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Canadian Neonatal Network

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https://www.readbyqxmd.com/read/29335074/trends-in-narcotics-and-sedative-use-during-mechanical-ventilation-of-preterm-infants-in-canadian-neonatal-intensive-care-units
#1
(no author information available yet)
OBJECTIVE: Mechanical ventilation (MV) in preterm infants (PTI) causes discomfort. Whether it causes pain is controversial. Meta analysis reviews of published work on PTI during MV have shown no clinically significant impact of opioids on pain scales, and hence not recommended for routine use in neonatal intensive care units (NICUs). Similarly regular use of sedative midazolam is also not recommended. Therefore we hypothesized a downward trend in narcotics and sedatives used in MV of PTI in NICUs...
January 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29325592/magnesium-sulphate-for-fetal-neuroprotection-to-prevent-cerebral-palsy-mag-cp-implementation-of-a-national-guideline-in-canada
#2
Dane A De Silva, Anne R Synnes, Peter von Dadelszen, Tang Lee, Jeffrey N Bone, Laura A Magee
BACKGROUND: Evidence supports magnesium sulphate (MgSO4) for women at risk of imminent birth at < 32-34 weeks to reduce the likelihood of cerebral palsy in the child. MAGnesium sulphate for fetal neuroprotection to prevent Cerebral Palsy (MAG-CP) was a multifaceted knowledge translation (KT) strategy for this practice. METHODS: The KT strategy included national clinical practice guidelines, a national online e-learning module and, at MAG-CP sites, educational rounds, focus group discussions and surveys of barriers and facilitators...
January 11, 2018: Implementation Science: IS
https://www.readbyqxmd.com/read/29305231/neurodevelopmental-outcomes-of-infants-born-at-29-weeks-of-gestation-admitted-to-canadian-neonatal-intensive-care-units-based-on-location-of-birth
#3
Reem Amer, Diane Moddemann, Mary Seshia, Ruben Alvaro, Anne Synnes, Kyong-Soon Lee, Shoo K Lee, Prakesh S Shah
OBJECTIVE: To compare mortality and neurodevelopmental outcomes of outborn and inborn preterm infants born at <29 weeks of gestation admitted to Canadian neonatal intensive care units (NICUs). STUDY DESIGN: Data were obtained from the Canadian Neonatal Network and Canadian Neonatal Follow-up Network databases for infants born at <29 weeks of gestation admitted to NICUs from April 2009 to September 2011. Rates of death, severe neurodevelopmental impairment (NDI), and overall NDI were compared between outborn and inborn infants at 18-21 months of age, corrected for prematurity...
January 3, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29296003/retinopathy-of-prematurity-practices-a-national-survey-of-canadian-neonatal-intensive-care-units
#4
Kourosh Sabri, Mary Angela Woodward, Bethany Easterbrook, Sandesh Shivananda
OBJECTIVE: To examine current level three Neonatal Intensive Care Unit (NICU) practices related to ROP screening and treatment. STUDY DESIGN: A cross-sectional survey was sent to 29 level three NICU's across Canada to survey current screening inclusion criteria, treatment options, supportive care and post-screening events for ROP. RESULT: 22/29 (76%) level three NICU's responded. Ten different ROP screening inclusion criteria were found to be in use with significant variation in gestational age and birth weight criteria...
January 2, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29183097/predictors-of-pda-treatment-in-preterm-neonates-who-had-received-prophylactic-indomethacin
#5
Deepak Louis, Yasser N ElSayed, Cecil Ojah, Ruben Alvaro, Prakesh S Shah, Michael Dunn
No abstract text is available yet for this article.
November 28, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28923465/continuous-glucose-monitoring-in-pregnant-women-with-type-1-diabetes-conceptt-a-multicentre-international-randomised-controlled-trial
#6
Denice S Feig, Lois E Donovan, Rosa Corcoy, Kellie E Murphy, Stephanie A Amiel, Katharine F Hunt, Elizabeth Asztalos, Jon F R Barrett, J Johanna Sanchez, Alberto de Leiva, Moshe Hod, Lois Jovanovic, Erin Keely, Ruth McManus, Eileen K Hutton, Claire L Meek, Zoe A Stewart, Tim Wysocki, Robert O'Brien, Katrina Ruedy, Craig Kollman, George Tomlinson, Helen R Murphy
BACKGROUND: Pregnant women with type 1 diabetes are a high-risk population who are recommended to strive for optimal glucose control, but neonatal outcomes attributed to maternal hyperglycaemia remain suboptimal. Our aim was to examine the effectiveness of continuous glucose monitoring (CGM) on maternal glucose control and obstetric and neonatal health outcomes. METHODS: In this multicentre, open-label, randomised controlled trial, we recruited women aged 18-40 years with type 1 diabetes for a minimum of 12 months who were receiving intensive insulin therapy...
September 15, 2017: Lancet
https://www.readbyqxmd.com/read/28910847/association-between-umbilical-catheters-and-neonatal-outcomes-in-extremely-preterm-infants
#7
Mohamed S Elboraee, Jennifer Toye, Xiang Y Ye, Prakesh S Shah, Khalid Aziz
No abstract text is available yet for this article.
September 14, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28871602/elective-transfers-of-preterm-neonates-to-regional-centres-on-non-invasive-respiratory-support-is-cost-effective-and-increases-tertiary-care-bed-capacity
#8
Hussein Zein, Kamran Yusuf, Renee Paul, Derek Kowal, Sumesh Thomas
AIM: Managing capacity at regional facilities caring for sick neonates is increasingly challenging. This study estimated the clinical and economic impact of the elective transfer of stable infants requiring nasal continuous positive airway pressure (NCPAP) from level three to level two neonatal intensive care units (NICUs) within an established clinical network of five NICUs. METHODS: We retrospectively analysed the records of 99 stable infants transferred on NCPAP between two level three NICUs and three level two NICUs in Calgary, Canada, between June 2014 and May 2016...
September 4, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28759409/head-growth-trajectory-and-neurodevelopmental-outcomes-in-preterm-neonates
#9
Kamini Raghuram, Junmin Yang, Paige T Church, Zenon Cieslak, Anne Synnes, Amit Mukerji, Prakesh S Shah
OBJECTIVES: To evaluate the association between head growth (HG) during neonatal and postdischarge periods and neurodevelopmental outcomes of preterm neonates of <29 weeks gestational age. METHODS: We conducted a retrospective cohort study of infants <29 weeks gestational
age admitted between 2009 and 2011 to participating Canadian Neonatal Network
units and followed by Canadian Neonatal Follow-Up Network clinics. Differences in head circumference (ΔHC) z score were calculated for 3 time periods, which include admission to discharge, discharge to follow-up at 16-36 months, and admission to follow-up...
July 2017: Pediatrics
https://www.readbyqxmd.com/read/28724325/use-and-timing-of-surfactant-administration-impact-on-neonatal-outcomes-in-extremely-low-gestational-age-infants-born-in-canadian-neonatal-intensive-care-units
#10
Amelie Stritzke, Khorshid Mohammad, Prakesh S Shah, Xiang Y Ye, Vineet Bhandari, Albert Akierman, Adele Harrison, Valerie Bertelle, Abhay Lodha
BACKGROUND: Use, timing and doses of surfactant in preterm infants are variable in practice in modern NICUs. OBJECTIVE: The objective of this study is to explore the association between use and timing of surfactant administration and common neonatal adverse outcomes in preterm infants with gestational age (GA) < 28 weeks. MATERIAL AND METHODS: Neonates admitted to a participating Canadian Neonatal Network NICU between 2013 and 2015 were studied...
July 31, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28714339/inhaled-and-systemic-steroid-exposure-and-neurodevelopmental-outcome-of-preterm-neonates
#11
Edmond N Kelly, Vibhuti S Shah, Jody Levenbach, Michael Vincer, Orlando DaSilva, Prakesh S Shah
OBJECTIVES: To compare death and/or neurodevelopmental outcomes of preterm infants exposed to inhaled and/or systemic steroids with those without exposure, and examine the impact of timing of exposure. METHODS: Retrospective study of infants born <29 weeks gestation and assessed at 18-21 months corrected age (CA). Neurodevelopmental impairment (NDI) was defined as any Bayley Scales of Infant and Toddler Development-III (BSID-III) score <85, cerebral palsy ≥ grade one, and visual or hearing impairment...
July 16, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28709451/comparing-very-low-birth-weight-versus-very-low-gestation-cohort-methods-for-outcome-analysis-of-high-risk-preterm-infants
#12
Louise Im Koller-Smith, Prakesh S Shah, Xiang Y Ye, Gunnar Sjörs, Yueping A Wang, Sharon S W Chow, Brian A Darlow, Shoo K Lee, Stellan Håkanson, Kei Lui
BACKGROUND: Compared to very low gestational age (<32 weeks, VLGA) cohorts, very low birth weight (<1500 g; VLBW) cohorts are more prone to selection bias toward small-for-gestational age (SGA) infants, which may impact upon the validity of data for benchmarking purposes. METHOD: Data from all VLGA or VLBW infants admitted in the 3 Networks between 2008 and 2011 were used. Two-thirds of each network cohort was randomly selected to develop prediction models for mortality and composite adverse outcome (CAO: mortality or cerebral injuries, chronic lung disease, severe retinopathy or necrotizing enterocolitis) and the remaining for internal validation...
July 14, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28582791/association-of-resident-duty-hour-reform-and-neonatal-outcomes-of-very-preterm-infants
#13
Marc Beltempo, Bruno Piedboeuf, Robert W Platt, Keith Barrington, Victoria Bizgu, Prakesh S Shah
No abstract text is available yet for this article.
December 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28499309/internal-audit-of-the-canadian-neonatal-network-data-collection-system
#14
Prakesh S Shah, Wendy Seidlitz, Priscilla Chan, Sonny Yeh, Natasha Musrap, Shoo K Lee
No abstract text is available yet for this article.
October 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28499307/admission-systolic-blood-pressure-and-outcomes-in-preterm-infants-of-%C3%A2-%C3%A2-26-weeks-gestation
#15
Yanyu Lyu, Xiang Y Ye, Tetsuya Isayama, Ruben Alvaro, Chuks Nwaesei, Keith Barrington, Shoo K Lee, Prakesh S Shah
No abstract text is available yet for this article.
November 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28494498/antenatal-exposure-to-magnesium-sulfate-and-spontaneous-intestinal-perforation-and-necrotizing-enterocolitis-in-extremely-preterm-neonates
#16
Mohamed Shalabi, Adel Mohamed, Brigitte Lemyre, Khalid Aziz, Daniel Faucher, Prakesh S Shah
No abstract text is available yet for this article.
October 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28274162/neonatal-outcomes-of-preterm-twins-according-to-mode-of-birth-and-presentation
#17
Tiffany Hunter, Jyotsna Shah, Anne Synnes, Sandesh Shivananda, Greg Ryan, Prakesh S Shah, Kellie E Murphy
PURPOSE: To compare neonatal outcomes of twins delivered <33 weeks' gestation in tertiary centers in Canada according to the mode of birth and presentation. MATERIALS AND METHODS: This retrospective cohort from the Canadian Neonatal Network database studied preterm twins born from 24 + 0 to 32 + 6 weeks' gestation between 2005 and 2012. Twins were grouped by the mode of birth: both vaginal, combined vaginal/cesarean section (CS), and both CS. Additionally, twins were grouped by the mode of presentation: both vertex, vertex/breech, breech/vertex, and both breech...
March 8, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28231603/the-effect-of-birth-order-on-neonatal-morbidity-and-mortality-in-very-preterm-twins
#18
Elad Mei-Dan, Jyotsna Shah, Shoo Lee, Prakesh S Shah, Kellie E Murphy
Objective  This retrospective cohort study examined the effect of birth order on neonatal morbidity and mortality in very preterm twins. Study Design Using 2005 to 2012 data from the Canadian Neonatal Network, very preterm twins born between 24 (0/7) and 32 (6/7) weeks of gestation were included. Odds of morbidity and mortality of second-born cotwins compared with first-born cotwins were examined by matched-pair analysis. Outcomes were neonatal death, severe brain injury (intraventricular hemorrhage grade 3 or 4 or persistent periventricular echogenicity), bronchopulmonary dysplasia, severe retinopathy of prematurity (ROP) (> stage 2), necrotizing enterocolitis (≥ stage 2), and respiratory distress syndrome (RDS)...
July 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28114678/revisiting-the-definition-of-bronchopulmonary-dysplasia-effect-of-changing-panoply-of-respiratory-support-for-preterm-neonates
#19
Tetsuya Isayama, Shoo K Lee, Junmin Yang, David Lee, Sibasis Daspal, Michael Dunn, Prakesh S Shah
Importance: Several definitions of bronchopulmonary dysplasia are clinically used; however, their validity remains uncertain considering ongoing changes in the panoply of respiratory support treatment strategies used within neonatal units. Objective: To identify the optimal definition of bronchopulmonary dysplasia that best predicts respiratory and neurodevelopmental outcomes in preterm infants. Design, Setting, and Participants: Retrospective cohort study at tertiary neonatal intensive care units...
March 1, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28002467/fetal-infant-and-maternal-outcomes-among-women-with-prolapsed-membranes-admitted-before-29-weeks-gestation
#20
Julie E Robertson, Sarka Lisonkova, Tang Lee, Dane A De Silva, Peter von Dadelszen, Anne R Synnes, K S Joseph, Robert M Liston, Laura A Magee
BACKGROUND: Few studies have examined fetal, infant and maternal mortality and morbidity among pregnant women at very early gestation with an open cervix and prolapsed membranes. We carried out a study describing the outcomes of women hospitalized with prolapsed membranes at 22-28 weeks' gestation. METHODS: We prospectively recruited women with singleton pregnancies admitted at 22-28 weeks' gestation to tertiary hospitals of the Canadian Perinatal Network between 2005 and 2009...
2016: PloS One
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