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https://www.readbyqxmd.com/read/28079156/a-mucin-like-peptide-from-fasciola-hepatica-instructs-dendritic-cells-with-parasite-specific-th1-polarizing-activity
#1
Verónica Noya, Natalie Brossard, Ernesto Rodríguez, L Sebastián Dergan-Dylon, Carlos Carmona, Gabriel A Rabinovich, Teresa Freire
Fasciolosis is a trematode zoonosis of interest in public health and cattle production. We report here the immunostimulatory effect of a 66 mer mucin-like peptide from Fasciola hepatica (Fhmuc), which synergizes with lipopolysaccharide (LPS) to promote dendritic cell (DC) maturation, endowing these cells with Th1-polarizing capacity. Exposure of DCs to Fhmuc in presence of LPS induced enhanced secretion of pro-inflammatory cytokines and expression of co-stimulatory molecules by DCs, promoting their T cell stimulatory capacity and selectively augmenting IFN-γ secretion by allogeneic T cells...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28076482/correlation-of-non-alcoholic-fatty-liver-disease-and-features-of-metabolic-syndrome-in-morbidly-obese-patients-in-the-preoperative-assessment-for-bariatric-surgery
#2
Fernando de Barros, Sergio Setúbal, José Manoel Martinho, Loraine Ferraz, Andressa Gaudêncio
Background: Obesity is an epidemic and chronic disease that can bring other comorbidities to the patient. Non-alcoholic fatty liver disease is present in up to 90% of these patients and can progress to hepatitis and hepatocarcinoma. The relationship of this liver disease and obesity is already well known; however, it is possible that some parameters of the comorbidities are more related than others in the pathophysiology of the disease. Aim: Was analyzed the relationship between non-alcoholic fatty liver disease (NAFLD) and the comorbidities of metabolic syndrome in morbidly obese patients...
November 2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/28076477/pediatric-liver-transplantation-with-ex-situ-liver-transection-and-the-application-of-the-human-fibrinogen-and-thrombin-sponge-in-the-wound-area
#3
Fernando Pompeu Piza Vicentine, Adriano Miziara Gonzalez, Ramiro Anthero de Azevedo, Barbara Burza Benini, Marcelo Moura Linhares, Gaspar de Jesus Lopes-Filho, Jose Luiz Martins, Alcides Augusto Salzedas-Netto
Background: Surgical strategy to increase the number of liver transplants in the pediatric population is the ex-situ liver transection (reduction or split). However, it is associated with complications such as hemorrhage and leaks. The human fibrinogen and thrombin sponge is useful for improving hemostasis in liver surgery. Aim: Compare pediatric liver transplants with ex-situ liver transection (reduction or split) with or without the human fibrinogen and thrombin sponge...
November 2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/28060841/genomes-of-fasciola-hepatica-from-the-americas-reveal-colonization-with-neorickettsia-endobacteria-related-to-the-agents-of-potomac-horse-and-human-sennetsu-fevers
#4
Samantha N McNulty, Jose F Tort, Gabriel Rinaldi, Kerstin Fischer, Bruce A Rosa, Pablo Smircich, Santiago Fontenla, Young-Jun Choi, Rahul Tyagi, Kymberlie Hallsworth-Pepin, Victoria H Mann, Lakshmi Kammili, Patricia S Latham, Nicolas Dell'Oca, Fernanda Dominguez, Carlos Carmona, Peter U Fischer, Paul J Brindley, Makedonka Mitreva
Food borne trematodes (FBTs) are an assemblage of platyhelminth parasites transmitted through the food chain, four of which are recognized as neglected tropical diseases (NTDs). Fascioliasis stands out among the other NTDs due to its broad and significant impact on both human and animal health, as Fasciola sp., are also considered major pathogens of domestic ruminants. Here we present a reference genome sequence of the common liver fluke, Fasciola hepatica isolated from sheep, complementing previously reported isolate from cattle...
January 6, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28032880/hepatitis-isqu%C3%A3-mica-secundaria-a-taponamiento-cardiaco-una-causa-poco-frecuente
#5
S Goñi Esarte, J M Zozaya Urmeneta, M Goñi Esarte, J I Uriz Otano, I Idoate Santesteban, M T Beunza Puyol
La hepatitis isquémica es una entidad poco frecuente. Se asocia a una hipoperfusión hepática debida en primer lugar a un bajo gasto cardíaco (insuficiencia cardiaca congestiva, infarto agudo de miocardio o miocardiopatía dilatada). De forma menos frecuente puede ser secundaria a una insuficiencia respiratoria o al aumento de las necesidades de oxígeno en el contexto de una sepsis.Paciente varón de 49 años que acude al servicio de Urgencias por disnea progresiva e hipotensión, objetivándose una importante elevación de transaminasas (aspartato aminotransferasa de 5...
December 30, 2016: Anales del Sistema Sanitario de Navarra
https://www.readbyqxmd.com/read/28026895/self-fertilization-long-distance-flash-invasion-and-biogeography-shape-the-population-structure-of-pseudosuccinea-columella-at-the-worldwide-scale
#6
M Lounnas, A C Correa, A A Vázquez, A Dia, J S Escobar, A Nicot, J Arenas, R Ayaqui, M P Dubois, T Gimenez, A Gutiérrez, C González-Ramírez, O Noya, L Prepelitchi, N Uribe, C Wisnivesky-Colli, M Yong, P David, E S Loker, P Jarne, J P Pointier, S Hurtrez-Boussès
Population genetic studies are efficient for inferring the invasion history based on a comparison of native and invasive populations, especially when conducted at species scale. An expected outcome in invasive populations is variability loss, and this is especially true in self-fertilizing species. We here focus on the self-fertilizing Pseudosuccinea columella, an invasive hermaphroditic freshwater snail that has greatly expanded its geographic distribution and that acts as intermediate host of Fasciola hepatica, the causative agent of human and veterinary fasciolosis...
December 27, 2016: Molecular Ecology
https://www.readbyqxmd.com/read/28004280/genetic-structure-of-hepatica-nobilis-var-japonica-focusing-on-within-population-flower-color-polymorphism
#7
Shinichiro Kameoka, Hitoshi Sakio, Harue Abe, Hajime Ikeda, Hiroaki Setoguchi
How phenotypic or genetic diversity is maintained in a natural habitat is a fundamental question in evolutionary biology. Flower color polymorphism in plants is a common polymorphism. Hepatica nobilis var. japonica on the Sea of Japan (SJ) side of the Japanese mainland exhibits within population flower color polymorphism (e.g., white, pink, and purple), while only white flowers are observed on the Pacific Ocean (PO) side. To determine the relationships between flower color polymorphism, within and among populations, and the genetic structure of H...
December 21, 2016: Journal of Plant Research
https://www.readbyqxmd.com/read/28000591/relative-importance-of-meteorological-and-geographical-factors-in-the-distribution-of-fasciola-hepatica-infestation-in-farmed-sheep-in-qinghai-province-china
#8
Hongyu Qin, Xiang Gao, Hongbin Wang, Jianhua Xiao
Fasciola hepatica is an important trematode parasite of economic importance that infests sheep and cattle worldwide. We conducted a detailed investigation into the spatial distribution of F. hepatica infestation in farmed sheep in Qinghai (Wutumeiren) province, Mainland China. Mathematical modelling was used to assess the inter-relationships between meteorological and geographical factors and the risk of F. hepatica infestation across the province. A capture enzyme-linked immunosorbent assay (ELISA) test (MM3-SERO) was used to detect F...
2016: Parasite: Journal de la Société Française de Parasitologie
https://www.readbyqxmd.com/read/27982337/right-hepatic-artery-aneurysm
#9
Astrid Del Pilar Ardila Bernal, Paulo Loures, Juan Cristóbal Ospina Calle, Beatriz Cunha, Juan Camilo Córdoba
We report a case of an aneurysm of the right hepatic artery and its multidisciplinary management by general surgery, endoscopy and radiology services. Being a case of extremely low incidence, it is important to show its diagnostic and therapeutic approach. RESUMO Relatamos um caso de aneurisma da artéria hepática direita conduzido de forma multidisciplinar pelos Serviços de Cirurgia Geral, Endoscopia e Radiologia. Em se tratando de caso de incidência baixíssima, é importante mostrar o enfoque diagnóstico e terapêutico usado em seu manejo...
September 2016: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/27982334/modified-technique-for-preparation-of-venous-circulation-resin-casts-in-the-cirrhotic-liver
#10
José Olímpio Maia DE Vasconcelos, Laécio Leitão Batista, Guilherme Benjamin Brandão Pitta, Cláudio Moura Lacerda
This study describes two major adaptations for the preparation of resin casts in human cirrhotic liver, harvested at the time of transplantation. The first is the way of fixing the catheter in the ostia of the hepatic and portal veins through a cerclage, so as to prevent displacement of the catheter and / or leakage of the resin during its injection. The second is the extension of corrosion time in the NaOH solution, averaging 6.8 days, with daily replacement the solution until complete removal of parenchymal tissue...
September 2016: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/27957438/molecular-characterization-of-animal-fasciola-spp-isolates-from-kermanshah-western-iran
#11
Arezoo Bozorgomid, Naser Nazari, Hamzeh Rahimi, Eshrat Beigom Kia, Homa Hajjaran, Mehdi Mohebali, Mojgan Aryaeipour, Peyman Heidarian, Mohammad Saeid Ezati, Mohamad Bagher Rokni
BACKGROUND: We evaluated the genetic diversity of samples identified morphologically as Fasciola spp. from sheep, cattle and goat from Kermanshah Province, western Iran using PCR-RFLP method. METHODS: We used PCR-RFLP analysis of ribosomal ITS1 fragment using RsaI restriction enzyme to investigate the genetic characteristics of Fasciola species obtained from different hosts (16 sheep, 28 cattle, 4 goats). The species of Fasciola were confirmed by sequencing the 700 bp region of ribosomal ITS1 gene...
October 2016: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/27940066/fasciola-hepatica-demonstrates-high-levels-of-genetic-diversity-a-lack-of-population-structure-and-high-gene-flow-possible-implications-for-drug-resistance
#12
Nicola J Beesley, Diana J L Williams, Steve Paterson, Jane Hodgkinson
Fasciola hepatica, the liver fluke, is a trematode parasite of considerable economic importance to the livestock industry and is a re-emerging zoonosis that poses a risk to human health in F. hepatica-endemic areas worldwide. Drug resistance is a substantial threat to the current and future control of F. hepatica, yet little is known about how the biology of the parasite influences the development and spread of resistance. Given that F. hepatica can self-fertilise and therefore inbreed, there is the potential for greater population differentiation and an increased likelihood of recessive alleles, such as drug resistance genes, coming together...
December 7, 2016: International Journal for Parasitology
https://www.readbyqxmd.com/read/27906040/identity-of-fasciola-spp-in-sheep-in-egypt
#13
Said Amer, Ahmed ElKhatam, Shereif Zidan, Yaoyu Feng, Lihua Xiao
BACKGROUND: In Egypt, liver flukes, Fasciola spp. (Digenea: Fasciolidae), have a serious impact on the farming industry and public health. Both Fasciola hepatica and Fasciola gigantica are known to occur in cattle, providing the opportunity for genetic recombination. Little is known on the identity and genetic variability of Fasciola populations in sheep. METHODS: This study was performed to determine the prevalence of liver flukes in sheep in Menofia Province as a representative area of the delta region in Egypt, as measured by postmortem examination of slaughtered animals at three abattoirs...
December 1, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27894356/transmission-of-calicophoron-daubneyi-and-fasciola-hepatica-in-galicia-spain-temporal-follow-up-in-the-intermediate-and-definitive-hosts
#14
Javier Iglesias-Piñeiro, Marta González-Warleta, José Antonio Castro-Hermida, María Córdoba, Camino González-Lanza, Yolanda Manga-González, Mercedes Mezo
BACKGROUND: Paramphistomosis caused by Calicophoron daubneyi and fasciolosis caused by Fasciola hepatica are common parasitic diseases of livestock animals. Transmission of the diseases depends on the presence of intermediate hosts, i.e. freshwater gastropods such as lymnaeids. We carried out a 2-year-long study of the dynamics of the snail population acting as the intermediate host for these parasites, considering the population structure in terms of size/age and infection status. In addition, we determined the kinetics of trematode egg excretion in grazing cows...
November 29, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27890084/comparison-of-molecular-and-conventional-methods-for-the-diagnosis-of-fasciola-hepatica-infection-in-the-field
#15
COMPARATIVE STUDY
Maria Immaculata Arifin, Johan Höglund, Adam Novobilský
The liver fluke, Fasciola hepatica, is one of the major parasite threats to livestock industries world-wide. In sheep and cattle, F. hepatica infection is commonly diagnosed using a range of methods. Aside from conventional coprological and serological diagnostic methods, there are also several molecular methods available based on the detection of liver fluke DNA in faeces. In this study, the outcomes of faecal egg count (FEC), serology and coproantigen ELISA (cELISA) were compared with the performance of polymerase chain reaction (PCR) and loop-mediated isothermal amplification (LAMP) in diagnosis of F...
December 15, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/27890078/animal-fascioliasis-perspectives-from-high-altitudinal-regions
#16
Damanbha Lyngdoh, Sunil Sharma, Bishnupada Roy, Veena Tandon
The parasitic flukes of the genus Fasciola (Platyhelminthes: Trematoda: Digenea) cause fascioliasis or liver-rot disease in ruminant livestock in tropical and sub-tropical regions of the world. Classically, two species of Fasciola- F. hepatica and F. gigantica, are universally recognized as taxonomically valid species. Our survey studies on ovid and bovid animals including yak and mithun from high altitudinal mountainous regions in Northeast India revealed the occurrence of Fasciola gigantica and also Fasciola sp...
December 15, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/27884436/distribution-of-foxp3-t-cells-in-the-liver-and-hepatic-lymph-nodes-of-goats-and-sheep-experimentally-infected-with-fasciola-hepatica
#17
A Escamilla, R Zafra, J Pérez, T N McNeilly, I L Pacheco, L Buffoni, F J Martínez-Moreno, V Molina-Hernández, A Martínez-Moreno
Foxp3 regulatory T cells (Tregs) are now considered to play a key role in modulation of immune responses during parasitic helminth infections. Immunomodulation is a key factor in Fasciola hepatica infection; however, the distribution and role of Foxp3(+) Tregs cells have not been investigated in F. hepatica infected ruminants. The aim of this study was to evaluate the presence of Foxp3(+) Tregs in the liver and hepatic lymph nodes from experimentally infected sheep and goats during acute and chronic stages of infection...
October 30, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/27883079/a-parasite-derived-68-mer-peptide-ameliorates-autoimmune-disease-in-murine-models-of-type-1-diabetes-and-multiple-sclerosis
#18
Maria E Lund, Judith Greer, Aakanksha Dixit, Raquel Alvarado, Padraig McCauley-Winter, Joyce To, Akane Tanaka, Andrew T Hutchinson, Mark W Robinson, Ann M Simpson, Bronwyn A O'Brien, John P Dalton, Sheila Donnelly
Helminth parasites secrete molecules that potently modulate the immune responses of their hosts and, therefore, have potential for the treatment of immune-mediated human diseases. FhHDM-1, a 68-mer peptide secreted by the helminth parasite Fasciola hepatica, ameliorated disease in two different murine models of autoimmunity, type 1 diabetes and relapsing-remitting immune-mediated demyelination. Unexpectedly, FhHDM-1 treatment did not affect the proliferation of auto-antigen specific T cells or their production of cytokines...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27876981/detection-of-fasciola-hepatica-and-fasciola-gigantica-common-and-uncommon-antigens-using-rabbit-hyper-immune-serum-raised-against-their-excretory-secretory-and-somatic-antigens
#19
S Abdolahi Khabisi, B Sarkari
Fasciolosis is an important neglected helminth disease caused by two liver flukes, Fasciola hepatica and Fasciola gigantica. The two species of Fasciola are usually different in their morphological and molecular features. They have also common and uncommon antigens in both their somatic and excretory secretory metabolites. In this study, we compared somatic and excretory-secretory (ES) antigens of F. hepatica and F. gigantica, by using rabbit hyper immune serum raised against these antigens. Adult worms were collected from bile ducts of infected animals and species of the fluke was confirmed by RFLP-PCR...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27876964/patho-physiological-observations-in-natural-concurrent-infections-of-helminth-parasites-of-zoonotic-importance-in-the-wild-rodents-bandicota-bengalensis
#20
N Singla, P Dhar, L D Singla, K Gupta
Screening of 83 mature wild rodents of Bandicota bengalensis (52 male and 31 females), live trapped from premises near railway station, fish market and agricultural fields in Ludhiana district of Punjab province, India was carried out to assess the natural occurrence of helminth parasites and their potential as reservoirs of zoonoses. On necropsy, intestine of rats was found infected with adult cestode parasites of Hymenolepis diminuta and H. nana. Liver was found infected with Capillaria hepatica and Cysticercus fasciolaris...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
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