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Quercetin glycoside

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https://www.readbyqxmd.com/read/27896020/identification-of-phenolic-secondary-metabolites-from-schotia-brachypetala-sond-fabaceae-and-demonstration-of-their-antioxidant-activities-in-caenorhabditis-elegans
#1
Mansour Sobeh, Esraa ElHawary, Herbenya Peixoto, Rola M Labib, Heba Handoussa, Noha Swilam, Ahmed H El-Khatib, Farukh Sharapov, Tamer Mohamed, Sonja Krstin, Michael W Linscheid, Abdel Nasser Singab, Michael Wink, Nahla Ayoub
BACKGROUND: Schotia brachypetala Sond. (Fabaceae) is an endemic tree of Southern Africa whose phytochemistry and pharmacology were slightly studied. The present work aimed at profiling the major phenolics compounds present in the hydro-alcohol extract from S. brachypetala leaves (SBE) using LC/HRESI/MS/MS and NMR and prove their antioxidant capabilities using novel methods. METHODS: In vitro assays; DPPH, TEAC persulfate decolorizing kinetic and FRAP assays, and in vivo assays: Caenorhabditis elegans strains maintenance, Intracellular ROS in C...
2016: PeerJ
https://www.readbyqxmd.com/read/27866749/inter-population-and-inter-organ-distribution-of-the-main-polyphenolic-compounds-of-epilobium-angustifolium
#2
Nicolas Baert, Jorma Kim, Maarit Karonen, Juha-Pekka Salminen
Rosebay willowherb (Epilobium angustifolium) contains large amounts of polyphenolic compounds, including tellimagrandin I-based oligomeric ellagitannins (ETs). The aim of this study was to assess the interpopulational and inter-organ variability of the polyphenol fingerprint of E. angustifolium. Seven ETs, 11 flavonol glycosides and neochlorogenic acid were quantified by UHPLC-DAD-ESI-QqQ-MS in the leaves, flowers and stem parts of plants from 10 populations. Total polyphenol content of leaves and flowers ranged from 150 to 200 mg/g dry wt, of which 90% was constituted by dimeric to heptameric ETs...
November 17, 2016: Phytochemistry
https://www.readbyqxmd.com/read/27861139/in-vitro-antioxidant-and-anti-inflammatory-activities-of-isolated-compounds-of-ethanol-extract-from-sanchezia-speciosa-leonard-s-leaves
#3
Tung Bui Thanh, Loi Vu Duc, Hai Nguyen Thanh, Vung Nguyen Tien
BACKGROUND: Sanchezia speciosa has been used in traditional medicine for gastritis treatment in Vietnam. Some phytochemical study showed that S. speciosa contains high amounts of flavonoids and cardiac glycoside compounds. In the present study, we isolated four compounds from the ethanol extract of the S. speciosa leaf, and we evaluated the in vitro antioxidant and anti-inflammatory effect of the isolated compound from the ethanol extract of the S. speciosa leaf. METHODS: The leaf of S...
November 18, 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27855899/phenolic-compounds-extracted-by-acidic-aqueous-ethanol-from-berries-and-leaves-of-different-berry-plants
#4
Ye Tian, Jaana Liimatainen, Aino-Liisa Alanne, Anni Lindstedt, Pengzhan Liu, Jari Sinkkonen, Heikki Kallio, Baoru Yang
Phenolic compounds of berries and leaves of thirteen various plant species were extracted with aqueous ethanol and analyzed with UPLC-DAD-ESI-MS, HPLC-DAD, and NMR. The total content of phenolics was consistently higher in leaves than in berries (25-7856 vs. 28-711mg/100g fresh weight). Sea buckthorn leaves were richest in phenolic compounds (7856mg/100g f.w.) with ellagitannins as the dominant compound class. Sea buckthorn berries contained mostly isorhamnetin glycosides, whereas quercetin glycosides were typically abundant in most samples investigated...
April 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27854196/determination-of-flavonoids-polyphenols-and-antioxidant-activity-of-tephrosia-purpurea-a-seasonal-study
#5
Madan Mohan Pandey, Sayyada Khatoon, Subha Rastogi, Ajay Kumar Singh Rawat
OBJECTIVE: Tephrosia purpurea (Linn·) Pers. is widely used in traditional medicine to treat liver disorders, febrile attacks, enlargement and obstruction of liver, spleen, and kidney. In the present study, investigations were carried out to determine the seasonal impact on the content of flavonoid glycosides and on antioxidant activities so as to identify the optimal time of harvesting. METHODS: The plant materials were collected in different seasons during 2013-2014...
November 2016: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27845891/curviflorside-and-curviflorin-new-naphthalene-glycoside-and-flavanol-from-plicosepalus-curviflorus
#6
Nawal M Al Musayeib, Sabrin R M Ibrahim, Musarat Amina, Gadah A Al Hamoud, Gamal A Mohamed
The naphthalene glycosidecurviflorside [1,5-dihydroxy-8-methoxynaphthalene-2-O-β-D-xylopyranoside] (3) and the flavanol curviflorin [(+)-catechin-7-O-3″,4″-dihydroxybenzoate] (4), along with two known flavonoids: (+)-catechin (1) and quercetin (2) were isolated from the shoots of Plicosepalu scurviflorus Benth. (Loranthaceae) growing in Saudi Arabia and the chemical structures were elucidated by 2D-NMR spectroscopy.
November 15, 2016: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/27794607/melibiose-a-non-digestible-disaccharide-promotes-absorption-of-quercetin-glycosides-in-rat-small-intestine
#7
Seiya Tanaka, Aki Shinoki, Hiroshi Hara
We demonstrated that melibiose, a non-digestible disaccharide composed of galactose and glucose with α-1,6 glycoside linkage, promotes the absorption of water soluble quercetin glycosides in ligated small intestinal loop of anesthetized rats. Water soluble quercetin glycoside, a quercetin-3-Ο-glucoside mixture (Q3GM), includes quercetin-3-Ο-glucoside (Q3G, 31.9%), mono (21.2%) and di (17.1%), glucose adducts with α-1,4 linkages. After instillation of Q3GM into the intestinal loop with or without melibiose, the plasma concentration of quercetin derivatives in the portal blood, was considerably higher in the melibiose group at 60 min...
October 31, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27776529/biosynthesis-of-three-n-acetylaminosugar-conjugated-flavonoids-using-engineered-escherichia-coli
#8
A Ra Cho, Su Jin Lee, Bong Gyu Kim, Joong-Hoon Ahn
BACKGROUND: Nucleotide sugars serve as sugar donors for the synthesis of various glycones. The biological and chemical properties of glycones can be altered depending which sugar is attached. Bacteria synthesize unusual nucleotide sugars. A novel nucleotide sugar can be synthesized in Escherichia coli by introducing nucleotide biosynthetic genes from other microorganisms into E. coli. The engineered E. coli strains can be used as a platform for the synthesis of novel glycones. RESULTS: Four genes, Pdeg (UDP-N-acetylglucosamine C4,6-dehydratase), Preq (UDP-4-reductase), UDP-GlcNAc 6-DH (UDP-N-acetylglucosamine 6-dehydrogenase), and UXNAcS (UDP-N-acetylxylosamine synthase), were employed to synthesize UDP-quinovosamine, UDP-N-acetylglucosaminuronic acid, and UDP-N-acetylxylosamine in E...
October 24, 2016: Microbial Cell Factories
https://www.readbyqxmd.com/read/27755647/effect-of-oak-chips-on-evolution-of-phenolic-compounds-and-color-attributes-of-bog-bilberry-syrup-wine-during-bottle-aging
#9
Shuxun Liu, Shaoyang Wang, Guanshen Yuan, Xiaoyu Ouyang, Yaran Liu, Baoqing Zhu, Bolin Zhang
This study investigated the evolution of phenolic compounds of bog bilberry syrup wine during a bottle-aging process, and further estimated the oak chip treatment on the wine color alteration. The wine was macerated with oak chips (2 or 5 g/L under light or medium toasting level) for 20 d and then bottle-aged for 6 mo. Results showed that the oak chip treatment significantly increased the content of phenolic compounds and enhanced the copigmented anthocyanin level before aging. It also resulted in an increase on a(*) and C(*) but a decrease on L(*) , b(*) , and H(*) of the wine...
October 18, 2016: Journal of Food Science
https://www.readbyqxmd.com/read/27731806/quantification-of-polyphenolic-compounds-and-flavonoids-in-achillea-millefolium-and-equisetum-arvense
#10
Muhammad Nasimullah Qureshi, Guenther Stecher, Guenther Karl Bonn
Flavonoids have been of considerable importance and interest because of their medicinal activity. Responding to their numerous health benefits, a comparative study on the quantitative determination of total polyphenolic compounds and flavonoids was carried out in Achillea millefolium and Equisetum arvense. Total polyphenolic compounds were quantified by Folin-Ciocalteau method using different solvents in order to prove their extraction efficiency. Focus within total polyphenolic quantification study was placed on the traditional reflux and solvents used were: water, 100% acetone, 100% ethanol, 80% ethanol, 50% methanol and 70% methanol...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27731384/purification-and-characterization-of-a-novel-phloretin-2-o-glycosyltransferase-favoring-phloridzin-biosynthesis
#11
Tingjing Zhang, Jianqiang Liang, Panxue Wang, Ying Xu, Yutang Wang, Xinyuan Wei, Mingtao Fan
Phloretin-2'-O-glycosyltransferase (P2'GT) catalyzes the last glycosylation step in the biosynthesis of phloridzin that contributes to the flavor, color and health benefits of apples and processed apple products. In this work, a novel P2'GT of Malus x domestica (MdP2'GT) with a specific activity of 46.82 μkat/Kg protein toward phloretin and uridine diphosphate glucose (UDPG) at an optimal temperature of 30 °C and pH 8.0 was purified from the engineered Pichia pastoris broth to homogeneity by anion exchange chromatography, His-Trap affinity chromatography and gel filtration...
October 12, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27729770/structural-insights-into-the-polypharmacological-activity-of-quercetin-on-serine-threonine-kinases
#12
Bincy Baby, Priya Antony, Walaa Al Halabi, Zahrah Al Homedi, Ranjit Vijayan
Polypharmacology, the discovery or design of drug molecules that can simultaneously interact with multiple targets, is gaining interest in contemporary drug discovery. Serine/threonine kinases are attractive targets for therapeutic intervention in oncology due to their role in cellular phosphorylation and altered expression in cancer. Quercetin, a naturally occurring flavonoid, inhibits multiple cancer cell lines and is used as an anticancer drug in Phase I clinical trial. Quercetin glycosides have also received some attention due to their high bioavailability and activity against various diseases including cancer...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27711903/quantification-of-microbial-uptake-of-quercetin-and-its-derivatives-using-an-uhplc-esi-qtof-mass-spectrometry-assay
#13
Inamullah Hakeem Said, Rohan Lakshmidas Shah, Matthias S Ullrich, Nikolai Kuhnert
A liquid chromatography-mass spectrometry-based method for the quantification of intracellular concentrations of dietary phenolics in bacteria was developed. Using this assay, the time-dependent uptake of quercetin and two of its glycosides into gut microbiota model organisms (Escherichia coli and Bifidobacterium bifidum) under aerobic and anaerobic conditions was studied. For the first time, quantitative data on the uptake of dietary phenols were obtained indicating a time-dependent differential uptake of the dietary compounds...
September 14, 2016: Food & Function
https://www.readbyqxmd.com/read/27690414/urinary-clearance-of-cranberry-flavonol-glycosides-in-humans
#14
Yifei Wang, Ajay P Singh, Heather N Nelson, Amanda J Kaiser, Nicolette C Reker, Tisha L Hooks, Ted Wilson, Nicholi Vorsa
Cranberry is reported to have health benefits including prevention of urinary tract infections and other chronic diseases, due to the high content of polyphenols including flavonols and flavan-3-ols. The aim of this study was to determine the clearance of flavonol glycosides and flavan-3-ols and/or their metabolites in human urine. Ten healthy women volunteers ingested 240 ml cranberry juice containing flavonol glycosides. Urine samples were collected at 0, 90, 225 and 360 minutes post-ingestion. While flavan-3-ols were not detected, five flavonol glycosides common in cranberry were identified...
October 3, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27677212/effects-of-flavonol-glycosides-on-liposome-stability-during-freezing-and-drying
#15
Antoaneta V Popova, Dirk K Hincha
Flavonoids are a large and diverse group of plant secondary metabolites that are mainly present as glycosides. They are often accumulated in response to abiotic stresses such as UV radiation, drought, cold and freezing. The most extensively studied function of flavonoids is their antioxidant activity although their importance as antioxidants in plants has been questioned. We therefore aim to study effects of flavonols on cellular stress tolerance that are independent of their antioxidant function. Here we investigate the effects of the glycosylated flavonols kaempferol-3-O-glucoside, kaempferol-7-O-glucoside, quercetin-3-O-glucoside and quercetin-3-O-rhamnoside on liposome stability after freezing and drying...
December 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27663949/bioactive-benzofuran-chalcanes-as-potential-nqo1-inducers-from-millettia-pulchra-benth-kurzvar-laxior-dunn-z-wei
#16
Wenli Wang, Ning Li, Jian Wang, Gang Chen, Renbin Huang, Weihong Zhao, Jiayuan Li, Yingying Si
Five chalcanes ((α'R)-2, α'-dimethoxy-furano-[4″, 5'': 3', 4'] chalcane, (α'R, βR)-2', α', β-trimethoxy-furano-[4″, 5'': 3', 4'] chalcane, (α'S, βR)-2', α', β-trimethoxy-furano-[4″, 5'': 3', 4'] chalcane, (α'R, βR)-2', β-dimethoxy-α'-hydroxyethoxy-furano-[4″, 5'': 3', 4'] chalcane, (α'S, βR)-2', β-dimethoxy-α'-hydroxyethoxy-furano-[4″, 5'': 3', 4'] chalcane) and a flavonoid glycoside (3', 7-dihydroxy-6-methoxy-4', 5'-methylenedioxyisoflavone 6-O-β-D- glucopyranoside), together with 15 known components, were isolated from the leaves of Millettia pulchra (Benth) Kurzvar-laxior (Dunn) Z...
November 2016: Phytochemistry
https://www.readbyqxmd.com/read/27604963/in-vitro-lipolytic-antioxidant-and-anti-inflammatory-activities-of-roasted-pistachio-kernel-and-skin-constituents
#17
Mary H Grace, Debora Esposito, Michael A Timmers, Jia Xiong, Gad Yousef, Slavko Komarnytsky, Mary Ann Lila
A comprehensive phytochemical analysis was conducted on pistachios to identify the differential contributions of skin and kernel phytochemicals to in vitro bioactivity. Qualitative and quantitative analyses of skin and kernel non-polar extracts (SNP and KNP, respectively) indicated that the major components are fatty acids (696.36 and 879.70 mg g(-1)), phytosterols (16.08 and 4.28 mg g(-1)), and γ-tocopherol (304.17 and 397.10 μg g(-1)). Analysis of the skin and kernel polar extracts (SP and KP, respectively) showed that skin accumulated higher levels of phenolic compounds, especially flavan-3-ols, compared to the kernel...
October 12, 2016: Food & Function
https://www.readbyqxmd.com/read/27589867/different-narrow-band-light-ranges-alter-plant-secondary-metabolism-and-plant-defense-response-to-aphids
#18
Ole Rechner, Susanne Neugart, Monika Schreiner, Sasa Wu, Hans-Michael Poehling
Light of different wavelengths affects various physiological processes in plants. Short-wavelength radiation (like UV) can activate defense pathways in plants and enhance the biosynthesis of secondary metabolites (such as flavonoids and glucosinolates) responsible for resistance against certain herbivorous insects. The intensity of light-induced, metabolite-based resistance is plant- and insect species-specific and depends on herbivore feeding guild and specialization. In this study, broccoli (Brassica oleracea var...
September 2, 2016: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/27589714/purification-of-flavonoids-from-chinese-bayberry-morella-rubra-sieb-et-zucc-fruit-extracts-and-%C3%AE-glucosidase-inhibitory-activities-of-different-fractionations
#19
Shuxia Yan, Xianan Zhang, Xin Wen, Qiang Lv, Changjie Xu, Chongde Sun, Xian Li
Chinese bayberry (Morella rubra Sieb. et Zucc.) fruit have a diverse flavonoid composition responsible for the various medicinal activities, including anti-diabetes. In the present study, efficient simultaneous purification of four flavonoid glycosides, i.e., cyanidin-3-O-glucoside (1), myricetin-3-O-rhamnoside (2), quercetin-3-O-galactoside (3), quercetin-3-O-rhamnoside (4), from Chinese bayberry pulp was established by the combination of solid phase extract (SPE) by C18 Sep-Pak(®) cartridge column chromatography and semi-preparative HPLC (Prep-HPLC), which was followed by HPLC and LC-MS identification...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27575326/qualitative-and-quantitative-phytochemical-characterization-of-myrothamnus-flabellifolia-welw
#20
Claudia Engelhardt, Frank Petereit, Matthias Lechtenberg, Ursula Liefländer-Wulf, Andreas Hensel
The upper aerial parts and leaf tips of Myrothamnus flabellifolia Welw. (Myrothamnaceae), a resurrection plant indigenous to southern Africa, are used in African traditional medicine for infections of the respiratory and urinary system as well as for inflammation of mucosa and skin. Within a phytochemical investigation of the herbal material from M. flabellifolia the flavonoid fraction was shown to contain quercetin 10 as well as the respective 3-O-β-d-galactosides, glucosides, -glucuronides and 3-O-α-l-rhamnosides of quercetin (6, 7, 8, 26) and kaempferol (1, 2, 3, 9)...
October 2016: Fitoterapia
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