keyword
MENU ▼
Read by QxMD icon Read
search

Comparative effectiveness research

keyword
https://www.readbyqxmd.com/read/29236149/transcatheter-aortic-valve-replacement-with-balloon-expandable-valve-analysis-of-initial-experience-in-china
#1
Y Shen, H Zhang, L Zhang, H Li, H Mao, Y Pei, Z Jing, Q Lu
BACKGROUND: Transcatheter aortic valve replacement (TAVR) is widely applied for the treatment of severe aortic stenosis (AS) in developed countries; however, in China, it is still in the early stage of utilization. On the basis of previous studies, this work explored the feasibility of TAVR in patients with severe AS in China and analyzed the cause of death in four cases. METHODS: This retrospective study included 20 patients who had severe AS and underwent TAVR with a balloon-expandable system (Edwards SAPIEN XT) in our hospital from January 2011 to June 2016...
December 13, 2017: Herz
https://www.readbyqxmd.com/read/29235242/the-effect-of-an-educational-intervention-based-on-clinical-simulation-on-the-diagnosis-of-rheumatoid-arthritis-and-osteoarthritis
#2
Daniel G Fernández-Ávila, Álvaro J Ruiz, Fabián Gil, Sergio A Mora, Carlos Tobar, Juan M Gutiérrez, Diego Rosselli
OBJECTIVE: The aim of the present study was to evaluate the effectiveness of an educational tool for general physicians, based on rheumatological clinical simulation, for the diagnosis of rheumatoid arthritis and osteoarthritis. METHODS: A randomized clinical study was carried out, in which the physician research subjects were assigned to one of two groups: the experimental group (educational intervention for rheumatoid arthritis with clinical simulation) or the control group (educational intervention for the basic aspects of the diagnosis and treatment of osteoporosis)...
December 13, 2017: Musculoskeletal Care
https://www.readbyqxmd.com/read/29235193/chronic-musculoskeletal-pain-in-european-older-adults-cross-national-and-gender-differences
#3
M Cimas, A Ayala, B Sanz, M S Agulló-Tomás, A Escobar, M J Forjaz
BACKGROUND: In an ageing Europe, chronic pain is a major public health problem, but robust epidemiological data are scarce. This study aimed to analyse the prevalence of and factors associated with chronic musculoskeletal pain by gender in older adults of 14 European countries. METHODS: A cross-sectional study was performed from wave 5 of the Survey of Health, Ageing and Retirement in Europe (SHARE). The study included people ≥50 years residing in Austria, Belgium, Czech Republic, Denmark, Estonia, France, Germany, Italy, Luxembourg, the Netherlands, Slovenia, Spain, Sweden and Switzerland...
December 12, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29235150/efficacy-and-tolerability-of-antidepressants-in-parkinson-s-disease-a-systematic-review-and-network-meta-analysis
#4
Kelly A Mills, M Claire Greene, Rebecca Dezube, Carrie Goodson, Taruja Karmarkar, Gregory M Pontone
OBJECTIVE: To systematically review and analyze the efficacy and tolerability of different antidepressant pharmacologic treatments for depressive symptoms in Parkinson's disease (PD) METHODS: We searched PubMed, EMBASE, Cochrane database (CENTRAL), clinicaltrials.gov, and bibliographies for randomized controlled trials investigating the efficacy of antidepressant medications versus a non-treatment, placebo, or active treatment groups for depressive symptoms in PD. Twenty of 3191 retrieved studies (1893 patients) were included, but not all could be meta-analyzed...
December 13, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29235042/rapid-quadrupole-time-of-flight-mass-spectrometry-method-quantifies-oxygen-rich-lignin-compound-in-complex-mixtures
#5
Kelsey S Boes, Michael S Roberts, Nelson R Vinueza
Complex mixture analysis is a costly and time-consuming task facing researchers with foci as varied as food science and fuel analysis. When faced with the task of quantifying oxygen-rich bio-oil molecules in a complex diesel mixture, we asked whether complex mixtures could be qualitatively and quantitatively analyzed on a single mass spectrometer with mid-range resolving power without the use of lengthy separations. To answer this question, we developed and evaluated a quantitation method that eliminated chromatography steps and expanded the use of quadrupole-time-of-flight mass spectrometry from primarily qualitative to quantitative as well...
December 12, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29234903/biodistribution-and-radiation-dosimetry-of-64cu-copper-dichloride-first-in-human-study-in-healthy-volunteers
#6
M A Avila-Rodriguez, C Rios, J Carrasco-Hernandez, J C Manrique-Arias, R Martinez-Hernandez, F O García-Pérez, A R Jalilian, E Martinez-Rodriguez, M E Romero-Piña, A Diaz-Ruiz
BACKGROUND: In recent years, Copper-64 (T1/2 = 12.7 h) in the chemical form of copper dichloride ([64Cu]CuCl2) has been identified as a potential agent for PET imaging and radionuclide therapy targeting the human copper transporter 1, which is overexpressed in a variety of cancer cells. Limited human biodistribution and radiation dosimetry data is available for this tracer. The aim of this research was to determine the biodistribution and estimate the radiation dosimetry of [64Cu]CuCl2, using whole-body (WB) PET scans in healthy volunteers...
December 12, 2017: EJNMMI Research
https://www.readbyqxmd.com/read/29234895/intestinal-stem-cells-to-advance-drug-development-precision-and-regenerative-medicine-a-paradigm-shift-in-translational-research
#7
Jonathan P Mochel, Albert E Jergens, Dawn Kingsbury, Hyun Jung Kim, Martín G Martín, Karin Allenspach
Recent advances in our understanding of the intestinal stem cell niche and the role of key signaling pathways on cell growth and maintenance have allowed the development of fully differentiated epithelial cells in 3D organoids. Stem cell-derived organoids carry significant levels of proteins that are natively expressed in the gut and have important roles in drug transport and metabolism. They are, therefore, particularly relevant to study the gastrointestinal (GI) absorption of oral medications. In addition, organoids have the potential to serve as a robust preclinical model for demonstrating the effectiveness of new drugs more rapidly, with more certainty, and at lower costs compared with live animal studies...
December 12, 2017: AAPS Journal
https://www.readbyqxmd.com/read/29234892/how-accurate-is-the-description-of-ligand-protein-interactions-by-a-hybrid-qm-mm-approach
#8
Jakub Kollar, Vladimir Frecer
During the last decades, the application of hybrid quantum mechanical/molecular mechanical (QM/MM) methods has been extended to the field of drug design. In principle, the approximate QM/MM approach offers a more complete description of drug-receptor non-covalent interactions. This is especially true when charge or proton transfer, chelation of metal ions or strong polarization of ligand and protein or surface chemical groups are involved. The aim of this work was to assess the accuracy of calculated non-covalent ligand-protein interaction energies ([Formula: see text]) obtained by the hybrid QM/MM approach employed in QSite/Jaguar of Schrödinger's Small-Molecule Drug Discovery Suite on a set of small-molecule model systems when compared to rigorous QM calculations...
December 12, 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29234826/mental-health-impact-of-social-capital-interventions-a-systematic-review
#9
Elaine C Flores, Daniela C Fuhr, Angela M Bayer, Andres G Lescano, Nicki Thorogood, Victoria Simms
PURPOSE: Mental disorders are a major contributor to the global burden of disease and disability, and can be extremely costly at both individual and community level. Social capital, (SC) defined as an individual's social relationships and participation in community networks, may lower the risk of mental disorders while increasing resilience capacity, adaptation and recovery. SC interventions may be a cost-effective way of preventing and ameliorating these conditions. However, the impact of these SC interventions on mental health still needs research...
December 12, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/29234561/comparison-of-functional-activities-on-structural-changes-of-the-inferior-patellar-pole
#10
Kelli McKinney, Harvey Wallmann, Patrick Stalcup, Katie DiTommaso
Background: It is well known that eccentric and concentric exercise produce varied amounts of stress on the connective tissues. Diagnostic ultrasound has been used to measure these structural changes by observing fascicle length, angle, and thickness; however, there is a lack of evidence comparing the structural changes as it relates to eccentric, concentric, and stretching protocols. Purpose: The purpose of this study was to compare the acute effects of static stretching, eccentric, concentric, and a combination of eccentric/concentric exercises on structural changes of the muscle tendon unit at the inferior patellar pole utilizing the diagnostic ultrasound...
December 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/29234466/the-effect-of-variation-in-interpretation-of-the-la-trobe-radiographic-foot-atlas-on-the-prevalence-of-foot-osteoarthritis-in-older-women-the-chingford-general-population-cohort
#11
Peter McQueen, Lucy Gates, Michelle Marshall, Michael Doherty, Nigel Arden, Catherine Bowen
Background: The prevalence of foot osteoarthritis (OA) is much less understood than hip, knee and hand OA. The foot is anatomically complex and different researchers have investigated different joints with lack of methodological standardisation across studies. The La Trobe Foot Atlas (LFA) is the first to address these issues in providing quantitative assessment of radiographic foot OA, but has not been tested externally. The aim of this study was to evaluate three different interpretive approaches to using the LFA for grading OA when scoring is difficult due to indistinct views of interosseous space and joint contour...
2017: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/29234419/effect-of-sheng-jiang-powder-on-obesity-induced-multiple-organ-injuries-in-rats
#12
Juan Li, Yu-Mei Zhang, Jun-Yi Li, Lv Zhu, Hong-Xin Kang, Hong-Yu Ren, Huan Chen, Ling Yuan, Yi-Fan Miao, Mei-Hua Wan, Wen-Fu Tang
Background and Aims: Obesity has become the main public health issue nowadays with poor control and has been associated with increased risk of multiorgan disease, but the specific mechanism and effective medication are still to be addressed. Sheng-jiang powder (SJP) showed great potential in preventing obesity in Chinese researches but has no trace in English reports. This study was designed to investigate the effect of SJP on obesity and obesity-mediated multiorgan injuries. Methods: Rats were randomized into normal group (NG), obese group (OG), and SJP treatment group (SG)...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29234395/the-effect-of-dongeui-qigong-for-prehypertension-and-mild-essential-hypertension
#13
Ji-Eun Park, Jung-Eun Kim, Soyoung Jung, Aeran Kim, Hyoju Park, Sanghoon Hong
Although several previous studies have reported the effect of qigong on lowering blood pressure, rigorous trials are lacking. Studies evaluating the effect of qigong on prehypertension are also scarce. This study aimed to assess the effect of qigong on prehypertension and mild hypertension. Participants with prehypertension or mild hypertension were randomized to the Dongeui qigong group or a nontreated control group. In the qigong group, Dongeui qigong was administered 5 times/week for 12 weeks. The control group did not receive any intervention for blood pressure control...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29234133/multi-channel-microfluidic-chip-coupling-with-mass-spectrometry-for-simultaneous-electro-sprays-and-extraction
#14
Cilong Yu, Fei Tang, Xiang Qian, Yan Chen, Quan Yu, Kai Ni, Xiaohao Wang
Considering the advantages and research status of microfluidic chip coupling with mass spectrometry (MS), a microfluidic chip-based multi-channel ionization (MCMCI) for the extraction of untreated compounds in complex matrices without sample pretreatments was developed. Quantitative analysis of human urine spiked with various rhodamine B concentrations was also performed, and good linearity was obtained. Comparing to the macro ionization device, MCMCI significantly improved the integration of ionization source, simplified the operation of such a device, and greatly increased the signal intensity with much lower gas pressure...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29233498/proton-pump-inhibitors-and-cardiovascular-events-a-systematic-review
#15
REVIEW
Timothy P Shiraev, Andrew Bullen
BACKGROUND: Proton pump inhibitors (PPIs) are a commonly prescribed medication that recent data has linked to an increased risk of cardiovascular morbidity and all cause morbidity. The current study sought to perform a systematic review to investigate the link between PPIs and morbidity and mortality METHODS: A systematic review was carried out as per the PRISMA guidelines, with information databases including Pubmed, Medline, and the Cochrane Review Database. English-language studies of all types published from January 1990 to October 2016 were considered...
November 20, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29233388/peer-teaching-as-an-educational-tool-in-pharmacy-schools-fruitful-or-futile
#16
REVIEW
Mona Hassan Aburahma, Heba Moustafa Mohamed
BACKGROUND: In the past decade, various health care programs have implemented diverse types of peer-assisted learning (PAL) programs, in particularly peer teaching (PT), due to their reported benefits for students (both those undertaking teaching and those being taught), teachers, and educational institutes. Unfortunately, peer teaching is still under-recognized in pharmacy programs worldwide when compared to other health care programs. The aim of this review is to provide an overview of the published literature centered on formal PT programs that are implemented in pharmacy schools...
November 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29233291/impact-of-a-fictional-reading-intervention-on-empathy-development-in-student-pharmacists
#17
Karin L Collins, Ann Zweber, Adriane N Irwin
OBJECTIVE: Determine the impact of a short longitudinal literary fiction intervention on empathy development in student pharmacists as measured by the Jefferson Scale of Empathy - Health Profession Students (JSE-HPS) version. METHODS: Twenty-one student pharmacists were randomized to an intervention consisting of reading short excerpts of literary fiction over eight weeks (n=11) or a control group not participating in the intervention (n=10). Both groups completed the JSE-HPS at baseline and completion of the literary intervention...
May 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29233168/a-protocol-for-a-systematic-review-of-economic-evaluation-studies-conducted-on-neonatal-systemic-infections-in-south-asia
#18
Shruti Murthy, Denny John, Isadora Perpetual Godinho, Myron Anthony Godinho, Vasudeva Guddattu, N Sreekumaran Nair
BACKGROUND: Neonatal systemic infections and their consequent impairments give rise to long-lasting health, economic and social effects on the neonate, the family and the nation. Considering the dearth of consolidated economic evidence in this important area, this systematic review aims to critically appraise and consolidate the evidence on economic evaluations of management of neonatal systemic infections in South Asia. METHODS: Full and partial economic evaluations, published in English, associated with the management of neonatal systemic infections in South Asia will be included...
December 12, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29233133/user-testing-of-an-adaptation-of-fishbone-diagrams-to-depict-results-of-systematic-reviews
#19
Gerald Gartlehner, Marie-Therese Schultes, Viktoria Titscher, Laura C Morgan, Georgiy V Bobashev, Peyton Williams, Suzanne L West
BACKGROUND: Summary of findings tables in systematic reviews are highly informative but require epidemiological training to be interpreted correctly. The usage of fishbone diagrams as graphical displays could offer researchers an effective approach to simplify content for readers with limited epidemiological training. In this paper we demonstrate how fishbone diagrams can be applied to systematic reviews and present the results of an initial user testing. METHODS: Findings from two systematic reviews were graphically depicted in the form of the fishbone diagram...
December 12, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29233123/impact-of-place-of-residence-on-place-of-death-in-wales-an-observational-study
#20
S R Ziwary, D Samad, C D Johnson, R T Edwards
BACKGROUND: Previous research in England showed that deprivation level of a person's place of residence affects the place of death and quality of care received at the end of life. People dying in their preferred place of death has also been shown to act as an indication for high quality of end of life care services and social equality. This study expands on current research to explore the effects of deprivation and place of residence on health related choices and place of death in Wales...
December 12, 2017: BMC Palliative Care
keyword
keyword
19237
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"