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https://www.readbyqxmd.com/read/29669884/iron-acquisition-and-siderophore-release-by-carbapenem-resistant-sequence-type-258-klebsiella-pneumoniae
#1
Victoria I Holden, Meredith S Wright, Sébastien Houle, Abigail Collingwood, Charles M Dozois, Mark D Adams, Michael A Bachman
Klebsiella pneumoniae is rapidly acquiring resistance to all known antibiotics, including carbapenems. Multilocus sequence type ST258 (sequence type 258), carrying a gene encoding the K. pneumoniae carbapenemase ( bla KPC ) on a transmissible plasmid, is the most prevalent carbapenem-resistant Enterobacteriaceae (CRE) in the United States and has disseminated worldwide. Previously, whole-genome sequencing identified core genome single nucleotide variants that divide ST258 into two distinct clades, ST258a and ST258b...
April 25, 2018: MSphere
https://www.readbyqxmd.com/read/29613971/the-impact-of-pediatric-outpatient-parenteral-antibiotic-therapy-implementation-at-a-tertiary-children-s-hospital-in-the-united-kingdom
#2
Sanjay Patel, Valentina Burzio, Helen Green, Sara Rees, Marc Tebruegge, Christine Jones, Saul N Faust
BACKGROUND: Recent advances in outpatient parenteral antibiotic therapy (OPAT) have largely focused on adult practice, and there are few published data on the safety and effectiveness of pediatric OPAT (p-OPAT). METHODS: During a 3-year-period (2012 to 2015), data were prospectively collected on patients managed within the p-OPAT service at Southampton Children's Hospital, a tertiary pediatric hospital in the South of England. RESULTS: A total of 130 p-OPAT episodes were managed during this period...
April 2, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29578687/esterase-catalyzed-siderophore-hydrolysis-activates-an-enterobactin-ciprofloxacin-conjugate-and-confers-targeted-antibacterial-activity
#3
Wilma Neumann, Martina Sassone-Corsi, Manuela Raffatellu, Elizabeth M Nolan
Enteric Gram-negative bacteria, including Escherichia coli, biosynthesize and deploy the triscatecholate siderophore enterobactin (Ent) in the vertebrate host to acquire iron, an essential nutrient. We report that Ent-Cipro, a synthetic siderophore-antibiotic conjugate based on the native Ent platform that harbors an alkyl linker at one of the catechols with a ciprofloxacin cargo attached, affords targeted antibacterial activity against E. coli strains that express the pathogen-associated iroA gene cluster...
March 26, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29545430/aripiprazole-reversed-gastroparesis-in-a-child-with-1q21-1-q21-2-microdeletion
#4
Simon S Rabinowitz, Neha Ahuja, Jennifer Gottfried
An 11-year-old Caucasian boy, with a microdeletion in the 1q21.1-q21.2 region, had multiple medical conditions including gastroparesis documented initially at the age of 5. The patient had a history of poor feeding since infancy and had been treated for gastro-oesophageal reflux disease (GERD), constipation and multiple food allergies. As a consequence of the GERD and his concurrent immunoglobulin (IgG) subclass deficiency, the patient had multiple otolaryngologic (ENT) infections and required two sinus surgeries...
March 15, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29525793/zero-surgical-site-infection-in-primary-knee-arthroplasty-with-multidisciplinary-intervention-is-it-possible
#5
Zehra Çağla Karakoç, Uğur Haklar
Surgical site infections (SSI) are among the most important complications in knee arthroplasty. In this article we aim to retrospectively evaluate effects of preoperative multidisciplinary assessment and treatment of focal infections in primary knee arthroplasty patients operated by a single surgeon in a single center. A total of 93 patients undergoing 120 primary knee arthroplasty operations were included in the study. In the preoperative assessment all patients were consulted by infectious diseases, otorhinolaryngology (ENT) and dentistry departments, and female patients additionally by gynecology departments to evaluate and treat possible focal infections...
March 1, 2018: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/29500030/respiratory-syncytial-virus-prevention-and-asthma-in-healthy-preterm-infants-a-randomised-controlled-trial
#6
Nienke M Scheltema, Elisabeth E Nibbelke, Juliëtte Pouw, Maarten O Blanken, Maroeska M Rovers, Christiana A Naaktgeboren, Natalie I Mazur, Joanne G Wildenbeest, Cornelis K van der Ent, Louis J Bont
BACKGROUND: Respiratory syncytial virus (RSV) infection is associated with subsequent wheeze and asthma. We previously reported on the causal relationship between prevention of RSV infection during infancy and reduced frequency of subsequent wheeze using a double-blind, randomised, placebo-controlled trial (MAKI). We continued follow-up and analysed the effect of RSV prevention during infancy on asthma and lung function at age 6 years. METHODS: We studied 429 infants born at 32-35 weeks of gestation between 2008-10 who had randomly received either palivizumab for RSV immunoprophylaxis or placebo during the RSV season of their first year of life...
February 27, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29490062/antibiotics-in-primary-care-in-england-which-antibiotics-are-prescribed-and-for-which-conditions
#7
F Christiaan K Dolk, Koen B Pouwels, David R M Smith, Julie V Robotham, Timo Smieszek
Objectives: To analyse antibiotic prescribing behaviour in English primary care with particular regard to which antibiotics are prescribed and for which conditions. Methods: Primary care data from 2013-15 recorded in The Health Improvement Network (THIN) database were analysed. Records with a prescription for systemic antibiotics were extracted and linked to co-occurring diagnostic codes, which were used to attribute prescriptions to clinical conditions. We further assessed which antibiotic classes were prescribed and which conditions resulted in the greatest share of prescribing...
February 1, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29488505/-the-modern-approaches-to-the-evaluation-of-the-importance-of-chronic-inflammation-in-the-mucous-membrane-of-the-middle-ear
#8
V T Pal'chun, A V Gurov, L M Mikhaleva, M V Gordienko
Despite the ever growing progress in antibiotic therapy and the advent of the new methods for this purpose, the number of patients suffering from chronic focal infection of the ENT organs has not decreased during the last decades which turns the problem of chronization of inflammation into a serious challenge for the physicians as exemplified by chronic inflammation in the mucous membrane of the middle ear. Pathological changes in the middle ear make up a large fraction of ENT diseases of importance not only for otorhinolaryngologists but also for the specialists in the related medical disciplines...
2018: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/29450387/orbital-cellulitis-and-brain-abscess-rare-complications-of-maxillo-spheno-ethmoidal-rhinosinusitis
#9
Farah Constantin, Patricia-Alexandra Niculescu, Oana Petre, Daniel Balasa, Alexandru Tunas, Ioana Rusu, Mihai Lupascu, Cristiana Orodel
Sinus infections can be complicated by ocular infections and, in late phases, by brain parenchyma infection. The article debates the case of a 12-year-old patient suffering from paucisymptomatic maxillo-spheno-ethmoidal rhinosinusitis, which was later complicated by orbital cellulitis, ending with the development of a brain abscess. The treatment is complex, initially targeting the source of the infection through draining the collection by middle maxillary antrostomy and anterior posterior ethmoidectomy, then the ablation of the brain abscess and postoperatively with prolonged massive antibiotherapy...
April 2017: Romanian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29348711/efficacy-of-empirical-therapy-with-combined-ciprofloxacin-versus-topical-drops-alone-in-patients-with-tubotympanic-chronic-suppurative-otitis-media-a-randomized-double-blind-controlled-trial
#10
Maisam Abbas Onali, Syeda Beenish Bareeqa, Sadaf Zia, Syed Ijlal Ahmed, Asneha Owais, Ahmad Nawaz Ahmad
Background: One of the prevailing otologic infections in our country is chronic suppurative otitis media, especially the tubotympanic type for which various treatment protocols are followed. Usually, oral and topical antibiotics (mainly quinolones) are given alone or in combination. There is a lack of consensus as to whether topical drops alone are effective or a combined oral and systemic therapy should be prescribed. In our study, we have attempted to observe the efficacy of empirical therapy with combined ciprofloxacin versus topical drops only in patients with tubotympanic chronic suppurative otitis media for control of infection...
2018: Clinical Medicine Insights. Ear, Nose and Throat
https://www.readbyqxmd.com/read/29335843/study-on-the-clinical-features-and-prognosis-of-penicilliosis-marneffei-without-human-immunodeficiency-virus-infection
#11
Ying-Ge Wang, Jin-Mei Cheng, Hai-Bo Ding, Xi Lin, Guo-Hao Chen, Mei Zhou, Sheng-Nan Ye
OBJECTIVE: To improve the diagnosis and treatment of Penicilliosis marneffei without human immunodeficiency virus infection. METHODS: Analyze and review the clinical features, diagnosis and treatment of six cases of P. marneffei without human immunodeficiency virus infection at The First Affiliated Hospital of Fujian Medical University. RESULTS: Two cases were diagnosed in the ENT Department, three cases in the respiratory department and one case in the dermatological department...
January 15, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29330988/microbiological-profile-from-middle-ear-and-nasopharynx-in-patients-suffering-from-chronic-active-mucosal-otitis-media
#12
Shahid Farooq Khattak, Nadeem Ahmed Sheikh, Adil Aleem, Muhammad Farooq, Kanwal Nadeem
BACKGROUND: Chronic otitis media is described as a tympanic membrane perforation and ear discharge for more than six weeks duration. Ascending infection from the nasopharynx into the middle ear cleft has been attributed to prevent resolution of chronic otitis media. This research aims to determine the association between the microbiological flora of the nasopharynx with that of the middle ear in patients suffering from chronic (active) mucosal otitis media.. METHODS: Our study is a hospital-based cross-sectional survey...
October 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29314334/wheezing-and-infantile-colic-are-associated-with-neonatal-antibiotic-treatment
#13
Berthe C Oosterloo, Ruurd M van Elburg, Nicole B Rutten, Carin M Bunkers, Clarissa E Crijns, Clemens B Meijssen, Johanna H Oudshoorn, Ger T Rijkers, Cornelis K van der Ent, Arine M Vlieger
BACKGROUND: Cohort studies have suggested that early-life antibiotic treatment is associated with increased risk of atopy. We determined whether antibiotic treatment already in the first week of life increases the risk of atopic and non-atopic disorders. METHODS: The INCA study is a prospective observational birth cohort study of 436 term infants, with follow-up of 1 year; 151 neonates received broad-spectrum antibiotics for suspected neonatal infection (AB+), vs a healthy untreated control group (N = 285; AB-)...
March 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29290238/antimicrobial-treatment-of-ent-infections
#14
R Cohen, H Haas, M Lorrot, S Biscardi, O Romain, F Vie Le Sage, V Hentgen, E Grimprel
ENT infections are the most common childhood infections and the leading causes of antibiotic prescriptions. These infections are mainly due to viruses and most of them (even if bacterial species are implicated) resolve spontaneously. Therefore, the first message is to not prescribe antibiotics in the following situations: common cold, non-streptococcal pharyngitis, laryngitis, non-purulent otitis media, etc. For sore throat/pharyngitis, the antibiotic treatment decision is based mainly on the use of group A streptococcus rapid diagnostic tests...
December 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29279722/current-diagnostic-procedures-for-diagnosing-vertigo-and-dizziness
#15
REVIEW
Leif Erik Walther
Vertigo is a multisensory syndrome that otolaryngologists are confronted with every day. With regard to the complex functions of the sense of orientation, vertigo is considered today as a disorder of the sense of direction, a disturbed spatial perception of the body. Beside the frequent classical syndromes for which vertigo is the leading symptom (e.g. positional vertigo, vestibular neuritis, Menière's disease), vertigo may occur as main or accompanying symptom of a multitude of ENT-related diseases involving the inner ear...
2017: GMS Current Topics in Otorhinolaryngology, Head and Neck Surgery
https://www.readbyqxmd.com/read/29213222/antiplasmodial-compounds-from-leaves-of-dodonaea-angustifolia
#16
Yadessa Melaku, Tefera Worku, Yemane Tadesse, Yalemtsehay Mekonnen, Juergen Schmidt, Norbert Arnold, Ermias Dagne
Background: Dodonaea angustifolia is used in Ethiopian traditional medicine to treat malaria. The objective of this work was to conduct bioassay guided fractionation of the leaves of D. angustifolia using Plasmodium berghei infected mice. Method: The antiplasmodial activity of the extracts and pure compounds was evaluated using the standard Peter's four-day suppressive method. The structures of isolated compounds were elucidated using chemi-cal and spectroscopic methods...
September 2017: Current Bioactive Compounds
https://www.readbyqxmd.com/read/29163996/lymphangiomatous-polyp-presenting-as-tonsillar-mass
#17
Ashish Dhakal, Sameer Karmacharya, Sandhya Shrestha
A 19-year-old female presented to ENT OPD of Dhulikhel Hospital, Kathmandu University Hospital, with history of foreign body sensation in throat for 2 weeks and mass in left tonsil for 1 week. There is no history of difficulty swallowing or recurrent throat infection. Physical examination revealed a pedunculated mass arising from upper pole of left tonsil. Bilateral tonsillectomy was done under general anaesthesia. Grossly, 2.5 × 1.5 × 1 cm polypoidal mass, soft in consistency, was found to be attached to left tonsil...
2017: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/29157132/in-planta-functions-of-cytochrome-p450-monooxygenase-genes-in-the-phytocassane-biosynthetic-gene-cluster-on-rice-chromosome-2
#18
Zhongfeng Ye, Kohei Yamazaki, Hiromi Minoda, Koji Miyamoto, Sho Miyazaki, Hiroshi Kawaide, Arata Yajima, Hideaki Nojiri, Hisakazu Yamane, Kazunori Okada
In response to environmental stressors such as blast fungal infections, rice produces phytoalexins, an antimicrobial diterpenoid compound. Together with momilactones, phytocassanes are among the major diterpenoid phytoalexins. The biosynthetic genes of diterpenoid phytoalexin are organized on the chromosome in functional gene clusters, comprising diterpene cyclase, dehydrogenase, and cytochrome P450 monooxygenase genes. Their functions have been studied extensively using in vitro enzyme assay systems. Specifically, P450 genes (CYP71Z6, Z7; CYP76M5, M6, M7, M8) on rice chromosome 2 have multifunctional activities associated with ent-copalyl diphosphate-related diterpene hydrocarbons, but the in planta contribution of these genes to diterpenoid phytoalexin production remains unknown...
November 20, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29149672/the-application-of-bacteriophages-as-novel-indicators-of-viral-pathogens-in-wastewater-treatment-systems
#19
Edgard Dias, James Ebdon, Huw Taylor
Many wastewater treatment technologies have been shown to remove bacterial pathogens more effectively than viral pathogens and, in aquatic environments, levels of traditional faecal indicator bacteria (FIB) do not appear to correlate consistently with levels of human viral pathogens. There is, therefore, a need for novel viral indicators of faecal pollution and surrogates of viral pathogens, especially given the increasing importance of indirect and direct wastewater reuse. Potential candidates include bacteriophages (phages) and the study described here sought to elucidate the relationship between three groups of phages (somatic coliphages (SOMPH), F-RNA coliphages (F-RNAPH) and human-specific phages infecting B...
February 1, 2018: Water Research
https://www.readbyqxmd.com/read/29131135/interhemispheric-and-infratentorial-subdural-empyema-with-preseptal-cellulitis-as-complications-of-sinusitis-a-case-report
#20
Muhammad Reza Arifianto, Achmad Zuhro Ma'ruf, Arie Ibrahim, Abdul Hafid Bajamal
Intracranial complications of paranasal sinusitis have become rare due to the use of antibiotics nowadays. However, several cases have been reported due the ability of paranasal sinusitis to cause serious complications. Once the infection spreads over the cranial structure, it could infect the orbits, underlying bones, meninges, adjacent veins, and brain. Subdural empyema is a rare but potentially life-threatening complication following paranasal sinusitis and should be considered as a neurological emergency...
November 11, 2017: Pediatric Neurosurgery
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