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Quercetin glycoside

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https://www.readbyqxmd.com/read/29317330/comprehensive-evaluation-of-the-flavonol-anti-oxidants-alpha-glycosyl-isoquercitrin-and-isoquercitrin-for-genotoxic-potential
#1
Cheryl A Hobbs, Mihoko Koyanagi, Carol Swartz, Jeffrey Davis, Sawako Kasamoto, Robert Maronpot, Leslie Recio, Shim-Mo Hayashi
Quercetin and its glycosides possess potential benefits to human health. Several flavonols are available to consumers as dietary supplements, promoted as anti-oxidants; however, incorporation of natural quercetin glycosides into food and beverage products has been limited by poor miscibility in water. Enzymatic conjugation of multiple glucose moieties to isoquercitrin to produce alpha-glycosyl isoquercitrin (AGIQ) enhances solubility and bioavailability. AGIQ is used in Japan as a food additive and has been granted generally recognized as safe (GRAS) status...
January 6, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29300477/isolation-of-flavonoids-and-flavonoid-glycosides-from-myrsine-africana-and-their-inhibitory-activities-against-mushroom-tyrosinase
#2
Navneet Kishore, Danielle Twilley, Analike Blom van Staden, Praveen Verma, Bikram Singh, Giorgia Cardinali, Daniela Kovacs, Mauro Picardo, Vivek Kumar, Namrita Lall
Bioassay-guided fractionation of the methanol extract of the shoots of Myrsine africana led to the isolation of the new compound myricetin 3-O-(2″,4″-di-O-acetyl)-α-l-rhamnopyranoside (9) and 11 known compounds. The known compounds quercetin 3-O-(3″,4″-di-O-acetyl)-α-l-rhamnopyranoside (8), rutin (10), quercetin 3-O-α-l-rhamnopyranoside (11), and myricetin 3-O-α-l-rhamnopyranoside (12) are reported for the first time from the methanol extract of the shoots of M. africana. Compounds 10 and 12 showed significant inhibition of tyrosinase with 50% inhibition (IC50 values) of the enzyme at 0...
January 4, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29243430/-study-on-screening-antitumor-active-fractions-and-chemical-components-in-active-fractions-from-root-of-anaycclus-pyrethrum
#3
Jie Dong, Jiang Yuan, Jia-Li Wang, Rui-Fang Ji, Qing-Hua Quan, Xiao-Yu Guo, Jian Gao, Yong-Gang Liu
Components that systematic separated from the root of Anaycclus pyrethrum were identified, in order to lay a foundation for future study of the root of A. pyrethrum. The CCK-8 assay showed that dichloromethane fraction exhibited the highest degree of cytotoxicity than others. Ten monomeric components were obtained from dichloromethane fraction and ethyl acetate fraction extracted from the root of A. pyrethrum, including 7 N-alkylamides, one coumarin and two flavonoid glycosides. They were identified as tetradeca-2E,4E,8E-trienoic acid 4-hydroxyphenylethylamide(1), deca-2E,4E-dienoicacid isobutylamide(2), undeca-2E,4E-diene-8,10-diynoic acid phenylethylamide(3), tetradeca-2E,4E-dienoic acid 4-hydroxyphenylethylamide(4), tetradeca-2E,4E-diene-8,10-diynoic acid isobutylamide(5), deca-2E,4E- dienoic acid 4-hydroxyphenylethylamide(6), dodeca-2E,4E-dienoic acid 4-hydroxy -phenyl-ethylamide(7), isoscopoletin(8), quercetin-7-O-β-D-glucopyranoside(9), isorhamnetin-7-O-β-D-glucopyranoside(10)...
October 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29234420/mmp-inhibitory-effects-of-flavonoid-glycosides-from-edible-medicinal-halophyte-limonium-tetragonum
#4
Min Joo Bae, Fatih Karadeniz, Jung Hwan Oh, Ga Hyun Yu, Mi-Soon Jang, Ki-Ho Nam, Youngwan Seo, Chang-Suk Kong
Limonium tetragonum has been well-known for its antioxidative properties as a halophyte. This study investigated the antimetastasis effect of solvent-partitioned L. tetragonum extracts (LTEs) and isolated compounds on HT1080 mouse melanoma cell model with a focus on matrix metalloproteinase (MMP) activity and TIMP and MAPK pathways. Upregulation and stimulation of MMPs result in elevated degradation of extracellular matrix which is part of several complications such as metastasis, cirrhosis, and arthritis. The anti-MMP capacity of LTEs was confirmed by their MMP-inhibitory effects, regulation of MMP and TIMP expression, and suppression of MAPK pathway...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29229419/capillary-electrophoresis-as-a-fast-and-efficient-alternative-for-the-analysis-of-urceola-rosea-leaf-extracts
#5
Vera Gufler, Hieu Nguyen Ngoc, Hermann Stuppner, Markus Ganzera
Urceola rosea, a plant whose leaves are used as food and for medical purposes, is a climbing liana found in many south-east Asian countries. Main polar compounds are flavonoids (kaempferol and quercetin glycosides) and phenolic acids. As an alternative to the established HPLC method their analysis by capillary electrophoresis is described for the first time. It was possible in <8min with a 25mM sodium tetraborate decahydrate solution with pH8.5, at a capillary temperature of 40°C and an applied voltage of 25kV...
December 8, 2017: Fitoterapia
https://www.readbyqxmd.com/read/29214446/ugt79b31-is-responsible-for-the-final-modification-step-of-pollen-specific-flavonoid-biosynthesis-in-petunia-hybrida
#6
Eva Knoch, Satoko Sugawara, Tetsuya Mori, Ryo Nakabayashi, Kazuki Saito, Keiko Yonekura-Sakakibara
UGT79B31 encodes flavonol 3- O -glycoside: 2″- O -glucosyltransferase, an enzyme responsible for the terminal modification of pollen-specific flavonols in Petunia hybrida. Flavonoids are known to be involved in pollen fertility in petunia (P. hybrida) and maize (Zea mays). As a first step toward elucidating the role of flavonoids in pollen, we have identified a glycosyltransferase that is responsible for the terminal modification of petunia pollen-specific flavonoids. An in silico search of the petunia transcriptome database revealed four candidate UDP-glycosyltransferase (UGT) genes...
December 6, 2017: Planta
https://www.readbyqxmd.com/read/29200710/identification-of-hepatoprotective-constituents-in-limonium-tetragonum-and-development-of-simultaneous-analysis-method-using-high-performance-liquid-chromatography
#7
Jae Sun Lee, Yun Na Kim, Na-Hyun Kim, Jeong-Doo Heo, Min Hye Yang, Jung-Rae Rho, Eun Ju Jeong
Background: Limonium tetragonum, a naturally salt-tolerant halophyte, has been studied recently and is of much interest to researchers due to its potent antioxidant and hepatoprotective activities. Objective: In the present study, we attempted to elucidate bioactive compounds from ethyl acetate (EtOAc) soluble fraction of L. tetragonum extract. Furthermore, the simultaneous analysis method of bioactive EtOAc fraction of L. tetragonum has been developed using high-performance liquid chromatography (HPLC)...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29190278/can-narrow-bandwidth-light-from-uv-a-to-green-alter-secondary-plant-metabolism-and-increase-brassica-plant-defenses-against-aphids
#8
Ole Rechner, Susanne Neugart, Monika Schreiner, Sasa Wu, Hans-Michael Poehling
Light of different wavelengths is essential for plant growth and development. Short-wavelength radiation such as UV can shift the composition of flavonoids, glucosinolates, and other plant metabolites responsible for enhanced defense against certain herbivorous insects. The intensity of light-induced, metabolite-based resistance is plant- and insect species-specific and depends on herbivore feeding guild and specialization. The increasing use of light-emitting diodes (LEDs) in horticultural plant production systems in protected environments enables the creation of tailor-made light scenarios for improved plant cultivation and induced defense against herbivorous insects...
2017: PloS One
https://www.readbyqxmd.com/read/29156563/wnt-inhibitory-activity-of-malus-pumila-miller-cv-annurca-and-malus-domestica-cv-limoncella-apple-extracts-on-human-colon-rectal-cells-carrying-familial-adenomatous-polyposis-mutations
#9
Gennaro Riccio, Maria Maisto, Sara Bottone, Nadia Badolati, Giovanni Battista Rossi, Gian Carlo Tenore, Mariano Stornaiuolo, Ettore Novellino
Inhibitors of the Wingless-related Integration site (WNT)/β-catenin pathway have recently been under consideration as potential chemopreventive agents against Familial Adenomatous Polyposis (FAP). This autosomal-dominant syndrome is caused by germline mutations in the gene coding for the protein APC and leads to hyperactivation of the WNT/β-catenin signaling pathway, uncontrolled intestinal cell proliferation and formation of adenocarcinomas. The aim of the present work was to: (i) test, on in vitro cultures of cells carrying FAP mutations and on ex vivo biopsies of FAP patients, the WNT inhibitory activity of extracts from two common southern Italian apples, Malus pumila Miller cv...
November 18, 2017: Nutrients
https://www.readbyqxmd.com/read/29149062/polyphenolics-from-albizia-harveyi-exhibit-antioxidant-activities-and-counteract-oxidative-damage-and-ultra-structural-changes-of-cryopreserved-bull-semen
#10
Mansour Sobeh, Soha A Hassan, Mohamed A El Raey, Wael A Khalil, Mahmoud A E Hassan, Michael Wink
Albizia harveyi is a tropical deciduous tree, found across South and Eastern Africa and widely used in traditional medicine. The leaf extract ameliorated the damaging effects of the frozen-thawing process in cryopreserved bull semen. In a dose-dependent pattern, sperm motility, viability, and membrane integrity were improved compared to the untreated control. Furthermore, the extract increased the percentage of viable sperm cells and reduced the percentages of early apoptotic and apoptotic sperm cells as well as the damage in sperm ultra-structure...
November 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29142421/extract-of-bauhinia-vahlii-shows-antihyperglycemic-activity-reverses-oxidative-stress-and-protects-against-liver-damage-in-streptozotocin-induced-diabetic-rats
#11
Ahmed H Elbanna, Mohammed M Nooh, Engy A Mahrous, Amal E Khaleel, Taha S Elalfy
Background: Several studies have affirmed the effectiveness of some Bauhinia plants as antihyperglycemic agents. Objective: We investigated the possible effect of Bauhinia vahlii leaves extract in reducing hyperglycemia and reversing signs of organ damage associated with diabetes in streptozotocin (STZ) rat model. Materials and Methods: Both polar fraction of the B. vahlii leaves (defatted ethanolic extract [DEE]) and nonpolar fraction (n-hexane extract) were evaluated in vitro for α-glucosidase inhibition and 2,2-diphenyl-1-picrylhydrazyl radical scavenging potential...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29142403/flavonoidal-constituents-antioxidant-antimicrobial-and-cytotoxic-activities-of-dipterygium-glaucum-grown-in-kingdom-of-saudi-arabia
#12
Usama Shaheen, Nagwa Abdelkader Shoeib, Abeer Temraz, Mohamed I S Abdelhady
Background: Dipterygium glaucum Decne. herb is one of the common traditional plants with multiple medicinal uses. Objective: To isolate the major constituents and to investigate the antioxidant, antimicrobial, and cytotoxic activities of this herb. Materials and Methods: Methanolic extract of D. glaucum herb was fractionated using n-hexane, dichloromethane, and n-butanol. Butanol fraction was chromatographed using column chromatography and preparative thin layer chromatography to isolate the major constituents...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29142401/phytochemical-compositions-and-in-vitro-assessments-of-antioxidant-and-antidiabetic-potentials-of-fractions-from-ehretia-cymosa-thonn
#13
Akintayo Ogundajo, Anofi Tom Ashafa
Background: Ehretia cymosa Thonn. is a popular medicinal plant used in different parts of West Africa for the treatment of various ailments including diabetes mellitus. Objective: The current study investigates bioactive constituents and in vitro antioxidant and antidiabetic potentials of fractions from extract of E. cymosa. Materials and Methods: Phytochemical investigation and antioxidant assays were carried out using standard procedures...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29141065/use-of-isoquercetin-in-the-treatment-of-prurigo-nodularis
#14
Christine M Pennesi, John Neely, Ames G Marks, S Alison Basak
<p>Atopic dermatitis and prurigo nodularis result from complex interactions between the skin, the immune system, and the external environment. The pruritus associated with these conditions greatly impacts patients' quality of life and lacks uniformly effective treatment. A 57-year-old patient presented with severe atopic dermatitis and subsequent prurigo nodularis refractory to numerous standard therapies. The supplement isoquercetin was initiated and he noted significant, sustained reduction in his pruritus after only four weeks...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29106971/interaction-of-a-quercetin-derivative-lensoside-a%C3%AE-with-liposomal-membranes
#15
Bozena Pawlikowska-Pawlega, Justyna Kapral, Antoni Gawron, Anna Stochmal, Jerzy Zuchowski, Lukasz Pecio, Rafal Luchowski, Wojciech Grudzinski, Wieslaw I Gruszecki
Lensoside Aβ, representing the flavonol glycosides, is a compound isolated from the aerial parts of edible lentil (Lens culinaris) cultivar Tina. This substance arouse interest because so far there is very little data about secondary metabolites isolated from the leaves and stems of this plant. Additionally, bioactive potential of flavonoids is directly coupled with the membranes as a primary target of their physiological and pharmacological activity. The aim of this study was to investigate the effect of lensoside Aβ on lipid membranes...
October 26, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29098825/-water-soluble-constituents-from-the-twigs-of-litsea-cubeba
#16
Ling-Yan Wang, Yu-Hong Qu, Yan-Cheng Li, Yu-Zhuo Wu, Rui Li, Qing-Lan Guo, Su-Juan Wang, Ya-Nan Wang, Yong-Chun Yang, Sheng Lin
Twenty five known aromatic glycosides (1-25) and three known sesquiterpene glycosides (26-28) have been isolated from the twigs of Litsea cubeba by using various chromatographic techniques. Their structures were identified by spectroscopic data analysis (MS, IR, 1D and 2D NMR) as (7S,8R)-dehydrodiconiferyl alcohol 4,9'-di-O-β-D-glucopyranoside(1),(7S,8R)-5-methoxydihydrodehydrodiconiferyl alcohol 4-O-β-D-glucopyranoside(2), (7S,8R)-urolignoside(3), (7R,8S)-dihydrodehydrodiconiferyl alcohol 4-O-β-D-glucopyranoside(4), saposide B(5), lanicepside A(6), matairesinol-4-O-β-D-glucopyranoside (7), tyraxjaponoside B(8), (+)-lyoniresinol-9'-O-β-D-glucopyranoside (9), alaschanisoside A (10), syringin (11), psoralenoside (12), isopsoralenoside (13), scopolin(14), 2,6-dimethoxy-4-hydroxyphenol-1-O-β-D-glucopyranoside (15), 3-hydroxy-4,5-dimethoxyphenyl-β-D-glucopyranoside (16), 2-(3,4-dihydroxyphenyl)ethyl-β-D-glucopyrnoside (17), 2-(4-dihydroxyphenyl)ethyl-β-D-glucopyranoside (18), (+)-catechin-7-O-β-D-glucopyranoside (19), 3'-O-methylepicatechin-7-O-β-D-glucopyranoside (20), kaempferitrin (21), quercetin-3-O-α-L-rhamnopyranside (22), kaempferol-3-O-β-D-glucopyranoside (23), kaempferol 3-O-β-D-glucopyranosyl(1→2)-O-β-D-galactopyr anoside-7-O-α-L-rhamnopyranoside (24), quercetin 3-O-α-L-rhamnopyranosyl(1→6)-O-β-D-glucopyranosyl(1→3)-O-α-L-rhamnopyranosyl(1→2)-O-β-D-glucopyranoside (25), staphylionoside D(26), vomifoliol 9-O-β-D-glucopyranoside (27), dihydrovomifoliol-O-β-D-glucopyranoside (28)...
July 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29075874/the-ripening-disorder-berry-shrivel-affects-anthocyanin-biosynthesis-and-sugar-metabolism-in-zweigelt-grape-berries
#17
Michaela Griesser, Sara Crespo Martinez, Markus W Eitle, Benedikt Warth, Christelle M Andre, Rainer Schuhmacher, Astrid Forneck
Timescale analyses suggest the berry shrivel (BS) disorder is induced before veraison with strong effects on anthocyanin biosynthesis, and minor effects on sugar transport and metabolism. Berry shrivel (BS)-affected grapes have low sugar contents, high acidity, less anthocyanins and flaccid berries. To date no pathogenic causes are known, and studies to elucidate the molecular basis leading to symptom induction and development are limited. Here we present a study on pre-symptomatic as well as symptomatic BS berries to characterize early metabolic changes, with focus on anthocyanin biosynthesis and sugars metabolism...
October 26, 2017: Planta
https://www.readbyqxmd.com/read/29045617/purification-of-four-flavonoid-glycosides-from-lotus-nelumbo-nucifera-gaertn-plumule-by-macroporous-resin-combined-with-hsccc
#18
Lei Wu, Wei Xiong, Ju-Wu Hu, Zhen Gu, Jian-Guo Xu, Chuan-Ling Si, Young-Soo Bae, Gang Xu
High-speed counter-current chromatography (HSCCC) combined with macroporous resin (MR) column was successfully applied to the isolation and purification of four flavonoid glycosides from the medicinal herb Lotus plumule (LP). A polar two-phase solvent system composed of ethyl acetate-n-butanol-water (1:2:3, v/v/v) was selected by high-performance liquid chromatography (HPLC) and run on a preparative scale where the lower aqueous phase was used as the mobile phase with a head-to-tail elution mode. Quercetin-3-O-β-D-glucopyranoside (15 mg), isorhamnetin-3-O-β-D-glucopyranoside (13 mg), apigenin 6-C-β-D-glucopyranosyl-8-C-α-L-arabinopyranoside (18 mg) and apigenin 6,8-di-C-β-D-glucopyranoside (48 mg) were obtained in a one-step HSCCC separation from 240 mg of the sample...
October 17, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/29035528/role-of-flavonols-and-proanthocyanidins-in-the-sensory-quality-of-sea-buckthorn-hippopha%C3%A3-rhamnoides-l-berries
#19
Xueying Ma, Wei Yang, Oskar Laaksonen, Merja Nylander, Heikki Kallio, Baoru Yang
Sensory profile, flavonols, proanthocyanidins, sugars, and organic acids were investigated in purees of six sea buckthorn (Hippophaë rhamnoides) cultivars. The sensory profiles of the purees were dominated by intense sourness followed by astringency and bitterness due to the high content of malic acid. Malic acid and isorhamnetin glycosides, especially isorhamnetin-3-O-sophoroside-7-O-rhamnoside, had close association with the astringent attributes in the different purees, whereas some of the known astringent compounds such as proanthocyanidin dimers and trimers or quercetin glycosides, had less impact...
November 1, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29023372/parp-inhibition-by-flavonoids-induced-selective-cell-killing-to-brca2-deficient-cells
#20
Cathy Su, Alexis H Haskins, Chisato Omata, Yasushi Aizawa, Takamitsu A Kato
High consumption of dietary flavonoids might contribute to a reduction of cancer risks. Quercetin and its glycosides have PARP inhibitory effects and can induce selective cytotoxicity in BRCA2-deficient cells by synthetic lethality. We hypothesized that common flavonoids in diet naringenin, hesperetin and their glycosides have a similar structure to quercetin, which might have comparable PARP inhibitory effects, and can induce selective cytotoxicity in BRCA2-deficient cells. We utilized Chinese hamster V79 wild type, V-C8 BRCA2-deficient and its gene-complemented cells...
October 12, 2017: Pharmaceuticals
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