keyword
https://read.qxmd.com/read/38314503/pirnas-in-the-human-retina-and-retinal-pigment-epithelium-reveal-a-potential-role-in-intracellular-trafficking-and-oxidative-stress
#21
JOURNAL ARTICLE
Muthuramalingam Karpagavalli, Suganya Sivagurunathan, T Sayamsmruti Panda, Nagesh Srikakulam, Reety Arora, Lamiya Dohadwala, Basant K Tiwary, Sudha Rani Sadras, Jayamuruga Pandian Arunachalam, Gopal Pandi, Subbulakshmi Chidambaram
Long considered active only in the germline, the PIWI/piRNA pathway is now known to play a significant role in somatic cells, especially neurons. In this study, piRNAs were profiled in the human retina and retinal pigment epithelium (RPE). Furthermore, RNA immunoprecipitation with HIWI2 (PIWIL4) in ARPE19 cells yielded 261 piRNAs, and the expression of selective piRNAs in donor eyes was assessed by qRT-PCR. Intriguingly, computational analysis revealed complete and partial seed sequence similarity between piR-hsa-26131 and the sensory organ specific miR-183/96/182 cluster...
February 5, 2024: Molecular Omics
https://read.qxmd.com/read/38312596/long-noncoding-rna-lnc-snapc5-3-4-inhibits-malignancy-by-directly-upregulating-mir-224-3p-in-non-small-cell-lung-cancer
#22
JOURNAL ARTICLE
Chenxi Hu, Shuo Wu, Wen Sun, Jiawen Li, Kaiyuan Hui, Xiaodong Jiang
The mounting body of evidence demonstrates the growing importance of long noncoding RNAs in the advancement of tumors. This study aimed to investigate the molecular mechanism of lnc-SNAPC5-3:4 in non-small cell lung cancer (NSCLC). We investigated the expression of miR-224-3p and lnc-SNAPC5-3:4 in clinical NSCLC samples and NSCLC cell lines using reverse transcription polymerase chain reaction (RT-PCR). In vitro studies, A549 cell growth was estimated using Cell Counting Kit-8 (CCK-8), 5-ethynyl-2'-deoxyuridine (EDU), and flow cytometry assays...
January 30, 2024: Heliyon
https://read.qxmd.com/read/38306545/exploring-the-mechanism-of-lncrna-casc15-affecting-hepatocellular-carcinoma-through-mirna
#23
JOURNAL ARTICLE
Qingshan Cai, Dongyang Wu, Yueling Shen, Shudong Li, Liyou Liu, Dong Liu, Yong Li, Xiaonan Chen, Limin Wang, Jianxing Zheng
This study aimed to determine the potential mechanisms through which long noncoding (Lnc) RNA cancer susceptibility candidate 15 (CASC15) affects hepatocellular carcinoma (HCC). We retrieved HCC RNA-seq and clinical information from the UCSC Xena database. The differential expression (DE) of CASC15 was detected. Overall survival was analyzed using Kaplan-Meier (K-M) curves. Molecular function and signaling pathways affected by CASC15 were determined using Gene Set Enrichment Analysis. Associations between CASC15 and the HCC microenvironment were investigated using immuno-infiltration assays...
February 2, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38291129/histone-3-lysine-9-acetylation-specific-reprogramming-regulates-esophageal-squamous-cell-carcinoma-progression-and-metastasis
#24
JOURNAL ARTICLE
Zhenhui Chen, Chenghao Li, Yue Zhou, Pengcheng Li, Guoquan Cao, Yunbo Qiao, Yinghao Yao, Jianzhong Su
Dysregulation of histone acetylation is widely implicated in tumorigenesis, yet its specific roles in the progression and metastasis of esophageal squamous cell carcinoma (ESCC) remain unclear. Here, we profiled the genome-wide landscapes of H3K9ac for paired adjacent normal (Nor), primary ESCC (EC) and metastatic lymph node (LNC) esophageal tissues from three ESCC patients. Compared to H3K27ac, we identified a distinct epigenetic reprogramming specific to H3K9ac in EC and LNC samples relative to Nor samples...
January 30, 2024: Cancer Gene Therapy
https://read.qxmd.com/read/38289583/lnc-rna-loc102163816-promotes-proliferation-of-porcine-follicular-granulosa-cells-via-mir-455-3p-ptk2b-pi3%C3%A2-k-akt-pathway
#25
JOURNAL ARTICLE
Caomeihui Shen, Tong Chen, Guitian He, Kening Liu, Maosheng Cao, Chenfeng Yuan, Boqi Zhang, Xue Chen, Lu Chen, Yuxin Luo, Yueying Wang, Xu Zhou, Chunjin Li
The proliferation and differentiation of granulosa cells (GCs) is a crucial process in follicular development. However, the molecular regulatory mechanism of follicular proliferation and differentiation of GCs needs further research. Studies have reported that follicular fluid exosomes are involved in regulation of proliferation of GCs, but the specific mechanism is unclear. This study demonstrated that LOC102163816 is upregulated in porcine GCs treated with follicular fluid exosomes. Further study defined LOC102163816 to be a novel long non-coding RNA that is highly homologous to human metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and enriched in porcine follicular fluid exosomes...
January 30, 2024: Endocrinology
https://read.qxmd.com/read/38286681/defective-homologous-recombination-repair-by-up-regulating-lnc-hz10-ahr-loop-in-human-trophoblast-cells-induced-miscarriage
#26
JOURNAL ARTICLE
Weina Chen, Chenyang Mi, Ying Zhang, Yang Yang, Wenxin Huang, Zhongyan Xu, Jingsong Zhao, Rong Wang, Manli Wang, Shukun Wan, Xiaoqing Wang, Huidong Zhang
Human trophoblast cells are crucial for healthy pregnancy. However, whether the defective homologous recombination (HR) repair of dsDNA break (DSB) in trophoblast cells may induce miscarriage is completely unknown. Moreover, the abundance of BRCA1 (a crucial protein for HR repair), its recruitment to DSB foci, and its epigenetic regulatory mechanisms, are also fully unexplored. In this work, it is identified that a novel lnc-HZ10, which is highly experssed in villous tissues of recurrent miscarriage (RM) vs their healthy control group, suppresses HR repair of DSB in trophoblast cell...
January 29, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38242290/rab5c-promotes-rsv-and-adv-replication-by-autophagy-in-respiratory-epithelial-cells
#27
JOURNAL ARTICLE
Xiuli Wang, Jing Cheng, Linchao Shen, Meixi Chen, Keran Sun, Jian Li, Miao Li, Cuiqing Ma, Lin Wei
Respiratory system diseases caused by respiratory viruses are common and exert tremendous pressure on global healthcare system. In our previous studies, we found that Long non-coding RNA NRAV (Lnc NRAV) and its target molecule Rab5c plays a significant role in respiratory virus infection. However, the mechanism by which Rab5c affects virus replication remains unclear. Rab5c, a protein mainly localized on the cell membranes and in early endosomes and phagosomes, participates in endocytosis mediated by clathrin and regulates the fusion of early endosome, maturation of early phagosomes, and autophagy...
January 20, 2024: Virus Research
https://read.qxmd.com/read/38225540/lnc-psma8-1-activated-by-geft-promotes-rhabdomyosarcoma-progression-via-upregulation-of-mtor-expression-by-sponging-mir-144-3p
#28
JOURNAL ARTICLE
Lian Meng, Hao Shang, Qianqian Liu, Zhenzhen Li, Xiaomeng Wang, Qianru Li, Feng Li, Zhenguo Zhao, Chunxia Liu
BACKGROUND: GEFT is a key regulator of tumorigenesis in rhabdomyosarcoma (RMS), and overexpression of GEFT is significantly correlated with distant metastasis, lymph node metastasis, and a poor prognosis, yet the underlying molecular mechanism is still poorly understood. This study aimed to investigate and validate the molecular mechanism of GEFT-activated lncRNAs in regulating mTOR expression to promote the progression of RMS. METHODS: GEFT-regulated lncRNAs were identified through microarray analysis...
January 15, 2024: BMC Cancer
https://read.qxmd.com/read/38220553/lnc-ing-rna-to-intestinal-homeostasis-and-inflammation
#29
REVIEW
Katherine A Fitzgerald, Liraz Shmuel-Galia
Long noncoding RNAs (lncRNAs) play important roles in numerous biological processes, including the immune system. Initial research in this area focused on cell-based studies, but recent advances underscore the profound significance of lncRNAs at the organismal level, providing invaluable insights into their roles in inflammatory diseases. In this rapidly evolving field, lncRNAs have been described with pivotal roles in the intestinal tract where they regulate intestinal homeostasis and inflammation by influencing processes such as immune cell development, inflammatory signaling pathways, epithelial barrier function, and cellular metabolism...
January 13, 2024: Trends in Immunology
https://read.qxmd.com/read/38199225/circulating-exosomal-lncrnas-as-novel-diagnostic-predictors-of-severity-and-sites-of-white-matter-hyperintensities
#30
JOURNAL ARTICLE
Xiang Xu, Yu Sun, Shuai Zhang, Qi Xiao, Xiao Yan Zhu, Ai Jun Ma, Xu Dong Pan
OBJECTIVE: Exosomal long noncoding RNAs (lncRNAs) are the key to diagnosing and treating various diseases. This study aimed to investigate the diagnostic value of plasma exosomal lncRNAs in white matter hyperintensities (WMH). METHODS: We used high-throughput sequencing to determine the differential expression (DE) profiles of lncRNAs in plasma exosomes from WMH patients and controls. The sequencing results were verified in a validation cohort using qRT-PCR. The diagnostic potential of candidate exosomal lncRNAs was proven by binary logistic analysis and receiver operating characteristic (ROC) curves...
December 20, 2023: Biomedical and Environmental Sciences: BES
https://read.qxmd.com/read/38193005/a-ten-long-noncoding-rna-based-prognostic-risk-model-construction-and-mechanism-study-in-the-basal-like-immune-suppressed-subtype-of-triple-negative-breast-cancer
#31
JOURNAL ARTICLE
Xiaoying Huang, Jinlong Huang, Qiuyan Huang, Shihao Zhou
BACKGROUND: According to the Fudan University Shanghai Cancer Center (FUSCC) system, triple-negative breast cancer (TNBC) is divided into four stable subtypes: (I) luminal androgen receptor, (II) immunomodulatory, (III) basal-like immune-suppressed (BLIS), and (IV) mesenchymal-like. However, the treatment outcomes of the corresponding targeted therapies are unsatisfactory, especially for the BLIS subtype. Therefore, we aimed to identify the key long noncoding RNAs (lncRNAs) to construct a prognostic model for BLIS subtype and discover potential targets to explore potential therapeutic strategies in this study...
December 31, 2023: Translational Cancer Research
https://read.qxmd.com/read/38165571/the-lncrna-lnc-tsi-antagonizes-sorafenib-resistance-in-hepatocellular-carcinoma-via-downregulating-mir-4726-5p-expression-and-upregulating-kcnma1-expression
#32
JOURNAL ARTICLE
Fengrong Chen, Jiong Jiang, Dong Liu, Hong Li, Lei Dong, Yahua Song, Ying Zhang, Jing Wang, Yun Qin, Gang Zhao
Acquired drug resistance is a main reason for limiting the application of sorafenib in HCC treatment. This study aimed to explore the role and mechanisms of a novel long non-coding RNA (lncRNA), lnc-TSI, in sorafenib resistance of HCC. The interaction between lnc-TSI and miR-4726-5p, and miR-4726-5p and KCNMA1 were predicted using bioinformatic tools. Expression of the molecules in the lnc-TSI/miR-4726-5p/KCNMA1 axis in clinical samples and cell lines, as well as the sorafenib resistant HCC cell lines, was determined using qRT-PCR or western blotting...
January 2, 2024: Journal of Molecular Histology
https://read.qxmd.com/read/38156382/lnc-anril-modulates-the-immune-response-associated-with-nf-%C3%AE%C2%BAb-pathway-in-lps-stimulated-bovine-mammary-epithelial-cells
#33
JOURNAL ARTICLE
Jinye Lu, Beibei Gu, Wei Lu, Jing Liu, Jiang Lu
BACKGROUND: The antisense noncoding RNA in the INK4 locus (ANRIL) has been confirmed related to multiple disease progression, but the role and exact mechanisms of lnc-ANRIL in lipopolysaccharide (LPS)-induced inflammation of bovine mammary epithelial cells (MAC-T) remain unclear. AIMS: This manuscript focused on expounding the functional role of lnc-ANRIL through experiments performed in MAC-T. METHODS: At the in vitro level, we established a Bovine mammary epithelial cell (BMEC) cell model of mastitis by LPS treatment...
December 2023: Immunity, Inflammation and Disease
https://read.qxmd.com/read/38156018/long-non-coding-rna-expression-in-pbmcs-of-patients-with-active-pulmonary-tuberculosis
#34
JOURNAL ARTICLE
Guoli Li, Zhelong Feng, Honghuan Song, Yajing Wang, Limei Zhu, Yan Li
PURPOSE: Mycobacterium tuberculosis (Mtb) infection is the primary cause of the chronic infectious illness tuberculosis (TB). Long non-coding RNAs (lncRNAs) are functional RNA molecules that cannot be translated into proteins and play a crucial role in regulating the immune system's innate and adaptive responses. It has been demonstrated that the dysregulation of lncRNA expression is associated with various human diseases. However, the mechanism underlying the involvement of so many lncRNAs in the immune response to TB infection remains unclear...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/38135852/lnc-hibadh-4-regulates-autophagy-lysosome-pathway-in-amyotrophic-lateral-sclerosis-by-targeting-cathepsin-d
#35
JOURNAL ARTICLE
Jingxuan Huang, Yujiao Yu, Dejiang Pang, Chunyu Li, Qianqian Wei, Yangfan Cheng, Yiyuan Cui, Ruwei Ou, Huifang Shang
Amyotrophic lateral sclerosis (ALS) is the most prevalent and lethal class of severe motor neuron diseases (MND) with no efficacious treatment. The pathogenic mechanisms underlying ALS remain unclear. Nearly 90% of patients exhibit sporadic onset (sALS). Therefore, elucidating the pathophysiology of ALS is imperative. Long non-coding RNA (lncRNA) is a large class of non-coding RNAs that regulate transcription, translation, and post-translational processes. LncRNAs contribute to the pathogenesis of diverse neurodegenerative disorders and hold promise as targets for interference in the realm of neurodegeneration...
December 22, 2023: Molecular Neurobiology
https://read.qxmd.com/read/38124119/competing-endogenous-rna-network-analysis-of-turner-syndrome-patient-specific-ipsc-derived-cardiomyocytes-reveals-dysregulation-of-autosomal-heart-development-genes-by-altered-dosages-of-x-inactivation-escaping-non-coding-rnas
#36
JOURNAL ARTICLE
Yumei Luo, Yapei Chen, Lingxia Ge, Guanqing Zhou, Yaoyong Chen, Detu Zhu
BACKGROUND: A 45,X monosomy (Turner syndrome, TS) is the only chromosome haploinsufficiency compatible with life. Nevertheless, the surviving TS patients still suffer from increased morbidity and mortality, with around one-third of them subjecting to heart abnormalities. How loss of one X chromosome drive these conditions remains largely unknown. METHODS: Here, we have generated cardiomyocytes (CMs) from wild-type and TS patient-specific induced pluripotent stem cells and profiled the mRNA, lncRNA and circRNA expression in these cells...
December 20, 2023: Stem Cell Research & Therapy
https://read.qxmd.com/read/38102732/distinctive-physical-properties-of-dna-shared-by-rna-polymerase-ii-gene-promoters-and-5%C3%A2-flanking-regions-of-trna-genes
#37
JOURNAL ARTICLE
Kohei Uemura, Takashi Ohyama
Numerous noncoding (nc)RNAs have been identified. Similar to the transcription of protein-coding (mRNA) genes, long noncoding (lnc)RNA genes and most of micro (mi)RNA genes are transcribed by RNA polymerase II (Pol II). In the transcription of mRNA genes, core promoters play an indispensable role; they support the assembly of the preinitiation complex (PIC). However, the structural and/or physical properties of the core promoters of lncRNA and miRNA genes remain largely unexplored, in contrast with those of mRNA genes...
December 15, 2023: Journal of Biochemistry
https://read.qxmd.com/read/38089592/hypoxia-induces-hepatocellular-carcinoma-metastasis-via-the-hif-1%C3%AE-mettl16-lnc-csmd1-7-rbfox2-axis
#38
JOURNAL ARTICLE
Yingchao Wang, Yong Yang, Ye Yang, Yuan Dang, Zhiting Guo, Qiuyu Zhuang, Xiaoyuan Zheng, Fei Wang, Niangmei Cheng, Xiaolong Liu, Wuhua Guo, Bixing Zhao
Hypoxic microenvironment is clinically associated with metastasis and poor prognosis of numerous cancers. The mechanisms by which intratumoral hypoxia regulates metastasis are not fully understood. Our study identifies a downregulation of Lnc-CSMD1-7 in hepatocellular carcinoma (HCC) and correlated with poor prognosis of HCC patients. Lnc-CSMD1-7 negatively regulated HCC cell migration and invasion in vitro and suppressed lung metastasis in vivo . Mechanistically, Lnc-CSMD1-7 directly binds to RBFOX2, thereby affecting RBFOX2-regulated alternative splicing in epithelial and mesenchymal-specific events...
December 15, 2023: IScience
https://read.qxmd.com/read/38059157/lnc-snhg5-promoted-hepatocellular-carcinoma-progression-through-the-rps3-nf%C3%AE%C2%BAb-pathway
#39
JOURNAL ARTICLE
Jie Hao, Yu Liu, Fengli Guo, Guiming Fu, Junya Ning, Xianhui Ruan, Xiangqian Zheng, Ming Gao
BACKGROUND: We planned to explore the underlying mechanism and clinical significance of lnc-SNHG5 and RPS3 in hepatocellular carcinoma in this current study. METHODS: The expression of Lnc-SNHG5 and RPS3 in HCC tissues and several cell lines were affirmed, respectively, using UALCAN, TIMER, TCGA and RT-qPCR assay. Cell proliferation ability was detected by colony formation assay and CCK8 assay. Cell apoptosis was monitored by flow cytometry assay. Next, the RPS3 expression levels and the related proteins in NFκB pathway were examined using Western blot analysis...
2023: International Journal of General Medicine
https://read.qxmd.com/read/38051961/expression-profiles-of-oviductal-mrnas-and-lncrnas-in-the-follicular-phase-and-luteal-phase-of-sheep-ovis-aries-with-2-fecundity-gene-fecb-genotypes
#40
JOURNAL ARTICLE
Weihao Chen, Zhifeng Li, Rongzhen Zhong, Wei Sun, Mingxing Chu
FecB (also known as BMPR1B) is a crucial gene in sheep reproduction, which has a mutation (A746G) that was found to increase the ovulation rate and litter size. The FecB mutation is associated with reproductive endocrinology, such mutation can control external estrous characteristics and affect follicle-stimulating hormone during the estrous cycle. Previous researches showed that the FecB mutation can regulate the transcriptomic profiles in the reproductive-related tissues including hypothalamus, pituitary, and ovary during the estrous cycle of small-tailed Han (STH) sheep...
December 5, 2023: G3: Genes—Genomes—Genetics
keyword
keyword
1919
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.