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Infections ENT

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https://www.readbyqxmd.com/read/28096867/nasal-nosocomial-myiasis-infection-caused-by-chrysomya-bezziana-diptera-calliphoridae-following-the-septicemia-a-case-report
#1
Seyed Farzin Mircheraghi, Seyed Farzam Mircheraghi, Hamed Ramezani Awal Riabi, Arezoo Parsapour
A 74 yr old woman from Gonabad, southern part of Khorasan Razavi Province of Iran was admitted to a Hospital of Gonabad, because of respiratory distress, exertional dyspnea and fever. Close contact with domestic animals, history of chronic obstructive pulmonary disease (COPD), and completely resolved pulmonary tuberculosis (TB) in remote past, were notable parts of her past medical history. Due to clinical, paraclinical and radiographic findings and because of recent hospitalization, she was admitted to internal medicine ward with the diagnosis of health care associated pneumonia (HCAP)...
April 2016: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28061917/upper-respiratory-infections-and-barotrauma-among-commercial-pilots
#2
Nina Monrad Boel, Mads Klokker
BACKGROUND: Health incapacitation is a serious threat to flight safety. Therefore, a study conducted 10 yr ago examined the incidents of ear-nose-throat (ENT) barotrauma and upper respiratory infection (URI) among commercial pilots and found that a large number continued to carry out their duties despite the risk of incapacitation. Now, 10 yr later, this new study examines if the attention to URIs has improved. METHOD: This study was conducted at the Danish Aeromedical Centre over the course of 1 yr with 463 valid respondents to a questionnaire on URIs and ENT barotrauma...
January 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28009937/needle-aspiration-versus-incision-and-drainage-for-the-treatment-of-peritonsillar-abscess
#3
REVIEW
Brent A Chang, Andrew Thamboo, Martin J Burton, Chris Diamond, Desmond A Nunez
BACKGROUND: Peritonsillar abscess is a common infection presenting as a collection of pus in the peritonsillar area. The condition is characterised by a severe sore throat, difficulty in swallowing and pain on swallowing, fever and malaise, and trismus. Needle aspiration and incision and drainage are the two main treatment modalities currently used in the treatment of this condition. The effectiveness of one versus the other has not been clearly demonstrated and remains an area of debate...
December 23, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28008326/localization-and-transcriptional-responses-of-chrysoporthe-austroafricana-in-eucalyptus-grandis-identify-putative-pathogenicity-factors
#4
Ronishree Mangwanda, Lizahn Zwart, Nicolaas A van der Merwe, Lucy Novungayo Moleleki, Dave Kenneth Berger, Alexander A Myburg, Sanushka Naidoo
Chrysoporthe austroafricana is a fungal pathogen that causes the development of stem cankers on susceptible Eucalyptus grandis trees. Clones of E. grandis that are partially resistant and highly susceptible have been identified based on the extent of lesion formation on the stem upon inoculation with C. austroafricana. These interactions have been used as a model pathosystem to enhance our understanding of interactions between pathogenic fungi and woody hosts, which may be different to herbaceous hosts. In previous research, transcriptomics of host responses in these two clones to C...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27995448/functional-characterization-of-human-equilibrative-nucleoside-transporter-1
#5
Weiyun Huang, Xin Zeng, Yigong Shi, Minhao Liu
Equilibrative nucleoside transporters (ENTs), which facilitate cross-membrane transport of nucleosides and nucleoside-derived drugs, play an important role in the salvage pathways of nucleotide synthesis, cancer chemotherapy, and treatment for virus infections. Functional characterization of ENTs at the molecular level remains technically challenging and hence scant. In this study, we report successful purification and biochemical characterization of human equilibrative nucleoside transporter 1 (hENT1) in vitro...
December 19, 2016: Protein & Cell
https://www.readbyqxmd.com/read/27888123/acute-rhinosinusitis-during-hajj-season-2014-prevalence-of-bacterial-infection-and-patterns-of-antimicrobial-susceptibility
#6
Osama A Marglani, Ameen Z Alherabi, Islam R Herzallah, Faisal A Saati, Enas A Tantawy, Talal A Alandejani, Hani S Faidah, Naif A Bawazeer, Abdullah A Marghalani, Tariq A Madani
BACKGROUND: The presence of large number of pilgrims during Hajj in Makkah region increases the risk of respiratory diseases. In this study, we aimed to assess the bacteriology of acute rhinosinusitis (ARS) during Hajj season and to demonstrate the antimicrobial susceptibility patterns that should guide the clinicians towards more appropriate antibiotic use. METHODS: Patients with ARS presenting during Hajj season of 2014 were prospectively enrolled. According to EPOS2012 criteria...
November 2016: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/27885599/characterization-of-high-affinity-iron-acquisition-systems-in-campylobacter-jejuni
#7
Ximin Zeng, Jun Lin
Iron acquisition systems are critical for bacterial pathogenesis and thus have been proposed as attractive targets for iron-dependent pathogen control. Of these systems, high-affinity iron acquisition mediated by siderophore, a small iron chelator, is the most efficient iron-scavenging mechanism in gram-negative bacteria. Campylobacter does not produce any siderophores but has the ability to utilize exogenous siderophores. In particular, the enterobactin (Ent)-mediated iron scavenging is tightly linked to Campylobacter pathogenesis...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27855217/screening-of-fungi-for-biological-control-of-a-triatomine-vector-of-chagas-disease-temperature-and-trypanosome-infection-as-factors
#8
Aline R M Garcia, Adriana de Paula Rocha, Camila C Moreira, Silma L Rocha, Alessandra A Guarneri, Simon L Elliot
Entomopathogenic fungi have been investigated as an alternative tool for controlling various insects, including triatomine vectors of the protozoan Trypanosoma cruzi, the etiological agent of Chagas disease. Here we tested the pathogenicity and virulence of ten isolates of the fungi Metarhizium spp. and Beauveria bassiana against Rhodnius prolixus and found all of the isolates to be virulent. We used two isolates (URPE-11 Metarhizium anisopliae and ENT-1 Beauveria bassiana) for further screening based on their prolific sporulation in vitro (an important property of fungal biopesticides)...
November 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27833652/molecular-detection-of-epstein-barr-virus-in-nasopharyngeal-carcinoma-among-sudanese-population
#9
Ali Edreis, Mona Ali Mohamed, Nouh S Mohamed, Emmanuel E Siddig
BACKGROUND: Nasopharyngeal carcinoma (NPC) is the most common cancer arising from the nasopharynx that varies significantly from other cancers of the head and neck in its occurrence, causes, clinical behavior, and treatment. NPC caused by an interaction between infection with EBV and environmental and genetic factors, encompasses a multistep oncogenic process. The frequency of Epstein-Barr virus EBV among nasopharyngeal carcinoma is well known worldwide, however, in the Sudan there is barely a published data...
2016: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/27828650/leg-ulcer-in-lepromatous-leprosy-case-report
#10
Tania Rita Moreno de Oliveira Fernandes, Talita Suzany Siqueira Dos Santos, Ramon Rodrigues de Macedo Lopes
In Brazil, leprosy is a widespread infectious and contagious disease. Clinicians and specialists view leprosy broadly as a systemic infection, since, in its manifestations, it mimics many conditions, such as rheumatic, vascular, ENT, neurological and dermatological diseases. There are few studies that characterize the factors associated with ulcers in leprosy. These injuries should be prevented and treated promptly to avoid serious problems like secondary infections, sepsis, carcinomatous degeneration and amputations...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/27781965/-a-patient-with-melkersson-rosenthal-syndrome
#11
W P J van Oosterhout, J Haan, N D Kruyt
BACKGROUND: Melkersson-Rosenthal syndrome (MRS) is a relatively rare syndrome characterised by the clinical triad of persisting or recurrent facial oedema, recurrent peripheral facial palsy, and a fissured tongue. CASE DESCRIPTION: A 30-year-old male patient presented with a left peripheral facial palsy spreading to the right side of the face. The left-sided facial paralysis recurred twice after initial recovery. The patient had also suffered from oedema of the lip and face, which sometimes occurred simultaneously with the paralysis, and he had always had a fissured tongue...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27770813/childhood-onset-granulomatosis-with-polyangiitis-and-microscopic-polyangiitis-systematic-review-and-meta-analysis
#12
Michele Iudici, Pierre Quartier, Benjamin Terrier, Luc Mouthon, Loïc Guillevin, Xavier Puéchal
BACKGROUND: The data from cohorts of childhood-onset granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) remain scarce and heterogeneous. We aimed to analyse the features at presentation, therapeutic approaches and the disease course of these rare diseases. METHODS: Electronic searches of Medline and the Cochrane Central Register of Controlled trials database were conducted. We also checked the reference lists of the studies included and other systematic reviews, to identify additional reports...
October 22, 2016: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/27707990/efficacy-of-ceftolozane-tazobactam-against-urinary-tract-and-intra-abdominal-infections-caused-by-esbl-producing-escherichia-coli-and-klebsiella-pneumoniae-a-pooled-analysis-of-phase-3-clinical-trials
#13
Myra W Popejoy, David L Paterson, Daniel Cloutier, Jennifer A Huntington, Benjamin Miller, Caleb A Bliss, Judith N Steenbergen, Ellie Hershberger, Obiamiwe Umeh, Keith S Kaye
OBJECTIVES: The increase in infections caused by drug-resistant ESBL-producing Enterobacteriaceae (ESBL-ENT) is a global concern. The characteristics and outcomes of patients infected with ESBL-ENT were examined in a pooled analysis of Phase 3 clinical trials of ceftolozane/tazobactam in patients with complicated urinary tract infections (ASPECT-cUTI) and complicated intra-abdominal infections (ASPECT-cIAI). METHODS: Trials were randomized and double blind. The ASPECT-cUTI regimen was 7 days of either intravenous ceftolozane/tazobactam (1...
January 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27707916/antibiotic-prescribing-by-physicians-versus-nurse-practitioners-for-pediatric-upper-respiratory-infections
#14
Elisabeth H Ference, Jin-Young Min, Rakesh K Chandra, James W Schroeder, Jody D Ciolino, Amy Yang, Jane Holl, Stephanie Shintani Smith
BACKGROUND: This study investigates differences in antibiotic prescribing rates for pediatric upper respiratory infections (URIs) between physicians and nurse practitioners (NPs). METHODS: Visits by children <18 years old diagnosed with URI to physicians or NPs between 2001 and 2010 were abstracted from the National Ambulatory Medical Care Survey and National Hospital Ambulatory Care Survey. Logistic regression analyses examined variations in antibiotic prescribing rates...
December 2016: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/27686946/temozolomide-chemotherapy-versus-radiotherapy-in-high-risk-low-grade-glioma-eortc-22033-26033-a-randomised-open-label-phase-3-intergroup-study
#15
Brigitta G Baumert, Monika E Hegi, Martin J van den Bent, Andreas von Deimling, Thierry Gorlia, Khê Hoang-Xuan, Alba A Brandes, Guy Kantor, Martin J B Taphoorn, Mohamed Ben Hassel, Christian Hartmann, Gail Ryan, David Capper, Johan M Kros, Sebastian Kurscheid, Wolfgang Wick, Roelien Enting, Michele Reni, Brian Thiessen, Frederic Dhermain, Jacoline E Bromberg, Loic Feuvret, Jaap C Reijneveld, Olivier Chinot, Johanna M M Gijtenbeek, John P Rossiter, Nicolas Dif, Carmen Balana, Jose Bravo-Marques, Paul M Clement, Christine Marosi, Tzahala Tzuk-Shina, Robert A Nordal, Jeremy Rees, Denis Lacombe, Warren P Mason, Roger Stupp
BACKGROUND: Outcome of low-grade glioma (WHO grade II) is highly variable, reflecting molecular heterogeneity of the disease. We compared two different, single-modality treatment strategies of standard radiotherapy versus primary temozolomide chemotherapy in patients with low-grade glioma, and assessed progression-free survival outcomes and identified predictive molecular factors. METHODS: For this randomised, open-label, phase 3 intergroup study (EORTC 22033-26033), undertaken in 78 clinical centres in 19 countries, we included patients aged 18 years or older who had a low-grade (WHO grade II) glioma (astrocytoma, oligoastrocytoma, or oligodendroglioma) with at least one high-risk feature (aged >40 years, progressive disease, tumour size >5 cm, tumour crossing the midline, or neurological symptoms), and without known HIV infection, chronic hepatitis B or C virus infection, or any condition that could interfere with oral drug administration...
November 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27677236/-amoxicillin-and-paracetamol-dosing-in-children-playing-safe
#16
B Peters, E G P M de Bont, J W L Cals
Amoxicillin and paracetamol are the two most widely prescribed and recommended medicines in children. Due to lack of scientific evidence of the most effective dosage, dosing instructions of both medicines are often unclear. In this article we challenge general practitioners, paediatricians, child-health clinic physicians, ENT specialists, pharmacists and guideline committees to critically evaluate the current dosing instructions of these two medicines. The Netherlands paediatric formulary, the Kinderformularium, should become the primary formulary for children in the Netherlands, but it has to be more in line with daily practice, and basic dosing instructions should be less ambiguous: (a) dosing instructions based on body weight instead of age; b) in case of pain, paracetamol should be given 60 mg/kg/day in four divided doses; (c) in case of common uncomplicated infections, amoxicillin should be given orally 60 mg/kg/day in two divided doses; (d) the following should be mentioned on the antibiotic prescription: the daily dose, the number of divided doses, the duration of therapy, the indication for the prescription, and the child's weight...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27591064/surgical-treatment-of-spondylitis-and-diaphragm-relaxation-in-patient-less-than-1-year-old
#17
A Y Mushkin, E Y Malyarova, V A Evseev, P K Yablonskii
DESIGN: Case report. INTRODUCTION: The combination of severe post-infectious kyphosis and diaphragm relaxation is extremely rare in patient early than 1 year old. Its no publications concerning their simultaneous surgical treatment. CASE DESCRIPTION: 7-Month-old girl had simultaneous spinal reconstruction with anterior and posterior instrumentation and plastic of diaphragm because of sequelae of non-granulenatous spondylitis complicated by severe kyphosis (54°) and diaphragm relaxation...
2016: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/27562477/therapeutic-exercises-for-affecting-post-treatment-swallowing-in-people-treated-for-advanced-stage-head-and-neck-cancers
#18
REVIEW
Alison Perry, Siew Hwa Lee, Susan Cotton, Catriona Kennedy
BACKGROUND: Head and neck cancer treatment has developed over the last decade, with improved mortality and survival rates, but the treatments often result in dysphagia (a difficulty in swallowing) as a side effect. This may be acute, resolving after treatment, or remain as a long-term negative sequela of head and neck cancer (HNC) treatment. Interventions to counteract the problems associated with dysphagia include swallowing exercises or modification of diet (bolus texture, size), or both...
August 26, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27559009/genetics-and-pathophysiology-of-granulomatosis-with-polyangiitis-gpa-and-its-main-autoantigen-proteinase-3
#19
REVIEW
Manfred Relle, Bernd Föhr, Federica Fasola, Andreas Schwarting
Granulomatosis with polyangiitis (GPA) is a severe autoimmune disease and one of the small vessel anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides. Although its etiology and pathophysiology are still widely unknown, it is accepted that infections, environmental factors, epigenetic modifications, and a genetic predisposition provide the basis for this systemic disorder. GPA typically evolves into two phases: an initial phase characterized by ear, nose and throat (ENT) manifestations, such as chronic sinusitis and otitis, ulceration of the oral cavity and pharynx, as well as pulmonary nodules and a severe generalized phase, defined by the occurrence of rapidly progressive glomerulonephritis, pulmonary hemorrhage, and arthritis...
December 2016: Molecular and Cellular Probes
https://www.readbyqxmd.com/read/27521624/botrytis-cinerea-can-import-and-utilize-nucleosides-in-salvage-and-catabolism-and-bcent-functions-as-high-affinity-nucleoside-transporter
#20
Manuel Daumann, Philippe Golfier, Nathalie Knüppel, Matthias Hahn, Torsten Möhlmann
Nucleotide de novo synthesis is an essential pathway in nearly all organisms. Transport processes as well as salvage and catabolism of nucleotides and pathway intermediates are required to balance nucleotide pools. We have analysed the genome of the fungal plant pathogen Botrytis cinerea for genes involved in nucleotide metabolism and found a complete set of genes necessary for purine and pyrimidine uptake and salvage based on homology of the gene products to corresponding proteins from Aspergillus nidulans...
August 2016: Fungal Biology
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