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Quercetin

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https://www.readbyqxmd.com/read/29224051/quercetin-protects-yeast-saccharomyces-cerevisiae-pep4-mutant-from-oxidative-and-apoptotic-stress-and-extends-chronological-lifespan
#1
Phaniendra Alugoju, Sudharshan Setra Janardhanshetty, Subasri Subaramanian, Latha Periyasamy, Madhu Dyavaiah
The yeast Saccharomyces cerevisiae PEP4 gene encodes vacuolar endopeptidase proteinase A (Pep4p), which is a homolog of the human CTSD gene that encodes cathepsin D. Mutation of CTSD gene in human resulted in a number of neurodegenerative diseases. In this study, we have shown that yeast pep4 mutant cells are highly sensitive to oxidative and apoptotic stress induced by hydrogen peroxide and acetic acid, respectively. pep4∆ cells also showed accumulation of reactive oxygen species (ROS), apoptotic markers, and reduced chronological lifespan...
December 9, 2017: Current Microbiology
https://www.readbyqxmd.com/read/29222242/treatment-of-inherited-bone-marrow-failure-syndromes-beyond-transplantation
#2
REVIEW
Rodrigo T Calado, Diego V Clé
Despite significant progress in transplantation by the addition of alternative hematopoietic stem cell sources, many patients with inherited bone marrow failure syndromes are still not eligible for a transplant. In addition, the availability of sequencing panels has significantly improved diagnosis by identifying cryptic inherited cases. Androgens are the main nontransplant therapy for bone marrow failure in dyskeratosis congenita and Fanconi anemia, reaching responses in up to 80% of cases. Danazol and oxymetholone are more commonly used, but virilization and liver toxicity are major adverse events...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29220817/infrared-spectroscopy-of-flavones-and-flavonols-reexamination-of-the-hydroxyl-and-carbonyl-vibrations-in-relation-to-the-interactions-of-flavonoids-with-membrane-lipids
#3
Goran Baranović, Suzana Šegota
Detailed vibrational assignments for twelve flavonoids (seven flavones (flavone, 3- and 5-hydroxyflavone, chrysin, apigenin, fisetin and luteolin) and five flavonols (galangin, kaempferol, quercetin, morin and myricetin)) have been made based on own and reported experimental data and calculations at the B3LYP/6-31+G(d,p) level of theory. All the molecules are treated in a uniform way by using the same set of redundancy-free set of internal coordinates. A generalized harmonic mode mixing is used to corroborate the vibrational characteristics of this important class of molecules...
December 2, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29220803/a-single-cell-analysis-platform-for-electrochemiluminescent-detection-of-platelets-adhesion-to-endothelial-cells-based-on-au-dl-zncqds-nanoprobes
#4
Dongping Long, Yunfei Shang, Youyi Qiu, Bin Zhou, Peihui Yang
A novel single-cell analysis platform (SCA) was developed for the investigation of platelets adhesion to single human umbilical vein endothelial cell (HUVEC) via using the adhesion molecule (E-selectin) on the damaged HUVEC as the marker site, and integrating electrochemiluminescence (ECL) with the ultrasensitive Au@DL-ZnCQDs nanoprobes. The Au@DL-ZnCQDs nanocomposite, a kind of double layer zinc-coadsorbed carbon quantum dot (ZnCQDs) core-shell nanoprobe, was firstly constructed by using gold nanoparticles (AuNPs) as the core to load with ZnCQDs and then the citrate-modified silver nanoparticles (AgNPs) as the bridge to link AuNPs-ZnCQDs with ZnCQDs to form the core-shell with double layer ZnCQDs (DL-ZnCQDs) nanoprobe, revealed a 10-fold signal amplification...
November 22, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29217339/standardization-chemical-profiling-in%C3%A2-vitro-cytotoxic-effects-in%C3%A2-vivo-anti-carcinogenic-potential-and-biosafety-profile-of-indian-propolis
#5
Harshad Kapare, Sathiyanarayanan Lohidasan, Arulmozhi Sinnathambi, Kakasaheb Mahadik
BACKGROUND: Propolis from apiculture is known for wide range of medicinal properties owing to its vast chemical constituents including polyphenols, flavonoids and anticancer agent Caffeic acid phenethyl ester (CAPE). OBJECTIVES: The objective of the study was to extract and standardize Indian propolis (IP) with respect to selected markers by newly developed High performance liquid chromatography (HPLC) method, to evaluate in vitro and in vivo anticancer activity and biosafety of Indian propolis...
December 4, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/29216586/non-ionic-detergent-triton-x-114-based-vortex-synchronized-matrix-solid-phase-dispersion-method-for-the-simultaneous-determination-of-six-compounds-with-various-polarities-from-forsythiae-fructus-by-ultra-high-performance-liquid-chromatography
#6
Kunze Du, Jin Li, Fei Tian, Yan-Xu Chang
A simple nonionic detergent - based vortex- synchronized matrix solid-phase dispersion (ND-VSMSPD) method was developed to extract bioactive compounds in Forsythiae Fructus coupled with ultra high-performance liquid chromatography (UHPLC). Nonionic detergent Triton 114 was firstly used as a green elution reagent in vortex- synchronized MSPD procedure. The optimum parameters were investigated to attain the best results, including Florisil as sorbent, 2mL 10% (v/v) nonionic detergent Triton X-114 as the elution reagent, 1:1 of sample/sorbent ratio, grinding for 3min, and whirling for 2min...
December 4, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29215110/quercetin-inhibits-renal-cyst-growth-in-vitro-and-via-parenteral-injection-in-a-polycystic-kidney-disease-mouse-model
#7
Yangyang Zhu, Tian Teng, Hu Wang, Hao Guo, Lei Du, Baoxue Yang, Xiaoxing Yin, Ying Sun
Autosomal dominant polycystic kidney disease (ADPKD) is a common monogenic disease characterized by massive enlargement of fluid-filled cysts in the kidney. There is an urgent need to develop effective ADPKD therapies. We used an in vitro Madin-Darby canine kidney (MDCK) cyst model and a murine embryonic kidney cyst model to evaluate whether quercetin inhibits cyst development. We then used a polycystic kidney disease (PKD) mouse model to further determine the in vivo effects of quercetin (100 mg per kg body weight twice per day) on PKD mice via subcutaneous injections...
December 7, 2017: Food & Function
https://www.readbyqxmd.com/read/29214656/screening-active-components-of-modified-xiaoyao-powder-as-nrf2-agonists
#8
Yujie Yang, Yanran Wang, Ting Wang, Xuehua Jiang, Ling Wang
Nuclear factor (erythroid-derived 2)-like 2 (NRF2) regulates antioxidant enzymes and phase II detoxifying enzymes, such as NAD(P)H: quinone oxidoreductase 1 (NQO1). Modified Xiaoyao powder (MXP) is most frequently used in the prevention and treatment of breast cancer in China. This study aimed to screen active components of MXP for antioxidant stress and chemoprevention, which depend on NRF2-NQO1 signalling pathway. A total of 25 monomeric compounds contained in MXP were screened using an antioxidant response element-luciferase reporter...
December 7, 2017: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/29214446/ugt79b31-is-responsible-for-the-final-modification-step-of-pollen-specific-flavonoid-biosynthesis-in-petunia-hybrida
#9
Eva Knoch, Satoko Sugawara, Tetsuya Mori, Ryo Nakabayashi, Kazuki Saito, Keiko Yonekura-Sakakibara
UGT79B31 encodes flavonol 3- O -glycoside: 2″- O -glucosyltransferase, an enzyme responsible for the terminal modification of pollen-specific flavonols in Petunia hybrida. Flavonoids are known to be involved in pollen fertility in petunia (P. hybrida) and maize (Zea mays). As a first step toward elucidating the role of flavonoids in pollen, we have identified a glycosyltransferase that is responsible for the terminal modification of petunia pollen-specific flavonoids. An in silico search of the petunia transcriptome database revealed four candidate UDP-glycosyltransferase (UGT) genes...
December 6, 2017: Planta
https://www.readbyqxmd.com/read/29209454/kimchi-attenuates-fatty-streak-formation-in-the-aorta-of-low-density-lipoprotein-receptor-knockout-mice-via-inhibition-of-endoplasmic-reticulum-stress-and-apoptosis
#10
Minji Woo, Mijeong Kim, Jeong Sook Noh, Chan Hum Park, Yeong Ok Song
BACKGROUND/OBJECTIVES: Endoplasmic reticulum (ER) stress is positively associated with atherosclerosis via elevating macrophage cell death and plaque formation, in which oxidative stress plays a pivotal role. Antioxidative, lipid-lowering, and anti-atherogenic effects of kimchi, a Korean fermented vegetable, have been established, wherein capsaicin, ascorbic acid, quercetin, 3-(4'-hydroxyl-3',5'-dimethoxyphenyl)propionic acid, and lactic acids were identified. In this study, mechanisms of action of kimchi methanol extracts (KME) on fatty streak formation via suppression of ER stress and apoptosis in aorta were examined in low-density lipoprotein receptor knockout mice...
December 2017: Nutrition Research and Practice
https://www.readbyqxmd.com/read/29209349/regulation-of-fig-ficus-carica-l-fruit-color-metabolomic-and-transcriptomic-analyses-of-the-flavonoid-biosynthetic-pathway
#11
Ziran Wang, Yuanyuan Cui, Alexander Vainstein, Shangwu Chen, Huiqin Ma
Combined metabolomic and transcriptomic analyses were carried out with fig cultivar Green Peel and its color mutant "Purple Peel." Five and twenty-two metabolites were identified as having significantly different contents between fruit peels of the two cultivars at young and mature stages, respectively. Cyanidin O-malonylhexoside demonstrated a 3,992-fold increase in the mature purple peel, the first identification of a major cyanidin in fig fruit; cyanidin 3-O-glucoside, cyanidin O-malonylhexoside O-hexoside and cyanidin-3,5-O-diglucoside were upregulated 100-fold, revealing the anthocyanins underlying the purple mutation...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29208278/mixed-ligand-copper-ii-complex-of-quercetin-regulate-osteogenesis-and-angiogenesis
#12
Selvaraj Vimalraj, Subramaniyam Rajalakshmi, Desingh Raj Preeth, Sivasubramanian Vinoth Kumar, Thirumalai Deepak, Venkatraman Gopinath, Kadarkarai Murugan, Suvro Chatterjee
Copper(II) complex of quercetin Cu+Q, mixed ligand complexes, quercetin-Cu(II)-phenanthroline [Cu+Q(PHt)] and quercetin-Cu(II)-neocuproine [Cu+Q(Neo)] have been synthesized and characterized. From the FT-IR spectroscopic studies, it was evident that C-ring of quercetin is involved in the metal chelation in all the three copper complexes. C-ring chelation was further proven by UV-Visible spectra and the presence of Cu(II) from EPR spectroscopic investigations. These complexes were found to have osteogenic and angiogenic properties, observed through in vitro osteoblast differentiation and chick embryo angiogenesis assay...
February 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29207575/synthesis-of-novel-nitrogen-containing-heterocycle-bromophenols-and-their-interaction-with-keap1-protein-by-molecular-docking
#13
Xiu E Feng, Qin Jin Wang, Jie Gao, Shu Rong Ban, Qing Shan Li
We previously reported 5,2'-dibromo-2,4',5'-trihydroxydiphenylmethanoe (LM49), a bromophenol analogue that shows strong protection from oxidative stress injury owing to its superior anti-inflammatory, antioxidant, and anti-apoptotic properties. A series of novel nitrogen-containing heterocycle bromophenols were herein synthesized by introducing substituted piperidine, piperazine, and imidazole to modify 2-position of the lead compound LM49. By further evaluating their cytoprotective activity against H₂O₂ induced injury in EA...
December 4, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29207194/quercetin-synergistically-reactivates-human-immunodeficiency-virus-type-1-latency-by-activating-nuclear-factor%C3%A2-%C3%AE%C2%BAb
#14
Xinyi Yang, Xiaoli Zhu, Haiyan Ji, Junxiao Deng, Panpan Lu, Zhengtao Jiang, Xian Li, Yibo Wang, Chuqiao Wang, Jingya Zhao, Yanan Wang, Yangcheng Zhong, He Yang, Huanzhang Zhu
Highly active antiretroviral therapy (HAART) is very effective in suppressing human immunodeficiency virus type 1 (HIV‑1) replication. However, the treatment is required to be administered for the remainder of an individual's lifetime due to latent HIV‑1 reservoirs. The 'shock‑and‑kill' strategy, which involves using agents to reactivate latent HIV‑1 and subsequently killing latently infected cells in the presence of HAART, was recently proposed. Unfortunately, no agents have currently demonstrated an ability to reactivate latent HIV‑1 in vivo in the absence of toxicity...
November 29, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29207037/anti%C3%A2-inflammatory-effect-of-quercetin-and-galangin-in-lps%C3%A2-stimulated-raw264-7-macrophages-and-dncb%C3%A2-induced-atopic-dermatitis-animal-models
#15
Hae Nim Lee, Seong Ah Shin, Gang Sik Choo, Hyeong Jin Kim, Young Seok Park, Byeong Soo Kim, Sang Ki Kim, Sung Dae Cho, Jeong Seok Nam, Chang Sun Choi, Jeong Hwan Che, Byung Kwon Park, Ji Youn Jung
Flavonols are compounds that have been shown to possess potent anti‑inflammatory effects in cellular and animal models of inflammation. In the present study, the anti‑inflammatory effects and mechanisms of two natural flavonols, quercetin and galangin, in lipopolysaccharide (LPS)‑stimulated RAW264.7 macrophages were investigated. It was identified that quercetin and galangin markedly reduced the production of nitric oxide (NO), inducible NO synthase and interleukin‑6, and the nuclear translocation of nuclear factor‑κB (NF‑κB)...
November 29, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29207020/quercetin-inhibits-okadaic-acid-induced-tau-protein-hyperphosphorylation-through-the-ca2-%C3%A2-calpain%C3%A2-p25%C3%A2-cdk5-pathway-in-ht22-cells
#16
Xiu-Yin Shen, Tao Luo, Sheng Li, Ou-Yang Ting, Feng He, Jie Xu, Hua-Qiao Wang
Alzheimer's disease (AD) is a common neurodegenerative disorder characterized by aberrant tau protein hyperphosphorylation, which eventually leads to the formation of neurofibrillary tangles. Hyperphosphorylated tau protein is considered as a vital factor in the development of AD and is highly associated with cognitive impairment. Therefore, it is recognized to be a potential therapeutic target. Quercetin (QUE) is a naturally occurring flavonoid compound. In the present study, the inhibitory effect of QUE on okadaic acid (OA)-induced tau protein hyperphosphorylation in HT22 cells was explored...
November 22, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29205806/neuroprotection-by-quercetin-via-mitochondrial-function-adaptation-in-traumatic-brain-injury-pgc-1%C3%AE-pathway-as-a-potential-mechanism
#17
Xiang Li, Handong Wang, Guodao Wen, Liwen Li, Yongyue Gao, Zong Zhuang, Mengliang Zhou, Lei Mao, Youwu Fan
The aim of this study was to investigate the neuroprotective effects of quercetin in mouse models of traumatic brain injury (TBI) and the potential role of the PGC-1α pathway in putative neuroprotection. Wild-type mice were randomly assigned to four groups: the sham group, the TBI group, the TBI+vehicle group and the TBI+quercetin group. Quercetin, a dietary flavonoid used as a food supplement, significantly reduced TBI-induced neuronal apoptosis and ameliorated mitochondrial lesions. It significantly accelerated the translocation of PGC-1α protein from the cytoplasm to the nucleus...
December 4, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29203747/-effect-of-antioxidants-on-human-primary-and-metastatic-colon-cancer-cells-at-hypoxia-and-normoxia
#18
Magdalena Mielczarek-Puta, Alicja Chrzanowska, Dagmara Otto-Ślusarczyk, Wojciech Graboń, Anna Barańczyk-Kuźma
THE AIM: Evaluation of some antioxidants on human colon cancer cells viability and proliferation at various oxygen levels. MATERIAL AND METHODS: Human primary (SW480) and metastatic (SW620) colon cancer cells were cultured at hypoxia (1% oxygen), tissues (10% oxygen) and atmospheric (21% oxygen) normoxia with quercetin, epigallocatechin gallate, lipoic acid, hydroxycitric acid, their mixture, and without studied compounds (control). Antioxidants were used at physiological concentrations...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29201361/quercetin-prevents-spinal-motor-neuron-degeneration-induced-by-chronic-excitotoxic-stimulus-by-a-sirtuin-1-dependent-mechanism
#19
Rafael Lazo-Gomez, Ricardo Tapia
Background: Excitotoxicity is a mechanism of foremost importance in the selective motor neuron degeneration characteristic of motor neuron disorders. Effective therapeutic strategies are an unmet need for these disorders. Polyphenols, such as quercetin and resveratrol, are plant-derived compounds that activate sirtuins (SIRTs) and have shown promising results in some models of neuronal death, although their effects have been scarcely tested in models of motor neuron degeneration. Methods: In this work we investigated the effects of quercetin and resveratrol in an in vivo model of excitotoxic motor neuron death induced by the chronic infusion of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) into the rat spinal cord tissue...
2017: Translational Neurodegeneration
https://www.readbyqxmd.com/read/29200716/antioxidant-and-inhibitory-effects-of-saponin-extracts-from-dianthus-basuticus-burtt-davy-on-key-enzymes-implicated-in-type-2-diabetes-in-vitro
#20
Mikhail Olugbemiro Nafiu, Anofi Omotayo Tom Ashafa
Context: Dianthus basuticus is a plant of South African origin with various acclaimed pharmaceutical potentials. Aims: This study explored the antioxidant and antidiabetic activities of saponin extract from D. basuticus in vitro. Materials and Methods: Antioxidant activity of saponin was evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and nitric oxide (*NO)-free radical scavenging activity while antidiabetic potentials were measured by the α-amylase and α-glucosidase inhibitory activities of the saponin extract...
October 2017: Pharmacognosy Magazine
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