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https://www.readbyqxmd.com/read/29737531/specific-expression-network-analysis-of-diabetic-nephropathy-kidney-tissue-revealed-key-methylated-sites
#1
Yan-Zhe Wang, Wen-Wei Xu, Ding-Yu Zhu, Nan Zhang, Yong-Lan Wang, Miao Ding, Xin-Miao Xie, Lin-Lin Sun, Xiao-Xia Wang
Diabetic nephropathy (DN) is one of the most common and serious complication in diabetes patients. However, the evidences of gene regulation mechanism and epigenetic modification with DN remain unclear. Therefore, it is necessary to search regulating genes for early diagnosis on DN. We identified tissue specific genes through mining the gene expression omnibus (GEO) public database, enriched function by gene ontology (GO), and kyoto encyclopedia of genes and genomes (KEGG) analysis, and further compared tissue-specific network...
May 8, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29673971/changes-in-trophoblasts-gene-expression-in-response-to-perchlorate-exposition
#2
De la Peña Sol, Santiago-Roque Isela, Olivo-Vidal Zendy, Navarro-Meza Mónica, Xochihua-Rosas Irene, Arroyo-Helguera Omar
Contaminated water with chlorates is a public health problem associated with iodine deficiency. Epidemiological evidence shows that iodine deficiency is a risk factor for preeclampsia (PE). In this study we use human BeWo trophoblast cells exposed to perchlorate (KClO4 ) and changes in gene expression were analyzed by microarrays, quantitative RT-PCR (qRT-PCR) and immunoblot. The microarray analysis identified 48 transcripts up-regulated and 112 down-regulated in comparison with non-exposed trophoblast. The qRT-PCR analysis confirmed changes in GAS7, PKP2, Emilin, Dynatic 3, protocadherins 11, 15, gamma A12, EGFR, SAFB1, ACE2, ANXA2, Apoliprotein E, SREBF1, and C/EBP-β...
April 16, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29643068/hydrogen-peroxide-is-a-neuronal-alarmin-that-triggers-specific-rnas-local-translation-of-annexin-a2-and-cytoskeletal-remodeling-in-schwann-cells
#3
Samuele Negro, Marco Stazi, Marta Marchioretto, Toma Tebaldi, Umberto Rodella, Elisa Duregotti, Volker Gerke, Alessandro Quattrone, Cesare Montecucco, Michela Rigoni, Gabriella Viero
Schwann cells are key players in neuro-regeneration: they sense alarm signals released by degenerating nerve terminals and differentiate toward a pro-regenerative phenotype, with phagocytosis of nerve debris and nerve guidance. At the murine neuromuscular junction, hydrogen peroxide (H2 O2 ) is a key signal of Schwann cells activation in response to a variety of nerve injuries. Here we report that Schwann cells exposed to low doses of H2 O2 rewire the expression of several RNAs at both transcriptional and translational levels...
April 11, 2018: RNA
https://www.readbyqxmd.com/read/29629573/a-membranome-centered-approach-defines-novel-biomarkers-for-cellular-subtypes-in-the-intervertebral-disc
#4
Guus G H van den Akker, Lars M T Eijssen, Stephen M Richardson, Lodewijk W van Rhijn, Judith A Hoyland, Tim J M Welting, Jan Willem Voncken
Objective Lack of specific marker-sets prohibits definition and functional distinction of cellular subtypes in the intervertebral disc (IVD), such as those from the annulus fibrosus (AF) and the nucleus pulposus (NP). Design We recently generated immortalized cell lines from human NP and AF tissues; these comprise a set of functionally distinct clonal subtypes. Whole transcriptome analyses were performed of 12 phenotypically distinct clonal cell lines (4× NP-Responder, 4× NP-nonResponder, 2× AF-Sheet forming, and 2× AF-nonSheet forming)...
April 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29603380/identification-of-chromatin-accessible-domains-in-non-alcoholic-steatohepatitis-derived-hepatocellular-carcinoma
#5
Mekonnen Lemma Dechassa, Volodymyr Tryndyak, Aline de Conti, Wenming Xiao, Frederick A Beland, Igor P Pogribny
Non-alcoholic steatohepatitis (NASH) is becoming one of the major causes of hepatocellular carcinoma (HCC) in the United States and Western countries; however, the molecular mechanisms associated with NASH-related liver carcinogenesis are not well understood. In the present study, we investigated cancer-associated chromatin alterations using a model that resembles the development of NASH-related HCC in humans. An assay for transposase-accessible chromatin with high throughput sequencing (ATAC-seq) identified 1,677 tumor-specific chromatin-accessible regions in NASH-derived HCC tissue samples...
March 30, 2018: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29598816/annexin-a2-mediated-cancer-progression-and-therapeutic-resistance-in-nasopharyngeal-carcinoma
#6
REVIEW
Chang-Yu Chen, Yung-Song Lin, Chien-Ho Chen, Yin-Ju Chen
Nasopharyngeal carcinoma (NPC) is a head and neck cancer with poor clinical outcomes and insufficient treatments in Southeast Asian populations. Although concurrent chemoradiotherapy has improved recovery rates of patients, poor overall survival and low efficacy are still critical problems. To improve the therapeutic efficacy, we focused on a tumor-associated protein called Annexin A2 (ANXA2). This review summarizes the mechanisms by which ANXA2 promotes cancer progression (e.g., proliferation, migration, the epithelial-mesenchymal transition, invasion, and cancer stem cell formation) and therapeutic resistance (e...
March 29, 2018: Journal of Biomedical Science
https://www.readbyqxmd.com/read/29570731/anxa2-attenuates-osteoblast-growth-and-is-associated-with-hip-bmd-and-osteoporotic-fracture-in-chinese-elderly
#7
Xu Zhou, Long-Fei Wu, Wen-Yu Wang, Xin Lu, Zhen-Huan Jiang, Yun-Hong Zhang, Ding-Hua Jiang, Jian-Nong Jiang, Hong-Qing Gao, Shu-Feng Lei, Fei-Yan Deng
Low bone mineral density (BMD) is a risk factor of osteoporotic fracture (OF). Peripheral blood monocytes (PBM) can differentiate into osteoclasts to resorb bone. It was known that PBM-expressed Anxa2 protein is associated with BMD, and extracellular Anxa2 protein promotes osteoclastogenesis. This study aimed to test 1) whether Anxa2 protein level in PBM differs significantly between subjects with OF and without fracture history (NF); 2) whether Anxa2 level in plasma is associated with BMD; 3) how Anxa2 protein at various concentrations would affect osteoblastic activity in vitro...
2018: PloS One
https://www.readbyqxmd.com/read/29568351/targeting-of-embryonic-annexin-a2-expressed-on-ovarian-and-breast-cancer-by-the-novel-monoclonal-antibody-2448
#8
Simeon Cua, Heng Liang Tan, Wey Jia Fong, Angela Chin, Ally Lau, Vanessa Ding, Zhiwei Song, Yuansheng Yang, Andre Choo
Monoclonal antibodies (mAbs) play an increasingly important role in cancer therapy. To address the wide heterogeneity of the disease, the identification of novel antigen targets and the development of mAbs against them are needed. Our lab previously generated a panel of mAbs against human embryonic stem cells (hESC) using a whole cell immunization approach in mice. These mAbs can potentially target oncofetal antigens and be repurposed for antibody or antibody drug conjugate (ADC) therapy. From this panel, the novel IgG1 2448 was found to bind surface antigens on hESC and multiple cancer cell lines...
March 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29491166/annexin-a2-mediates-the-localization-of-measles-virus-matrix-protein-at-the-plasma-membrane
#9
Ritsuko Koga, Marie Kubota, Takao Hashiguchi, Yusuke Yanagi, Shinji Ohno
Annexins are a family of structurally related proteins that bind negatively charged membrane phospholipids in a Ca2+ -dependent manner. Annexin A2 (AnxA2), a member of the family, has been implicated in a variety of cellular functions including the organization of membrane domains, vesicular trafficking and cell-cell adhesion. AnxA2 generally forms the heterotetrameric complex with a small Ca2+ -binding protein S100A10. Measles virus (MV), a member of the family Paramyxoviridae , is an enveloped virus with a nonsegmented negative strand RNA genome...
February 28, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29462818/effects-of-microrna-206-on-osteosarcoma-cell-proliferation-apoptosis-migration-and-invasion-by-targeting-anxa2-through-the-akt-signaling-pathway
#10
Bao-Long Pan, Zong-Wu Tong, Ling Wu, Li Pan, Jun-E Li, You-Guang Huang, Shu-De Li, Shi-Xun Du, Xu-Dong Li
BACKGROUND/AIMS: This study aimed to investigate the mechanism by which microRNA-206 (miR-206) affects the proliferation, apoptosis, migration and invasion of osteosarcoma (OS) cells by targeting ANXA2 via the AKT signaling pathway. METHODS: A total of 132 OS tissues and 120 osteochondroma tissues were examined in this study. The targeting relationship between miR-206 and ANXA2 was verified with a dual-luciferase reporter assay. The miR-206 expression and ANXA2, AKT, PARP, FASN, Survivin, Bax, Mcl-1 and Bcl-1 mRNA and protein expression in the above two groups were examined by qRT-PCR and western blotting...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29444639/differential-expression-of-mrna-isoforms-in-the-skeletal-muscle-of-pigs-with-distinct-growth-and-fatness-profiles
#11
Tainã Figueiredo Cardoso, Raquel Quintanilla, Anna Castelló, Rayner González-Prendes, Marcel Amills, Ángela Cánovas
BACKGROUND: The identification of genes differentially expressed in the skeletal muscle of pigs displaying distinct growth and fatness profiles might contribute to identify the genetic factors that influence the phenotypic variation of such traits. So far, the majority of porcine transcriptomic studies have investigated differences in gene expression at a global scale rather than at the mRNA isoform level. In the current work, we have investigated the differential expression of mRNA isoforms in the gluteus medius (GM) muscle of 52 Duroc HIGH (increased backfat thickness, intramuscular fat and saturated and monounsaturated fatty acids contents) and LOW pigs (opposite phenotype, with an increased polyunsaturated fatty acids content)...
February 14, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29416802/prognostic-impact-of-anxa1-and-anxa2-gene-expression-in-triple-negative-breast-cancer
#12
Lee D Gibbs, Jamboor K Vishwanatha
Objective: Previous studies have shown Annexin A1 (AnxA1) and Annexin A2 (AnxA2) association with the aggressive behavior of Triple Negative Breast Cancer (TNBC). Our aim was to determine the correlation of AnxA1 and AnxA2 with poor prognosis of TNBC patients. Methods: We analyzed the gene expression of the human annexin family from microarray datasets and correlated with clinical outcomes to determine their ability to predict prognosis. Results: Within a mean follow-up time of 57...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29390120/development-and-validation-of-a-small-snp-panel-for-feed-efficiency-in-beef-cattle
#13
M K Abo-Ismail, N Lansink, E Akanno, B K Karisa, J J Crowley, S S Moore, E Bork, P Stothard, J A Basarab, G S Plastow
The objective of this study was to develop and validate a customized cost-effective single nucleotide polymorphism (SNP) panel for genetic improvement of feed efficiency in beef cattle. The SNPs identified in previous association studies and through extensive analysis of candidate genomic regions and genes, were screened for their functional impact and allele frequency in Angus and Hereford breeds used as validation candidates for the panel. Association analyses were performed on genotypes of 159 SNPs from new samples of Angus (n = 160), Hereford (n = 329), and Angus-Hereford crossbred (n = 382) cattle using allele substitution and genotypic models in ASReml...
March 6, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29365774/identifying-ldl-c-associated-variants-in-the-annexin-a2-anxa2-gene
#14
Roaa Hani Fairoozy, Jon White, Jackie Cooper, Lasse Folkersen, Claudia Giambartolomei, Anastasia Kalea, Thomas Grewal, Steve Humphries
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29343717/the-role-of-nf%C3%AE%C2%BAb-in-spheroid-formation-of-human-breast-cancer-cells-cultured-on-the-random-positioning-machine
#15
Sascha Kopp, Jayashree Sahana, Tawhidul Islam, Asbjørn Graver Petersen, Johann Bauer, Thomas J Corydon, Herbert Schulz, Kathrin Saar, Norbert Huebner, Lasse Slumstrup, Stefan Riwaldt, Markus Wehland, Manfred Infanger, Ronald Luetzenberg, Daniela Grimm
Human MCF-7 breast cancer cells were exposed to a Random Positioning Machine (RPM). After 24 hours (h) the cells grew either adherently within a monolayer (AD) or within multicellular spheroids (MCS). AD and MCS populations were separately harvested, their cellular differences were determined performing qPCR on genes, which were differently expressed in AD and MCS cells. Gene array technology was applied to detect RPM-sensitive genes in MCF-7 cells after 24 h. Furthermore, the capability to form multicellular spheroids in vitro was compared with the intracellular distribution of NF-kappaB (NFκB) p65...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29326439/lung-fibroblasts-promote-metastatic-colonization-through-upregulation-of-stearoyl-coa-desaturase-1-in-tumor-cells
#16
Guanghua Liu, Shi Feng, Lin Jia, Chunying Wang, Yan Fu, Yongzhang Luo
As a rate-limiting step in metastasis, metastatic colonization requires survival signals from supportive stroma. However, the mechanisms driving this process are incompletely understood. Here, we showed that the proliferation of B16F10 cells was promoted when cocultured with lung fibroblasts. Meanwhile, co-injection of B16F10 tumor cells with mouse lung fibroblasts significantly increased lung metastasis. Based on GEO database, we identified stearoyl-CoA desaturase 1 (SCD1) as a novel factor promoting metastatic colonization...
March 2018: Oncogene
https://www.readbyqxmd.com/read/29291003/pseudogenes-of-annexin-a2-novel-prognosis-biomarkers-for-diffuse-gliomas
#17
Shuang Li, Hecun Zou, Ying-Ying Shao, Ying Mei, Yu Cheng, Dong-Li Hu, Zhi-Rong Tan, Hong-Hao Zhou
Diffuse gliomas is a kind of common malignant primary brain tumor. Pseudogenes have multilayered biological function in the progression of human cancers. In this study, Differentially Expressed Pseudogenes (DEPs) between glioblastomas and non-tumor controls were found by bioinformatics analysis, of which the annexin A2 pseudogenes (ANXA2P1, ANXA2P2 and ANXA2P3) were significantly up-regulated, along with the parent gene annexin A2 (ANXA2 ) . Among four glioblastoma subtypes, ANXA2P1 and ANXA2P2 were preferentially expressed in mesenchymal subtype and less expressed in proneural subtype...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29290958/stromal-annexin-a2-expression-is-predictive-of-decreased-survival-in-pancreatic-cancer
#18
Adrian G Murphy, Kelly Foley, Agnieszka A Rucki, Tao Xia, Elizabeth M Jaffee, Chiung-Yu Huang, Lei Zheng
Pancreatic ductal adenocarcinoma (PDA) is renowned for high rates of metastasis and poor survival. Its notoriously dense fibrotic stroma contributes to chemoresistance. Stromal signaling in PDA is recognized for its multiple roles in regulating tumor invasion and metastasis. However, no stromal biomarker which can predict survival in PDA exists. Annexin A2 (AnxA2) was formerly identified as a metastasis-associated protein in PDA and tumoral overexpression is associated with poor survival. In this study, we examined AnxA2 expression in the tumor microenvironment in a preclinical model of PDA which suggests its role in tumor colonization...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228983/characterization-of-interactions-between-hepatitis-c-virus-ns5b-polymerase-annexin-a2-and-rna-effects-on-ns5b-catalysis-and-allosteric-inhibition
#19
Sara M Ø Solbak, Eldar Abdurakhmanov, Anni Vedeler, U Helena Danielson
BACKGROUND: Direct acting antivirals (DAAs) provide efficient hepatitis C virus (HCV) therapy and clearance for a majority of patients, but are not available or effective for all patients. They risk developing HCV-induced hepatocellular carcinoma (HCC), for which the mechanism remains obscure and therapy is missing. Annexin A2 (AnxA2) has been reported to co-precipitate with the non-structural (NS) HCV proteins NS5B and NS3/NS4A, indicating a role in HCC tumorigenesis and effect on DAA therapy...
December 11, 2017: Virology Journal
https://www.readbyqxmd.com/read/29217762/sirt6-is-a-target-of-regulation-by-ube3a-that-contributes-to-liver-tumorigenesis-in-an-anxa2-dependent-manner
#20
Saishruti Kohli, Abhishek Bhardwaj, Richa Kumari, Sanjeev Das
UBE3A is an E3 ubiquitin ligase well known for its role in the proteasomal degradation of p53 in human papillomavirus (HPV)-associated cancers. Here we report that UBE3A ubiquitylates and triggers degradation of the tumor-suppressive sirtuin SIRT6 in hepatocellular carcinoma. UBE3A ubiquitylated the highly conserved Lys160 residue on SIRT6. FOXO1-mediated transcriptional repression of UBE3A was sufficient to stabilize SIRT6 and to epigenetically repress ANXA2 , a key mediator of UBE3A oncogenic function. Thus, UBE3A-mediated SIRT6 degradation promoted the proliferative capacity, migration potential, and invasiveness of cells...
February 1, 2018: Cancer Research
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