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Quercetin

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https://www.readbyqxmd.com/read/28087355/generation-of-quercetin-cellulose-acetate-phthalate-systems-for-delivery-by-supercritical-antisolvent-process
#1
I García-Casas, A Montes, C Pereyra, E J Martínez de la Ossa
Supercritical antisolvent process (SAS) has been used to precipitate microparticles of quercetin, a plant pigment found in many foods and used for medical treatments, pharmaceutical and cosmetic industries, together with nanoparticles of cellulose acetate phthalate (CAP), a polymer quite frequently used in drug delivery. Previously, precipitation of nanoparticles of CAP by the same process was studied at different conditions of pressure, temperature, CO2and solution flow rates, nozzle diameter and initial concentration of the solution...
January 10, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28079005/dendritic-cells-modulate-iron-homeostasis-and-inflammatory-abilities-following-quercetin-exposure
#2
Vanessa Galleggiante, Stefania De Santis, Elisabetta Cavalcanti, Aurelia Scarano, Maria De Benedictis, Grazia Serino, Maria Lucia Caruso, Mauro Mastronardi, Aldo Pinto, Pietro Campiglia, Dale Kunde, Angelo Santino, Marcello Chieppa
BACKGROUND: Fruit and vegetables are rich in plant polyphenols, whose consumption is encouraged in healthy dietary regimes due to their antioxidants and anti-inflammatory effects. These organic molecules exhibit numerous properties including phylochelation; the ability to create complex with metal ions. Among polyphenols, we focused our attention to quercetin that previously demonstrated its ability to reduce dendritic cells (DCs) inflammatory cytokine secretion and antigen presentation following LPS exposure...
January 12, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28078783/new-propolis-type-from-northeast-brazil-chemical-composition-antioxidant-activity-and-botanical-origin
#3
Joselena M Ferreira, Caroline C Fernandes-Silva, Antonio Salatino, Giuseppina Negri, Dejair Message
BACKGROUND: Propolis is a bee product with wide diversity of biological activity. It has complex composition, which is dependent on its botanical source. The present work aimed at determining the chemical profile, antioxidant activity and botanical origin of two samples of a propolis type from two locations of the state of Rio Grande do Norte (RN, northeast Brazil). RESULTS: The standard chemical characteristics of the RN propolis are similar or superior to the internationally marketed Brazilian green propolis...
January 11, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28076833/7-o-geranylquercetin-induces-apoptosis-in-gastric-cancer-cells-via-ros-mapk-mediated-mitochondrial-signaling-pathway-activation
#4
Yanyan Zhu, Yameng Jiang, Lei Shi, Linying Du, Xiaodong Xu, Enxia Wang, Yong Sun, Xin Guo, Boyang Zou, Huaxin Wang, Changyuan Wang, Lidan Sun, Yuhong Zhen
7-O-Geranylquercetin (GQ) is a novel O-alkylated derivate of quercetin. In this study, we evaluated its apoptosis induction effects in human gastric cancer cell lines SGC-7901 and MGC-803 and explored the potential molecular mechanisms. The results demonstrated that GQ lowered viability of SGC-7901 and MGC-803 cells in a dose- and time-dependent manner without apparent cytotoxicity to human gastric epithelial cell line GES-1. GQ could induce apoptosis in SGC-7901 and MGC-803cells, and arrest the gastric cancer cells at G2/M phase...
January 8, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28073678/natural-potential-neuroinflammatory-inhibitors-from-alhagi-sparsifolia-shap
#5
Di Zhou, Hongyan Wei, Zhe Jiang, Xuezheng Li, Kun Jiao, Xiaoguang Jia, Yue Hou, Ning Li
Neuroinflammation is a key contributor to neuronal damage in neurodegenerative diseases. In our previous work on natural effective neuroinflammatory inhibitors, Alhagi sparsifolia Shap. (Leguminosae), a folk medicine widely distributed in Xinjiang, attracted our attention because of its significant anti-neuroinflammatory effect. Therefore, further investigation of the bioactive material basis was carried out. As a result, 33 major components were characterized and identified by chromatographic and spectral methods, respectively...
December 30, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28071026/antiradical-capacity-and-polyphenol-composition-of-asparagus-spears-varieties-cultivated-under-different-sunlight-conditions
#6
Bartosz Kulczyński, Joanna Kobus-Cisowska, Dominik Kmiecik, Anna Gramza-Michałowska, Dorota Golczak, Józef Korczak
BACKGROUND: Asparagus officinalis has a high nutritional value. Asparagus is rich in a number of bioactive compounds, mainly flavonoids (quercetin), glutathione, vitamin C, vitamin E, fructans (inulin and fructooligosaccharides) and phytosterols (b-sitosterol). These compounds may play an important role in human health. The purpose of this study was to examine the antioxidant potential and polyphenol composition of white, pale-colored and green asparagus spears of different cultivars...
July 2016: Acta Scientiarum Polonorum. Technologia Alimentaria
https://www.readbyqxmd.com/read/28070878/effects-of-caffeic-acid-and-quercetin-on-in-vitro-permeability-metabolism-and-in-vivo-pharmacokinetics-of-melatonin-in-rats-potential-for-herb-drug-interaction
#7
Snehasis Jana, Himanshu Rastogi
BACKGROUND AND OBJECTIVES: Melatonin is a popular dietary supplement and also considered as pharmaceutical product for sleep disorders. Caffeic acid and quercetin are widely distributed in leafy vegetables, fruits, tea extract, and both are used as natural antioxidant. There is an immense concern for health researchers to study the herb/food-drug interactions of melatonin. It is mainly metabolized by CYP1A2 in human so that herbs/foods containing cytochrome P450 (CYP) inhibitors can affect pharmacokinetics of melatonin...
January 9, 2017: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/28069457/quercetin-prevents-chronic-unpredictable-stress-induced-behavioral-dysfunction-in-mice-by-alleviating-hippocampal-oxidative-and-inflammatory-stress
#8
Vineet Mehta, Arun Parashar, Malairaman Udayabanu
It is now evident that chronic stress is associated with anxiety, depression and cognitive dysfunction and very few studies have focused on identifying possible methods to prevent these stress-induced disorders. Previously, we identified abundance of quercetin in Urtica dioica extract, which efficiently attenuated stress related complications. Therefore, current study was designed to investigate the effect of quercetin on chronic unpredicted stress (CUS) induced behavioral dysfunction, oxidative stress and neuroinflammation in the mouse hippocampus...
January 7, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28068840/effect-of-meteorological-parameters-and-regions-on-accumulation-pattern-of-phenolic-compounds-in-different-mulberry-cultivars-grown-in-china
#9
Jiufang Yang, Xiaoxu Zhang, Qing Jin, Liwei Gu, Xuanjun Liu, Jingming Li, Yuanying Ni
The compositions of phenolic compounds in 10 cultivars of two mulberry species (Morus atropurpurea Roxb. and Morus alba Linn.) grown in four regions of China were analysed using HPLC-TOF-MS. Results showed that a total of 27 phenolic compounds were identified in these mulberry cultivars. The Taiwan cultivar from the Jiangsu region showed the highest concentration of hydroxycinnamic acids, quercetin derivatives, and anthocyanins. Multivariate statistical analysis revealed that six mulberry cultivars grown in the region of Jiangsu, Ningxia, and Guangdong were differentiated regarding their species feature and regional characteristics...
January 9, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28068633/polyphenol-rich-ethanolic-extract-from-boerhavia-diffusa-l-mitigates-angiotensin-ii-induced-cardiac-hypertrophy-and-fibrosis-in-rats
#10
Prathapan A, Mathews V Varghese, Abhilash S, Salin Raj P, Anil K Mathew, Anupama Nair, R Harikumaran Nair, Raghu K G
Boerhavia diffusa is a renowned edible medicinal plant extensively used against different ailments including heart diseases in the traditional system of medicine in several countries. The present study aims to evaluate the therapeutic efficacy of ethanolic extract of Boerhavia diffusa (BDE) on cardiac hypertrophy and fibrosis induced by angiotensin II (Ang II) in male wistar rats and to identify the active components present in it. A substantial increase of hypertrophy markers such as cardiac mass index, concentration of ANP and BNP, cardiac injury markers like CK-MB, LDH and SGOT, has been observed in hypertrophied groups whereas BDE treatment attenuated these changes when compared to hypertrophied rats...
January 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28067579/hot-melt-extrusion-microencapsulation-of-quercetin-for-taste-masking
#11
Chia Miang Khor, Wai Kiong Ng, Parijat Kanaujia, Kok Ping Chan, Yuancai Dong
Besides its poor dissolution rate, the bitterness of quercetin also poses a challenge for further development. Using carnauba wax, shellac or zein as the shell-forming excipient, this work aimed to microencapsulate quercetin by hot-melt extrusion for taste-masking. In comparison with non-encapsulated quercetin, the microencapsulated powders exhibited significantly reduced dissolution in the simulated salivary pH 6.8 medium indicative of their potentially good taste-masking efficiency in the order of zein > carnauba wax > shellac...
January 9, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28066105/antifertility-activity-of-thevetia-peruviana-pers-k-schum-leaf-in-female-sprague-dawley-rat
#12
Jhuma Samanta, Snehendu Bhattacharya, Avtar C Rana
OBJECTIVES: Thevetia peruviana (Pers.) K. Schum. (Apocynaceae) is known to possess cardioactive glycoside such as thevetin A, thevetin B, neriifolin, peruvoside, thevetoxin, and ruvoside. Traditionally, T. peruviana leaves are used as abortifacient. The aim of the present study is to evaluate antifertility potential of T. peruviana leaves. SUBJECTS AND METHODS: Cardiac glycoside freed leaves of T. peruviana were extracted with methanol using maceration method. The dried cardiac glycoside-free methanolic extract of T...
November 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28065794/adjuvant-quercetin-therapy-for-combined-treatment-of-epilepsy-and-comorbid-depression
#13
Tanveer Singh, Taranjot Kaur, Rajesh Kumar Goel
Epilepsy is one of the major neurological disorders frequently associated with psychiatric disorders such as depression. The predisposition of tryptophan metabolism towards kynurenine pathway has been reported as one of the plausible reasons for association of depression in epilepsy. Hence, this study was envisaged to evaluate the dose dependent inhibition of indoleamine 2,3-dioxygenase (IDO) enzyme employing quercetin (screened employing in vitro method) with levetiracetam for combined management of epilepsy and comorbid depression...
January 5, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28063518/role-of-nutraceutical-sirt1-modulators-in-ampk-and-mtor-pathway-evidence-of-a-synergistic-effect
#14
Luca Giovannini, Sara Bianchi
OBJECTIVE: The aim of this study was to evaluate the effect of different natural substances on SIRT1 expression and on AMPK and mTOR phosphorylation. Moreover, we investigated the presence of a synergistic effect between the substances. METHODS: Human cervical carcinoma cells were seeded in 12-well plates, then incubated with the nine tested substances (resveratrol, quercetin, berberine, catechin, tyrosol, ferulic acid, niclosamide, curcumin, and malvidin) at different concentrations and left in incubation for 3, 6, and 24 h...
February 2017: Nutrition
https://www.readbyqxmd.com/read/28061888/antibacterial-activities-of-the-methanol-extract-fractions-and-compounds-from-elaeophorbia-drupifera-thonn-stapf-euphorbiaceae
#15
Igor K Voukeng, Blaise K Nganou, Louis P Sandjo, Ilhami Celik, Veronique P Beng, Pierre Tane, Victor Kuete
BACKGROUND: Elaeophorbia drupifera (Thonn.) Stapf. (Euphorbiaceae) is used in Cameroonian folk medicine to treat several ailments including bacterial-related diseases such as skin infections. In this study, the methanol extract from the leaves (EDL), fractions (EDLa-d), sub-fractions EDLc1-7 and EDLc31-35 as well as isolated compounds were tested for their antimicrobial activities against a panel of Gram-negative and Gram-positive bacteria including multidrug resistant (MDR) phenotypes...
January 7, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28058739/comparative-study-of-the-binding-of-3-flavonoids-to-the-fat-mass-and-obesity-associated-protein-by-spectroscopy-and-molecular-modeling
#16
Lijiao Zhang, Ting Ren, Zechun Wang, Ruiyong Wang, Junbiao Chang
This study aims to investigate the interaction between 3 flavonoids (quercetin, apigenin, and naringenin) and fat mass and obesity-associated protein by fluorescence, ultraviolet-visible absorption spectroscopy, and molecular modeling. Results indicate that the intrinsic fluorescence of fat mass and obesity-associated protein can be quenched by the 3 flavonoids through a static quenching procedure. Thermodynamic analysis and molecular modeling results suggest that hydrophobic interaction and hydrogen bond forces play the major roles in the binding process...
January 6, 2017: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/28056553/quercetin-and-the-ocular-surface-what-we-know-and-where-we-are-going
#17
Tina B McKay, Dimitrios Karamichos
Flavonoids are a class of plant and fungus secondary metabolites that serve functional roles in protecting against UV-induced oxidative stress, mediating auxin signaling, and promoting microbial defense. Flavonoids are extremely abundant in nature where their potent antioxidant capacity and very low toxicity makes them highly attractive as potential therapeutic agents. In terms of clinical applications, neither the Food and Drug Administration (FDA) nor the European Food Safety Authority (EFSA) has approved any health claims or drugs related to the use of flavonoids for therapeutic purposes...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28052646/ameliorative-potentials-of-quercetin-against-lead-induced-hematological-and-testicular-alterations-in-albino-rats
#18
Mohammed A. Al-Omair, Azza Sedky, Awatef Ali, Hany Elsawy
Lead is one of the oldest environmental and occupational toxins. Health hazards from increased lead exposure as a result of industrial and environmental pollution are recognized. The aim of the present study was to investigate the protective effects of quercetin as a model of an antioxidant drug against the toxic effects of lead acetate on the blood and the testis of rats. The lead concentrations were determined in blood and the testis. Testosterone (T), luteinizing hormone (LH) and follicle stimulating hormone (FSH) were assessed in serum...
28, 2017: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/28050761/role-of-the-polycarboxylic-compounds-in-the-response-of-silene-vulgaris-to-chromium
#19
Ana E Pradas Del Real, Jose Manuel Silvan, Sonia de Pascual-Teresa, Ana Guerrero, Pilar García-Gonzalo, M Carmen Lobo, Araceli Pérez-Sanz
This work aims to investigate the nature and the specific mechanisms by which polycarboxylic compounds participate in the tolerance of Silene vulgaris to Cr with special attention given to the rhizosphere system. This knowledge is important to use this species in the implementation of phytoremediation technologies in Cr-polluted soils. According to the results, chromium is chelated and mobilized by the citric and malic acids in plant tissues, while oxalic acid might participate in the reduction and chelation of Cr in the rhizosphere...
January 3, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28044154/biofunctional-metal-phenolic-films-from-dietary-flavonoids
#20
Nadja Bertleff-Zieschang, Md Arifur Rahim, Yi Ju, Julia A Braunger, Tomoya Suma, Yunlu Dai, Shuaijun Pan, Francesca Cavalieri, Frank Caruso
We assembled dietary, bioactive flavonoids into a metal coordinated network to form thin, surface-bound films and hollow capsules, overcoming the poor water solubility of free flavonoids. Films formed from quercetin, myricetin, luteolin and fisetin show radical scavenging activity, a renowned feature of their parent flavonoids, and can be reused over multiple cycles. These films are expected to have potential applications in the pharmaceutical and food industries.
January 3, 2017: Chemical Communications: Chem Comm
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