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annexin A2

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https://www.readbyqxmd.com/read/29152144/tissue-type-plasminogen-activator-modulates-macrophage-m2-to-m1-phenotypic-change-through-annexin-a2-mediated-nf-%C3%AE%C2%BAb-pathway
#1
Ling Lin, Kebin Hu
Macrophage accumulation is one of the hallmarks of progressive kidney disease. In response to injury, macrophages undergo a phenotypic polarization to become two functionally distinct subsets: M1 and M2 macrophages. Macrophage polarization is a dynamic process, and recent work indicates that macrophages, in response to kidney injury, can shift their polarity. However, the underlying mechanisms remain largely unknown. Tissue-type plasminogen activator (tPA), a protease up-regulated in the chronically injured kidneys, has been shown to preferably promote M1 macrophage accumulation and renal inflammation...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29115416/annexin-a2-and-cancer-a-systematic-review
#2
Maria V Christensen, Claus K Høgdall, Kirsten M Jochumsen, Estrid V S Høgdall
Annexin A2 is a 36-kDa protein interfering with multiple cellular processes especially in cancer progression. The present review aimed to show the relations between Annexin A2 and cancer. A systematic search for studies investigating cancer and Annexin A2 expression was conducted using PubMed. Acute lymphoblastic leukaemia, acute promyelocytic leukaemia, clear cell renal cell carcinoma, breast, cervical, colorectal, endometrial, gastric cancer, glioblastoma, hepatocellular carcinoma, lung, multiple myeloma, oesophageal squamous cell carcinoma, ovarian cancer, pancreatic duct adenocarcinoma, prostate cancer and urothelial carcinoma were evaluated...
November 8, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29044433/pregnancy-induced-changes-in-metabolome-and-proteome-in-ovine-uterine-flushings
#3
Jared J Romero, Bethany E Liebig, Corey D Broeckling, Jessica E Prenni, Thomas R Hansen
Mass spectrometry (MS) approaches were used herein to identify metabolites and proteins in uterine flushings (UF) that may contribute to nourishing the conceptus. Ovine uteri collected on Day 12 of the estrous cycle (n = 5 ewes exposed to vasectomized ram) or Days 12 (n = 4), 14 (n = 5), or 16 (n = 5) of pregnancy (bred with fertile ram) were flushed using buffered saline. Metabolites were extracted using 80% methanol and profiled using ultraperformance liquid chromatography (LC) tandem mass spectrometry. The proteome was examined by digestion with trypsin, followed by the analysis of peptides with LC-MS/MS...
August 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29030970/annexin-a1-annexin-a2-and-dyrk-1b-are-upregulated-during-gas1-induced-cell-cycle-arrest
#4
G Pérez-Sánchez, A Jiménez, M A Quezada-Ramírez, E Estudillo, A E Ayala-Sarmiento, G Mendoza-Hernández, Justino Hernández-Soto, F C Hernández-Hernández, F E Cázares-Raga, J Segovia
GAS1 is a pleiotropic protein that has been investigated because of its ability to induce cell proliferation, cell arrest, and apoptosis, depending on the cellular or the physiological context in which it is expressed. At this point, we have information about the molecular mechanisms by which GAS1 induces proliferation and apoptosis; but very few studies have been focused on elucidating the mechanisms by which GAS1 induces cell arrest. With the aim of expanding our knowledge on this subject, we first focused our research on finding proteins that were preferentially expressed in cells arrested by serum deprivation...
October 14, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28989535/investigating-the-microrna-mrna-regulatory-network-in-acute-myeloid-leukemia
#5
Haiguo Zhang, Chengfang Zhang, Rui Feng, Haixia Zhang, Min Gao, Ling Ye
Acute myeloid leukemia (AML) is a common myelogenous malignancy in adults that is often characterized by disease relapse. The pathophysiological mechanism of AML has not yet been elucidated. The present study aimed to identify the crucial microRNAs (miRNAs/miRs) and target genes in AML, and to uncover the potential oncogenic mechanism of AML. miRNA and mRNA expression-profiling microarray datasets were downloaded from the Gene Expression Omnibus database. Differential expression analysis was performed and a regulatory network between miRNAs and target genes was constructed...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28979207/3-mercaptopyruvate-sulfurtransferase-not-cystathionine-%C3%AE-synthase-nor-cystathionine-%C3%AE-lyase-mediates-hypoxia-induced-migration-of-vascular-endothelial-cells
#6
Beibei Tao, Rui Wang, Chen Sun, Yichun Zhu
Hypoxia-induced angiogenesis is a common phenomenon in many physiological and patho-physiological processes. However, the potential differential roles of three hydrogen sulfide producing systems cystathionine γ-lyase (CSE)/H2S, cystathionine β-synthase (CBS)/H2S, and 3-mercaptopyruvate sulfurtransferase (MPST)/H2S in hypoxia-induced angiogenesis are still unknown. We found that minor hypoxia (10% oxygen) significantly increased the migration of vascular endothelial cells while hypoxia (8% oxygen) significantly inhibited cell migration...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28976984/mycoplasma-associated-multidrug-resistance-of-hepatocarcinoma-cells-requires-the-interaction-of-p37-and-annexin-a2
#7
Danyang Liu, Yang Hu, Ying Guo, Zhu Zhu, Bingzheng Lu, Xuelan Wang, Yijun Huang
Mycoplasma infection has been reported to be associated with cancer migration, invasion, epithelial-mesenchymal transition as well as the resistance to nucleoside analogues chemotherapeutic drugs. In this study, we found that the sensitivity of hepatocarcinoma cells to Cisplatin, Gemcitabine and Mitoxantrone was increased by mycoplasma elimination. Similar to the effect of anti-mycoplasma agent, interrupting the interaction between Mycoplasma hyorhinis membrane protein P37 and Annexin A2 of host cells using the N-terminal of ANXA2 polypeptide enhanced the sensitivity of HCC97L cells to Gemcitabine and Mitoxantrone...
2017: PloS One
https://www.readbyqxmd.com/read/28967196/tetrazole-based-probes-for-integrated-phenotypic-screening-affinity-based-proteome-profiling-and-sensitive-detection-of-a-cancer-biomarker
#8
Ke Cheng, Jun-Seok Lee, Piliang Hao, Shao Q Yao, Ke Ding, Zhengqiu Li
Target-identification phenotypic screening has been a powerful approach in drug discovery; however, it is hindered by difficulties in identifying the underlying cellular targets. To address this challenge, we have combined phenotypic screening of a fully functionalized small-molecule library with competitive affinity-based proteome profiling to map and functionally characterize the targets of screening hits. Using this approach, we identified ANXA2, PDIA3/4, FLAD1, and NOS2 as primary cellular targets of two bioactive molecules that inhibit cancer cell proliferation...
October 1, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28963461/the-identification-of-molecular-target-of-20s-ginsenoside-rh2-for-its-anti-cancer-activity
#9
Yu-Shi Wang, Yingjia Lin, He Li, Yang Li, Zhiguang Song, Ying-Hua Jin
The 20S ginsenoside Rh2 (G-Rh2) effectively inhibits cancer cell growth and survival in both animal models and cell lines. However, its molecular targets and mechanism of action remain largely unknown. By screening for molecules that interact with (20S)G-Rh2 in a phage display assay, we have identified Annexin A2 as a potential target that mediates its anti-cancer activity. Isothermal titration calorimetry and a cellular thermal shift assay demonstrated that (20S)G-Rh2 directly bound to either recombinant or intracellular Annexin A2...
September 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28963375/expression-correlates-between-annexin-a1-and-a2-autoantibodies-in-patients-with-behcet-s-disease
#10
Muhammad Hussain, Peng Chen, Guang Mei, Yongzhe Li, Hongwu Du
The autoantibodies profile of Behcet's disease (BD) is yet incompletely understood. Annexins are a family of highly conserved proteins which are involved in some human autoimmune diseases. Autoantibodies directed toward Annexin A1 and A2 are involved in BD pathology, but correlation in their clinical role is controversial.Our study aim is to estimate and evaluate the expression correlation between Annexin A1 and A2 autoantibodies in BD patients. We have designed and implemented different technical approaches to prove the hypothesis...
September 29, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28956004/protease-activity-of-legumain-is-inhibited-by-an-increase-of-cystatin-e-m-in-the-dj-1-knockout-mouse-spleen-cerebrum-and-heart
#11
Takuya Yamane, Miyuki Kozuka, Yoshio Yamamoto, Yoshihisa Nakano, Takenori Nakagaki, Iwao Ohkubo, Hiroyoshi Ariga
Legumain (EC 3.4.22.34) is an asparaginyl endopeptidase. Legumain activity has been detected in various mouse tissues including the kidney, spleen and epididymis. Legumain is overexpressed in the majority of human solid tumors and transcription of the legumain gene is regulated by the p53 tumor suppressor in HCT116 cells. The legumain activity is also increased under acid conditions in Alzheimer's disease brains. DJ-1/PARK7, a cancer- and Parkinson's disease-associated protein, works as a coactivator to various transcription factors, including the androgen receptor, p53, PSF, Nrf2, SREBP and RREB1...
March 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28947421/mesenchymal-stem-cells-promote-hepatocarcinogenesis-via-lncrna-muf-interaction-with-anxa2-and-mir-34a
#12
Xinlong Yan, Dongdong Zhang, Wei Wu, Shuheng Wu, Jingfeng Qian, Yajing Hao, Fang Yan, Pingping Zhu, Jiayi Wu, Guanling Huang, Yinghui Huang, Jianjun Luo, Xinhui Liu, Benyu Liu, Xiaomin Chen, Ying Du, Run-Sheng Chen, Zusen Fan
Accumulating evidence suggests that cancer-associated mesenchymal stem cells (MSC) contribute to the development and metastasis of hepatocellular carcinoma (HCC). Aberrant expression of long noncoding RNAs (lncRNA) has been associated with these processes but cellular mechanisms are obscure. In this study, we report that HCC-associated mesenchymal stem cells (HCC-MSC) promote epithelial-mesenchymal transition (EMT) and liver tumorigenesis. We identified a novel lncRNA that we termed lncRNA-MUF (MSC upregulated factor) that is highly expressed in HCC tissues and correlated with poor prognosis...
September 25, 2017: Cancer Research
https://www.readbyqxmd.com/read/28943905/screening-the-key-genes-of-hepatocellular-adenoma-via-microarray-analysis-of-dna-expression-and-methylation-profiles
#13
Dan Liu, Pengfei Liu, Liye Cao, Quan Zhang, Yaqing Chen
The aim of the present study was to identify the biomarkers involved in the development of hepatocellular adenoma (HCA) through integrated analysis of gene expression and methylation microarray. The microarray dataset GSE7473, containing HNF1α-mutated HCA and their corresponding non-tumor livers, 5 HNF1α-mutated HCA and 4 non-related non-tumor livers, was downloaded from the Gene Expression Omnibus (GEO) database. The DNA methylation profile GSE43091, consisting of 50 HCA and 4 normal liver tissues, was also downloaded from the GEO database...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943392/an-integrative-analysis-of-chemically-induced-cirrhosis-associated-hepatocarcinogenesis-histological-biochemical-and-molecular-features
#14
Guilherme Ribeiro Romualdo, Tony Fernando Grassi, Renata Leme Goto, Mariana Baptista Tablas, Lucas Tadeu Bidinotto, Ana Angélica Henrique Fernandes, Bruno Cogliati, Luís Fernando Barbisan
This study aimed the integrative characterization of morphological, biochemical and molecular features of chemically-induced cirrhosis-associated hepatocarcinogenesis. Thus, male Wistar rats were submitted to a diethylnitrosamine (DEN)/thioacetamide (TAA)-induced model. Liver tissue was processed for global gene expression, histopathological and collagen evaluations; as well as immunohistochemical and oxidative stress analysis. Gene Ontology and functional analysis showed the upregulation of extracellular matrix deposition genes, such as collagen type I alpha 1 and 2 (Col1α1 and Col1α2) and tissue inhibitor of metalloproteinase 1 and 2 genes (Timp1 and Timp2)...
November 5, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28937994/modeling-of-annexin-a2-membrane-interactions-by-molecular-dynamics-simulations
#15
Davit Hakobyan, Volker Gerke, Andreas Heuer
The annexins are a family of Ca2+-regulated phospholipid binding proteins that are involved in membrane domain organization and membrane trafficking. Although they are widely studied and crystal structures are available for several soluble annexins their mode of membrane association has never been studied at the molecular level. Here we obtained molecular information on the annexin-membrane interaction that could serve as paradigm for the peripheral membrane association of cytosolic proteins by Molecular Dynamics simulations...
2017: PloS One
https://www.readbyqxmd.com/read/28927158/regulation-of-htra2-on-wt1-gene-expression-under-imatinib-stimulation-and-its-effects-on-the-cell-biology-of-k562-cells
#16
Lixia Zhang, Yan Li, Xiaoyan Li, Qing Zhang, Shaowei Qiu, Qi Zhang, Min Wang, Haiyan Xing, Qing Rao, Zheng Tian, Kejing Tang, Jianxiang Wang, Yingchang Mi
The aim of the present study was to investigate the regulation of Wilms Tumor 1 (WT1) by serine protease high-temperature requirement protein A2 (HtrA2), a member of the Htr family, in K562 cells. In addition, the study aimed to observe the effect of this regulation on cell biological functions and its associated mechanisms. Expression of WT1 and HtrA2 mRNA, and proteins following imatinib and the HtrA2 inhibitor 5-[5-(2-nitrophenyl) furfuryl iodine]-1, 3-diphenyl-2-thiobarbituric acid (UCF-101) treatment was detected with reverse transcription-quantitative polymerase chain reaction and western blot analysis...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28893180/annexin-a2-anxa2-interacts-with-nonstructural-protein-1-and-promotes-the-replication-of-highly-pathogenic-h5n1-avian-influenza-virus
#17
Yong Ma, Jiashan Sun, Linlin Gu, Hongmei Bao, Yuhui Zhao, Lin Shi, Wei Yao, Guobin Tian, Xiurong Wang, Hualan Chen
BACKGROUND: Non-structural protein 1 (NS1) is a multifunctional protein and a crucial regulatory factor in the replication and pathogenesis of avian influenza virus (AIV). Studies have shown that NS1 can interact with a variety of host proteins to modulate the viral life cycle. We previously generated a monoclonal antibody against NS1 protein; In the current research study, using this antibody, we immunoprecipitated host proteins that interact with NS1 to better understand the roles played by NS1 in communications between virus and host...
September 11, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28886987/consequences-of-the-natural-retinoid-retinoid-x-receptor-ligands-action-in-human-breast-cancer-mda-mb-231-cell-line-focus-on-functional-proteomics
#18
D Flodrova, L Toporova, M Lastovickova, D Macejova, L Hunakova, J Brtko, J Bobalova
The main intention of this study was the investigation of impact of natural biologically active ligands of nuclear retinoid/retinoid X receptors (all-trans and 9-cis retinoic acid) on proteomic pattern in human estrogen receptor negative breast cancer cell line MDA-MB-231. For this purpose, proteomic strategies based on bottom-up method were applied. The total cell proteins were extracted utilizing a commercially Radio-Immunoprecipitation Assay (RIPA) buffer and separated on 2D sodium dodecyl sulfate polyacrylamide gel electrophoresis (2D SDS-PAGE)...
November 5, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28886730/annexin-a2-contributes-to-cisplatin-resistance-by-activation-of-jnk-p53-pathway-in-non-small-cell-lung-cancer-cells
#19
Xiaomin Feng, Hao Liu, Zhijie Zhang, Yixue Gu, Huisi Qiu, Zhimin He
BACKGROUND: Development of resistance to therapy continues to be a serious clinical problem in lung cancer management. We previously identified that Annexin A2 is significantly up-regulated in cisplatin-resistant non-small cell lung cancer (NSCLC) A549/DDP cells. However, the exact function and molecular mechanism of Annexin A2 in cisplatin resistance of NSCLCs has not been determined. METHODS: Western blot and qRT-PCR were performed to analyze the protein and mRNA level of indicated molecules, respectively...
September 8, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/28867585/protein-phosphorylation-and-its-role-in-the-regulation-of-annexin-a2-function
#20
REVIEW
Ann Kari Grindheim, Jaakko Saraste, Anni Vedeler
BACKGROUND: Annexin A2 (AnxA2) is a multifunctional protein involved in endocytosis, exocytosis, membrane domain organisation, actin remodelling, signal transduction, protein assembly, transcription and mRNA transport, as well as DNA replication and repair. SCOPE OF REVIEW: The current knowledge of the role of phosphorylation in the functional regulation of AnxA2 is reviewed. To provide a more comprehensive treatment of this topic, we also address in depth the phosphorylation process in general and discuss its possible conformational effects...
November 2017: Biochimica et Biophysica Acta
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