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https://www.readbyqxmd.com/read/28704300/postinfectious-heterotopic-ossification-of-the-ilium-involving-the-iliacus-muscle
#1
Ferdhany Muhamad Effendi, Yunjin Nam, Chang Ho Shin, Tae-Joon Cho, Won Joon Yoo, Jung-Eun Cheon, In Ho Choi
Heterotopic ossification in soft tissue or muscle is rare in the pediatric and adolescent age group. Most cases are associated with musculoskeletal injury and trauma to the central nervous system. Here, we describe an adolescent patient without a history of trauma or lesions in the central nervous system who presented with a painful limp with limited motion of the left hip. Investigations indicated unusually large heterotopic ossification extending from the inner aspect of the ilium down to the anterior part of the hip, highly likely to have developed after an unrecognized periacetabular pyomyositis primarily involving the iliacus muscle...
July 12, 2017: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/28685087/heterogeneity-in-the-colorectal-primary-tumor-and-the-synchronous-resected-liver-metastases-prior-to-and-after-treatment-with-an-anti-egfr-monoclonal-antibody
#2
Daniela Adua, Francesca Di Fabio, Giorgio Ercolani, Michelangelo Fiorentino, Elisa Gruppioni, Annalisa Altimari, Fabiola Lorena Rojas Limpe, Nicola Normanno, Antonio Daniele Pinna, Carmine Pinto
Molecular heterogeneity between primary tumors (PTs) and synchronous resected liver metastasis in colorectal cancer (CRC) has potential relevance in treatment strategies. Next-generation sequencing (NGS) may be able to increase the chances of identifying multiple molecular driver alterations, calling for therapy. The aim of the present study was to evaluate mutations in PT and synchronous resected liver metastases for patients with Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) exon 2 wild-type metastatic (m)CRC who underwent chemotherapy (CT) featuring an anti-epidermal growth factor receptor (EGFR) monoclonal antibody...
July 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28681516/walking-in-circles-the-limping-child
#3
Tessa Davis, Ben Lawton, Kristina Klein, Henry Goldstein, Andrew Tagg
No abstract text is available yet for this article.
July 5, 2017: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/28672992/inhibition-of-viral-replication-by-small-interfering-rna-targeting-of-the-foot-and-mouth-disease-virus-receptor-integrin-%C3%AE-6
#4
Na-Na Hu, Wenzhi Zhang, Lina Wang, Yuan-Zhi Wang, Chuang-Fu Chen
In animals, foot-and-mouth disease (FMD) causes symptoms such as fever, limping and the development of blister spots on the skin and mucous membranes. RNA interference (RNAi) may be a novel way of controlling the FMD virus (FMDV), specifically by targeting its cognate receptor protein integrin β6. The present study used RNAi technology to construct and screen plasmids that expressed small interfering RNA molecules (siRNAs) specific for the integrin β6 subunit. Expression of green fluorescence protein from the RNAi plasmids was observed following transfection into porcine embryonic fibroblast (PEF) cells, and RNAi plasmids were screened using reverse transcription-quantitative polymerase chain reaction (RT-qPCR) analysis...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28671425/slipped-capital-femoral-epiphysis-diagnosis-and-management
#5
David M Peck, Lisa M Voss, Tyler T Voss
Slipped capital femoral epiphysis (SCFE) is the most common hip disorder in adolescents, occurring in 10.8 per 100,000 children. SCFE usually occurs in those eight to 15 years of age and is one of the most commonly missed diagnoses in children. SCFE is classified as stable or unstable based on the stability of the physis. It is associated with obesity, growth spurts, and (occasionally) endocrine abnormalities such as hypothyroidism, growth hormone supplementation, hypogonadism, and panhypopituitarism. Patients with SCFE usually present with limping and poorly localized pain in the hip, groin, thigh, or knee...
June 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/28657842/journal-club-can-coronal-stir-be-used-as-screening-for-acute-nontraumatic-hip-pain-in-children
#6
Monica M Forbes-Amrhein, Megan B Marine, Matthew R Wanner, Trenton D Roth, Joseph T Davis, Ananth K Ravi, Boaz Karmazyn
OBJECTIVE: The objective of this study is to evaluate whether coronal STIR MRI can be used as a screening test for nontraumatic acute hip pain in children. MATERIALS AND METHODS: From 2008 to 2012, we identified all patients younger than 18 years at our tertiary care facility who underwent pelvic MRI including coronal STIR for the following indications: acute hip pain, limping, or refusal to bear weight. Patients with a history of trauma were excluded. Each MR image was independently reviewed by four radiologists who were blinded to the clinical outcome...
June 28, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28648042/-effects-of-lappaconitine-on-pain-and-inflammatory-response-of-severely-burned-rats-and-the-mechanism
#7
C L Yang, Z R Wei, T H Zhang, X Q Zeng, B H Wu
Objective: To explore the effects of lappaconitine (LA) on pain and inflammatory response of severely burned rats and the mechanism. Methods: Forty SD rats were divided into healthy+ normal saline group, sham injury+ normal saline group, pure burn group, burn+ LA group, and healthy+ LA group according to the random number table (the same dividing method below), with 8 rats in each group. Rats in pure burn and burn+ LA groups were inflicted with about 32% total body surface area deep partial-thickness scald (hereinafter referred to as burn) on the back and right hind...
June 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28630834/van-neck-odelberg-disease-a-rare-case-report
#8
Amit Prakash Chaudhari, Gautam Shah, Sameer Sanjeev Patil, Aashish Babanrao Ghodke, Sagar B Kelkar
INTRODUCTION: Pain in groin without any history of trauma or positive clinical findings of infection or stress fracture in ischiopubic ramus poses challenges in diagnosis of the condition in prepubertal age. "Osteochondrosis of ischiopubic synchondrosis (IPS)" also called as "Van Neck-Odelberg" disease. Left leg dominant patient presented with pain in groin and limping with left leg dominance. Differential diagnosis - such as stress fractures, osteomyelitis, tuberculosis, post-traumatic osteolysis, or any neoplasia - is need be ruled out to arrive at diagnosis...
January 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28608179/anterior-submandibular-retropharyngeal-odontoid-osteotomy-and-posterior-atlantoaxial-fusion-for-irreducible-atlantoaxial-dislocation-associated-with-odontoid-fracture-malunion
#9
Cheng Li, Jingzhu Duan, Lei Li
PURPOSE: To report a case of complex odontoid fracture malunion accompanied by atlantoaxial dislocation which was treated with a new surgical approach. METHODS: A 53-year-old female was admitted due to progressive symptoms with a stiff limp and unsteady gait. Preoperative examination, diagnostic radiography, computed tomography, and magnetic resonance imaging were performed following admission. The examinations showed odontoid fracture malunion, an old right axial zygapophyseal fracture, atlantoaxial dislocation, and spinal cord injury...
June 12, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28593072/recovery-and-return-to-work-after-a-pelvic-fracture
#10
Antonios N Papasotiriou, Nikolaos Prevezas, Konstantinos Krikonis, Evangelos C Alexopoulos
BACKGROUND: Pelvic ring fractures (PRFs) may influence the daily activities and quality of life of the injured. The aim of this retrospective study was to explore the functional outcomes and factors related to return to work (RTW) after PRF. METHODS: During the years 2003-2012, 282 injured individuals aged 20-55 years on the date of the accident, were hospitalized and treated for PRFs in a large tertiary hospital in Athens, Greece. One hundred and three patients were traced and contacted; 77 who were on paid employment prior to the accident gave their informed consent to participate in the survey, which was conducted in early 2015 through telephone interviews...
June 2017: Safety and Health At Work
https://www.readbyqxmd.com/read/28570363/point-of-care-ultrasound-identification-of-a-psoas-abscess-in-a-child-presenting-with-hip-pain
#11
Julia K Deanehan
This case-report describes a 4-year-old girl brought to the emergency department for the evaluation of limp and elevated inflammatory markers. The patient's history and physical examination did not reveal a clear source of pathology. Point-of-care ultrasound identified a right-sided psoas abscess that was confirmed with computed tomography scan. This case demonstrates the potential utility of point-of-care ultrasound in the diagnosis and management of patients presenting to the emergency department with symptoms concerning for pathology in the hip or lower abdomen...
June 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28556863/use-of-the-fascial-distortion-model-to-evaluate-a-limp-in-a-child
#12
Sarah J James, Jasmine Hudnall
Pediatric limp is a relatively common condition in primary care and can be challenging to diagnose and manage. Common causes of painful pediatric limp include transient synovitis, septic arthritis, osteomyelitis, and trauma. The authors present the case of an 11-year-old girl with a painful limp and anterior ankle pain of unclear origin. Osteopathic structural examination revealed a somatic dysfunction known as continuum distortion, 1 of 6 fascial alterations identified in the fascial distortion model. Myofascial release was applied, providing rapid, complete resolution of symptoms...
June 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/28525314/malaria-parasite-limp-protein-regulates-sporozoite-gliding-motility-and-infectivity-in-mosquito-and-mammalian-hosts
#13
Jorge M Santos, Saskia Egarter, Vanessa Zuzarte-Luís, Hirdesh Kumar, Catherine A Moreau, Jessica Kehrer, Andreia Pinto, Mário da Costa, Blandine Franke-Fayard, Chris J Janse, Friedrich Frischknecht, Gunnar R Mair
Gliding motility allows malaria parasites to migrate and invade tissues and cells in different hosts. It requires parasite surface proteins to provide attachment to host cells and extracellular matrices. Here, we identify the Plasmodium protein LIMP (the name refers to a gliding phenotype in the sporozoite arising from epitope tagging of the endogenous protein) as a key regulator for adhesion during gliding motility in the rodent malaria model P. berghei. Transcribed in gametocytes, LIMP is translated in the ookinete from maternal mRNA, and later in the sporozoite...
May 2, 2017: ELife
https://www.readbyqxmd.com/read/28507961/total-hip-arthroplasty-indicated-for-a-tuberculous-coxitis-complicating-a-controlled-acquired-imunodefficiency-syndrom-condition-a-preliminary-report-concerning-a-case
#14
Handy Eone Daniel, Jean Emile Bayiha, Théophyle Chunteng Nana, Olivier Kennedy Muluem, Jean Bahebeck
INTRODUCTION: Total hip arthroplasty (THA) remains controversial in active tuberculosis (TB) infection because of the risks of septic loosening and reactivation of the infection. We present a rare case of THA in a patient positive for the human immunodeficiency virus (HIV) with active tuberculous coxitis. The aim of this work is to share our experience and our preliminary results. CASE REPORT: The patient was a 53-year-old Black African woman, positive for the HIV, who was operated for implantation of a THA via the Hardinge approach indicated for a severe painful hip with restriction of joint movement and limp...
November 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28464754/patient-reported-outcome-after-total-hip-arthroplasty-comparison-between-lateral-and-posterior-approach
#15
Signe Rosenlund, Leif Broeng, Anders Holsgaard-Larsen, Carsten Jensen, Søren Overgaard
Background and purpose - Criticism of the lateral approach (LA) for hip arthroplasty is mainly based on the risk of poor patient-reported outcomes compared to the posterior approach (PA). However, there have been no controlled studies comparing patient-reported outcomes between them. In this randomized controlled trial, we tested the hypothesis that patient-reported outcomes are better in patients who have undergone total hip arthroplasty (THA) with PA than in those who have undergone THA with LA, 12 months postoperatively...
June 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28434011/management-of-coxa-vara-septica-and-pseudoarthrosis-of-the-femoral-neck-a-case-report
#16
Hasime Qorraj Bytyqi, Cen Bytyqi
BACKGROUND Coxa vara and pseudoarthrosis of the femoral neck after septic hip arthritis is a very rare disease. The aim of this study was to present a case with pseudoarthrosis of the femoral neck, with coxa vara after neonatal septic arthritis of the right hip, and treatment of the pseudarthrosis with proximal femoral valgus osteotomy. CASE REPORT A 12-month-old female, who had suffered neonatal septic arthritis with a five-day history of fever and painful right hip now demonstrated painless limping to the right hip, pelvic obliquity, Trendelenburg-Duchenne gait, limitation of hip abduction, lower-extremity length discrepancy with 3...
April 23, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28408083/masquelet-technique-versus-ilizarov-bone-transport-for-reconstruction-of-lower-extremity-bone-defects-following-posttraumatic-osteomyelitis
#17
Kai Tong, Ziyi Zhong, Yulan Peng, Chuangxin Lin, Shenglu Cao, YunPing Yang, Gang Wang
OBJECTIVE: This study was to compare the effectiveness of Masquelet technique versus Ilizarov bone transport in the treatment of lower extremity bone defects following posttraumatic osteomyelitis. PATIENTS AND METHODS: We retrospectively reviewed 39 patients who had been treated at our department for lower extremity bone defects following posttraumatic osteomyelitis. They were 30 males and 9 females with a mean age of 39.18 (range, 12-63 years). The infected bone defects involved 26 tibias and 13 femurs...
April 4, 2017: Injury
https://www.readbyqxmd.com/read/28316857/progressive-pseudorheumatoid-dysplasia-or-jia
#18
Geetha Wickrematilake
Progressive pseudorheumatoid dysplasia (PPD) or spondyloepiphyseal dysplasia tarda with progressive arthropathy (SEDT-PA) is a rare arthropathy of childhood involving the axial skeleton as well as small peripheral joints. A 10-year-old boy was referred by a general practitioner with pain and deformity in the fingers of hands and limping gait. There was no joint synovitis although the finger joints were bulky on examination with mild flexion deformity. Patient had exaggerated kyphosis and lumbar lordosis with pigeon chest and restricted hip joint movements...
2017: Case Reports in Rheumatology
https://www.readbyqxmd.com/read/28285866/obstructed-infradiaphragmatic-total-anomalous-pulmonary-venous-return-in-a-13-day-old-infant-presenting-acutely-to-the-emergency-department-a-case-report
#19
Elizabeth A Siacunco, Garrett S Pacheco, Dale P Woolridge
BACKGROUND: Total anomalous pulmonary venous return (TAPVR) is an uncommon congenital heart defect. Obstructed forms are more severe, and typically present earlier in life, usually in the immediate newborn period, with symptoms of severe cyanosis and respiratory failure. CASE REPORT: A 13-day-old boy presented to the emergency department (ED) with respiratory extremis. He appeared cyanotic and limp, and was found to have significant hypoxia with oxygen saturation of 40%...
March 9, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28265296/fit-to-play-posture-and-seating-position-analysis-with-professional-musicians-a-study-protocol
#20
Daniela Ohlendorf, Eileen M Wanke, Natalie Filmann, David A Groneberg, Alexander Gerber
BACKGROUND: Musical performance-associated musculoskeletal disorders (MSD) are a common health problem among professional musicians. Considering the manifold consequences arising for the musicians, they can be seen as a threat for their professional activity. String players are the most affected group of musicians in this matter. Faults in upper body posture while playing the instrument, causing un-ergonomic static strain on the back and unergonomic limp-movements, are a main reason for musculoskeletal disorders and pain syndromes...
2017: Journal of Occupational Medicine and Toxicology
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