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Nicotine dependence

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https://www.readbyqxmd.com/read/28231626/default-mode-network-deactivation-to-smoking-cue-relative-to-food-cue-predicts-treatment-outcome-in-nicotine-use-disorder
#1
Claire E Wilcox, Eric D Claus, Vince D Calhoun, Srinivas Rachakonda, Rae A Littlewood, Jessica Mickey, Pamela B Arenella, Natalie Goodreau, Kent E Hutchison
Identifying predictors of treatment outcome for nicotine use disorders (NUDs) may help improve efficacy of established treatments, like varenicline. Brain reactivity to drug stimuli predicts relapse risk in nicotine and other substance use disorders in some studies. Activity in the default mode network (DMN) is affected by drug cues and other palatable cues, but its clinical significance is unclear. In this study, 143 individuals with NUD (male n = 91, ages 18-55 years) received a functional magnetic resonance imaging scan during a visual cue task during which they were presented with a series of smoking-related or food-related video clips prior to randomization to treatment with varenicline (n = 80) or placebo...
February 23, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28217868/an-anti-nicotinic-cognitive-challenge-model-using-mecamylamine-in-comparison-with-the-anti-muscarinic-cognitive-challenge-using-scopolamine
#2
A C Baakman, R Alvarez-Jimenez, R Rissmann, E S Klaassen, J Stevens, S C Goulooze, J Burger, E L Swart, J M A van Gerven, G J Groeneveld
INTRODUCTION: The muscarinic acetylcholine receptor antagonist scopolamine is often used for proof-of-pharmacology studies with pro-cognitive compounds. From a pharmacological point of view, it would seem more rational to use a nicotinic rather than a muscarinic anticholinergic challenge to prove pharmacology of a nicotinic acetylcholine receptor agonist. This study aims to characterize a nicotinic anticholinergic challenge model using mecamylamine and to compare it to the scopolamine model...
February 20, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28216497/-visual-evoked-functional-connectivity-before-and-after-smoking-cessation-based-on-functional-magnetic-resonance-imaging
#3
Shaofeng Mo, Xiaokai Zhang, Hongbo Chen, Jingtian Tang
To explore differences in visual information processing for smoking addicts between before and after smoking cessation based on functional magnetic resonance imaging technology.
 Methods: Seventeen volunteers, with heavy dependence on nicotine, agreed to give up smoking and to complete the test. The primary visual network and secondary visual network were extracted by independent component analysis technology. The region of interest was defined as the region with significant difference between before and after smoking cessation...
January 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28214708/evaluating-the-role-of-smokeless-tobacco-use-indices-as-brief-measures-of-dependence
#4
Nasir Mushtaq, Laura A Beebe
INTRODUCTION: There is considerable interest in using brief measures of dependence for evaluation and treatment of tobacco dependence. The Heaviness of Smoking Index (HSI) is a validated measure of dependence among cigarette smokers. However, a similar index has not been studied among ST users. The aim of this study is to develop similar ST use indices and evaluate their utility as concise dependence measures. Time to first chew/dip of the day (TTFD), number of cans of ST used per week (CPW), and number of dips/chews per day (DPD) were used to create three ST use indices; heaviness of ST use index (HSTI), ST dependence index (STDI), and ST quantity frequency index (ST-QFI)...
February 10, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28213124/reciprocal-relationships-between-substance-use-and-disorders-and-suicidal-ideation-and-suicide-attempts-in-the-collaborative-study-of-the-genetics-of-alcoholism
#5
Arpana Agrawal, Rebecca Tillman, Richard A Grucza, Elliot C Nelson, Vivia V McCutcheon, Lauren Few, Kenneth R Conner, Michael T Lynskey, Danielle M Dick, Howard J Edenberg, Victor M Hesselbrock, John R Kramer, Samuel Kuperman, John I Nurnberger, Marc A Schuckit, Bernice Porjesz, Kathleen K Bucholz
BACKGROUND: Substance use and misuse and suicidal thoughts and behaviors tend to co-occur. The purpose of this study was to examine whether (a) suicidal ideation and attempt are related to onset of alcohol, nicotine and cannabis use and dependence; (b) early use of alcohol, nicotine and cannabis is associated with onset of suicidal ideation and attempt; and (c) whether these associations persist while controlling for covariates, such as family history of alcohol problems, major depression and other internalizing and externalizing disorders...
February 3, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28210778/threshold-dose-for-behavioral-discrimination-of-cigarette-nicotine-content-in-menthol-vs-non-menthol-smokers
#6
Kenneth A Perkins, Nicole Kunkle, Joshua L Karelitz
RATIONALE: The lowest threshold content (or "dose") of nicotine discriminated in cigarettes may differ due to menthol preference. OBJECTIVES: Menthol and non-menthol Spectrum research cigarettes differing in nicotine content were used to determine discrimination thresholds. METHODS: Dependent smokers preferring menthol (n = 40) or non-menthol (n = 21) brands were tested on ability to discriminate cigarettes (matched for their menthol preference) with nicotine contents of 16-17, 11-12, 5, 2, and 1 mg/g, one per session, from an "ultra-low" cigarette with 0...
February 16, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28209422/-the-role-of-spirometry-in-encouraging-smoking-cessation-in-general-practice-a-pilot-study-using-lung-age
#7
A Lorenzo, F Noël, M Lorenzo, J Van Den Broucke
INTRODUCTION: Our aim was to investigate whether spirometry, performed in general practitioners' offices would change non-motivated smokers' attitudes toward smoking cessation. METHOD: We performed an interventional, prospective, before-after single-center study, approved by a research ethics committee. We included 74 smokers older than 18years old, who reported no intention to quit smoking, whatever they were visiting general practitioners for. We performed spirometry and gave them their results, FEV1/FVC and lung age together with a comment on it...
February 13, 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/28198988/e-smoking-among-students-of-medicine-frequency-pattern-and-motivations
#8
Grzegorz Brożek, Mateusz Jankowski, Jan Zejda, Agnieszka Jarosińska, Agnieszka Idzik, Piotr Bańka
INTRODUCTION: E-smoking has become a public health problem. The objectives of this study were to assess the prevalence of e-cigarette and tobacco cigarette use; to compare the patterns of smoking; to assess the attitudes and motivations for e-cigarette use. MATERIAL AND METHODS: All 1,700 students from Faculty of Medicine (Medical University of Silesia) were invited to questionnaire based cross-sectional study about the frequency and attitudes towards the use of traditional and electronic cigarettes...
2017: Adv Respir Med
https://www.readbyqxmd.com/read/28197544/plasticity-in-brainstem-mechanisms-of-pain-modulation-by-nicotinic-acetylcholine-receptors-in-the-rat
#9
Francis J Jareczek, Stephanie R White, Donna L Hammond
Individuals with chronic pain may be driven to smoke more because the analgesic efficacy of nicotine diminishes. To determine whether persistent pain diminishes the actions of a nicotinic acetylcholine receptor (nAChR) agonist in pain modulatory pathways, we examined the effects of epibatidine in the rostral ventromedial medulla (RVM) of rats with and without inflammatory injury induced by intraplantar injection of complete Freund's adjuvant (CFA). In uninjured rats, epibatidine produced a dose-dependent antinociception that was completely blocked by dihydro-β-erythroidine (DHβE; α4β2 antagonist) and partially blocked by methyllycaconitine (MLA; α7 antagonist)...
January 2017: ENeuro
https://www.readbyqxmd.com/read/28197102/right-cervical-vagotomy-aggravates-viral-myocarditis-in-mice-via-the-cholinergic-anti-inflammatory-pathway
#10
Ge Li-Sha, Chen Xing-Xing, Wu Lian-Pin, Zhou De-Pu, Li Xiao-Wei, Lin Jia-Feng, Li Yue-Chun
The autonomic nervous system dysfunction with increased sympathetic activity and withdrawal of vagal activity may play an important role in the pathogenesis of viral myocarditis. The vagus nerve can modulate the immune response and control inflammation through a 'cholinergic anti-inflammatory pathway' dependent on the α7-nicotinic acetylcholine receptor (α7nAChR). Although the role of β-adrenergic stimulation on viral myocarditis has been investigated in our pervious studies, the direct effect of vagal tone in this setting has not been yet studied...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28195010/efficacy-of-a-universal-smoking-cessation-intervention-initiated-in-inpatient-psychiatry-and-continued-post-discharge-a-randomised-controlled-trial
#11
Alexandra P Metse, John Wiggers, Paula Wye, Luke Wolfenden, Megan Freund, Richard Clancy, Emily Stockings, Margarett Terry, John Allan, Kim Colyvas, Judith J Prochaska, Jenny A Bowman
OBJECTIVE: Interventions are required to redress the disproportionate tobacco-related health burden experienced by persons with a mental illness. This study aimed to assess the efficacy of a universal smoking cessation intervention initiated within an acute psychiatric inpatient setting and continued post-discharge in reducing smoking prevalence and increasing quitting behaviours. METHOD: A randomised controlled trial was undertaken across four psychiatric inpatient facilities in Australia...
February 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/28191914/relative-contribution-of-genetic-individual-and-self-efficacy-factors-to-smoking-cessation-in-a-chinese-rural-population
#12
Qiang Wang, Suyun Li, Huijie Li, Xiaorong Yang, Fan Jiang, Nan Zhang, Mingkui Han, Chongqi Jia
BACKGROUND AND OBJECTIVES: Nicotine dependence is influenced by genetic, individual, and psychological factors. We aimed to examine whether nicotinic acetylcholine receptor genes (CHRN) were associated with smoking cessation (SC) using genetic risk score and compare the relative contribution of genetic, individual and self-efficacy factors to SC. METHODS: Eight hundred and nineteen male smokers (mean age: 59.62) were recruited from 17 villages of three counties in Shandong province, China...
February 13, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28190719/feasibility-and-pilot-efficacy-of-a-brief-smoking-cessation-intervention-delivered-by-vascular-surgeons-in-the-vascular-physician-offer-and-report-vapor-trial
#13
Philip P Goodney, Emily L Spangler, Karina Newhall, Benjamin S Brooke, Andres Schanzer, Tze-Woei Tan, Adam W Beck, John H Hallett, Todd A MacKenzie, Maria O Edelen, Andrew W Hoel, Nancy A Rigotti, Alik Farber
BACKGROUND: This study determined the feasibility and potential efficacy of an evidence-based standardized smoking cessation intervention delivered by vascular surgeons to smokers with peripheral arterial disease. METHODS: We performed a cluster-randomized trial of current adult smokers referred to eight vascular surgery practices from September 1, 2014, to July 31, 2015. A three-component smoking cessation intervention (physician advice, nicotine replacement therapy, and telephone-based quitline referral) was compared with usual care...
February 9, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28187830/lack-of-cross-resistance-between-neonicotinoids-and-sulfoxaflor-in-field-strains-of-q-biotype-of-whitefly-bemisia-tabaci-from-eastern-china
#14
Wenlong Wang, Shaoli Wang, Guangjie Han, Yuzhou Du, Jianjun Wang
Control of Bemisia tabaci has depended primarily and heavily on insecticides, especially neonicotinoids. The novel sulfoximine insecticide sulfoxaflor exhibits high potency against a broad range of sap-feeding insect species, including those resistant to neonicotinoids. The resistance levels of Q-biotype B. tabaci field strains collected from 8 locations in eastern China to neonicotinoids and sulfoxaflor were investigated, and single nucleotide polymorphisms (SNPs) of nicotinic acetylcholine receptor β1 subunit gene (Btβ1) were detected...
March 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/28185965/cav1-2-but-not-cav1-3-l-type-calcium-channel-subtype-mediates-nicotine-induced-conditioned-place-preference-in-miceo
#15
Yudan Liu, Meghan Harding, Jules Dore, Xihua Chen
Nicotine use is one of the most common forms of drug addiction. Although L-type calcium channels (LTCCs) are involved in nicotine addiction, the contribution of the two primary LTCC subtypes (Cav1.2 and 1.3) is unknown. This study aims to determine the contribution of these two LTCC subtypes to nicotine-induced conditioned place preference (CPP) responses by using transgenic mouse models that do not express Cav1.3 (Cav1.3(-/-)) or contain a mutation in the dihydropyridine (DHP) site of the Cav1.2 (Cav1.2DHP(-/-))...
February 6, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28185963/increased-network-centrality-as-markers-of-relapse-risk-in-nicotine-dependent-individuals-treated-with-varenicline
#16
Zhujing Shen, Peiyu Huang, Chao Wang, Wei Qian, Yihong Yang, Minming Zhang
Identifying smokers at high risk of relapse could improve the effectiveness of cessation therapies. Although altered regional brain function in smokers has been reported, whether the whole-brain functional organization differs smokers with relapse vulnerability from others remains unclear. Thus, the goal of this study is to investigate the baseline functional connectivity differences between relapsers and quitters. Using resting-state fMRI, we acquired images from 57 smokers prior to quitting attempts. After 12-week treatment with varenicline, smokers were divided into relapsers (n=36) and quitters (n=21) (quitter: continuously abstinent for weeks 9-12)...
February 6, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28185257/system-change-interventions-for-smoking-cessation
#17
REVIEW
Dennis Thomas, Michael J Abramson, Billie Bonevski, Johnson George
BACKGROUND: System change interventions for smoking cessation are policies and practices designed by organizations to integrate the identification of smokers and the subsequent offering of evidence-based nicotine dependence treatments into usual care. Such strategies have the potential to improve the provision of smoking cessation support in healthcare settings, and cessation outcomes among those who use them. OBJECTIVES: To assess the effectiveness of system change interventions within healthcare settings, for increasing smoking cessation or the provision of smoking cessation care, or both...
February 10, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28184877/understanding-nicotine-dependence-and-addiction-among-young-adults-who-smoke-cigarillos-a-qualitative-study
#18
Elizabeth Antognoli, David Cavallo, Erika Trapl, Mary Step, Sarah Koopman Gonzalez, Rose Perez, Susan Flocke
No abstract text is available yet for this article.
February 10, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28183022/temporal-sequencing-of-nicotine-dependence-and-major-depressive-disorder-a-u-s-national-study
#19
José M Martínez-Ortega, Silvia Franco, Jorge M Rodríguez-Fernández, Luis Gutiérrez-Rojas, Shuai Wang, Manuel Gurpegui
Major Depressive Disorder (MDD) and Nicotine dependence (ND) often co-occur. However, little attention has been given to the temporal order between the two disorders. We compared the sociodemographic and clinical characteristics of individuals whose onset of ND preceded (ND-prior) or followed the onset of MDD (MDD-prior). Binary logistic regression models were computed to compare ND-prior (n=546) and MDD-prior (n=801) individuals from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC, n=43,093)...
February 1, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28182735/chrna2-martinotti-cells-synchronize-layer-5-type-a-pyramidal-cells-via-rebound-excitation
#20
Markus M Hilscher, Richardson N Leão, Steven J Edwards, Katarina E Leão, Klas Kullander
Martinotti cells are the most prominent distal dendrite-targeting interneurons in the cortex, but their role in controlling pyramidal cell (PC) activity is largely unknown. Here, we show that the nicotinic acetylcholine receptor α2 subunit (Chrna2) specifically marks layer 5 (L5) Martinotti cells projecting to layer 1. Furthermore, we confirm that Chrna2-expressing Martinotti cells selectively target L5 thick-tufted type A PCs but not thin-tufted type B PCs. Using optogenetic activation and inhibition, we demonstrate how Chrna2-Martinotti cells robustly reset and synchronize type A PCs via slow rhythmic burst activity and rebound excitation...
February 2017: PLoS Biology
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