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https://www.readbyqxmd.com/read/29665814/herd-level-seroprevalence-of-fasciola-hepatica-and-ostertagia-ostertagi-infection-in-dairy-cattle-population-in-the-central-and-northeastern-poland
#1
Sławomir J Kowalczyk, Michał Czopowicz, Corinna N Weber, Elisabeth Müller, Tomasz Nalbert, Andrzej Bereznowski, Jarosław Kaba
BACKGROUND: Fasciola hepatica and Ostertagia ostertagi infections are widespread in cattle population of Europe, however data on their prevalence in Poland are only fragmentary. Therefore, the cross-sectional study was carried out to determine the herd-level seroprevalence of F. hepatica and O. ostertagi infection in dairy cattle population in the central and north-eastern provinces Poland, and to identify basic local risk factors for these infections. In total, 598 herds were enrolled, 394 (65...
April 17, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29657001/accuracy-of-a-diagnostic-model-based-on-serum-biochemical-parameters-in-detecting-cows-at-an-increased-risk-of-chronic-fascioliasis
#2
Sławomir J Kowalczyk, Michał Czopowicz, Corinna N Weber, Elisabeth Müller, Jarosław Kaba
In adult cattle Fasciola hepatica infection usually follows a chronic subclinical course, and reduces both the milk yield and milk quality, resulting in considerable financial losses. Effective control of the disease is based on reliable identification of asymptomatically infected individuals, which now requires special parasitological or serological diagnostic tests. It is also known that F. hepatica infection induces alterations in some serum biochemical parameters. Therefore, the study was conducted to develop a model based on serum biochemical parameters allowing to identify cows at higher risk of chronic fascioliasis...
April 30, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29604994/a-new-method-for-laboratory-rearing-of-galba-truncatula-the-intermediate-host-of-fasciola-hepatica
#3
Mohammad Moazeni, Amin Ahmadi, Amir Mootabi Alavi
In this study a relatively large and open top aquarium was designed, constructed and introduced as a suitable habitat for nutrition, growth and development as well as for egg laying and breeding of Galba truncatula under laboratory conditions. The soil and water used in the aquarium were collected from the locality in which the snails were collected. The aquarium was placed in a laboratory with temperature of 18-32 ºC and relative humidity of 22-37% respectively, according to the season. The artificial light was controlled by a light timer, giving 12 h of light and 12 h of darkness...
April 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29601965/high-yield-production-of-human-invariant-chain-cd74-constructs-fused-to-solubility-enhancing-peptides-and-characterization-of-their-mif-binding-capacities
#4
Tjie Kok, Anna A Wasiel, Frank J Dekker, Gerrit J Poelarends, Robbert H Cool
The HLA class II histocompatibility antigen gamma chain, also known as HLA-DR antigen-associated invariant chain or CD74, has been shown to be involved in many biological processes amongst which antigen loading and transport of MHC class II molecules from the endoplasmic reticulum to the Golgi complex. It is also part of a receptor complex for Macrophage Migration Inhibitory Factor (MIF), and participates in inflammatory signaling. The inhibition of MIF-CD74 complex formation is regarded as a potentially attractive therapeutic target in inflammation, cancer and immune diseases...
March 27, 2018: Protein Expression and Purification
https://www.readbyqxmd.com/read/29593895/cross-sectional-serological-survey-of-human-fascioliasis-in-canutama-municipality-in-western-amazon-brazil
#5
Marcel Gonçalves Maciel, Walter Dos Santos Lima, Francisco Lazaro Moreira de Almeida, Leila Inês Aguiar Raposo Câmara Coelho, Guilherme Alfredo Novelino Araújo, Mariana Gomes Lima, Luiz Henrique Gonçalves Maciel, Cíntia Aparecida de Jesus Pereira, Thaís Costa da Silva Maciel, Jorge Augusto de Oliveira Guerra, Rosa Amélia Gonçalves Santana, Maria das Graças Vale Barbosa Guerra
Background: Fascioliasis is an important parasitic disease. In the northern region of Brazil, a human parasite infection has been reported through a coprological survey. Eggs of Fasciola hepatica were found in fecal samples of 11 individuals. Knowledge of the infection in animals or the presence of snails is necessary to address the possibility of the parasite cycle occurrence in that region. The aim of this study was to describe the transmission of human fascioliasis in Canutama, Amazonas, in Western Amazonia, Brazil...
2018: Journal of Parasitology Research
https://www.readbyqxmd.com/read/29565175/-anorexia-nervosa-as-a-cause-of-acute-liver-failure-report-of-a-case
#6
Beatriz Voltas-Arribas, Ana Artero-Fullana, Juan Carlos Ferrer-García, Carlos Sánchez-Juan, Cristian Marco-Alacid, Pablo Sanz-Revert, Lourdes García-Blasco
Caso clínico: presentamos una paciente de 33 años con anorexia nerviosa de 15 años de evolución con uno de los pocos casos reportados de fallo hepático agudo severo secundario a la desnutrición.Discusión: tras el soporte nutricional protocolizado para evitar el síndrome de realimentación y un adecuado manejo multidisciplinar, la paciente evoluciona favorablemente logrando normalizar los electrolitos, la función hepática y las alteraciones en la coagulación.
January 10, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29564626/comparison-of-recombinant-cathepsins-l1-l2-and-l5-as-elisa-targets-for-serodiagnosis-of-bovine-and-ovine-fascioliasis
#7
Victoria Martínez-Sernández, María J Perteguer, Ana Hernández-González, Mercedes Mezo, Marta González-Warleta, Ricardo A Orbegozo-Medina, Fernanda Romarís, Esperanza Paniagua, Teresa Gárate, Florencio M Ubeira
Infections caused by Fasciola hepatica are of great importance in the veterinary field, as they cause important economic losses to livestock producers. Serodiagnostic methods, typically ELISA (with either native or recombinant antigens), are often used for early diagnosis. The use of native antigens, as in the MM3-SERO ELISA (commercialized as BIO K 211, BIO-X Diagnostics), continues to be beneficial in terms of sensitivity and specificity; however, there is interest in developing ELISA tests based on recombinant antigens to avoid the need to culture parasites...
March 21, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29525755/neoadjuvant-chemotherapy-or-primary-debulking-surgery-in-figo-iiic-and-iv-patients-results-from-a-survey-study-in-the-netherlands
#8
M Timmermans, G S Sonke, W J van Driel, R I Lalisang, P B Ottevanger, C D de Kroon, K K Van de Vijver, M A van der Aa, R F Kruitwagen
INTRODUCTION: Primary debulking surgery (PDS) followed by adjuvant chemotherapy is historically recommended as first line treatment for advanced stage ovarian cancer. Two randomized controlled trials, however, showed similar efficacy and reduced toxicity with neoadjuvant chemotherapy followed by interval debulking surgery (NACT-IDS). Nevertheless, uptake of NACT-IDS varies widely between hospitals, which cannot be explained by difference in patient populations. In this survey, we therefore aimed to evaluate the views on NACT-IDS among all Dutch gynaecologists and medical oncologists involved in the treatment of ovarian cancer...
April 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29525280/vaccination-of-sheep-with-quil-a%C3%A2-adjuvant-expands-the-antibody-repertoire-to-the-fasciola-mf6p-fhhdm-1-antigen-and-administered-together-impair-the-growth-and-antigen-release-of-flukes
#9
Ricardo A Orbegozo-Medina, Victoria Martínez-Sernández, Marta González-Warleta, José Antonio Castro-Hermida, Mercedes Mezo, Florencio M Ubeira
Fasciolosis continues to be a major cause of economic losses in the livestock industry and a growing threat to humans. The limited spectrum of effective anthelmintics and the appearance of resistances urge the need for developing an effective vaccine. Most studies have been focused on the use of TH1 -polarizing adjuvants and the use of recombinant Fasciola critical molecules and, despite the efforts, no reproducible protections have been achieved. The F. hepatica MF6p/FhHDM-1 protein is a heme-binding protein also reported to have immunomodulatory properties, constituting a promising target for vaccination and/or as target for the development of new flukicides...
March 8, 2018: Vaccine
https://www.readbyqxmd.com/read/29519265/seasonality-of-helminth-infection-in-wild-red-deer-varies-between-individuals-and-between-parasite-taxa
#10
Gregory F Albery, Fiona Kenyon, Alison Morris, Sean Morris, Daniel H Nussey, Josephine M Pemberton
Parasitism in wild mammals can vary according to myriad intrinsic and extrinsic factors, many of which vary seasonally. However, seasonal variation in parasitism is rarely studied using repeated samples from known individuals. Here we used a wild population of individually recognized red deer (Cervus elaphus) on the Isle of Rum to quantify seasonality and intrinsic factors affecting gastrointestinal helminth parasitism over the course of a year. We collected 1020 non-invasive faecal samples from 328 known individuals which we then analysed for propagules of three helminth taxa: strongyle nematodes, the common liver fluke Fasciola hepatica and the tissue nematode Elaphostrongylus cervi...
March 9, 2018: Parasitology
https://www.readbyqxmd.com/read/29510740/a-recombinant-fasciola-gigantica-14-3-3-epsilon-protein-rfg14-3-3e-modulates-various-functions-of-goat-peripheral-blood-mononuclear-cells
#11
Ai-Ling Tian, MingMin Lu, Guillermo Calderón-Mantilla, Evangelia Petsalaki, Tania Dottorini, XiaoWei Tian, YuJian Wang, Si-Yang Huang, Jun-Ling Hou, XiangRui Li, Hany M Elsheikha, Xing-Quan Zhu
BACKGROUND: The molecular structure of Fasciola gigantica 14-3-3 protein has been characterized. However, the involvement of this protein in parasite pathogenesis remains elusive and its effect on the functions of innate immune cells is unknown. We report on the cloning and expression of a recombinant F. gigantica 14-3-3 epsilon protein (rFg14-3-3e), and testing its effects on specific functions of goat peripheral blood mononuclear cells (PBMCs). METHODS: rFg14-3-3e protein was expressed in Pichia pastoris...
March 6, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29476869/advances-in-fasciola-hepatica-research-using-omics-technologies
#12
REVIEW
Krystyna Cwiklinski, John P Dalton
The liver fluke Fasciola hepatica is an economically important pathogen of livestock worldwide, as well as being an important neglected zoonosis. Parasite control is reliant on the use of drugs, particularly triclabendazole, which is effective against multiple parasite stages. However, the spread of parasites resistant to triclabendazole has intensified the pursuit for novel control strategies. Emerging - omic technologies are helping advance our understanding of liver fluke biology, specifically the molecules that act at the host-parasite interface and are central to infection, virulence and long-term survival within the definitive host...
February 21, 2018: International Journal for Parasitology
https://www.readbyqxmd.com/read/29474932/profiling-g-protein-coupled-receptors-of-fasciola-hepatica-identifies-orphan-rhodopsins-unique-to-phylum-platyhelminthes
#13
Paul McVeigh, Erin McCammick, Paul McCusker, Duncan Wells, Jane Hodgkinson, Steve Paterson, Angela Mousley, Nikki J Marks, Aaron G Maule
G protein-coupled receptors (GPCRs) are established drug targets. Despite their considerable appeal as targets for next-generation anthelmintics, poor understanding of their diversity and function in parasitic helminths has thwarted progress towards GPCR-targeted anti-parasite drugs. This study facilitates GPCR research in the liver fluke, Fasciola hepatica, by generating the first profile of GPCRs from the F. hepatica genome. Our dataset describes 147 high confidence GPCRs, representing the largest cohort of GPCRs, and the largest set of in silico ligand-receptor predictions, yet reported in any parasitic helminth...
February 5, 2018: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29426482/comparison-of-early-detection-of-fasciola-hepatica-in-experimentally-infected-merino-sheep-by-real-time-pcr-coproantigen-elisa-and-sedimentation
#14
Nichola Eliza Davies Calvani, Sarah Deanna George, Peter Andrew Windsor, Russell David Bush, Jan Šlapeta
Fasciolosis due to infection with Fasciola hepatica, Fasciola gigantica or their hybrids is a significant global cause of livestock production loss. Infection is commonly diagnosed by a labour-intensive sedimentation and faecal egg count (FEC), which has limited throughput and is only applicable after completion of the 8-12 week pre-patent period (PPP). A commercially-available ELISA for the detection of coprological antigen (coproELISA) enables detection prior to the completion of the PPP and is suitable for diagnosis of larger sample sizes, although the sensitivity reported under experimental infection settings can be difficult to replicate in the field, particularly in cattle...
February 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29426464/a-new-multiplex-pcr-assay-to-distinguish-among-three-cryptic-galba-species-intermediate-hosts-of-fasciola-hepatica
#15
Pilar Alda, Manon Lounnas, Antonio Alejandro Vázquez, Rolando Ayaqui, Manuel Calvopiña, Maritza Celi-Erazo, Robert T Dillon, Philippe Jarne, Eric S Loker, Flavia Caroll Muñiz Pareja, Jenny Muzzio-Aroca, Alberto Orlando Nárvaez, Oscar Noya, Luiggi Martini Robles, Richar Rodríguez-Hidalgo, Nelson Uribe, Patrice David, Jean-Pierre Pointier, Sylvie Hurtrez-Boussès
A molecular tool described here allows in one step for specific discrimination among three cryptic freshwater snail species (genus Galba) involved in fasciolosis transmission, a worldwide infectious disease of humans and livestock. The multiplex PCR approach taken targets for each species a distinctive, known microsatellite locus which is amplified using specific primers designed to generate an amplicon of a distinctive size that can be readily separated from the amplicons of the other two species on an agarose gel...
February 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29414671/fibrinogen-and-fibrin-are-novel-substrates-for-fasciola-hepatica-cathepsin-l-peptidases
#16
Mirjam M Mebius, Jody M J Op Heij, Aloysius G M Tielens, Philip G de Groot, Rolf T Urbanus, Jaap J van Hellemond
Cathepsin peptidases form a major component of the secreted proteins of the blood-feeding trematodes Fasciola hepatica and Schistosoma mansoni. These peptidases fulfill many functions, from facilitating infection to feeding and immune evasion. In this study, we examined the Fasciola cathepsin L peptidases FhCL1, FhCL2, and FhCL3 and the schistosomal cathepsin peptidases SmCB1 and SmCL3 for their anticoagulant properties. Although no direct anticoagulant effect of these peptidases was observed, we discovered that cathepsin peptidases from Fasciola, but not from Schistosoma, were able to degrade purified fibrinogen, with FhCL1 having the highest fibrinogenolytic activity...
February 4, 2018: Molecular and Biochemical Parasitology
https://www.readbyqxmd.com/read/29409966/fasciola-hepatica-convoluted-life-forms-and-names
#17
Dieter Stürchler
No abstract text is available yet for this article.
January 31, 2018: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29406086/co-infection-with-fasciola-hepatica-may-increase-the-risk-of-escherichia-coli-o157-shedding-in-british-cattle-destined-for-the-food-chain
#18
Alison K Howell, Sue C Tongue, Carol Currie, Judith Evans, Diana J L Williams, Tom N McNeilly
Escherichia coli O157 is a zoonotic bacterium that can cause haemorrhagic diarrhoea in humans and is of worldwide public health concern. Cattle are considered to be the main reservoir for human infection. Fasciola hepatica is a globally important parasite of ruminant livestock that is known to modulate its host's immune response and affect susceptibility to bacterial pathogens such as Salmonella Dublin. Shedding of E. coli O157 is triggered by unknown events, but the immune system is thought to play a part...
February 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29385479/genetic-correlations-between-endo-parasite-phenotypes-and-economically-important-traits-in-dairy-and-beef-cattle
#19
A J Twomey, R I Carroll, M L Doherty, N Byrne, D A Graham, R G Sayers, A Blom, D P Berry
Parasitic diseases have economic consequences in cattle production systems. Although breeding for parasite resistance can complement current control practices to reduce the prevalence globally, there is little knowledge of the implications of such a strategy on other performance traits. Records on individual animal antibody responses to Fasciola hepatica, Ostertagia ostertagi and Neospora caninum were available from cows in 68 dairy herds (study herds); national abattoir data on F. hepatica-damaged livers were also available from dairy and beef cattle...
January 29, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29373193/antibody-recognition-of-cathepsin-l1-derived-peptides-in-fasciola-hepatica-infected-and-or-vaccinated-cattle-and-identification-of-protective-linear-b-cell-epitopes
#20
Laura Garza-Cuartero, Thomas Geurden, Suman M Mahan, John M Hardham, John P Dalton, Grace Mulcahy
Fasciola hepatica infection causes important economic losses in livestock and food industries around the world. In the Republic of Ireland F. hepatica infection has an 76% prevalence in cattle. Due to the increase of anti-helminthic resistance, a vaccine-based approach to control of Fasciolosis is urgently needed. A recombinant version of the cysteine protease cathepsin L1 (rmFhCL1) from F. hepatica has been a vaccine candidate for many years. We have found that vaccination of cattle with this immunodominant antigen has provided protection against infection in some experimental trials, but not in others...
January 17, 2018: Vaccine
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