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https://www.readbyqxmd.com/read/28343081/simultaneous-determination-of-226-ra-228-ra-and-210-pb-in-drinking-water-using-3m-empore%C3%A2-rad-disk-by-lsc-pls
#1
Jordi Fons-Castells, Javier Oliva, Joana Tent-Petrus, Montserrat Llauradó
A procedure for the rapid and simultaneous determination of (226)Ra, (228)Ra and (210)Pb in drinking water by means of extraction with a 3M Empore™ Radium RAD disk and liquid scintillation spectrometry is described. The selective elution of (210)Pb from the RAD disk and a multivariate calibration using partial least squares regression (PLS) are tested as methods to avoid overlap in the spectra between (228)Ra and (210)Pb. The validated procedure was tested with mixtures of radionuclides and interlaboratory materials; finally, it was applied to natural waters...
March 21, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28336890/in-vitro-comparative-skin-irritation-induced-by-nano-and-non-nano-zinc-oxide
#2
Maria Pilar Vinardell, Hector Llanas, Laura Marics, Montserrat Mitjans
This study was designed to determine whether nano-sized ZnO has the potential to cause acute cutaneous irritation using cultured HaCaT keratinocytes and a human skin equivalent as in vitro models, compared to non-nanomaterials. Commercial nano ZnO with different sizes (50 nm and 100 nm) was characterized by dynamic light scattering (DLS) and microscopy (SEM) in different media. Nano ZnO reduced the cell viability of HaCaT in a dose-dependent and time-dependent manner, in a similar way to macro ZnO. However, the 3D-epidermis model revealed no irritation at 1 mg/mL after 24 h of exposure...
March 4, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28334646/defluoridation-of-drinking-water-using-a-new-flow-column-electrocoagulation-reactor-fcer-experimental-statistical-and-economic-approach
#3
Khalid S Hashim, Andy Shaw, Rafid Al Khaddar, Montserrat Ortoneda Pedrola, David Phipps
A new batch, flow column electrocoagulation reactor (FCER) that utilises a perforated plate flow column as a mixer has been used to remove fluoride from drinking water. A comprehensive study has been carried out to assess its performance. The efficiency of fluoride removal (R%) as a function of key operational parameters such as initial pH, detention time (t), current density (CD), inter-electrode distance (ID) and initial concentration (C0) has been examined and an empirical model has been developed. A scanning electron microscopy (SEM) investigation of the influence of the EC process on morphology of the surface of the aluminium electrodes, showed the erosion caused by aluminium loss...
March 20, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28333231/tolerability-of-integrase-inhibitors-in-a-real-life-setting
#4
Judit Peñafiel, Elisa de Lazzari, Mireia Padilla, Jhon Rojas, Ana Gonzalez-Cordon, Jose L Blanco, Jordi Blanch, Maria A Marcos, Montserrat Lonca, Maria Martinez-Rebollar, Montserrat Laguno, Amparo Tricas, Ana Rodriguez, Josep Mallolas, Jose M Gatell, Esteban Martinez
Background: Integrase inhibitors have shown better tolerability than other drugs in clinical trials, but some post-marketing data have suggested potential differences among them. Aims: We compared rates and reasons for discontinuation of raltegravir-, elvitegravir- and dolutegravir-based regimens in a large cohort of HIV-infected patients. Methods: Retrospective analysis of a prospectively followed cohort including all antiretroviral-naive and all virologically suppressed antiretroviral-experienced patients prescribed a first regimen containing raltegravir, elvitegravir or dolutegravir with at least one follow-up visit...
February 28, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28331962/sex-combs-reduced-scr-regulatory-region-of-drosophila-revisited
#5
Juan M Calvo-Martín, Montserrat Papaceit, Carmen Segarra
The Hox gene Sex combs reduced (Scr) is responsible for the differentiation of the labial and prothoracic segments in Drosophila. Scr is expressed in several specific tissues throughout embryonic development, following a complex path that must be coordinated by an equally complex regulatory region. Although some cis-regulatory modules (CRMs) have been identified in the Scr regulatory region (~75 kb), there has been no detailed and systematic study of the distinct regulatory elements present within this region...
March 22, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/28331738/sentinel-node-biopsy-in-special-histologic-types-of-invasive-breast-cancer
#6
Montserrat Solà, Mireia Recaj, Eva Castellà, Pere Puig, Josep Maria Gubern, Juan Francisco Julian, Manel Fraile
OBJECTIVE: To assess the feasibility of sentinel node biopsy (SNB) in ductal and lobular invasive breast cancer, a group of tumors known as special histologic type (SHT) of breast cancer. MATERIALS AND METHODS: Between January 1997 and July 2008, 2253 patients from 6 affiliated hospitals underwent SNB who had early breast cancer and clinically negative axilla. The patients' data were collected in a multicenter database. For lymphatic mapping, all patients received an intralesional dose of radiocolloid Tc-99m (4mCi in 0...
April 2016: J Breast Health (2013)
https://www.readbyqxmd.com/read/28331068/mutations-in-efl1-an-sbds-partner-are-associated-with-infantile-pancytopenia-exocrine-pancreatic-insufficiency-and-skeletal-anomalies-in-a-shwachman-diamond-like-syndrome
#7
Polina Stepensky, Montserrat Chacón-Flores, Katherine H Kim, Omar Abuzaitoun, Arnulfo Bautista-Santos, Natalia Simanovsky, Dritan Siliqi, Davide Altamura, Alfonso Méndez-Godoy, Abril Gijsbers, Adeeb Naser Eddin, Talia Dor, Joel Charrow, Nuria Sánchez-Puig, Orly Elpeleg
BACKGROUND: For the final step of the maturation of the ribosome, the nascent 40S and 60S subunits are exported from the nucleus to the cell cytoplasm. To prevent premature association of these ribosomal subunits, eukaryotic initiation factor 6 (eIF6) binds the 60S subunit within the nucleus. Its release in the cytoplasm requires the interaction of EFL1 and SDBS proteins. In Shwachman-Diamond syndrome (SDS), a defective SDBS protein prevents eIF6 eviction, inhibiting its recycle to the nucleus and subsequent formation of the active 80S ribosome...
March 22, 2017: Journal of Medical Genetics
https://www.readbyqxmd.com/read/28328995/effectiveness-of-interceptive-treatment-of-class-iii-malocclusions-with-skeletal-anchorage-a-systematic-review-and-meta-analysis
#8
Jorge Rodríguez de Guzmán-Barrera, Carla Sáez Martínez, Montserrat Boronat-Catalá, Jose María Montiel-Company, Vanessa Paredes-Gallardo, José Luís Gandía-Franco, José Manuel Almerich-Silla, Carlos Bellot-Arcís
Recently, new strategies for treating class III malocclusions have appeared. Skeletal anchorage appears to reduce the dentoalveolar effects while maximising the orthopaedic effect in growing patients. The purpose of this systematic review and meta-analysis is to examine the effectiveness of bone anchorage devices for interceptive treatment of skeletal class III malocclusions. Searches were made in the Pubmed, Embase, Scopus and Cochrane databases, as well as in a grey literature database, and were complemented by hand-searching...
2017: PloS One
https://www.readbyqxmd.com/read/28324150/stress-stones-stress-recurrent-stones-a-self-propagating-cycle-difficulties-in-solving-this-dichotomy
#9
Montserrat Arzoz-Fabregas, Josep Roca-Antonio, Luis Ibarz-Servio, Dalielah Jappie-Mahomed, Allen Rodgers
Numerous studies have reported an association between stress and urolithiasis. Although urinary risk factors have been measured in several of these, compelling evidence of a causal relationship has not been established. A shortcoming is that alterations in single urinary parameters rather than ratios and quotients, which provide a more synergistic risk evaluation, have been measured. Recently, we speculated about a possible association between chronic stress and stone recurrence. This presents an intriguing dichotomy of whether stress causes stones or vice versa, or whether they are linked in a self-propagating stress-stones-stress-recurrence cycle...
March 21, 2017: Urolithiasis
https://www.readbyqxmd.com/read/28323980/hypoxia-inducible-lipid-droplet-associated-hilpda-is-not-a-direct-physiological-regulator-of-lipolysis-in-adipose-tissue
#10
Wieneke Dijk, Frits Mattijssen, Montserrat de la Rosa Rodriguez, Angel Loza Valdes, Anne Loft, Susanne Mandrup, Eric Kalkhoven, Ling Qi, Jan Willem Borst, Sander Kersten
Triglycerides are stored in specialized organelles called lipid droplets. Numerous proteins have been shown to be physically associated with lipid droplets and govern their function. Previously, hypoxia-inducible lipid droplet-associated (HILPDA) was localized to lipid droplets and was suggested to inhibit triglyceride lipolysis in hepatocytes. We confirm the partial localization of HILPDA to lipid droplets and show that HILPDA is highly abundant in adipose tissue, where its expression is controlled by the peroxisome proliferator-activated receptor γ and by β-adrenergic stimulation...
March 17, 2017: Endocrinology
https://www.readbyqxmd.com/read/28323949/plasma-arginine-asymmetric-dimethylarginine-ratio-and-incidence-of-cardiovascular-events-a-case-cohort-study
#11
Edward Yu, Miguel Ruiz-Canela, Frank B Hu, Clary B Clish, Dolores Corella, Jordi Salas-Salvadó, Adela Hruby, Montserrat Fitó, Liming Liang, Estefania Toledo, Emilio Ros, Ramón Estruch, Enrique Gómez-Gracia, Jose Lapetra, Fernando Arós, Dora Romaguera, Lluís Serra-Majem, Marta Guasch-Ferré, Dong D Wang, Miguel A Martínez-González
CONTEXT: Arginine, its methylated metabolites and other metabolites related to the urea cycle have been independently associated with cardiovascular risk, but the potential causal meaning of these associations (positive for some metabolites and negative for others) remains elusive due to a lack of studies measuring metabolite changes over time. OBJECTIVE: To examine the association between baseline and 1-year concentrations of urea cycle metabolites and cardiovascular disease in a case-cohort setting...
March 2, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28322000/postprandial-triglyceride-rich-lipoproteins-promote-lipid-accumulation-and-apolipoprotein-b-48-receptor-transcriptional-activity-in-human-circulating-and-murine-bone-marrow-neutrophils-in-a-fatty-acid-dependent-manner
#12
Almudena Ortega-Gómez, Lourdes M Varela, Sergio Lopez, Sergio Montserrat de la Paz, Rosario Sanchez, Francisco J G Muriana, Beatriz Bermúdez, Rocío Abia
SCOPE: Postprandial triglyceride-rich lipoproteins (TRLs) promote atherosclerosis. Recent research points the bone marrow (BM) as a primary site in atherosclerosis. We elucidated how the acute administration of MUFAs, omega-3 PUFAs and saturated fatty acids (SFAs) affects human circulating and murine BM neutrophil lipid accumulation and functionality. METHODS AND RESULTS: Postprandial hypertriglyceridemia was induced in healthy subjects and Apoe-/- mice by the acute administration of dietary fats enriched in MUFAs, PUFAs or SFAs...
March 21, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28315721/current-outcomes-and-predictors-of-treatment-failure-in-patients-with-surgical-site-infection-after-elective-colorectal-surgery-a-multicentre-prospective-cohort-study
#13
Aina Gomila, Josep Ma Badia, Jordi Carratalà, Xavier Serra-Aracil, Evelyn Shaw, Vicens Diaz-Brito, Antoni Castro, Elena Espejo, Carmen Nicolás, Marta Piriz, Montserrat Brugués, Josefina Obradors, Ana Lérida, Jordi Cuquet, Enric Limón, Francesc Gudiol, Miquel Pujol
OBJECTIVE: To determine current outcomes and predictors of treatment failure among patients with surgical site infection (SSI) after colorectal surgery. METHODS: A multicentre observational prospective cohort study of adults undergoing elective colorectal surgery in 10 Spanish hospitals (2011-2014). Treatment failure was defined as persistence of signs/symptoms of SSI or death at 30 days post-surgery. RESULTS: Of 3,701 patients, 669 (18.1%) developed SSI; 336 (9...
March 15, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28315038/the-mirror-neuron-system-in-relapsing-remitting-multiple-sclerosis-patients-with-low-disability
#14
Julio Plata-Bello, Yaiza Pérez-Martín, Abril Castañón-Pérez, Cristián Modroño, Helga Fariña, Estefanía Hernández-Martín, Montserrat González-Platas, Francisco Marcano, José Luis González-Mora
To study the visuospatial/visuoperceptive function using a mirror neuron system (MNS) based approach in multiple sclerosis (MS) patients and a healthy control group. Two task-based fMRIs (an execution task and an observation task) and one resting-fMRI were performed in a group of MS patients (n = 24) and a group of healthy controls (n = 15). The execution and observation tasks consisted of the performance or observation of the index-thumb opposition task. Statistical parametric mapping approaches were used to identify differences in the brain activity and functional connectivity (FC) of the MNS between MS patients and healthy controls...
March 17, 2017: Brain Topography
https://www.readbyqxmd.com/read/28301455/-characteristics-of-communication-systems-of-suspected-occupational-disease-in-the-autonomous-communities-spain
#15
Montserrat García Gómez, Félix Urbaneja Arrúe, Vega García López, Valentín Estaban Buedo, Valentín Rodríguez Suárez, Lourdes Miralles Martínez-Portillo, Isabel González García, Josefa Egea Garcia, Emma Corraliza Infanzon, Laura Ramírez Salvador, Santiago Briz Blázquez, Ricard Armengol Rosell, José María Cisnal Gredilla, Juan Francisco Correa Rodríguez, Juan Carlos Coto Fernández, Mª Rosario Díaz Peral, Mercedes Elvira Espinosa, Iñigo Fernández Fernández, Eduardo García-Ramos Alonso, Nieves Martínez Arguisuelas, Ana Isabel Rivas Pérez
BACKGROUND: There are several initiatives to develop systems for the notification of suspected occupational disease (OD) in different autonomous communities. The objective was to describe the status of development and characteristics of these systems implemented by the health authorities. METHODS: A cross-sectional descriptive study was carried out on the existence of systems for the information and surveillance of suspected OD, their legal framework, responsible institution and availability of information...
March 17, 2017: Revista Española de Salud Pública
https://www.readbyqxmd.com/read/28300571/sleep-apnea-and-hypertension-are-there-gender-differences-the-vitoria-sleep-cohort
#16
Irene Cano-Pumarega, Ferrán Barbé, Andrés Esteban, Montserrat Martínez-Alonso, Carlos Egea, Joaquín Durán-Cantolla
BACKGROUND: Evidence from longitudinal studies has reported contradictory results regarding the association between obstructive sleep apnea (OSA) and hypertension. In a previous analysis of the Vitoria Sleep Cohort, we evaluated the relationship between OSA and the risk of developing hypertension and we did not find an independent association after adjustment for confounding factors. In the present study, we perform a post hoc analysis to assess the association between OSA and incident stage 2 hypertension (systolic blood pressure ≥ 160 mmHg and/or diastolic blood pressure ≥ 100 mmHg) based on gender differences...
March 11, 2017: Chest
https://www.readbyqxmd.com/read/28300223/role-of-cyclooxygenase-2-on-intermittent-hypoxia-induced-lung-tumor-malignancy-in-a-mouse-model-of-sleep-apnea
#17
Noelia Campillo, Marta Torres, Antoni Vilaseca, Paula Naomi Nonaka, David Gozal, Jordi Roca-Ferrer, César Picado, Josep Maria Montserrat, Ramon Farré, Daniel Navajas, Isaac Almendros
An adverse role for obstructive sleep apnea (OSA) in cancer epidemiology and outcomes has recently emerged from clinical and animal studies. In animals, intermittent hypoxia (IH) mimicking OSA promotes tumor malignancy both directly and via host immune alterations. We hypothesized that IH could potentiate cancer aggressiveness through activation of the cyclooxygenase-2 (COX-2) pathway and the concomitant increases in prostaglandin E2 (PGE2). The contribution of the COX-2 in IH-induced enhanced tumor malignancy was assessed using celecoxib as a COX-2 specific inhibitor in a murine model of OSA bearing Lewis lung carcinoma (LLC1) tumors...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28293472/learning-and-memory-disabilities-in-iugr-babies-functional-and-molecular-analysis-in-a-rat-model
#18
Marta Camprubí Camprubí, Rafel Balada Caballé, Juan A Ortega Cano, Maria de Los Angeles Ortega de la Torre, Cristina Duran Fernández-Feijoo, Montserrat Girabent-Farrés, Josep Figueras-Aloy, Xavier Krauel, Soledad Alcántara
INTRODUCTION: 1Intrauterine growth restriction (IUGR) is the failure of the fetus to achieve its inherent growth potential, and it has frequently been associated with neurodevelopmental problems in childhood. Neurological disorders are mostly associated with IUGR babies with an abnormally high cephalization index (CI) and a brain sparing effect. However, a similar correlation has never been demonstrated in an animal model. The aim of this study was to determine the correlations between CI, functional deficits in learning and memory and alterations in synaptic proteins in a rat model of IUGR...
March 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28289747/physiotherapy-treatments-in-musculoskeletal-pathologies-associated-with-haemophilia-a-literature-review
#19
Jesús Guodemar-Pérez, Montserrat Ruiz-López, Elena Rodríguez-López, Pablo García-Fernández, Juan Pablo Hervás-Pérez
The aim of this study is to offer physiotherapists a synthesis of the main therapeutic tools available for the treatment of musculoskeletal pathologies in patients with haemophilia, according to the scientific literature. Although bleeds are recognised as no longer being a cause of death for people with haemophilia, the accompanying musculoskeletal injuries now represent the main problem associated with this disorder. There is a lack of clear guidelines to date regarding the physiotherapy treatment of these disorders...
March 14, 2017: Hämostaseologie
https://www.readbyqxmd.com/read/28289213/new-middle-pleistocene-hominin-cranium-from-gruta-da-aroeira-portugal
#20
Joan Daura, Montserrat Sanz, Juan Luis Arsuaga, Dirk L Hoffmann, Rolf M Quam, María Cruz Ortega, Elena Santos, Sandra Gómez, Angel Rubio, Lucía Villaescusa, Pedro Souto, João Mauricio, Filipa Rodrigues, Artur Ferreira, Paulo Godinho, Erik Trinkaus, João Zilhão
The Middle Pleistocene is a crucial time period for studying human evolution in Europe, because it marks the appearance of both fossil hominins ancestral to the later Neandertals and the Acheulean technology. Nevertheless, European sites containing well-dated human remains associated with an Acheulean toolkit remain scarce. The earliest European hominin crania associated with Acheulean handaxes are at the sites of Arago, Atapuerca Sima de los Huesos (SH), and Swanscombe, dating to 400-500 ka (Marine Isotope Stage 11-12)...
March 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
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