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Quercetin glycoside

Shuxun Liu, Shaoyang Wang, Guanshen Yuan, Xiaoyu Ouyang, Yaran Liu, Baoqing Zhu, Bolin Zhang
This study investigated the evolution of phenolic compounds of bog bilberry syrup wine during a bottle-aging process, and further estimated the oak chip treatment on the wine color alteration. The wine was macerated with oak chips (2 or 5 g/L under light or medium toasting level) for 20 d and then bottle-aged for 6 mo. Results showed that the oak chip treatment significantly increased the content of phenolic compounds and enhanced the copigmented anthocyanin level before aging. It also resulted in an increase on a(*) and C(*) but a decrease on L(*) , b(*) , and H(*) of the wine...
October 18, 2016: Journal of Food Science
Muhammad Nasimullah Qureshi, Guenther Stecher, Guenther Karl Bonn
Flavonoids have been of considerable importance and interest because of their medicinal activity. Responding to their numerous health benefits, a comparative study on the quantitative determination of total polyphenolic compounds and flavonoids was carried out in Achillea millefolium and Equisetum arvense. Total polyphenolic compounds were quantified by Folin-Ciocalteau method using different solvents in order to prove their extraction efficiency. Focus within total polyphenolic quantification study was placed on the traditional reflux and solvents used were: water, 100% acetone, 100% ethanol, 80% ethanol, 50% methanol and 70% methanol...
September 2016: Pakistan Journal of Pharmaceutical Sciences
Tingjing Zhang, Jianqiang Liang, Panxue Wang, Ying Xu, Yutang Wang, Xinyuan Wei, Mingtao Fan
Phloretin-2'-O-glycosyltransferase (P2'GT) catalyzes the last glycosylation step in the biosynthesis of phloridzin that contributes to the flavor, color and health benefits of apples and processed apple products. In this work, a novel P2'GT of Malus x domestica (MdP2'GT) with a specific activity of 46.82 μkat/Kg protein toward phloretin and uridine diphosphate glucose (UDPG) at an optimal temperature of 30 °C and pH 8.0 was purified from the engineered Pichia pastoris broth to homogeneity by anion exchange chromatography, His-Trap affinity chromatography and gel filtration...
October 12, 2016: Scientific Reports
Bincy Baby, Priya Antony, Walaa Al Halabi, Zahrah Al Homedi, Ranjit Vijayan
Polypharmacology, the discovery or design of drug molecules that can simultaneously interact with multiple targets, is gaining interest in contemporary drug discovery. Serine/threonine kinases are attractive targets for therapeutic intervention in oncology due to their role in cellular phosphorylation and altered expression in cancer. Quercetin, a naturally occurring flavonoid, inhibits multiple cancer cell lines and is used as an anticancer drug in Phase I clinical trial. Quercetin glycosides have also received some attention due to their high bioavailability and activity against various diseases including cancer...
2016: Drug Design, Development and Therapy
Inamullah Hakeem Said, Rohan Lakshmidas Shah, Matthias S Ullrich, Nikolai Kuhnert
A liquid chromatography-mass spectrometry-based method for the quantification of intracellular concentrations of dietary phenolics in bacteria was developed. Using this assay, the time-dependent uptake of quercetin and two of its glycosides into gut microbiota model organisms (Escherichia coli and Bifidobacterium bifidum) under aerobic and anaerobic conditions was studied. For the first time, quantitative data on the uptake of dietary phenols were obtained indicating a time-dependent differential uptake of the dietary compounds...
September 14, 2016: Food & Function
Yifei Wang, Ajay P Singh, Heather N Nelson, Amanda J Kaiser, Nicolette C Reker, Tisha L Hooks, Ted Wilson, Nicholi Vorsa
Cranberry is reported to have health benefits including prevention of urinary tract infections and other chronic diseases, due to the high content of polyphenols including flavonols and flavan-3-ols. The aim of this study was to determine the clearance of flavonol glycosides and flavan-3-ols and/or their metabolites in human urine. Ten healthy women volunteers ingested 240 ml cranberry juice containing flavonol glycosides. Urine samples were collected at 0, 90, 225 and 360 minutes post-ingestion. While flavan-3-ols were not detected, five flavonol glycosides common in cranberry were identified...
October 3, 2016: Journal of Agricultural and Food Chemistry
Antoaneta V Popova, Dirk K Hincha
Flavonoids are a large and diverse group of plant secondary metabolites that are mainly present as glycosides. They are often accumulated in response to abiotic stresses such as UV radiation, drought, cold and freezing. The most extensively studied function of flavonoids is their antioxidant activity although their importance as antioxidants in plants has been questioned. We therefore aim to study effects of flavonols on cellular stress tolerance that are independent of their antioxidant function. Here we investigate the effects of the glycosylated flavonols kaempferol-3-O-glucoside, kaempferol-7-O-glucoside, quercetin-3-O-glucoside and quercetin-3-O-rhamnoside on liposome stability after freezing and drying...
September 24, 2016: Biochimica et Biophysica Acta
Wenli Wang, Ning Li, Jian Wang, Gang Chen, Renbin Huang, Weihong Zhao, Jiayuan Li, Yingying Si
Five chalcanes ((α'R)-2, α'-dimethoxy-furano-[4″, 5'': 3', 4'] chalcane, (α'R, βR)-2', α', β-trimethoxy-furano-[4″, 5'': 3', 4'] chalcane, (α'S, βR)-2', α', β-trimethoxy-furano-[4″, 5'': 3', 4'] chalcane, (α'R, βR)-2', β-dimethoxy-α'-hydroxyethoxy-furano-[4″, 5'': 3', 4'] chalcane, (α'S, βR)-2', β-dimethoxy-α'-hydroxyethoxy-furano-[4″, 5'': 3', 4'] chalcane) and a flavonoid glycoside (3', 7-dihydroxy-6-methoxy-4', 5'-methylenedioxyisoflavone 6-O-β-D- glucopyranoside), together with 15 known components, were isolated from the leaves of Millettia pulchra (Benth) Kurzvar-laxior (Dunn) Z...
November 2016: Phytochemistry
Mary H Grace, Debora Esposito, Michael A Timmers, Jia Xiong, Gad Yousef, Slavko Komarnytsky, Mary Ann Lila
A comprehensive phytochemical analysis was conducted on pistachios to identify the differential contributions of skin and kernel phytochemicals to in vitro bioactivity. Qualitative and quantitative analyses of skin and kernel non-polar extracts (SNP and KNP, respectively) indicated that the major components are fatty acids (696.36 and 879.70 mg g(-1)), phytosterols (16.08 and 4.28 mg g(-1)), and γ-tocopherol (304.17 and 397.10 μg g(-1)). Analysis of the skin and kernel polar extracts (SP and KP, respectively) showed that skin accumulated higher levels of phenolic compounds, especially flavan-3-ols, compared to the kernel...
October 12, 2016: Food & Function
Ole Rechner, Susanne Neugart, Monika Schreiner, Sasa Wu, Hans-Michael Poehling
Light of different wavelengths affects various physiological processes in plants. Short-wavelength radiation (like UV) can activate defense pathways in plants and enhance the biosynthesis of secondary metabolites (such as flavonoids and glucosinolates) responsible for resistance against certain herbivorous insects. The intensity of light-induced, metabolite-based resistance is plant- and insect species-specific and depends on herbivore feeding guild and specialization. In this study, broccoli (Brassica oleracea var...
September 2, 2016: Journal of Chemical Ecology
Shuxia Yan, Xianan Zhang, Xin Wen, Qiang Lv, Changjie Xu, Chongde Sun, Xian Li
Chinese bayberry (Morella rubra Sieb. et Zucc.) fruit have a diverse flavonoid composition responsible for the various medicinal activities, including anti-diabetes. In the present study, efficient simultaneous purification of four flavonoid glycosides, i.e., cyanidin-3-O-glucoside (1), myricetin-3-O-rhamnoside (2), quercetin-3-O-galactoside (3), quercetin-3-O-rhamnoside (4), from Chinese bayberry pulp was established by the combination of solid phase extract (SPE) by C18 Sep-Pak(®) cartridge column chromatography and semi-preparative HPLC (Prep-HPLC), which was followed by HPLC and LC-MS identification...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Claudia Engelhardt, Frank Petereit, Matthias Lechtenberg, Ursula Liefländer-Wulf, Andreas Hensel
The upper aerial parts and leaf tips of Myrothamnus flabellifolia Welw. (Myrothamnaceae), a resurrection plant indigenous to southern Africa, are used in African traditional medicine for infections of the respiratory and urinary system as well as for inflammation of mucosa and skin. Within a phytochemical investigation of the herbal material from M. flabellifolia the flavonoid fraction was shown to contain quercetin 10 as well as the respective 3-O-β-d-galactosides, glucosides, -glucuronides and 3-O-α-l-rhamnosides of quercetin (6, 7, 8, 26) and kaempferol (1, 2, 3, 9)...
October 2016: Fitoterapia
Shahira M Ezzat, Maha M Salama, Sayed H Seif El-Din, Samira Saleh, Naglaa M El-Lakkany, Olfat A Hammam, Maha B Salem, Sanaa S Botros
CONTEXT: Hibiscus sabdariffa L. (Malvaceae) is a common traditional tea that has many biological activities. OBJECTIVES: To evaluate the hepatoprotective effect and study the metabolic profile of the anthocyanin-rich extract of H. sabdariffa calyces (HSARE). MATERIALS AND METHODS: The hepatoprotective activity of HSARE was assessed (100 mg/kg/d for 4 weeks) by examining the hepatic, inflammatory, oxidative stress markers and performing a histopathological examination in rats with thioacetamide (TAA)-induced hepatotoxicity...
August 26, 2016: Pharmaceutical Biology
Mohamed I S Abdelhady, Usama Shaheen, Ammar Bader, Mahmoud A Youns
BACKGROUND: Sucrase enzyme inhibitor considered as an oral anti-diabetic therapy that delays the absorption of eaten carbohydrates, reducing the postprandial glucose and insulin peaks to reach normoglycemia. MATERIALS AND METHODS: Chromatographic fractionation of the hydroalcoholic extract of leaves of Azadirachta indica growing in KSA, followed by in-vitro assay of sucrase enzyme inhibition activity. RESULTS: This investigation led to the isolation of a new remarkable sucrase enzyme inhibitor; 4'-methyl Quercetin-7-O-β-D-glucuronopyranoside (1) alongside with four known compounds; 2,3-hexahydroxydiphenoyl-(α/β)-D-(4)C1-glucopyranose (2), Avicularin (3), Castalagin (4) and Quercetin-3-O-glucoside (5)...
May 2016: Pharmacognosy Magazine
Amit Kumar Sharma, Mayank Gangwar, Dharmendra Kumar, Gopal Nath, Akhoury Sudhir Kumar Sinha, Yamini Bhushan Tripathi
OBJECTIVE: This study aims to evaluate the antimicrobial activity, phytochemical studies and thin layer chromatography analysis of machine oil, hexane extract of seed oil and methanol extract of presscake & latex of Jatropha curcas Linn (family Euphorbiaceae). MATERIALS AND METHODS: J. curcas extracts were subjected to preliminary qualitative phytochemical screening to detect the major phytochemicals followed by its reducing power and content of phenol and flavonoids in different fractions...
July 2016: Avicenna Journal of Phytomedicine
F Ferreres, S C Q Magalhães, A Gil-Izquierdo, P Valentão, A R J Cabrita, A J M Fonseca, P B Andrade
Lathyrus cicera L. seeds are of interest for food and feed purposes. Despite the recognized antioxidant activity of the seeds, arising from the phenolic fraction, their phenolic compounds have not been studied in depth yet. Therefore, to determine the phenolics profile of these seeds, a target analysis was performed using high-performance liquid chromatography coupled to photodiode-array detection and electrospray ionization/ion trap mass spectrometry (HPLC-DAD-ESI/MS(n)). Thirty-seven glycosylated flavonoids were identified for the first time in the seeds of this species and, according to their MS fragmentation, clustered in flavonol-3-O-di-/tri-glycosides-7-O-rhamnosides and other flavonol-glycosides, and flavonol-3-O-(cinnamoyl)glycoside-7-O-rhamnosides, flavonol-3-O-(dihydrophaseoyl, cinnamoyl)glycoside-7-O-rhamnosides and flavonol-3-O-(malonyl)glycoside-7-O-rhamnosides...
January 1, 2017: Food Chemistry
Tania Pozzo, Javier Romero-García, Magda Faijes, Antoni Planas, Eva Nordberg Karlsson
The thermostable β-glucosidase from Thermotoga neapolitana, TnBgl3B, is a monomeric three-domain representative from glycoside hydrolase family 3 (GH3). By using chemical reactivation with exogenous nucleophiles in previous studies with TnBg13B, the catalytic nucleophile (D242) and corresponding acid/base residue (E458) were determined. Identifying these residues led to the attempt of converting TnBgl3B into a β-glucosynthase, where three nucleophilic variants were created (TnBgl3B_D242G, TnBgl3B_D242A, TnBgl3B_D242S) and all of them failed to exhibit glucosynthase activity...
August 3, 2016: Glycobiology
Mirko De Rosso, Stefano Soligo, Annarita Panighel, Roberto Carraro, Antonio Dalla Vedova, Itay Maoz, Diego Tomasi, Riccardo Flamini
Grape dehydration is an oenological process used for the production of high-quality reinforced and sweet wines. Corvina and Raboso Piave are two red grape varieties used for production of high-quality Italian wines, such as Recioto, Amarone di Valpolicella and Raboso Passito. Changes of polyphenolic composition of the grapes as a consequence of the withering were studied by ultra-high performance liquid chromatography-quadrupole time of flight mass spectrometry (UHPLC/QTOF); for identification of compounds a homemade HR-MS database of grape and wine metabolites, was used...
September 2016: Journal of Mass Spectrometry: JMS
Jiacheng Huang, Long Chen, Bin Xue, Qianyue Liu, Shiyi Ou, Yong Wang, Xichun Peng
The impact of flavonoids has been discussed on the relative viability of bacterial groups in human microbiota. This study was aimed to compare the modulation of various flavonoids, including quercetin, catechin and puerarin, on gut microbiota culture in vitro, and analyze the interactions between bacterial species using fructo-oligosaccharide (FOS) as carbon source under the stress of flavonoids. Three plant flavonoids, quercetin, catechin, and puerarin, were added into multispecies culture to ferment for 24 h, respectively...
September 2016: Journal of Food Science
Le-Yue Du, Jin-Hua Tao, Jiang Shu, Da-Wei Qian, Jian-Ming Guo, Jin-Ao Duan
Flos Abelmoschus manihot is a traditional herbal medicine widely used in clinical practice to tackle chronic kidney disease (CKD) for thousands of years. Nowadays, many researches indicate that gut bacteria are closely related to the progression of CKD and CKD-related complications. In this study, UPLC-Q-TOF/MS coupled with the MetaboLynx(TM) software, was established and successfully applied to firstly investigate the metabolites and metabolic profile of Flos Abelmoschus manihot extract by intestinal bacteria from normal and CKD rats...
July 23, 2016: Biomedical Chromatography: BMC
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