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Creatine supplementation

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https://www.readbyqxmd.com/read/27890303/cognitive-effects-of-creatine-monohydrate-adjunctive-therapy-in-patients-with-bipolar-depression-results-from-a-randomized-double-blind-placebo-controlled-trial
#1
REVIEW
Ricardo Alexandre Toniolo, Francy de Brito Ferreira Fernandes, Michelle Silva, Rodrigo da Silva Dias, Beny Lafer
BACKGROUND: Depressive episodes and cognitive impairment are major causes of morbidity and dysfunction in individuals suffering from bipolar disorder (BD). Novel treatment approaches that target clinical and cognitive aspects of bipolar depression are needed, and research on pathophysiology suggests that mitochondrial modulators such as the nutraceutical creatine monohydrate might have a therapeutic role for this condition. METHODS: Eighteen (N=18) patients with bipolar depression according to DSM-IV criteria who were enrollled in a 6-week, randomized, double-blind, placebo-controlled trial of creatine monohydrate 6g daily as adjunctive therapy were submitted to neuropsychological assessments (Wisconsin Card Sorting Test, Digit Span subtest of the Wechsler Adult Intelligence Scale-Third Edition, Stroop Color-Word Test, Rey-Osterrieth complex figure test, FAS Verbal Fluency Test) at baseline and week 6...
November 20, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27866187/a-pilot-study-examining-the-effects-of-8-week-whey-protein-versus-whey-protein-plus-creatine-supplementation-on-body-composition-and-performance-variables-in-resistance-trained-women
#2
Colin D Wilborn, Jordan J Outlaw, Petey W Mumford, Stacie L Urbina, Sara Hayward, Michael D Roberts, Lem W Taylor, Cliffa A Foster
AIMS: We performed a pilot study examining the effects of whey protein and creatine supplementation (PRO + CRE group) versus whey protein supplementation (PRO group) alone on body composition and performance variables in a limited number of resistance-trained women. METHODS: Seventeen resistance-trained women (21 ± 3 years, 64.7 ± 8.2 kg, 23.5 kg/m2, 26.6 ± 4.8% body fat, >6 months of training) performed a 4-day per week split-body resistance training program for 8 weeks...
November 19, 2016: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/27858383/effect-of-creatine-on-rat-sciatic-nerve-injury-a-comparative-ultrastructural-study
#3
Fatma Helvacioglu, Ersin Kandemir, Büşra Karabacak, İdil Karataş, Ahmet Peçen, İpek Ercan, Tuğçe Şençelikel, Attila Dağdeviren
AIM: Creatine is an endogenous molecule synthesized in liver, kidney and pancreas from glycin and arginine which is important for mitochondrial metabolism. It is widely used as a supplement for improving muscle mass and function for many years. As it is expected to prevent apoptosis and diminish oxidative stress it is also studied in a number of neurodegenerative diseases for its beneficial effect in recent years. We studied the effect of creatine on the peripheral nerve injury in an experimental rat crush injury model to obtain ultrastructural evidence...
October 13, 2016: Turkish Neurosurgery
https://www.readbyqxmd.com/read/27847431/effect-of-terminalia-arjuna-bark-powder-on-some-diagnostic-enzymes-in-buffalo-bubalus-bubalis-ingesting-arsenic-contaminated-water-and-fodder
#4
Subrat Kumar Dash, Shashi Nayyar, Rajesh Jindal
AIM: The study investigated the effect of Terminalia arjuna bark powder on some diagnostic enzymes related to hepatic and muscle function in buffaloes ingesting arsenic contaminated water and fodder in an arsenic affected area. MATERIALS AND METHODS: A total of 25 samples of tube well water, fodder and buffalo blood were collected through a survey from arsenic contaminated areas and 20 samples from the uncontaminated, i.e., control areas of Ludhiana district, Punjab for determination of arsenic concentration...
October 2016: Veterinary World
https://www.readbyqxmd.com/read/27826398/four-weeks-of-supplementation-with-isolated-soy-protein-attenuates-exercise-induced-muscle-damage-and-enhances-muscle-recovery-in-well-trained-athletes-a-randomized-trial
#5
Shweta Shenoy, Mrinal Dhawan, Jaspal Singh Sandhu
BACKGROUND: The effects of consumption of isolated soy protein (ISP) for a chronic period (4 weeks) on exercise induced muscle damage (EIMD) in athletic population have never been explored. OBJECTIVES: To examine the effects of ISP on muscle damage indices elicited via a bout of damaging exercise. PATIENTS AND METHODS: Forty males (20 boxers, 20 cyclists) aged 18 - 28 years were randomly assigned to two groups (ISP and Placebo) (n = 20). All participants who engaged themselves in specific, regular training of 30 hours a week during the competitive season were included in the study...
September 2016: Asian Journal of Sports Medicine
https://www.readbyqxmd.com/read/27784962/prolonged-feeding-with-guanidinoacetate-a-methyl-group-consumer-exacerbates-ethanol-induced-liver-injury
#6
Natalia A Osna, Dan Feng, Murali Ganesan, Priya F Maillacheruvu, David J Orlicky, Samuel W French, Dean J Tuma, Kusum K Kharbanda
AIM: To investigate the hypothesis that exposure to guanidinoacetate (GAA, a potent methyl-group consumer) either alone or combined with ethanol intake for a prolonged period of time would cause more advanced liver pathology thus identifying methylation defects as the initiator and stimulator for progressive liver damage. METHODS: Adult male Wistar rats were fed the control or ethanol Lieber DeCarli diet in the absence or presence of GAA supplementation. At the end of 6 wk of the feeding regimen, various biochemical and histological analyses were conducted...
October 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27775591/capsaicin-supplementation-reduces-physical-fatigue-and-improves-exercise-performance-in-mice
#7
Yi-Ju Hsu, Wen-Ching Huang, Chien-Chao Chiu, Yan-Lin Liu, Wan-Chun Chiu, Chun-Hui Chiu, Yen-Shuo Chiu, Chi-Chang Huang
Chili pepper is used as a food, seasoning and has been revered for its medicinal and health claims. It is very popular and is the most common spice worldwide. Capsaicin (CAP) is a major pungent and bioactive phytochemical in chili peppers. CAP has been shown to improve mitochondrial biogenesis and adenosine triphosphate (ATP) production. However, there is limited evidence around the effects of CAP on physical fatigue and exercise performance. The purpose of this study was to evaluate the potential beneficial effects of CAP on anti-fatigue and ergogenic functions following physiological challenge...
October 20, 2016: Nutrients
https://www.readbyqxmd.com/read/27768397/creatine-monohydrate-supplementation-does-not-augment-fitness-performance-or-body-composition-adaptations-in-response-to-four-weeks-of-high-intensity-interval-training-in-young-females
#8
Scott C Forbes, Nathan Sletten, Cody Durrer, Étienne Myette-Cote, Darren Candow, Jonathan P Little
High-intensity interval training (HIIT) has been shown to improve cardiorespiratory fitness, performance, body composition, and insulin sensitivity. Creatine (Cr) supplementation may augment responses to HIIT, leading to even greater physiological adaptations. The purpose of this study was to determine the effects of four weeks of HIIT (three sessions/week) combined with Cr supplementation in recreationally active females. Seventeen females (age = 23 ± 4 yrs; BMI = 23.4 ± 2.4) were randomly assigned to either Cr (Cr; 0...
October 21, 2016: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/27766021/dehydroepiandrosterone-supplementation-combined-with-whole-body-vibration-training-affects-testosterone-level-and-body-composition-in-mice
#9
Wen-Chyuan Chen, Yi-Ming Chen, Chi-Chang Huang, Yen-Dun Tzeng
Dehydroepiandrosterone (DHEA), the most abundant sex steroid, is primarily secreted by the adrenal gland and a precursor hormone used by athletes for performance enhancement. Whole-body vibration (WBV) is a well-known light-resistance exercise by automatic adaptations to rapid and repeated oscillations from a vibrating platform, which is also a simple and convenient exercise for older adults. However, the potential effects of DHEA supplementation combined with WBV training on to body composition, exercise performance, and hormone regulation are currently unclear...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27765800/sex-specific-associations-between-one-carbon-metabolism-indices-and-posttranslational-histone-modifications-in-arsenic-exposed-bangladeshi-adults
#10
Caitlin G Howe, Xinhua Liu, Megan N Hall, Vesna Ilievski, Marie A Caudill, Olga Malysheva, Angela M Lomax-Luu, Faruque Parvez, Abu B Siddique, Hasan Shahriar, Mohammad N Uddin, Tariqul Islam, Joseph H Graziano, Max Costa, Mary V Gamble
BACKGROUND: Posttranslational histone modifications (PTHMs) are altered by arsenic, an environmental carcinogen. PTHMs are also influenced by nutritional methyl donors involved in one-carbon metabolism (OCM), which may protect against epigenetic dysregulation. METHODS: We measured global levels of three PTHMs, which are dysregulated in cancers (H3K36me2, H3K36me3, H3K79me2), in peripheral blood mononuclear cells (PBMCs) from 324 participants enrolled in the Folic Acid and Creatine Trial, a randomized trial in arsenic-exposed Bangladeshi adults...
October 20, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27757384/effects-of-creatine-monohydrate-supplementation-and-exercise-on-depression-like-behaviors-and-raphe-5-ht-neurons-in-mice
#11
Nari Ahn, Yea Hyun Leem, Morimasa Kato, Hyukki Chang
PURPOSE: The effects of creatine and exercise on chronic stress-induced depression are unclear. In the present study, we identified the effects of 4-week supplementation of creatine monohydrate and/or exercise on antidepressant behavior and raphe 5-HT expression in a chronic mild stress-induced depressed mouse model. METHODS: Seven-week-old male C57BL/6 mice (n=48) were divided randomly into 5 groups: (1) non-stress control (CON, n=10), (2) stress control (ST-CON, n=10), (3) stress and creatine intake (ST-Cr, n=10), (4) stress and exercise (ST-Ex, n=9), and (5) combined stress, exercise, and creatine intake (ST-Cr+Ex, n=9)...
September 2016: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/27754427/probiotic-streptococcus-thermophilus-fp4-and-bifidobacterium-breve-br03-supplementation-attenuates-performance-and-range-of-motion-decrements-following-muscle-damaging-exercise
#12
Ralf Jäger, Martin Purpura, Jason D Stone, Stephanie M Turner, Anthony J Anzalone, Micah J Eimerbrink, Marco Pane, Angela Amoruso, David S Rowlands, Jonathan M Oliver
Probiotics have immunomodulatory effects. However, little is known about the potential benefit of probiotics on the inflammation subsequent to strenuous exercise. In a double-blind, randomized, placebo controlled, crossover design separated by a 21-day washout, 15 healthy resistance-trained men ingested an encapsulated probiotic Streptococcus (S.) thermophilus FP4 and Bifidobacterium (B.) breve BR03 at 5 bn live cells (AFU) concentration each, or a placebo, daily for 3 weeks prior to muscle-damaging exercise (ClinicalTrials...
October 14, 2016: Nutrients
https://www.readbyqxmd.com/read/27754180/ed-08-4-diagnosis-and-treatment-of-hypertensive-emergency-in-children
#13
Lin Shi
According to the seventh report of Joint National Committee (JNC 7), hypertensive emergency (HE), a kind of hypertensive crisis, is defined as a sudden and abrupt elevation in blood pressure so as to cause acute target organ dysfunctions, including central nervous system, cardiovascular system or kidneys. Patients with HE require immediate reduction in markedly elevated blood pressure. Currently, there are no international guidelines for children HE, so the JNC definition is commonly used. Hypertensive emergency in children is rare but a life-threatening emergency...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753625/safety-and-performance-benefits-of-arginine-supplements-for-military-personnel-a-systematic-review
#14
James R Brooks, Hellen Oketch-Rabah, Tieraona Low Dog, Dennis K J Gorecki, Marilyn L Barrett, Louis Cantilena, Mei Chung, Rebecca B Costello, Johanna Dwyer, Mary L Hardy, Scott A Jordan, Ronald J Maughan, Robin J Marles, Robert E Osterberg, Bruce E Rodda, Robert R Wolfe, Jorge M Zuniga, Luis G Valerio, Donnamaria Jones, Patricia Deuster, Gabriel I Giancaspro, Nandakumara D Sarma
CONTEXT: Dietary supplements are widely used by military personnel and civilians for promotion of health. OBJECTIVE: The objective of this evidence-based review was to examine whether supplementation with l-arginine, in combination with caffeine and/or creatine, is safe and whether it enhances athletic performance or improves recovery from exhaustion for military personnel. DATA SOURCES: Information from clinical trials and adverse event reports were collected from 17 databases and 5 adverse event report portals...
November 2016: Nutrition Reviews
https://www.readbyqxmd.com/read/27736246/the-effect-of-green-tea-and-sour-tea-hibiscus-sabdariffa-l-supplementation-on-oxidative-stress-and-muscle-damage-in-athletes
#15
Amir Hadi, Makan Pourmasoumi, Marzieh Kafeshani, Jahangir Karimian, Mohammad Reza Maracy, Mohammad Hasan Entezari
OBJECTIVE: Additional oxygen consumption during intense exercises may lead to oxidative stress and contribute to muscular fatigue. Green tea and sour tea (Hibiscus sabdariffa L.), which contain various flavonoids and polyphenols, have many healthful properties such as anticarcinogenic, anti-inflammatory, and heart protecting effects. The aim of the present study was to assess the effects of green tea and sour tea supplementation on oxidative stress and muscle damage in soccer athletes...
October 13, 2016: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/27734446/exertional-rhabdomyolysis-epidemiology-diagnosis-treatment-and-prevention
#16
Joseph J Knapik, Francis G O'Connor
Exertional rhabdomyolysis (ER) is a medical condition whereby damage to skeletal muscle is induced by excessive physical activity in otherwise healthy individuals. The individual performs so much activity that he/ she presumably depletes local muscle energy stores and muscle cells are unable to maintain cellular integrity, resulting in cell damage and the release of cellular contents, with resultant secondary complications. In the military services, the incidence of ER appeared to increase in the period 2004 to 2015...
2016: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://www.readbyqxmd.com/read/27722178/acute-lymphoblastic-leukemia-in-a-young-adult-presenting-as-hepatitis-and-acute-kidney-injury
#17
Marc Heincelman, Nithin Karakala, Don C Rockey
Acute lymphoblastic leukemia (ALL) in adults is a relatively rare malignancy. The typical presentation includes signs and symptoms associated with bone marrow failure, including fevers, infections, fatigue, and excessive bruising. In this article, we report an unusual systemic presentation of ALL in a previously healthy 18-year-old man. He initially presented with several-day history of nausea and vomiting, 10-pound weight loss, and right upper quadrant abdominal pain with evidence of acute hepatocellular liver injury (elevations in aspartate aminotransferase/alanine aminotransferase) and elevation in serum creatinine...
July 2016: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/27714631/creatine-prevents-corticosterone-induced-reduction-in-hippocampal-proliferation-and-differentiation-possible-implication-for-its-antidepressant-effect
#18
Francis L Pazini, Mauricio P Cunha, Dayane Azevedo, Julia M Rosa, André Colla, Jade de Oliveira, Ana B Ramos-Hryb, Patricia S Brocardo, Joana Gil-Mohapel, Ana Lúcia S Rodrigues
The benefits of creatine supplementation have been reported in a broad range of central nervous system diseases, including depression, although the mechanisms underlying these effects remain to be understood. In the present study, we investigated the ability of creatine to counteract the morphological and behavioral effects elicited by chronic administration of corticosterone (CORT, 20 mg/kg, p.o.) for 21 days to mice, a pharmacological model of depression that mimics exposure to stress. CORT treatment increased immobility time in the tail suspension test (TST) and forced swim test (FST), as well as latency to immobility in the FST, and decreased the sucrose consumption in the sucrose preference test (SPT)...
October 6, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27689923/cervical-spondylotic-myelopathy-metabolite-changes-in-the-primary-motor-cortex-after-surgery
#19
Izabela Aleksanderek, Stuart M K McGregor, Todd K Stevens, Sandy Goncalves, Robert Bartha, Neil Duggal
Purpose To characterize longitudinal metabolite alterations in the motor cortex of patients with cervical spondylotic myelopathy (CSM) by using proton magnetic resonance (MR) spectroscopy and to evaluate white matter integrity with diffusion-tensor imaging in patients who are recovering neurologic function after decompression surgery. Materials and Methods Informed written consent was obtained for all procedures and the study was approved by Western University's Health Sciences Research Ethics Board. Twenty-eight patients with CSM and 10 healthy control subjects were prospectively recruited and underwent two separate 3-T MR imaging examinations 6 months apart...
September 30, 2016: Radiology
https://www.readbyqxmd.com/read/27643137/ed-08-4-diagnosis-and-treatment-of-hypertensive-emergency-in-children
#20
Lin Shi
According to the seventh report of Joint National Committee (JNC 7), hypertensive emergency (HE), a kind of hypertensive crisis, is defined as a sudden and abrupt elevation in blood pressure so as to cause acute target organ dysfunctions, including central nervous system, cardiovascular system or kidneys. Patients with HE require immediate reduction in markedly elevated blood pressure. Currently, there are no international guidelines for children HE, so the JNC definition is commonly used. Hypertensive emergency in children is rare but a life-threatening emergency...
September 2016: Journal of Hypertension
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