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https://www.readbyqxmd.com/read/27807161/bottom-up-versus-top-down-induction-of-sleep-by-zolpidem-acting-on-histaminergic-and-neocortex-neurons
#1
David S Uygun, Zhiwen Ye, Anna Y Zecharia, Edward C Harding, Xiao Yu, Raquel Yustos, Alexei L Vyssotski, Stephen G Brickley, Nicholas P Franks, William Wisden
: Zolpidem, a GABAA receptor-positive modulator, is the gold-standard drug for treating insomnia. Zolpidem prolongs IPSCs to decrease sleep latency and increase sleep time, effects that depend on α2 and/or α3 subunit-containing receptors. Compared with natural NREM sleep, zolpidem also decreases the EEG power, an effect that depends on α1 subunit-containing receptors, and which may make zolpidem-induced sleep less optimal. In this paper, we investigate whether zolpidem needs to potentiate only particular GABAergic pathways to induce sleep without reducing EEG power...
November 2, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27673090/poster-336-the-paradoxical-improvement-of-motor-and-speech-function-with-the-use-of-zolpidem-ambien-in-patients-with-anoxic-encephalopathy-and-tbi
#2
Jeffrey M Derbas, Anjum Sayyad
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/26887671/the-hindlimb-myology-of-tyto-alba-tytonidae-strigiformes-aves
#3
M C Mosto
This work is the first myological dissection performed in detail on the hindlimb of Tyto alba. Six specimens were dissected and their muscle masses were obtained. T. alba has the classical myological pattern present in other species of Strigiformes, such as a well-developed m. flexor digitorum longus and the absence of the m. plantaris, flexor cruris lateralis and ambiens. Also, T. alba lacks the m. extensor propius digiti III, m. extensor propius digiti IV and m. lumbricalis, present in the Strigidae...
February 17, 2016: Anatomia, Histologia, Embryologia
https://www.readbyqxmd.com/read/26644946/impact-of-a-us-food-and-drug-administration-drug-safety-communication-on-zolpidem-dosing-an-observational-retrospective-cohort
#4
Jonathan L Harward, Valerie B Clinard, Michael R Jiroutek, Beverly H Lingerfeldt, Andrew J Muzyk
INTRODUCTION/BACKGROUND: Zolpidem is a sedative-hypnotic widely prescribed in the United States. Recently, the US Food and Drug Administration (FDA) issued a drug safety communication regarding its dosing in women. OBJECTIVE: To compare compliance with FDA-approved dosing for zolpidem in women before and after a drug safety communication, and to evaluate compliance based on pharmacy location and prescriber type. METHOD: This was a retrospective, observational cohort study...
2015: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/26529448/check-that-ambien-dose
#5
Ann Shastay
No abstract text is available yet for this article.
November 2015: Home Healthcare Now
https://www.readbyqxmd.com/read/26054530/characterizing-sleep-issues-using-twitter
#6
David J McIver, Jared B Hawkins, Rumi Chunara, Arnaub K Chatterjee, Aman Bhandari, Timothy P Fitzgerald, Sachin H Jain, John S Brownstein
BACKGROUND: Sleep issues such as insomnia affect over 50 million Americans and can lead to serious health problems, including depression and obesity, and can increase risk of injury. Social media platforms such as Twitter offer exciting potential for their use in studying and identifying both diseases and social phenomenon. OBJECTIVE: Our aim was to determine whether social media can be used as a method to conduct research focusing on sleep issues. METHODS: Twitter posts were collected and curated to determine whether a user exhibited signs of sleep issues based on the presence of several keywords in tweets such as insomnia, "can't sleep", Ambien, and others...
2015: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/25984566/putting-tuberculosis-tb-to-rest-transformation-of-the-sleep-aid-ambien-and-anagrams-generated-potent-antituberculosis-agents
#7
Garrett C Moraski, Patricia A Miller, Mai Ann Bailey, Juliane Ollinger, Tanya Parish, Helena I Boshoff, Sanghyun Cho, Jeffery R Anderson, Surafel Mulugeta, Scott G Franzblau, Marvin J Miller
Zolpidem (Ambien, 1) is an imidazo[1,2-a]pyridine-3-acetamide and an approved drug for the treatment of insomnia. As medicinal chemists enamored by how structure imparts biological function, we found it to have strikingly similar structure to the antitubercular imidazo[1,2-a]pyridine-3-carboxyamides. Zolpidem was found to have antituberculosis activity (MIC of 10-50 μM) when screened against replicating Mycobacterium tuberculosis (Mtb) H37Rv. Manipulation of the Zolpidem structure, notably, to structural isomers ("anagrams"), attains remarkably improved potency (5, MIC of 0...
February 13, 2015: ACS Infectious Diseases
https://www.readbyqxmd.com/read/25217539/determining-zolpidem-compliance-urinary-metabolite-detection-and-prevalence-in-chronic-pain-patients
#8
David M Schwope, Anne DePriest, David L Black, Yale H Caplan, Edward J Cone, Rebecca Heltsley
Zolpidem (Ambien(®)) is the most prescribed insomnia treatment in the USA; however, little is known about zolpidem metabolite excretion in chronic pain patients. As zolpidem is extensively metabolized in vivo to zolpidem 4-phenyl carboxylic acid (ZCA), metabolite detection may provide improved accuracy for compliance determinations, thereby improving clinical decisions. Zolpidem and ZCA were extracted from 1 mL human urine by mixed-mode solid-phase extraction. Samples were analyzed by LC-MS-MS using positive electrospray ionization with multiple reaction monitoring mode employed for detection and quantification...
October 2014: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/25082715/zolpidem-increases-gaba-in-depressed-volunteers-maintained-on-ssris
#9
Stephanie C Licata, J Eric Jensen, Nina A Conn, Jeffrey P Winer, Scott E Lukas
Individuals with major depressive disorder (MDD) often use hypnotics like zolpidem (Ambien(®)) to improve sleep in addition to their selective serotonin reuptake inhibitor (SSRI) regimen. SSRIs act in part to restore disrupted GABAergic activity, but benzodiazepines and related drugs have been shown to lower GABA in a way that may be counter to these therapeutic effects. The present within-subject, single-blind, placebo-controlled study measured changes in GABA in the anterior cingulate (ACC) and thalamus of volunteers maintained on SSRIs for the treatment of MDD (n=14) following zolpidem (10mg) administration...
October 30, 2014: Psychiatry Research
https://www.readbyqxmd.com/read/24500894/hindlimb-myology-of-the-monk-parakeet-aves-psittaciformes
#10
Julieta Carril, María C Mosto, Mariana B J Picasso, Claudia P Tambussi
We studied the hindlimb myology of the monk parakeet (Myiopsitta monachus). Like all parrots, it has zygodactyl feet enabling perching, climbing, hanging, moving easily among trees, and handling food. Muscles were described and weighed, and physiological cross-sectional area (PCSA) of four flexors and one extensor was calculated. In comparison to other muscles, the M. tibialis cranialis and the M. fibularis brevis show increased development and high PCSA values, and therefore, large potential force production...
July 2014: Journal of Morphology
https://www.readbyqxmd.com/read/24420426/insect-feeding-and-oviposition-deterrents-from-western-red-cedar-foliage
#11
R I Alfaro, H D Pierce, J H Borden, A C Oehlschlager
The feeding deterrent activity of fractions from the foliage of western red cedar,Thujaplicata Donn, was studied in laboratory bioassays using the white pine weevil,Pissodes strobi Peck, as a test insect. The most active fraction was the volatile mixture that comprises the leaf oil of this tree species. Further fractionation of the leaf oil indicated feeding deterrent activity in the monoterpene hydrocarbon, thujone, and terpene alcohol fractions. When tested alone, both (-)-3-isothujone and (+)-3-thujone, which made up 75-88% and 5-10% of the leaf oil, respectively, deterred feeding by the weevils...
January 1981: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/23923991/zolpidem-and-driving-impairment-identifying-persons-at-risk
#12
Ronald H Farkas, Ellis F Unger, Robert Temple
Zolpidem (Ambien, Sanofi) is the most widely used prescription drug for insomnia and one of the most commonly used drugs in the United States. Treatment of insomnia, which has important effects on patients' quality of life, may also have larger public health benefits. In its 2006 report, the..
August 22, 2013: New England Journal of Medicine
https://www.readbyqxmd.com/read/23767926/pharmacologically-increasing-sleep-spindles-enhances-recognition-for-negative-and-high-arousal-memories
#13
Erik J Kaestner, John T Wixted, Sara C Mednick
Sleep affects declarative memory for emotional stimuli differently than it affects declarative memory for nonemotional stimuli. However, the interaction between specific sleep characteristics and emotional memory is not well understood. Recent studies on how sleep affects emotional memory have focused on rapid eye movement sleep (REM) but have not addressed non-REM sleep, particularly sleep spindles. This is despite the fact that sleep spindles are implicated in declarative memory as well as neural models of memory consolidation (e...
October 2013: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/23767248/addicted-to-sleep-a-case-of-ambien-abuse
#14
Niraj Chapla, Gerard Gallucci, Imran Trimzi, Bradley R Meier
No abstract text is available yet for this article.
April 2013: Delaware Medical Journal
https://www.readbyqxmd.com/read/23552372/orexin-receptor-antagonists-differ-from-standard-sleep-drugs-by-promoting-sleep-at-doses-that-do-not-disrupt-cognition
#15
Jason M Uslaner, Spencer J Tye, Donnie M Eddins, Xiaohai Wang, Steven V Fox, Alan T Savitz, Jacquelyn Binns, Christopher E Cannon, Susan L Garson, Lihang Yao, Robert Hodgson, Joanne Stevens, Mark R Bowlby, Pamela L Tannenbaum, Joseph Brunner, Terrence P Mcdonald, Anthony L Gotter, Scott D Kuduk, Paul J Coleman, Christopher J Winrow, John J Renger
Current treatments for insomnia, such as zolpidem (Ambien) and eszopiclone (Lunesta), are γ-aminobutyric acid type A (GABAA)-positive allosteric modulators that carry a number of side effects including the potential to disrupt cognition. In an effort to develop better tolerated medicines, we have identified dual orexin 1 and 2 receptor antagonists (DORAs), which promote sleep in preclinical animal models and humans. We compare the effects of orally administered eszopiclone, zolpidem, and diazepam to the dual orexin receptor antagonist DORA-22 on sleep and the novel object recognition test in rat, and on sleep and two cognition tests (delayed match to sample and serial choice reaction time) in the rhesus monkey...
April 3, 2013: Science Translational Medicine
https://www.readbyqxmd.com/read/23467365/the-critical-role-of-sleep-spindles-in-hippocampal-dependent-memory-a-pharmacology-study
#16
RANDOMIZED CONTROLLED TRIAL
Sara C Mednick, Elizabeth A McDevitt, James K Walsh, Erin Wamsley, Martin Paulus, Jennifer C Kanady, Sean P A Drummond
An important function of sleep is the consolidation of memories, and features of sleep, such as rapid eye movement (REM) or sleep spindles, have been shown to correlate with improvements in discrete memory domains. Because of the methodological difficulties in modulating sleep, however, a causal link between specific sleep features and human memory consolidation is lacking. Here, we experimentally manipulated specific sleep features during a daytime nap via direct pharmacological intervention. Using zolpidem (Ambien), a short-acting GABAA agonist hypnotic, we show increased sleep spindle density and decreased REM sleep compared with placebo and sodium oxybate (Xyrem)...
March 6, 2013: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/23445185/treatment-of-insomnia-in-older-adults-re-evaluating-the-benefits-and-risks-of-sedative-hypnotic-agents
#17
Nicole J Brandt, Jennifer M Piechocki
Insomnia and sleep complaints are common among older adults. Although once considered safer than benzodiazepine drugs, recent data on non-benzodiazepine drugs, such as zolpidem (Ambien(®)), have revealed similar negative effects. This issue, as well as others, has been included in the recent updated 2012 American Geriatrics Society Beers Criteria. This article describes the risks and benefits associated with sedative hypnotic agents in older adults and discusses the conundrum facing practitioners as well as patients...
April 2013: Journal of Gerontological Nursing
https://www.readbyqxmd.com/read/23296183/the-hypnotic-zolpidem-increases-the-synchrony-of-bold-signal-fluctuations-in-widespread-brain-networks-during-a-resting-paradigm
#18
Stephanie C Licata, Lisa D Nickerson, Steven B Lowen, George H Trksak, Robert R Maclean, Scott E Lukas
Networks of brain regions having synchronized fluctuations of the blood oxygen level-dependent functional magnetic resonance imaging (BOLD fMRI) time-series at rest, or "resting state networks" (RSNs), are emerging as a basis for understanding intrinsic brain activity. RSNs are topographically consistent with activity-related networks subserving sensory, motor, and cognitive processes, and studying their spontaneous fluctuations following acute drug challenge may provide a way to understand better the neuroanatomical substrates of drug action...
April 15, 2013: NeuroImage
https://www.readbyqxmd.com/read/22795592/the-misuse-of-ambien-among-adolescents-prevalence-and-correlates-in-a-national-sample
#19
Jason A Ford, James McCutcheon
The current research examines correlates of Ambien misuse among adolescents. Given the recent popularity of prescription drug misuse, the known risks associated with prescription drugs, the fact that Ambien is widely prescribed, and the relative lack of research on prescription sedative misuse, we believe this research is important. The current study fills this important gap in the literature by examining data from the 2009 National Survey on Drug Use and Health, which includes a sample of more than 17,000 adolescents ages 12 to 17 that is generalizable to the non-institutionalized population of the United States...
December 2012: Addictive Behaviors
https://www.readbyqxmd.com/read/22278753/use-of-partial-auc-to-demonstrate-bioequivalence-of-zolpidem-tartrate-extended-release-formulations
#20
Robert A Lionberger, Andre S Raw, Stephanie H Kim, Xinyuan Zhang, Lawrence X Yu
PURPOSE: FDA's bioequivalence recommendation for Zolpidem Tartrate Extended Release Tablets is the first to use partial AUC (pAUC) metrics for determining bioequivalence of modified-release dosage forms. Modeling and simulation studies were performed to aid in understanding the need for pAUC measures and also the proper pAUC truncation times. METHODS: Deconvolution techniques, In Vitro/In Vivo Correlations, and the CAT (Compartmental Absorption and Transit) model were used to predict the PK profiles for zolpidem...
April 2012: Pharmaceutical Research
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