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Quercetin

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https://www.readbyqxmd.com/read/29040945/quercetin-protects-mouse-liver-against-triptolide-induced-hepatic-injury-by-restoring-th17-treg-balance-through-tim-3-and-tlr4-myd88-nf-%C3%AE%C2%BAb-pathway
#1
Cai-Bing Wei, Kun Tao, Rong Jiang, Lian-Di Zhou, Qi-Hui Zhang, Chun-Su Yuan
Triptolide (TP) is a diterpene triepoxide with various biological activities, but its clinical applications have been limited by potential hepatotoxicity, which can be attributed to T helper 17 (Th17)/T regulatory (Treg) cell imbalance. Quercetin (QE), a natural flavonoid, has been reported to have many benefits and medicinal properties, including hepatoprotective activity against TP-induced liver injury. However, the hepatoprotection mechanisms have not been clarified. The present study was designed to explore the protective effect and the mechanism of QE against TP-induced liver injury...
October 14, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29035884/protective-effects-of-pretreatment-with-quercetin-against-lipopolysaccharide-induced-apoptosis-and-the-inhibition-of-osteoblast-differentiation-via-the-mapk-and-wnt-%C3%AE-catenin-pathways-in-mc3t3-e1-cells
#2
Chun Guo, Rui-Juan Yang, Ke Jang, Xiao-Ling Zhou, Yu-Zhen Liu
BACKGROUND/AIMS: Quercetin, a flavonoid found in onions and other vegetables, has potential inhibitory effects on bone resorption in vivo and in vitro. In our previous study, we found that quercetin treatment reversed lipopolysaccharide (LPS)-induced inhibition of osteoblast differentiation through the mitogen-activated protein kinase (MAPK) pathway in MC3T3-E1 cells. In this study, we investigated the underlying mechanisms of pretreatment with quercetin on apoptosis and the inhibition of osteoblast differentiation in MC3T3-E1 cells induced by LPS...
October 16, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29035613/quercetin-induced-amp-activated-protein-kinase-activation-attenuates-vasoconstriction-through-lkb1-ampk-signaling-pathway
#3
Seul Gi Kim, Jae-Ryong Kim, Hyoung Chul Choi
The vascular tone plays an important role in blood pressure and flow. It is influenced by the contraction of vascular smooth muscle cells (VSMCs), which in turn is regulated by the balance between the myosin light chain kinase (MLCK) and the phosphorylated myosin light chain (p-MLC). Quercetin is a common flavonoid which is found in many fruits and red wine. Although quercetin has been widely reported to be involved in cell proliferation, migration, and apoptosis in VSMCs, it has not yet been demonstrated whether quercetin is related to vasocontraction, a function regulated by the AMP-activated protein kinase (AMPK) signaling pathway...
October 16, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29035528/role-of-flavonols-and-proanthocyanidins-in-the-sensory-quality-of-sea-buckthorn-hippopha%C3%A3-rhamnoides-l-berries
#4
Xueying Ma, Wei Yang, Oskar A Laaksonen, Merja Nylander, Heikki Kallio, Baoru Yang
Sensory profile, flavonols, proanthocyanidins, sugars, and fruit acids were investigated in purees of six sea buckthorn (Hippophaë rhamnoides) cultivars. The sensory profiles of the purees were dominated by intense sourness followed by astringency and bitterness, due to the high content of malic acid. Malic acid and isorhamnetin glycosides, especially isorhamnetin-3-O-sophoroside-7-O-rhamnoside, had close association with the astringent attributes in the different purees, whereas some of the known astringent compounds, such as proanthocyanidin dimers and trimers or quercetin glycosides, had less impact...
October 16, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29034200/promising-effect-of-rosa-damascena-extract-on-high-fat-diet-induced-nonalcoholic-fatty-liver
#5
Ida Davoodi, Roja Rahimi, Mohammad Abdollahi, Fatemeh Farzaei, Mohammad Hosein Farzaei, Zahra Memariani, Fariba Najafi
NAFLD is a chronic liver disease that affects a high proportion of the world's population which causes metabolic and hepatic damages. Rosa damascena Mill is traditionally used as a dietary supplement for liver disorders. This study was carried out to determine the beneficial effect of standardized extract of R. damascena on animal model of nonalcoholic fatty liver disease (NAFLD). NAFLD was induced by high-fat diet (HFD) in Wistar rats. HFD rats showed an increase (p < 0.05) in the plasma lipid levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and reduced the high-density lipoprotein (HDL) levels...
October 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29030990/novel-nanohydrogel-of-hyaluronic-acid-loaded-with-quercetin-alone-and-in-combination-with-temozolomide-as-new-therapeutic-tool-cd44-targeted-based-of-glioblastoma-multiforme
#6
M Barbarisi, R V Iaffaioli, E Armenia, L Schiavo, G De Sena, S Tafuto, A Barbarisi, V Quagliariello
Glioblastoma multiforme is the most common and aggressive primary brain cancer with only ∼3% of patients surviving more than 3 years from diagnosis. Several mechanisms are involved in drug and radiation resistance to anticancer treatments and among them one of the most important factors is the tumour microenvironment status, characterised by cancer cell hypersecretion of interleukins and cytokines. The aim of our research was the synthesis of a nanocarrier of quercetin combined with temozolomide, to enhance the specificity and efficacy of this anticancer drug commonly used in glioblastoma treatment...
October 14, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29029404/quercetin-induced-ros-production-triggers-mitochondrial-cell-death-of-human-embryonic-stem-cells
#7
So-Yeon Kim, Ho-Chang Jeong, Soon-Ki Hong, Mi-Ok Lee, Seung-Ju Cho, Hyuk-Jin Cha
Small molecules to selectively induce cell death of undifferentiated human pluripotent stem cells (hPSCs) have been developed with the aim of lowering the risk of teratoma formation during hPSC-based cell therapy. In this context, we have reported that Quercetin (QC) induces cell death selectively in hESCs via p53 mitochondrial localization. However, the detailed molecular mechanism by which hESCs undergo selective cell death induced by QC remains unclear. Herein, we demonstrate that mitochondrial reactive oxygen species (ROS), strongly induced by QC in human embryonic stem cells (hESCs) but not in human dermal fibroblasts (hDFs), were responsible for QC-mediated hESC's cell death...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29026320/quercetin-inhibits-epithelial-mesenchymal-transition-decreases-invasiveness-and-metastasis-and-reverses-il-6-induced-epithelial-mesenchymal-transition-expression-of-mmp-by-inhibiting-stat3-signaling-in-pancreatic-cancer-cells
#8
Dinglai Yu, Tingting Ye, Yukai Xiang, Zhehao Shi, Jie Zhang, Bin Lou, Fan Zhang, Bicheng Chen, Mengtao Zhou
Quercetin, a flavone, is multifaceted, having anti-oxidative, anti-inflammatory, and anticancer properties. In the present study, we explored the effects of quercetin on the epithelial-mesenchymal transition (EMT) and invasion of pancreatic cancer cells and the underlying mechanisms. We noted that quercetin exerted pronounced inhibitory effects in PANC-1 and PATU-8988 cells. Moreover, quercetin inhibited EMT and decreased the secretion of matrix metalloproteinase (MMP). Meanwhile, we determined the activity of STAT3 after quercetin treatment...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29023716/production-of-cornstarch-granules-enriched-with-quercetin-liposomes-by-aggregation-of-particulate-binary-mixtures-using-high-shear-process
#9
Taíse Toniazzo, Helena Galeskas, Gustavo C Dacanal, Samantha C Pinho
Liposomes are colloidal structures capable of encapsulating, protecting, and releasing hydrophobic bioctives, as flavonoids. Quercetin is a flavonoid with high antioxidant activity that provides benefits to health. The wet-agglomeration processes in high-shear equipment are useful to produce granules from binary mixtures, obtaining a powder with homogeneous composition and without segregation or elutriation of fine particles. In this study, the binary mixtures containing microparticles of native cornstarch and nanoparticles of quercetin liposomes were aggregated in high-shear batches, using maltodextrin solution as binder agent...
October 12, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29023372/parp-inhibition-by-flavonoids-induced-selective-cell-killing-to-brca2-deficient-cells
#10
Cathy Su, Alexis H Haskins, Chisato Omata, Yasushi Aizawa, Takamitsu A Kato
High consumption of dietary flavonoids might contribute to a reduction of cancer risks. Quercetin and its glycosides have PARP inhibitory effects and can induce selective cytotoxicity in BRCA2-deficient cells by synthetic lethality. We hypothesized that common flavonoids in diet naringenin, hesperetin and their glycosides have a similar structure to quercetin, which might have comparable PARP inhibitory effects, and can induce selective cytotoxicity in BRCA2-deficient cells. We utilized Chinese hamster V79 wild type, V-C8 BRCA2-deficient and its gene-complemented cells...
October 12, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/29023013/anti-proliferation-and-apoptosis-induction-of-aqueous-leaf-extract-of-carica-papaya-l-on-human-breast-cancer-cells-mcf-7
#11
Fatma Zuhrotun Nisa, Mary Astuti, Agnes Murdiati, Sofia Mubarika Haryana
BACKGROUND AND OBJECTIVE: Breast cancer is the most frequently diagnosed cancer in women. Chemotherapy is the main method of breast cancer treatment but there are side effects. Carica papaya leaves is vegetable foods consumed by most people of Indonesia have potential as anticancer. The aim of this study was to investigate anti-proliferative and apoptotic induced effect of aqueous papaya leaves extracts on human breast cancer cell lines MCF-7. MATERIALS AND METHODS: Inhibitory on cell proliferation was measured by MTT assay while apoptosis induction was measured using Annexin V...
2017: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/29022361/interactions-of-quercetin-with-receptor-tyrosine-kinases-associated-with-human-lung-carcinoma
#12
Bincy Baby, Priya Antony, Ranjit Vijayan
Lung cancer is a deadly form of cancer with high morbidity and mortality rates. Deregulated receptor tyrosine kinases (RTKs) are frequently associated with the formation and development of lung carcinoma. Quercetin is a major dietary flavonoid that has been shown to induce cell growth inhibition and apoptosis in human lung cancer cell lines. In the current study, four major overexpressed RTKs - EGFR, FGFR1, IGF1R and c-Met - involved in human lung cancer were investigated. Molecular docking was employed to identify the binding orientation and inhibitory potential of quercetin in these RTKs...
October 12, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29019668/application-of-targeted-metabolomics-to-investigate-optimum-growing-conditions-to-enhance-bioactive-content-of-strawberry
#13
Ikram Akhatou, Ana Sayago, Raúl González-Domínguez, Angeles Fernández-Recamales
A simple, sensitive and rapid assay based on liquid chromatography coupled to tandem mass spectrometry was designed for simultaneous quantitation of secondary metabolites in order to investigate the influence of variety and agronomic conditions on the biosynthesis of bioactive compounds in strawberry. For this purpose, strawberries belonging to three varieties with different sensitivity to environmental conditions ('Camarosa', 'Festival', 'Palomar') were grown in soilless system under multiple agronomic conditions (electrical conductivity, substrate type and coverage)...
October 11, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29019431/synthesis-and-spectroscopic-characterization-study-of-new-palladium-complexes-containing-bioactive-o-o-chelated-ligands-evaluation-of-the-dna-protein-bsa-interaction-in-vitro-antitumoral-activity-and-molecular-docking
#14
Kazem Karami, Zohreh Mehri Lighvan, Hossein Farrokhpour, Maryam Dehdashti Jahromi, Amir Abbas Momtazi-Borojeni
[Pd{(C,N)-C6H4CH2NH(Et) (Qu)] (2) and [Pd{(C,N)-C6H4CH2NH(Et) (Nar)] (3) (Qu=Quercetin, Nar=Naringin) mononuclear palladium (II) complexes have been synthesized and characterized using elemental analysis, IR and electronic spectroscopy. The interaction of the prepared complexes with calf thymus DNA (CT DNA) and bovine serum albumin (BSA), monitored by UV-visible and fluorescence titrations, respectively, have been carried out to better understand the mode of their action under biological conditions. Intercalative binding mode between the complexes and DNA is suggested by the binding constant (Kb) values of 2...
October 11, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29017485/bidens-pilosa-ethylene-acetate-extract-can-protect-against-l-name-induced-hypertension-on-rats
#15
Danielle Claude Bilanda, Paul Désiré D Dzeufiet, Léontine Kouakep, Bibi Farouck O Aboubakar, Léonard Tedong, Pierre Kamtchouing, Théophile Dimo
BACKGROUND: Essential hypertension is mainly caused by endothelial dysfunction which results from nitric oxide (NO) deficiency. The present study was design to evaluate the protective effect of Bidens pilosa ethylene acetate extract (Bp) on L-NAME induced hypertension and oxidative stress in rats. METHODS: Male Wistar rats were used to induce hypertension by the administration of L-NAME (a non-pecific nitric oxide inhibitor) (50 mg/kg/day). The others groups were receiving concomitantly L-NAME plus Bp extract (75 and 150 mg/kg/day) or losartan (25 mg/kg/day)...
October 10, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29017109/development-of-a-lc-ms-ms-method-to-investigate-the-interference-of-pharmacokinetics-of-the-main-constituents-in-saxifraga-stolonifera-involvement-of-drug-metabolism-enzymes
#16
Yuan Wang, Qing Li, Yue Dai, Ronghua Pan, Yufeng Xia
A specific and sensitive LC-MS/MS method was established for the simultaneous determination of bergenin, protocatechuic acid and gallic acid, the main active constituents of Saxifraga stolonifera (L.) Meerb. herb, in rat plasma. After fully validated, the method was applied to the comparative pharmacokinetic studies of the three compounds orally administered alone and in combination in the S. stolonifera extract, respectively. The results showed that the pharmacokinetic parameters, including Cmax, Tmax, AUC, CLz/F, MRT0-∞, were significantly different for both bergenin and protocatechuic acid in the extract as compared to the corresponding compounds administered alone...
September 29, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28993661/metabolic-signatures-in-response-to-abscisic-acid-aba-treatment-in-brassica-napus-guard-cells-revealed-by-metabolomics
#17
Mengmeng Zhu, Sarah M Assmann
Drought can severely damage crops, resulting in major yield losses. During drought, vascular land plants conserve water via stomatal closure. Each stomate is bordered by a pair of guard cells that shrink in response to drought and the associated hormone abscisic acid (ABA). The activation of complex intracellular signaling networks underlies these responses. Therefore, analysis of guard cell metabolites is fundamental for elucidation of guard cell signaling pathways. Brassica napus is an important oilseed crop for human consumption and biodiesel production...
October 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28991533/an-uhplc-ms-ms-method-for-simultaneous-determination-of-quercetin-3-o-rutinoside-kaempferol-3-o-rutinoside-isorhamnetin-3-o-rutinoside-bilobalide-and-ligustrazine-in-rat-plasma-and-its-application-to-pharmacokinetic-study-of-xingxiong-injection
#18
Li-Li Dou, Li Duan, Long Guo, Le-Le Liu, Yu-Dong Zhang, Ping Li, E-Hu Liu
The present study was designed to develop and validate a rapid, sensitive, and reliable ultra-high performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS) method for the simultaneous determination of five major active constituents in the traditional Chinese medicinal preparation Xingxiong injection (XXI) in rat plasma, including quercetin 3-O-rutinoside (QCR), kaempferol 3-O-rutinoside (KFR), isorhamnetin 3-O-rutinoside (ISR), bilobalide (BB), and ligustrazine (LGT). The plasma samples were pretreated by protein precipitation with acetonitrile...
September 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28990837/quercetin-nanoparticles-alter-pharmacokinetics-of-bromocriptine-reflecting-its-enhanced-inhibitory-action-on-liver-and-intestinal-cyp-3a-enzymes-in-rats
#19
Suresh Palle, Prasad Neerati
1. Quercetin is a dietary flavonoid has extremely low water solubility and found to possess CYP3A inhibitory activity. The purpose of the present study was to evaluate the effect of quercetin and quercetin nanoparticles (NQC) on the pharmacokinetics of bromocriptine (BRO) in rats. 2. NQC prepared by antisolvent precipitation method and characterized by SEM and dissolution test. The following methods were used in this study i.e. in vitro liver and intestinal CYP3A microsomal activity and in vitro non-everted sac method...
October 9, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/28990815/anti-inflammatory-effect-of-ethanolic-extract-of-spine-skin-and-rind-of-jack-fruit-peel-a-comparative-study
#20
M Meera, A Ruckmani, R Saravanan, R Lakshmipathy Prabhu
The present study was conducted to identify the chemical constituents and evaluate the anti-inflammatory activity of crude ethanolic extracts of spine, skin and rind of jack fruit (Artocarpus heterophyllus) peel. Polyphenol and flavonoid contents were assessed using Folin's Ciocalteu reagent and aluminium chloride methods which revealed 316, 355 and 382 mg tannic acid equivalent/g of polyphenol and 96.7, 131.6 and 164.6 mg quercetin equivalent/g of flavonoid in spine, skin and rind, respectively. Anti-inflammatory activity of all three extracts was comparable to diclofenac in vitro and in vivo studies...
October 9, 2017: Natural Product Research
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