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JOURNAL ARTICLE
Marie Jakobs, Tina Hörbelt-Grünheidt, Martin Hadamitzky, Julia Bihorac, Yasmin Salem, Stephan Leisengang, Uwe Christians, Björn Schniedewind, Manfred Schedlowski, Laura Lückemann
Suppression of immune functions can be elicited by behavioural conditioning using drugs such as cyclosporin A or rapamycin. Nevertheless, little is known about the underlying mechanisms and generalisability of this phenomenon. Against this background, the present study investigated whether the pharmacological properties of fingolimod (FTY720), an immunosuppressive drug widely applied to treat multiple sclerosis, can be conditioned in rats by means of taste-immune associative learning. For this purpose, a conditioned taste avoidance paradigm was used, pairing the presentation of a novel sweet drinking solution (saccharin or sucrose) as conditioned stimulus (CS) with therapeutically effective doses of FTY720 as unconditioned stimulus (US)...
May 11, 2024: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
#2
REVIEW
Rishika Dhapola, Bikash Medhi, Dibbanti HariKrishnaReddy
Molecular pathways involved in cerebral stroke are diverse. The major pathophysiological events that are observed in stroke comprises of excitotoxicity, oxidative stress, mitochondrial damage, endoplasmic reticulum stress, cellular acidosis, blood-brain barrier disruption, neuronal swelling and neuronal network mutilation. Various biomolecules are involved in these pathways and several major proteins are upregulated and/or suppressed following stroke. Different types of receptors, ion channels and transporters are activated...
May 11, 2024: Molecular Biology Reports
#3
JOURNAL ARTICLE
Stefan J Blaschke, Nora Rautenberg, Heike Endepols, Aileen Jendro, Jens Konrad, Susan Vlachakis, Dirk Wiedermann, Michael Schroeter, Bernd Hoffmann, Rudolf Merkel, Niklas Marklund, Gereon R Fink, Maria A Rueger
Concussion, caused by a rotational acceleration/deceleration injury mild enough to avoid structural brain damage, is insufficiently captured in recent preclinical models, hampering the relation of pathophysiological findings on the cellular level to functional and behavioral deficits. We here describe a novel model of unrestrained, single vs. repetitive concussive brain injury (CBI) in male C56Bl/6j mice. Longitudinal behavioral assessments were conducted for up to seven days afterward, alongside the evaluation of structural cerebral integrity by in vivo magnetic resonance imaging (MRI, 9...
April 29, 2024: International Journal of Molecular Sciences
#4
REVIEW
Gustav Burström, Misha Amini, Victor Gabriel El-Hajj, Arooj Arfan, Maria Gharios, Ali Buwaider, Merle S Losch, Francesca Manni, Erik Edström, Adrian Elmi-Terander
Background: In brain tumor surgery, maximal tumor resection is typically desired. This is complicated by infiltrative tumor cells which cannot be visually distinguished from healthy brain tissue. Optical methods are an emerging field that can potentially revolutionize brain tumor surgery through intraoperative differentiation between healthy and tumor tissues. Methods: This study aimed to systematically explore and summarize the existing literature on the use of Raman Spectroscopy (RS), Hyperspectral Imaging (HSI), Optical Coherence Tomography (OCT), and Diffuse Reflectance Spectroscopy (DRS) for brain tumor detection...
May 2, 2024: Journal of Clinical Medicine
#5
JOURNAL ARTICLE
Lynn W Maines, Staci N Keller, Ryan A Smith, Randy S Schrecengost, Charles D Smith
Neuroblastoma (NB), the most common cancer in infants and the most common solid tumor outside the brain in children, grows aggressively and responds poorly to current therapies. We have identified a new drug (opaganib, also known as ABC294640) that modulates sphingolipid metabolism by inhibiting the synthesis of sphingosine 1-phosphate (S1P) by sphingosine kinase-2 and elevating dihydroceramides by inhibition of dihydroceramide desaturase. The present studies sought to determine the potential therapeutic activity of opaganib in cell culture and xenograft models of NB...
May 5, 2024: Cancers
#6
REVIEW
Anna Zanotto, Rebecca N Glover, Tobia Zanotto, Florien W Boele
Glioblastoma is the most common primary malignant brain tumor. While preliminary data point to the positive effects of rehabilitation for patients with glioblastoma, there are unique challenges for clinicians working with this population, including limited life expectancy and/or rapid neurological deterioration. The aim of this article is to review the literature on rehabilitation of adults with glioblastoma, including the feasibility of interventions, their effectiveness, as well as the current clinical practice...
April 27, 2024: Cancers
#7
JOURNAL ARTICLE
Lars André, Anders Björkelund, Ulf Ekelund, Tomas Vedin, Jonas Björk, Jakob Lundager Forberg
BACKGROUND: Current guidelines from Scandinavian Neuro Committee mandate a 24-hour observation for head trauma patients on anticoagulants, even with normal initial head CT scans, as a means not to miss delayed intracranial hemorrhages. This study aimed to assess the prevalence, and time to diagnosis, of clinically relevant delayed intracranial hemorrhage in head trauma patients treated with oral anticoagulants. METHOD: Utilizing comprehensive two-year data from Region Skåne's emergency departments, which serve a population of 1...
May 10, 2024: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
#8
JOURNAL ARTICLE
Alexander M Menzies, Georgina V Long, Amiee Kohn, Hussein Tawbi, Jeffrey Weber, Keith Flaherty, Grant A McArthur, Paolo A Ascierto, Yanina Pfluger, Karl Lewis, Katy K Tsai, Omid Hamid, Hans Prenen, Luis Fein, Erjian Wang, Carolin Guenzel, Fan Zhang, Joseph F Kleha, Alessandra di Pietro, Michael A Davies
BACKGROUND: POLARIS (phase 2 [ph2]; NCT03911869) evaluated encorafenib (BRAF inhibitor) in combination with binimetinib (MEK1/2 inhibitor) in BRAF/MEK inhibitor-naïve patients with BRAF V600-mutant melanoma with asymptomatic brain metastases. METHODS: The safety lead-in (SLI) assessed tolerability for high-dose encorafenib 300 mg twice daily (BID) plus binimetinib 45 mg BID. If the high dose was tolerable in ph2, patients would be randomized to receive high or standard dose (encorafenib 450 mg once daily [QD] plus binimetinib 45 mg BID)...
2024: Neuro-oncology advances
#9
JOURNAL ARTICLE
Erika G Marques de Menezes, Scott A Bowler, Cecilia M Shikuma, Lishomwa C Ndhlovu, Philip J Norris
BACKGROUND: Although effective antiretroviral therapy (ART) has improved the life expectancy of people with HIV (PWH), the prevalence of milder forms of HIV-associated neurocognitive disorders (HAND) persist, and it is associated with systemic and neuro-inflammatory processes that could impact other organ systems. However, the complex signaling mechanisms between the bone-kidney systems and the brain in HAND remain unknown. Extracellular vesicles (EVs) play a potential role in inter-organ communication and are involved in regulating cell activity in distant tissues...
2024: Frontiers in Neurology
#10
REVIEW
Karime Montes-Escobar, Javier de la Hoz-M, Paul Castillo-Cordova, Julia Patricia Duran-Ospina, Rosalba Karen Bravo-Saltos, German Josuet Lapo-Talledo, Aline Siteneski
Glioblastoma is a common and aggressive malignant central nervous system tumor in adults. This study aims to evaluate and analyze the scientific results, collaboration countries, main research topics, and topics over time reported about glioblastoma. A bibliometric analysis of glioblastoma publications was performed mainly using R and Multbiplot software for author, journal, and resume. Associated statistic methods Latent Dirichlet Allocation (LDA) and HJ-Biplot. Inclusion criteria were research articles from the PubMed database published in English between 1973 and December 2022...
May 10, 2024: Neurosurgical Review
#11
JOURNAL ARTICLE
Qinghui Sun, Zheng Wang, Hao Xiu, Na He, Mingyu Liu, Li Yin
Glioblastoma multiforme (GBM), the most aggressive form of primary brain tumor, poses a considerable challenge in neuro-oncology. Despite advancements in therapeutic approaches, the prognosis for GBM patients remains bleak, primarily attributed to its inherent resistance to conventional treatments and a high recurrence rate. The primary goal of this study was to acquire molecular insights into GBM by constructing a gene co-expression network, aiming to identify and predict key genes and signaling pathways associated with this challenging condition...
May 10, 2024: Scientific Reports
#12
REVIEW
Kuldeep Singh, Pranshul Sethi, Samaresh Datta, Jitendra Singh Chaudhary, Sunil Kumar, Divya Jain, Jeetendra Kumar Gupta, Shivendra Kumar, Ajay Guru, Siva Prasad Panda
Over the last three decades, neurodegenerative diseases (NDs) have increased in frequency. About 15% of the world's population suffers from NDs in some capacity, which causes cognitive and physical impairment. Neurodegenerative diseases, including Amyotrophic Lateral Sclerosis, Parkinson's disease, Alzheimer's disease, and others represent a significant and growing global health challenge. Neuroinflammation is recognized to be related to all NDs, even though NDs are caused by a complex mix of genetic, environmental, and lifestyle factors...
May 7, 2024: Ageing Research Reviews
#13
REVIEW
Lauren R Schaff, Maria Ioannou, Marjolein Geurts, Martin J van den Bent, Ingo K Mellinghoff, Karisa C Schreck
Low-grade gliomas present a formidable challenge in neuro-oncology because of the challenges imposed by the blood-brain barrier, predilection for the young adult population, and propensity for recurrence. In the past two decades, the systematic examination of genomic alterations in adults and children with primary brain tumors has uncovered profound new insights into the pathogenesis of these tumors, resulting in more accurate tumor classification and prognostication. It also identified several common recurrent genomic alterations that now define specific brain tumor subtypes and have provided a new opportunity for molecularly targeted therapeutic intervention...
June 2024: American Society of Clinical Oncology Educational Book
#14
JOURNAL ARTICLE
Ana Mirallave Pescador, José Pedro Lavrador, Arjel Lejarde, Cristina Bleil, Francesco Vergani, Alba Díaz Baamonde, Christos Soumpasis, Ranjeev Bhangoo, Ahilan Kailaya-Vasan, Christos M Tolias, Keyoumars Ashkan, Bassel Zebian, Jesús Requena Carrión
PURPOSE: To this day there is no consensus regarding evidence of usefulness of Intraoperative Neurophysiological Monitoring (IONM). Randomized controlled trials have not been performed in the past mainly because of difficulties in recruitment control subjects. In this study, we propose the use of Bayesian Networks to assess evidence in IONM. METHODS: Single center retrospective study from January 2020 to January 2022. Patients admitted for cranial neurosurgery with intraoperative neuromonitoring were enrolled...
May 9, 2024: Journal of Clinical Monitoring and Computing
#15
JOURNAL ARTICLE
Mengdie Li, Zhixiang Zhang, Liuguijie He, Xiefeng Wang, Jianxing Yin, Xiuxing Wang, Yongping You, Xu Qian, Xin Ge, Zhumei Shi
BACKGROUND: The high fatality rate of glioblastoma (GBM) is attributed to glioblastoma stem cells (GSCs), which exhibit heterogeneity and therapeutic resistance. Metabolic plasticity of mitochondria is the hallmark of GSCs. Targeting mitochondrial biogenesis of GSCs is crucial for improving clinical prognosis in GBM patients. METHODS: SMYD2-induced PGC1α methylation and followed nuclear export is confirmed by co-immunoprecipitation, cellular fractionation, and immunofluorescence...
May 9, 2024: Neuro-oncology
#16
JOURNAL ARTICLE
Felix Ehret, Daniel Rueß, Oliver Blanck, Susanne Fichte, Georgios Chatzikonstantinou, Robert Wolff, Lucas Mose, Stephan Mose, Thomas Fortmann, Ralph Lehrke, Menekse Turna, Hale Basak Caglar, Farshin Mortasawi, Martin Bleif, David Krug, Maximilian I Ruge, Christoph Fürweger, Alexander Muacevic
Brainstem metastases (BSM) present a significant neuro-oncological challenge, resulting in profound neurological deficits and poor survival outcomes. Stereotactic radiosurgery (SRS) and fractionated stereotactic radiotherapy (FSRT) offer promising therapeutic avenues for BSM despite their precarious location. This international multicenter study investigates the efficacy and safety of SRS and FSRT in 136 patients with 144 BSM treated at nine institutions from 2005 to 2022. The median radiographic and clinical follow-up periods were 6...
May 8, 2024: International Journal of Cancer. Journal International du Cancer
#17
(no author information available yet)
No abstract text is available yet for this article.
May 8, 2024: Neuro-oncology
#18
REVIEW
Habibullah Moradian, Tristan Gabriel, Mathilde Barrau, Xavier Roblin, Stéphane Paul
Links between the gut microbiota and human health have been supported throughout numerous studies, such as the development of neurological disease disorders. This link is referred to as the "microbiota-gut-brain axis" and is the focus of an emerging field of research. Microbial-derived metabolites and gut and neuro-immunological metabolites regulate this axis in health and many diseases. Indeed, assessing these signals, whether induced by microbial metabolites or neuro-immune mediators, could significantly increase our knowledge of the microbiota-gut-brain axis...
2024: Gut Microbes
#19
JOURNAL ARTICLE
Gunther Nussbaumer, Martin Benesch, Yura Grabovska, Alan Mackay, David Castel, Jacques Grill, Marta M Alonso, Manila Antonelli, Simon Bailey, Joshua N Baugh, Veronica Biassoni, Mirjam Blattner Johnson, Alberto Broniscer, Andrea Carai, Giovanna Stefania Colafati, Niclas Colditz, Selim Corbacioglu, Shauna Crampsie, Natacha Entz-Werle, Matthias Eyrich, Lea L Friker, Michael C Frühwald, Maria Luisa Garrè, Nicolas U Gerber, Felice Giangaspero, Maria J Gil-da-Costa, Norbert Graf, Darren Hargrave, Peter Hauser, Ulrich Herrlinger, Marion Hoffmann, Esther Hulleman, Elisa Izquierdo, Sandra Jacobs, Michael Karremann, Antonis Kattamis, Rejin Kebudi, Rolf-Dieter Kortmann, Robert Kwiecien, Maura Massimino, Angela Mastronuzzi, Evelina Miele, Giovanni Morana, Claudia M Noack, Virve Pentikainen, Thomas Perwein, Stefan M Pfister, Torsten Pietsch, Kleoniki Roka, Sabrina Rossi, Stefan Rutkowski, Elisabetta Schiavello, Clemens Seidel, Jaroslav Štěrba, Dominik Sturm, David Sumerauer, Anna Tacke, Sara Temelso, Chiara Valentini, Dannis van Vuurden, Pascale Varlet, Sophie E M Veldhuijzen van Zanten, Maria Vinci, André O von Bueren, Monika Warmuth-Metz, Pieter Wesseling, Maria Wiese, Johannes E A Wolff, Josef Zamecnik, Andrés Morales La Madrid, Brigitte Bison, Gerrit H Gielen, David T W Jones, Chris Jones, Christof M Kramm
BACKGROUND: The term Gliomatosis cerebri (GC), a radiology-defined highly infiltrating diffuse glioma, has been abandoned since molecular GC-associated features have not been established yet. METHODS: We conducted a multinational retrospective study of 104 children and adolescents with GC providing comprehensive clinical and (epi-)genetic characterization. RESULTS: Median overall survival (OS) was 15.5 months (interquartile range, 10.9-27...
May 8, 2024: Neuro-oncology
#20
JOURNAL ARTICLE
Cora Sophia Hummert, Lei Zhang, Gregor Schöner
Reaching movements generally show smooth kinematic profiles that are invariant across varying movement speeds even as interaction torques and muscle properties vary non-linearly with speed. How the brain brings about these invariant profiles is an open question.We develop an analytical inverse dynamics method to estimate descending activation patterns directly from observed joint angle trajectories based on a simple model of the stretch reflex, and of muscle and biomechanical dynamics. We estimate descending activation patterns for experimental data from eight different planar two-joint movements performed at two movement times (fast: 400 msec; slow: 800 msec)...
May 8, 2024: Journal of Neurophysiology
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