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Quercetin

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https://www.readbyqxmd.com/read/29456979/quercetin-prevents-body-weight-loss-due-to-the-using-of-superparamagnetic-iron-oxide-nanoparticles-in-rat
#1
Rezvan Enteshari Najafabadi, Nasrin Kazemipour, Abolghasem Esmaeili, Siamak Beheshti, Saeed Nazifi
Background: Superparamagnetic iron oxide nanoparticles (SPION) have been largely considered for numerous applications in biomedicine such as magnetic resonance imaging, hyperthermia, cell tracking, anticancer treatment, and targeted delivery of drugs or genes. However, they may have side effects such body weight loss. Quercetin (QT), a strong antioxidant and free radical scavenger and a natural flavonoid, has a wide range of biological and therapeutic effects. In this study, the effect of QT on prevention of weight loss due to the using of SPION has been investigated...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29455095/establishment-of-pancreatic-microenvironment-model-of-er-stress-quercetin-attenuates-%C3%AE-cell-apoptosis-by-invoking-nitric-oxide-cgmp-signaling-in-endothelial-cells
#2
Natarajan Suganya, Krishna Priya Mani, Dornadula Sireesh, Palanisamy Rajaguru, Mariappanadar Vairamani, Thiruppathi Suresh, Takayoshi Suzuki, Suvro Chatterjee, Kunka Mohanram Ramkumar
The involvement of endoplasmic reticulum (ER) stress in endothelial dysfunction and diabetes-associated complications has been well documented. Inhibition of ER stress represents a promising therapeutic strategy to attenuate endothelial dysfunction in diabetes. Recent attention has focused on the development of small molecule inhibitors of ER stress to maintain endothelial homeostasis in diabetes. Here we have developed a reliable, robust co-culture system that allows a study on the endothelial cells and pancreatic β-cells crosstalk under ER stress and validated using a known ER stress modulator, quercetin...
January 3, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29453263/enzyme-activities-of-two-recombinant-heme-including-peroxidases-tv-dyp1-and-tv-vp2-identified-from-the-secretome-of-trametes-versicolor
#3
Sawsan Amara, Thomas Perrot, David Navarro, Aurélie Deroy, Amine Benkhelfallah, Amani Chalak, Marianne Daou, Didier Chevret, Craig B Faulds, Jean Guy Berrin, Mélanie Morel-Rouhier, Eric Gelhaye, Eric Record
Trametes versicolor is a wood inhabiting Agaricomycete known for its ability to cause strong white rot decay on hardwood and for its high tolerance toward phenolic compounds. The goal of the present work was to give insights on the molecular biology and biochemistry of heme-including class-II and dye-decolorizing peroxidases secreted from this fungus. Proteomic analysis of the secretome of T. versicolor BRFM1218 grown on oak wood revealed a set of 200 secreted proteins among which were a dye-decolorizing peroxidase Tv DyP1 and a versatile peroxidase Tv VP2...
February 16, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29450118/elite-hairy-roots-of-raphanus-sativus-l-as-a-source-of-antioxidants-and-flavonoids
#4
Muthusamy Balasubramanian, Murugesan Anbumegala, Ramasamy Surendran, Muthukrishnan Arun, Girija Shanmugam
An efficient protocol for hairy root induction in radish was established by optimizing several parameters that affect the efficiency of Agrobacterium rhizogenes -mediated transformations. Explants wounded using sterile hypodermic needle, infected with Agrobacterium suspension (0.6 OD 600 ) for 10 min and co-cultivated in 1/2 MS medium containing acetosyringone (100 µM) for 2 days displayed maximum percentage of hairy root induction using MTCC 2364 (77.6%) and MTCC 532 (67.6%). On further experiments with MTCC 2364 initiated hairy roots, maximum biomass accumulation (fresh weight = 9...
February 2018: 3 Biotech
https://www.readbyqxmd.com/read/29449621/polygonum-aviculare-l-extract-and-quercetin-attenuate-contraction-in-airway-smooth-muscle
#5
Xi Luo, Lu Xue, Hao Xu, Qing-Yang Zhao, Qian Wang, Yu-Shan She, Dun-An Zang, Jinhua Shen, Yong-Bo Peng, Ping Zhao, Meng-Fei Yu, Weiwei Chen, Li-Qun Ma, Shu Chen, Shanshan Chen, Xiangning Fu, Sheng Hu, Xiaowei Nie, Chenyou Shen, Chunbin Zou, Gangjian Qin, Jiapei Dai, Guangju Ji, Yunchao Su, Shen Hu, Jingyu Chen, Qing-Hua Liu
Because of the serious side effects of the currently used bronchodilators, new compounds with similar functions must be developed. We screened several herbs and found that Polygonum aviculare L. contains ingredients that inhibit the precontraction of mouse and human airway smooth muscle (ASM). High K+ -induced precontraction in ASM was completely inhibited by nifedipine, a selective blocker of L-type voltage-dependent Ca2+ channels (LVDCCs). However, nifedipine only partially reduced the precontraction induced by acetylcholine chloride (ACH)...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29446655/micrornas-as-molecular-targets-of-quercetin-and-its-derivatives-underlying-their-biological-effects-a-preclinical-strategy
#6
Dan Wang, Dongxiao Sun-Waterhouse, Feng Li, Li Xin, Dapeng Li
Quercetin is a well-known flavonoid naturally occurring in most of the plant foods and is often found in the human diet. It can act as a potent antioxidant and anti-inflammatory agent, and plays significant roles in the prevention of various chronic diseases. Recent findings revealed that quercetin could affect metabolic traits by regulating certain transcription factors or key proteins involved in cellular signal pathways and influencing the expression of functional genes along with related regulatory pathway(s), and that microRNAs (miRNAs) circulate in body fluids and are involved in post-transcriptional gene silencing and regulation of gene expression in various biological processes including development, proliferation, metabolism and inflammation...
February 15, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29446420/newly-synthesized-quercetin-derivatives-as-corrosion-inhibitors-for-mild-steel-in-1-m-hcl-combined-experimental-and-theoretical-investigation
#7
Dipankar Sukul, Aparesh Pal, Sourav Kr Saha, Sanjoy Satpati, Utpal Adhikari, Priyabrata Banerjee
To evaluate the corrosion inhibition efficacy of the derivatives of naturally available organics, mono and di-4-((2-hydroxyethyl)piperazin-1-yl)methyl derivatives of quercetin, a flavonoid, have been synthesized. Their potential as anti-corrosive agents is assessed for mild steel in 1 M HCl employing the weight-loss technique as well as electrochemical methods. Comparing the rate of corrosion in uninhibited and inhibited solutions as a function of temperature, the thermodynamic parameters of adsorption of these derivatives on mild steel surfaces and the kinetic parameters of the corrosion process are evaluated...
February 15, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29444501/quercetin-therapy-for-selected-patients-with-pim1-kinase-positive-chronic-lymphocytic-leukemia-small-lymphocytic-lymphoma-a-pilot-study
#8
Beverly W Baron, Michael J Thirman, Mihai C Giurcanu, Joseph M Baron
We reported that PIM1 kinase is expressed in the lymphocytes of patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). Quercetin, a naturally occurring flavonoid, is a dietary supplement and inhibits many kinases, including PIM1, in vitro. Under an Institutional Review Board-approved protocol, we performed an open-label, single-arm pilot study to evaluate the antitumor activity of quercetin in patients with CLL/SLL. Q-ForceTM chews were administered orally, 500 mg twice daily, for 3 months...
February 14, 2018: Acta Haematologica
https://www.readbyqxmd.com/read/29442390/deciphering-the-biochemical-and-molecular-mechanism-underlying-the-in-vitro-and-in-vivo-chemotherapeutic-efficacy-of-ruthenium-quercetin-complex-in-colon-cancer
#9
Souvik Roy, Rituparna Das, Balaram Ghosh, Tania Chakraborty
Flavonoids are the most investigated phytochemicals due to their pharmacological and therapeutic activities. Their ability to chelate with metal ions has resulted in the emergence of a new category of molecules with a broader spectrum of pharmacological activities. In this study, the ruthenium quercetin complex has been synthesised and anticancer activity has been evaluated on a well-defined model of DMH followed by DSS induced rat colon cancer and on human colon cancer cell line HT-29. The characterizations accomplished through UV-visible, NMR, IR, Mass spectra and XRD techniques and antioxidant activity was assessed by DPPH, FRAP and ABTS methods...
February 14, 2018: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29442047/comprehensive-phytochemical-characterization-of-st-john-s-wort-hypericum-perforatum-l-oil-macerates-obtained-by-different-extraction-protocols-via-analytical-tools-applicable-in-routine-control
#10
M Heinrich, R Daniels, F C Stintzing, D R Kammerer
The aim of the present study was to investigate the impact of crucial process parameters, i.e. of light and temperature conditions, during the preparation of St. John's wort (SJW, Hypericum perforatum L.) Arachis oil macerates. Extracts were prepared according to a standardized protocol over a period of 28 days. For this purpose, flowering tops of H. perforatum were macerated with Arachis oil (drug extract ratio, DERnative 1:4) under different light and temperature conditions. Spectrophotometric measurements were carried out to quantitate naphthodianthrones and to characterize extract color in the CIE L*C*h° system...
March 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29438890/flavonoids-from-chinese-bayberry-leaves-induced-apoptosis-and-g1-cell-cycle-arrest-via-erk-pathway-in-ovarian-cancer-cells
#11
Yu Zhang, Shiguo Chen, Chaoyang Wei, Gary O Rankin, Xingqian Ye, Yi Charlie Chen
Ovarian cancer is one of the leading causes of death related to the female reproductive system in western countries. Adverse side effects and resistance to platinum based chemotherapy have become the major obstacles for ovarian cancer treatment. Natural products have gained great attention in cancer treatment in recent years. Chinese bayberry leaves flavonoids (BLF) containing rich content of myricitrin (myricetin 3-O-rhamnoside) and a part of quercetrin (quercetin 3-rhamnoside) inhibited the growth of an ovarian cancer cell line A2780/CP70...
January 31, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29438776/quercetin-ameliorates-hfd-induced-nafld-by-promoting-hepatic-vldl-assembly-and-lipophagy-via-the-ire1a-xbp1s-pathway
#12
Xinhong Zhu, Ting Xiong, Peiyi Liu, Xiaoping Guo, Lin Xiao, Feng Zhou, Yuhan Tang, Ping Yao
The consumption of a quercetin-rich diet has been well-established as a feasible method against non-alcoholic fatty liver disease (NAFLD); however, the molecular mechanisms underlying the progression of NAFLD and its intervention by quercetin remain largely obscure. Male Sprague-Dawley rats fed high-fat diet (HFD), and HepG2 cells stimulated with free fatty acid, were treated with quercetin and various pharmacological reagents to explore the effect of signaling pathways involved in endoplasmic reticulum stress on very low-density lipoprotein (VLDL) assembly and lipophagy...
February 10, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29438306/comparative-analysis-of-chemical-composition-antioxidant-activity-and-quantitative-characterization-of-some-phenolic-compounds-in-selected-herbs-and-spices-in-different-solvent-extraction-systems
#13
Shabnam Sepahpour, Jinap Selamat, Mohd Yazid Abdul Manap, Alfi Khatib, Ahmad Faizal Abdull Razis
This study evaluated the efficacy of various organic solvents (80% acetone, 80% ethanol, 80% methanol) and distilled water for extracting antioxidant phenolic compounds from turmeric, curry leaf, torch ginger and lemon grass extracts. They were analyzed regarding the total phenol and flavonoid contents, antioxidant activity and concentration of some phenolic compounds. Antioxidant activity was determined by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay and the ferric reducing antioxidant power (FRAP) assay...
February 13, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29436996/herbal-products-for-common-auto-inflammatory-disorders-novel-approaches
#14
Fawzi Mahomoodally, Shanoo Suroowan
Common auto-inflammatory disorders (CAIDs) induce considerable suffering over the world. A panoply of synthetic medications areis available for theirits management. Nonetheless, available drug classes are limited by adverse effects, low systemic absorption, and high costs. In addition, no cure exists for most CAIDs. Interestingly, herbal products present a tremendous potential for development as anti-inflammatory agents. In this endeavor, major scientific databases; Google Scholar, Pubmed, ScienceDirect, and Scopus were explored to highlight novel therapeutic approaches using herbal products for CAIDs prophylaxis, management, treatment, and prevention of relapse...
February 12, 2018: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/29435999/the-effect-of-greenhouse-covering-materials-on-phytochemical-composition-and-antioxidant-capacity-of-tomato-cultivars
#15
Latifeh Ahmadi, Xiuming Hao, Rong Tsao
BACKGROUND: The effect of light transmission (direct and diffuse) on the phenolic compounds of five tomato cultivars was investigated under controlled conditions in greenhouses covered with different covering materials. RESULTS: The type of covering materials and type of diffusion of light simultaneously affected the reducing power of cultivars. In the present study, a two-way analysis of variance showed statistically significant differences in total phenolic compound (TPC) for the different cultivars (P<0...
February 13, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29435775/quercetin-prevents-in-vivo-and-in-vitro-myocardial-hypertrophy-through-the-proteasome-gsk-3-pathway
#16
Kuixiang Chen, Mubarak Rekep, Wei Wei, Qian Wu, Qin Xue, Sujuan Li, Jiahui Tian, Quan Yi, Genshui Zhang, Guiping Zhang, Qing Xiao, Jiandong Luo, Yinghua Liu
PURPOSE: Quercetin, a flavonoid, has been reported to ameliorate cardiovascular diseases, such as cardiac hypertrophy. However, the mechanism is not completely understood. In this study, a mechanism related to proteasome-glycogen synthesis kinase 3 (GSK-3) was elucidated in rats and primary neonatal cardiomyocytes. METHODS: Rats were subjected to sham or constriction of abdominal aorta surgery groups and treated with or without quercetin for 8 weeks. Angiotensin II (Ang II)-induced primary cardiomyocytes were cultured with quercetin treatment or not for 48 h...
February 12, 2018: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/29435700/the-content-of-dietary-fibre-and-polyphenols-in-morphological-parts-of-buckwheat-fagopyrum-tataricum
#17
Krzysztof Dziedzic, Danuta Górecka, Artur Szwengiel, Hanna Sulewska, Ivan Kreft, Elżbieta Gujska, Jarosław Walkowiak
In this report, we presented the profile of polyphenolic substances in flowers, leaves, stalk and roots of Fagopyrum tataricum estimated by using RP-UHPLC-ESI-MS equipment (reversed-phase ultra-high-performance liquid chromatography electrospray ionisation mass spectrometry). The neutral detergent fibre, acid detergent fibre, acid detergent lignin, cellulose and hemicellulose were also determined. Flowers, leaves, stalk and roots showed varying levels of dietary fibre and polyphenols. The highest content of neutral and acid detergent fibre were found in the roots (63...
February 12, 2018: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/29435602/auto-fluorescence-of-a-silk-fibroin-based-scaffold-and-its-interference-with-fluorophores-in-labeled-cells
#18
Mehdi Amirikia, Seyed Mohammad Ali Shariatzadeh, Seyed Gholam Ali Jorsaraei, Malek Soleimani Mehranjani
Silk fibroin is increasingly emerging as an important biomaterial for tissue engineering applications. The ability to fluorescently image silk matrices under a microscope would be helpful in differentiating embedded labeled cells from background signal, critical for the study of silk-based engineered tissues. In this study, we fabricated a scaffold using freeze drying and confirmed its structure by X-ray diffraction and Fourier transform infrared spectroscopy. We then examined the fluorescence of the silk fibroin scaffold using confocal microscopy, both before and after cell seeding and fluorescent labeling...
February 12, 2018: European Biophysics Journal: EBJ
https://www.readbyqxmd.com/read/29434932/quercetin-reverses-the-doxorubicin-resistance-of-prostate-cancer-cells-by-downregulating-the-expression-of-c-met
#19
Yan Shu, Bo Xie, Zhen Liang, Jing Chen
Chemotherapy is an irreplaceable treatment for prostate cancer. However, the acquisition of chemoresistance is a common and critical problem that requires urgent solutions for the effective treatment of this disease. The aim of the present study was to determine whether the combination of quercetin with doxorubicin reversed the resistance of prostate cancer cells to doxorubicin-based therapy. A prostate cancer (PC)3 cell line (PC3/R) with acquired doxorubicin-resistance was established. A significant drug-resistance to doxorubicin and high activation of the phosphoinositide 3-kinase/protein kinase-B (PI3K/AKT) pathway in PC3/R cells, compared with normal PC3 cells, was demonstrated...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434473/trail-induced-apoptosis-in-trail-resistant-breast-carcinoma-through-quercetin-cotreatment
#20
Jasmine M Manouchehri, Katherine A Turner, Michael Kalafatis
Breast cancer is the most commonly diagnosed cancer in women. There is a continued interest for the development of more efficacious treatment regimens for breast carcinoma. Recombinant human tumor necrosis factor-related apoptosis-inducing ligand (rhTRAIL) shows potential as a potent anticancer therapeutic for the treatment of breast cancer, whereas displaying minimal toxicity to normal cells. However, the promise of rhTRAIL for the treatment of breast cancer is dismissed by the resistance to rhTRAIL-induced apoptosis exhibited by many breast cancers...
2018: Breast Cancer: Basic and Clinical Research
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