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https://www.readbyqxmd.com/read/29049466/breast-implant-associated-anaplastic-large-cell-lymphoma-a-systematic-review
#1
Ashley N Leberfinger, Brittany J Behar, Nicole C Williams, Kevin L Rakszawski, John D Potochny, Donald R Mackay, Dino J Ravnic
Importance: Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL), a rare peripheral T-cell lymphoma, is increasing in incidence. However, many practitioners who treat patients with breast cancer are not aware of this disease. Objectives: To assess how BIA-ALCL develops, its risk factors, diagnosis, and subsequent treatment and to disseminate information about this entity to the medical field. Evidence Review: A literature review was performed in an academic medical setting...
October 18, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29049360/the-bacterial-virulence-factor-caga-induces-microbial-dysbiosis-that-contributes-to-excessive-epithelial-cell-proliferation-in-the-drosophila-gut
#2
Tiffani Alvey Jones, Diane Z Hernandez, Zoë C Wong, Anica M Wandler, Karen Guillemin
Gut microbiota facilitate many aspects of human health and development, but dysbiotic microbiota can promote hyperplasia and inflammation and contribute to human diseases such as cancer. Human patients infected with the gastric cancer-causing bacterium Helicobacter pylori have altered microbiota; however, whether dysbiosis contributes to disease in this case is unknown. Many H. pylori human disease phenotypes are associated with a potent virulence protein, CagA, which is translocated into host epithelial cells where it alters cell polarity and manipulates host-signaling pathways to promote disease...
October 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29049277/update-interim-guidance-for-the-diagnosis-evaluation-and-management-of-infants-with-possible-congenital-zika-virus-infection-united-states-october-2017
#3
Tolulope Adebanjo, Shana Godfred-Cato, Laura Viens, Marc Fischer, J Erin Staples, Wendi Kuhnert-Tallman, Henry Walke, Titilope Oduyebo, Kara Polen, Georgina Peacock, Dana Meaney-Delman, Margaret A Honein, Sonja A Rasmussen, Cynthia A Moore
CDC has updated its interim guidance for U.S. health care providers caring for infants with possible congenital Zika virus infection (1) in response to recently published updated guidance for health care providers caring for pregnant women with possible Zika virus exposure (2), unknown sensitivity and specificity of currently available diagnostic tests for congenital Zika virus infection, and recognition of additional clinical findings associated with congenital Zika virus infection. All infants born to mothers with possible Zika virus exposure* during pregnancy should receive a standard evaluation at birth and at each subsequent well-child visit including a comprehensive physical examination, age-appropriate vision screening and developmental monitoring and screening using validated tools (3-5), and newborn hearing screen at birth, preferably using auditory brainstem response (ABR) methodology (6)...
October 20, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29048477/the-role-of-toxins-in-clostridium-difficile-infection
#4
Ramyavardhanee Chandrasekaran, D Borden Lacy
Clostridium difficile is a bacterial pathogen that is the leading cause of nosocomial antibiotic-associated diarrhea and pseudomembranous colitis worldwide. The incidence, severity, mortality and healthcare costs associated with C. difficile infection (CDI) are rising, making C. difficile a major threat to public health. Traditional treatments for CDI involve use of antibiotics such as metronidazole and vancomycin, but disease recurrence occurs in about 30% of patients, highlighting the need for new therapies...
October 18, 2017: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/29047423/antimicrobial-nonsusceptibility-of-gram-negative-bloodstream-isolates-veterans-health-administration-system-united-states-2003-2013-1
#5
Michihiko Goto, Jennifer S McDanel, Makoto M Jones, Daniel J Livorsi, Michael E Ohl, Brice F Beck, Kelly K Richardson, Bruce Alexander, Eli N Perencevich
Bacteremia caused by gram-negative bacteria is associated with serious illness and death, and emergence of antimicrobial drug resistance in these bacteria is a major concern. Using national microbiology and patient data for 2003-2013 from the US Veterans Health Administration, we characterized nonsusceptibility trends of community-acquired, community-onset; healthcare-associated, community-onset; and hospital-onset bacteremia for selected gram-negative bacteria (Escherichia coli, Klebsiella spp., Pseudomonas aeruginosa, and Acinetobacter spp...
November 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29047422/mycoplasma-genitalium-infection-in-adults-reporting-sexual-contact-with-infected-partners-australia-2008-2016
#6
Josephine B Slifirski, Lenka A Vodstrcil, Christopher K Fairley, Jason J Ong, Eric P F Chow, Marcus Y Chen, Timothy R H Read, Catriona S Bradshaw
Data on the likelihood of Mycoplasma genitalium infection in sexual contacts, particularly for men who have sex with men (MSM), are needed to form an evidence base for guidelines. We conducted a cross-sectional analysis of patients attending a sexual health clinic in Melbourne, Victoria, Australia, during 2008-2016. We calculated the proportion of contacts with M. genitalium infection and determined factors associated with infection. Among those patients reporting sexual contact with an M. genitalium-infected person, 48...
November 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29047340/occupational-blood-exposures-in-health-care-workers-incidence-characteristics-and-transmission-of-bloodborne-pathogens-in-south-korea
#7
Ju Hyun Lee, Junhyeon Cho, Yung Jung Kim, Sang Hyuk Im, Eun Sun Jang, Jin-Wook Kim, Hong Bin Kim, Sook-Hyang Jeong
BACKGROUND: Health care workers (HCWs) are at high risk for occupational blood exposures (OBEs) and transmission of bloodborne pathogens. This study elucidated the incidence rate and epidemiological characteristics of OBEs among HCWs and investigated the pathogen transmission rate for hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV). METHODS: Self-reported OBEs from January 1, 2011 to December 31, 2015 were obtained from the electronic recording system...
October 18, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29046432/alk-is-a-therapeutic-target-for-lethal-sepsis
#8
Ling Zeng, Rui Kang, Shan Zhu, Xiao Wang, Lizhi Cao, Haichao Wang, Timothy R Billiar, Jianxin Jiang, Daolin Tang
Sepsis, a life-threatening organ dysfunction caused by infection, is a major public health concern with limited therapeutic options. We provide evidence to support a role for anaplastic lymphoma kinase (ALK), a tumor-associated receptor tyrosine kinase, in the regulation of innate immunity during lethal sepsis. The genetic disruption of ALK expression diminishes the stimulator of interferon genes (STING)-mediated host immune response to cyclic dinucleotides in monocytes and macrophages. Mechanistically, ALK directly interacts with epidermal growth factor receptor (EGFR) to trigger serine-threonine protein kinase AKT phosphorylation and activate interferon regulatory factor 3 (IRF3) and nuclear factor κB (NF-κB) signaling pathways, enabling STING-dependent rigorous inflammatory responses...
October 18, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/29046215/prospective-surveillance-of-device-associated-health-care-associated-infection-in-an-intensive-care-unit-of-a-tertiary-care-hospital-in-new-delhi-india
#9
Shilpee Kumar, Poornima Sen, Rajni Gaind, Pardeep Kumar Verma, Poonam Gupta, Prem Rose Suri, Sunita Nagpal, Anil Kumar Rai
BACKGROUND: Surveillance of health care-associated infections (HAIs) plays a key role in the hospital infection control program and reduction of HAIs. In India, most of the surveillance of HAIs is reported from private sector hospitals that do not depict the situation of government sector hospitals. Other studies do not confirm with the Centers for Disease Control and Prevention's (CDC) National Healthcare Safety Network (NHSN) surveillance criterion, or deal with ventilator-associated pneumonia (VAP) instead of ventilator-associated event (VAE)...
October 15, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/29045699/impact-of-hiv-on-the-burden-and-severity-of-influenza-illness-in-malawian-adults-a-prospective-cohort-and-parallel-case-control-study
#10
Antonia Ho, Stephen J Aston, Hannah Jary, Tamara Mitchell, Maaike Alaerts, Mavis Menyere, Jane Mallewa, Mulinda Nyirenda, Dean Everett, Robert S Heyderman, Neil French
Background: The impact of HIV infection on influenza incidence and severity in adults in sub-Saharan Africa is unclear. Seasonal influenza vaccination is recommended for HIV-infected persons in developed settings, but is rarely implemented in Africa. Methods: We conducted a prospective cohort study to compare the incidence of laboratory-confirmed influenza illness between HIV-infected and HIV-uninfected adults in Blantyre, Malawi. In a parallel case-control study, we explored risk factors for severe influenza presentation of severe (hospitalized lower respiratory tract infection (LRTI)), and mild influenza (influenza-like illness (ILI))...
October 16, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29045661/factors-associated-with-malnutrition-among-children-5-years-old-in-burkina-faso-evidence-from-the-demographic-and-health-surveys-iv-2010
#11
Ghislain G Poda, Chien-Yeh Hsu, Jane C-J Chao
Objective: To assess the factors associated with malnutrition among children <5 years in Burkina Faso. Design: This study was based on secondary analysis of cross-sectional population-based data from Burkina-Faso Demographic Health Surveys 2010. Setting: This study was carried out in Burkina Faso, West Africa. Participants: The participants were 6337 children <5 years and their mothers. Main outcome measures: Demographic characteristics, child nutrition and health status, and maternal and household information were collected...
October 17, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29045592/impact-of-public-safety-policies-on-hiv-transmission-dynamics-in-tijuana-mexico
#12
Sanjay R Mehta, Antoine Chaillon, Tommi L Gaines, Patricia E Gonzalez-Zuniga, Jamila K Stockman, Horatio Almanza-Reyes, Jose Roman Chavez, Alicia Vera, Karla D Wagner, Thomas L Patterson, Brianna Scott, Davey M Smith, Steffanie A Strathdee
Background: North Tijuana, Mexico, along the US border, is home to many individuals at high-risk for transmitting and acquiring HIV. Recently, policy shifts by local government impacted how these individuals were handled by authorities. Here we examined how this affected regional HIV transmission dynamics. Methods: HIV pol sequences and associated demographic information were collected from eight research studies enrolling persons in Tijuana, and were used to infer viral transmission patterns and transmission clusters...
October 13, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29045444/the-importance-of-public-health-poverty-reduction-programs-and-women-s-empowerment-in-the-reduction-of-child-stunting-in-rural-areas-of-moramanga-and-morondava-madagascar
#13
Chitale Remonja Rabaoarisoa, Rado Rakotoarison, Nivo Heritiana Rakotonirainy, Reziky Tiandraza Mangahasimbola, Alain Berthin Randrianarisoa, Ronan Jambou, Inès Vigan-Womas, Patrice Piola, Rindra Vatosoa Randremanana
BACKGROUND: Malnutrition accounts for 45% of mortality in children under five years old, despite a global mobilization against chronic malnutrition. In Madagascar, the most recent data show that the prevalence of stunting in children under five years old is still around 47.4%. This study aimed to identify the determinants of stunting in children in rural areas of Moramanga and Morondava districts to target the main areas for intervention. METHODS: A case-control study was conducted in children aged from 6 to 59...
2017: PloS One
https://www.readbyqxmd.com/read/29045416/neonatal-immune-response-to-rhinovirus-a16-has-diminished-dendritic-cell-function-and-increased-b-cell-activation
#14
Amanda Barlow-Anacker, Yury Bochkov, James Gern, Christine M Seroogy
BACKGROUND: Rhinovirus infections during infancy account for the majority of respiratory illness health care utilization and are an associated risk factor for subsequent development of allergic asthma. Neonatal type I interferon production is diminished compared to adults after stimulation with TLR agonists. However, broad profiling of immune cell responses to infectious rhinovirus has not been undertaken and we hypothesized that additional immune differences can be identified in neonates...
2017: PloS One
https://www.readbyqxmd.com/read/29045267/the-prevalence-and-investigation-of-risk-factors-of-oral-mucositis-in-a-pediatric-oncology-inpatient-population-a-prospective-study
#15
Gabrielle Allen, Richard Logan, Tom Revesz, Dorothy Keefe, Sam Gue
BACKGROUND: Oral mucositis can be a frequent and severe complication of chemotherapy in children. It can result in pain, infection, depression, prolonged admission, treatment delays, increase in patient morbidity, and increased costs. AIM: To record the prevalence and severity of oral mucositis among inpatients and explore the relationship of risks factors and the development of oral mucositis. DESIGN: During an 18-month period 643 clinical inpatient assessments were completed on 73 children who were admitted and had received chemotherapy in the last 14 days...
October 17, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29045253/gut-microbial-diversity-in-hiv-infection-post-combined-antiretroviral-therapy-a-key-target-for-prevention-of-cardiovascular-disease
#16
Mohamed El-Far, Cécile L Tremblay
PURPOSE OF REVIEW: Although the HIV-infected population is living longer and getting older under current treatment regimens, significant challenges arise for health management as the infection is associated with various premature aging phenotypes, particularly increased incidence of cardiovascular diseases (CVDs). Here we review the current understanding of HIV-related gut dysbiosis in association with CVD and advances in clinical trials aiming to restore gut microbial diversity. RECENT FINDING: Identification of a unique signature for gut dysbiosis in HIV infection between different cohorts remains challenging...
October 17, 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/29044371/nosocomial-amplification-of-mers-coronavirus-in-south-korea-2015
#17
Maimuna S Majumder, John S Brownstein, Stan N Finkelstein, Richard C Larson, Lydia Bourouiba
Background: Nosocomial amplification resulted in nearly 200 cases of Middle East respiratory syndrome (MERS) during the 2015 South Korean MERS-coronavirus outbreak. It remains unclear whether certain types of cases were more likely to cause secondary infections than others, and if so, why. Methods: Publicly available demographic and transmission network data for all cases were collected from the Ministry of Health and Welfare. Statistical analyses were conducted to determine the relationship between demographic characteristics and the likelihood of human-to-human transmission...
June 1, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29044045/emergence-of-carp-edema-virus-cev-and-its-significance-to-european-common-carp-and-koi-cyprinus-carpio
#18
REVIEW
K Way, O Haenen, D Stone, M Adamek, S M Bergmann, L Bigarré, N Diserens, M El-Matbouli, M C Gjessing, V Jung-Schroers, E Leguay, M Matras, N J Olesen, V Panzarin, V Piačková, A Toffan, N Vendramin, T Vesel, T Waltzek
Carp edema virus disease (CEVD), also known as koi sleepy disease, is caused by a poxvirus associated with outbreaks of clinical disease in koi and common carp Cyprinus carpio. Originally characterised in Japan in the 1970s, international trade in koi has led to the spread of CEV, although the first recognised outbreak of the disease outside of Japan was not reported until 1996 in the USA. In Europe, the disease was first recognised in 2009 and, as detection and diagnosis have improved, more EU member states have reported CEV associated with disease outbreaks...
October 18, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/29044039/myxobolus-arcticus-and-parvicapsula-minibicornis-infections-in-sockeye-salmon-oncorhynchus-nerka-following-downstream-migration-in-british-columbia
#19
A M Mahony, S C Johnson, C M Neville, M E Thiess, S R M Jones
Factors influencing the health of sockeye salmon Oncorhynchus nerka in British Columbia, Canada, are important for fisheries management and conservation. Juvenile salmon originating from the Fraser River were screened for 3 enzootic parasites (Myxobolus arcticus, Parvicapsula minibicornis, Ceratonova shasta) and the bacterium Renibacterium salmoninarum. Fish were collected from the Strait of Georgia in 2010, 2011 and 2012 and genotyped to stock of origin. Trends in infection status were estimated by year, spawning zone and catch area...
October 18, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/29044013/-acute-aortic-regurgitation-due-to-infective-endocarditis
#20
Claudia M Cortés, José H Casabé, Roberto R Favaloro, Héctor Raffaelli, Eduardo Dulbecco, José Abud, Fabián Salmo, Melina Riesco, Milagros Seijo, Eduardo Guevara
Acute aortic regurgitation (AAR) due to infective endocarditis (IE) is a serious disease and usually requires surgical treatment. Our study aims to compare the clinical, echocardiographic, and microbiological characteristics as well as in-hospital outcome of patients with AAR according to the severity of heart failure (HF) and to evaluate predictors of in-hospital mortality in a tertiary centre. In a prospective analysis, we compared patients with NYHA functional class I-II HF (G1) vs. functional class III-IV HF (G2)...
2017: Medicina
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