Cheng Sun, Chan Zhou, Kaveh Daneshvar, Amel Ben Saad, Arcadia J Kratkiewicz, Benjamin J Toles, Nahid Arghiani, Anja Hess, Jennifer Y Chen, Joshua V Pondick, Samuel R York, Wenyang Li, Sean Moran, Stefan Gentile, Raza Ur Rahman, Zixiu Li, Peng Zhou, Robert Sparks, Tim Habboub, Byeong-Moo Kim, Michael Y Choi, Silvia Affo, Robert F Schwabe, Yury V Popov, Alan C Mullen
BACKGROUND AND AIMS: Fibrosis is the common endpoint for all forms of chronic liver injury, and progression of fibrosis leads to the development of end-stage liver disease. Activation of hepatic stellate cells (HSCs) and their transdifferentiation into myofibroblasts results in the accumulation of extracellular matrix (ECM) proteins that form the fibrotic scar. Long noncoding (lnc) RNAs regulate the activity of HSCs and provide targets for fibrotic therapies. APPROACH AND RESULTS: We identified lncRNA TILAM located near COL1A1, expressed in HSCs, and induced with liver fibrosis in humans and mice...
April 2, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases