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https://www.readbyqxmd.com/read/28227957/bidirectional-peripheral-nerve-interface-and-applications
#1
Nitish V Thakor, Qihong Wang, Elliot Greenwald, Nitish V Thakor, Qihong Wang, Elliot Greenwald, Elliot Greenwald, Nitish V Thakor, Qihong Wang
Peripheral nerves, due to their small size and complex innervation to organs and complex physiology, pose particularly significant challenges towards interfacing electrodes and electronics to enable neuromodulation. Here, we present a review of the technology for building such interface, including recording and stimulating electrodes and low power electronics, as well as powering. Of particular advantage to building a miniature implanted device is a "bidirectional" system that both senses from the nerves or surrogate organs and stimulates the nerves to affect the organ function...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227921/directionally-sensitive-peripheral-nerve-recording-bipolar-nerve-cuff-design
#2
Parisa Sabetian, Milos R Popovic, Paul B Yoo, Parisa Sabetian, Milos R Popovic, Paul B Yoo
Although bipolar nerve cuff electrodes (NCEs) are used in clinical neurostimulation therapies (e.g., epilepsy, obstructive sleep apnea), the use of this electrode as part of a closed-up controlled system is very limited. The literature points to high noise content (i.e., poor signal-to-noise ratio, SNR) as the primary reason for not using bipolar NCEs to record neural activity. In fact, over the past several decades, the pseudo-tripolar NCEs, the symmetric configuration of this electrode array (i.e., electrically-shorted side contacts) makes it very difficult to obtain directional information from the recorded neural activity (efferent vs...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227902/impairment-of-muscle-force-transmission-in-spastic-paretic-muscles-of-stroke-survivors
#3
Xiaogang Hu, Babak Afsharipour, William Zev Rymer, Nina L Suresh, Xiaogang Hu, Babak Afsharipour, William Zev Rymer, Nina L Suresh, Xiaogang Hu, Babak Afsharipour, William Zev Rymer, Nina L Suresh
Hemispheric stroke survivors tend to have persistent motor impairments, with muscle weakness and muscle spasticity observed concurrently in the affected muscles. The objective of this preliminary study was to identify whether impairment of muscle force transmission could contribute to weakness in spastic-paretic muscles of chronic stroke survivors. To characterize the efficiency of the transmission of muscle forces to the tendon, we activated biceps brachii muscle electrically by stimulating the musculocutaneous nerve with maximum current...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227825/real-time-autonomous-bladder-event-classification-and-closed-loop-control-from-single-channel-pressure-data
#4
Robert Karam, Swarup Bhunia, Steve Majerus, Steven W Brose, Margot S Damaser, Dennis Bourbeau, Robert Karam, Swarup Bhunia, Steve Majerus, Steven W Brose, Margot S Damaser, Dennis Bourbeau, Steve Majerus, Margot S Damaser, Robert Karam, Steven W Brose, Dennis Bourbeau, Swarup Bhunia
Urinary incontinence, or the loss of bladder control, is a debilitating condition affecting millions worldwide, which significantly reduces quality of life. Neuromodulation of lower urinary tract nerves can be used to treat sensations of urgency in many subjects, including those with Spinal Cord Injury (SCI). Event driven, or conditional stimulation has been investigated as a possible improvement to the state-of-the-art open-loop stimulation systems available today. However, this requires a robust, adaptive, and noise-tolerant method of classifying bladder function from real-time bladder pressure measurements...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227745/numerical-simulation-of-multipolar-configuration-and-prepulse-technique-to-obtain-spatially-reverse-recruitment-order
#5
Melissa Dali, Olivier Rossel, David Guiraud, Melissa Dali, Olivier Rossel, David Guiraud, Melissa Dali, Olivier Rossel, David Guiraud
In the context of functional electrical stimulation of peripheral nerves, the control of a specific motor or sensory functions may need selective stimulation to target the desired effect without others. In implanted stimulation, spatial selectivity is obtained using multipolar CUFF electrodes with specific spread of the current over each contact. Furthermore, electrical stimulation recruits large fibers before small ones, whereas the targeted function could be elicited by a specific fiber type i.e. fiber diameter...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227742/a-computational-model-of-orientation-dependent-activation-of-retinal-ganglion-cells
#6
Timothy Esler, Anthony N Burkitt, David B Grayden, Robert R Kerr, Bahman Tahayori, Hamish Meffin, Timothy Esler, Anthony N Burkitt, David B Grayden, Robert R Kerr, Bahman Tahayori, Hamish Meffin, Anthony N Burkitt, Timothy Esler, Hamish Meffin, David B Grayden, Robert R Kerr, Bahman Tahayori
Currently, a challenge in electrical stimulation for epiretinal prostheses is the avoidance of stimulation of axons of passage in the nerve fiber layer that originate from distant regions of the ganglion cell layer. A computational model of extracellular stimulation that captures the effect of neurite orientation in anisotropic tissue is developed using a modified version of the standard volume conductor model, known as the cellular composite model, embedded in a four layer model of the retina. Simulations are conducted to investigate the interaction of neural tissue orientation, electrode placement, and stimulation pulse duration and amplitude...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227682/development-of-ocular-viscosity-characterization-method
#7
Shu-Hao Lu, Guo-Zhen Chen, Stanley Y Y Leung, David C C Lam, Shu-Hao Lu, Guo-Zhen Chen, Stanley Y Y Leung, David C C Lam, David C C Lam, Shu-Hao Lu, Guo-Zhen Chen, Stanley Y Y Leung
Glaucoma is the second leading cause for blindness. Irreversible and progressive optic nerve damage results when the intraocular pressure (IOP) exceeds 21 mmHg. The elevated IOP is attributed to blocked fluid drainage from the eye. Methods to measure the IOP are widely available, but methods to measure the viscous response to blocked drainage has yet been developed. An indentation method to characterize the ocular flow is developed in this study. Analysis of the load-relaxation data from indentation tests on drainage-controlled porcine eyes showed that the blocked drainage is correlated with increases in ocular viscosity...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227655/development-of-a-snake-like-dexterous-manipulator-for-skull-base-surgery
#8
Suat Coemert, Anzhu Gao, John P Carey, Mattias F Traeger, Russell H Taylor, Tim C Lueth, Mehran Armand, Suat Coemert, Anzhu Gao, John P Carey, Mattias F Traeger, Russell H Taylor, Tim C Lueth, Mehran Armand, Anzhu Gao, Russell H Taylor, Mattias F Traeger, Mehran Armand, Suat Coemert, Tim C Lueth, John P Carey
Petrous apex lesions constitute considerable surgical challenges due to their location in the skull base and close relationship with critical structures such as inner ear, carotid arteries, facial nerves and jugular bulb. These lesions often cannot be treated completely with rigid tools due to the limited accessibility. We are aiming to develop a snake-like manipulator to assist surgeons with the infralabyrinthine treatment of petrous apex lesions with increased dexterity. This snake-like dexterous manipulator (SDM) with 3...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227645/myoelectric-intuitive-control-and-transcutaneous-electrical-stimulation-of-the-forearm-for-vibrotactile-sensation-feedback-applied-to-a-3d-printed-prosthetic-hand
#9
Enrique I Germany, Esteban J Pino, Pablo E Aqueveque, Enrique I Germany, Esteban J Pino, Pablo E Aqueveque, Enrique I Germany, Pablo E Aqueveque, Esteban J Pino
This paper presents the development of a myoelectric prosthetic hand based on a 3D printed model. A myoelectric control strategy based on artificial neural networks is implemented on a microcontroller for online position estimation. Position estimation performance achieves a correlation index of 0.78. Also a study involving transcutaneous electrical stimulation was performed to provide tactile feedback. A series of stimulations with controlled parameters were tested on five able-body subjects. A single channel stimulator was used, positioning the electrodes 8 cm on the wrist over the ulnar and median nerve...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227560/a-dual-axis-single-proof-mass-angular-accelerometer-for-a-vestibular-prosthesis
#10
Yaesuk Jeong, Hakan Toreyin, Anosh Daruwalla, Pamela Bhatti, Farrokh Ayazi, Yaesuk Jeong, Hakan Toreyin, Anosh Daruwalla, Pamela Bhatti, Farrokh Ayazi, Farrokh Ayazi, Anosh Daruwalla, Yaesuk Jeong, Hakan Toreyin, Pamela Bhatti
A dual-axis single-proof-mass angular accelerometer has been developed for a vestibular prosthesis. Designed to sense head rotations both in the yaw and the pitch planes, the output of the inertial sensor may be coded as amplitude or rate modulated biphasic current pulses to stimulate vestibular nerves. Fabricated with a high aspect ratio commercial process, a sensor with small form factor (1.4 mm × 0.8 mm) is achieved with a scale factor of 95.5 μV/rad/sec(2) and 145.8 μV/rad/sec(2) in the yaw and the pitch planes, respectively...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227512/implantation-and-testing-of-wfma-stimulators-in-macaque
#11
Philip R Trovk, David Frim, Ben Roitberg, Vernon L Towle, Kazutaka Takahashi, Sungjae Suh, Martin Bak, Sam Bredeson, Zhe Hu, Philip R Trovk, David Frim, Ben Roitberg, Vernon L Towle, Kazutaka Takahashi, Sungjae Suh, Martin Bak, Sam Bredeson, Zhe Hu, Vernon L Towle, David Frim, Kazutaka Takahashi, Zhe Hu, Sam Bredeson, Martin Bak, Ben Roitberg, Sungjae Suh
Our on-going work to develop an intracortical visual prosthesis has motivated the design, fabrication, and testing of a Wireless Floating Microelectrode Array (WFMA) stimulator. This implantable device can be used for an electrical stimulation interface in the peripheral and the central nervous system. Previously, its use in a sciatic nerve rodent model was described. Here implantation of two WFMAs in motor cortex of two NHP (macaque - two devices/animal) is presented. Preliminary functional tests show the implanted devices to be fully functional with stimulation-induced motor movements obtained...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227502/posterior-tibial-nerve-stimulation-using-a-wirelessly-powered-system-in-anesthetized-cats
#12
Zainab Moazzam, Austin R Duke, Paul B Yoo, Zainab Moazzam, Austin R Duke, Paul B Yoo, Paul B Yoo, Zainab Moazzam, Austin R Duke
Posterior Tibial Nerve Stimulation (PTNS) is an effective overactive bladder (OAB) therapy where electrical pulses are typically delivered once per week in a 12-week stimulation regime. While the mechanism of action remains unknown, effective long-term delivery of PTNS has recently become a subject of concern. To this end, a multi-contact electrode was surgically placed in the hind limb region of anesthetized cats to (1) investigate the feasibility of using a wirelessly powered system to stimulate PTN afferents and (2) characterize implant-driven effects of stimulation frequency on modulating bladder activity...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227498/effects-of-the-choice-of-reference-on-the-selectivity-of-a-multi-contact-nerve-cuff-electrode
#13
Ryan G L Koh, Jose Zariffa, Ryan G L Koh, Jose Zariffa, Jose Zariffa, Ryan G L Koh
Tripolar referencing is typically used in nerve cuff electrode recordings due to its ability to maximize the signal-to-noise ratio of contacts at the centre, but this may not be the optimal choice for a multi-contact nerve cuff consisting of contacts in off-centre rings. We conducted a simulation study to compare the effects of 3 different reference types on the recording selectivity of a multi-contact nerve cuff: the tripolar reference (TPR), common average reference (CAR), and multiple tripolar references based on consecutive groups of 3 rings (cTPR)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227497/a-wireless-system-with-stimulation-and-recording-capabilities-for-interfacing-peripheral-nerves-in-rodents
#14
P Schonle, F Michoud, N Brun, A Guex, S P Lacour, Q Wang, Q Huang, P Schonle, F Michoud, N Brun, A Guex, S P Lacour, Q Wang, Q Huang, N Brun, A Guex, P Schonle, Q Huang, Q Wang, S P Lacour, F Michoud
Considerable progress has been made in the last decade in implantable bioelectronic neurosystems. Yet most neural implants are used in acute and tethered experimental conditions. Here, we present a preliminary prototype of a multichannel system for simultaneous peripheral nerve stimulation and neural recording. The system comprises miniaturized electronics with a total volume of less then 1.4cm(3) including a 3.7V battery which is expected to last for 94 days of standby operation or 18 hours of continuous recording and stimulation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227435/gelatin-methacrylamide-hydrogel-with-graphene-nanoplatelets-for-neural-cell-laden-3d-bioprinting
#15
Wei Zhu, Brent T Harris, Lijie Grace Zhang, Wei Zhu, Brent T Harris, Lijie Grace Zhang, Wei Zhu, Brent T Harris, Lijie Grace Zhang
Nervous system is extremely complex which leads to rare regrowth of nerves once injury or disease occurs. Advanced 3D bioprinting strategy, which could simultaneously deposit biocompatible materials, cells and supporting components in a layer-by-layer manner, may be a promising solution to address neural damages. Here we presented a printable nano-bioink composed of gelatin methacrylamide (GelMA), neural stem cells, and bioactive graphene nanoplatelets to target nerve tissue regeneration in the assist of stereolithography based 3D bioprinting technique...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227422/a-probabilistic-framework-based-on-slic-superpixel-and-gaussian-processes-for-segmenting-nerves-in-ultrasound-images
#16
Julian Gil Gonzalez, Mauricio A Alvarez, Alvaro A Orozco, Julian Gil Gonzalez, Mauricio A Alvarez, Alvaro A Orozco, Mauricio A Alvarez, Julian Gil Gonzalez, Alvaro A Orozco
We deal with an important problem in the field of anesthesiology known as automatic segmentation of nerve structures depicted in ultrasound images. This is important to aid the experts in anesthesiology, in order to carry out Peripheral Nerve Blocking (PNB). Ultrasound imaging has gained recent interest for performing PNB procedures since it offers a non-invasive visualization of the nerve and the anatomical structures around it. However, the location of these nerves in ultrasound images is a difficult task for the specialist due to the artifacts (i...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227252/linear-methods-for-reducing-emg-contamination-in-peripheral-nerve-motor-decodes
#17
Zachary B Kagan, Suzanne Wendelken, David M Page, Tyler Davis, Douglas T Hutchinson, Gregory A Clark, David J Warren, Zachary B Kagan, Suzanne Wendelken, David M Page, Tyler Davis, Douglas T Hutchinson, Gregory A Clark, David J Warren, Gregory A Clark, Zachary B Kagan, David J Warren, David M Page, Suzanne Wendelken, Tyler Davis, Douglas T Hutchinson
Signals recorded from the peripheral nervous system (PNS) with high channel count penetrating microelectrode arrays, such as the Utah Slanted Electrode Array (USEA), often have electromyographic (EMG) signals contaminating the neural signal. This common-mode signal source may prevent single neural units from successfully being detected, thus hindering motor decode algorithms. Reducing this EMG contamination may lead to more accurate motor decode performance. A virtual reference (VR), created by a weighted linear combination of signals from a subset of all available channels, can be used to reduce this EMG contamination...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227181/co-activation-of-saphenous-nerve-fibers-a-potential-therapeutic-mechanism-of-percutaneous-tibial-nerve-stimulation
#18
Christopher W Elder, Paul B Yoo, Christopher W Elder, Paul B Yoo, Paul B Yoo, Christopher W Elder
Percutaneous tibial nerve stimulation (PTNS) is a minimally invasive and effective treatment for overactive bladder (OAB). However, clinical trials show that positive therapeutic outcomes among patients are difficult to predict (failure rate = 35% to 50%). Inconsistencies in the stimulation amplitudes used clinically and those used in preclinical animal studies led us to hypothesize that OAB therapy involves a secondary bladder-inhibitory pathway. In this paper, we implemented and tested a computer model of the human lower leg that investigated the differential activation of the saphenous nerve (SAFN) and tibial nerve (TN) during percutaneous electrical stimulation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227180/electrical-stimulation-of-the-saphenous-nerve-in-anesthetized-rats-a-novel-therapeutic-approach-to-treating-overactive-bladder
#19
Zainab Moazzam, Paul B Yoo, Zainab Moazzam, Paul B Yoo, Paul B Yoo, Zainab Moazzam
Posterior Tibial Nerve Stimulation (PTNS) is a minimally invasive yet effective therapy for treating overactive bladder (OAB) symptoms with electrical stimulations applied at 20 Hz coupled with amplitudes approximating the foot-twitch threshold (T). However, pre-clinical studies indicate that PTNS-evoked bladder reflexes require stimulation amplitudes exceeding 2T. The objective of this work was to evaluate the presence of secondary low-threshold sensory pathways in the hind-limb region that can be a potential target of activation during clinical PTNS set-up...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227101/high-density-penetrating-electrode-arrays-for-autonomic-nerves
#20
John Burns, Yee-Hsee Hsieh, Andrew Mueller, Juliette Chevallier, T S Sriram, Stephen J Lewis, Daniel Chew, Anil Achyuta, Jason Fiering, John Burns, Yee-Hsee Hsieh, Andrew Mueller, Juliette Chevallier, T S Sriram, Stephen J Lewis, Daniel Chew, Anil Achyuta, Jason Fiering, Daniel Chew, Yee-Hsee Hsieh, Andrew Mueller, Jason Fiering, T S Sriram, Juliette Chevallier, Stephen J Lewis, Anil Achyuta
Electrode arrays for recording and stimulation in the central nervous system have enabled numerous advances in basic science and therapeutic strategies. In particular, micro-fabricated arrays with precision size and spacing offer the benefit of accessing single neurons and permit mapping of neuronal function. Similar advances are envisioned toward understanding the autonomic nervous system and developing therapies based on its modulation, but appropriate electrode arrays are lacking. Here, we present for the first time, a multi-channel electrode array suitable for penetration of peripheral nerves having diameters as small as 0...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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