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https://www.readbyqxmd.com/read/28332112/perspectives-on-exertional-rhabdomyolysis
#1
REVIEW
Eric S Rawson, Priscilla M Clarkson, Mark A Tarnopolsky
Exertional (exercise-induced) rhabdomyolysis is a potentially life threatening condition that has been the subject of research, intense discussion, and media attention. The causes of rhabdomyolysis are numerous and can include direct muscle injury, unaccustomed exercise, ischemia, extreme temperatures, electrolyte abnormalities, endocrinologic conditions, genetic disorders, autoimmune disorders, infections, drugs, toxins, and venoms. The objective of this article is to review the literature on exertional rhabdomyolysis, identify precipitating factors, and examine the role of the dietary supplement creatine monohydrate...
March 22, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28332111/practical-issues-in-evidence-based-use-of-performance-supplements-supplement-interactions-repeated-use-and-individual-responses
#2
REVIEW
Louise M Burke
Current sports nutrition guidelines recommend that athletes only take supplements following an evidence-based analysis of their value in supporting training outcomes or competition performance in their specific event. While there is sound evidence to support the use of a few performance supplements under specific scenarios (creatine, beta-alanine, bicarbonate, caffeine, nitrate/beetroot juice and, perhaps, phosphate), there is a lack of information around several issues needed to guide the practical use of these products in competitive sport...
March 22, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28323627/effects-of-xuebijing-injection-for-patients-with-sepsis-induced-acute-kidney-injury-after-wenchuan-earthquake
#3
Qin Yuxi, Hanlai Zhang, Yu Baili, Shihua Shi
Context • Earthquakes are devastating disasters that have claimed countless lives in the past, partially owing to the danger of direct and indirect injuries to vital organs. In the deadly earthquake that occurred in Sichuan Province of China on May 12, 2008, some victims suffered from severe damage to multiple organs and tissue and developed sepsis, a systematic inflammatory reaction resulting from infection and trauma. Xuebijing injection (CCXG) could beneficial for improvement of clinical symptoms in those patients, but no research has yet examined its potential...
March 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28323480/creatine-supplementation-and-doxorubicin-induced-skeletal-muscle-dysfunction-an-ex-vivo-investigation
#4
Eric C Bredahl, David S Hydock
Supplementing the diet with creatine (Cr) to manage chemotherapy-induced skeletal muscle weakness and fatigue has potential, but little has been done exploring it as an intervention. This study examined the effects of Cr on skeletal muscle dysfunction induced by the chemotherapy drug doxorubicin (Dox). Soleus and extensor digitorum longus (EDL) from male Sprague-Dawley rats maintained in an organ bath were incubated in Krebs-Henseleit (KH) buffer with or without creatine monohydrate (25 mM) for 30 min. Skeletal muscle was then incubated in KH buffer with or without Dox (24 μM) for an additional 30 min...
March 21, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28306393/circannual-rhythm-of-plasmatic-vitamin-d-levels-and-the-association-with-markers-of-psychophysical-stress-in-a-cohort-of-italian-professional-soccer-players
#5
Giovanni Lombardi, Jacopo Antonino Vitale, Sergio Logoluso, Giovanni Logoluso, Nino Cocco, Giulio Cocco, Antonino Cocco, Giuseppe Banfi
Adequate plasmatic Vitamin D levels are crucial to maintain calcium homeostasis and bone metabolism both in the general population and in athletes. Correct dietary supply and a regular sun exposure are fundamental for allowing the desired and effective fitness level. Past studies highlighted a scenario of Vitamin D insufficiency among professional soccer players in several countries, especially in North Europe, whilst a real deficiency in athletes is rare. The typical seasonal fluctuations of Vitamin D are wrongly described transversally in athletes belonging to teams that play at different latitudes and a chronobiologic approach studying the Vitamin D circannual rhythm in soccer players has not been described yet...
March 17, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28285432/a-low-dose-6-week-bovine-colostrum-supplementation-maintains-performance-and-attenuates-inflammatory-indices-following-a-loughborough-intermittent-shuttle-test-in-soccer-players
#6
Yiannis Kotsis, Anastasia Mikellidi, Cleopatra Aresti, Eleni Persia, Aristomenis Sotiropoulos, Demosthenes B Panagiotakos, Smaragdi Antonopoulou, Tzortzis Nomikos
PURPOSE: The aim of the study was to investigate the effect of a 6-week, low-dose bovine colostrum (BC) supplementation on exercise-induced muscle damage (EIMD) and performance decline in soccer players following the Loughborough Intermittent Shuttle Test (LIST) during a competitive season period. METHODS: In a double-blind, randomized, placebo-controlled design, two groups of soccer players were allocated to a 3.2 g/day of whey protein (WP, N = 8) or BC (N = 10) and performed a pre- and a post-supplementation LIST...
March 11, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28277227/-red-yeast-rice-induced-muscular-injuries-analysis-of-french-pharmacovigilance-database-and-literature-review
#7
Christelle Philibert, Virginie Bres, Marie-Josèphe Jean-Pastor, Claire Guy, Bénédicte Lebrun-Vignes, Perrine Robin, Véronique Pinzani, Dominique Hillaire-Buys
Red yeast rice (RYR) is a dietary supplement containing monacolins obtained by fermentation of Monascus purpureus strains. Because of its structural homology with lovastatin, monacolin K inhibits HMG-CoA reductase and shows hypocholesterolemic properties comparable to synthetic statins. We studied all cases of myopathy involving RYR reported in the French national pharmacovigilance database (6 cases) and in scientific literature (9 cases). Among these cases, 9 showed elevated creatine kinase, 3 rhabdomyolysis and 2 myalgia...
October 27, 2016: Thérapie
https://www.readbyqxmd.com/read/28261573/understanding-the-full-spectrum-of-organ-injury-following-intrapartum-asphyxia
#8
REVIEW
Domenic A LaRosa, Stacey J Ellery, David W Walker, Hayley Dickinson
Birth asphyxia is a significant global health problem, responsible for ~1.2 million neonatal deaths each year worldwide. Those who survive often suffer from a range of health issues including brain damage-manifesting as cerebral palsy (CP)-respiratory insufficiency, cardiovascular collapse, and renal dysfunction, to name a few. Although the majority of research is directed toward reducing the brain injury that results from intrapartum birth asphyxia, the multi-organ injury observed in surviving neonates is of equal importance...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28251287/nutrition-and-physical-activity-in-the-prevention-and-treatment-of-sarcopenia-systematic-review
#9
REVIEW
C Beaudart, A Dawson, S C Shaw, N C Harvey, J A Kanis, N Binkley, J Y Reginster, R Chapurlat, D C Chan, O Bruyère, R Rizzoli, C Cooper, E M Dennison
This systematic review summarizes the effect of combined exercise and nutrition intervention on muscle mass and muscle function. A total of 37 RCTs were identified. Results indicate that physical exercise has a positive impact on muscle mass and muscle function in subjects aged 65 years and older. However, any interactive effect of dietary supplementation appears to be limited. INTRODUCTION: In 2013, Denison et al. conducted a systematic review including 17 randomized controlled trials (RCTs) to explore the effect of combined exercise and nutrition intervention to improve muscle mass, muscle strength, or physical performance in older people...
March 1, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28229572/coenzyme-q10-does-not-prevent-exercise-induced-muscle-damage-and-oxidative-stress-in-sedentary-men
#10
Nilsel Okudan, Muaz Belviranli, Savaş Torlak
BACKGROUND: The objective of this study was to examine the effects of coenzyme Q10 (CoQ10) supplementation on exercise-induced muscle damage and oxidative stress in sedentary young men. In this study, a total of twenty one sedentary and healthy young men participated. METHODS: Participants were assigned at random to a CoQ10 or a placebo group employing a double-blind method. Those in the CoQ10 group ingested 200 mg CoQ10 per day for 4 weeks. Those in the placebo group ingested the same dosage of a placebo...
February 22, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28225205/greater-endurance-capacity-and-improved-dyspnoea-with-acute-oxygen-supplementation-in-idiopathic-pulmonary-fibrosis-patients-without-resting-hypoxaemia
#11
Leona M Dowman, Christine F McDonald, Steven Bozinovski, Ross Vlahos, Rebecca Gillies, Dodie Pouniotis, Catherine J Hill, Nicole S L Goh, Anne E Holland
BACKGROUND AND OBJECTIVE: Supplemental oxygen is commonly prescribed in patients with idiopathic pulmonary fibrosis (IPF), although its benefits have not been proven. The aims of this study were to investigate the effect of oxygen on oxidative stress, cytokine production, skeletal muscle metabolism and physiological response to exercise in IPF. METHODS: Eleven participants with IPF received either oxygen, at an FiO2 of 0.50, or compressed air for 1 h at rest and during a cycle endurance test at 85% of peak work rate...
February 22, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28210931/serotonin-syndrome-from-5-hydroxytryptophan-supplement-ingestion-in-a-9-month-old-labrador-retriever
#12
Hopkins Jennifer, Pardo Mariana, Bischoff Karyn
INTRODUCTION: 5-Hydroxytryptophan (5-HTP) supplements are available over the counter and labeled as sleeping aids and anxiolytics for human use. 5-HTP is a serotonin precursor and overdose can lead to serotonin syndrome. CASE REPORT: A 9-month-old female Labrador retriever was evaluated after ingestion of a 5-HTP supplement. Signs of agitation developed within 1 h of ingestion, and emesis was attempted by the owner with  3% hydrogen peroxide (H2O2) orally. On presentation, the dog was obtunded, bilaterally mydriatic and salivating...
February 16, 2017: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/28203319/iron-supplementation-effects-on-redox-status-following-aseptic-skeletal-muscle-trauma-in-adults-and-children
#13
Chariklia K Deli, Ioannis G Fatouros, Vassilis Paschalis, Athanasios Tsiokanos, Kalliopi Georgakouli, Athanasios Zalavras, Alexandra Avloniti, Yiannis Koutedakis, Athanasios Z Jamurtas
Exercise-induced skeletal muscle microtrauma is characterized by loss of muscle cell integrity, marked aseptic inflammatory response, and oxidative stress. We examined if iron supplementation would alter redox status after eccentric exercise. In a randomized, double blind crossover study, that was conducted in two cycles, healthy adults (n = 14) and children (n = 11) received daily either 37 mg of elemental iron or placebo for 3 weeks prior to and up to 72 h after an acute eccentric exercise bout. Blood was drawn at baseline, before exercise, and 72 h after exercise for the assessment of iron status, creatine kinase activity (CK), and redox status...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28199799/the-efficacy-of-protein-supplementation-during-recovery-from-muscle-damaging-concurrent-exercise
#14
Lee Eddens, Sarah Browne, Emma J Stevenson, Brad Sanderson, Ken van Someren, Glyn Howatson
This study investigated the effect of protein supplementation on recovery following muscle-damaging exercise, which was induced with a concurrent exercise design. Twenty-four well-trained male cyclists were randomised to three independent groups receiving 20 g protein hydrolysate, iso-caloric carbohydrate or low-calorific placebo supplementation, per serve. Supplement serves were provided twice daily, from the onset of the muscle-damaging exercise, for a total of four days and in addition to a controlled diet (6 g•kg<sup>-1</sup>•d<sup>-1</sup> carbohydrate, 1...
February 15, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28192673/the-benefit-of-a-supplement-with-the-antioxidant-melatonin-on-redox-status-and-muscle-damage-in-resistance-trained-athletes
#15
Roberto C Leonardo-Mendonça, Javier Ocaña-Wilhelmi, Tomás de Haro, Carlos de Teresa-Galván, Eduardo Guerra-Hernández, Iryna Rusanova, Marisol Fernández-Ortiz, Ramy Ka Sayed, Germaine Escames, Darío Acuña-Castroviejo
Previous data showed that the administration of high doses of melatonin improved the circadian system in athletes. Here, we investigated in the same experimental paradigm whether the antioxidant properties of melatonin has also beneficial effects against exercise-induced oxidative stress and muscle damage in athletes. Twenty-four athletes were treated with 100 mg.day-1 of melatonin or placebo 30 min before bedtime during four weeks in a randomized double-blind scheme. Exercise intensity was higher during the study that before starting it...
February 13, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28190980/effect-of-low-dose-short-term-creatine-supplementation-on-muscle-power-output-in-elite-youth-soccer-players
#16
Aquiles Yáñez-Silva, Cosme F Buzzachera, Ivan Da C Piçarro, Renata S B Januario, Luis H B Ferreira, Steven R McAnulty, Alan C Utter, Tacito P Souza-Junior
BACKGROUND: To determine the effects of a low dose, short-term Creatine monohydrate (Cr) supplementation (0.03 g.kg.d(-1) during 14 d) on muscle power output in elite youth soccer players. METHODS: Using a two-group matched, double blind, placebo-controlled design, nineteen male soccer players (mean age = 17.0 ± 0.5 years) were randomly assigned to either Cr (N = 9) or placebo (N = 10) group. Before and after supplementation, participants performed a 30s Wingate Anaerobic Test (WAnT) to assess peak power output (PPO), mean power output (MPO), fatigue index (FI), and total work...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28177706/the-effects-of-acute-branched-chain-amino-acid-supplementation-on-recovery-from-a-single-bout-of-hypertrophy-exercise-in-resistance-trained-athletes
#17
Mark Waldron, Kieran Whelan, Owen Jeffries, Dean Burt, Louis Howe, Stephen David Patterson
This study investigated the effects of acute branched-chain amino acid (BCAA) supplementation on recovery from exercise-induced muscle damage, among experienced resistance-trained athletes. In a double-blind matched-pairs design, 16 resistance-trained participants, routinely performing hypertrophy training, were randomly assigned to a BCAA (n = 8) or placebo (n = 8) group. The BCAAs were administered at a dosage of 0.087 g/kg body mass, with a 2:1:1 ratio of leucine, isoleucine and valine. The participants performed 6 sets of 10 full-squats at 70 % 1RM to induce muscle damage...
January 27, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28165768/minimal-muscle-damage-after-a-marathon-and-no-influence-of-beetroot-juice-on-inflammation-and-recovery
#18
Tom Clifford, Dean M Allerton, Meghan A Brown, Liam Harper, Steven Horsburgh, Karen M Keane, Emma J Stevenson, Glyn Howatson
This study examined whether beetroot juice (BTJ) would attenuate inflammation and muscle damage following a marathon. Using a double blind, independent group design, 34 runners (each having completed ca. ∼16 previous marathons) consumed either BTJ or an isocaloric placebo (PLA) for 3 days following a marathon. Maximal isometric voluntary contractions (MIVC), countermovement jumps (CMJ), muscle soreness, serum cytokines, leucocytosis, creatine kinase (CK), high sensitivity C-reactive protein (hs-CRP), and aspartate aminotransferase (AST) were measured pre, post, and 2 days after the marathon...
March 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28165424/changbai-mountain-ginseng-panax-ginseng-c-a-mey-extract-supplementation-improves-exercise-performance-and-energy-utilization-and-decreases-fatigue-associated-parameters-in-mice
#19
Guo-Dong Ma, Chun-Hui Chiu, Yi-Ju Hsu, Chien-Wen Hou, Yi-Ming Chen, Chi-Chang Huang
Changbai Mountain Ginseng (CMG, Panax ginseng C.A. Mey) is a traditional medicine commonly found in Northeast China and grows at elevations of 2000 m or higher in the Changbai Mountain Range. CMG, considered to be a "buried treasure medicine", is priced higher than other types of ginseng. However, few studies have demonstrated the effects of CMG supplementation on exercise performance, physical fatigue, and the biochemical profile. The major compound of CMG extract was characterized by electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS)...
February 5, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28163267/cornu-cervi-pantotrichum-supplementation-improves-physiological-adaptions-during-intensive-endurance-training
#20
Wen-Ching Huang, Chi-Chang Huang, Hsiao-Li Chuang, Wen-Chyuan Chen, Mei-Chich Hsu
Cornu cervi pantotrichum (CCP), used in traditional Chinese medicine, is a well-known yang-invigorating agent with multifunctional bioactivities. We previously showed, through an acute exercise challenge, that short-term CCP supplementation improved physical activities and fatigue-associated biochemical indices. Questions about the long-term effects of CCP treatment on exercise performance and physical fatigue, as well as safety, with intensive exercise training need further research. ICR-strain mice were randomly assigned to three groups: (1) sedentary control and vehicle treatment (SC); (2) exercise training with vehicle treatment (ET); (3) ET with CCP treatment at 4108 mg/kg/day (ET+CCP)...
February 3, 2017: Journal of Veterinary Medical Science
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