keyword
https://read.qxmd.com/read/38493359/comprehensive-phenotypic-characterization-of-an-allelic-series-of-zebrafish-models-of-neb-related-nemaline-myopathy
#1
JOURNAL ARTICLE
Lacramioara Fabian, Esmat Karimi, Gerrie P Farman, Jochen Gohlke, Coen A C Ottenheijm, Hendrikus L Granzier, James J Dowling
Nemaline myopathy (NM) is a rare congenital neuromuscular disorder characterized by muscle weakness and hypotonia, slow gross motor development, and decreased respiratory function. Mutations in at least twelve genes, all of each encode proteins that are either components of the muscle thin filament or regulate its length and stability, have been associated with NM. Mutations in Nebulin (NEB), a giant filamentous protein localized in the sarcomere, account for more than 50% of NM cases. At present, there remains a lack of understanding of whether NEB genotype influences nebulin function and NM-patient phenotypes...
March 17, 2024: Human Molecular Genetics
https://read.qxmd.com/read/38493151/gli1-mediated-tumor-cell-derived-bfgf-promotes-tumor-angiogenesis-and-pericyte-coverage-in-non-small-cell-lung-cancer
#2
JOURNAL ARTICLE
Xueping Lei, Zhan Li, Manting Huang, Lijuan Huang, Yong Huang, Sha Lv, Weisong Zhang, Zhuowen Chen, Yuanyu Ke, Songpei Li, Jingfei Chen, Xiangyu Yang, Qiudi Deng, Junshan Liu, Xiyong Yu
BACKGROUND: Tumor angiogenesis inhibitors have been applied for non-small cell lung cancer (NSCLC) therapy. However, the drug resistance hinders their further development. Intercellular crosstalk between lung cancer cells and vascular cells was crucial for anti-angiogenenic resistance (AAD). However, the understanding of this crosstalk is still rudimentary. Our previous study showed that Glioma-associated oncogene 1 (Gli1) is a driver of NSCLC metastasis, but its role in lung cancer cell-vascular cell crosstalk remains unclear...
March 16, 2024: Journal of Experimental & Clinical Cancer Research: CR
https://read.qxmd.com/read/38493007/revolutionising-healing-gene-editing-s-breakthrough-against-sickle-cell-disease
#3
REVIEW
Marija Dimitrievska, Dravie Bansal, Marta Vitale, John Strouboulis, Annarita Miccio, Kypros H Nicolaides, Sara El Hoss, Panicos Shangaris, Joanna Jacków-Malinowska
Recent advancements in gene editing illuminate new potential therapeutic approaches for Sickle Cell Disease (SCD), a debilitating monogenic disorder caused by a point mutation in the β-globin gene. Despite the availability of several FDA-approved medications for symptomatic relief, allogeneic hematopoietic stem cell transplantation (HSCT) remains the sole curative option, underscoring a persistent need for novel treatments. This review delves into the growing field of gene editing, particularly the extensive research focused on curing haemoglobinopathies like SCD...
March 7, 2024: Blood Reviews
https://read.qxmd.com/read/38493003/clinical-impact-of-vancomycin-mic-on-outcomes-in-patients-with-coagulase-negative-staphylococcal-bacteremia
#4
JOURNAL ARTICLE
Wade Wheat, Brenda Simiyu, Gabriela Andonie, Lillian Bellfi
PURPOSE: Coagulase-negative staphylococci (CoNS) are Gram-positive organisms that are a known component of normal skin flora and the most common cause of nosocomial bacteremia. For CoNS species, the vancomycin MIC breakpoint for susceptibility set by the Clinical and Laboratory Standards Institute is ≤4 µg/mL. There has been published reports of vancomycin heteroresistance in CoNS with vancomycin MICs of 2 to 4 µg/mL. The aim of this retrospective cohort analysis was to assess the clinical impact of vancomycin MICs <2 µg/mL versus ≥2 µg/mL in adult patients with CoNS bloodstream infections...
March 15, 2024: Clinical Therapeutics
https://read.qxmd.com/read/38492616/a-review-regarding-the-article-the-cardioprotective-potential-of-sodium-glucose-cotransporter-2-inhibitors-in-breast-cancer-therapy-related-cardiac-dysfunction-a-systematic-review
#5
REVIEW
Gang Zhao, Lei Wang, Hong Fang, Liwei Wang
Breast cancer is one of the most common types of cancer, representing 15% of all new cancer cases in the United States. Approximately 12.4% of all women will be diagnosed with breast cancer during their lifetime. In the past decades, a decrease in cancer-related mortality is evident as a result of early screening and improved therapeutic options. Nonetheless, breast cancer survivors face long-term treatment side effects, with cardiotoxicity being the most significant one, which lead to increased morbidity and mortality...
March 14, 2024: Current Problems in Cardiology
https://read.qxmd.com/read/38492541/inhibition-of-cancer-cells-by-quinoline-based-compounds-a-review-with-mechanistic-insights
#6
REVIEW
Anjali Saxena, Suman Majee, Devalina Ray, Biswajit Saha
This article includes a thorough examination of the inhibitory potential of quinoline-based drugs on cancer cells, as well as an explanation of their modes of action. Quinoline derivatives, due to their various chemical structures and biological activity, have emerged as interesting candidates in the search for new anticancer drugs. The review paper delves into the numerous effects of quinoline-based chemicals in cancer progression, including apoptosis induction, cell cycle modification, and interference with tumor-growth signaling pathways...
March 12, 2024: Bioorganic & Medicinal Chemistry
https://read.qxmd.com/read/38492477/on-off-based-synergetic-plasmonic-photothermal-drug-release-approach-through-core-satellite-like-mussel-inspired-polydopamine-nanoparticles
#7
JOURNAL ARTICLE
Hakan Erdoğan, Burcu Karayavuz, Merve Güdül Bacanlı, Özgür Eşim, Meral Sarper, Sevde Altuntaş, Onur Erdem, Yalçın Özkan
One of the studies on new drug delivery and release systems that has increased in recent years is the study using plasmonic nanoparticles. In this study, polydopamine nanoparticles (PDOP NPs), which contribute to photothermal drug release by near infrared radiation (NIR), were decorated with gold nanoparticles (AuNPs) to utilize their plasmonic properties, and a core-satellite-like system was formed. With this approach, epirubicin (EPI)-loaded PDOP NPs were prepared by utilizing the plasmonic properties of AuNPs...
March 12, 2024: Journal of Photochemistry and Photobiology. B, Biology
https://read.qxmd.com/read/38492339/protective-effect-of-carbon-dots-as-antioxidants-on-intestinal-inflammation-by-regulating-oxidative-stress-and-gut-microbiota-in-nematodes-and-mouse-models
#8
JOURNAL ARTICLE
Nannan Peng, Jingmin Wang, Haimei Zhu, Ziyue Liu, Jiayi Ren, Wenjing Li, Yongzhong Wang
Inflammatory bowel disease (IBD) is a recurrent chronic colitis disease with increasing incidence and prevalence year by year. The single efficacy and significant side effects of traditional IBD treatment drugs have promoted the flourishing development of new drugs. Inspired by many health benefits of carbon dots (CDs) based nanomedicine in biomedical applications, a metal-free carbon dots (CP-CDs) was synthesized from citric acid and polyethylene polyamine to treat colitis. Oxidative stress tests at the cellular and nematode levels demonstrated CP-CDs have good antioxidant effects, while the toxicity of CP-CDs to cells and nematodes is low...
March 15, 2024: International Immunopharmacology
https://read.qxmd.com/read/38491538/a-case-report-of-drug-interaction-between-co-packaged-nirmatrelvir-ritonavir-and-tacrolimus-causing-hyponatremia-in-a-lung-transplant-recipient
#9
JOURNAL ARTICLE
Chien-Ming Lo, Wei-Hsun Chen, Meng-Yun Tsai, Hung-I Lu, Yu-Hsin Hsiao, Kai-Hao Chuang, Yu Chen, Hsuan-Feng Wu, Kuo-Tung Huang, Yi-Hsi Wang
BACKGROUND: Coronavirus disease 2019 (COVID-19) infection in lung transplant recipients can be lethal owing to the use of immunosuppressants. Antiviral agents may be administered to these patients. Co-packaged nirmatrelvir-ritonavir is a new agent currently being used in combination. CASE PRESENTATION: In this report, we present a case of a 64-year-old woman, a lung transplant recipient, who experienced hyponatremia and showed a high serum tacrolimus concentration following the administration of the co-packaged nirmatrelvir-ritonavir combination...
March 15, 2024: Journal of Cardiothoracic Surgery
https://read.qxmd.com/read/38491394/designer-cell-therapy-for-tissue-regeneration
#10
REVIEW
Noyuri Zama, Satoshi Toda
Cancer cell therapy, particularly chimeric antigen receptor (CAR) T-cell therapy for blood cancers, has emerged as a powerful new modality for cancer treatment. Therapeutic cells differ significantly from conventional drugs, such as small molecules and biologics, as they possess cellular information processing abilities to recognize and respond to abnormalities in the body. This capability enables the targeted delivery of therapeutic factors to specific locations and times. Various types of designer cells have been developed and tested to overcome the shortcomings of CAR T cells and expand their functions in the treatment of solid tumors...
March 15, 2024: Inflammation and Regeneration
https://read.qxmd.com/read/38490927/port-a-randomized-cross-over-phase-2-study-of-melflufen-peripheral-versus-central-intravenous-administration-in-patients-with-relapsed-refractory-multiple-myeloma
#11
JOURNAL ARTICLE
Ludek Pour, Ilina Micheva, Ganna Usenko, Gabor Mikala, Tamas Masszi, Kameliya Simeonova, Marcus Thuresson, Gunilla Huledal, Stefan Norin, Nicolaas A Bakker, Jiri Minarik
BACKGROUND: Melflufen, a first-in-class alkylating peptide-drug conjugate, rapidly enters tumor cells and metabolizes to melphalan. In previous studies, melflufen was administered via central venous catheter (CVC). However, administration by peripheral venous catheter (PVC) may be preferable. PATIENTS AND METHODS: PORT was a two-period, phase 2 crossover study of CVC versus PVC melflufen administration in patients with relapsed/refractory multiple myeloma. Adults with ≥ 2 prior therapies refractory to/intolerant of an immunomodulatory drug and a proteasome inhibitor were randomized 1:1 to weekly oral dexamethasone plus melflufen (40 mg) via CVC or PVC infusion on day 1 of 28-day cycle 1...
February 23, 2024: Clinical Lymphoma, Myeloma & Leukemia
https://read.qxmd.com/read/38490542/evaluation-of-the-protective-bioactivity-and-molecular-mechanism-verification-of-lactoferrin-in-an-alzheimer-s-mouse-model-with-ulcerative-enteritis
#12
JOURNAL ARTICLE
Longyi Ran, Jiarui Shi, Yinan Lin, Chenlin Xu, Zhengkun Han, Sen Tian, Xiaoyang Qin, Qinjin Li, Taiyu Zhang, Huiying Li, Yu Zhang
The development of new drug therapies for Alzheimer's disease (AD) is an important research topic today, but the pathogenesis of AD has not been thoroughly studied, and there are still several shortcomings in existing drug therapies. Therefore, this study aims to explore the molecular mechanism of lactoferrin in the treatments of AD and ulcerative colitis (UC) which are susceptible to AD, starting from the principle of "one drug, two diseases, and the same treatment." This study used pathological staining and specific indicators staining to preliminarily evaluate the interventions of lactoferrin on UC injury and AD progression...
March 13, 2024: Journal of Dairy Science
https://read.qxmd.com/read/38490480/potential-risk-factors-for-early-acute-kidney-injury-in-patients-treated-with-vancomycin
#13
JOURNAL ARTICLE
Aiju Endo, Kazumi Hanawa, Daiki Asakawa, Taiki Ishibe, Yu Nakane, Kaori Matsumoto, Yukihiro Hamada
PURPOSE: The acute kidney injury (AKI) onset owing to vancomycin (VCM) is reported that depend on the area under the blood concentration-time curve (AUC) and occur comparison early phase (early AKI). This study aimed to investigate the occurrence of early AKI in patients treated with VCM and new indicators to avoid early AKI. METHODS: Adult patients who received VCM treatment for more than 4 days and whose trough values measured at least once on or after day 4 and serum creatinine before day 7 from the initiation of VCM administration between August 2021 and September 2022 at the Yamanashi Prefectural Central Hospital were enrolled...
March 13, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/38490453/medication-associated-orbital-inflammation-a-systematic-review
#14
REVIEW
Terence Ang, Viraj Chaggar, Jessica Y Tong, Dinesh Selva
We performed a comprehensive systematic review to identify medication-associated orbital inflammation and to characterize its clinico-radiological features. We reviewed English-language articles describing medication-associated orbital inflammation (i.e., orbital myositis, dacryoadenitis and orbital fat) published to June 2023. Isolated inflammation of the intraocular structures or globe alone (i.e. uveitis), scleritis, optic neuritis and peri-neuritis) were excluded. In medication-associated orbital inflammation, the extraocular muscles are preferentially affected, occurring in isolation or in combination with other orbital and/or intraocular structures...
March 13, 2024: Survey of Ophthalmology
https://read.qxmd.com/read/38490403/assessment-of-chitosan-coated-zinc-cobalt-ferrite-nanoparticle-as-a-multifunctional-theranostic-platform-facilitating-ph-sensitive-drug-delivery-and-oct-image-contrast-enhancement
#15
JOURNAL ARTICLE
Dhruba Dhar, Subhadip Ghosh, Sayan Mukherjee, Santanu Dhara, Jyotirmoy Chatterjee, Soumen Das
Colorectal cancer (CC) is one of the most predominant malignancies in the world, with the current treatment regimen consisting of surgery, radiation therapy, and chemotherapy. Chemotherapeutic drugs, such as 5-fluorouracil (5-FU), have gained popularity as first-line antineoplastic agents against CC but have several drawbacks, including variable absorption through the gastrointestinal tract, inconsistent liver metabolism, short half-life, toxicological reactions in several organ systems, and others. Therefore, herein, we develop chitosan-coated zinc-substituted cobalt ferrite nanoparticles (CZCFNPs) for the pH-sensitive (triggered by chitosan degradation within acidic organelles of cells) and sustained delivery of 5-FU in CC cells in vitro...
March 13, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38490170/bioorthogonal-in-situ-polymerization-of-dendritic-agents-for-hijacking-lysosomes-and-enhancing-antigen-presentation-in-cancer-cells
#16
JOURNAL ARTICLE
Dan Zhong, Xingyu Hou, Dayi Pan, Zhiqian Li, Qiyong Gong, Kui Luo
A low generation lysine dendrimer, SPr-G2, responds to intracellular glutathione to initiate bioorthogonal in situ polymerization, resulting in the formation of large assemblies in mouse breast cancer cells. The intracellular large assemblies of SPr-G2 can interact with lysosomes to induce lysosome expansion and enhance lysosomal membrane permeabilization (LMP), leading to major histocompatibility complex class I (MHC-I) upregulation on tumor cell surfaces and ultimately tumor cell death. Moreover, the use of the SPr-G2 dendrimer to conjugate the chemotherapeutic drug, camptothecin (CPT), can boost the therapeutic potency of CPT...
March 15, 2024: Advanced Materials
https://read.qxmd.com/read/38490155/cynaroside-improved-depressive-like-behavior-in-cums-mice-by-suppressing-microglial-inflammation-and-ferroptosis
#17
JOURNAL ARTICLE
Yiwei Zhou, Yuhan Huang, Wei Ye, Zijie Chen, Zhengzhong Yuan
Depression is a common mental health disorder, and in recent years, the incidence of various forms of depression has been on the rise. Most medications for depression are highly dependency-inducing and can lead to relapse upon discontinuation. Therefore, novel treatment modalities and therapeutic targets are urgently required. Traditional Chinese medicine (TCM) offers advantages in the treatment of depression owing to its multi-target, multi-dimensional approach that addresses the root cause of depression by regulating organ functions and balancing Yin and Yang, with minimal side effects...
March 14, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38490040/enhanced-cellular-internalization-of-near-infrared-fluorescent-single-walled-carbon-nanotubes-facilitated-by-a-transfection-reagent
#18
JOURNAL ARTICLE
Naamah Levin, Adi Hendler-Neumark, Dotan Kamber, Gili Bisker
Functionalized single-walled carbon nanotubes (SWCNTs) hold immense potential for diverse biomedical applications due to their biocompatibility and optical properties, including near-infrared fluorescence. Specifically, SWCNTs have been utilized to target cells as a vehicle for drug delivery and gene therapy, and as sensors for various intracellular biomarkers. While the main internalization route of SWCNTs into cells is endocytosis, methods for enhancing the cellular uptake of SWCNTs are of great importance...
March 6, 2024: Journal of Colloid and Interface Science
https://read.qxmd.com/read/38489696/network-pharmacology-and-molecular-docking-to-explore-the-mechanism-of-a-clinical-proved-recipe-for-external-use-of-clearing-heat-and-removing-dampness-in-the-treatment-of-immune-related-cutaneous-adverse-events
#19
JOURNAL ARTICLE
Shuyi Chen, Rui Yu, Fangmin Zhao, Lin Sun, Yudan Yin, Gaochenxi Zhang, Qunwei Chen, Qijin Shu
Immune-related cutaneous adverse events (ircAEs) will undermine the patients' quality of lives, and interrupt the antitumor therapy. A clinical proved recipe for external use of clearing heat and removing dampness (Qing-Re-Li-Shi Formula, hereinafter referred to as "QRLSF") is beneficial to the treatment of ircAEs in clinical practice. Our study will elucidate the mechanism of QRLSF against ircAEs based on network pharmacology and molecular docking. The active components and corresponding targets of QRLSF were collected through traditional Chinese medicine systems pharmacology database...
March 15, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38489405/research-progress-on-the-mechanism-of-common-inflammatory-pathways-in-the-pathogenesis-and-development-of-lymphoma
#20
REVIEW
Aorong Shi, Fen Yun, Lin Shi, Xia Liu, Yongfeng Jia
In recent years, the incidence and mortality rates of lymphoma have gradually increased worldwide. Tumorigenesis and drug resistance are closely related to intracellular inflammatory pathways in lymphoma. Therefore, understanding the biological role of inflammatory pathways and their abnormal activation in relation to the development of lymphoma and their selective modulation may open new avenues for targeted therapy of lymphoma. The biological functions of inflammatory pathways are extensive, and they are central hubs for regulating inflammatory responses, immune responses, and the tumour immune microenvironment...
December 2024: Annals of Medicine
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