Cathy M Jacobs, Julia C Radosa, Lea Wagmann, Julia S M Zimmermann, Askin C Kaya, Aylin Aygün, Tatjana Edel, Lisa Stotz, Mohamed Ismaeil, Erich-Franz Solomayer, Markus R Meyer
Oral endocrine therapies (OET) for breast cancer treatment need to be taken over a long period of time and are associated with considerable side effects. Therefore, adherence to OET is an important issue and of high clinical significance for breast cancer patients' caregivers. We hypothesized that a new bioanalytical strategy based on liquid chromatography and high-resolution mass spectrometry might be suitable for unbiased adherence monitoring (AM) of OET. Four different biomatrices (plasma, urine, finger prick blood by volumetric absorptive microsampling (VAMS), oral fluid (OF)) were evaluated regarding their suitability for AM of the OET abemaciclib, anastrozole, exemestane, letrozole, palbociclib, ribociclib, tamoxifen, and endoxifen...
March 15, 2024: Analytical and Bioanalytical Chemistry