Margaret G Guo, David L Reynolds, Cheen E Ang, Yingfei Liu, Yang Zhao, Laura K H Donohue, Zurab Siprashvili, Xue Yang, Yongjin Yoo, Smarajit Mondal, Audrey Hong, Jessica Kain, Lindsey Meservey, Tania Fabo, Ibtihal Elfaki, Laura N Kellman, Nathan S Abell, Yash Pershad, Vafa Bayat, Payam Etminani, Mark Holodniy, Daniel H Geschwind, Stephen B Montgomery, Laramie E Duncan, Alexander E Urban, Russ B Altman, Marius Wernig, Paul A Khavari
Noncoding variants of presumed regulatory function contribute to the heritability of neuropsychiatric disease. A total of 2,221 noncoding variants connected to risk for ten neuropsychiatric disorders, including autism spectrum disorder, attention deficit hyperactivity disorder, bipolar disorder, borderline personality disorder, major depression, generalized anxiety disorder, panic disorder, post-traumatic stress disorder, obsessive-compulsive disorder and schizophrenia, were studied in developing human neural cells...
November 2023: Nature Genetics