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Infections head neck

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https://www.readbyqxmd.com/read/29776436/rates-and-causes-of-30-day-readmission-and-emergency-room-utilization-following-head-and-neck-surgery
#1
Vincent Wu, Stephen F Hall
BACKGROUND: Unplanned returns to hospital are common, costly, and potentially avoidable. We aimed to investigate and characterize reasons for all-cause readmissions to hospital as in-patients (IPs) and visits to the Emergency Department (ED) within 30-days following patient discharge post head and neck surgery (HNS). METHODS: Retrospective case series with chart review. All patients within the Department of Otolaryngology - Head and Neck Surgery who underwent HNS for benign and malignant disease from January 1, 2010 to May 31, 2015 were identified...
May 18, 2018: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29764025/-research-progress-in-pathogenesis-treatment-and-prognosis-of-hpv-positive-head-and-neck-squamous-cell-carcinoma
#2
C Y Shui, C Li, W Liu, Y C Cai, J Jiang, R H Sun, Y Q Zhou, G Qin
Head and neck squamous cell carcinoma (HNSCC) is the sixth common malignant tumors of whole body with a high incidence, which accounts for 90% of the head and neck malignant tumors. Previous studies have shown the risk factors, such as tobacco and alcohol, are related to the occurrence and development of HNSCC. However, recent studies have shown that the non-tobacco and non-alcohol related HNSCC increased year by year. At the same time, more and more studies have shown that HNSCC is related to the infection with human papilloma virus (HPV), and the occurrence and development of HPV-positive HNSCC has own characteristics in epidemiology, pathogenesis, treatment and prognosis...
May 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29759037/deep-head-and-neck-infections-outcome-following-empirical-therapy-with-early-generation-antibiotics
#3
Lalee Varghese, Suma Susan Mathews, John Antony Jude Prakash, V Rupa
In order to study the bacteriological profile, antibiotic sensitivity and outcome following empirical therapy with early generation antibiotics in patients with deep head and neck infection, a retrospective review of 42 patients admitted for drainage and intravenous antibiotic therapy was performed. Ludwig's angina was the commonest infection, with the most common organisms isolated being Group F ß-haemolytic (15%) and non-haemolytic (12.5%) streptococcus. All streptococci and anaerobic gram-positive cocci were susceptible to penicillin...
January 1, 2018: Tropical Doctor
https://www.readbyqxmd.com/read/29754187/nationwide-multicenter-follow-up-cohort-study-of-hip-arthroplasties-performed-for-osteonecrosis-of-the-femoral-head
#4
Seneki Kobayashi, Toshikazu Kubo, Yukihide Iwamoto, Wakaba Fukushima, Nobuhiko Sugano
PURPOSE: To identify modifiable factors related to post-operative dislocation and reoperation in patients with osteonecrosis of the femoral head (ONFH) in a large cohort. METHODS: We studied 4995 hip arthroplasties: total hip arthroplasty (THA) was performed in 79% of patients; bipolar hemiarthroplasty (BP), 17%; total resurfacing arthroplasty (tRS), 3%; and hemi-resurfacing arthroplasty (hRS), 1%. A new type of BP (accounting for 49% of BPs) comprised a femoral component with a polished or smooth, small-diameter (approximately 10 mm) neck with a round or oval axial cut surface and no sharp corners...
May 12, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29745089/hpv-infection-in-oropharyngeal-squamous-cell-carcinomas-correlation-with-tumor-size
#5
Eleftheria Gletsou, Theodoros A Papadas, Evangelia Baliou, Evangelos Tsiambas, Vasileios Ragos, Ilianna E Armata, George E Metaxas, Panagiotis P Fotiades
PURPOSE: Human papillomavirus (HPV) is implicated in carcinogenesis of a variety of epithelia, including oropharyngeal and laryngeal. High risk (HR) HPV persistent infection in head and neck squamous cell carcinomas (HNSCC) is a significant event, but its influence regarding the prognosis and survival in these patients remains under consideration. Our aim was to analyze a series of oropharyngeal (OP) SCCs at the HPV DNA level, correlating them to the survival status of the corresponding patients...
March 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29743937/epidemiologic-and-economic-burden-of-hpv-diseases-in-spain-implication-of-additional-5-types-from-the-9-valent-vaccine
#6
Noelia López, Aureli Torné, Agustín Franco, María San-Martin, Elisabet Viayna, Carmen Barrull, Nuria Perulero
Background: A new nonavalent human papillomavirus (HPV) vaccine that includes genotypes 6/11/16/18/31/33/45/52/58 has been recently approved in Spain. A previous study has shown that attributable fraction of HPV related diseases in Spain is consistent with that reported in European and global studies. The aim of the present study was to estimate the annual direct costs associated to the following HPV-related diseases: genital warts, high grade precancerous lesions and cancer of cervix, vulva, vagina, anus and penis and head and neck cancer, caused by genotypes included in the nonavalent (9vHPV) and quadrivalent vaccines (4vHPV), in Spanish men and women...
2018: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29742284/associations-among-human-papillomavirus-inflammation-and-fatigue-in-patients-with-head-and-neck-cancer
#7
Canhua Xiao, Jonathan J Beitler, Kristin A Higgins, Toby Glazer, Linh Kha Huynh, Sudeshna Paul, Jennifer C Felger, Evanthia C Wommack, Nabil F Saba, Dong M Shin, Deborah W Bruner, Andrew H Miller
BACKGROUND: Human papillomavirus (HPV) infection has contributed to an increased incidence of squamous cell carcinoma of the head and neck (SCCHN). Fatigue is a major side effect of SCCHN and its treatment. However, to the authors' knowledge, the association between HPV and fatigue has not been examined to date, nor is it known whether HPV influences biological mechanisms of fatigue, including inflammation. METHODS: Patients with SCCHN who were without distant metastasis were assessed at baseline (pre-radiotherapy) and 1 month and 3 months postradiotherapy...
May 9, 2018: Cancer
https://www.readbyqxmd.com/read/29740440/targeting-head-and-neck-cancer-by-vaccination
#8
REVIEW
Chuan Wang, James Dickie, Ruhcha V Sutavani, Catherine Pointer, Gareth J Thomas, Natalia Savelyeva
Head and neck cancer (HNC) is a heterogeneous group of squamous cell cancers that affect the oral cavity, pharynx, and larynx. Worldwide, it is the sixth most common cancer but in parts of Southern and South-East Asia, HNC is one of the most common cancers. A significant proportion of HNC is driven by human papillomavirus (HPV) infection, whereas HPV-independent HNC is associated with alcohol, smoking, and smokeless tobacco consumption. Here, we review the past and present experience of targeting HNC with vaccination focusing on HPV-derived antigens as well as non-viral antigens for HPV-negative HNC...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29727474/high-prevalence-and-correlates-of-human-herpesvirus-6a-in-nevocytic-nevus-and-seborrheic-diseases-implication-from-a-pilot-study-of-skin-patient-tissues-in-shanghai
#9
Ling Ding, Xiaohui Mo, Liming Zhang, Feng Zhou, Caixia Zhu, Yuyan Wang, Cankun Cai, Yeqiang Liu, Fang Wei, Qiliang Cai
Skin disorders vary greatly in symptoms and severity, and the causes of these disorders are largely unknown. Human herpesvirus (HHV) has been shown to cause many diseases. However, the prevalence and correlate of each HHV infection with different skin disorders remains obscure. To reveal the potential link of certain type of skin disease with herpesvirus infection, a total of 272 patient tissues with inflammatory or neoplastic skin diseases including 7 subtypes in Shanghai, China, were investigated. We found that the overall prevalence of HHV-6A in inflammatory or neoplastic skin tissues is the most common (40...
May 4, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29724775/structural-and-functional-characterization-of-the-contractile-aorta-and-associated-hemocytes-of-the-mosquito-anopheles-gambiae
#10
Leah T Sigle, Julián F Hillyer
The primary pump of the circulatory system of insects is a dorsal vessel that traverses the length of the insect. The anterior portion, located in the head, neck and thorax, is the aorta, and the posterior portion, located in the abdomen, is the heart. Here, we characterize the structure and function of the aorta and conical chamber of the mosquito, Anopheles gambiae The aorta begins in the head with an excurrent opening located above the dorsal pharyngeal plate and ends at the thoraco-abdominal junction where it joins the conical chamber of the heart...
May 3, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29723368/atypical-crusted-scabies-in-a-patient-with-chronic-liver-disease-caused-by-hepatitis-b-and-d-viruses
#11
Mônica Santos, Gustavo Ávila Maquiné, Carolina Talhari, Antonio Pedro Mendes Schettini
Crusted scabies is a less common variant of scabies that is highly contagious, difficult to treat and involves infestation by Sarcoptes scabiei var. hominis. The classical clinical presentation includes crusted, scaly and generally non-pruritic lesions usually located on the head, neck, palmar, plantar and periungual region. It was first described in Norway in 1848 in patients with leprosy who presented with crusted lesions. In this study, we report the case of a patient with crusted scabies with florid clinical manifestations and chronic liver disease due to hepatitis B and delta virus infection...
March 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29720867/synchronous-gastric-and-duodenal-metastases-from-head-and-neck-squamous-cell-carcinoma-a-unique-presentation-of-upper-gastrointestinal-bleeding
#12
Nicholas P Tarangelo, C Andrew Kistler, Zachary Daitch, Wei Jiang, Daniel M Quirk
Metastatic disease to the stomach or duodenum is an infrequent diagnosis, and head and neck squamous cell carcinoma (HNSCC) is one of the least common primary malignancies that lead to gastric or duodenal metastases. We report the case of a 65-year-old man with human immunodeficiency virus infection and previously diagnosed HNSCC who presented with melena. The patient had a percutaneous endoscopic gastrostomy tube placed 3 months prior to his presentation. Laboratory testing was significant for normocytic anemia and a digital rectal examination was positive for melena...
May 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29708483/sexual-behaviour-hpv-status-and-p16-ink4a-expression-in-oropharyngeal-and-oral-cavity-squamous-cell-carcinomas-a-case-case-comparison-study
#13
Sarah Emmett, Samuel Boros, David C Whiteman, Sandro V Porceddu, Benedict J Panizza, Annika Antonsson
A significant proportion of mucosal squamous cell carcinomas of the head and neck (HNSCC; particularly of the oropharynx) are directly attributable to the human papillomavirus (HPV). The increase in the incidence of HPV-related tumours has been postulated to be due to changing sexual practices in the community. We analysed 136 formalin-fixed paraffin-embedded squamous cell carcinomas from the oral cavity (n=40) and oropharynx (n=96) recruited from the Princess Alexandra Hospital (Brisbane, Australia). Samples were analysed for the presence of HPV DNA using a combination of mucosal HPV general primer GP+ PCR and sequencing; p16INK4a expression was assessed by immunohistochemistry...
April 30, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29708352/-anogenital-hpv-infection-as-the-potential-risk-factor-for-oropharyngeal-carcinoma
#14
Borek Sehnal, Tomáš Podlešák, Emanuela Kmoníčková, Monika Nipčová, Daniel Driák, Jiří Sláma, Michal Zikán
BACKGROUND: Human papillomavirus (HPV) can cause cervical, other genital, anal, head, and neck cancers. The incidence of oropharyngeal squamous cell carcinoma (OSCC), the head and neck cancer most commonly caused by HPV infection, is increasing. The prevalence of oral HPV infections is considerably lower than that of genital HPV infections; however, infection of both sites is strongly associated with sexual behavior. Although the natural histories of cervical and oral HPV infections do not markedly differ, the virus seems to rarely infect oral and genital sites simultaneously...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29708086/the-value-of-chest-x-ray-in-the-scottish-referral-guidelines-for-suspected-head-and-neck-cancer-in-2144-patients
#15
P Fingland, V Carswell, T Tikka, C M Douglas, J Montgomery
OBJECTIVE: In Scotland, patients with suspected head and neck cancer are referred on the basis of the Scottish Referral Guidelines for Suspected Cancer, rather than the National Institute for Health and Care Excellence guidelines. A chest X-ray should be requested by the general practitioner at the same time as referral for persistent hoarseness. The evidence for this is level 4. METHODS: This audit identified adherence to this recommendation and X-ray results. All 'urgent suspicion of cancer' referrals to the ENT department in the National Health Service Greater Glasgow and Clyde for 2015-2016 were audited...
April 30, 2018: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/29701400/endovascular-treatment-of-carotid-blowout-syndrome
#16
Roger Rodrigues, João Costa, Gabriel Anacleto, Diogo Roriz, Óscar Gonçalves
INTRODUCTION: Carotid blowout syndrome (CBS) is a life threatening complication associated with head and neck cancers (HNC) and its treatment. The mortality rate was reported to range from 3% to over 50% in the literature. Direct surgical repair of the ruptured internal carotid artery is often not technically possible due to the difficult anatomy and underlying poor co-morbid status. Endovascular techniques such as coil embolization and stent grafting offer an alternative to surgical ligation with better patient outcomes...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29698934/a-review-of-clinical-radioprotection-and-chemoprotection-for-oral-mucositis
#17
REVIEW
Bryan Oronsky, Sharad Goyal, Michelle M Kim, Pedro Cabrales, Michelle Lybeck, Scott Caroen, Neil Oronsky, Erica Burbano, Corey Carter, Arnold Oronsky
The first tenet of medicine, "primum non nocere" or "first, do no harm", is not always compatible with oncological interventions e.g., chemotherapy, targeted therapy and radiation, since they commonly result in significant toxicities. One of the more frequent and serious treatment-induced toxicities is mucositis and particularly oral mucositis (OM) described as inflammation, atrophy and breakdown of the mucosa or lining of the oral cavity. The sequelae of oral mucositis (OM), which include pain, odynodysphagia, dysgeusia, decreased oral intake and systemic infection, frequently require treatment delays, interruptions and discontinuations that not only negatively impact quality of life but also tumor control and survivorship...
April 23, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29698303/closed-reduction-osteotomy-and-fibular-graft-are-effective-in-treating-pediatric-femoral-neck-pseudarthrosis-after-infection
#18
Rajesh Kumar Kanojia, Sumit Gupta, Ajay Kumar, Bachha Kanakeya Reddy
BACKGROUND: When treatment of acute septic arthritis of the hip is delayed, severe sequelae can occur. This may take the form of coxa breva, vara, or valga. Pseudoarthrosis of the femoral neck is a rare complication with only a few studies to guide treatment. QUESTION/PURPOSES: In a small series of patients with pseudarthrosis of the femoral neck after acute septic arthritis, we wanted to determine (1) whether femoral neck union can be achieved using a variety of surgical approaches; (2) whether these patients satisfied criteria outlined by Hunka and Choi, defined as a stable hip, a flexion arc ≥ 70° and no fixed adduction or abduction contractures, fixed flexion deformity not more than 20°, pain relief, and restoration of activities of daily living after surgery; and (3) any treatment-related complications if observed...
April 23, 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29684499/evaluation-of-the-efficacy-of-the-four-tests-p16-immunochemistry-pcr-dna-and-rna-in-situ-hybridization-to-evaluate-a-human-papillomavirus-infection-in-head-and-neck-cancers-a-cohort-of-348-french-squamous-cell-carcinomas
#19
Jérémy Augustin, Sophie Outh-Gauer, Marion Mandavit, Cassandre Gasne, Ophélie Grard, Thomas Denize, Marine Nervo, Haïtham Mirghani, Ollivier Laccourreye, Pierre Bonfils, Patrick Bruneval, David Veyer, Hélène Péré, Eric Tartour, Cécile Badoual
It is now established that HPV plays a role in the development of a subset of head and neck squamous cell carcinomas (HNSCCs), notably oropharyngeal squamous cell carcinomas (SCCs). However, it is not clear which test one should use to detect HPV in oropharyngeal (OP) and non-OP SCCs. In this study, using 348 HNSCCs (126 OP SCCs and 222 non-OP SCCs), we evaluated diagnostic performances of different HPV tests in OP and non-OP SCCs: PCR, p16 immunostaining, in situ hybridization targeting DNA (DNA-CISH) and RNA (RNA-CISH), combined p16 + DNA-CISH, and combined p16 + RNA-CISH...
April 20, 2018: Human Pathology
https://www.readbyqxmd.com/read/29673737/epidemiological-features-of-cancers-of-the-oral-cavity-oropharynx-hypopharynx-and-larynx-cancer-in-r%C3%A3-union-island
#20
A Delagranda, G Leterme, E Chirpaz, C Ferdynus, C Fernandez, F Rubin
INTRODUCTION: This study had two objectives: firstly, to identify and compare characteristics of cancer of the oral cavity, oropharynx, hypopharynx and larynx in Réunion Island, a tropical French overseas territory in the southern hemisphere; and secondly, to discuss how incidence of these cancers is presented in the international literature. MATERIAL AND METHOD: A retrospective study included 599 patients diagnosed with cancer of the oral cavity, oropharynx, hypopharynx or larynx between 2009 and 2013 in Réunion Island...
April 16, 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
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