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Inverted papilloma

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https://www.readbyqxmd.com/read/29145573/human-papillomavirus-hpv-and-somatic-egfr-mutations-are-essential-mutually-exclusive-oncogenic-mechanisms-for-inverted-sinonasal-papillomas-and-associated-sinonasal-squamous-cell-carcinomas
#1
A M Udager, J B McHugh, C M Goudsmit, H C Weigelin, M S Lim, K S J Elenitoba-Johnson, B L Betz, T E Carey, N A Brown
Background: Inverted sinonasal papilloma (ISP) is a locally aggressive neoplasm often associated with sinonasal squamous cell carcinoma (SNSCC). While the etiology of ISP is not well understood, human papillomavirus (HPV) has been detected in a subset of cases. Our group recently identified activating somatic EGFR mutations in the majority of ISP and ISP-associated SNSCC. However, the relationship between EGFR mutations and HPV infection has not been explored. Patients and Methods: We evaluated 58 ISP and 22 ISP-associated SNSCC (including 13 patients with matched ISP/SNSCC samples), as well as 14 SNSCC without clinical or pathologic evidence of an associated ISP...
November 14, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29137081/sinonasal-undifferentiated-carcinoma-originating-from-inverted-papilloma-a-case-report
#2
Jong Seung Kim, Ki Hwan Hong, Kyu Yun Jang, Jong Hoon Song
RATIONALE: Sinonasal inverted papilloma (IP) is a locally aggressive tumor found in the schneiderian membrane, lining the nasal cavity and paranasal sinuses. PATIENT CONCERNS: We report a case of a 63-year-old woman with undifferentiated carcinoma (UC) arising in an IP in the left maxillary sinus. DIAGNOSES: The preoperative diagnosis was IP of the maxillary sinus. INTERVENTIONS: We performed endoscopic medial maxillectomy to remove the remnant mass in the left maxillary sinus...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29099368/detection-of-an-unusual-inverted-schneiderian-papilloma-by-cone-beam-computed-tomography
#3
Rafael Binato Junqueira, Vinícius Dilly Almeida, Gustavo Brandão Grossi, Jamilly Aparecido Sperandio, Lays Kelmer Costa, Francielle Silvestre Verner
An inverted schneiderian papilloma (ISP) is a rare neoplasm that affects the nasal cavity or a paranasal sinus, especially the maxillary sinus. Although histologically benign, the lesion has a high potential for local destruction, has a high recurrence rate, and presents the possibility of malignant transformation into squamous cell carcinoma. To determine the extent of the injury and possible impairment of adjacent maxillofacial structures, accurate imaging, such as cone beam computed tomography (CBCT), is necessary...
November 2017: General Dentistry
https://www.readbyqxmd.com/read/29074286/endoscopic-surgery-of-the-olfactory-cleft
#4
R Jankowski, C Rumeau, P Gallet, D T Nguyen, A Russel, B Toussaint
The olfactory cleft is the specific site of development of many tumours (respiratory epithelial adenomatoid hamartoma, intestinal-type adenocarcinoma, neuroblastoma, inverted papilloma, glomangiopericytoma, etc.) and is also the site of CSF rhinorrhoea via the cribriform plate (cribri-rhinorrhoea). Olfactory cleft surgery must therefore be considered to be a specific type of surgery, complementary to ethmoidal labyrinth surgery and anterior skull base surgery. Olfactory cleft tumours can be resected according to five different surgical procedures: olfactory cleft mucosal resection, partial resection of the olfactory cleft, total resection of the olfactory cleft, unilateral endoscopic anterior skull base resection, and bilateral endoscopic anterior skull base resection...
October 23, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/29070275/long-term-follow-up-of-a-patient-with-malignant-transformation-of-inverted-papilloma-into-sinonasal-undifferentiated-carcinoma
#5
Carolyn A Orgain, Terry Y Shibuya, Lester D Thompson, David B Keschner, Rohit Garg, Jivianne T Lee
INTRODUCTION: Inverted papillomas (IP) are benign sinonasal neoplasms, which account for 0.5-4% of all nasal tumors. IPs have been known to transform into squamous cell carcinoma in 5-15% of cases. Rarely, transformations to other malignancies have been reported. Here we report a unique case of malignant transformation of an IP into sinonasal undifferentiated carcinoma (SNUC). METHODS: A case report with a literature review; institutional review board exempted. The clinical presentation, radiographic features, surgical intervention, histopathologic analysis, treatment, and outcome of the case were examined...
October 1, 2017: Allergy & Rhinology
https://www.readbyqxmd.com/read/29040365/role-of-the-akt-mtor-signaling-pathway-in-human-papillomavirus-associated-nasal-and-sinonasal-inverted-papilloma
#6
Yongliang Liu, Lihua Duan, Jie Tian, Daoliang Song, Min Zhang, Shenlin Zhao, Zhaofu Yin, Xinxin Xiang, Xuezhong Li
Nasal and sinonasal inverted papilloma (NSIP) is a benign tumor in which surface epithelial cells grow downward into the underlying supportive tissue with varying degrees of metaplasia. Human papillomavirus (HPV) has been proposed as the causal agent in the pathogenesis of this disease. Many studies have shown that HPV can activate the Akt/mechanistic target of rapamycin (mTOR) signaling pathway, but the role of this pathway in HPV-associated NSIP is largely unknown. In this study, we enrolled 40 control tissue samples and 80 NSIP tissue samples...
October 13, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29023780/quantitative-analysis-of-multiple-elements-in-healthy-and-remodeled-epithelium-from-human-upper-airway-mucosa-by-using-nuclear-microscopy
#7
Min-Qin Ren, Yu-Tao Zhou, He-Xin Chen, Tian-Ying Li, Saumitra K Vajandar, Thomas Osipowicz, Frank Watt, Chun-Wei Li
Elements are vital in airway mucosal physiology and pathology; but their distribution and levels in the mucosa remain unclear. The present study uses the state-of-the-art nuclear microscopy facility to map and quantify multiple elements in the histology sections of nasal mucosa from patients with nasal polyps or inverted papilloma. Our results demonstrate that P and Ca are the most abundant elements in mucosa and their distinct difference between epithelial and sub-epithelial regions; more importantly, our results reveal decreased amounts of Cu and Zn in the remodelled epithelium as compared to the normal epithelium...
October 11, 2017: Allergy
https://www.readbyqxmd.com/read/28973390/association-of-krouse-classification-for-sinonasal-inverted-papilloma-with-recurrence-a-systematic-review-and-meta-analysis
#8
Quentin Lisan, Antoine Moya-Plana, Pierre Bonfils
Importance: The risk factors for the recurrence of sinonasal inverted papilloma are still unclear. Objective: To investigate the potential association between the Krouse classification and the recurrence rates of sinonasal inverted papilloma. Data Sources: The EMBASE and MEDLINE databases were searched for the period January 1, 1964, through September 30, 2016, using the following search strategy: (paranasal sinuses [Medical Subject Headings (MeSH) terms] OR sinonasal [all fields]) AND (inverted papilloma [MeSH terms] OR (inverted [all fields] AND papilloma [all fields])...
November 1, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28966465/multifocal-sinonasal-inverted-papilloma-with-middle-ear-involvement
#9
E Burke Haywood, Colin Fuller, Gerhard W Hill, Felix Olobatuyi, David W Clark
Inverted papilloma of the nasal cavity is a benign neoplasm, although it can be locally invasive and has the potential for malignant degeneration. Inverted papilloma of the temporal bone is extremely rare. We describe a case of a 44-year-old woman who was treated for nasal inverted papilloma and was later found to have inverted papilloma of her temporal bone. The patient required several procedures to remove the inverted papilloma from the nasal cavity and temporal bone, and she is currently free of recurrence...
October 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28948459/nut-midline-carcinoma-a-series-of-five-cases-including-one-with-unusual-clinical-course
#10
Aanchal Kakkar, Vijay Mariadas Antony, David Victor Kumar Irugu, Narayan Adhikari, Deepali Jain
NUT midline carcinomas (NMCs) are rare, poorly differentiated tumors with aggressive biological behavior and a characteristic molecular signature. Availability of NUT antibody has facilitated diagnosis of NMC without molecular testing. We report a series of head and neck NMCs diagnosed using NUT IHC at our institute, including one case with an unusual course. Immunohistochemistry for NUT was performed in nasal and sinonasal tumors with diagnoses of undifferentiated carcinoma, poorly differentiated squamous cell carcinoma and malignant neoplasm, not otherwise specified, to identify cases of NMC...
September 25, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28947891/co-existence-of-mucin-producing-urothelial-type-adenocarcinoma-of-the-prostate-and-inverted-papilloma-of-the-bladder
#11
Xiao-Nan Mu, Si-Jun Wang, Zhi-Gang Sun, Min Zhang, Zhe Li, Long-Yang Zhang
Adenocarcinoma of prostate with mucinous differentiation arising in the male urethra is extremely rare, with only 21 cases reported in the previous literature. A diagnosis of mucin-producing urothelial carcinoma of the prostate is based on the pathology, immunohistochemistry, and clinical examination by excluding the secondary adenocarcinoma of the prostate. We present a case of unexpected mucinous urothelial carcinoma of prostate with co-existing inverted papilloma of bladder in a 57-year-old man. The patient underwent transurethral resection of the prostate (TURP) and transurethral resection of a bladder tumour (TUR-Bt), and the pathologic result showed mucinous prostate carcinoma and bladder inverted papilloma...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28936551/management-of-maxillary-sinus-inverted-papilloma-via-endoscopic-partial-medial-maxillectomy-with-an-inferior-turbinate-reversing-approach
#12
Feng Wang, Yang Yang, Shenqing Wang, Haihong Chen, Dehui Wang, Qinying Wang
The aim of this study is to evaluate the efficacy of endoscopic treatment for maxillary inverted papilloma (IP) through partial medial maxillectomy with an inferior turbinate reversing approach. A retrospective analysis of patients treated in our institution for maxillary sinus IP between July 2011 and August 2015 was performed. Demographics, operative technique, characteristics of tumors, complications, postoperative follow-up, and recurrence were evaluated. Twenty-two patients were enrolled in the study. All tumor attachments were identified intraoperatively...
December 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28860918/accidentally-diagnosed-transitional-cell-papilloma-of-the-lacrimal-sac
#13
Tarjani Vivek Dave, Dilip Mishra, Ruchi Mittal, Mohammad Javed Ali
Lacrimal sac tumors are extremely rare but can be life threatening. Seventy percent of lacrimal sac tumors are of epithelial origin. Inverted transitional cell papilloma of the lacrimal sac is a rare epithelial sinonasal tumor of benign etiology with local invasion and malignant potential. These lesions may remain undiagnosed or may present with signs and symptoms of dacryocystitis or may transform to transitional cell carcinomas. Most lesions are diagnosed intra-operatively while performing a dacryocystorhinostomy...
July 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28859706/outcomes-of-sinonasal-squamous-cell-carcinoma-with-and-without-association-of-inverted-papilloma-a-multi-institutional-analysis
#14
Brian C Lobo, Brian D'Anza, Janice L Farlow, Dennis Tang, Troy D Woodard, Jonathan Y Ting, Raj Sindwani
INTRODUCTION: Sinonasal squamous cell carcinoma (SCC) accounts for <1% of all malignancies but represents 70% of sinonasal cancer. Up to 10% of SCCs are associated with inverted papilloma (IPSCC). Studies that compare patients, treatment, and outcomes of SCC and IPSCC are absent in the literature. METHODS: A retrospective review of patients with SCC and those with IPSCC at Cleveland Clinic and Indiana University from 1995 to 2015. The records were analyzed for demographics, tumor characteristics, treatment, and outcomes...
September 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28805308/lymphocyte-profile-and-cytokine-mrna-expression-in-peripheral-blood-mononuclear-cells-of-patients-with-recurrent-respiratory-papillomatosis-suggest-dysregulated-cytokine-mrna-response-and-impaired-cytotoxic-capacity
#15
Anna Holm, Olga Nagaeva, Ivan Nagaev, Christos Loizou, Göran Laurell, Lucia Mincheva-Nilsson, Karin Nylander, Katarina Olofsson
OBJECTIVES: Recurrent respiratory papillomatosis (RRP) is a relatively rare, chronic disease caused by Human Papilloma Virus (HPV) 6 and 11, and characterized by wart-like lesions in the airway affecting voice and respiratory function. The majority of HPV infections are asymptomatic and resolve spontaneously, however, some individuals are afflicted with persistent HPV infections. Failure to eliminate HPV 6 and 11 due to a defect immune responsiveness to these specific genotypes is proposed to play a major role in the development of RRP...
August 14, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28761590/conservative-treatment-of-upper-urinary-tract-carcinoma-long-term-results
#16
Andrea Orosa Andrada, Inés Laso García, Fernando Arias Fúnez, Francisco Donis Canet, Gemma Duque Ruiz, Victoria Gómez Dos Santos, Francisco Javier Burgos Revilla
INTRODUCTION: We sought to assess the long-term results of conservative treatment for upper urinary tract carcinoma (UUTC) with regard to tumour recurrence and preservation of renal unit. METHODS: From October 1987 to January 2014, 65 patients (median age 68 years) were diagnosed with UUTC and underwent endoscopic and open surgical techniques. Thirteen patients had bilateral disease and one had a single kidney. The primary approach was endoscopic in 37 reno-ureteral units (20 percutaneous resections, 17 ureteroscopies )...
July 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28722237/bone-involvement-histopathological-evidence-for-endoscopic-management-of-sinonasal-inverted-papilloma
#17
Na Liang, Zhenxiao Huang, Honggang Liu, Junfang Xian, Qian Huang, Bing Zhou
OBJECTIVE: The aim of this study is to provide histopathological evidence for a better understanding of the excision of bone underlying tumor. STUDY DESIGN: Retrospective study. METHODS: Thirty patients with histopathological diagnosis of sinonasal inverted papilloma (SIP) were enrolled. All patients underwent preoperative radiography to define the tumor location. The primary tumor and underlying bone, removed during endoscopic surgery, were examined under microscope...
July 19, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28720772/blockade-of-axl-signaling-ameliorates-hpv16e6-mediated-tumorigenecity-of-cervical-cancer
#18
Eun-Hee Lee, Kon-Young Ji, Eun-Mi Kim, Su-Man Kim, Hyeong-Woo Song, Ha-Rim Choi, Byung Yeoup Chung, Hyo Jin Choi, Hyoung-Woo Bai, Hyung-Sik Kang
Axl receptor tyrosine kinase is involved in the tumorigenesis and metastasis of many cancers. Axl expression was markedly higher in human papilloma virus type 16E6 (HPV16E6)-overexpressing HeLa (HE6F) cells and lower in HPV16E6-suppressing CaSki (CE6R) cells than in the controls. SiRNA-mediated knockdown of E6 expression led to increased phosphatase and tensin homolog (PTEN) phosphorylation at Ser380 and attenuated AKT phosphorylation. Expression of membrane-associated guanylate kinase inverted-2 (MAGI-2), an E6-induced degradation target, was induced in E6-siRNA-transfected cells...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28699194/inverted-schneiderian-papilloma-of-the-supraglottis-case-report
#19
Robert Saddawi-Konefka, Nosaibah Hariri, Ahmed Shabaik, Philip A Weissbrod
Inverted schneiderian papillomas are rare benign tumors, most often arising from the sinonasal mucosa. We describe a case of a 59-year-old female with an inverted papilloma of the supraglottis. This is the first reported case of a supraglottic-presenting inverted papilloma. Although rare, this case demonstrates that these tumors should be considered during workup of supraglottic laryngeal masses. Laryngoscope, 2017.
July 12, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28693263/role-of-microrna-296-3p-in-the-malignant-transformation-of-sinonasal-inverted-papilloma
#20
Tomohiko Kakizaki, Hiromitsu Hatakeyama, Yuji Nakamaru, Dai Takagi, Takatsugu Mizumachi, Tomohiro Sakashita, Satoshi Kano, Akihiro Homma, Satoshi Fukuda
Inverted papilloma (IP) is a benign tumor occurring in the nasal cavity and paranasal sinuses. It is reported that 5-15% of IPs undergo malignant transformation into squamous cell carcinoma (SCC), and the role of microRNAs (miRNA/miR) in this process remains to be elucidated. In the present study, whole miRNA profiles using samples of IP and SCC were investigated, in order to detect the function of miRNA in the carcinogenesis of IP. Samples from IPs (n=5) and SCC lesions (n=5), which arose from IPs, were used for miRNA analysis...
July 2017: Oncology Letters
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