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Quercetin glycoside

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https://www.readbyqxmd.com/read/28431473/structures-and-bioactivities-of-seven-flavonoids-from-osmanthus-fragrans-jinqiu-essential-oil-extraction-residues
#1
Jiang-Lian Zhou, Xian-Ying Fang, Jing-Qiu Wang, Lin-Guo Zhao, Yi Li, Feng Tang, Yong-De Yue
Osmanthus fragrans are well-known for their fragrance, but it is wasteful if to discard O. fragrans flower after extracting their essential oils. In this paper, we found that O. fragrans flower residues were rich in flavonoids. Six flavonoids and one phenylethanoid glycoside were isolated from the ethanol extract of O. fragrans flower residues, identified as quercetin (1), rutin (2), verbascoside (3), genistin (4), kaempferol (5), isorhamnetin (6) and naringin (7). In bioactivity study, kaempferol (IC50 = 1...
April 21, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28412883/polyphenols-of-virgin-coconut-oil-prevent-pro-oxidant-mediated-cell-death
#2
Soorya Parathodi Illam, Arunaksharan Narayanankutty, Achuthan C Raghavamenon
Virgin coconut oil (VCO), extracted from the fresh coconut kernel, is a food supplement enriched with medium chain saturated fatty acids and polyphenolic antioxidants. It is reported to have several health benefits including lipid lowering, antioxidant and anti-inflammatory activities. The pharmacological benefits of VCO have been attributed to its polyphenol contents (VCOP), the mechanistic basis of which is less explored. LC/MS analysis of VCOP documented the presence of gallic acid, ferulic acid, quercetin, methyl catechin, dihydrokaempferol, and myricetin glycoside...
April 16, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28407916/protective-property-of-mulberry-digest-against-oxidative-stress-a-potential-approach-to-ameliorate-dietary-acrylamide-induced-cytotoxicity
#3
Linxia Zhang, Yang Xu, Yuting Li, Tao Bao, Vemana Gowd, Wei Chen
The aim of this study was investigating the protective effect of mulberry digest (MBD) on acrylamide-induced oxidative stress. Composition analysis of MBD revealed that it contained six major phenolic compounds (quercetin-3-O-rutinoside, quercetin hexoside, quercetin rhamnosylhexoside hexoside, kaempferol rhamnosylhexoside, cyanidin-3-O-glucoside and cyanidin-3-O-rutinoside). After in vitro digestion, the contents of two anthocyanins were both decreased significantly, while the contents of four flavonoid glycosides were all increased...
September 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28388787/antidiabetic-activities-of-an-lc-ms-fingerprinted-aqueous-extract-of-fagonia-cretica-l-in-preclinical-models
#4
Imran Nazir, Nisar Ur Rahman, Zunaira Alvi, M Hafizur Rahman, Jandirk Sendker, Tao Zhang, Neil Frankish, Helen Sheridan
Diabetes mellitus is a chronic disease and one of the most important public health challenges facing mankind. Fagonia cretica is a medicinal plant used widely in the Punjab in Pakistan. A recent survey has demonstrated that traditional healers and herbalists frequently use this plant to treat diabetes. In the current study, the traditional medicine was prepared as a tea, and the profile of the main metabolites present in the traditional medicine was analysed via LC/MS/MS. The extract was shown to contain a number of phenolic glycosides including quercetin-3-O-rutinoside, kaempferol-3-O-rutinoside, kaempferol-3-O-glycoside, kaempferol-3(6'-malonylglucoside), isorhamnetin-3-O-rutinoside, and isorhamnetin 3-(6″-malonylglucoside) in addition to two unidentified sulphonated saponins...
April 7, 2017: Planta Medica
https://www.readbyqxmd.com/read/28373417/structure-activity-relationships-of-methylquercetin-on-anti-migration-and-anti-proliferation-activity-in-b16-melanoma-cells
#5
Kosei Yamauchi, Tohru Mitsunaga, Syeda H Afroze, Mohammad N Uddin
BACKGROUND: Melanoma is a malignant skin tumor and quercetin has been reported to inhibit metastasis. A quercetin glycoside and 7 methylquercetins were synthesized from rutin to investigate structure-activity relationships. MATERIALS AND METHODS: We evaluated the anti-proliferative and anti-migration activity of quercetin glycoside and 7 methylquercetins in murine B16 melanoma cells by commercially available kits. We also examined the effect of these compounds on growth of human fibroblast cells to evaluate cytotoxicity...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28357634/bioactive-flavonoids-from-flos-sophorae
#6
Wenzhong Shi, Lili Liu, Jian Li, Lu Qu, Xu Pang, Haiyang Yu, Yi Zhang, Tao Wang
Three new flavonoid glycosides-soyaflavonosides A (1), B (2), and C (3)-together with 23 known ones were obtained from the 70% EtOH extract of Flos Sophorae (Sophora japonica, Leguminosae). Their structures were elucidated by chemical and spectroscopic methods. Among the known isolates, 14, 18, 20, 22, and 26 were isolated from the Sophora genus for the first time; 12, 19, 24, and 25 were obtained from the species firstly. Moreover, NMR data for compounds 18 and 26 are reported for the first time here. Meanwhile, compounds 4, 8-13, 15, 16, 19, 21, and 22 presented obvious inhibitory effects on TG accumulation in HepG2 cells...
March 29, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28332768/separation-of-caffeoylquinic-acids-and-flavonoids-from-asteris-souliei-by-high-performance-counter-current-chromatography-and-their-anti-inflammatory-activity-in-vitro
#7
Qiang Zhang, He-Ying Pei, Kai Chen, Huan Tang, Bo Wu, Ming-Hai Tang, Ai-Hua Peng, Hao-Yu Ye, Li-Juan Chen
Eleven compounds were successfully separated from Asteris souliei by using a two-step high-performance counter-current chromatography method. The first step involved a reversed phase isocratic counter-current chromatography separation using hexane/ethyl acetate/methanol/water (1:0.8:1:1 v/v/v/v), which produced three fractions, the first two of which were mixtures. The second step used step-gradient reversed-phase counter-current chromatography with hexane/butanol/ethyl acetate/methanol/water (1:0.5:3.5:1:4 v/v/v/v/v) initially followed by hexane/ethyl acetate/methanol/water (1:2:1:2 v/v/v/v) to separate Fraction 1 into seven compounds; and hexane/ethyl acetate/methanol/water (1:1:1:1...
March 23, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28320327/metabolomics-analysis-reveals-the-metabolic-and-functional-roles-of-flavonoids-in-light-sensitive-tea-leaves
#8
Qunfeng Zhang, Meiya Liu, Jianyun Ruan
BACKGROUND: As the predominant secondary metabolic pathway in tea plants, flavonoid biosynthesis increases with increasing temperature and illumination. However, the concentration of most flavonoids decreases greatly in light-sensitive tea leaves when they are exposed to light, which further improves tea quality. To reveal the metabolism and potential functions of flavonoids in tea leaves, a natural light-sensitive tea mutant (Huangjinya) cultivated under different light conditions was subjected to metabolomics analysis...
March 20, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28317733/antioxidant-activities-and-structural-characterization-of-flavonol-o-glycosides-from-seeds-of-japanese-horse-chestnut-aesculus-turbinata-blume
#9
Hideto Kimura, Satoshi Ogawa, Tomoe Ishihara, Mahoko Maruoka, Shota Tokuyama-Nakai, Mitsuo Jisaka, Kazushige Yokota
We attempted to evaluate the contents and distribution of antioxidants in the whole seeds, seed shells, and peeled seeds of the Japanese horse chestnut. The seed shells exhibited the highest antioxidant activities due to the presence of highly polymeric proanthocyanidins as we have reported recently. On the other hand, the peeled seeds predominantly contained flavonols such as quercetin and kaempferol at a high level of 66.7% of total polyphenols, also contributing to the predominant antioxidant activities...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28294257/protein-bound-vaccinium-fruit-polyphenols-decrease-ige-binding-to-peanut-allergens-and-rbl-2h3-mast-cell-degranulation-in-vitro
#10
Nathalie J Plundrich, Rishipal R Bansode, E Allen Foegeding, Leonard L Williams, Mary Ann Lila
Peanut allergy is a worldwide health concern. In this study, the natural binding properties of plant-derived polyphenols to proteins was leveraged to produce stable protein-polyphenol complexes comprised of peanut proteins and cranberry (Vaccinium macrocarpon Ait.) or lowbush blueberry (Vaccinium angustifolium Ait.) pomace polyphenols. Protein-bound and free polyphenols were characterized and quantified by multistep extraction of polyphenols from protein-polyphenol complexes. Immunoblotting was performed with peanut-allergic plasma to determine peanut protein-specific IgE binding to unmodified peanut protein, or to peanut protein-polyphenol complexes...
April 19, 2017: Food & Function
https://www.readbyqxmd.com/read/28278644/phytochemical-components-and-biological-activities-of-silene-arenarioides-desf
#11
Lynda Golea, Mohammed Benkhaled, Catherine Lavaud, Christophe Long, Hamada Haba
In this study, six known compounds 1-6 were isolated from the aerial parts of Silene arenarioides Desf. using different chromatographic methods. The structures of these compounds were identified as maltol glycoside (1), soyacerebroside I (2), chrysin (3), apigenin (4), quercetin (5) and stigmasterol glucoside (6). The compounds (1) and (2) are reported for the first time from this genus. The isolated compounds were determined using NMR techniques ((1)H NMR, (13)C NMR, COSY, HSQC and HMBC) and mass spectroscopy (ESI-MS)...
February 24, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28262394/the-in-vitro-anthelmintic-properties-of-browse-plant-species-against-haemonchus-contortus-is-determined-by-the-polyphenol-content-and-composition
#12
G Mengistu, H Hoste, M Karonen, J-P Salminen, W H Hendriks, W F Pellikaan
The aims of the present study were to (a) evaluate the anthelmintic activity of 10 East African browse plant extracts, (b) examine their role in inhibition of Haemonchus contortus larval exsheathment, (c) establish relationship between inhibition of larval exsheathment and browse plant extract polyphenol composition. Acetone/water (70/30%) extracts of air dried leaves of Acacia etbaica, Cadaba farinosa, Capparis tomentosa, Dichrostachys cinerea, Dodonaea angustifolia, Euclea racemosa, Maerua angolensis, Maytenus senegalensis, Rhus natalensis and Senna singueana were used...
December 31, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/28256049/exploratory-studies-on-the-in-vitro-anti-inflammatory-potential-of-two-herbal-teas-annona-muricata-l-and-jasminum-grandiflorum-l-and-relation-with-their-phenolic-composition
#13
Andreia P Oliveira, Ivone Sá, David M Pereira, Rui F Gonçalves, Paula B Andrade, Patrícia Valentão
The need of new anti-inflammatory drugs has led to the search for safer and more potent molecules in distinct sources, such as natural products. This work aimed to explore the anti-inflammatory potential of aqueous extracts from two herbal teas (Annona muricata L. and Jasminum grandiflorum L.) in RAW 264.7 macrophages cells and in cell-free assays. Furthermore, the phenolic composition of both extracts and of their hydrolysates was characterized by HPLC-DAD, in order to establish possible relationships with the biological activity...
March 2, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28245624/flavonoids-from-agrimonia-pilosa-ledeb-free-radical-scavenging-and-dna-oxidative-damage-protection-activities-and-analysis-of-bioactivity-structure-relationship-based-on-molecular-and-electronic-structures
#14
Liancai Zhu, Jinqiu Chen, Jun Tan, Xi Liu, Bochu Wang
To clarify the substantial basis of the excellent antioxidant capacity of Agrimonia pilosa Ledeb. Fourteen flavonoids were isolated and identified from Agrimonia pilosa Ledeb, seven of which have notable DPPH radical scavenging activities, i.e., catechin, luteolin, quercetin, quercitrin, hyperoside, rutin, luteolin-7-O-β-glucoside with IC50 values of 5.06, 7.29, 4.36, 7.12, 6.34, 6.36 and 8.12 µM, respectively. The DNA nicking assay showed that five flavonoids from Agrimonia pilosa Ledeb-taxifolin, catechin, hyperoside, quercitrin and rutin-have good protective activity against DNA oxidative damage...
February 26, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28221885/antibacterial-and-antiadhesive-activities-of-extracts-from-edible-plants-against-soft-drink-spoilage-by-asaia-spp
#15
Hubert Antolak, Agata Czyzowska, Dorota Kregiel
This study was conducted to investigate the antibacterial and antiadhesive activities of ethanol extracts from five edible plant parts: cinnamon bark ( Cinnamomum zeylanicum ), licorice root ( Glycyrrhiza radix ), nettle leaves ( Urtica dioica ), green tea leaves ( Camellia sinensis ), and elderberry flowers ( Sambucus nigra ). The chemical constituents of the extracts were identified using high-performance liquid chromatography and liquid chromatography plus mass spectrometry. Six strains of Asaia lannensis and Asaia bogorensis bacteria isolated from spoiled commercial fruit-flavored noncarbonated mineral water were used...
January 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28220704/functional-characterization-of-a-new-tea-camellia-sinensis-flavonoid-glycosyltransferase
#16
Xianqian Zhao, Peiqiang Wang, Mingzhuo Li, Yeru Wang, Xiaolan Jiang, Lilan Cui, Yumei Qian, Juhua Zhuang, Liping Gao, Tao Xia
Tea (Camellia sinensis) is an important commercial crop, in which the high content of flavonoids provides health benefits. A flavonoid glycosyltransferase (CsUGT73A20), belonging to cluster IIIa, was isolated from tea plant. The recombinant CsUGT73A20 in Escherichia coli exhibited a broad substrate tolerance toward multiple flavonoids. Among them, kaempferol was the optimal substrate compared to quercetin, myricetin, naringenin, apigenin, and kaempferide. However, no product was detected when UDP-galactose was used as the sugar donor...
March 3, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28218702/phytochemical-study-of-tapirira-guianensis-leaves-guided-by-vasodilatory-and-antioxidant-activities
#17
Amélia M G Rodrigues, Denise O Guimarães, Tatiana U P Konno, Luzineide W Tinoco, Thiago Barth, Fernando A Aguiar, Norberto P Lopes, Ivana C R Leal, Juliana M Raimundo, Michelle F Muzitano
The aim of this research was to perform a phytochemical study of the methanol leaves extract of T. guianensis (MET) guided by vasodilatory and antioxidant activities. The chemical profile of MET and the ethyl acetate fraction (EA fraction) was determined by HPLC-UV-MS and EA fraction guided fractionation by reverse-phase chromatography. The vasorelaxant effects of MET, fractions, sub-fractions and constituents were assessed on rat aorta pre-contracted with phenylephrine. Antioxidant activity was evaluated by using a DPPH assay...
February 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28178217/flavonoid-composition-and-antitumor-activity-of-bee-bread-collected-in-northeast-portugal
#18
Filipa Sobral, Ricardo C Calhelha, Lillian Barros, Montserrat Dueñas, Andreia Tomás, Celestino Santos-Buelga, Miguel Vilas-Boas, Isabel C F R Ferreira
Bee bread (BB) is a fermented mixture of plant pollen, honey, and bee saliva that worker bees use as food for larvae, and for young bees to produce royal jelly. In the present study, five BB samples, collected from Apis mellifera iberiensis hives located in different apiaries near Bragança, in the northeast region of Portugal, and one BB commercial sample were characterized by high-performance liquid chromatography coupled to a diode array detector and electrospray mass spectrometry (HPLC-DAD-ESI/MS) in terms of phenolic compounds, such as flavonoid glycoside derivatives...
February 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28165379/in-vitro-lipophilic-antioxidant-capacity-antidiabetic-and-antibacterial-activity-of-citrus-fruits-extracts-from-aceh-indonesia
#19
Ernawita, Ruri Agung Wahyuono, Jana Hesse, Uta-Christina Hipler, Peter Elsner, Volker Böhm
This study reports in vitro lipophilic antioxidant, inhibition of α-amylase and antibacterial activities of extracts of peel and pulp of citrus samples from Aceh, Indonesia. HPLC (high-performance liquid chromatography), phytochemical, and FTIR (fourier transform infrared) analysis detected carotenoids, flavonoids, phenolic acids and terpenoids, contributing to the biological potencies. Most peel and pulp extracts contained lutein and lower concentrations of zeaxanthin, α-carotene, β-carotene and β-cryptoxanthin...
February 3, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28142197/crystal-structure-of-%C3%AE-glucosidase-1a-from-thermotoga-neapolitana-and-comparison-of-active-site-mutants-for-hydrolysis-of-flavonoid-glucosides
#20
Tejas S Kulkarni, Samiullah Khan, Rodrigo Villagomez, Tahir Mahmood, Sofia Lindahl, Derek T Logan, Javier A Linares-Pastén, Eva Nordberg Karlsson
The β-glucosidase TnBgl1A catalyses hydrolysis of O-linked terminal β-glycosidic bonds at the nonreducing end of glycosides/oligosaccharides. Enzymes with this specificity have potential in lignocellulose conversion (degrading cellobiose to glucose) and conversion of bioactive flavonoids (modification of glycosylation results in modulation of bioavailability). Previous work has shown TnBgl1A to hydrolyse 3, 4' and 7 glucosylation in flavonoids, and although conversion of 3-glucosylated substrate to aglycone was low, it was improved by mutagenesis of residue N220...
January 31, 2017: Proteins
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