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https://www.readbyqxmd.com/read/28800713/application-of-high-speed-dual-fluoroscopy-to-study-in-vivo-tibiotalar-and-subtalar-kinematics-in-patients-with-chronic-ankle-instability-and-asymptomatic-control-subjects-during-dynamic-activities
#1
Koren E Roach, K Bo Foreman, Alexej Barg, Charles L Saltzman, Andrew E Anderson
BACKGROUND: Abnormal angular and translational (ie, kinematic) motion at the tibiotalar and subtalar joints is believed to cause osteoarthritis in patients with chronic ankle instability (CAI). METHODS: In this preliminary study the investigators quantified and compared in vivo tibiotalar and subtalar kinematics in 4 patients with CAI (3 women) and 10 control subjects (5 men) using dual fluoroscopy during a balanced, single-leg heel-rise and treadmill walking at 0...
August 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28761904/iglon5-antibody-neurological-accompaniments-and-outcomes-in-20-patients
#2
Josephe A Honorat, Lars Komorowski, Keith A Josephs, Kai Fechner, Erik K St Louis, Shannon R Hinson, Sabine Lederer, Neeraj Kumar, Avi Gadoth, Vanda A Lennon, Sean J Pittock, Andrew McKeon
OBJECTIVE: To describe the phenotypes, treatment response, and outcome of IgLON5 autoimmunity. METHODS: Archived serum and CSF specimens from 367 patients known to harbor unclassified antibodies which stained neural synapses diffusely (mimicking amphiphysin-IgG) were reevaluated by indirect immunofluorescence assay (IFA) using a composite of mouse tissues and recombinant IgLON5-transfected cell-based assay (CBA, Euroimmun). RESULTS: Available specimens (serum, 25; CSF, 9) from 26/367 patients (7%) had identical IFA appearance and robust IgLON5 CBA positivity...
September 2017: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/28760559/how-to-measure-responses-of-the-knee-to-lateral-perturbations-during-gait-a-proof-of-principle-for-quantification-of-knee-instability
#3
Josien C van den Noort, Lizeth H Sloot, Sjoerd M Bruijn, Jaap Harlaar
Knee instability is a major problem in patients with anterior cruciate ligament injury or knee osteoarthritis. A valid and clinically meaningful measure for functional knee instability is lacking. The concept of the gait sensitivity norm, the normalized perturbation response of a walking system to external perturbations, could be a sensible way to quantify knee instability. The aim of this study is to explore the feasibility of this concept for measurement of knee responses, using controlled external perturbations during walking in healthy subjects...
July 18, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28754232/motor-subtype-changes-in-early-parkinson-s-disease
#4
Robert S Eisinger, Christopher W Hess, Daniel Martinez-Ramirez, Leonardo Almeida, Kelly D Foote, Michael S Okun, Aysegul Gunduz
INTRODUCTION: Distinct motor subtypes of Parkinson's disease (PD) have been described through both clinical observation and through data-driven approaches. However, the extent to which motor subtypes change during disease progression remains unknown. Our objective was to determine motor subtypes of PD using an unsupervised clustering methodology and evaluate subtype changes with disease duration. METHODS: The Parkinson's Progression Markers Initiative database of 423 newly diagnosed PD patients was utilized to retrospectively identify unique motor subtypes through a data-driven, hierarchical correlational clustering approach...
July 21, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28753030/efficacy-of-combined-treatment-with-acupuncture-and-bee-venom-acupuncture-as-an-adjunctive-treatment-for-parkinson-s-disease
#5
Seung-Yeon Cho, Young-Eun Lee, Kyeong-Hee Doo, Ji-Hyun Lee, Woo-Sang Jung, Sang-Kwan Moon, Jung-Mi Park, Chang-Nam Ko, Ho Kim, Hak Young Rhee, Hi-Joon Park, Seong-Uk Park
OBJECTIVE: The aim of this study was to evaluate the efficacy of acupuncture and bee venom acupuncture (BVA) for idiopathic Parkinson's disease (IPD) through a sham-controlled trial. We also investigated whether there is a sustained therapeutic effect by completing follow-up assessments after treatment completion. DESIGN: A single center, double-blind, three-armed randomized controlled trial. SETTINGS/LOCATION: This study was performed at a university hospital in Seoul, Republic of Korea...
July 28, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28746923/parkinsonian-patients-with-striatal-cribriform-state-present-rapidly-progressive-axial-parkinsonism
#6
Seung Ha Lee, Chul Hyoung Lyoo, Hanna Cho, Juha O Rinne, Myung Sik Lee
OBJECTIVE: To define the significance of striatal cribriform state (SCS) observed in patients with primary progressive parkinsonism. METHODS: We reviewed medical records and brain magnetic resonance imaging studies of 1,260 patients with primary progressive parkinsonism. We identified 23 patients with SCS and analyzed their clinical features. RESULTS: All 23 patients had rapidly progressive parkinsonism predominated by postural instability and gait disturbance...
July 26, 2017: European Neurology
https://www.readbyqxmd.com/read/28732483/effects-of-dual-task-and-walking-speed-on-gait-variability-in-people-with-chronic-ankle-instability-a-cross-sectional-study
#7
Shmuel Springer, Uri Gottlieb
BACKGROUND: Recent evidence suggests that impaired central sensorimotor integration may contribute to deficits in movement control experienced by people with chronic ankle instability (CAI). This study compared the effects of dual-task and walking speed on gait variability in individuals with and without CAI. METHODS: Sixteen subjects with CAI and 16 age- and gender-matched, able-bodied controls participated in this study. Stride time variability and stride length variability were measured on a treadmill under four different conditions: self-paced walking, self-paced walking with dual-task, fast walking, and fast walking with dual-task...
July 21, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28726052/transcranial-sonography-image-characteristics-in-different-parkinson-s-disease-subtypes
#8
Ai Yan Sheng, Ying Chun Zhang, Yu Jing Sheng, Cai Shan Wang, Ying Zhang, Hua Hu, Wei Feng Luo, CHun-Feng LIu
Recently, Parkinson's disease (PD) has been classified into three subtypes: postural instability gait difficulty (PIGD), tremor dominate (TD), and indeterminate PD. Transcranial sonography (TCS) is considered to be an important tool to diagnose PD. However, it is uncertain that whether there are differences in TCS image characteristics in different PD subtypes, so 373 idiopathic PD (188 PIGD, 108 TD, 77 indeterminate PD) were registered and received TCS in our investigation; also, the association between clinical characteristics and TCS results in different PD subtypes was analyzed...
July 19, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28702192/freezing-of-gait-is-an-early-clinical-feature-of-progressive-supranuclear-palsy
#9
Yasushi Osaki, Yukari Morita, Yuka Miyamoto, Kounosuke Furuta, Hirokazu Furuya
BACKGROUND AND AIM: Early clinical diagnosis of progressive supranuclear palsy (PSP) remains challenging. AIM: We attempted to identify any sign or symptom to diagnose PSP earlier. METHODS: A total of 401 patients, 40 with PSP and 361 with other neurodegenerative disorders, were included. We followed these patients for at least 1 year since 2009. We reviewed the signs and symptoms of patients with PSP in a standardized manner, and observed four manifestations: "vertical supranuclear gaze abnormality," "movement disorders," "pseudobulbar palsy" and "dementia of frontal type...
May 2017: Neurology and Clinical Neuroscience
https://www.readbyqxmd.com/read/28701941/rapid-alleviation-of-parkinson-s-disease-symptoms-via-electrostimulation-of-intrinsic-auricular-muscle-zones
#10
Yusuf O Cakmak, Hülya Apaydin, Güneş Kiziltan, Ayşegül Gündüz, Burak Ozsoy, Selim Olcer, Hakan Urey, Ozgur O Cakmak, Yasemin G Ozdemir, Sibel Ertan
Background: Deep brain stimulation of the subthalamic nucleus (STN-DBS) and the pedunculopontine nucleus (PPN) significantly improve cardinal motor symptoms and postural instability and gait difficulty, respectively, in Parkinson's disease (PD). Objective and Hypothesis: Intrinsic auricular muscle zones (IAMZs) allow the potential to simultaneously stimulate the C2 spinal nerve, the trigeminal nerve, the facial nerve, and sympathetic and parasympathetic nerves in addition to providing muscle feedback and control areas including the STN, the PPN and mesencephalic locomotor regions...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28695318/-subjective-gait-stability-in-the-elderly
#11
Theresa Hirsch, Jasmin Lampe, Katrin Michalk, Lotte Röder, Karoline Munsch, Jonas Marquardt
BACKGROUND: It can be assumed that the feeling of gait stability or gait instability in the elderly may be independent of a possible fear of falling or a history of falling when walking. Up to now, there has been a lack of spatiotemporal gait parameters for older people who subjectively feel secure when walking. OBJECTIVE: The aim of the study is to analyse the distribution of various gait parameters for older people who subjectively feel secure when walking. MATERIALS AND METHODS: In a cross-sectional study, the gait parameters stride time, step time, stride length, step length, double support, single support, and walking speed were measured using a Vicon three-dimensional motion capture system (Plug-In Gait Lower-Body Marker Set) in 31 healthy people aged 65 years and older (mean age 72 ± 3...
July 10, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28692855/recuperation-of-slow-walking-in-de-novo-parkinson-s-disease-is-more-closely-associated-with-increased-cadence-rather-than-with-expanded-stride-length
#12
Kyum-Yil Kwon, Hye Mi Lee, Sung Hoon Kang, Seon Jong Pyo, Han Jun Kim, Seong-Beom Koh
INTRODUCTION: Gait characteristics in the early stages of Parkinson's disease (PD) have been less investigated so far. Moreover, the levodopa effect on gait in early PD remains to be further elucidated. We prospectively designed the study to examine gait dynamics and effect of dopaminergic treatment in patients with de novo PD. METHODS: Spatiotemporal parameters were measured in healthy controls and drug naïve patients with PD, using computerized analysis with GAITRite system during usual gait...
July 1, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28687453/cerebellar-stroke-presenting-with-isolated-dizziness-brain-mri-in-136-patients
#13
Michael D Perloff, Nimesh S Patel, Carlos S Kase, Anuja U Oza, Barbara Voetsch, Jose R Romero
OBJECTIVE: To evaluate occurrence of cerebellar stroke in Emergency Department (ED) presentations of isolated dizziness (dizziness with a normal exam and negative neurological review of systems). METHODS: A 5-year retrospective study of ED patients presenting with a chief complaint of "dizziness or vertigo", without other symptoms or signs in narrative history or on exam to suggest a central nervous system lesion, and work-up included a brain MRI within 48h. Patients with symptoms commonly peripheral in etiology (nystagmus, tinnitus, gait instability, etc...
June 22, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28685649/misdiagnosis-cns-erdheim-chester-disease-mimicking-clippers
#14
Jillian Berkman, Caleb Ford, Emily Johnson, Beth A Malow, Joseph M Aulino
Introduction Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is an inflammatory central nervous system (CNS) disorder with particular involvement of the pons. Diagnostic criteria include a range of clinical symptoms related to the underlying brainstem pathology, visible with magnetic resonance imaging (MRI). MRI findings include the appearance of punctuate and curvilinear gadolinium enhancement 'peppering' the pons. We discuss a patient presenting with clinical and radiographic characteristics of CLIPPERS who was diagnosed with Erdheim-Chester disease (ECD)...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28677937/long-term-outcome-of-surgical-treatment-of-chiari-malformation-without-syringomyelia
#15
Lorenzo Giammattei, Mahmoud Messerer, Roy T Daniel, Nozar Aghakhani, Fabrice Parker
BACKGROUND: Surgical treatment for CM without syringomyelia is still under debate. The aim of this study was to evaluate the long term outcome of surgically treated patients for CM-I without syringomyelia. METHODS: We selected all adult patients who underwent surgery for CM-I without syringomyelia between 1993 and 2010. Only patients with long term follow-up (>5 years) were included. Clinical manifestations, radiologic features, and follow-up data were analyzed...
July 4, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28668553/the-recovery-response-to-a-novel-unannounced-laboratory-induced-slip-the-first-trial-effect-in-older-adults
#16
Xuan Liu, Sasha Reschechtko, Shuaijie Wang, Yi-Chung Clive Pai
BACKGROUND: After a single slip, older adults rapidly make adaptive changes to avoid or eliminate further backward loss of balance or a fall. This rapid adaptation has been termed the "single trial effect". The purpose of this study was to explore the relationship between the motor errors subjects experienced upon a novel slip and the selection and execution of corrective response by which they modified their ongoing gait pattern and turned it into a protective step. METHODS: A forward slip was induced in the laboratory among 145 community-living older (≥65year old) adults who were protected by an overhead full body harness system...
June 17, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28655059/association-of-autonomic-dysfunction-with-disease-progression-and-survival-in-parkinson-disease
#17
Eduardo De Pablo-Fernandez, Carmen Tur, Tamas Revesz, Andrew J Lees, Janice L Holton, Thomas T Warner
Importance: Evidence suggests that development of autonomic dysfunction (AutD) may negatively affect disease course and survival in patients with synucleinopathies. However, the few available studies on Parkinson disease (PD) have conflicting results, comprise a small number of patients, have short follow-up periods, and lack pathologic confirmation of the diagnosis. Objective: To examine the association of time of onset of AutD with disease progression and survival in PD...
August 1, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28653780/gait-training-for-chronic-ankle-instability-improves-neuromechanics-during-walking
#18
Mark A Feger, Joseph M Hart, Susan Saliba, Mark F Abel, Jay Hertel
A novel gait-training device has been shown to improve gait patterns while patients with chronic ankle instability (CAI) are using the device and our current objective was to analyze the effect of structured gait training with the device on plantar pressure and surface electromyography (sEMG) following repeated gait training sessions. Sixteen CAI patients participated. Plantar pressure and sEMG were collected simultaneously during walking pre- and post-gait training. Plantar pressure (pressure time integral, peak pressure, time to peak pressure, contact area, contact time, and center of pressure trajectory) of the entire foot and nine specific regions of the foot were recorded concurrently with sEMG root mean square amplitudes from the anterior tibialis, peroneus longus, medial gastrocnemius, and gluteus medius...
June 27, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28652971/loss-of-integrity-and-atrophy-in-cingulate-structural-covariance-networks-in-parkinson-s-disease
#19
Laura J de Schipper, Jeroen van der Grond, Johan Marinus, Johanna M L Henselmans, Jacobus J van Hilten
BACKGROUND: In Parkinson's disease (PD), the relation between cortical brain atrophy on MRI and clinical progression is not straightforward. Determination of changes in structural covariance networks - patterns of covariance in grey matter density - has shown to be a valuable technique to detect subtle grey matter variations. We evaluated how structural network integrity in PD is related to clinical data. METHODS: 3 Tesla MRI was performed in 159 PD patients. We used nine standardized structural covariance networks identified in 370 healthy subjects as a template in the analysis of the PD data...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28612427/simulation-based-investigation-of-deleterious-nssnp-s-in-atxn2-gene-and-its-structural-consequence-towards-spinocerebellar-ataxia
#20
Siddharth Sinha, Sharad Verma, Aditi Singh, Pallavi Somvanshi, Abhinav Grover
Spinocerebellar degeneration, termed as ataxia is a neurological disorder of central nervous system, characterized by limb in-coordination and a progressive gait. The patient also demonstrates specific symptoms of muscle weakness, slurring of speech, and decreased vibration senses. Expansion of polyglutamine trinucleotide (CAG) within ATXN2 gene with 35 or more repeats, results in spinocerebellar ataxia type-2. Protein ataxin-2 coded by ATXN2 gene has been reported to have a crucial role in translation of the genetic information through sequestering the histone acetyl transferases (HAT) resulting in a state of hypo-acetylation...
June 14, 2017: Journal of Cellular Biochemistry
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