Giuseppe Carrà, Cristina Crocamo, Francesco Bartoli, Annamaria Lax, Martina Tremolada, Claudio Lucii, Giovanni Martinotti, Michela Nosè, Irene Bighelli, Giovanni Ostuzzi, Mariasole Castellazzi, Massimo Clerici, Corrado Barbui
OBJECTIVE: Corrected QT (QTc) interval prolongation is often associated with use of first-generation antipsychotics (FGAs). However, other factors require appropriate consideration, including age and gender, the role of other known medications associated with QTc prolongation, and severe comorbid conditions, such as co-occurring alcohol abuse/dependence. We aimed to study potential mediating roles of different, related, candidate variables on QTc. METHODS: We capitalized on data from a large (N = 2366), cross-sectional, national survey, the STAR Network QTc study, using a representative sample of people taking FGAs, and recruited from mental health services across Italy...
July 2016: Human Psychopharmacology