keyword
https://read.qxmd.com/read/38489294/drug-loaded-polydopamine-nanoparticles-for-chemo-photothermal-therapy-against-colorectal-cancer-cells
#21
JOURNAL ARTICLE
Alessio Carmignani, Matteo Battaglini, Attilio Marino, Francesca Pignatelli, Gianni Ciofani
Colorectal cancer (CRC) is a common and deadly malignancy, ranking second in terms of mortality and third in terms of incidence on a global scale. The survival rates for CRC patients are unsatisfactory primarily because of the absence of highly effective clinical strategies. The efficacy of existing CRC treatments, such as chemotherapy (CT), is constrained by issues such as drug resistance and damage to healthy tissues. Alternative approaches such as photothermal therapy (PTT), while offering advantages over traditional therapies, suffer instead from a low efficiency in killing tumor cells when used alone...
March 15, 2024: ACS Applied Bio Materials
https://read.qxmd.com/read/38489247/discovery-of-new-tricyclic-oxime-sampangine-derivatives-as-potent-antifungal-agents-for-the-treatment-of-cryptococcosis-and-candidiasis
#22
JOURNAL ARTICLE
Wanzhen Yang, Ruxiong Liu, Zhuang Li, Jie Tu, Dongjian Xu, Na Liu, Chunquan Sheng
Cryptococcus neoformans ( C. neoformans ) and Candida albicans ( C. albicans ) are classified as the critical priority groups among the pathogenic fungi, highlighting the urgent need for developing more effective antifungal therapies. On the basis of antifungal natural product sampangine, herein, a series of tricyclic oxime and oxime ether derivatives were designed. Among them, compound WZ-2 showed excellent inhibitory activity against C. neoformans (MIC80 = 0.016 μg/mL) and synergized with fluconazole to treat resistant C...
March 15, 2024: Journal of Medicinal Chemistry
https://read.qxmd.com/read/38489183/alzheimer-s-disease-immunotherapy-current-strategies-and-future-prospects
#23
REVIEW
Ali Aljassabi, Tarek Zieneldien, Janice Kim, Deepika Regmi, Chuanhai Cao
Alzheimer's disease (AD) is an extremely complex and heterogeneous pathology influenced by many factors contributing to its onset and progression, including aging, amyloid-beta (Aβ) plaques, tau fibril accumulation, inflammation, etc. Despite promising advances in drug development, there is no cure for AD. Although there have been substantial advancements in understanding the pathogenesis of AD, there have been over 200 unsuccessful clinical trials in the past decade. In recent years, immunotherapies have been at the forefront of these efforts...
March 14, 2024: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/38488985/surgical-treatment-for-type-a-aortic-dissection-after-endovascular-aortic-repair-a-12-year-single-center-study
#24
JOURNAL ARTICLE
Yuan Xue, Shipan Wang, Xuehuan Zhang, Xiaomeng Wang, Yue Shi, Hongjia Zhang, Duanduan Chen, Haiyang Li
OBJECTIVE: This study aims to investigate the clinical manifestations, operative techniques, and outcomes of patients who undergo open repair after thoracic endovascular aortic repair (TEVAR). METHODS: From January 2010 to June 2022, 113 consecutive type A aortic dissection (TAAD) patients underwent secondary open operation after TEVAR at our institution, and the median interval from primary intervention to open surgery was 12 (1.9-48.0) months. We divided the patients into two groups (RTAD (retrograde type A dissection) group, N = 56; PNAD (proximal new aortic dissection) group, N = 57) according to their anatomical features...
March 15, 2024: Cardiovascular Drugs and Therapy
https://read.qxmd.com/read/38488952/towards-clinical-adherence-monitoring-of-oral-endocrine-breast-cancer-therapies-by-lc-hrms-method-development-validation-comparison-of-four-sample-matrices-and-proof-of-concept
#25
JOURNAL ARTICLE
Cathy M Jacobs, Julia C Radosa, Lea Wagmann, Julia S M Zimmermann, Askin C Kaya, Aylin Aygün, Tatjana Edel, Lisa Stotz, Mohamed Ismaeil, Erich-Franz Solomayer, Markus R Meyer
Oral endocrine therapies (OET) for breast cancer treatment need to be taken over a long period of time and are associated with considerable side effects. Therefore, adherence to OET is an important issue and of high clinical significance for breast cancer patients' caregivers. We hypothesized that a new bioanalytical strategy based on liquid chromatography and high-resolution mass spectrometry might be suitable for unbiased adherence monitoring (AM) of OET. Four different biomatrices (plasma, urine, finger prick blood by volumetric absorptive microsampling (VAMS), oral fluid (OF)) were evaluated regarding their suitability for AM of the OET abemaciclib, anastrozole, exemestane, letrozole, palbociclib, ribociclib, tamoxifen, and endoxifen...
March 15, 2024: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/38488848/selective-anticervical-cancer-injectable-and-self-healable-hydrogel-platforms-constructed-of-drug-loaded-cross-linkable-unimolecular-micelles-in-a-single-and-combination-therapy
#26
JOURNAL ARTICLE
Monika Gosecka, Mateusz Gosecki, Piotr Ziemczonek, Malgorzata Urbaniak, Ewelina Wielgus, Monika Marcinkowska, Anna Janaszewska, Barbara Klajnert-Maculewicz
In the face of severe side effects of systemic chemotherapy used in cervical cancer, topical selective drug carriers with long-lasting effects are being sought. Hydrogels are suitable platforms, but their use is problematic in the case of delivery of hydrophobic drugs with anticancer activity. Herein, hydrogels constructed of unimolecular micelles displaying enhanced solubilization of aromatic lipophilic bioactive compounds are presented. Star-shaped poly(benzyl glycidyl ether)- block -poly(glycidyl glycerol ether) with an aryl-enriched core show high encapsulation capacity of poor water-soluble nifuratel and clotrimazole...
March 15, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38488682/exploring-the-impact-of-itgb2-on-glioma-progression-and-treatment-insights-from-non-apoptotic-cell-death-and-immunotherapy
#27
JOURNAL ARTICLE
Junhong Zhuang, Changfeng Miao, Chao Liu, Biying Zeng, Linwang Hu, Jun Peng, Ying Xia, Zigui Chen
In the realm of glioma treatment, our groundbreaking research has uncovered the pivotal role of Integrin Beta 2 (ITGB2) in non-apoptotic cell death and its profound implications for immunotherapy efficacy. Gliomas, known for their aggressive and infiltrative nature, demand innovative therapeutic strategies for improved patient outcomes. Our study bridges a critical gap by examining the interplay between non-apoptotic cell death and immunotherapy response in gliomas. Through comprehensive analysis of ten diverse glioma datasets, we developed a unique death enrichment score and identified ITGB2 as a significant risk marker...
March 15, 2024: Environmental Toxicology
https://read.qxmd.com/read/38487720/case-report-from-sequence-to-solution-tailoring-treatment-for-transformed-follicular-lymphoma-dlbcl-through-next-generation-sequencing-study
#28
Antonin Bouroumeau, Sarah Perdikis-Prati, Noémie Lang
Immune checkpoint blockade (ICB) has indeed transformed the outlook for many advanced-stage solid tumors, yet its effectiveness in hematological malignancies has been particularly limited, with success predominantly demonstrated in classical Hodgkin lymphoma (cHL) and immune-privilege subtypes of non-Hodgkin lymphoma (NHL). In this report, we present an impactful case of a 71-year-old man grappling with refractory follicular lymphoma (rFL) that had progressed to a high-grade lymphoma, leaving no conventional treatment options on the table...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38487163/ultrasound-combined-with-microbubble-mediated-immunotherapy-for-tumor-microenvironment
#29
REVIEW
Yunfeng Wu, Jiajia Li, Linfeng Shu, Zhaoyu Tian, Siru Wu, Zuohui Wu
The tumor microenvironment (TME) plays an important role in dynamically regulating the progress of cancer and influencing the therapeutic results. Targeting the tumor microenvironment is a promising cancer treatment method in recent years. The importance of tumor immune microenvironment regulation by ultrasound combined with microbubbles is now widely recognized. Ultrasound and microbubbles work together to induce antigen release of tumor cell through mechanical or thermal effects, promoting antigen presentation and T cells' recognition and killing of tumor cells, and improve tumor immunosuppression microenvironment, which will be a breakthrough in improving traditional treatment problems such as immune checkpoint blocking (ICB) and himeric antigen receptor (CAR)-T cell therapy...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38486982/epigenetic-modification-in-liver-fibrosis-promising-therapeutic-direction-with-significant-challenges-ahead
#30
REVIEW
Runping Liu, Yajing Li, Qi Zheng, Mingning Ding, Huiping Zhou, Xiaojiaoyang Li
Liver fibrosis, characterized by scar tissue formation, can ultimately result in liver failure. It's a major cause of morbidity and mortality globally, often associated with chronic liver diseases like hepatitis or alcoholic and non-alcoholic fatty liver diseases. However, current treatment options are limited, highlighting the urgent need for the development of new therapies. As a reversible regulatory mechanism, epigenetic modification is implicated in many biological processes, including liver fibrosis. Exploring the epigenetic mechanisms involved in liver fibrosis could provide valuable insights into developing new treatments for chronic liver diseases, although the current evidence is still controversial...
March 2024: Acta Pharmaceutica Sinica. B
https://read.qxmd.com/read/38486748/the-clinical-impact-of-mrna-therapeutics-in-the-treatment-of-cancers-infections-genetic-disorders-and-autoimmune-diseases
#31
REVIEW
Roham Deyhimfar, Mehrnaz Izady, Mohammadreza Shoghi, Mohammad Hossein Kazazi, Zahra Fakhraei Ghazvini, Hojjatollah Nazari, Zahra Fekrirad, Ehsan Arefian
mRNA-based therapeutics have revolutionized medicine and the pharmaceutical industry. The recent progress in the optimization and formulation of mRNAs has led to the development of a new therapeutic platform with a broad range of applications. With a growing body of evidence supporting the use of mRNA-based drugs for precision medicine and personalized treatments, including cancer immunotherapy, genetic disorders, and autoimmune diseases, this emerging technology offers a rapidly expanding category of therapeutic options...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38486383/a-review-on-novel-therapeutic-modalities-and-evidence-based-drug-treatments-against-allergic-rhinitis
#32
JOURNAL ARTICLE
Bhupendra Sharma, Rohitas Deshmukh
Allergic rhinitis (AR) is an IgE-mediated atopic disease that occurs due to inhaled antigens in the immediate phase. Misdiagnosis, insufficient treatment, or no treatment at all are frequent problems associated with the widespread condition known as chronic allergic rhinitis. AR symptoms include runny, itchy, stuffy, and sneezing noses. Asthma and nasal polyps, for example, sometimes occur simultaneously in patients. In order for people living with AR to be as comfortable and productive as possible, treatment should center on reducing their symptoms...
March 14, 2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38486188/hiv-protease-resistance-mutations-in-patients-receiving-second-line-antiretroviral-therapy-in-libreville-gabon
#33
JOURNAL ARTICLE
Guy Francis Nzengui-Nzengui, Gaël Mourembou, Hervé M'boyis-Kamdem, Ayawa Claudine Kombila-Koumavor, Angélique Ndjoyi-Mbiguino
INTRODUCTION: In 2022, the WHO reported that 29.8 million people around the world were living with HIV (PLHIV) and receiving antiretroviral treatment (ART), including 25‌ 375 people in Gabon (54% of all those living with HIV in the country). The literature reports a frequency of therapeutic failure with first-line antiretrovirals (ARVs) of between 20% and 82%. Unfortunately, data relating to the failure of second-line ARVs are scarce in Gabon. This study aims to determine the profiles of HIV drug resistance mutations related to protease inhibitors in Gabon...
March 14, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38485676/biofilm-formation-in-mycobacterial-genus-mechanism-of-biofilm-formation-and-anti-mycobacterial-biofilm-agents
#34
JOURNAL ARTICLE
Sina Nasrollahian, Hassan Pourmoshtagh, Sahar Sabour, Nahal Hadi, Taher Azimi, Saeed Soleiman-Meigooni
Mycobacterium tuberculosis, Mycobacterium leprae, and non-tuberculous mycobacteria (NTM) are among the most significant human pathogens within the Mycobacterium genus. These pathogens can infect people who come into contact with biomaterials or have chronic illnesses. A characteristic pathogenic trait of mycobacteria is the development of biofilms, which involves several molecules, such as the GroEL1 chaperone, glycopeptidolipids, and shorter-chain mycolic acids. Bacterial behavior is influenced by nutrients, ions, and carbon sources, which also play a regulatory role in biofilm development...
March 11, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38485558/enterocolitis-and-other-immunotherapy-and-targeted-therapy-related-gastrointestinal-manifestations-a-review-for-gastroenterologist
#35
REVIEW
O Gómez Escudero
New oncologic treatments, particularly immunotherapy (IT), have revolutionized the treatment of advanced-stage malignant tumors. Immune checkpoint inhibitors are the main form of IT and act by increasing T cell activity and the organism's immune response against neoplastic cells. Targeted therapy is another form of IT that acts by inhibiting oncogenes or inflammation signaling and tumor angiogenesis pathways. However, these mechanisms of tumor destruction can interfere with the host's immune self-tolerance or with the mechanisms of epithelial tissue repair and predispose to immune system-mediated adverse events that can affect multiple organs, including the digestive tract...
March 13, 2024: Revista de Gastroenterología de México
https://read.qxmd.com/read/38485551/targeted-agents-in-esophagogastric-cancer-beyond-human-epidermal-growth-factor-receptor-2
#36
REVIEW
Eric Mehlhaff, Devon Miller, Johnathan E Ebben, Oleksii Dobrzhanskyi, Nataliya V Uboha
Gastroesophageal cancers are highly diverse tumors in terms of their anatomic and molecular characteristics, making drug development challenging. Recent advancements in understanding the molecular profiles of these cancers have led to the identification of several new biomarkers. Ongoing clinical trials are investigating new targeted agents with promising results. CLDN18.2 has emerged as a biomarker with established activity of associated targeted therapies. Other targeted agents, such as bemarituzumab and DKN-01, are under active investigation...
March 13, 2024: Hematology/oncology Clinics of North America
https://read.qxmd.com/read/38485506/potential-therapeutic-role-of-spermine-via-rac1-in-osteoporosis-insights-from-zebrafish-and-mice
#37
JOURNAL ARTICLE
Rui-Xue Jiang, Nan Hu, Yu-Wei Deng, Long-Wei Hu, Hao Gu, Nan Luo, Jin Wen, Xin-Quan Jiang
Osteoporosis is a prevalent metabolic bone disease. While drug therapy is essential to prevent bone loss in osteoporotic patients, current treatments are limited by side effects and high costs, necessitating the development of more effective and safer targeted therapies. Utilizing a zebrafish ( Danio rerio ) larval model of osteoporosis, we explored the influence of the metabolite spermine on bone homeostasis. Results showed that spermine exhibited dual activity in osteoporotic zebrafish larvae by increasing bone formation and decreasing bone resorption...
March 18, 2024: Zoological Research
https://read.qxmd.com/read/38485412/new-treatments-for-children-with-achondroplasia
#38
REVIEW
Ravi Savarirayan, Julie Hoover-Fong, Patrick Yap, Svein O Fredwall
Achondroplasia is the most common form of dwarfism in humans, caused by a common pathogenic variant in the gene encoding fibroblast growth factor receptor 3, FGFR3, which impairs the process of endochondral ossification of the growing skeleton. In this Review, we outline the clinical and genetic hallmarks of achondroplasia and related FGFR3 conditions, the natural history and impact of achondroplasia over a patient's lifespan, and diagnosis and management options. We then focus on the new and emerging drug therapies that target the underlying pathogenesis of this condition...
April 2024: Lancet Child & Adolescent Health
https://read.qxmd.com/read/38485221/engineered-microorganisms-for-advancing-tumor-therapy
#39
REVIEW
Jinxuan Jia, Xiaocheng Wang, Xiang Lin, Yuanjin Zhao
Engineered microorganisms have attracted significant interest as a unique therapeutic platform in tumor treatment. Compared with conventional cancer treatment strategies, engineering microorganism-based systems provide various distinct advantages, such as the intrinsic capability in targeting tumors, their inherent immunogenicity, in situ production of antitumor agents, and multiple synergistic functions to fight against tumors. Herein, we thoroughly review the design, preparation, and application of the engineered microorganisms for advanced tumor therapy...
March 14, 2024: Advanced Materials
https://read.qxmd.com/read/38484756/optimised-prevention-of-postnatal-hiv-transmission-in-zambia-and-burkina-faso-promise-epi-a-phase-3-open-label-randomised-controlled-trial
#40
JOURNAL ARTICLE
Chipepo Kankasa, Anaïs Mennecier, Beninwendé L D Sakana, Jean-Pierre Molès, Mwiya Mwiya, Catherine Chunda-Liyoka, Morgana D'Ottavi, Souleymane Tassembedo, Maria M Wilfred-Tonga, Paulin Fao, David Rutagwera, Beauty Matoka, Dramane Kania, Ousmane A Taofiki, Thorkild Tylleskär, Philippe Van de Perre, Nicolas Nagot
BACKGROUND: Transmission through breastfeeding accounts for more than half of the unacceptably high number of new paediatric HIV infections worldwide. We hypothesised that, in addition to maternal antiretroviral therapy (ART), extended postnatal prophylaxis with lamivudine, guided by point-of-care assays for maternal viral load, could reduce postnatal transmission. METHODS: We did a phase 3, open-label, randomised controlled trial at four health-care facilities in Zambia and four health-care facilities in Burkina Faso...
March 11, 2024: Lancet
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