keyword
https://read.qxmd.com/read/38491797/lncrna-mrak052509-competitively-adsorbs-mir-204-3p-to-regulate-silica-dust-induced-emt-process
#1
JOURNAL ARTICLE
Liu Xuan, Jiao Zi-Ming, Tian Xue-Yan, Hu Wen-Xuan, Wang Fa-Xuan
Silicosis is a systemic disease caused by long-term inhalation of free SiO2 and retention in the lungs. At present, it is still the most important occupational health hazard disease in the world. Existing studies have shown that non-coding RNA can also participate in complex fibrosis regulatory networks. However, its role in regulating silicotic fibrosis is still unclear. In this study, we constructed a NR8383/RLE-6TN co-culture system to simulate the pathogenesis of silicosis in vitro. Design of miR-204-3p mimics and inhibitors to overexpress or downregulate miR-204-3p in RLE-6TN cells...
March 16, 2024: Environmental Toxicology
https://read.qxmd.com/read/38461204/the-potential-of-targeting-autophagy-related-non-coding-rnas-in-the-treatment-of-alzheimer-s-and-parkinson-s-diseases
#2
REVIEW
Abdolkarim Talebi Taheri, Zakieh Golshadi, Hamidreza Zare, Azam Alinaghipour, Zahra Faghihi, Ehsan Dadgostar, Zeinab Tamtaji, Michael Aschner, Hamed Mirzaei, Omid Reza Tamtaji, Fatemeh Nabavizadeh
Clearance of accumulated protein aggregates is one of the functions of autophagy. Recently, a clearer understanding of non-coding RNAs (ncRNAs) functions documented that ncRNAs have important roles in several biological processes associated with the development and progression of neurodegenerative disorders. Subtypes of ncRNA, including microRNA (miRNA), long noncoding RNA (lncRNA), and circular RNA (circRNA), are commonly dysregulated in neurodegenerative disorders such as Alzheimer and Parkinson diseases...
March 10, 2024: Cellular and Molecular Neurobiology
https://read.qxmd.com/read/38460130/a-therapeutically-targetable-positive-feedback-loop-between-lnc-hlx-2-7-hlx-and-myc-that-promotes-group-3-medulloblastoma
#3
JOURNAL ARTICLE
Keisuke Katsushima, Kandarp Joshi, Menglang Yuan, Brigette Romero, Mona Batish, Stacie Stapleton, George Jallo, Elayaraja Kolanthai, Sudipta Seal, Olivier Saulnier, Michael D Taylor, Robert J Wechsler-Reya, Charles G Eberhart, Ranjan J Perera
Recent studies suggest that long non-coding RNAs (lncRNAs) contribute to medulloblastoma (MB) formation and progression. We have identified an lncRNA, lnc-HLX-2-7, as a potential therapeutic target in group 3 (G3) MBs. lnc-HLX-2-7 RNA specifically accumulates in the promoter region of HLX, a sense-overlapping gene of lnc-HLX-2-7, which activates HLX expression by recruiting multiple factors, including enhancer elements. RNA sequencing and chromatin immunoprecipitation reveal that HLX binds to and activates the promoters of several oncogenes, including TBX2, LIN9, HOXM1, and MYC...
March 8, 2024: Cell Reports
https://read.qxmd.com/read/38449593/decreased-expression-of-h19-mir-675-ameliorates-hypoxia-induced-oxaliplatin-resistance-in-colorectal-cancer
#4
JOURNAL ARTICLE
Xingyue Weng, Tao Ma, Qi Chen, Bryan Wei Chen, Jianzhen Shan, Wei Chen, Xiao Zhi
Hypoxic microenvironment, a hallmark of solid tumors, contributes to chemoresistance, and long noncoding (lnc) RNAs are involved in hypoxia-induced drug resistance. However, the role of lncRNAs in hypoxic tumor chemotherapy resistance remains unclear. Here, we aimed to elucidate the effects of lncRNAs in hypoxia-mediated resistance in colorectal cancer (CRC), as well as the underlying mechanisms. The results indicated that the expression of lncRNA H19 was enhanced in hypoxia- or oxaliplatin-treated CRC cells; moreover, H19 contributed to drug resistance in CRC cells both in vitro and in vivo...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38443115/pervasive-translation-of-xrn1-sensitive-unstable-long-non-coding-rnas-in-yeast
#5
JOURNAL ARTICLE
Sara Andjus, Ugo Szachnowski, Nicolas Vogt, Stamatia Gioftsidi, Isabelle Hatin, David Cornu, Chris Papadopoulos, Anne Lopes, Olivier Namy, Maxime Wery, Antonin Morillon
Despite being predicted to lack coding potential, cytoplasmic long non-coding (lnc)RNAs can associate with ribosomes. However, the landscape and biological relevance of lncRNAs translation remains poorly studied. In yeast, cytoplasmic Xrn1-sensitive lncRNAs (XUTs) are targeted by the Nonsense-Mediated mRNA Decay (NMD), suggesting a translation-dependent degradation process. Here, we report that XUTs are pervasively translated, which impacts their decay. We show that XUTs globally accumulate upon translation elongation inhibition, but not when initial ribosome loading is impaired...
March 5, 2024: RNA
https://read.qxmd.com/read/38432129/sense-and-anti-sense-role-of-fam83a-and-fam83a-as1-in-wnt-egfr-pi3k-emt-pathways-and-tumor-progression
#6
REVIEW
Chenshu Zhao, Xiaowen Li, Rui Zhang, Hao Lyu, Shuai Xiao, Dong Guo, Declan William Ali, Marek Michalak, Xing-Zhen Chen, Cefan Zhou, Jingfeng Tang
An increasing number of studies have shown that FAM83A, a member of the family with sequence similarity 83 (FAM83), which consists of eight members, is a key tumor therapeutic target involved in multiple signaling pathways. It has been reported that FAM83A plays essential roles in the regulation of Wnt/β-catenin, EGFR, MAPK, EMT, and other signaling pathways and physiological processes in models of pancreatic cancer, lung cancer, breast cancer, and other malignant tumors. Moreover, the expression of FAM83A could be significantly affected by multiple noncoding RNAs that are dysregulated in malignant tumors, the dysregulation of which is essential for the malignant process...
March 2, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38426536/m6a-methyltransferase-mettl14%C3%A2-mediated-rp1%C3%A2-228h13-5-promotes-the-occurrence-of-liver-cancer-by-targeting-hsa%C3%A2-mir%C3%A2-205-zik1
#7
JOURNAL ARTICLE
Jia Xu, Chang Liu, Kai Qu, Jingyao Zhang, Sinan Liu, Fandi Meng, Yong Wan
The aim of the present study was to explore the association between N6 ‑methyladenosine (m6A) modification regulatory gene‑related long noncoding (lnc)RNA RP1‑228H13.5 and cancer prognosis through bioinformatics analysis, as well as the impact of RP1‑228H13.5 on cell biology‑related behaviors and specific molecular mechanisms. Bioinformatics analysis was used to construct a risk model consisting of nine genes. This model can reflect the survival time and differentiation degree of cancer...
April 2024: Oncology Reports
https://read.qxmd.com/read/38393488/pleomorphic-adenoma-with-a-novel-gene-rearrangement-linc01606-plag1
#8
REVIEW
Udit Naik, Sara E Amin, Mahmoud Elsayad, Karan Saluja
BACKGROUND: Pleomorphic adenoma is a well-known benign salivary gland neoplasm characterized by the presence of varying proportions of three different components, including bi-layered ducts, myoepithelial cells, and admixed within a chondromyxoid/fibrous stroma. METHOD: We report an interesting case of an adult male who presented with bleeding from an extensively degenerated parotid gland mass, concerning for a vascular neoplasm versus primary malignant tumor. Microscopically, majority of the viable tumor exhibited diffuse proliferation of spindle to epithelioid cells, with focal areas depicting cribriform glands, ducts, and scant chondromyxoid stroma...
February 23, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38392967/functional-relevance-of-extracellular-vesicle-derived-long-non-coding-and-circular-rnas-in-cancer-angiogenesis
#9
REVIEW
José A Peña-Flores, Daniela Muela-Campos, Rebeca Guzmán-Medrano, Diego Enríquez-Espinoza, Karla González-Alvarado
Extracellular vesicles (EVs) are defined as subcellular structures limited by a bilayer lipid membrane that function as important intercellular communication by transporting active biomolecules, such as proteins, amino acids, metabolites, and nucleic acids, including long non-coding RNAs (lncRNAs). These cargos can effectively be delivered to target cells and induce a highly variable response. LncRNAs are functional RNAs composed of at least 200 nucleotides that do not code for proteins. Nowadays, lncRNAs and circRNAs are known to play crucial roles in many biological processes, including a plethora of diseases including cancer...
February 6, 2024: Non-Coding RNA
https://read.qxmd.com/read/38389521/evaluation-of-the-expression-of-infection-related-long-noncoding-rnas-among-covid-19-patients-a-case-control-study
#10
JOURNAL ARTICLE
Zahra Firoozi, Elham Mohammadisoleimani, Farzaneh Bagheri, Atefeh Taheri, Babak Pezeshki, Mohammad Mehdi Naghizadeh, Abdolreza Daraei, Jalal Karimi, Yousef Gholampour, Yaser Mansoori, Zahra Montaseri
BACKGROUND AND AIMS: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a worldwide pandemic, activates signaling cascades and leads to innate immune responses and secretion of multiple chemokines and cytokines. Long noncoding RNAs (lncRNAs) have a crucial role in inflammatory pathways. Through our search on the PubMed database, we discovered that existing research has primarily focused on examining the regulatory impacts of five lncRNAs in the context of viral infections. However, their role in regulating other conditions, including SARS-CoV-2, has not been explored...
2024: Genetics Research
https://read.qxmd.com/read/38388775/the-long-non-coding-rna-nr3c2-8-1-promotes-p53-mediated-apoptosis-through-the-mir-129-5p-usp10-axis-in-amyotrophic-lateral-sclerosis
#11
JOURNAL ARTICLE
Dejiang Pang, Yujiao Yu, Bi Zhao, Jingxuan Huang, Yiyuan Cui, Tengfei Li, Chunyu Li, Huifang Shang
Motor neuron degeneration in amyotrophic lateral sclerosis (ALS) is a form of apoptosis, but the mechanisms underlying this neuronal cell death remain unclear. Numerous studies demonstrate abnormally elevated and active p53 in the central nervous system of ALS patients. Activation of p53-regulated pro-apoptotic signaling pathways may trigger motor neuron death. We previously reported decreased expression of the long non-coding RNA NR3C2-8:1 (Lnc-NR3C) in leukocytes of ALS patients. Here, we show lnc-NR3C promotes p53-mediated cell death in ALS by upregulating USP10 and promoting lnc-NR3C-triggered p53 activation, resulting in cell death...
February 23, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38387756/lnc-plcb1-is-stabilized-by-mettl14-induced-m6a-modification-and-inhibits-helicobacter-pylori-mediated-gastric-cancer-by-destabilizing-ddx21
#12
JOURNAL ARTICLE
Mingjie Chang, Qiyu Sun, Xixi Cui, Yuqiong Wang, Jiayi Liu, Zenghui Sun, Juchao Ren, Yundong Sun, Lihui Han, Wenjuan Li
Helicobacter pylori (H. pylori) infection is considered to be an important factor in gastric cancer (GC). Long noncoding RNA (lncRNA) and m6A modification are involved in the occurrence and development of GC, but the role of lncRNA m6A modification in the development of GC mediated by H. pylori is still unclear. Here, we found that H. pylori infection downregulated the expression of lnc-PLCB1 through METTL14-mediated m6A modification and IRF2-mediated transcriptional regulation. Overexpression of lnc-PLCB1 inhibited the proliferation and migration of GC cells, while downregulation of lnc-PLCB1 promoted the proliferation and migration ability of GC cells...
February 20, 2024: Cancer Letters
https://read.qxmd.com/read/38383230/the-grhl3-regulated-long-non-coding-rna-lnc-dc-modulates-keratinocytes-differentiation-by-interacting-with-igf2bp2-and-up-regulating-znf750
#13
JOURNAL ARTICLE
Xue-Ting Hu, Xiao-Feng Wu, Lu-Min Sui, Luo-Quan Ao, Cheng-Xiu Pu, Mu Yuan, Wei Xing, Xiang Xu
BACKGROUND: Aberrant keratinocytes differentiation has been demonstrated to be associated with a number of skin diseases. The roles of lncRNAs in keratinocytes differentiation remain to be largely unknown. OBJECTIVE: Here we aim to investigate the role of lnc-DC in regulating epidermal keratinocytes differentiation. METHODS: Expression of lnc-DC in the skin was queried in AnnoLnc and verified by FISH. The lncRNA expression profiles during keratinocytes differentiation were reanalyzed and verified by qPCR and FISH...
February 12, 2024: Journal of Dermatological Science
https://read.qxmd.com/read/38376452/identification-and-verification-on-prognostic-index-of-glioblastoma-immune-related-lncrnas
#14
JOURNAL ARTICLE
Guofu Zheng, Qingsong Jiang, Cai Jiang, Xingxin Zhu, Yongjie Wang
BACKGROUND: Glioblastoma (GBM) is the most common cause of primary brain malignancy. Recently, many immune-related long noncoding ribonucleic acids (ir-lncRNAs) are indicated to be closely related to the regulation of the immune microenvironment and immune cell infiltration of GBM. OBJECTIVES: Through the joint analysis of multiple public databases, key ir-lncRNAs in GBM were screened. The ir-lncRNAs were used to construct risk-scoring models and promote the development of novel GBM biomarkers...
February 20, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/38368122/lncrnas-the-art-of-being-influential-without-protein
#15
REVIEW
Lorena Ramírez Gonzales, Suze Blom, Rossana Henriques, Christian W B Bachem, Richard G H Immink
The plant long noncoding (lnc)RNA field is on the brink of transitioning from large-scale identification of lncRNAs to their functional characterization. Due to the cross-kingdom conservation of interaction types and molecular functions, there is much to be learned from mammalian lncRNA research. Here, we discuss the different molecular processes involving lncRNAs from the regulation of chromatin to splicing. Furthermore, we discuss the lncRNA interactome, which includes proteins, other RNAs, and DNA. We explore and discuss how mammalian lncRNA functionalities could be reflected in similar pathways in plants and hypothesize that several breakthroughs in mammalian research could lead to the discovery of novel plant lncRNA molecular functions...
February 16, 2024: Trends in Plant Science
https://read.qxmd.com/read/38360831/silver-nanoparticle-functionalized-by-glutamine-and-conjugated-with-thiosemicarbazide-induces-apoptosis-in-colon-cancer-cell-line
#16
JOURNAL ARTICLE
Hadi Taati, Helia Sangani, Arash Davoudi, Samira Safabakhsh Kouchesfahani, Mohammad Hedayati, Sana Tarashandeh Hemmati, Taraneh Ghasemipour, Shahrzad Aghajani, Mahan Farah Andooz, Maryam Amanollahi, Fakhrieh Kalavari, Ali Salehzadeh
The high mortality rate of colon cancer indicates the insufficient efficacy of current chemotherapy. Thus, the discussion on engineered metal nanoparticles in the treatment of the disease has been considered. In this study, silver nanoparticles were functionalized with glutamine and conjugated with thiosemiccarbazide. Then, anticancer mechanism of Ag@Gln-TSC NPs in a colon cancer cell line (SW480) was investigated. Characterizing Ag@Gln-TSC NPs by FT-IR, XRD, EDS-mapping, DLS, zeta potential, and SEM and TEM microscopy revealed that the Ag@Gln-TSC NPs were correctly synthesized, the particles were spherical, with surface charge of - 27...
February 15, 2024: Scientific Reports
https://read.qxmd.com/read/38356866/lnc-ccnh-8-promotes-immune-escape-by-up-regulating-pd-l1-in-hepatocellular-carcinoma
#17
JOURNAL ARTICLE
Bixing Zhao, Xiaoyuan Zheng, Yang Wang, Niangmei Cheng, Yue Zhong, Yang Zhou, Jingyun Huang, Fei Wang, Xin Qi, Qiuyu Zhuang, Yingchao Wang, Xiaolong Liu
Hepatocellular carcinoma (HCC) is a common malignancy with poor prognosis. In recent years, immune checkpoint inhibitors (ICIs) have enabled breakthroughs in the clinical treatment of patients with HCC, but the overall response rate to ICIs in HCC patients is still low, and no validated biomarker is available to guide clinical decision making. Here, we demonstrated that the long non-coding RNA Lnc-CCNH-8 is highly expressed in HCC and correlates with poor prognosis. Functionally, elevated Lnc-CCNH-8 inactivated co-cultured T cells in vitro and compromised antitumor immunity in an immunocompetent mouse model...
March 12, 2024: Molecular Therapy. Nucleic Acids
https://read.qxmd.com/read/38356713/lnc-clstn2-1-1-promotes-osteosarcoma-progression-by-disrupting-redox-balance-through-pi3k-akt-signaling-pathway
#18
JOURNAL ARTICLE
Hao Lin, Xinjian Wei, Junhong Ye, Jiaxian Chen, Jing Huang, Tingrui Wu, Zhenju Chen, Yuming Zeng, Lijiao Peng
Objective: Most patients with osteosarcoma (OS) have an extremely poor prognosis. The primary purpose of this investigation was to explore the biological effect of Lnc-CLSTN2-1:1 on OS and the potential processes involved. Materials and procedures: We selected differentially overexpressed Lnc-CLSTN2-1:1 from our laboratory's existing RNA sequence analysis data (fibroblast osteoblast (hFOB 1.19) and three osteosarcoma cell lines (HOS, MG63, and U2OS) as the research object. Next, we detected Lnc-CLSTN2-1:1 in the osteosarcoma HOS cell line and fibroblast cells using qRT-PCR...
2024: Journal of Cancer
https://read.qxmd.com/read/38341118/long-noncoding-rna-expression-in-acute-lymphoblastic-leukemia-a-systematic-review
#19
REVIEW
Sara Cristina Lobo-Alves, Liana Alves de Oliveira, Gabriela Canalli Kretzschmar, Andressa Eloisa Valengo, Roberto Rosati
Long noncoding RNAs (lncRNAs), as gene expression modulators, are potential players in Acute Lymphoblastic Leukemia (ALL) pathogenesis. We systematically explored current literature on lncRNA expression in ALL to identify lncRNAs consistently reported as differentially expressed (DE) either in ALL versus controls or between ALL subtypes. By comparing articles that provided global expression data for DE lncRNAs in the ETV6::RUNX1-positive ALL subtype, we identified four DE lncRNAs in three independent studies (two versus other subtypes and one versus controls), showing concordant expression of LINC01013, CRNDE and lnc-KLF7-1...
February 8, 2024: Critical Reviews in Oncology/hematology
https://read.qxmd.com/read/38326863/the-epigenetic-downregulation-of-lncghrlos-mediated-by-rna-m6a-methylase-zcchc4-promotes-colorectal-cancer-tumorigenesis
#20
JOURNAL ARTICLE
Ke Chen, Jingcheng Zhang, Lei Meng, Lingshang Kong, Ming Lu, Zhengguang Wang, Wenbin Wang
BACKGROUND: m6A modification is currently recognized as a major driver of RNA function that maintains cancer cell homeostasis. Long non-coding (Lnc) RNAs control cell proliferation and play an important role in the occurrence and progression of colorectal cancer (CRC). ZCCHC4 is a newly discovered m6A methyltransferase whose role and mechanism in tumors have not yet been elucidated. METHODS: The EpiQuik m6A RNA methylation kit was used to detect the level of total RNA m6A in six types of digestive tract tumors...
February 7, 2024: Journal of Experimental & Clinical Cancer Research: CR
keyword
keyword
1919
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.