Neeraj Upadhyay, Annika Spottke, Anja Schneider, Daniel C Hoffmann, Ingo Frommann, Tommaso Ballarini, Klaus Fliessbach, Benjamin Bender, Hauke R Heekeren, John Dylan Haynes, Michael Ewers, Emrah Düzel, Wenzel Glanz, Laura Dobisch, Katharina Buerger, Daniel Janowitz, Johannes Levin, Adrian Danek, Stefan Teipel, Ingo Kilimann, Matthis Synofzik, Carlo Wilke, Oliver Peters, Lukas Preis, Josef Priller, Eike Jakob Spruth, Frank Jessen, Henning Boecker
Structural and functional changes in cortical and subcortical regions have been reported in behavioral variant frontotemporal dementia (bvFTD), however, a multimodal approach may provide deeper insights into the neural correlates of neuropsychiatric symptoms. In this multicenter study, we measured cortical thickness (CTh) and subcortical volumes to identify structural abnormalities in 37 bvFTD patients, and 37 age- and sex-matched healthy controls. For seed regions with significant structural changes, whole-brain functional connectivity (FC) was examined in a sub-cohort of N = 22 bvFTD and N = 22 matched control subjects to detect complementary alterations in brain network organization...
October 19, 2023: Brain Imaging and Behavior