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annexin A2

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https://www.readbyqxmd.com/read/29342010/the-ever-expanding-saga-of-the-proprotein-convertases-and-their-roles-in-body-homeostasis-emphasis-on-novel-proprotein-convertase-subtilisin-kexin-number-9-functions-and-regulation
#1
Nabil G Seidah, Michel Chrétien, Majambu Mbikay
PURPOSE OF REVIEW: The nine members of the proprotein convertase family play major physiological roles during development and in the adult, and their dysregulation leads to various diseases. The primary objective of this article is to review recent findings on the clinical importance of some of these convertases concentrating mostly on PCSK9, the ninth member of the convertase family. This includes the transcriptional and translational regulation of PCSK9, its ability to enhance the degradation of LDL receptor (LDLR), and the implication of PCSK9 in inflammation and sepsis...
January 15, 2018: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/29332450/identification-and-comparison-of-differentiation-related-proteins-in-hepatocellular-carcinoma-tissues-by-proteomics
#2
Sheng Zhao, Gang Su, Wenke Yang, Ping Yue, Bing Bai, Yanyan Lin, Jinduo Zhang, Yongjiang Ba, Zhiwen Luo, Xiaoming Liu, Lili Zhao, Yi Xie, Yaowei Xu, Shuo Li, Wenbo Meng, Xiaodong Xie, Xun Li
Histological differentiation is a major pathological criterion indicating the risk of tumor invasion and metastasis in patients with hepatocellular carcinoma. The degree of tumor differentiation is controlled by a complex interacting network of associated proteins. The principal aim of the present study is to identify the possible differentiation-related proteins which may be used for early diagnosis and more effective therapies. We compared poorly differentiated and well-differentiated hepatocellular carcinoma tissues by using 2-dimensional gel electrophoresis and matrix-assisted laser desorption ionization time-of-flight mass spectrometry...
December 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29328466/knockdown-of-immature-colon-carcinoma-transcript%C3%A2-1-induces-suppression-of-proliferation-s-phase-arrest-and-apoptosis-in-leukemia-cells
#3
Guang-Yao Li, Ji-Zhu Liu, Li Zhang, Guo-Zhen Liu, Shuang-Jing Li, Tai-Wu Xiao, Jing-Xia Wang, Le-Xin Wang, Ming Hou
Immature colon carcinoma transcript 1 (ICT1), a human mitochondrial translation release factor, is a ribosome-dependent codon-independent peptidyl-tRNA hydrolase. ICT1-deficiency has been recognized as a cell growth inhibitor of hepatoblastoma and glioblastoma multiforme. To explore the role of ICT1 in human leukemia, 2 short hairpin RNAs (shRNAs) targeting ICT1 sequences were designed in leukemia U937 cells. The successful infection of ICT1 in the U937 cells was observed under a fluorescence microscope and further quantified by western blotting and quantitative real-time PCR (qRT-PCR) analysis...
January 3, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29326439/lung-fibroblasts-promote-metastatic-colonization-through-upregulation-of-stearoyl-coa-desaturase-1-in-tumor-cells
#4
Guanghua Liu, Shi Feng, Lin Jia, Chunying Wang, Yan Fu, Yongzhang Luo
As a rate-limiting step in metastasis, metastatic colonization requires survival signals from supportive stroma. However, the mechanisms driving this process are incompletely understood. Here, we showed that the proliferation of B16F10 cells was promoted when cocultured with lung fibroblasts. Meanwhile, co-injection of B16F10 tumor cells with mouse lung fibroblasts significantly increased lung metastasis. Based on GEO database, we identified stearoyl-CoA desaturase 1 (SCD1) as a novel factor promoting metastatic colonization...
January 12, 2018: Oncogene
https://www.readbyqxmd.com/read/29323127/differential-proteomics-of-lesional-vs-non-lesional-biopsies-revealed-non-immune-mechanisms-of-alopecia-areata
#5
Kanchalit Thanomkitti, Rattiyaporn Kanlaya, Kedsarin Fong-Ngern, Chompunoot Kapincharanon, Kanyarat Sueksakit, Prangwalai Chanchaem, Rattapon Thuangtong, Visith Thongboonkerd
Alopecia areata (AA) is one of the common hair disorders for which treatment is frequently ineffective and associated with relapsing episodes. Better understanding of disease mechanisms and novel therapeutic targets are thus required. From 10 AA patients, quantitative proteomics using LTQ-Orbitrap-XL mass spectrometer revealed 104 down-regulated, 4 absent, 3 up-regulated and 11 newly present proteins in lesional vs. non-lesional biopsies. Among these, the decreased levels of α-tubulin, vimentin, heat shock protein 70 (HSP70), HSP90, annexin A2 and α-enolase were successfully confirmed by Western blotting...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29291003/pseudogenes-of-annexin-a2-novel-prognosis-biomarkers-for-diffuse-gliomas
#6
Shuang Li, Hecun Zou, Ying-Ying Shao, Ying Mei, Yu Cheng, Dong-Li Hu, Zhi-Rong Tan, Hong-Hao Zhou
Diffuse gliomas is a kind of common malignant primary brain tumor. Pseudogenes have multilayered biological function in the progression of human cancers. In this study, Differentially Expressed Pseudogenes (DEPs) between glioblastomas and non-tumor controls were found by bioinformatics analysis, of which the annexin A2 pseudogenes (ANXA2P1, ANXA2P2 and ANXA2P3) were significantly up-regulated, along with the parent gene annexin A2 (ANXA2). Among four glioblastoma subtypes, ANXA2P1 and ANXA2P2 were preferentially expressed in mesenchymal subtype and less expressed in proneural subtype...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29290958/stromal-annexin-a2-expression-is-predictive-of-decreased-survival-in-pancreatic-cancer
#7
Adrian G Murphy, Kelly Foley, Agnieszka A Rucki, Tao Xia, Elizabeth M Jaffee, Chiung-Yu Huang, Lei Zheng
Pancreatic ductal adenocarcinoma (PDA) is renowned for high rates of metastasis and poor survival. Its notoriously dense fibrotic stroma contributes to chemoresistance. Stromal signaling in PDA is recognized for its multiple roles in regulating tumor invasion and metastasis. However, no stromal biomarker which can predict survival in PDA exists. Annexin A2 (AnxA2) was formerly identified as a metastasis-associated protein in PDA and tumoral overexpression is associated with poor survival. In this study, we examined AnxA2 expression in the tumor microenvironment in a preclinical model of PDA which suggests its role in tumor colonization...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29285166/annexin-a2-is-an-independent-prognostic-biomarker-for-evaluating-the-malignant-progression-of-laryngeal-cancer
#8
Shi Luo, Chubo Xie, Ping Wu, Jian He, Yaoyun Tang, Jing Xu, Suping Zhao
Due to the lack of a definite diagnosis, a frequent recurrence rate and resistance to chemotherapy or radiotherapy, the clinical outcome for patients with advanced laryngeal cancer has not improved over the last decade. Annexin A2 is associated with the invasion and metastasis of cancer cells. In the present study, it was demonstrated using differential proteomics analysis that Annexin A2 is highly expressed in laryngeal carcinoma tissues and this was confirmed using immunohistochemistry, which demonstrated that the expression of Annexin A2 in laryngeal carcinoma tissues was significantly higher than in healthy adjacent tissue...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29251320/mechanism-of-endogenous-digitalis-like-factor%C3%A2-induced-vascular-endothelial-cell-damage-in-patients-with-severe-preeclampsia
#9
Mei Peng, Mengyuan Yang, Yiling Ding, Ling Yu, Yali Deng, Weisi Lai, Yun Hu
Although endogenous digitalis‑like factor (EDLF) is associated with the development of various physical disorders, the role in preeclampsia remains unclear. This study investigated the effects of EDLF on vascular endothelial cell damage in patients with preeclampsia and the potential mechanisms. From July 2014 to July 2015, 120 singleton pregnancy cases underwent a prenatal examination, inpatient delivery and had normal blood pressure were included in the study, either as patients with severe preeclampsia or the control patients...
February 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29240248/sperm-binding-to-porcine-oviductal-cells-is-mediated-by-srcr-domains-contained-in-dmbt1
#10
María Lorena Roldán, Juan Manuel Teijeiro, Jimena Ruiz Álvarez, Patricia Estela Marini
The oviduct is an organ in which a subpopulation of sperm is stored in a reservoir, preserving its fertilizing potential. In porcine, two oviductal proteins have been identified in relation to sperm binding, Annexin A2 and Deleted in Malignant Brain Tumour 1 (DMBT1). DMBT1 is a multifunctional, multidomain glycoprotein and the characteristics of all of its domains, as well as its carbohydrates, make them candidates for sperm binding. In this work, we challenge sperm for binding to pig oviductal cells on primary culture, after treatment with antibodies specific for the different domains present in DMBT1...
December 14, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29234088/tear-proteome-analysis-in-ocular-surface-diseases-using-label-free-lc-ms-ms-and-multiplexed-microarray-biomarker-validation
#11
Javier Soria, Arantxa Acera, Jesús Merayo-LLoves, Juan A Durán, Nerea González, Sandra Rodriguez, Nikitas Bistolas, Soeren Schumacher, Frank F Bier, Harald Peter, Walter Stöcklein, Tatiana Suárez
We analyzed the tear film proteome of patients with dry eye (DE), meibomian gland dysfunction (MGD), and normal volunteers (CT). Tear samples were collected from 70 individuals. Of these, 37 samples were analyzed using spectral-counting-based LC-MS/MS label-free quantitation, and 33 samples were evaluated in the validation of candidate biomarkers employing customized antibody microarray assays. Comparative analysis of tear protein profiles revealed differences in the expression levels of 26 proteins, including protein S100A6, annexin A1, cystatin-S, thioredoxin, phospholipase A2, antileukoproteinase, and lactoperoxidase...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29228983/characterization-of-interactions-between-hepatitis-c-virus-ns5b-polymerase-annexin-a2-and-rna-effects-on-ns5b-catalysis-and-allosteric-inhibition
#12
Sara M Ø Solbak, Eldar Abdurakhmanov, Anni Vedeler, U Helena Danielson
BACKGROUND: Direct acting antivirals (DAAs) provide efficient hepatitis C virus (HCV) therapy and clearance for a majority of patients, but are not available or effective for all patients. They risk developing HCV-induced hepatocellular carcinoma (HCC), for which the mechanism remains obscure and therapy is missing. Annexin A2 (AnxA2) has been reported to co-precipitate with the non-structural (NS) HCV proteins NS5B and NS3/NS4A, indicating a role in HCC tumorigenesis and effect on DAA therapy...
December 11, 2017: Virology Journal
https://www.readbyqxmd.com/read/29217666/epac1-regulates-endothelial-annexin-a2-cell-surface-translocation-and-plasminogen-activation
#13
Wenli Yang, Fang C Mei, Xiaodong Cheng
Annexins, a family of highly conserved calcium- and phospholipid-binding proteins, play important roles in a wide range of physiologic functions. Among the 12 known annexins in humans, annexin A2 (AnxA2) is one of the most extensively studied and has been implicated in various human diseases. AnxA2 can exist as a monomer or a heterotetrameric complex with S100A10 (P11) and plays a critical role in many cellular processes, including exocytosis, endocytosis, and membrane organization. At the endothelial cell surface, the (AnxA2·P11)2 tetramer-acting as a coreceptor for plasminogen and tissue plasminogen activator (tPA)-accelerates tPA-dependent activation of the fibrinolytic protease, plasmin, the enzyme that is responsible for thrombus dissolution and the degradation of fibrin...
December 7, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29211704/histone-deacetylase-hdac-inhibitor-suberoylanilide-hydroxamic-acid-saha-induces-apoptosis-in-prostate-cancer-cell-lines-via-the-akt-foxo3a-signaling-pathway
#14
Xuan-Yan Shi, Wei Ding, Tie-Qiu Li, Yi-Xiong Zhang, Shan-Chao Zhao
BACKGROUND Histone deacetylase (HDAC) inhibitors are emerging as a new class of anti-cancer drugs that promote cancer cell apoptosis, and include suberoylanilide hydroxamic acid (SAHA). The aim of this study was to investigate the mechanism of SAHA-induced apoptosis in human prostate cancer cell lines, DU145 and PC-3. MATERIAL AND METHODS Cell lines, DU145 and PC-3, were studied before and after treatment with SAHA. The effects of SAHA treatment on cell proliferation were studied using the MTT cell proliferation assay...
December 6, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29187477/proteins-annexin-a2-and-psa-in-prostate-cancer-biopsies-do-not-predict-biochemical-failure
#15
David S Lamb, Sven Sondhauss, Jonathan C Dunne, Lisa Woods, Brett Delahunt, Peter Ferguson, Judith Murray, John N Nacey, James W Denham, T William Jordan
BACKGROUND/AIM: We previously reported the use of mass spectrometry and western blotting to identify proteins from tumour regions of formalin-fixed paraffin-embedded biopsies from 16 men who presented with apparently localized prostate cancer, and found that annexin A2 (ANXA2) appeared to be a better predictor of subsequent biochemical failure than prostate-specific antigen (PSA). MATERIALS AND METHODS: In this follow-up study, ANXA2 and PSA were measured using western blotting of proteins extracted from biopsies from 37 men from a subsequent prostate cancer trial...
December 2017: Anticancer Research
https://www.readbyqxmd.com/read/29185643/effects-of-insulin-intervention-on-the-expression-of-ve-cadherin-%C3%AE-catenin-annexin-a2-annexin-a5-and-14-3-3-protein-in-the-placentas-of-patients-with-gestational-diabetes-mellitus
#16
Jialin Su, Liting Yang, Weizhong Chen, Lisheng Liu, Yaoming Xue
No abstract text is available yet for this article.
November 28, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/29172997/identification-of-anxa2-annexin-a2-as-a-specific-bleomycin-target-to-induce-pulmonary-fibrosis-by-impeding-tfeb-mediated-autophagic-flux
#17
Kui Wang, Tao Zhang, Yunlong Lei, Xuefeng Li, Jingwen Jiang, Jiang Lan, Yuan Liu, Haining Chen, Wei Gao, Na Xie, Qiang Chen, Xiaofeng Zhu, Xiang Liu, Ke Xie, Yong Peng, Edouard C Nice, Min Wu, Canhua Huang, Yuquan Wei
Bleomycin is a clinically potent anticancer drug used for the treatment of germ-cell tumors, lymphomas and squamous-cell carcinomas. Unfortunately, the therapeutic efficacy of bleomycin is severely hampered by the development of pulmonary fibrosis. However, the mechanisms underlying bleomycin-induced pulmonary fibrosis, particularly the molecular target of bleomycin, remains unknown. Here, using a chemical proteomics approach, we identify ANXA2 (annexin A2) as a direct binding target of bleomycin. The interaction of bleomycin with ANXA2 was corroborated both in vitro and in vivo...
November 26, 2017: Autophagy
https://www.readbyqxmd.com/read/29152144/tissue-type-plasminogen-activator-modulates-macrophage-m2-to-m1-phenotypic-change-through-annexin-a2-mediated-nf-%C3%AE%C2%BAb-pathway
#18
Ling Lin, Kebin Hu
Macrophage accumulation is one of the hallmarks of progressive kidney disease. In response to injury, macrophages undergo a phenotypic polarization to become two functionally distinct subsets: M1 and M2 macrophages. Macrophage polarization is a dynamic process, and recent work indicates that macrophages, in response to kidney injury, can shift their polarity. However, the underlying mechanisms remain largely unknown. Tissue-type plasminogen activator (tPA), a protease up-regulated in the chronically injured kidneys, has been shown to preferably promote M1 macrophage accumulation and renal inflammation...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29115416/annexin-a2-and-cancer-a-systematic-review
#19
Maria V Christensen, Claus K Høgdall, Kirsten M Jochumsen, Estrid V S Høgdall
Annexin A2 is a 36-kDa protein interfering with multiple cellular processes especially in cancer progression. The present review aimed to show the relations between Annexin A2 and cancer. A systematic search for studies investigating cancer and Annexin A2 expression was conducted using PubMed. Acute lymphoblastic leukaemia, acute promyelocytic leukaemia, clear cell renal cell carcinoma, breast, cervical, colorectal, endometrial, gastric cancer, glioblastoma, hepatocellular carcinoma, lung, multiple myeloma, oesophageal squamous cell carcinoma, ovarian cancer, pancreatic duct adenocarcinoma, prostate cancer and urothelial carcinoma were evaluated...
November 8, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29044433/pregnancy-induced-changes-in-metabolome-and-proteome-in-ovine-uterine-flushings
#20
Jared J Romero, Bethany E Liebig, Corey D Broeckling, Jessica E Prenni, Thomas R Hansen
Mass spectrometry (MS) approaches were used herein to identify metabolites and proteins in uterine flushings (UF) that may contribute to nourishing the conceptus. Ovine uteri collected on Day 12 of the estrous cycle (n = 5 ewes exposed to vasectomized ram) or Days 12 (n = 4), 14 (n = 5), or 16 (n = 5) of pregnancy (bred with fertile ram) were flushed using buffered saline. Metabolites were extracted using 80% methanol and profiled using ultraperformance liquid chromatography (LC) tandem mass spectrometry. The proteome was examined by digestion with trypsin, followed by the analysis of peptides with LC-MS/MS...
August 1, 2017: Biology of Reproduction
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