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https://www.readbyqxmd.com/read/28032857/heme-oxygenase-1-in-the-forefront-of-a-multi-molecular-network-that-governs-cell-cell-contacts-and-filopodia-induced-zippering-in-prostate-cancer
#1
Alejandra V Paez, Carla Pallavicini, Federico Schuster, Maria Pia Valacco, Jimena Giudice, Emiliano G Ortiz, Nicolás Anselmino, Estefania Labanca, Maria Binaghi, Marcelo Salierno, Marcelo A Martí, Javier H Cotignola, Anna Woloszynska-Read, Luciana Bruno, Valeria Levi, Nora Navone, Elba S Vazquez, Geraldine Gueron
Prostate cancer (PCa) cells display abnormal expression of cytoskeletal proteins resulting in an augmented capacity to resist chemotherapy and colonize distant organs. We have previously shown that heme oxygenase 1 (HO-1) is implicated in cell morphology regulation in PCa. Here, through a multi 'omics' approach we define the HO-1 interactome in PCa, identifying HO-1 molecular partners associated with the integrity of the cellular cytoskeleton. The bioinformatics screening for these cytoskeletal-related partners reveal that they are highly misregulated in prostate adenocarcinoma compared with normal prostate tissue...
December 29, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27974247/annexin-a2-is-critical-for-blood-testis-barrier-integrity-and-spermatid-disengagement-in-the-mammalian-testis
#2
Katarzyna Chojnacka, Barbara Bilinska, Dolores D Mruk
Throughout spermatogenesis, two important processes occur at late stage VIII of the seminiferous epithelial cycle in the rat testis: preleptotene spermatocytes commence entry into the adluminal compartment and step 19 spermatids release from the seminiferous epithelium. Presently, it is not clear how these processes, which involve extensive restructuring of unique Sertoli-Sertoli and Sertoli-germ cell junctions, are mediated. We aimed to determine whether annexin A2 (ANXA2), a Ca(2+)-dependent and phospholipid-binding protein, participates in cell junction dynamics...
December 11, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27956131/annexin-a2-is-involved-in-ca-2-dependent-plasma-membrane-repair-in-primary-human-endothelial-cells
#3
Sophia Nina Koerdt, Volker Gerke
Many cells in an organism are exposed to constant and acute mechanical stress that can induce plasma membrane injuries. These plasma membrane wounds have to be resealed rapidly to guarantee cell survival. Plasma membrane resealing in response to mechanical strain has been studied in some detail in muscle, where it is required for efficient recovery after insult. However, less is known about the capacity of other cell types and tissues to perform membrane repair and the underlying molecular mechanisms. Here we show that vascular endothelial cells, which are subject to profound mechanical burden, can reseal plasma membrane holes inflicted by laser ablation...
December 9, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27892644/saliva-protein-biomarkers-to-detect-oral-squamous-cell-carcinoma-oscc
#4
R Nagler
In a recent study published in the Proceedings of the National Academy of Sciences of the U.S.A., Jau-Song Yu et al reported of their generated four-protein biomarker panel consisting of MMP1, KNG1, ANXA2, and HSPA5, as based on a risk-score scheme they established (Yu et al, 2016). This panel showed high sensitivity (87.5%) and specificity (80.5%) values in a test set to distinguish OSCC patients' saliva samples from non-OSCC patients' saliva samples. The risk score >0.4 detected 84% of the stage I OSCCs and a significant portion (42%) of the high-risk, visible, oral potentially-malignant disorders (OPMDs)...
November 28, 2016: Oral Diseases
https://www.readbyqxmd.com/read/27871932/s100a10-regulates-ulk1-localization-to-er-mitochondria-contact-sites-in-ifn-%C3%AE-triggered-autophagy
#5
Ying-Da Chen, Yi-Ting Fang, Chih-Peng Chang, Chiou-Feng Lin, Li-Jin Hsu, Shang-Rung Wu, Yen-Chi Chiu, Robert Anderson, Yee-Shin Lin
During the process of autophagy, the autophagy-related proteins are translocated to autophagosome formation sites. Here, we demonstrate that S100A10 is required for ULK1 localization to autophagosome formation sites. Silencing of S100A10 reduces IFN-γ-induced autophagosome formation. We also determined the role of annexin A2 (ANXA2), a binding partner of S100A10, which has been reported to promote phagophore assembly. Silencing of ANXA2 reduced S100A10 expression. However, overexpression of S100A10 in ANXA2-silenced cells was still able to enhance autophagosome formation, suggesting that ANXA2 regulates IFN-γ-induced autophagy through S100A10...
January 6, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/27836325/the-upregulation-of-annexin-a2-after-spinal-cord-injury-in-rats-may-have-implication-for-astrocyte-proliferation
#6
Jiajia Chen, Zhiming Cui, Saishuai Yang, Chunshuai Wu, Weidong Li, Guofeng Bao, Guanhua Xu, Yuyu Sun, Lingling Wang, Jinlong Zhang
Annexin A2 (ANXA2), is a member of the annexin family of proteins that exhibit Ca(2+)-dependent binding to phospholipids. One attractive biological function of ANXA2 is participating in DNA synthesis and cell proliferation. Previous studies have shown that ANXA2 play a role in the development of the central nervous system. However, the biological function of ANXA2 after spinal cord injury (SCI) is still with limited acquaintance. In the present study, we performed a SCI model in adult rats and investigated the dynamic changes of ANXA2 expression in the spinal cord...
October 27, 2016: Neuropeptides
https://www.readbyqxmd.com/read/27821486/heterogeneous-stromal-signaling-within-the-tumor-microenvironment-controls-the-metastasis-of-pancreatic-cancer
#7
Agnieszka A Rucki, Kelly Foley, Pingbo Zhang, Qian Xiao, Jennifer Kleponis, Annie A Wu, Rajni Sharma, Guanglan Mo, Angen Liu, Jennifer Van Eyk, Elizabeth M Jaffee, Lei Zheng
Understanding how stromal signals regulate the development of pancreatic ductal adenocarcinoma (PDAC) may suggest novel therapeutic interventions in this disease. In this study, we assessed the metastatic role of stromal signals suggested to be important in the PDAC microenvironment. Src and IGF-1R phosphorylated the prometastatic molecule Annexin A2 (AnxA2) at Y23 and Y333 in response to stromal signals HGF and IGF-1, respectively, and IGF-1 expression was regulated by the Sonic Hedgehog (Shh) pathway. Both Shh and HGF were heterogeneously expressed in PDAC stroma, and only dual inhibition of these pathways could significantly suppress AnxA2 phosphorylation, PDAC growth, and metastasis...
January 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/27773721/identification-of-krt16-as-a-target-of-an-autoantibody-response-in-complex-regional-pain-syndrome
#8
Maral Tajerian, Victor Hung, Hamda Khan, Lauren J Lahey, Yuan Sun, Frank Birklein, Heidrun H Krämer, William H Robinson, Wade S Kingery, J David Clark
OBJECTIVE: Using a mouse model of complex regional pain syndrome (CRPS), our goal was to identify autoantigens in the skin of the affected limb. METHODS: A CRPS-like state was induced using the tibia fracture/cast immobilization model. Three weeks after fracture, hindpaw skin was homogenized, run on 2-d gels, and probed by sera from fracture and control mice. Spots of interest were analyzed by liquid chromatography-mass spectroscopy (LC-MS) and the list of targets validated by examining their abundance and subcellular localization...
January 2017: Experimental Neurology
https://www.readbyqxmd.com/read/27760843/exosomal-annexin-ii-promotes-angiogenesis-and-breast-cancer-metastasis
#9
Sayantan Maji, Pankaj Chaudhary, Irina Akopova, Phung M Nguyen, Richard J Hare, Ignacy Gryczynski, Jamboor K Vishwanatha
: Tumor-derived exosomes are emerging mediators of tumorigenesis and tissue-specific metastasis. Proteomic profiling has identified Annexin II as one of the most highly expressed proteins in exosomes; however, studies focused on the biological role of exosomal Annexin II (exo-Anx II) are still lacking. In this study, mechanistic insight was sought regarding exo-Anx II and its function in angiogenesis and breast cancer metastasis. Multiple in vitro and in vivo techniques were used to study the role of exo-Anx II in angiogenesis...
January 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/27754360/rack1-mediates-the-interaction-of-p-glycoprotein-with-anxa2-and-regulates-migration-and-invasion-of-multidrug-resistant-breast-cancer-cells
#10
Yi Yang, Na Wu, Zhiyong Wang, Fei Zhang, Ran Tian, Wei Ji, Xiubao Ren, Ruifang Niu
The emergence of multidrug resistance is always associated with more rapid tumor recurrence and metastasis. P-glycoprotein (P-gp), which is a well-known multidrug-efflux transporter, confers enhanced invasion ability in drug-resistant cells. Previous studies have shown that P-gp probably exerts its tumor-promoting function via protein-protein interaction. These interactions were implicated in the activation of intracellular signal transduction. We previously showed that P-gp binds to Anxa2 and promotes the invasiveness of multidrug-resistant (MDR) breast cancer cells through regulation of Anxa2 phosphorylation...
October 13, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27704162/tnf-alpha-and-annexin-a2-inflammation-in-thrombotic-primary-antiphospholipid-syndrome
#11
REVIEW
Mirjana Bećarević
Antiphospholipid syndrome (APS) is characterized by thromboses and/or pregnancy losses. Laboratory criterion for the diagnosis of APS is the presence of antiphospholipid antibodies (anticardiolipin, anti-beta2-glycoprotein I (aβ2gpI) and lupus anticoagulant). On the one hand, the latest classification criteria for the diagnosis of APS emphasized that thrombotic manifestations of the syndrome should be without any signs of an inflammatory process, while on the other hand, some recent reports have suggested that APS is a "pro-inflammatory state...
December 2016: Rheumatology International
https://www.readbyqxmd.com/read/27701057/effect-of-metformin-on-global-gene-expression-in-liver-of-kkay-mice
#12
Zhi-Qin Liu, Xiao-Mei Song, Que-Ting Chen, Ting Liu, Ji-Tao Teng, Kun Zhou, Du-Qiang Luo
BACKGROUND: Metformin is a first-line drug for treating type 2 diabetes mellitus, yet its mechanism remains only partially understood and controversial. In this study we assessed a global gene expression profiling in liver of KKAy mice affected by metformin. This study aimed to identify the novel anti-diabetic mechanisms of metformin. METHODS: After KKAy mice were administered metformin for 5 weeks, the gene changes profile in the livers of KKAy mice were assessed by using the Agilent whole mice genome oligo microarray...
December 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/27667176/integrative-modeling-reveals-annexin-a2-mediated-epigenetic-control-of-mesenchymal-glioblastoma
#13
Teresia Kling, Roberto Ferrarese, Darren Ó hAilín, Patrik Johansson, Dieter Henrik Heiland, Fangping Dai, Ioannis Vasilikos, Astrid Weyerbrock, Rebecka Jörnsten, Maria Stella Carro, Sven Nelander
Glioblastomas are characterized by transcriptionally distinct subtypes, but despite possible clinical relevance, their regulation remains poorly understood. The commonly used molecular classification systems for GBM all identify a subtype with high expression of mesenchymal marker transcripts, strongly associated with invasive growth. We used a comprehensive data-driven network modeling technique (augmented sparse inverse covariance selection, aSICS) to define separate genomic, epigenetic, and transcriptional regulators of glioblastoma subtypes...
October 2016: EBioMedicine
https://www.readbyqxmd.com/read/27663741/saliva-protein-biomarkers-to-detect-oral-squamous-cell-carcinoma-in-a-high-risk-population-in-taiwan
#14
Jau-Song Yu, Yi-Ting Chen, Wei-Fan Chiang, Yung-Chin Hsiao, Lichieh Julie Chu, Lai-Chu See, Chi-Sheng Wu, Hui-Tzu Tu, Hsiao-Wei Chen, Chia-Chun Chen, Wei-Chao Liao, Ya-Ting Chang, Chih-Ching Wu, Che-Yi Lin, Shyun-Yeu Liu, Shu-Ti Chiou, Shu-Li Chia, Kai-Ping Chang, Chih-Yen Chien, Su-Wei Chang, Chee-Jen Chang, John D Young, Chia C Pao, Yu-Sun Chang, Leland H Hartwell
Most cases of oral squamous cell carcinoma (OSCC) develop from visible oral potentially malignant disorders (OPMDs). The latter exhibit heterogeneous subtypes with different transformation potentials, complicating the early detection of OSCC during routine visual oral cancer screenings. To develop clinically applicable biomarkers, we collected saliva samples from 96 healthy controls, 103 low-risk OPMDs, 130 high-risk OPMDs, and 131 OSCC subjects. These individuals were enrolled in Taiwan's Oral Cancer Screening Program...
October 11, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27640198/clinical-and-prognostic-role-of-annexin-a2-in-adamantinomatous-craniopharyngioma
#15
Yuelong Wang, Jiaojiao Deng, Gang Guo, Aiping Tong, Xirui Peng, Haifeng Chen, Jianguo Xu, Yi Liu, Chao You, Liangxue Zhou
Annexin A2 (AnxA2) is a highly conserved Ca2(+)-regulated membrane binding protein, which affects cell mobility and tumor progression. Adamantinomatous craniopharyngioma (AdaCP) are a kind of epithelial tumors of the sellar region with high tendency to recur. Robust biomarkers are required to predict tumor behavior and to establish follow-up individualized treatment approaches. In this study, we firstly compared four surgical AdaCP samples with normal brain by two-dimensional gel electrophoresis (2DE) proteomic analysis...
September 17, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27634758/nrbp2-overexpression-increases-the-chemosensitivity-of-hepatocellular-carcinoma-cells-via-akt-signaling
#16
Lixing Zhang, Chao Ge, Fangyu Zhao, Yang Zhang, Xin Wang, Ming Yao, Jinjun Li
Hepatocellular carcinoma is highly resistant to chemotherapy. Research data supported that cancer stem cells (CSC) may be responsible for the chemoresistance and strategies that suppress CSCs stemness could also inhibit the drug resistance. In this study, we found that nuclear receptor binding protein 2 (NRBP2) expression was downregulated in the CD133(+) hepatocellular carcinoma CSCs. Most adjacent noncancerous liver tissue analyzed expressed higher level of NRBP2 compared with cancerous tissue in hepatocellular carcinoma patients, and high NRBP2 expression indicated a better prognosis...
December 1, 2016: Cancer Research
https://www.readbyqxmd.com/read/27631133/antibodies-directed-against-annexin-a2-and-obstetric-morbidity
#17
V Salle, J Schmidt, A Smail, C Mazière, M A Conte, A Brulé, J C Mazière, E Cadet, Y E Herpe, P Duhaut
Acquired and inherited thrombophilia have both been reported to be associated with an increased risk of obstetric complications in early or later stages of pregnancy. Annexin A2 (ANXA2) is strongly expressed in vascular and placental tissues and plays a crucial role in fibrinolysis. The aim of the present study was to evaluate the prevalence of antibodies directed against ANXA2 in patients with recurrent miscarriage or obstetric complications. Anti-ANXA2 antibodies (aANXA2) were detected by ELISA in the sera from 46 women with obstetric morbidity, mainly recurrent miscarriage...
August 30, 2016: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/27574537/extracellular-vesicles-released-from-cells-exposed-to-reactive-oxygen-species-increase-annexin-a2-expression-and-survival-of-target-cells-exposed-to-the-same-conditions
#18
Ann Kari Grindheim, Anni Vedeler
Annexin A2 (AnxA2) is present in multiple cellular compartments and interacts with numerous ligands including calcium, proteins, cholesterol, negatively charged phospholipids and RNA. These interactions are tightly regulated by its post-translational modifications. The levels of AnxA2 and its Tyr23 phosphorylated form (pTyr23AnxA2) are increased in many cancers and the protein is involved in malignant cell transformation, metastasis and angiogenesis. Our previous studies of rat pheochromocytoma (PC12) cells showed that reactive oxygen species (ROS) induce rapid, simultaneous and transient dephosphorylation of nuclear AnxA2, most likely associating with PML bodies, while AnxA2 associated with F-actin at the cell cortex undergoes Tyr23 phosphorylation...
July 2016: Communicative & Integrative Biology
https://www.readbyqxmd.com/read/27496793/annals-express-annexin-a2-and-its-downstream-il-6-and-hb-egf-as-secretory-biomarkers-in-the-differential-diagnosis-of-her-2-negative-breast-cancer
#19
Praveenkumar Shetty, Vidya Shankar Patil, Rajshekar Mohan, Leonard Clinton D'souza, Anil Bapu Bargale, Basavaraj R Patil, Dinesh U S, Vikram Haridas, Shrirang P Kulkarni
BACKGROUND: AnnexinA2 (AnxA2) membrane deposition has a critical role in HB-EGF shedding as well as IL-6 secretion in breast cancer cells. This autocrine cycle has a major role in cancer cell proliferation, migration and metastasis. The objective of the study is to demonstrate AnxA2 mediated autocrine regulation via HB-EGF and IL-6 in Her-2 negative breast cancer progression. METHODS: Secretory AnxA2, HB-EGF and IL-6 were analysed in the peripheral blood sample of Her-2 negative (n=20) and positive breast cancer patients (n=16)...
August 5, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27470587/high-podocalyxin-levels-promote-cell-viability-partially-through-up-regulation-of-annexin-a2
#20
Isabelle V Leefa Chong San, Gaëlle Prost, Jennifer A Williams, Stephen E Moss, Ulrike A Nuber
Podocalyxin (PODXL) is a highly glycosylated and sialylated transmembrane protein that is up-regulated in various types of tumors and whose expression levels positively correlate with tumor grade. We previously found Podxl to be highly expressed in murine tumorigenic neural stem/progenitor cells (NSPs). Here we investigated the effects of elevated Podxl levels in these cells. NSPs overexpressing Podxl did not form brain tumors upon intracranial transplantations, indicating that high levels of this gene alone are not sufficient for tumor initiation...
September 16, 2016: Biochemical and Biophysical Research Communications
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