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Uricemia

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https://www.readbyqxmd.com/read/29718730/investigational-drugs-for-hyperuricemia-an-update-on-recent-developments
#1
Tristan Pascart, Pascal Richette
Introduction The significant proportion of gout patients not reaching serum urate levels below 6.0mg/dL and the debated pathogenicity of hyperuricemia (HU) itself motivate investigators to develop new drugs to decrease uricemia. Areas covered This review discusses the drugs considered to be in active development from pre-clinical to phase III studies. This review covers 11 drugs in development, including a xanthine oxidase inhibitor (topiroxostat), uricosurics (verinurad, arhalofenate, UR-1102, tranilast), dual inhibitors (RLBN1001, KUX-1151), a uricase (pergsiticase), an inhibitor of hypoxanthine production (ulodesine), and drugs with yet-to-explain mechanisms of action (levotofisopam, tuna extracts)...
May 2, 2018: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/29615104/genetic-analysis-for-rs2280205-a-g-and-rs2276961-t-c-in-slc2a9-polymorphism-for-the-susceptibility-of-gout-in-cameroonians-a-pilot-study
#2
Jan René Nkeck, Madeleine Singwé Ngandeu, Vicky Ama Moor, Jériel Pascal Nkeck, Jean-Pierre Chedjou, Aude Laetitia Ndoadoumgue, Wilfred F Mbacham
OBJECTIVE: To determine the association of non-synonymous variants rs2280205 and rs2276961 of the SLC2A9 gene to gout in Cameroonians. RESULTS: In a case-control study including 30 patients with acute gout matched to 30 healthy volunteers. We searched for polymorphism of the targeted variants using Restriction Fragment Length Polymorphism following polymerize chain reaction. Fisher exact test and Student t-test were used to compare variables, with a threshold of significance set at 0...
April 3, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29590081/metabolic-syndrome-leptin-insulin-resistance-and-uric-acid-a-trinomial-foe-for-algerian-city-dweller-adolescents-health
#3
Hamida Bouhenni, Hadjer Daoudi, Haidar Djemai, Abdelkader Rouabah, Damien Vitiello, Leila Rouabah
Background Adolescence is one of the critical periods where increased risk for long-term obesity-related complications is an important health concern. This highlights the need to perform early diagnostics based on precise biomarkers to decrease the risk of complications in adolescents with obesity. Objective To determine the relationships between serum levels of uric acid (UA), leptin and insulin with metabolic syndrome (MS) components in Algerian adolescents. Subjects Nondiabetic adolescents (n = 204)...
March 28, 2018: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/29518007/hyper-uricemia-and-gouty-access-in-the-adult-population-of-the-southeast-of-gabon-biochemical-aspects
#4
Guy Roger Ndong Atome, Rick-Leonid Ngoua Meye Misso, Cédric Sima Obiang, Richard Onanga, Dieudonné Nkogue Mba
Gout is caused by a chronic hyperuricemia whose complications are not currently well evaluated in Africa. The aim of this study was to determine the prevalence and risk factors of hyperuricemia and gout in 85 patients recruited. A total of 26 cases of hyperuricemia, i.e., 30.6% of the study population, with 12 cases of gout and seven cases of gouty access. In this population, hyperuricemia was proportional to age ( p -value < 10-4, OR = 2.6), but it was more prevalent in men, 23.5% versus 7.1% for women ( p -value = 0...
March 8, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/29427170/exploration-into-uric-and-cardiovascular-disease-uric-acid-right-for-heart-health-urrah-project-a-study-protocol-for-a-retrospective-observational-study
#5
Giovambattista Desideri, Agostino Virdis, Edoardo Casiglia, Claudio Borghi
The relevance of cardiovascular role played by levels of serum uric acid is dramatically growing, especially as cardiovascular risk factor potentially able to exert either a direct deleterious impact or a synergic effect with other cardiovascular risk factors. At the present time, it still remains undefined the threshold level of serum uric acid able to contribute to the cardiovascular risk. Indeed, the available epidemiological case studies are not homogeneous, and some preliminary data suggest that the so-called "cardiovascular threshold limit" may substantially differ from that identified as a cut-off able to trigger the acute gout attack...
February 9, 2018: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/29168965/relationships-between-metabolic-profile-hypertension-and-uric-acid-with-cardiometabolic-risk-in-adolescents-with-abdominal-obesity-impact-of-geodemographic-factors-on-the-prevalence-of-abdominal-obesity
#6
Hamida Bouhenni, Hadjer Daoudi, Haidar Djemai, Philippe Noirez, Abdelkader Rouabah, Damien Vitiello, Leila Rouabah
Background Association of hyperuricemia, dyslipidemia and high blood pressure (BP) among adolescents with high waist-to-height ratio (WHtR) remains not fully addressed and could represent a new way to diagnose adolescents early with cardiometabolic risk. Objective We aimed to determine abdominal obesity (AO) prevalence and investigate relations between AO, uric acid (UA), lipid profiles, BP and geographical patterns in adolescents. Subjects 577 and 204 Algerian students aged between 10 and 19 years were included in our epidemiological and biochemical studies, respectively...
November 23, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/29153396/the-prognostic-value-of-serum-uric-acid-in-the-acute-phase-of-ischemic-stroke-in-black-africans
#7
Yacouba Njankouo Mapoure, Chia Mark Ayeah, Hamadou Ba, Romuald Hentchoya, Henry Namme Luma
BACKGROUND: The association between hyperuricemia and stroke outcome still remains controversial worldwide. This study aims to determine the prevalence of hyperuricemia and its association with the outcome of patients with acute ischemic stroke in a tertiary care hospital. METHODS: This was a hospital-based prospective cohort study that included patients with ischemic stroke with baseline uric acid levels and 3-month post-stroke follow-up data. Associations between hyperuricemia and stroke outcomes were analyzed using multiple logistic regression, Kaplan-Meier, and Cox proportional hazards regression analysis...
March 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29075989/uric-acid-and-obesity-related-phenotypes-in-postmenopausal-women
#8
B Grygiel-Górniak, M Mosor, J Marcinkowska, J Przysławski, J Nowak
The aim of this study was to find the genetic, metabolic, and nutritional risk factors, which can be associated with uric acid (UA) level. The risk factors related to uricemia were assessed among 271 postmenopausal women without cardiometabolic disorders and hypolipidemic/hypoglycemic treatment selected from a cohort of 1423 obese postmenopausal women. The bioimpedance analysis and biochemical and genetic analyses were performed in two groups characterized by serum UA ≥ 4 mg/dL (238 μmol/L) and < 4 mg/dL...
October 26, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29051811/serum-uric-acid-levels-are-associated-with-homeostasis-model-assessment-in-obese-nondiabetic-patients-homa-and-uric-acid
#9
Cesar I Elizalde-Barrera, Teresa Estrada-García, Jose J Lozano-Nuevo, Ana K Garro-Almendaro, Catalina López-Saucedo, Alberto F Rubio-Guerra
BACKGROUND: Hyperuricemia leads to insulin resistance, whereas insulin resistance decreases renal excretion of uric acid. The aim of this study was to evaluate whether there is a correlation between serum uric acid levels with homeostatic model assessment (HOMA) 1 in nondiabetic patients. METHODS: We evaluated 88 nondiabetic patients, in whom uric acid levels were measured, in all of them HOMA of β-cell function (HOMA 1B) and HOMA of insulin resistance (HOMA 1IR) scores were performed...
October 2017: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28940111/hyperuricemia-is-associated-with-increased-apo-ai-fractional-catabolic-rates-and-dysfunctional-hdl-in-new-zealand-rabbits
#10
Miriam Martínez-Ramírez, Cristóbal Flores-Castillo, L Gabriela Sánchez-Lozada, Rocío Bautista-Pérez, Elizabeth Carreón-Torres, José Manuel Fragoso, José Manuel Rodriguez-Pérez, Fernando E García-Arroyo, Victoria López-Olmos, María Luna-Luna, Gilberto Vargas-Alarcón, Martha Franco, Oscar Pérez-Méndez
The potential cause-effect relationship between uric acid plasma concentrations and HDL functionality remains elusive. Therefore, this study aimed to explore the effect of oxonic acid (OA)-induced hyperuricemia on the HDL size distribution, lipid content of HDL subclasses, and apo AI turnover, as well as HDL functionality in New Zealand white rabbits. Experimental animals received OA 750 mg/kg/day by oral gavage during 21 days. The HDL-apo AI fractional catabolic rate (FCR) was determined by exogenous labeling with 125I, and HDL subclasses were determined by sequential ultracentrifugation and PAGE...
December 2017: Lipids
https://www.readbyqxmd.com/read/28755406/effect-of-apple-polyphenols-on-vascular-oxidative-stress-and-endothelium-function-a-translational-study
#11
Arrigo F G Cicero, Cristiana Caliceti, Federica Fogacci, Marina Giovannini, Donato Calabria, Alessandro Colletti, Maddalena Veronesi, Aldo Roda, Claudio Borghi
SCOPE: We aimed examining apple polyphenols' effect on uricemia and endothelial function in a sample of overweight subjects. METHODS AND RESULTS: This was a two-phased study. In vitro experiment aimed to evaluate apple polyphenols' ability to lower uric acid in comparison with allopurinol. In vivo study consisted in a randomized, double-blind, parallel placebo-controlled clinical trial involving 62 overweight volunteers with suboptimal values of fasting plasma glucose (100 mg/dL≤FPG≤125 mg/dL), randomized to 300 mg apple polyphenols or placebo for 8 weeks...
July 29, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28537652/efficacy-and-safety-of-very-low-calorie-ketogenic-diet-a-double-blind-randomized-crossover-study
#12
C Colica, G Merra, A Gasbarrini, A De Lorenzo, G Cioccoloni, P Gualtieri, M A Perrone, S Bernardini, V Bernardo, L Di Renzo, M Marchetti
OBJECTIVE: To verify safety respect to weight loss, cardiometabolic diseases of short-term Very low-calorie ketogenic diets (VLCKDs, <800 kcal day-1). PATIENTS AND METHODS: Randomized cross-over trial with placebo. The study had no. 2 dietary treatment (DT), conducted in two arms: (1) VLCKD1 in which 50% of protein intake is replaced with synthetic amino acids; (2) VLCKD2 with placebo. The VLCKDs (<800 kcal day-1) were different in term of protein content and quality each arm lasted three weeks (wks)...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28476518/serum-uric-acid-on-admission-predicts-in-hospital-mortality-in-patients-with-acute-coronary-syndrome
#13
Marco Magnoni, Martina Berteotti, Ferruccio Ceriotti, Vincenzo Mallia, Vittoria Vergani, Giovanni Peretto, Giulia Angeloni, Nicole Cristell, Attilio Maseri, Domenico Cianflone
BACKGROUND: Despite the association between uric acid and cardiovascular disease has been known for decades, the prognostic value of serum uric acid (UA) in all clinical manifestations of acute coronary syndrome (ACS), namely ST-elevation myocardial infarction (STEMI), NSTEMI and unstable angina, has not been definitively assessed. METHODS: This retrospective analysis included patients from previous SPAI and FAMI studies with the aim to investigate the association between serum uric acid and major adverse cardiovascular events at 180days from hospital admission...
August 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27932570/effect-of-losartan-combined-with-amlodipine-or-with-a-thiazide-on-uric-acid-levels-in-hypertensive-patients
#14
RANDOMIZED CONTROLLED TRIAL
Alberto F Rubio-Guerra, Ana K Garro-Almendaro, Cesar I Elizalde-Barrera, Juan A Suarez-Cuenca, Montserrat B Duran-Salgado
Hyperuricemia leads to endothelial dysfunction and insulin resistance, and has been associated with diseases such as hypertension. Antihypertensive drugs modify serum uric acid levels, however, few data are available about their combinations on uricemia. In this study we evaluate the effect of two combinations of losartan, with amlodipine or with hydrochlorothiazide, on serum uric acid levels in hypertensive patients. METHODS: A total of 60 hypertensive patients were randomized in two groups; group LA received losartan/amlodipine (100/5 mg) once a day, whereas LH group received losartan hydrochlorothiazide (100/12...
February 2017: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/27659401/hyperferritinemia-increases-the-risk-of-hyperuricemia-in-hfe-hereditary-hemochromatosis
#15
Jérémy Flais, Edouard Bardou-Jacquet, Yves Deugnier, Guillaume Coiffier, Aleth Perdriger, Gérard Chalès, Martine Ropert, Olivier Loréal, Pascal Guggenbuhl
OBJECTIVES: Hyperuricemia is becoming increasingly frequent in the population, and is known to be sometimes the cause of gout. The impact of uric acid is still not clearly understood, however. The iron metabolism may interact with the uric acid metabolism. The aim of this study was to examine the relationship between the serum uric acid and serum ferritin levels in a cohort of hemochromatosis patients who were homozygous for the HFE p.Cys282Tyr mutation. METHODS: 738 patients with the HFE gene mutation Cys282Tyr in the homozygous state were included in the study...
May 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27627133/inflammatory-endocrine-and-metabolic-correlates-of-fatigue-in-obese-children
#16
Pascal Barat, Marie-Claire Meiffred, Julie Brossaud, Dietmar Fuchs, Jean-Benoit Corcuff, Helene Thibault, Lucile Capuron
Alterations in endocrine functions and low-grade systemic inflammation represent fundamental characteristics of obesity. These biological systems have been repeatedly linked to fatigue symptoms. The aim of the study was to assess the relationship between fatigue dimensions and metabolic/inflammatory markers in a sample of non-diabetic obese children. The possibility that inflammation-induced alterations in tryptophan metabolism relates to specific dimensions of fatigue was also investigated in a subsample of patients...
December 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27565787/the-impact-of-blood-pressure-and-visceral-adiposity-on-the-association-of-serum-uric-acid-with-albuminuria-in-adults-without-full-metabolic-syndrome
#17
Alena Krajcoviechova, Johanne Tremblay, Peter Wohlfahrt, Jan Bruthans, Muhmmad Ramzan Tahir, Pavel Hamet, Renata Cifkova
BACKGROUND: The impact of metabolic phenotypes on the association of uricemia with urinary albumin/creatinine ratio (uACR) remains unresolved. We evaluated the association between serum uric acid and uACR in persons with 0, and 1-2 metabolic syndrome (MetS) components and determined the modification effects of visceral adiposity index (VAI), mean arterial pressure (MAP), and fasting glucose on this association. METHODS: Using data from a cross-sectional survey of a representative Czech population aged 25-64 years (n = 3612), we analyzed 1,832 persons without decreased glomerular filtration rate <60ml/min/1...
December 1, 2016: American Journal of Hypertension
https://www.readbyqxmd.com/read/27459114/protective-effect-of-grape-seed-and-skin-extract-against-diabetes-induced-oxidative-stress-and-renal-dysfunction-in-virgin-and-pregnant-rat
#18
Nourhene Oueslati, Kamel Charradi, Takwa Bedhiafi, Ferid Limam, Ezzedine Aouani
The present work deal with the effect of alloxan-induced diabetes on kidney oxidative stress and dysfunction of virgin and pregnant rat as well as the protection that may be afforded by high dosage GSSE (4g/kg) treatment. Diabetes affected negatively several kidney function parameters as creatinemia, uremia, uricemia and proteinuria without affecting kidney index. Diabetes also induced an oxidative stress characterized by increased lipid and protein oxidation, a drop in antioxidant enzyme defenses as catalase, superoxide-dismutase, glutathione-peroxidase, an alteration in transition metals as free iron, copper, selenium and associated enzymes and an increase in calpain and acetyl-cholinesterase activities...
October 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27423646/sodium-glucose-cotransporter-2-inhibition-and-the-glomerulus-a-review
#19
REVIEW
Sanjay Kalra, Vikram Singh, Dinesh Nagrale
UNLABELLED: Blood glucose-lowering treatment options generally target insulin action or beta-cell function. In diabetes, expression of the sodium-glucose cotransporter-2 (SGLT2) genes is up-regulated and renal threshold increased, resulting in increased glucose reabsorption from glomerular filtrate, reducing urinary glucose excretion and worsening the hyperglycemic condition. The SGLT2 inhibitors (SGLT2i) are a novel class of anti-diabetic drugs that lower blood glucose levels through the suppression of renal glucose reabsorption thereby promoting renal glucose excretion...
September 2016: Advances in Therapy
https://www.readbyqxmd.com/read/27247108/association-between-uric-acid-and-renal-function-in-hypertensive-patients-which-role-for-systemic-vascular-involvement
#20
Giulio Geraci, Giuseppe Mulè, Massimiliano Morreale, Claudia Cusumano, Antonella Castiglia, Francesca Gervasi, Francesco D'Ignoto, Manuela Mogavero, Calogero Geraci, Santina Cottone
The role of systemic vascular involvement in mediating the association between serum uric acid (SUA) and renal function in hypertension has not been explored. Main purpose of our study was to investigate whether morphofunctional vascular changes, assessed as carotid intima-media thickness (cIMT) and aortic pulse wave velocity (aPWV), might mediate the association between SUA and renal damage. We enrolled 523 hypertensive subjects with or without chronic kidney disease and divided population into tertiles of SUA based on sex-specific cutoff values...
July 2016: Journal of the American Society of Hypertension: JASH
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