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Lnc RNA

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https://www.readbyqxmd.com/read/28528185/simvastatin-ameliorate-memory-deficits-and-inflammation-in-clinical-and-mouse-model-of-alzheimer-s-disease-via-modulating-the-expression-of-mir-106b
#1
Wenzhong Huang, Zhenyu Li, Liandong Zhao, Wei Zhao
BACKGROUND: Alzheimer's disease (AD) as a neurodegenerative brain disorder is a devastating pathology leading to disastrous cognitive impairments and dementia, and several studies have shown that AD is closely related to the inflammation, so anti-inflammatory treatment may provide therapeutic benefits. In this study, the effect of simvastatin on inflammation was investigated and the underlying mechanisms were explored. METHODS: First, we tested the effect of simvastatin on AD in clinical research...
May 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28507479/knockdown-of-lncrna-pandar-suppresses-the-proliferation-cell-cycle-and-promotes-apoptosis-in-thyroid-cancer-cells
#2
Zhirong Li, Bo Gao, Shuai Hao, Wuguo Tian, Yi Chen, Lingli Wang, Xiaohua Zhang, Donglin Luo
Long non-coding RNAs (lncRNAs) have been found to show important regulatory roles in various human cancers. Lnc-RNA PANDAR is a novel identified lncRNA that was previously reported to show abnormal expression pattern in various cancers. However, little is known of its expression and biological function in thyroid cancer. Here, we used the quantitative real-time PCR (qRT-PCR) to determine the expression of PANDAR in 64 thyroid cancer tissues. We found that expression of PANDAR was up-regulated in thyroid cancer tissues compared with adjacent non-tumor tissues...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28502821/sasp-regulation-by-noncoding-rna
#3
REVIEW
Amaresh C Panda, Kotb Abdelmohsen, Myriam Gorospe
Noncoding RNAs (ncRNAs), including micro (mi)RNAs, long noncoding (lnc)RNAs, and circular (circ)RNAs, control specific gene expression programs by regulating transcriptional, post-transcriptional, and post-translational processes. Through their broad influence on protein expression and function, ncRNAs have been implicated in virtually all cellular processes such as proliferation, senescence, quiescence, differentiation, apoptosis, and the stress and immune responses. Senescence is a cellular phenotype associated with the physiologic decline of aging and with age-related pathologies...
May 11, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28450531/thousands-of-rna-cached-copies-of-whole-chromosomes-are-present-in-the-ciliate-oxytricha-during-development
#4
Kelsi A Lindblad, John R Bracht, April E Williams, Laura Landweber
The ciliate Oxytricha trifallax maintains two genomes: a germline genome that is active only during sexual conjugation and a transcriptionally active, somatic genome that derives from the germline via extensive sequence reduction and rearrangement. Previously, we found that long, non-coding (lnc) RNA "templates" - telomere-containing, RNA-cached copies of mature chromosomes - provide the information to program the rearrangement process. Here we used a modified RNA-seq approach to conduct the first genome-wide search for endogenous, telomere-to-telomere RNA transcripts in any eukaryotic genome...
April 27, 2017: RNA
https://www.readbyqxmd.com/read/28446531/mining-exosomal-genes-for-pancreatic-cancer-targets
#5
Amy Makler, Ramaswamy Narayanan
BACKGROUND: Exosomes, cell-derived vesicles encompassing lipids, DNA, proteins coding genes and noncoding RNAs (ncRNAs) are present in diverse body fluids. They offer novel biomarker and drug therapy potential for diverse diseases, including cancer. MATERIALS AND METHODS: Using gene ontology, exosomal genes database and GeneCards metadata analysis tools, a database of cancer-associated protein coding genes and ncRNAs (n=2,777) was established. Variant analysis, expression profiling and pathway mapping were used to identify putative pancreatic cancer exosomal gene candidates...
May 2017: Cancer Genomics & Proteomics
https://www.readbyqxmd.com/read/28420760/novel-lnc-rna-regulated-by-hif-1-inhibits-apoptotic-cell-death-in-the-renal-tubular-epithelial-cells-under-hypoxia
#6
Imari Mimura, Yosuke Hirakawa, Yasuharu Kanki, Natsuki Kushida, Ryo Nakaki, Yutaka Suzuki, Tetsuhiro Tanaka, Hiroyuki Aburatani, Masaomi Nangaku
Chronic tubulointerstitial hypoxia plays an important role as the final common pathway to end-stage renal disease. HIF-1 (hypoxia-inducible factor-1) is a master transcriptional factor under hypoxia, regulating downstream target genes. Genome-wide analysis of HIF-1 binding sites using high-throughput sequencers has clarified various kinds of downstream targets and made it possible to demonstrate the novel roles of HIF-1. Our aim of this study is to identify novel HIF-1 downstream epigenetic targets which may play important roles in the kidney...
April 2017: Physiological Reports
https://www.readbyqxmd.com/read/28413461/long-noncoding-rna-malat1-inhibits-apoptosis-induced-by-oxygen-glucose-deprivation-and-reoxygenation-in-human-brain-microvascular-endothelial-cells
#7
Jia-Wei Xin, Yu-Gang Jiang
Cerebral ischemia/reperfusion (I/R) injury leads to brain vascular dysfunction, which is characterized by endothelial cell injury or death. Long noncoding (lnc) RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is reportedly associated with endothelial cell functions and dysfunctions. In the present study, the role of MALAT1 in I/R-induced cerebral vascular endothelial cell apoptosis was explored using oxygen-glucose deprivation and reoxygenation (OGD-R) as an in vitro I/R injury model. Primary human brain microvascular endothelial cells were cultured under OGD-R, and the expression levels of MALAT1 and cell apoptosis were measured at 6, 9, 12, 24 and 36 h post-reoxygenation...
April 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28371600/hur-stabilizes-lnc-sox5-mrna-to-promote-tongue-carcinogenesis
#8
Lifang Wang, Shucheng Ye, Junye Wang, Zhenfang Gu, Yanhui Zhang, Chunmei Zhang, Xuezhen Ma
Long noncoding RNAs (lncRNAs) have been recently regarded as systemic regulators in multiple biological processes including tumorigenesis. In this study, we report an ultra-highly expressed lncRNA, lnc-Sox5, in tongue tumor tissues. The results imply that lnc-Sox5 may play vital role in tongue carcinoma progression. We observed that the growth of Tca8113 cells was suppressed by lnc-Sox5 downregulation. Additionally, lnc-Sox5 knockdown simultaneously increased Tca8113 cell apoptosis, but the cell cycle was arrested...
April 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28341852/profiling-of-long-non-coding-rnas-identifies-linc00958-and-linc01296-as-candidate-oncogenes-in-bladder-cancer
#9
Anna Katharina Seitz, Lise Lotte Christensen, Emil Christensen, Kasper Faarkrog, Marie Stampe Ostenfeld, Jakob Hedegaard, Iver Nordentoft, Morten Muhlig Nielsen, Johan Palmfeldt, Michelle Thomson, Michael Theis Solgaard Jensen, Roman Nawroth, Tobias Maurer, Torben Falck Ørntoft, Jørgen Bjerggaard Jensen, Christian Kroun Damgaard, Lars Dyrskjøt
Aberrant expression of long non-coding RNAs (lncRNAs) has been regarded as a critical component in bladder cancer (BC) and lncRNAs have been associated with BC development and progression although their overall expression and functional significance is still unclear. The aim of our study was to identify novel lncRNAs with a functional role in BC carcinogenesis. RNA-sequencing was used to identify aberrantly expressed lncRNAs in 8 normal and 72 BC samples. We identified 89 lncRNAs that were significantly dys-regulated in BC...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28281528/lnc-mg-is-a-long-non-coding-rna-that-promotes-myogenesis
#10
Mu Zhu, Jiafan Liu, Jia Xiao, Li Yang, Mingxiang Cai, Hongyu Shen, Xiaojia Chen, Yi Ma, Sumin Hu, Zuolin Wang, An Hong, Yingxian Li, Yao Sun, Xiaogang Wang
Recent studies indicate important roles for long noncoding RNAs (lncRNAs) as essential regulators of myogenesis and adult skeletal muscle regeneration. However, the specific roles of lncRNAs in myogenic differentiation of adult skeletal muscle stem cells and myogenesis are still largely unknown. Here we identify a lncRNA that is specifically enriched in skeletal muscle (myogenesis-associated lncRNA, in short, lnc-mg). In mice, conditional knockout of lnc-mg in skeletal muscle results in muscle atrophy and the loss of muscular endurance during exercise...
March 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/28252643/2-o-methylmagnolol-upregulates-the-long-non-coding-rna-gas5-and-enhances-apoptosis-in-skin-cancer-cells
#11
Tong-Hong Wang, Chieh-Wen Chan, Jia-You Fang, Ya-Min Shih, Yi-Wen Liu, Tzu-Chien V Wang, Chi-Yuan Chen
Magnolol, a hydroxylated biphenol compound isolated from the bark of Magnolia officinalis, has been shown to exhibit anti-proliferative effect in various cancer cells, including skin cancer cells. Methoxylation of magnolol appears to improve its anti-inflammatory activity, yet the effect of this modification on the agent's antitumor activity remains unknown. In this work, we report that 2-O-methylmagnolol (MM1) displays improved antitumor activity against skin cancer cells compared to magnolol both in vitro and in vivo...
March 2, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28249151/induction-of-the-long-noncoding-rna-nbr2-from-the-bidirectional-brca1-promoter-under-hypoxic-conditions
#12
J Erin Wiedmeier, Anna Ohlrich, Adrian Chu, Michael R Rountree, Mitchell S Turker
BRCA1 plays an important role in preventing breast cancer and is often silenced or repressed in sporadic cancer. The BRCA1 promoter is bidirectional: it drives transcription of the long non-coding (lnc) NBR2 transcript in the opposite orientation relative to the BRCA1 transcript. Hypoxic conditions repress BRCA1 transcription, but their effect on expression of the NBR2 transcript has not been reported. We used quantitative RT-PCR to measure BRCA1 and NBR2 transcript levels in 0% and 1% oxygen in MCF-7 breast cancer cells and found that NBR2 transcript levels increased as a function of time under hypoxic conditions, whereas BRCA1 mRNA levels were repressed...
February 2017: Mutation Research
https://www.readbyqxmd.com/read/28206970/genetic-variation-in-long-noncoding-rnas-and-the-risk-of-nonalcoholic-fatty-liver-disease
#13
Silvia Sookoian, Cristian Rohr, Adrián Salatino, Hernán Dopazo, Tomas Fernandez Gianotti, Gustavo O Castaño, Carlos J Pirola
The human transcriptome comprises a myriad of non protein-coding RNA species, including long noncoding RNAs (lncRNAs), which have a remarkable role in transcriptional and epigenetic regulation. We hypothesized that variants in lncRNAs influence the susceptibility to nonalcoholic fatty liver disease (NAFLD). Using next generation sequencing, we performed a survey of genetic variation associated with randomly selected lncRNA-genomic regions located within both experimentally validated and computationally predicted regulatory elements...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28195197/let-7e-modulates-the-inflammatory-response-in-vascular-endothelial-cells-through-cerna-crosstalk
#14
Zongwei Lin, Junfeng Ge, Zhe Wang, Jianwei Ren, Xiaowei Wang, Hui Xiong, Jing Gao, Yan Zhang, Qunye Zhang
The inflammatory responses of vascular endothelial cells (VECs) are critical in the development of many cardio-cerebrovascular diseases. Let-7e is an important regulator of endothelial function and inflammation. However, the effects and mechanisms of let-7e on VECs inflammation have not been studied until recently. Thus, we investigated these issues and found that in addition to proliferation, apoptosis and cell adhesion, let-7e was also implicated in the regulation of inflammatory responses through a complex network, including IκBβ and lncRNA lnc-MKI67IP-3...
February 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28189050/h19-overexpression-induces-resistance-to-1-25-oh-2d3-by-targeting-vdr-through-mir-675-5p-in-colon-cancer-cells
#15
Shanwen Chen, Dingfang Bu, Yuanyuan Ma, Jing Zhu, Guowei Chen, Lie Sun, Shuai Zuo, Tengyu Li, Yisheng Pan, Xin Wang, Yucun Liu, Pengyuan Wang
The long noncoding (lnc) RNA H19 was involved in the tumorigenesis of many types of cancer. However, the role of H19 in the tumorigenesis of colon cancer has not been fully illustrated. Recent studies suggested a potential relationship between H19 and vitamin D receptor (VDR) signaling. Considering the pivotal role of VDR signaling in the colon epithelium both physiologically and pathologically, the correlation between H19 and VDR signaling may have an important role in the development of colon cancer. In this study, the correlation between H19 and vitamin D receptor (VDR) signaling and the underlying mechanisms in colon cancer were investigated both in vitro and in vivo...
March 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28185352/lnc-dc-mediates-the-over-maturation-of-decidual-dendritic-cells-and-induces-the-increase-in-th1-cells-in-preeclampsia
#16
Wen Zhang, Yang Zhou, YiLing Ding
PROBLEM: Preeclampsia is a severe pregnancy-related disease that involves an imbalance of the immune reaction, which is dominated by T helper1 (Th1) cells; however, the mechanism is unclear. METHOD OF STUDY: We used flow cytometry, RT-PCR and western blotting to detect Th1 cells in the blood and mature dendritic cells, lnc-DC (a long non-coding RNA that is specifically expressed in DCs and can mediate dendritic cell maturation by phosphorylating STAT3) and p-STAT3 (phosphorylated transducer and activator of transcription 3) in the deciduas of normal pregnancies and preeclampsia patients...
February 10, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28174058/the-expression-of-lnc-il-7r-long-non-coding-rna-dramatically-correlated-with-soluble-and-membrane-bound-isoforms-of-il-7ra-gene-in-multiple-sclerosis-patients
#17
Parinaz Bina, Majid Pahlevan Kakhki, Mohammad Ali Sahraian, Mehrdad Behmanesh
BACKGROUND AND PURPOSE: Multiple sclerosis (MS) is a neurological disease of the central nervous system (CNS) that causes physical and cognitive impairments. IL-7Ra is a key non-MHC gene associated with MS. IL-7Ra is a likely functional candidate for this complex disease because it is involved in the development, maturation, and homeostasis of T and B cells. Our aim was to evaluate the expression level and controlling role of lnc-IL-7R in the expression of two variants of IL-7Ra in MS patients versus healthy controls and their correlation with certain clinical features...
March 6, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28138030/the-tlr3-agonist-inhibit-drug-efflux-and-sequentially-consolidates-low-dose-cisplatin-based-chemoimmunotherapy-while-reducing-side-effects
#18
Liang Ding, Jing Ren, Dongya Zhang, Yi Li, XiaoFeng Huang, Jianjian Ji, Qingang Hu, Hui Wang, Yanhong Ni, Yayi Hou
The traditional maximum dose density chemotherapy renders the tumor patients not only the tumor remission but the chemotherapy resistance and more adverse side effects. According to the widely positive expression of Toll-like receptor (TLR)-3 in oral squamous cell carcinoma (OSCC) patients (n=166), we here provided an alternative strategy involved the orderly treatment of TLR3 agonist polyinosine-polycytidylic acid (PIC) and low-dose cisplatin. The optimal dose of cisplatin, the novel role of PIC and the side effects of the combined chemotherapy were determined in vitro and in distinct human tumor models in vivo...
January 30, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28115163/lnc-atb-contributes-to-gastric-cancer-growth-through-a-mir-141-3p-tgf%C3%AE-2-feedback-loop
#19
Kecheng Lei, Xin Liang, Yuwei Gao, Baixue Xu, Yichun Xu, Yueqi Li, Yiwen Tao, Weibin Shi, Jianwen Liu
The long noncoding RNA (lncRNA) ATB is an important regulator in human tumors. Here, we aimed to investigate the potential molecular mechanisms of lnc-ATB in gastric cancer (GC) tumorigenesis. RT-qPCR analysis was used to detect lnc-ATB expression level in 20 pairs of gastric cancer tissues and adjacent normal gastric mucosa tissues (ANTs). Moreover, the biological role of lnc-ATB was determined in vitro. We found that lnc-ATB was significantly upregulated in GC tissues compared to lnc-ATB expression in ANTs...
March 11, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28111341/dysregulation-of-long-noncoding-rnas-in-mouse-testes-and-spermatozoa-after-exposure-to-cadmium
#20
Fengxin Gao, Peng Zhang, Hongyan Zhang, Yunhui Zhang, Yunwen Zhang, Qingyun Hao, Xiaoning Zhang
There is increasing evidence that cadmium (Cd) exposure can cause male subfertility and even complete infertility in mammals. Long noncoding (lnc) RNAs are critical for spermatogenesis, and their dysregulation might lead to male infertility. However, whether they are involved in Cd-induced subfertility is unknown. Here we found that intraperitoneal exposure to Cd in mice led to male subfertility indicated by reductions in testicular sperm production and motility, and by abnormal morphology. Testicular and sperm RNAs were used to investigate lncRNA expression profiles by strand-specific RNA sequencing at the transcriptome level to help determine any RNA-related mechanisms in Cd-induced subfertility...
January 19, 2017: Biochemical and Biophysical Research Communications
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