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https://www.readbyqxmd.com/read/29331400/locally-advanced-pancreas-cancer-staging-and-goals-of-therapy
#1
Nikolaos A Chatzizacharias, Susan Tsai, Michael Griffin, Parag Tolat, Paul Ritch, Ben George, Chad Barnes, Mohammed Aldakkak, Abdul H Khan, William Hall, Beth Erickson, Douglas B Evans, Kathleen K Christians
BACKGROUND: Patients with locally advanced pancreatic cancer have historically been considered inoperable. The purpose of this report was to determine resectability rates for patients with locally advanced pancreatic cancer based on our recently described definitions of type A and type B locally advanced pancreatic cancer. METHODS: An institutional prospective pancreas cancer database was queried for consecutive patients with locally advanced pancreatic cancer treated between January 2009 and June 2017...
January 10, 2018: Surgery
https://www.readbyqxmd.com/read/29324546/applying-precision-medicine-to-ovarian-cancer-proof-of-principle-for-a-molecular-second-look
#2
Melissa Schwartz, Olga Camacho-Vanegas, Ashley M Wood, Matthew Dashkoff, Courtney Whitelock, Timothy T Harkins, Carmel J Cohen, Ann Marie Beddoe, Peter Dottino, John A Martignetti
OBJECTIVES: The objectives of this study were to assess if targeted investigation for tumor-specific mutations by ultradeep DNA sequencing of peritoneal washes of ovarian cancer patients after primary surgical debulking and chemotherapy, and clinically diagnosed as disease free, provides a more sensitive and specific method to assess actual treatment response and tailor future therapy and to compare this "molecular second look" with conventional cytology and histopathology-based findings...
January 10, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29323616/bipolar-energy-instruments-in-laparoscopic-uterine-cancer-surgery-a-randomized-study
#3
Salih Taşkın, Yavuz Emre Şükür, Duygu Altın, Batuhan Turgay, Bulut Varlı, Volkan Baytaş, Fırat Ortaç
OBJECTIVE: To compare the perioperative outcomes of patients with uterine cancer, who were operated using advanced or conventional bipolar instruments. MATERIALS AND METHODS: Patients with clinically early-stage endometrial cancer were randomized to advanced (LigaSure) or conventional (Robi forceps) bipolar groups. Surgeries were performed by laparoscopy. Hysterectomy and bilateral salpingo-oophorectomy with retroperitoneal lymphadenectomy were done in all cases...
January 11, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29321007/staging-laparoscopy-for-locally-advanced-gastric-cancer-in-chinese-patients-a-multicenter-prospective-registry-study
#4
Ziyu Li, Zhemin Li, Lianhai Zhang, Qian Liu, Zhenjun Wang, Zhongtao Zhang, Gang Xiao, Wei Fu, Xin Wang, Yingjiang Ye, Jianchun Yu, Fei Li, Lin Chen, Shibin Wang, Jiafu Ji
BACKGROUND: Staging laparoscopy(SL) is a recommended technique for the staging of Gastric Cancer(GC) and provides the indication for a radical surgery. Considering the medical practice in China, the standardized and regular usage of SL is yet to be spread. However, existing guidelines vary and make an ambiguity of indication for SL. Besides, the specific indication for Chinese patients remains a niche. This study aims to the essential, missing information of Chinese patients and tries to normalize the indication of LS in medical practice in China...
January 10, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29289624/laparoscopic-approach-for-shull-repair-of-pelvic-floor-defects
#5
Stefano Restaino, Carlo Ronsini, Angelo Finelli, Alessandro Santarelli, Giovanni Scambia, Francesco Fanfani
Study Objective To prove the feasibility of Shull technique by a laparoscopy approach in patient affected by pelvic organ prolapse (POP) with apical loss of support. Design A step-by-step demonstration of the technique in a surgical video, including the fundamental steps for a laparoscopic uterosacral ligament suspension (USLS) (Canadian Task Force Classification III). Setting According to the National Health and Nutrition Examination Survey, approximately 3% of women in the United States report symptoms linked to POP...
December 28, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29288614/laparoscopic-hipec-for-peritoneal-carcinomatosis-from-gastric-cancer-technique-and-early-outcomes-of-our-first-cases
#6
Irina Bălescu, Daniela Godoroja, Mircea Gongu, Victor Tomulescu, Cătălin Copăescu
Gastric cancer remains one of the most aggressive malignancies, being associated with very poor therapeutic outcomes, especially in the advanced disease patients. Due to this evidence, finding a better treatment, a better control and higher survival rates is the current scientific focus of the medical community. Once the benefits of cytoreductive surgery in association with intraperitoneal hyperthermy (HIPEC) have been widely demonstrated in patients presenting peritoneal carcinomatosis from colorectal or ovarian origin,attention was focused on the possible benefit of this method in patients diagnosed with peritoneal carcinomatosis with gastric origin...
November 2017: Chirurgia
https://www.readbyqxmd.com/read/29287751/validation-of-a-visual-spatial-secondary-task-to-assess-automaticity-in-laparoscopic-skills
#7
Richard Castillo, Juan Alvarado, Pablo Moreno, Pablo Billeke, Carlos Martínez, Julián Varas, Nicolás Jarufe
INTRODUCTION: Our objective was to assess reliability and validity of a visual-spatial secondary task (VSST) as a method to measure automaticity on a basic simulated laparoscopic skill model. In motor skill acquisition, expertise is defined by automaticity. The highest level of performance with less cognitive and attentional resources characterizes this stage, allowing experts to perform multiple tasks. Conventional validated parameters as operative time, objective assessment skills scales (OSATS), and movement economy, are insufficient to distinguish if an individual has reached the more advanced learning phases, such as automaticity...
December 26, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/29275224/staging-and-surgical-approaches-in-gastric-cancer-a-systematic-review
#8
REVIEW
Natalie Coburn, Roxanne Cosby, Laz Klein, Gregory Knight, Richard Malthaner, Joseph Mamazza, C Dale Mercer, Jolie Ringash
BACKGROUND: Gastric adenocarcinoma accounted for 6.8% of new cancer cases and 8.8% of cancer deaths worldwide in 2012. Although resection is the cornerstone for cure, several aspects of surgical intervention remain controversial or sub-optimally applied at the population level. These include staging, extent of lymph node dissection (LND), optimal requirements of LN assessment, minimum resection margins, surgical technique (laparoscopic vs. open), relationship between surgical volumes and patient outcomes, and resection of stage IV gastric cancer...
December 13, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29273869/indocyanine-green-fluorescence-imaging-techniques-and-interventional-radiology-during-laparoscopic-anatomical-liver-resection-with-video
#9
Masaki Ueno, Shinya Hayami, Tetsuo Sonomura, Ryota Tanaka, Manabu Kawai, Seiko Hirono, Ken-Ichi Okada, Hiroki Yamaue
BACKGROUND: To accomplish laparoscopic anatomical liver resection, intraoperative liver segmentation is necessary. Tattooing method or Glissonian approach will be used in a similar way to that in open liver resection. Moreover, in liver segment detection, the fluorescence of indocyanine green (ICG) means it has been recognized as a useful dye. In laparoscopy, however, there are technical difficulties in performing these conventional methods, so development of new techniques is necessary for liver segment identification...
December 22, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29260126/contribution-of-an-educational-video-to-surgical-education-in-laparoscopic-appendectomy
#10
Eyüp Murat Yılmaz, Aykut Soyder, Murat Aksu, Ali Doğan Bozdağ, Şükrü Boylu, Akay Edizsoy, Şadi Ballı, Mustafa Agah Tekindal
Objective: With recent widespread advances in laparoscopy, providing education on this subject has become a significant challenge. The aim of this study was to determine the degree of contribution made by surgeons to laparoscopic education through an educational video. Material and Methods: A total of 40 volunteer general surgery residents and specialists participated in our study. Before watching the approximately six-minute educational video prepared for laparoscopic appendectomy, the participants were asked to fill out participant information forms and information measurement questionnaire forms...
2017: Turkish Journal of Surgery
https://www.readbyqxmd.com/read/29243454/the-use-of-laparoscopy-for-locally-advanced-rectal-cancer
#11
Niccolò Petrucciani, Aleix Martínez-Pérez, Giorgio Bianchi, Riccardo Memeo, Francesco Brunetti, Nicola De' Angelis
INTRODUCTION: In the last decades, the use of minimally invasive surgery has dramatically increased for the treatment of rectal cancer. However, no clear evidence exists on the role of laparoscopy for locally advanced rectal cancer, especially for cT4 tumors, after neoadjuvant therapy. EVIDENCE ACQUISITION: A literature search was performed on Embase, Medline, and Cochrane databases to identify relevant studies published up to November 2017 analyzing the outcomes of laparoscopic surgery for locally advanced rectal cancer...
December 14, 2017: Minerva Chirurgica
https://www.readbyqxmd.com/read/29234941/short-term-surgical-outcomes-of-a-randomized-controlled-trial-comparing-laparoscopic-versus-open-gastrectomy-with-d2-lymph-node-dissection-for-advanced-gastric-cancer
#12
Yan Shi, Xianhui Xu, Yongliang Zhao, Feng Qian, Bo Tang, Yingxue Hao, Huaxing Luo, Jun Chen, Peiwu Yu
BACKGROUND: Laparoscopy-assisted gastrectomy (LAG) has gained acceptance as one of the best treatments for early gastric cancer. However, the application of LAG with D2 lymph node dissection in patients with locally advanced gastric cancer (AGC) remains controversial. METHODS: We launched a prospective randomized controlled trial comparing laparoscopic and open gastrectomy with D2 lymph node dissection for locally AGC to evaluate technical safety and oncologic feasibility...
December 12, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29234710/polypoid-endometriosis-mimicking-invasive-cancer-in-an-obese-postmenopausal-tamoxifen-user
#13
William T Jaegle, Jason C Barnett, Bridget R Stralka, Nicole P Chappell
Background: Tamoxifen is a medication often used for the treatment and prevention of breast cancer. It is classically associated with several gynecological side effects to include a thickened endometrial stripe, increased uterine polyp formation, and an increased risk of uterine cancer. Rarely tamoxifen use has been associated with proliferation of endometriosis often severe enough to mimic a late-stage gynecologic malignancy. Case: A 62-year-old Gravida 0 postmenopausal female with a medical history of severe obesity, infertility, and preventative tamoxifen use presented for evaluation of gross hematuria...
November 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29218672/effect-of-academic-status-on-outcomes-of-surgery-for-rectal-cancer
#14
Kristen Cagino, Maria S Altieri, Jie Yang, Lizhou Nie, Mark Talamini, Konstantinos Spaniolas, Paula Denoya, Aurora Pryor
BACKGROUND: The purpose of our study was to investigate surgical outcomes following advanced colorectal procedures at academic versus community institutions. METHODS: The SPARCS database was used to identify patients undergoing Abdominoperineal resection (APR) and Low Anterior Resection between 2009 and 2014. Linear mixed models and generalized linear mixed models were used to compare outcomes. Laparoscopic versus open procedures, surgery type, volume status, and stoma formation between academic and community facilities were compared...
December 7, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29206557/selection-bias-in-colorectal-surgery-in-a-non-tertiary-hospital-laparoscopic-versus-open-surgery
#15
Roberto Verzaro, Simona Mattia, Teresa Rago, Francesco Casella, Andrea Ferroni, Valeria Gianfreda, Vincenza Cofini, Stefano Necozione
INTRODUCTION: Laparoscopy is used increasingly to treat malignant and benign colorectal surgical diseases. However, this practice is still not offered to all patients. Many barriers halt the widespread use of laparoscopic colorectal surgery. Both surgeon's and patient's factors contribute to limit a wider use of laparoscopy in colorectal surgery. MATERIALS AND METHODS: We retrospectively analyzed 408 consecutive colorectal resections in a 4-year period, to find out if a selection bias exists in using laparotomy or laparoscopy for colorectal surgical diseases, and which factors are associated with a poor use of laparoscopy or to a preferred laparotomy...
December 5, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29205366/diagnostic-staging-laparoscopy-in-gastric-cancer-treatment-a-cost-effectiveness-analysis
#16
Kevin Li, John G D Cannon, Sam Y Jiang, Tanmaya D Sambare, Douglas K Owens, Eran Bendavid, George A Poultsides
BACKGROUND AND OBJECTIVES: Accurate preoperative staging helps avert morbidity, mortality, and cost associated with non-therapeutic laparotomy in gastric cancer (GC) patients. Diagnostic staging laparoscopy (DSL) can detect metastases with high sensitivity, but its cost-effectiveness has not been previously studied. We developed a decision analysis model to assess the cost-effectiveness of preoperative DSL in GC workup. METHODS: Analysis was based on a hypothetical cohort of GC patients in the U...
December 4, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29205061/does-advancing-technology-improve-outcomes-comparison-of-the-da-vinci-standard-s-si-to-the-xi-robotic-platforms-during-robotic-nephroureterctomy
#17
Manish Navnitlal Patel, Ashok Hemal
INTRODUCTION: With the introduction of laparoscopy and now robotics, more patients are able to reap benefit from minimally invasive techniques during urologic surgery. With these advancing technologies it is important to evaluate whether the outlay of hospital capital actually improves patient care. To date, there has been very little literature regarding the impact of these advances on patient outcomes. In this paper, we directly compare perioperative outcomes and hospital costs between the older da Vinci Standard/S/Si platform the newer Xi robotic platform during nephroureterectomy...
December 5, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/29202966/choosing-the-right-surgical-technique-for-deep-endometriosis-shaving-disc-excision-or-bowel-resection
#18
REVIEW
Olivier Donnez, Horace Roman
Deep endometriosis (DE) remains the most difficult endometriotic entity to treat. Medical treatment for DE can reduce symptoms but does not cure the disease, and surgical removal of the lesion is required when lesions are symptomatic, impairing bowel, urinary, sexual, and reproductive functions. Although several surgical techniques such as laparoscopic bowel resection, disc excision, and rectal shaving have been described, there is no consensus regarding the choice of technique or the timing of surgery. Our review of publications reporting results and complications of surgery for rectovaginal DE reveals a relatively higher complication rate after bowel resection compared with shaving and disc excision, especially for rectovaginal fistulas, anastomotic leakage, delayed hemorrhage, and long-term bladder catheterization...
December 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/29202963/diagnosis-of-deep-endometriosis-clinical-examination-ultrasonography-magnetic-resonance-imaging-and-other-techniques
#19
REVIEW
Marc Bazot, Emile Daraï
The aim of the present review was to evaluate the contribution of clinical examination and imaging techniques, mainly transvaginal sonography and magnetic resonance imaging (MRI) to diagnose deep infiltrating (DE) locations using prisma statement recommendations. Clinical examination has a relative low sensitivity and specificity to diagnose DE. Independently of DE locations, for all transvaginal sonography techniques a pooled sensitivity and specificity of 79% and 94% are observed approaching criteria for a triage test...
December 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/29187473/melanoma-of-the-vagina-case-report-and-systematic-review-of-the-literature
#20
Violetta Rapi, Askin Dogan, Beate Schultheis, Franziska Hartmann, Günther A Rezniczek, Clemens B Tempfer
BACKGROUND: Primary melanoma of the vagina (PMV) is a rare entity. The prognosis of women with PMV is poor and there is no standardized therapy for this type of malignancy. We present the case of a 72-year-old woman with PMV (cT2, pN0, M0). CASE REPORT: Imaging studies showed no evidence of regional or distant metastases. Molecular analysis demonstrated wild-type B-Raf proto-oncogene, serine/threonine kinase (BRAF). Staging laparoscopy with pelvic lymphadenectomy and subsequent radiotherapy with 60 Gy delivered as pelvic teletherapy and vaginal brachytherapy was applied...
December 2017: Anticancer Research
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