Usha Menon, Aleksandra Gentry-Maharaj, Matthew Burnell, Andy Ryan, Naveena Singh, Ranjit Manchanda, Jatinderpal K Kalsi, Robert Woolas, Rupali Arora, Laura Casey, Anne Dawnay, Aarti Sharma, Karin Williamson, Sophia Apostolidou, Lesley Fallowfield, Alistair J McGuire, Stuart Campbell, Steven J Skates, Ian J Jacobs, Mahesh K B Parmar
BACKGROUND: In UKCTOCS, there was a decrease in the diagnosis of advanced stage tubo-ovarian cancer but no reduction in deaths in the multimodal screening group compared with the no screening group. Therefore, we did exploratory analyses of patients with high-grade serous ovarian cancer to understand the reason for the discrepancy. METHODS: UKCTOCS was a 13-centre randomised controlled trial of screening postmenopausal women from the general population, aged 50-74 years, with intact ovaries...
September 2023: Lancet Oncology