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knowledge management

Heike Ohlbrecht, Carsten Detka, Susanne Kuczyk, Bianca Lange
OBJECTIVE: The study focuses on the question of how the design of operational integration management (OIM) can be optimized, especially in small and medium-sized enterprises (SMEs), and how previous experience with operational integration management can be used to develop preventive measures to ensure employability. METHODS: The study follows a multi-perspective qualitative research design. It focused on the survey of 40 retrospective interviews with employees who have undergone different variants of the OIM...
June 2018: Die Rehabilitation
DarrenM Hutt, Salvatore Loguercio, Alexandre Rosa Campos, William E Balch
The advent of precision medicine for genetic diseases has been hampered by the large number of variants that cause familial and somatic disease, a complexity that is further confounded by the impact of genetic modifiers. To begin to understand differences in onset, progression and therapeutic response that exist among disease-causing variants, we present the proteomic variant approach (ProVarA), a proteomic method that integrates mass spectrometry with genomic tools to dissect the etiology of disease. To illustrate its value, we examined the impact of variation in cystic fibrosis (CF), where 2025 disease-associated mutations in the CF transmembrane conductance regulator (CFTR) gene have been annotated and where individual genotypes exhibit phenotypic heterogeneity and response to therapeutic intervention...
June 17, 2018: Journal of Molecular Biology
Alejandro Ortega-Beltran, Juan Moral, Ryan D Puckett, David P Morgan, Peter J Cotty, Themis J Michailides
Interactions between pathogenic and nonpathogenic fungal species in the tree canopy are complex and can determine if disease will manifest in the plant and in other organisms such as honey bees. Seasonal dynamics of fungi were studied in an almond orchard in California where experimental release of the atoxigenic biopesticide Aspergillus flavus AF36 to displace toxigenic Aspergillus strains has been conducted for five years. The presence of the vegetative compatibility group (VCG) YV36, to which AF36 belongs, in the blossoms, and the honey bees that attend these blossoms, was assessed...
2018: PloS One
Glen Gawarkiewicz, Anna Malek Mercer
Engaging ocean users, including fishing fleets, in oceanographic and ecological research is a valuable method for collecting high-quality data, improving cost efficiency, and increasing societal appreciation for scientific research. As research partners, fishing fleets provide broad access to and knowledge of the ocean, and fishers are highly motivated to use the data collected to better understand the ecosystems in which they harvest. Here, we discuss recent trends in collaborative research that have increased the capacity of and access to scientific data collection...
June 20, 2018: Annual Review of Marine Science
Kim Scribner, Iyob Tsehaye, Travis Brenden, Wendylee Stott, Jeannette Kanefsky, James Bence
Recent assessments indicate the emergence of naturally produced lake trout (Salvelinus namaycush) recruitment throughout Lake Huron in the North American Laurentian Great Lakes (>50% of fish <7 yrs). Because naturally produced fish derived from different stocked hatchery strains are unmarked, managers cannot distinguish strains contributing to natural recruitment. We used 15 microsatellite loci to identify strains of naturally produced lake trout (N=1567) collected in assessment fisheries during early (2002-2004) and late (2009-2012) sampling periods...
June 19, 2018: Journal of Heredity
Patricia Moraes Resende de Jesus, Ana Maria Martins, Nilton Di Chiacchio, Carolina Sanchez Aranda
Fabry disease is a rare lysosomal storage disorder, inherited in an X-linked manner. It is characterized by the deficiency of the enzyme alpha-galactosidase, leading to a buildup of glycosphingolipids in the cells. Angiokeratoma is one of the cutaneous manifestations of this condition, and it helps making the diagnosis. The typical site involves the genital area in men and lumbosacral, buttocks and trunk region in both sexes. We report a case of genital angiokeratoma in a woman with Fabry disease. The diagnosis is through molecular analysis and, when made early, starting treatment reduces the morbidity and mortality of the disease...
June 2018: Anais Brasileiros de Dermatologia
Anita Rotter, Luciana Paula Samorano, Maria Cecília Rivitti-Machado, Zilda Najjar Prado Oliveira, Bernardo Gontijo
Infantile hemangioma can be linked to other organ malformations. In 1996, PHACE syndrome was first defined as the association of large and segmental infantile hemangioma, usually on the face, head, or cervical region, with malformations of the posterior fossa of the brain, arterial anomalies of the central nervous system, coarctation of the aorta, cardiac defects, and ocular abnormalities. Over 300 cases of PHACE syndrome have been reported, and it is cconsidered one of the most common neurocutaneous vascular disorders in childhood...
June 2018: Anais Brasileiros de Dermatologia
Carlos Frank Viga Ramos, Raimunda da Costa Araruna, Charlene Maria Ferreira de Lima, Carmen Lúcia Albuquerque de Santana, Luiza Hiromi Tanaka
OBJECTIVE: to identify the factors that determine the implementation of educational practices of health promotion and to construct proposals to implement the educational actions of the nurses of the Family Health Units (FHU). METHOD: research-action in which individual interviews and focus group were conducted, with 17 nurses from 12 FHU in the city of Cruzeiro do Sul, Acre state, Brazil. The results were organized by the thematic analysis method. RESULTS: the thematic units emerged from the analysis: dichotomy between knowledge and doing in the production of care and health; the nurse's qualification for educational practices; and conditions favorable to health education practices...
May 2018: Revista Brasileira de Enfermagem
Alcir Escocia Dorigatti, Bruno Monteiro Tavares Pereira, Romeo Lages Simões, Juliana Rodrigues Matsuguma, Thiago Rodrigues Araujo Calderan, Gustavo Pereira Fraga
OBJECTIVE: to compare the students' performance in face-to-face and telemedicine courses for the training and necessary action in disasters, using telemedicine as an effective training tool. METHODS: online research conducted after the end of the course of preparation in disasters, carried out in-person, as well as by videoconference. We compared the performance of students in the in-person course and through telemedicine. RESULTS: in the comparison of the results obtained with the pre- and post-test data between the students who attended via telemedicine and in-person, we observed that in the two modalities there was an increase in knowledge (p<0...
2018: Revista do Colégio Brasileiro de Cirurgiões
Sharon O'Grady
AIM: The purpose of this article is to sensitize managers to the phenomenon of organisational citizenship behaviours-extra-role behaviours in which employees participate without expecting rewards and that bring forth positive impacts for the organisation. BACKGROUND: In a context of recurring budget cuts, health care organisations are expected to provide quality and safe care. Organisational citizenship behaviour is one of the measures that organisations can use to meet this mandate...
June 20, 2018: Journal of Nursing Management
Tommaso Jucker, Bonnie Wintle, Gorm Shackelford, Pierre Bocquillon, Jan Laurens Geffert, Tim Kasoar, Eszter Kovacs, Hannah S Mumby, Chloé Orland, Judith Schleicher, Eleanor R Tew, Aiora Zabala, Tatsuya Amano, Alexandra Bell, Boris Bongalov, Josephine M Chambers, Colleen Corrigan, América P Durán, Leslie-Anne Duvic-Paoli, Caroline Emilson, Jéssica Fonseca da Silva, Emma E Garnett, Elizabeth J Green, Miriam K Guth, Andrew Hacket-Pain, Amy Hinsley, Javier Igea, Martina Kunz, Sarah H Luke, William Lynam, Philip A Martin, Matheus H Nunes, Nancy Ockendon, Aly Pavitt, Charlotte L R Payne, Victoria Plutshack, Tim T Rademacher, Rebecca J Robertson, David C Rose, Anca Serban, Benno I Simmons, Erik J S Emilson, Catherine Tayleur, Claire F R Wordley, Nibedita Mukherjee
In 2008, a group of conservation scientists compiled a list of 100 priority questions for the conservation of the world's biodiversity [Sutherland et al. (2009) Conservation Biology, 23, 557-567]. However, now almost a decade later, no one has yet published a study gauging how much progress has been made in addressing these 100 high-priority questions in the peer-reviewed literature. Here we take a first step toward re-examining the 100 questions and identify key knowledge gaps that still remain. Through a combination of a questionnaire and a literature review, we evaluated each of the 100 questions on the basis of two criteria: relevance and effort...
June 20, 2018: Conservation Biology: the Journal of the Society for Conservation Biology
A Rosengren
Type 2 diabetes is a major and accelerating public health challenge. Between 1980 and 2014, a period of just 35 years, the number of adults with diabetes globally is estimated to have increased from 108 million to 422 million, due not only to sharply rising obesity rates, but also to increasing population size, and longer life expectancy. The increase in numbers is due to an increasing prevalence of diabetes worldwide, increasing population size, and longer life expectancy. Overall, worldwide age-standardized adult diabetes prevalence doubled from 4...
June 20, 2018: Journal of Internal Medicine
Su Min Ha, Jung Hwan Baek, Young Jun Choi, Sae Rom Chung, Tae Yon Sung, Tae Yong Kim, Jeong Hyun Lee
OBJECTIVE: Some authors have found little or no diagnostic benefit from repeated biopsy of benign thyroid nodules. However, to our knowledge, integration of Thyroid Imaging Reporting and Data System (TIRADS) guidelines with one biopsy for sufficient benign thyroid nodule diagnosis has not been previously described. We investigated malignancy rate and probability by using various malignancy stratification systems in initially biopsy-proven benign nodules and sought to determine their clinical relevance in management of benign thyroid nodules...
June 19, 2018: European Radiology
Mette S Herskin, Bodil H Nielsen
Across the international dairy industry, the vast majority of dairy herds have dehorned cows. Farmers choose to dehorn calves for different reasons such as easier handling of non-horned cattle and reduced risk of injuries in animals and staff. This review focuses on disbudding by use of hot-iron cautery as is practiced by dairy farmers in calves <3 months of age. We examine welfare effects of the use of NSAIDs in combination with a local anesthetic including indicators relevant for the three major welfare concerns-affective states, basic health, and functioning as well as the possibility to behave naturally...
2018: Frontiers in Veterinary Science
Martha Fang, Eqram Rahman, Krishan Mohan Kapoor
Hyaluronic acid dermal fillers are becoming popular all over the world, but due to the presence of many blood vessels in the face, there is always a small possibility of vascular complications. We present a case with the ischemic involvement of chin and neck skin after accidental submental artery involvement after hyaluronic acid filler injection for chin region. Impending skin necrosis on the chin and upper neck on the right side was diagnosed quickly by observing the skin changes in the immediate postfiller phase...
May 2018: Plastic and Reconstructive Surgery. Global Open
P V Vermaak, T R Southwood, T R Lindau, A Jester, K Oestreich
Introduction  Juvenile Idiopathic Arthritis (JIA) is the most common rheumatological condition in children and frequently affects the wrist. The roles for wrist arthroscopy and arthroscopic synovectomy (AS) in JIA are unclear. Our aim was to find the current evidence supporting its use. Methods  Systematic literature review of relevant publications from 1990 to present in the Cochrane Library, Clinical Knowledge Summaries, DynaMed, PEMSoft, NICE Guidance, MEDLINE, EMBASE, and PubMed. Results  We found no publications detailing the use of arthroscopy or AS specifically in patients with JIA involving the wrist...
July 2018: Journal of Wrist Surgery
Ben Trevaskis
Genes controlling plant development have been studied in multiple plant systems. This has provided deep insights into conserved genetic pathways controlling core developmental processes including meristem identity, phase transitions, determinacy, stem elongation, and branching. These pathways control plant growth patterns and are fundamentally important to crop biology and agriculture. This review describes the conserved pathways that control plant development, using Arabidopsis as a model. Historical examples of how plant development has been altered through selection to improve crop performance are then presented...
2018: Frontiers in Plant Science
Donna M Klingspohn
Indigenous women in Canada face a range of health and social issues including domestic violence. Indigenous women (First Nations, Inuit and Métis) are six times more likely to be killed than non-Aboriginal women (Homicide in Canada, 2014; Miladinovic and Mulligan, 2015). Aboriginal women are 2.5 times more likely to be victims of violence than non-Aboriginal women (Robertson, 2010). These and other statistics highlight a significant difference in the level of violence experienced by Indigenous women to that experienced by women in the mainstream population in Canada...
2018: Frontiers in Psychology
Nataša Toplak, Štefan Blazina, Tadej Avčin
The pathogenesis, clinical course, and response to treatment in systemic juvenile idiopathic arthritis (SJIA) differ from other types of juvenile idiopathic arthritis and are similar to other interleukin-1 (IL-1)-mediated diseases. The main cytokine involved in the pathogenesis of SJIA is IL-1β, which can be neutralized by targeted anti-IL-1 therapy. In SJIA, no antibodies have been found and there is growing evidence that it is mainly an autoinflammatory and not an autoimmune disease. Before the era of biologic therapy, treatment of SJIA was primarily based on long-term treatment with high doses of glucocorticosteroids (GCS)...
2018: Drug Design, Development and Therapy
Valerie Jomphe, Larry C Lands, Genevieve Mailhot
An optimal nutritional status is associated with better post-transplant outcomes and survival. Post-lung transplant nutrition management is however particularly challenging as lung recipients represent a very heterogeneous group of patients in terms of age, underlying diseases, weight status and presence of comorbidities. Furthermore, the post-transplant period encompasses several stages characterized by physiological and pathophysiological changes that affect nutritional status of patients and necessitate tailored nutrition management...
June 19, 2018: Nutrients
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