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Gait instability

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https://www.readbyqxmd.com/read/29143300/effect-of-restraining-the-base-of-support-on-the-other-biomechanical-features-in-patients-with-cerebellar-ataxia
#1
C Conte, Mariano Serrao, L Cuius, A Ranavolo, S Conforto, F Pierelli, L Padua
This study aimed to analyze the biomechanical consequences of reducing the base of support in patients with ataxia. Specifically, we evaluated the spatio-temporal parameters, upper- and lower-body kinematics, muscle co-activation, and energy recovery and expenditure. The gaits of 13 patients were recorded using a motion analysis system in unperturbed and perturbed walking conditions. In the latter condition, patients had to walk using the same step width and speed of healthy controls. The perturbed walking condition featured reduced gait speed, step length, hip and knee range of motion, and energy recovery and increased double support duration, gait variability, trunk oscillation, and ankle joint muscle co-activation...
November 15, 2017: Cerebellum
https://www.readbyqxmd.com/read/29137084/vertebral-column-decortication-for-the-management-of-sharp-angular-spinal-deformity-in-pott-disease-case-report
#2
Hong-Tao Hu, Feng-Yu Liu, Jin-He Yu, Liang Ren, Zhen-Fang Gu, Xian-Ze Sun
RATIONALE: Extremely sharp angular spinal deformity of healed tuberculosis can be corrected by vertebral column resection (VCR). However, the VCR techniques have many limitations including spinal column instability, greater blood loss, and greater risk of neurologic deficit. PATIENT CONCERNS: We described a new spinal osteotomy technique to collect sharp angular spinal deformity in Pott disease. A 52-year-old woman presented with back pain and gait imbalance. DIAGNOSIS: The kyphosis of healed tuberculosis was diagnosed based on history and imaging examinations...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29125433/a-points-based-algorithm-for-prognosticating-clinical-outcome-of-chiari-malformation-type-i-with-syringomyelia-results-from-a-predictive-model-analysis-of-82-surgically-managed-adult-patients
#3
Sumit Thakar, Laxminadh Sivaraju, Kuruthukulangara S Jacob, Aditya Atal Arun, Saritha Aryan, Dilip Mohan, Narayanam Anantha Sai Kiran, Alangar S Hegde
OBJECTIVE Although various predictors of postoperative outcome have been previously identified in patients with Chiari malformation Type I (CMI) with syringomyelia, there is no known algorithm for predicting a multifactorial outcome measure in this widely studied disorder. Using one of the largest preoperative variable arrays used so far in CMI research, the authors attempted to generate a formula for predicting postoperative outcome. METHODS Data from the clinical records of 82 symptomatic adult patients with CMI and altered hindbrain CSF flow who were managed with foramen magnum decompression, C-1 laminectomy, and duraplasty over an 8-year period were collected and analyzed...
November 10, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29124285/kinematics-and-arthrokinematics-in-the-chronic-acl-deficient-knee-are-altered-even-in-the-absence-of-instability-symptoms
#4
Chen Yang, Yasutaka Tashiro, Andrew Lynch, Freddie Fu, William Anderst
PURPOSE: To analyze the in vivo kinematics and arthrokinematics of chronic ACL-deficient (ACL-D) and unaffected contralateral knees during level walking and downhill running using dynamic biplane radiography. It was hypothesized that ACL-D knees would demonstrate increased anterior translation and internal rotation, and that ACL-deficiency would alter the tibiofemoral contact paths in comparison to the unaffected contralateral side. METHODS: Eight participants with unilateral chronic ACL-D without instability symptoms were recruited...
November 9, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29116827/frontal-plane-variability-in-foot-orientation-during-fatiguing-running-exercise-in-individuals-with-chronic-ankle-instability
#5
Denise McGrath, Matthew Patterson, Ulrik McCarthy Persson, Brian Caulfield
CONTEXT:   Researchers have reported increased variability in frontal-plane movement at the ankle during jumping in individuals with chronic ankle instability (CAI), which may increase their risk of recurrent ankle sprain. It is not known if this behavior is present during running gait or how fatigue affects the amount of frontal-plane-movement variability in individuals with CAI. OBJECTIVE:   To investigate the amount of roll-angle variability at the foot during a fatiguing exercise protocol in participants with CAI...
November 8, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/29100597/determinants-of-gait-stability-while-walking-on-a-treadmill-a-machine-learning-approach
#6
Fabienne Reynard, Philippe Terrier
Dynamic balance in human locomotion can be assessed through the local dynamic stability (LDS) method. Whereas gait LDS has been used successfully in many settings and applications, little is known about its sensitivity to individual characteristics of healthy adults. Therefore, we reanalyzed a large dataset of accelerometric data measured for 100 healthy adults from 20 to 70 years of age performing 10 min treadmill walking. We sought to assess the extent to which the variations of age, body mass and height, sex, and preferred walking speed (PWS) could influence gait LDS...
October 25, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29095748/central-control-of-eye-movements
#7
Jonathan J D Baird-Gunning, Christian J Lueck
PURPOSE OF REVIEW: Eye-movement research continues to provide an excellent tool for understanding the central control of motor function, both in health and disease. This article reviews recent findings in relation to saccadic eye movements, particularly antisaccades and microsaccades, with particular emphasis on the control of inaction, something which has recently become topical. RECENT FINDINGS: Microsaccades are under the control of the cerebral cortex, particularly the frontal and parietal eye fields...
November 1, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29095326/bismuth-subgallate-toxicity-in-the-age-of-online-supplement-use
#8
Paul Sampognaro, Kathy T Vo, Megan Richie, Paul D Blanc, Kevin Keenan
INTRODUCTION: Bismuth salts have been used to treat gastroenterological disorders and are readily available over-the-counter and via the internet. Even though generally considered safe, bismuth compounds can cause a syndrome of subacute, progressive encephalopathy when taken in large quantities. CASE REPORT: We present the case of woman who developed progressive encephalopathy, aphasia, myoclonus, and gait instability after chronically ingesting large amounts of bismuth subgallate purchased from a major online marketing website to control symptoms of irritable bowel syndrome...
November 2017: Neurologist
https://www.readbyqxmd.com/read/29089992/corticoreticular-tract-lesion-in-children-with-developmental-delay-presenting-with-gait-dysfunction-and-trunk-instability
#9
Yong Min Kwon, Jessica Rose, Ae Ryoung Kim, Su Min Son
The corticoreticular tract (CRT) is known to be involved in walking and postural control. Using diffusion tensor tractography (DTT), we investigated the relationship between the CRT and gait dysfunction, including trunk instability, in pediatric patients. Thirty patients with delayed development and 15 age-matched, typically-developed (TD) children were recruited. Fifteen patients with gait dysfunction (bilateral trunk instability) were included in the group A, and the other 15 patients with gait dysfunction (unilateral trunk instability) were included in the group B...
September 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29063605/disturbance-of-verticality-perception-and-postural-dysfunction-in-parkinson-s-disease
#10
K A Schindlbeck, W Naumann, A Maier, F Ehlen, F Marzinzik, F Klostermann
OBJECTIVES: Verticality perception is known to be abnormal in Parkinson's disease (PD), but in which stage respective dysfunctions arise and how they relate to postural disorders remains to be settled. These issues were studied with respect to different dimensions of the subjective visual vertical (SVV) in relation to clinical parameters of postural control. MATERIALS & METHODS: All participants had to orientate a luminous line at random planar orientations to a strictly vertical position using an automated operator system...
October 23, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29046205/-clinical-phenotype-and-genetic-analysis-of-med13l-syndrome
#11
Qing-Jie Meng, Xue-Lian He, Han Xiao, Qian Xia, Bo Bi, Yun Xiang
A boy aged 4 years and 2 months was found to have delayed language and motor development, instability of gait, poor eye contact, stereotyped behavior, and seizure at the age of 3 years. Physical examination showed special facial features, including plagiocephaly, blepharoptosis, wide nasal bridge, down-turned mouth corners at both sides, and low-set ears. There were only two knuckles at the little finger of the left hand. The anteroposterior and lateral films of the spine showed scoliosis; echocardiography showed ventricular septal defect; the Gesell Developmental Scale showed delayed language development and moderate intellectual disability; there were no abnormalities in the karyotype; genome-wide SNP arrays found a duplication in 12q24...
October 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29031193/the-retention-of-lacosamide-in-patients-with-epilepsy-and-intellectual-disability-in-three-specialised-institutions
#12
J Brenner, H J M Majoie, S van Beek, J A Carpay
PURPOSE: We describe the effectiveness of lacosamide as adjunctive therapy in patients with epilepsy and an intellectual disability. This information is relevant, as few data exist pertaining to this population with a high prevalence of (intractable) epilepsy. METHODS: We performed a retrospective study in three specialised institutions. Inclusion criteria were (1) focal onset or symptomatic generalized (2) therapy-resistant epilepsy, (3) intellectual disability and (4) residence in a care-facility for people with intellectual disabilities (PWID)...
October 3, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29027544/long-term-effects-of-exercise-and-physical-therapy-in-people-with-parkinson-disease
#13
REVIEW
Margaret K Mak, Irene S Wong-Yu, Xia Shen, Chloe L Chung
Parkinson disease (PD) is a progressive, neurodegenerative movement disorder with symptoms reflecting various impairments and functional limitations, such as postural instability, gait disturbance, immobility and falls. In addition to pharmacological and surgical management of PD, exercise and physical therapy interventions are also being actively researched. This Review provides an overview of the effects of PD on physical activity - including muscle weakness, reduced aerobic capacity, gait impairment, balance disorders and falls...
November 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29026131/mechanical-stress-induces-elastic-fibre-disruption-and-cartilage-matrix-increase-in-ligamentum-flavum
#14
Kazunori Hayashi, Akinobu Suzuki, Sayed Abdullah Ahmadi, Hidetomi Terai, Kentaro Yamada, Masatoshi Hoshino, Hiromitsu Toyoda, Shinji Takahashi, Koji Tamai, Shoichiro Ohyama, Akgar Javid, Mohammad Suhrab Rahmani, Maruf Mohammad Hasib, Hiroaki Nakamura
Lumbar spinal stenosis (LSS) is one of the most frequent causes of low back pain and gait disturbance in the elderly. Ligamentum flavum (LF) hypertrophy is the main pathomechanism of LSS, but the reason for its occurrence is not clearly elucidated. In this study, we established a novel animal model of intervertebral mechanical stress concentration and investigated the biological property of the LF. The LF with mechanical stress concentration showed degeneration with elastic fibres disruption and cartilage matrix increase, which are similar to the findings in hypertrophied LF from patients with LSS...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29020012/wearable-sensors-objectively-measure-gait-parameters-in-parkinson-s-disease
#15
Johannes C M Schlachetzki, Jens Barth, Franz Marxreiter, Julia Gossler, Zacharias Kohl, Samuel Reinfelder, Heiko Gassner, Kamiar Aminian, Bjoern M Eskofier, Jürgen Winkler, Jochen Klucken
Distinct gait characteristics like short steps and shuffling gait are prototypical signs commonly observed in Parkinson's disease. Routinely assessed by observation through clinicians, gait is rated as part of categorical clinical scores. There is an increasing need to provide quantitative measurements of gait, e.g. to provide detailed information about disease progression. Recently, we developed a wearable sensor-based gait analysis system as diagnostic tool that objectively assesses gait parameter in Parkinson's disease without the need of having a specialized gait laboratory...
2017: PloS One
https://www.readbyqxmd.com/read/29017107/vitamin-d-and-parathyroid-hormone-are-associated-with-gait-instability-and-poor-balance-performance-in-mid-age-to-older-aged-women
#16
Marie-Louise Bird, Natalie El Haber, Frances Batchelor, Keith Hill, John D Wark
CONTEXT: Vitamin D status and parathyroid hormone (PTH) levels influence the risk of accidental falls in older people, but the mechanisms underlying this effect remain unclear. OBJECTIVE: Investigate the relationship between circulating PTH and 25 hydroxyvitamin D (25-OHD) levels and clinical tests of gait stability and balance as physical fall risk factors. We hypothesized that high levels of PTH and low 25-OHD levels would be significantly associated with gait stability and decreased balance performance...
September 28, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28987772/relationship-between-margin-of-stability-and-deviations-in-spatiotemporal-gait-features-in-healthy-young-adults
#17
Shajicaa Sivakumaran, Alison Schinkel-Ivy, Kei Masani, Avril Mansfield
Increased variability of spatio-temporal features while walking is related to increased risk of falls. It is thought that variability in foot placement and timing reflects responses to mechanical instability while walking. The purpose of this study was to determine whether 'extreme' values of step length, width and time follow transient periods of low mechanical stability during the single support phase of gait in healthy young adults. We conducted secondary analysis of a portion of an existing dataset. Eleven healthy adults walked on an instrumented treadmill...
October 4, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28983222/transoral-approach-for-odontoidectomy-efficacy-and-safety
#18
Ahmed Mohamed Elbadrawi, Tameem Mohamed Elkhateeb
BACKGROUND: Odontoid process pathologies can cause upper motor neuron lesions. These pathologies can be approached through either a high retropharyngeal approach or a transoral approach. The introduction of the surgical microscope, proper instrumentations, and proper antibiotics has increased utilization of the transoral approach. QUESTIONS/PURPOSES: Our approach to anterior odontoid resection through transoral approach for different pathologies resulting in compression the cervical cord or causing craniocervical instability is described here...
October 2017: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
https://www.readbyqxmd.com/read/28960581/inhibitory-motor-dysfunction-in-parkinson-s-disease-subtypes
#19
Tao Gong, Yuanyuan Xiang, Muhammad G Saleh, Fei Gao, Weibo Chen, Richard A E Edden, Guangbin Wang
BACKGROUND: Parkinson's disease (PD) is divided into postural instability gait difficulty (PIGD) and tremor-dominant (TD) subtypes. Increasing evidence has suggested that the GABAergic neurotransmitter system is involved in the pathogenesis of PD. PURPOSE: To evaluate the differences of GABA levels between PD motor subtypes using MEscher-GArwood Point Resolved Spectroscopy (MEGA-PRESS). STUDY TYPE: COHORT.: SUBJECTS: PD patients were classified into PIGD (n = 13) and TD groups (n = 9); 16 age- and sex-matched healthy controls were also recruited...
September 27, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28960543/pedunculopontine-nucleus-deep-brain-stimulation-in-parkinson-s-disease-a-clinical-review
#20
REVIEW
Wesley Thevathasan, Bettina Debu, Tipu Aziz, Bastiaan R Bloem, Christian Blahak, Christopher Butson, Virginie Czernecki, Thomas Foltynie, Valerie Fraix, David Grabli, Carole Joint, Andres M Lozano, Michael S Okun, Jill Ostrem, Nicola Pavese, Christoph Schrader, Chun-Hwei Tai, Joachim K Krauss, Elena Moro
Pedunculopontine nucleus region deep brain stimulation (DBS) is a promising but experimental therapy for axial motor deficits in Parkinson's disease (PD), particularly gait freezing and falls. Here, we summarise the clinical application and outcomes reported during the past 10 years. The published dataset is limited, comprising fewer than 100 cases. Furthermore, there is great variability in clinical methodology between and within surgical centers. The most common indication has been severe medication refractory gait freezing (often associated with postural instability)...
September 28, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
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