM-loaded composites were subsequently accomplished by green synthesis via ionotropic gelation technique using zinc acetate as cross-linker. The thermal, X-ray and infrared analyses suggested an environment in the composites compatible with the drug, except certain degree of attenuation in drug's crystallinity...
June 19, 2018: International Journal of Biological Macromolecules
Xue Han, Harry G W Godfrey, Lydia Briggs, Andrew J Davies, Yongqiang Cheng, Luke L Daemen, Alena M Sheveleva, Floriana Tuna, Eric J L McInnes, Junliang Sun, Christina Drathen, Michael W George, Anibal J Ramirez-Cuesta, K Mark Thomas, Sihai Yang, Martin Schröder
Nitrogen dioxide (NO2 ) is a major air pollutant causing significant environmental1,2 and health problems3,4 . We report reversible adsorption of NO2 in a robust metal-organic framework. Under ambient conditions, MFM-300(Al) exhibits a reversible NO2 isotherm uptake of 14.1 mmol g-1 , and, more importantly, exceptional selective removal of low-concentration NO2 (5,000 to <1 ppm) from gas mixtures. Complementary experiments reveal five types of supramolecular interaction that cooperatively bind both NO2 and N2 O4 molecules within MFM-300(Al)...
June 11, 2018: Nature Materials
Songbai Hu, Claudio Cazorla, Feixiang Xiang, Hongfei Ma, Jianyuan Wang, Jianbo Wang, Xiaolin Wang, Clemens Ulrich, Lang Chen, Jan Seidel
Magnetic materials with large magnetic anisotropy are essential for workaday applications such as permanent magnets and magnetic data storage. There is widespread interest in finding efficient ways of controlling magnetic anisotropy, among which strain control has proven to be a very powerful technique. Here we demonstrate strain-mediated magnetic anisotropy in SrCoO3-δ thin film, a perovskite oxide that is metallic and adopts a cubic structure at δ ≤ 0.25. We find that the easy-magnetization axis in SrCoO3-δ can be rotated by 90º upon application of moderate epitaxial strains ranging from -1...
June 8, 2018: ACS Applied Materials & Interfaces
Onaedo Ilozumba, Sara Van Belle, Marjolein Dieleman, Loan Liem, Murari Choudhury, Jacqueline E W Broerse
Background: Mobile technology (mHealth) is increasingly being used to achieve improved access and quality of maternal care, particularly in rural areas of low- and middle-income countries. In 2011, a mobile application-Mobile for Mothers (MfM)-was implemented in Jharkhand, India to support home visits by community health workers. The objective of this study is to assess the impact of the mHealth intervention on maternal health. Methods: Households from three subdistricts in the Deoghar district of Jharkhand were selected using a multistage cluster sampling approach...
2018: Frontiers in Public Health
Jing Miao, Fei-Fei Su, Xue-Mei Liu, Xiao-Jing Wei, Yun Yuan, Xue-Fan Yu
BACKGROUND: Filamin C-related myofibrillar myopathies (MFM) are progressive skeletal myopathies with an autosomal dominant inheritance pattern. The conditions are caused by mutations of the filamin C gene (FLNC) located in the chromosome 7q32-q35 region. Genetic variations in the FLNC gene result in various clinical phenotypes. CASE PRESENTATION: We describe a 43-year-old woman who suffered filamin C-related MFM, with symptoms first presenting in the proximal muscles of the lower limbs and eventually spreading to the upper limbs and distal muscles...
June 4, 2018: BMC Neurology
Michael P Morran, Ali G Al-Dieri, Andrea L Nestor-Kalinoski, Richard K Jordan, Nirdesh K Gupta, Marcia F McInerney
The insulin receptor (IR) is a transmembrane receptor which recognizes and binds the hormone insulin. We describe two models that were devised to explore the role of IR over-expression on T-lymphocytes and their chemotactic motility in the progression of type 1 diabetes. FVB/NJ-CD3-3×FLAG-mIR/MFM mice were generated to selectively over-express 3×FLAG tagged murine IR in T-lymphocytes via an engineered CD3 enhancer and promoter construct. Insertion of the 3×FLAG-mIR transgene into FVB/NJ mice, a known non-autoimmune prone strain, lead to a minor population of detectable 3×FLAG-mIR tagged T-lymphocytes in peripheral blood and the presence of a few lymphocytes in the pancreas of the Tg+/- compared to age matched Tg-/- control mice...
2018: Journal of Biological Methods
Ruchi Amin, Aaron Domack, Joseph Bartoletti, Erika Peterson, Britton Rink, Jennifer Bruggink, Melissa Christensen, Anthony Johnson, William Polzin, Amy J Wagner
BACKGROUND: Gastroschisis is an abdominal wall defect with increasing incidence. Given the lack of surveillance guidelines among maternal-fetal medicine (MFM) specialists, this study describes current practices in gastroschisis management. MATERIALS AND METHODS: An online survey was administered to MFM specialists from institutions affiliated with the North American Fetal Therapy Network (NAFTNet). Questions focused on surveillance timing, testing, findings that changed clinical management, and delivery plan...
May 23, 2018: Fetal Diagnosis and Therapy
Zhenzhong Lu, Harry G W Godfrey, Ivan da Silva, Yongqiang Cheng, Mathew Savage, Pascal Manuel, Svemir Rudić, Anibal J Ramirez-Cuesta, Sihai Yang, Martin Schröder
Fine tuning of host-guest supramolecular interactions in porous systems enables direct control over the properties of functional materials. We report here a modification of hydrogen bonding and its effect on guest binding in a pair of redox-active metal-organic frameworks (MOFs). Oxidation of MFM-300(VIII ) {[VIII2(OH)2 (L)], LH4 = biphenyl-3,3',5,5'-tetracarboxylic acid} is accompanied by deprotonation of the bridging hydroxyl groups to afford isostructural MFM-300(VIV ), [VIV2O2 (L)]. The precise role of the hydroxyl groups, O -carboxylate centres and π-π interactions in the supramolecular binding of C2 hydrocarbons in these materials has been determined using neutron diffraction and inelastic neutron scattering, coupled with DFT modelling...
April 7, 2018: Chemical Science
Jana Trojková, Ondřej Životský, Aleš Hendrych, Dmitry Markov, Klára Drobíková
The magnetic domain patterns of amorphous bilayered FeSiB/FeNbSiB and FeNbCuSiB/CoSiB ribbons are observed and analysed using the magneto-optical Kerr microscopy (MOKM) and magnetic force microscopy (MFM). Both microscopic techniques are highly sensitive to the sample surface; possibility of Kerr microscopy to visualize the domains separately in both layers is achieved by focusing the laser spot on the ribbon cross section. Wide curved domains as well as fine fingerprint domains were detected at the surface of ribbons due to presence of local stresses coming from the preparation process...
2018: Scanning
Woo Young Jang, Dong Yeon Lee, Hae Woon Jung, Doo Jae Lee, Won Joon Yoo, In Ho Choi
BACKGROUND: Several multi-segment foot models (MFMs) have been introduced for in vivo analyses of dynamic foot kinematics. However, the normal gait patterns of healthy children and adolescents remain uncharacterized. We sought to determine normal foot kinematics according to age in clinically normal female children and adolescents using a Foot 3D model. METHODS: Fifty-eight girls (age 7-17 years) with normal function and without radiographic abnormalities were tested...
May 6, 2018: Gait & Posture
Jacquelyn Blackstone, Vanessa K Will, William F Rayburn
OBJECTIVE:  To examine trends of female physicians either pursuing fellowships or in active practice in maternal-fetal medicine (MFM). METHODS:  This observational study examined complete sets of MFM fellows and active members of the Society for Maternal-Fetal Medicine (SMFM) between 1985 and 2016. Databases from SMFM, American College of Obstetricians and Gynecologists (ACOG), and Accreditation Council for Graduate Medical Education were used. Analysis of covariance testing was used to assess interactions over time between groups...
May 7, 2018: American Journal of Perinatology
Yongze Cao, Shota Nakayama, Pawan Kumar, Yue Zhao, Yukinori Kinoshita, Satoru Yoshimura, Hitoshi Saito
For magnetic domain imaging, with a very high spatial resolution magnetic force microscope, the tip-sample distance should be as small as possible. However, magnetic imaging near the sample surface is very difficult with conventional magnetic force microscopy (MFM) because the interactive forces between the tip and sample include van der Waals and electrostatic forces along with a magnetic force. In this study, we proposed alternating MFM which only extracts a magnetic force near the sample surface without any topographic and electrical crosstalk...
July 27, 2018: Nanotechnology
Federico Venturi, Gian Carlo Gazzadi, Amir H Tavabi, Alberto Rota, Rafal E Dunin-Borkowski, Stefano Frabboni
The magnetic properties of nanowires (NWs) and square nanorings, which were deposited by focused electron beam induced deposition (FEBID) of a Co carbonyl precursor, are studied using off-axis electron holography (EH), Lorentz transmission electron microscopy (L-TEM) and magnetic force microscopy (MFM). EH shows that NWs deposited using beam energies of 5 and 15 keV have the characteristics of magnetic dipoles, with larger magnetic moments observed for NWs deposited at lower energy. L-TEM is used to image magnetic domain walls in NWs and nanorings and their motion as a function of applied magnetic field...
2018: Beilstein Journal of Nanotechnology
Paul Roberts, Georgia A Pilkington, Yumo Wang, Joelle Frechette
We present the multifunctional force microscope (MFM), a normal and lateral force-measuring instrument with in situ imaging. In the MFM, forces are calculated from the normal and lateral deflection of a cantilever as measured via fiber optic sensors. The motion of the cantilever is controlled normally by a linear micro-translation stage and a piezoelectric actuator, while the lateral motion of the sample is controlled by another linear micro-translation stage. The micro-translation stages allow for travel distances that span 25 mm with a minimum step size of 50 nm, while the piezo has a minimum step size of 0...
April 2018: Review of Scientific Instruments
Kyeong-Jun Kim, Hyeon-Yeol Cho, Won-Jun Lee, Jeong-Woo Choi
Circulating tumor cell (CTC) which recently arisen as potential sources for monitoring and characterizing non-haematologic cancers and their metastatic derivatives. Immunomagnetic microbeads and magnetic nanoparticles (MNPs) have been extensively explored to isolate CTCs from blood samples. However, MNPs attached on the membrane protein are interrupted further analysis to distinguish the cancer subtype by consumption or blocking the target surface marker. Here, an MNP-mediated analysis method for surface marker expression profile by magnetic force microscopy (MFM) is described...
June 2018: Biotechnology Journal
Claudia Rezende Gomes Alves, Márcia Martins Marques, Maria Stella Moreira, Sueli Patricia Harumi Miyagi de Cara, Carlos Eduardo Silveira Bueno, Cesar Ângelo Lascala
Introduction: The second canal of the mesiobuccal root (MB2) of the maxillary first molars (MFM) is difficult to detect in conventional radiographs and can be a major cause of failure in endodontic treatments. The aim of this study was to investigate the prevalence and anatomy of the MB2 by using high-resolution cone-beam computed tomography (CBCT). Methods and Materials: Three radiologists examined 414 high-resolution CBCTs. Of these, the CBCTs of 287 patients (mean age 49...
2018: Iranian Endodontic Journal
Mohamed Salaheldeen, Victor Vega, Angel Ibabe, Miriam Jaafar, Agustina Asenjo, Agustin Fernandez, Victor M Prida
In this article, the magnetic properties of hexagonally ordered antidot arrays made of Dy13 Fe87 alloy are studied and compared with corresponding ones of continuous thin films with the same compositions and thicknesses, varying between 20 nm and 50 nm. Both samples, the continuous thin films and antidot arrays, were prepared by high vacuum e-beam evaporation of the alloy on the top-surface of glass and hexagonally self-ordered nanoporous alumina templates, which serve as substrates, respectively. By using a highly sensitive magneto-optical Kerr effect (MOKE) and vibrating sample magnetometer (VSM) measurements an interesting phenomenon has been observed, consisting in the easy magnetization axis transfer from a purely in-plane (INP) magnetic anisotropy to out-of-plane (OOP) magnetization...
April 8, 2018: Nanomaterials
Tiffanie Guillot, Sylvain Roche, Pascal Rippert, Dalil Hamroun, Jean Iwaz, René Ecochard, Carole Vuillerot
OBJECTIVE: To examine whether a Rasch analysis is sufficient to establish the construct validity of the Motor Function Measure (MFM) and discuss whether weighting the MFM item scores would improve the MFM construct validity. DESIGN: Observational cross-sectional multicenter study. SETTING: Twenty-three physical medicine departments, neurology departments, or reference centers for neuromuscular diseases. PARTICIPANTS: Patients (N=911) aged 6 to 60 years with Charcot-Marie-Tooth disease (CMT), facioscapulohumeral dystrophy (FSHD), or myotonic dystrophy type 1 (DM1)...
April 3, 2018: Archives of Physical Medicine and Rehabilitation
Walid Ibrahim, Konstantinos Spanos, Andreas Gussmann, Christoph A Nienaber, Joerg Tessarek, Heinrich Walter, Jörg Thalwitzer, Sebastian E Debus, Nikolaos Tsilimparis, Tilo Kölbel
OBJECTIVE: The objective of this study was to assess the early and midterm outcomes of endovascular repair of complex aortic aneurysm cases using the Multilayer Flow Modulator (MFM; Cardiatis, Isnes, Belgium) endograft in Germany. METHODS: A retrospective study including patients presenting with abdominal aortic aneurysm (AAA), thoracic aortic aneurysm, or thoracoabdominal aortic aneurysm treated with the MFM was conducted in Germany. Mortality and morbidity (in terms of spinal cord ischemia, visceral ischemia, and stroke) at 30 days postoperatively were evaluated...
March 27, 2018: Journal of Vascular Surgery
Atiwat Soontornpun, Tararak Choovanichvong, Theera Tongsong
OBJECTIVE: The objective of this study was to compare adverse pregnancy outcomes between pregnancies that involve epilepsy and those that do not and are identified as normal for the purposes of this paper. METHODS: A retrospective cohort study was carried out by accessing the maternal-fetal medicine (MFM) database to identify and review records of singleton pregnancies with epilepsy but with no other underlying disease (study group). A parallel group of low-risk pregnancies was randomly allocated as the control group...
May 2018: Epilepsy & Behavior: E&B
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