keyword
https://read.qxmd.com/read/38088940/plasma-and-peritoneal-fluid-annexin-a2-levels-in-patients-with-endometriosis
#21
JOURNAL ARTICLE
Michal Zygarowicz, Joanna Kacperczyk-Bartnik, Janusz Sierdzinski, Cezary Wojtyla, Piotr Pierzynski, Grzegorz Manka, Mariusz Kiecka, Robert Z Spaczynski, Piotr Piekarski, Beata Banaszewska, Artur Jakimiuk, Tadeusz Issat, Wojciech Rokita, Jakub Mlodawski, Maria Szubert, Piotr Sieroszewski, Grzegorz Raba, Kamil Szczupak, Tomasz Kluz, Marek Kluza, Michal Lipa, Damian Warzecha, Miroslaw Wielgos, Ewa Koc-Zorawska, Marcin Zorawski, Piotr Laudanski
INTRODUCTION: Endometriosis is an inflammatory-related reproductive age disease characterized by the presence of endometrial cells outside the uterine cavity. Current laboratory practice does not provide specific markers for detecting and assessing the advancement of endometriosis in either plasma or peritoneal fluid. The severity of disease is assessed in stages from I to IV based on the results of laparoscopic inspection. The protein annexin A2 (ANXA2) has been reported to be associated with inflammatory processes...
2023: Journal of Inflammation Research
https://read.qxmd.com/read/38088892/calcium-influx-promotes-plekhg4b-localization-to-cell-cell-junctions-and-regulates-the-integrity-of-junctional-actin-filaments
#22
JOURNAL ARTICLE
Komaki Ninomiya, Kai Ohta, Ukyo Kawasaki, Shuhei Chiba, Takanari Inoue, Erina Kuranaga, Kazumasa Ohashi, Kensaku Mizuno
PLEKHG4B is a Cdc42-targeting guanine-nucleotide exchange factor implicated in forming epithelial cell-cell junctions. Here we explored the mechanism regulating PLEKHG4B localization. PLEKHG4B localized to the basal membrane in normal Ca2+ medium but accumulated at cell-cell junctions upon ionomycin treatment. Ionomycin-induced junctional localization of PLEKHG4B was suppressed upon disrupting its annexin-A2 (ANXA2)-binding ability. Thus, Ca2+ influx and ANXA2 binding are crucial for PLEKHG4B localization to cell-cell junctions...
December 13, 2023: Molecular Biology of the Cell
https://read.qxmd.com/read/38061137/the-inhibitory-effects-of-epigallocatechin-3-gallate-on-calcium-oxalate-monohydrate-crystal-growth-aggregation-and-crystal-cell-adhesion
#23
JOURNAL ARTICLE
Rattiyaporn Kanlaya, Rasiyakapat Kuljiratansiri, Paleerath Peerapen, Visith Thongboonkerd
Epigallocatechin-3-gallate (EGCG), a predominant phytochemical in tea plant, has been reported to prevent kidney stone formation but with vague mechanism. We investigated modulatory effects of EGCG (at 0.1-100 µM) on calcium oxalate monohydrate (COM) crystals at various stages of kidney stone development. EGCG significantly increased crystal size (at 1-100 µM), but decreased crystal number (at 10-100 µM), resulting in unchanged crystal mass and volume. Interestingly, EGCG at 10-100 µM caused morphological change of the crystals from typical monoclinic prismatic to coffee-bean-like shape, which represented atypical/aberrant form of COM as confirmed by attenuated total reflection - Fourier transform infrared (ATR-FTIR) spectroscopy...
December 6, 2023: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38037097/single-cell-rna-sequencing-unveils-lrg1-s-role-in-cerebral-ischemia%C3%A2-reperfusion-injury-by-modulating-various-cells
#24
JOURNAL ARTICLE
Zhaohui Ruan, Guosheng Cao, Yisong Qian, Longsheng Fu, Jinfang Hu, Tiantian Xu, Yaoqi Wu, Yanni Lv
BACKGROUND AND PURPOSE: Cerebral ischemia‒reperfusion injury causes significant harm to human health and is a major contributor to stroke-related deaths worldwide. Current treatments are limited, and new, more effective prevention and treatment strategies that target multiple cell components are urgently needed. Leucine-rich alpha-2 glycoprotein 1 (Lrg1) appears to be associated with the progression of cerebral ischemia‒reperfusion injury, but the exact mechanism of it is unknown...
November 30, 2023: Journal of Neuroinflammation
https://read.qxmd.com/read/38018145/prognostic-significance-of-annexin-a2-and-tumor-associated-macrophages-tams-in-metastatic-renal-cell-carcinoma-and-their-relation-to-sunitinib-resistance
#25
JOURNAL ARTICLE
Nehal Abd El-Ghaffar Heabah, Sara A Darwish, Fatma MKh Ibrahim
Sunitinib, an antiangiogenic tyrosine kinase inhibitor, is the main treatment for metastatic renal cell carcinoma (mRCC). Development of resistance is a major obstacle against therapy success. The aim of this study was to assess annexin A2 and CD163+ tumor associated macrophages (TAMs) immunohistochemical expression in 50 mRCC cases as regard to patients' prognosis and Sunitinib response. Also, to assess the correlation between annexin A2 and TAMs expression. High annexin A2 expression and TAMs density were associated with serum calcium level ( P  = 0...
November 28, 2023: Journal of Immunoassay & Immunochemistry
https://read.qxmd.com/read/38001391/promoter-hypomethylation-upregulates-anxa2-expression-in-pancreatic-cancer-and-is-associated-with-poor-prognosis
#26
JOURNAL ARTICLE
Soumaya Menadi, Burak Kucuk, Ercan Cacan
Pancreatic cancer (PC) is one of the world's most aggressive and deadly cancers, owing to non-specific early clinical symptoms, late-stage diagnosis, and poor survival. Therefore, it is critical to identify specific biomarkers for its early diagnosis. Annexin A2 (ANXA2) is a calcium-dependent phospholipid-binding protein that has been reported to be upregulated in several cancer types, making it an emerging biomarker and potential cancer therapeutic target. However, the mechanism underlying the regulation of ANXA2 overexpression is still unclear...
November 24, 2023: Biochemical Genetics
https://read.qxmd.com/read/37978536/lppa-is-a-novel-plasminogen-receptor-of-mycoplasma-bovis-that-contributes-to-adhesion-by-binding-the-host-extracellular-matrix-and-annexin-a2
#27
JOURNAL ARTICLE
Shuang Liu, Zhangcheng Li, Shimei Lan, Huafang Hao, Xiangrui Jin, Jinjia Liang, Ahmed Adel Baz, Xinmin Yan, Pengcheng Gao, Shengli Chen, Yuefeng Chu
Mycoplasma bovis is responsible for various inflammatory diseases in cattle. The prevention and control of M. bovis are complicated by the absence of effective vaccines and the emergence of multidrug-resistant strains, resulting in substantial economic losses worldwide in the cattle industry. Lipoproteins, vital components of the Mycoplasmas cell membrane, are deemed potent antigens for eliciting immune responses in the host upon infection. However, the functions of lipoproteins in M. bovis remain underexplored due to their low sequence similarity with those of other bacteria and the scarcity of genetic manipulation tools for M...
November 17, 2023: Veterinary Research
https://read.qxmd.com/read/37962808/silencing-ahnak-promotes-nasopharyngeal-carcinoma-progression-by-upregulating-the-anxa2-protein
#28
JOURNAL ARTICLE
Xingxing Lu, Yan Mei, Chunmei Fan, Pan Chen, Xiayu Li, Zhaoyang Zeng, Guiyuan Li, Wei Xiong, Bo Xiang, Mei Yi
PURPOSE: Nasopharyngeal carcinoma (NPC) is an aggressive head and neck disease with a high incidence of distant metastases. Enlargeosomes are cytoplasmic organelles marked by, desmoyokin/AHNAK. This study aimed to evaluate the expression of AHNAK in NPC and its effect on enlargeosomes and to investigate the correlation between AHNAK expression levels and clinical NPC patient characteristics. METHODS: Primary nasopharyngeal carcinoma (NPC) and NPC specimens were evaluated by analyzing public data, and immunohistochemistry...
November 14, 2023: Cellular Oncology (Dordrecht)
https://read.qxmd.com/read/37955107/the-intricate-role-of-annexin-a2-in-kidney-a-comprehensive-review
#29
REVIEW
Juan Lei, Pingping Sun, Jingyi Sheng, Hongri Wang, Yifan Xie, Jiayu Song
Annexin A2 (Anxa2) is a calcium (Ca2+ )-regulated phospholipid binding protein composed of a variable N-terminus and a conserved core domain. This protein has been widely found in many tissues and fluids, including tubule cells, glomerular epithelial cells, renal vessels, and urine. In acute kidney injury, the expression level of this protein is markedly elevated in response to acute stress. Moreover, Anxa2 is a novel biomarker and potential therapeutic target with prognostic value in chronic kidney disease...
2023: Renal Failure
https://read.qxmd.com/read/37941562/collagen-i-influences-the-post-translational-regulation-binding-partners-and-role-of-annexin-a2-in-breast-cancer-progression
#30
JOURNAL ARTICLE
Amira F Mahdi, Joanne Nolan, Ruth Í O'Connor, Aoife J Lowery, Joanna M Allardyce, Patrick A Kiely, Kieran McGourty
INTRODUCTION: The extracellular matrix (ECM) has been heavily implicated in the development and progression of cancer. We have previously shown that Annexin A2 is integral in the migration and invasion of breast cancer cells and in the clinical progression of ER-negative breast cancer, processes which are highly influenced by the surrounding tumor microenvironment and ECM. METHODS: We investigated how modulations of the ECM may affect the role of Annexin A2 in MDA-MB-231 breast cancer cells using western blotting, immunofluorescent confocal microscopy and immuno-precipitation mass spectrometry techniques...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37901702/review-of-the-role-of-rituximab-in-the-management-of-adult-minimal-change-disease-and-immune-mediated-focal-and-segmental-glomerulosclerosis
#31
REVIEW
Ahsan Aslam, Abbal Koirala
BACKGROUND: Minimal change disease and primary FSGS are podocytopathies but are also immune-mediated diseases. Rituximab acts via multiple mechanisms by tilting the balance between autoreactive B and T cells in favor of regulatory B and T cells. The consequences are decreased production of cytokines, chemokines, and permeability factors by these cells. In the past decade, we have seen the discovery of autoantibodies mediating nephrotic syndrome (anti-annexin A2 antibody, anti-UCHL1 antibody, and anti-nephrin antibody), and rituximab decreases their production...
2023: Glomerular diseases
https://read.qxmd.com/read/37844241/accumulation-of-annexin-a2-and-s100a10-prevents-apoptosis-of-apically-delaminated-transformed-epithelial-cells
#32
JOURNAL ARTICLE
Shoko Ito, Keisuke Kuromiya, Miho Sekai, Hiroaki Sako, Kazuhito Sai, Riho Morikawa, Yohei Mukai, Yoko Ida, Moe Anzai, Susumu Ishikawa, Kei Kozawa, Takanobu Shirai, Nobuyuki Tanimura, Kenta Sugie, Junichi Ikenouchi, Motoyuki Ogawa, Isao Naguro, Hidenori Ichijo, Yasuyuki Fujita
In various epithelial tissues, the epithelial monolayer acts as a barrier. To fulfill its function, the structural integrity of the epithelium is tightly controlled. When normal epithelial cells detach from the basal substratum and delaminate into the apical lumen, the apically extruded cells undergo apoptosis, which is termed anoikis. In contrast, transformed cells often become resistant to anoikis and able to survive and grow in the apical luminal space, leading to the formation of multilayered structures, which can be observed at the early stage of carcinogenesis...
October 24, 2023: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/37834227/annexin-a2-stabilizes-oncogenic-jag1-intracellular-domain-by-inhibiting-proteasomal-degradation-in-glioblastoma-cells
#33
JOURNAL ARTICLE
Seok Won Ham, Jung Yun Kim, Sunyoung Seo, Nayoung Hong, Min Ji Park, Yoonji Kim, Junseok Jang, Sehyeon Park, Silvee Jisoo Lee, Jun-Kyum Kim, Eun-Jung Kim, Sung-Ok Kim, Sung-Chan Kim, Jong-Whi Park, Hyunggee Kim
Glioblastoma (GBM) is the most lethal brain cancer, causing inevitable deaths of patients owing to frequent relapses of cancer stem cells (CSCs). The significance of the NOTCH signaling pathway in CSCs has been well recognized; however, there is no NOTCH-selective treatment applicable to patients with GBM. We recently reported that Jagged1 (JAG1), a NOTCH ligand, drives a NOTCH receptor-independent signaling pathway via JAG1 intracellular domain (JICD1) as a crucial signal that renders CSC properties. Therefore, mechanisms regulating the JICD1 signaling pathway should be elucidated to further develop a selective therapeutic regimen...
September 30, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37832154/annexin-a2-facilitates-neovascularization-to-protect-against-myocardial-infarction-injury-via-interacting-with-macrophage-yap-and-endothelial-integrin-%C3%AE-3
#34
JOURNAL ARTICLE
Yu Zhang, Yan Wang, Jiao Li, Chaofu Li, Weiwei Liu, Xianping Long, Zhenglong Wang, Ranzun Zhao, Junbo Ge, Bei Shi
Cardiac macrophages with different polarization phenotypes regulate ventricular remodeling and neovascularization after myocardial infarction (MI). Annexin A2 (ANXA2) promotes macrophage polarization to the repair phenotype and regulates neovascularization. However, whether ANXA2 plays any role in post-MI remodeling and its underlying mechanism remains obscure. In this study, we observed that expression levels of ANXA2 were dynamically altered in mouse hearts upon MI and peaked on the second day post-MI. Using adeno-associated virus vector-mediated overexpression or silencing of ANXA2 in the heart, we also found that elevation of ANXA2 in the infarcted myocardium significantly improved cardiac function, reduced cardiac fibrosis, and promoted peri-infarct angiogenesis, compared with controls...
October 1, 2023: Shock
https://read.qxmd.com/read/37828081/a-de-novo-missense-mutation-in-mpp2-confers-an-increased-risk-of-vogt-koyanagi-harada-disease-as-shown-by-trio-based-whole-exome-sequencing
#35
JOURNAL ARTICLE
Xianyang Liu, Jiayu Meng, Xingyun Liao, Yusen Liu, Qian Zhou, Zongren Xu, Shuming Yin, Qingfeng Cao, Guannan Su, Siyuan He, Wanqian Li, Xiaotang Wang, Guoqing Wang, Dali Li, Peizeng Yang, Shengping Hou
Vogt-Koyanagi-Harada (VKH) disease is a leading cause of blindness in young and middle-aged people. However, the etiology of VKH disease remains unclear. Here, we performed the first trio-based whole-exome sequencing study, which enrolled 25 VKH patients and 50 controls, followed by a study of 2081 VKH patients from a Han Chinese population to uncover detrimental mutations. A total of 15 de novo mutations in VKH patients were identified, with one of the most important being the membrane palmitoylated protein 2 (MPP2) p...
October 12, 2023: Cellular & Molecular Immunology
https://read.qxmd.com/read/37782406/fgf19-promotes-nasopharyngeal-carcinoma-progression-by-inducing-angiogenesis-via-inhibiting-trim21-mediated-anxa2-ubiquitination
#36
JOURNAL ARTICLE
Si Shi, Qicheng Zhang, Kaiwen Zhang, Wenhui Chen, Haijing Xie, Si Pan, Ziyi Xue, Bo You, Jianmei Zhao, Yiwen You
PURPOSE: Nasopharyngeal carcinoma (NPC) has characteristics of high invasion and early metastasis. Most NPC patients present with locoregionally advanced illness when first diagnosed. Therefore, it is urgent to discover NPC biomarkers. Fibroblast growth Factor 19 (FGF19) plays a role in various physiological or pathological processes, including cancer. In this research, we discovered the importance of FGF19 in NPC, and clarified its role in tumour angiogenesis. METHODS: Western blotting, immunohistochemistry and ELISA were used to investigate FGF19 expression in NPC...
October 2, 2023: Cellular Oncology (Dordrecht)
https://read.qxmd.com/read/37755639/chemical-hypoxic-preconditioning-improves-survival-and-proliferation-of-mesenchymal-stem-cells
#37
JOURNAL ARTICLE
Kanwal Haneef, Asmat Salim, Zehra Hashim, Amber Ilyas, Basir Syed, Aftab Ahmed, Shamshad Zarina
Increasing evidence has demonstrated that mesenchymal stem cells (MSCs) have been linked to tissue regeneration both in vitro and in vivo. However, poor engraftment and low survival rate of transplanted MSCs are still a major concern. It has been found that the proliferation, survival, and migration of MSCs are all increased by hypoxic preconditioning. However, the molecular mechanism through which hypoxic preconditioning enhances these beneficial properties of MSCs remains to be fully investigated. Therefore, the present study is aimed to investigate the mechanism by which hypoxic preconditioning enhances the survival of MSCs...
September 27, 2023: Applied Biochemistry and Biotechnology
https://read.qxmd.com/read/37753171/urine-proteomic-analysis-of-the-rat-e-cigarette-model
#38
JOURNAL ARTICLE
Yuqing Liu, Ziyun Shen, Chenyang Zhao, Youhe Gao
BACKGROUND: We were curious if the urinary proteome could reflect the effects of e-cigarettes on the organism. METHODS: Urine samples were collected from a rat e-cigarette model before, during, and after two weeks of e-cigarette smoking. Urine proteomes before and after smoking of each rat were compared individually, while the control group was set up to rule out differences caused by rat growth and development. RESULTS: Fetuin-B, a biomarker of chronic obstructive pulmonary disease (COPD), and annexin A2, which is recognized as a multiple tumour marker, were identified as differential proteins in five out of six smoking rats on day 3...
2023: PeerJ
https://read.qxmd.com/read/37740172/analysis-of-differential-membrane-proteins-related-to-matrix-stiffness-mediated-metformin-resistance-in-hepatocellular-carcinoma-cells
#39
JOURNAL ARTICLE
Xiangyu Gao, Jiali Qian, Yang Zhang, Heming Wang, Jiefeng Cui, Yehong Yang
BACKGROUND: Our previous work shows that increased matrix stiffness not only alters malignant characteristics of hepatocellular carcinoma (HCC) cells, but also attenuates metformin efficacy in treating HCC cells. Here, we identified differential membrane proteins related to matrix stiffness-mediated metformin resistance for better understand therapeutic resistance of metformin in HCC. METHODS: Differential membrane proteins in HCC cells grown on different stiffness substrates before and after metformin intervention were screened and identified using isobaric tags for relative and absolute quantification (iTRAQ) labeling coupled with the liquid chromatography-tandem mass spectrometry (LC-MS/MS), then bioinformatic analysis were applied to determine candidate membrane protein and their possible signaling pathway...
September 22, 2023: Proteome Science
https://read.qxmd.com/read/37714253/upregulation-of-epha2-is-associated-with-apoptosis-in-response-to-h-2-o-2-and-uv-radiation-induced-cataracts
#40
JOURNAL ARTICLE
Wei Zhao, Shuying Chen, Bing Lu, Di Wu, Yuzhou Gu, Shengjie Hao, Feiyin Sheng, Yili Xu, Yu Han, Rongrong Chen, Lei Zhou, Qiuli Fu, Ke Yao
In this article, we examine the role of erythropoietin-producing hepatocellular receptor A2 (EphA2) in the apoptosis of lens epithelial cells (LECs) in H2 O2 and UV radiation-induced cataracts. We treated SRA01/04 cells with H2 O2 or ultraviolet (UV) radiation to create a cataract cell model. We constructed a cataract lens model by exposing mice to UV radiation. We used CCK8 assays, Annexin V-FITC analysis, and immunohistochemical staining to explore proliferation and apoptosis of the cataract model. Thereafter, we used quantitative real-time PCR (qPCR) analysis, Western blot assays, and immunofluorescence to determine gene and protein expression levels...
October 1, 2023: Archives of Biochemistry and Biophysics
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