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https://www.readbyqxmd.com/read/29241222/flavopiridol-enhances-abt-199-sensitivity-in-unfavourable-risk-multiple-myeloma-cells-in-vitro-and-in-vivo
#1
Liang Zhou, Yu Zhang, Deepak Sampath, Joel Leverson, Yun Dai, Maciej Kmieciak, Matthew Nguyen, Robert Z Orlowski, Steven Grant
BACKGROUND: The BCL-2-specific BH3-mimetic ABT-199 (venetoclax) has been reported to be principally active against favourable-risk multiple myeloma (MM) cells, prompting efforts to extend its activity to include more resistant, higher-risk MM subsets. METHODS: Effects of the CDK9 inhibitor flavopiridol (FP; alvocidib) on responses to ABT-199 were examined in MM cells. Cell death and protein expression were evaluated by western blot and immunofluorescence. Xenograft models were used to study combination effects in vivo...
December 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29241144/the-diverse-reasons-for-using-novel-psychoactive-substances-a-qualitative-study-of-the-users-own-perspectives
#2
Christophe Soussan, Martin Andersson, Anette Kjellgren
BACKGROUND: The increasing number of legally ambiguous and precarious Novel Psychoactive Substances (NPS) constitutes a challenge for policy makers and public health. Scientific and more in-depth knowledge about the motivations for using NPS is scarce and often consist of predetermined, non-systematic, or poorly described reasons deduced from top-down approaches. Therefore, the aim of the present study was to explore and characterize the users' self-reported reasons for NPS use inductively and more comprehensively...
December 11, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29241143/perceptions-about-supervised-injection-facilities-among-people-who-inject-drugs-in-philadelphia
#3
Robert E Harris, Jessica Richardson, Rosemary Frasso, Evan D Anderson
BACKGROUND: People who inject drugs (PWID) are at high risk for infectious diseases, skin and soft tissue infections, and overdose. However, these harms are all avoidable when sterile injection equipment, hygienic places to inject, and medical care are accessible. Unfortunately, many PWID in the U.S lack these resources. The most vulnerable are forced to inject in public spaces, where individual risks are high and communal harms are sometimes many. Supervised Injection Facilities (SIFs) are an established intervention for reducing these harms...
December 10, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29241098/under-ascertainment-under-reporting-and-timeliness-of-iranian-communicable-disease-surveillance-system-for-zoonotic-diseases
#4
P A Kazerooni, M Fararouei, M Nejat, M Akbarpoor, Z Sedaghat
OBJECTIVES: The important steps in controlling infectious diseases are fast detection, proper treatment and on-time reporting of cases to the appropriate authorities. This study was conducted to evaluate the quality of Iranian communicable diseases surveillance system (CDSS) for zoonotic diseases in rural areas of Fars province (Iran's third largest province). STUDY DESIGN: The three most important evaluation indices of CDSS, namely under-ascertainment, under-reporting and timeliness, for the three most common zoonotic diseases were measured using independent data source obtained from door-to-door interviews and patients' medical records...
December 11, 2017: Public Health
https://www.readbyqxmd.com/read/29241063/red-warning-for-air-pollution-in-china-exploring-residents-perceptions-of-the-first-two-red-warnings-in-beijing
#5
Hanping Zhao, Fangping Wang, Chence Niu, Han Wang, Xiaoxue Zhang
Air pollution early warnings have been issued in China to mitigate the effects of high pollution days. Public perceptions and views about early warning signals can affect individual behaviors and play a major role in the public's response to air pollution risks. This study examined public attitudes and responses to the first two red warnings for air pollution in Beijing in 2015. An online survey was sent out, and 664 respondents (response rate = 90%) provided their perspectives on the red warnings. Descriptive statistics, sign tests and binary logit models were used to analyze the data...
December 11, 2017: Environmental Research
https://www.readbyqxmd.com/read/29240917/leisure-centre-entrance-charges-and-physical-activity-participation-in-england
#6
F Ward, E C Halliday, B Barr, J Higgerson, V Holt
Reducing or eliminating the cost to the public of using leisure facilities is one tool that local authorities have available to reduce inequalities in physical activity (PA). There is limited evidence about the effect of leisure entrance charges and their impact on participation. This study aimed to ascertain how facility pricing influenced the decisions people made about how to pay and what to pay for and how, in turn, these decisions impacted on participation for different groups. A total of 83 members of the public living in 4 local authorities in the North West of England were involved in focus groups or individual interviews...
December 11, 2017: Health Promotion International
https://www.readbyqxmd.com/read/29240827/diagnostic-accuracy-research-in-glaucoma-is-still-incompletely-reported-an-application-of-standards-for-reporting-of-diagnostic-accuracy-studies-stard-2015
#7
Manuele Michelessi, Ersilia Lucenteforte, Alba Miele, Francesco Oddone, Giada Crescioli, Valeria Fameli, Daniël A Korevaar, Gianni Virgili
BACKGROUND: Research has shown a modest adherence of diagnostic test accuracy (DTA) studies in glaucoma to the Standards for Reporting of Diagnostic Accuracy Studies (STARD). We have applied the updated 30-item STARD 2015 checklist to a set of studies included in a Cochrane DTA systematic review of imaging tools for diagnosing manifest glaucoma. METHODS: Three pairs of reviewers, including one senior reviewer who assessed all studies, independently checked the adherence of each study to STARD 2015...
2017: PloS One
https://www.readbyqxmd.com/read/29240727/health-and-development-at-age-19-24-months-of-19-children-who-were-born-with-microcephaly-and-laboratory-evidence-of-congenital-zika-virus-infection-during-the-2015-zika-virus-outbreak-brazil-2017
#8
Ashley Satterfield-Nash, Kim Kotzky, Jacob Allen, Jeanne Bertolli, Cynthia A Moore, Isabela Ornelas Pereira, André Pessoa, Flavio Melo, Ana Carolina Faria E Silva Santelli, Coleen A Boyle, Georgina Peacock
In November 2015, the Brazilian Ministry of Health (MOH) declared the Zika virus outbreak a public health emergency after an increase in microcephaly cases was reported in the northeast region of the country (1). During 2015-2016, 15 states in Brazil with laboratory-confirmed Zika virus transmission reported an increase in birth prevalence of microcephaly (2.8 cases per 10,000 live births), significantly exceeding prevalence in four states without confirmed transmission (0.6 per 10,000) (2). Although children with microcephaly and laboratory evidence of Zika virus infection have been described in early infancy (3), their subsequent health and development have not been well characterized, constraining planning for the care and support of these children and their families...
December 15, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29240725/notice-to-readers-change-in-mmwr-announcements
#9
(no author information available yet)
Effective January 12, 2018, Announcements will be limited to public health events (e.g., World AIDS Day or Great American Smokeout) that are topically related to Full Reports. Both the Announcement and Full Report will appear on the cover of the issue. Information about other national health observances is available at https://healthfinder.gov/NHO/default.aspx.
December 15, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29240707/molecular-mechanisms-of-zinc-oxide-nanoparticle-induced-genotoxicity-short-running-title-genotoxicity-of-zno-nps
#10
REVIEW
Agmal Scherzad, Till Meyer, Norbert Kleinsasser, Stephan Hackenberg
BACKGROUND: Zinc oxide nanoparticles (ZnO NPs) are among the most frequently applied nanomaterials in consumer products. Evidence exists regarding the cytotoxic effects of ZnO NPs in mammalian cells; however, knowledge about the potential genotoxicity of ZnO NPs is rare, and results presented in the current literature are inconsistent. OBJECTIVES: The aim of this review is to summarize the existing data regarding the DNA damage that ZnO NPs induce, and focus on the possible molecular mechanisms underlying genotoxic events...
December 14, 2017: Materials
https://www.readbyqxmd.com/read/29240614/a-measure-of-the-potential-impact-of-hospital-community-health-activities-on-population-health-and-equity
#11
James W Begun, Linda M Kahn, Brooke A Cunningham, Jan K Malcolm, Sandra Potthoff
CONTEXT: Many hospitals in the United States are exploring greater investment in community health activities that address upstream causes of poor health. OBJECTIVE: Develop and apply a measure to categorize and estimate the potential impact of hospitals' community health activities on population health and equity. DESIGN, SETTING, AND PARTICIPANTS: We propose a scale of potential impact on population health and equity, based on the cliff analogy developed by Jones and colleagues...
December 13, 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/29240613/assessing-the-knowledge-skills-and-abilities-of-public-health-professionals-in-big-city-governmental-health-departments
#12
Meghan D McGinty, Brian C Castrucci, Debra M Rios
OBJECTIVE: To identify essential knowledge, skills, and abilities (KSAs) for and characterize gaps in KSAs of professionals working in large, urban health departments. DESIGN: A survey was disseminated to potentially eligible supervisors within 26 of 28 health departments in the largest, most urban jurisdictions in the country. A supervisor was eligible to participate if he or she supervised at least 1 staff member whose highest level of education was a master's degree...
December 13, 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/29240537/infertility-and-self-rated-health-among-malawian-women
#13
Nisha Rao, Allahna Esber, Abigail Turner, Gladson Mopiwa, Joana Banda, Alison Norris
BACKGROUND: Infertility is prevalent and stigmatized in sub-Saharan Africa. Self-rated health, a subjective indicator that has been consistently related to objectively measured health, may be useful in evaluating the relationship between women's infertility and health. METHODS: Data were from surveys conducted from July 2014 to January 2015 with women aged 15 to 39 years (n = 915) as part of the initial assessment in a cohort study in Lilongwe district, Malawi...
December 14, 2017: Women & Health
https://www.readbyqxmd.com/read/29240535/factors-associated-with-waterpipe-tobacco-smoking-among-lebanese-women
#14
Karim N Daou, Ibrahim R Bou-Orm, Salim M Adib
INTRODUCTION: Waterpipe tobacco smoking (WTS) has become a serious public health threat in the Middle-East and beyond. OBJECTIVES: To estimate the prevalence rates of cigarette and WTS among Lebanese women and describe characteristics associated with each behavior. METHODS: Secondary analysis of women's health data obtained in a national survey in 2010. RESULTS: Of 2255 selected women, 78% reported no or past long-term WTS...
December 14, 2017: Women & Health
https://www.readbyqxmd.com/read/29240274/complement-factor-h-gene-polymorphism-rs6677604-and-the-risk-severity-and-progression-of-iga-nephropathy-a-systematic-review-and-meta-analysis
#15
See Cheng Yeo, Xinyang Liu, Adrian Liew
BACKGROUND & AIM: Complement activation plays a key role in the pathogenesis of IgA nephropathy (IgAN). Several studies have reported an association between complement factor H gene rs6677604 polymorphism and susceptibility to IgAN; however, attempts at validating this relationship had yielded inconsistent results. We performed a systematic review and meta-analysis to clarify the association between rs6677604 and IgAN susceptibility, disease severity and chronic progression. METHODS: A comprehensive database search was performed to identify eligible studies...
December 14, 2017: Nephrology
https://www.readbyqxmd.com/read/29240080/reinterpretation-of-sequence-variants-one-diagnostic-laboratory-s-experience-and-the-need-for-standard-guidelines
#16
Caitlin Chisholm, Hussein Daoud, Mahdi Ghani, Gabrielle Mettler, Jean McGowan-Jordan, Liz Sinclair-Bourque, Amanda Smith, Olga Jarinova
PurposeThe advent of next-generation sequencing resulted in substantial increases in the number of variants detected, interpreted, and reported by molecular genetics diagnostic laboratories. Recent publications have provided standards for the interpretation of sequence variants, but there are currently no standards regarding reinterpretation of these variants. Recognizing that significant changes in variant classification may occur over time, many genetics diagnostic laboratories have independently developed practices for variant reinterpretation...
December 14, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29240077/clinically-impactful-differences-in-variant-interpretation-between-clinicians-and-testing-laboratories-a-single-center-experience
#17
Austin Bland, Elizabeth A Harrington, Kyla Dunn, Mitchel Pariani, Julia C K Platt, Megan E Grove, Colleen Caleshu
PurposeTo describe the frequency and nature of differences in variant classifications between clinicians and genetic testing laboratories.MethodsRetrospective review of variants identified through genetic testing ordered in routine clinical care by clinicians in the Stanford Center for Inherited Cardiovascular Disease. We compared classifications made by clinicians, the testing laboratory, and other laboratories in ClinVar.ResultsOf 688 laboratory classifications, 124 (18%) differed from the clinicians' classifications...
December 14, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29240041/reduction-of-excavation-face-collapse-risk-in-tunnelling
#18
Filippo Ariani, Alberto Baldasseroni, Alessandro Muller, Marco Biffino, Alessandro Matteucci
Two large road tunnels, recently developed near Florence, showed instabilities of the excavation face which subsequently caused sixteen collapses. Due to the risk for workers' safety, the public authority for occupational health and safety (ASL) has monitored the failure rate and other background variables in order to assess the possible correlations between risk reductions, its own actions, and those of the various safety actors involved. OBJECTIVES: To evaluate if the interventions carried out by the design team were able to reduce the risks of collapse and which of the ASL actions and/or which other factors were more effective in changing the attitudes of the parties involved, leading to a more expensive but safer project variant...
December 14, 2017: La Medicina del Lavoro
https://www.readbyqxmd.com/read/29239959/bias-in-before-after-studies-narrative-overview-for-anesthesiologists
#19
Anthony M H Ho, Rachel Phelan, Glenio B Mizubuti, John A C Murdoch, Sarah Wickett, Adrienne K Ho, Vidur Shyam, Ian Gilron
Before-after study designs are effective research tools and in some cases, have changed practice. These designs, however, are inherently susceptible to bias (ie, systematic errors) that are sometimes subtle but can invalidate their conclusions. This overview provides examples of before-after studies relevant to anesthesiologists to illustrate potential sources of bias, including selection/assignment, history, regression to the mean, test-retest, maturation, observer, retrospective, Hawthorne, instrumentation, attrition, and reporting/publication bias...
December 11, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29239903/proposed-performance-based-metrics-for-the-future-funding-of-graduate-medical-education-starting-the-conversation
#20
Kelly J Caverzagie, Susan W Lane, Niraj Sharma, John Donnelly, Jeffrey R Jaeger, Heather Laird-Fick, John P Moriarty, Darilyn V Moyer, Sara L Wallach, Richard M Wardrop, Alwin F Steinmann
Graduate medical education (GME) in the United States is financed by contributions from both federal and state entities that total over $15 billion annually. Within institutions, these funds are distributed with limited transparency to achieve ill-defined outcomes. To address this, the Institute of Medicine convened a committee on the governance and financing of GME to recommend finance reform that would promote a physician training system that meets society's current and future needs. The resulting report provided several recommendations regarding the oversight and mechanisms of GME funding, including implementation of performance-based GME payments, but did not provide specific details about the content and development of metrics for these payments...
December 12, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
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