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https://www.readbyqxmd.com/read/29449542/long-non-coding-rnas-in-ischemic-stroke
#1
REVIEW
Mei-Hua Bao, Vivian Szeto, Burton B Yang, Shu-Zhen Zhu, Hong-Shuo Sun, Zhong-Ping Feng
Stroke is one of the leading causes of mortality and disability worldwide. Uncovering the cellular and molecular pathophysiological processes in stroke have been a top priority. Long non-coding (lnc) RNAs play critical roles in different kinds of diseases. In recent years, a bulk of aberrantly expressed lncRNAs have been screened out in ischemic stroke patients or ischemia insulted animals using new technologies such as RNA-seq, deep sequencing, and microarrays. Nine specific lncRNAs, antisense non-coding RNA in the INK4 locus (ANRIL), metastasis-associate lung adenocarcinoma transcript 1 (MALAT1), N1LR, maternally expressed gene 3 (MEG3), H19, CaMK2D-associated transcript 1 (C2dat1), Fos downstream transcript (FosDT), small nucleolar RNA host gene 14 (SNHG14), and taurine-upregulated gene 1 (TUG1), were found increased in cerebral ischemic animals and/or oxygen-glucose deprived (OGD) cells...
February 15, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29428796/long-noncoding-rna-growth-arrest-specific-5-promotes-proliferation-and-survival-of-female-germline-stem-cells-in-vitro
#2
Jie Wang, Xiaowen Gong, Geng G Tian, Changliang Hou, Xiaoqin Zhu, Xiuying Pei, Yanrong Wang, Ji Wu
Female germline stem cells (FGSCs) are proposed to be a key factor for ameliorating female infertility. Previously we have shown that neonatal and adult FGSCs could be isolated and purified from mouse ovarian tissues. The long noncoding (lnc) RNA growth arrest-specific 5 sequence (GAS5) transcribed from mammalian genomes plays important regulatory roles in various developmental processes. However, there is no study on the relationship between GAS5 and FGSC development in vitro. In this study, we showed that GAS5 was highly expressed in the neonatal mouse ovary and was located in both FGSCs and oocytes...
February 8, 2018: Gene
https://www.readbyqxmd.com/read/29414789/a-long-noncoding-lnc-rna-governs-expression-of-the-phosphate-transporter-pho84-in-fission-yeast-and-has-cascading-effects-on-the-flanking-prt-lncrna-and-pho1-genes
#3
Angad Garg, Ana M Sanchez, Stewart Shuman, Beate Schwer
The expression of the phosphate transporter Pho84 in fission yeast Schizosaccharomyces pombe is repressed in phosphate-rich medium and induced during phosphate starvation. Two other phosphate-responsive genes in S. pombe (pho1 and tgp1) had been shown to be repressed in cis by transcription of a long noncoding (lnc) RNA from the upstream flanking gene, but whether pho84 expression is regulated in this manner is unclear. Here we show that repression of pho84 is enforced by transcription of the SPBC8E4.02c locus upstream of pho84 to produce a lncRNA that we name prt2 (pho-repressive transcript 2) We identify two essential elements of the prt2 promoter: HomolD box and TATA box, mutations of which inactivate the prt2 promoter and derepress the downstream pho84 promoter under phosphate-replete conditions...
February 2, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29398326/the-role-of-lnc-dc-long-non-coding-rna-and-socs1-in-the-regulation-of-stat3-in-coronary-artery-disease-and-type-2-diabetes-mellitus
#4
Asieh Alikhah, Majid Pahlevan Kakhki, Amirhossain Ahmadi, Reyhaneh Dehghanzad, Mohammad Ali Boroumand, Mehrdad Behmanesh
AIMS: Coronary artery disease (CAD) can be classified as an inflammatory disease, which affected by type 2 diabetes mellitus (T2DM). Elevated levels of many inflammatory molecules were found in the serum of patients with CAD. STAT3 molecule as a transcription factor plays an important role in the cytokines expression. Here, we examined the expression levels of STAT3 and its important regulatory genes lnc-DC and SOCS1, in patients with CAD and T2DM. METHODS: Blood samples were obtained from 37 CAD+ and 36 CAD- patients...
December 6, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29383128/genome-wide-identification-of-long-non-coding-rna-and-mrna-profiling-using-rna-sequencing-in-subjects-with-sensitive-skin
#5
Li Yang, Lechun Lyu, Wenjuan Wu, Dongyun Lei, Ying Tu, Dan Xu, Jiaqi Feng, Li He
Sensitive skin (SS) is a condition of subjective cutaneous hyper-reactivity. The role of long non-coding RNAs (lncRNAs) in subjects with SS is unclear. Therefore, the aim of the present study was to provide a comprehensive profile of the mRNAs and lncRNAs in subjects with SS. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis presented the characteristics of associated protein-coding genes. In addition, a co-expression network of lncRNA and mRNA was constructed to identify potential underlying regulation targets; the results were verified by quantitative real-time PCR (qRT-PCR) and RNA-seq analyses in patients with SS and normal samples...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29375682/long-non-coding-rna-mdc1-as-inhibits-human-gastric-cancer-cell-proliferation-and-metastasis-through-an-mdc1-dependent-mechanism
#6
Ying Qin, Shutong Zhuang, Jianfeng Wen, Kai Zheng
Gastric cancer is the third leading cause of cancer-associated mortality worldwide and is one of the most common malignancies in China. However, the molecular mechanisms underlying the tumorigenesis of gastric cancer remain largely unclear. Long non-coding (Lnc)RNAs have been demonstrated to serve significant roles in the tumorigenesis of various types of cancer. The present study aimed to explore the role of the LncRNA mediator of DNA damage checkpoint protein 1-antisense RNA (MDC1-AS), the antisense transcript of MDC1, in human gastric cancer...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29370759/identification-of-gossypium-hirsutum-long-non-coding-rnas-lncrnas-under-salt-stress
#7
Fenni Deng, Xiaopei Zhang, Wei Wang, Rui Yuan, Fafu Shen
BACKGROUND: Long non-coding RNAs (lncRNAs) represent a class of riboregulators that either directly act in long form or are processed into shorter microRNAs (miRNAs) and small interfering RNAs. Long noncoding RNAs (lncRNAs) are arbitrarily defined as RNA genes larger than 200 nt in length that have no apparent coding potential. lncRNAs have emerged as playing important roles in various biological regulatory processes and are expressed in a more tissue-specific manner than mRNA. Emerging evidence shows that lncRNAs participate in stress-responsive regulation...
January 25, 2018: BMC Plant Biology
https://www.readbyqxmd.com/read/29357711/lncrna-profiling-in-nci-h292-cells-after-stimulation-with-dermatophagoides-farinae-extracts
#8
Lilei Wang, Ying Zhou, Yubao Cui
Airway epithelium cells are the first line of defense against airborne allergens. When cultured, epithelial cells can be exposed to various allergens, providing an ideal model to investigate allergic disorders. This study sought to characterize the profile of long noncoding (lnc) RNAs, which can regulate gene expression and exert functions in diverse cellular processes, in airway epithelial cells exposed to house dust mite allergens. NCI-H292 cells were exposed to house dust mite extract for 24 h. RNA expression was profiled in exposed and unexposed cells...
January 2018: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/29346528/a-novel-stromal-lncrna-signature-reprograms-fibroblasts-to-promote-the-growth-of-oral-squamous-cell-carcinoma-via-lncrna-caf-interleukin-33
#9
Liang Ding, Jing Ren, Dongya Zhang, Yi Li, Xiaofeng Huang, Qingang Hu, Hui Wang, Yuxian Song, Yanhong Ni, Yayi Hou
Stromal carcinoma-related fibroblasts (CAFs) are the main type of non-immune cells in the tumor microenvironment (TME). CAFs interact with cancer cells to promote tumor proliferation. Long non-coding RNAs (lncRNAs) are known to regulate cell growth, apoptosis, and metastasis of cancer cells, but their role in stromal cells is unclear. Using RNA sequencing, we identified a stromal lncRNA signature during the transformation of CAFs from normal fibroblasts (NFs) in oral squamous cell carcinoma (OSCC). We uncovered an uncharacterized lncRNA, FLJ22447, which was remarkably up-regulated in CAFs, referred to LncRNA-CAF (Lnc-CAF) hereafter...
January 13, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29344178/long-non-coding-rna-lnctcf7-activates-the-wnt-%C3%AE-catenin-pathway-to-promote-metastasis-and-invasion-in-colorectal-cancer
#10
Tengyu Li, Jing Zhu, Xin Wang, Guowei Chen, Lie Sun, Shuai Zuo, Junling Zhang, Shanwen Chen, Ju Ma, Zihao Yao, Youwen Zheng, Zeyang Chen, Yucun Liu, Pengyuan Wang
Long non-coding RNA (Lnc)TCF7 is a novel lncRNA that is involved in tumorigenesis. Previous studies have revealed that lncTCF7 serves an essential role in maintaining cancer stem cell self-renewal; however, the functions of lncTCF7 in colorectal cancer (CRC) remain unknown. Therefore, the present study aimed to investigate the role of lncTCF7 in CRC. LncTCF7 was upregulated in 52/58 CRC tissues, and its expression correlated with tumor size, lymph metastasis and tumor-node-metastasis stage in CRC. Knocking down lncTCF7 in colon cancer cell lines decreased cell proliferation, migration and invasion, while lncTCF7 overexpression showed opposite changes...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29319165/long-noncoding-rna-neat1-regulate-papillary-thyroid-cancer-progression-by-modulating-mir-129-5p-klk7-expression
#11
Hong Zhang, Yuechang Cai, Li Zheng, Zhanlei Zhang, Xiaofeng Lin, Ningyi Jiang
PURPOSE: Considering the dilemma in papillary thyroid cancer treatment, this study intended to find solution in molecular respect. By probing into lncRNA-NEAT1/miR-129-5p/ KLK7 interaction, this study would provide new targets for future treatment. METHODS: Microarray analysis and R language package were applied to select possible lncRNA and miRNA. Luciferase reporter assay and RNA pull-down test were employed in the detection of target relationship between lncRNA and miRNA...
January 10, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29285059/long-noncoding-rna-hotair-promotes-the-proliferation-and-metastasis-of-osteosarcoma-cells-through-the-akt-mtor-signaling-pathway
#12
Enqi Li, Zhe Zhao, Baotong Ma, Jinli Zhang
It has been proven that long non-coding (lnc)RNAs serve an important role in the tumorigenesis and development of several types of human malignancy. Previous studies have demonstrated that the lncRNA Hox transcript antisense intergenic RNA (HOTAIR) is involved in the development various types of cancer, including osteosarcoma (OS). However, the underlying mechanisms by which it has an affect are still largely unknown. In the present study, it was observed that the expression of HOTAIR was significantly upregulated in OS tissues compared to matched adjacent normal tissues, using reverse transcription-quantitative polymerase chain reaction analysis...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29260523/-the-role-of-long-chain-non-coding-rna-paupar-in-the-process-of-bupivacaine-induced-neurotoxicity
#13
Li-Liang Zhang, Li-Na Qi, Ze-Yu Yao
OBJECTIVE: To observe the expression mode and modulation effects of lncRNA-Paupar in the process of bupivacaine induced neurotoxicity. METHODS: Dorsal root ganglion (DRG) neurons were cultured and neurotoxicity model was produced on it. And the expression of lncRNA-Paupar was evaluated by qRT-PCR. Lnc-Paupar specific siRNA-P and random control group siRNA-C were constructed,200 nmol/L siRNA-P,siRNA-C were transfected into ganglion cells and the apoptosis rate of transfected cells were observed by TUNEL method...
November 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29236315/lnc-rna-snhg20-participated-in-proliferation-invasion-and-migration-of-breast-cancer-cells-via-mir-495
#14
Yan-Xing Guan, Zhan-Min Zhang, Xue-Zhong Chen, Qing Zhang, Shao-Zheng Liu, Yong-Lu Zhang
OBJECTIVE: To explore the mechanism of lnc SNHG20 in the regulation of proliferation, invasion and migration of breast cancer cells. MATERIALS AND METHODS: mRNA levels of SNHG20, miR-495 and HER2 were detected by qRT-PCR. Protein level of HER2 was measured by Western blot. Cell proliferation, invasion and migration were detected by CCK-8 assay, Boyden chamber assay and Transwell assay. The combination between SNHG20 and miR-495 was confirmed by RNA pull down assay...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29228702/lncrna-and-mrna-profiling-during-activation-of-tilapia-macrophages-by-hsp70-and-streptococcus-agalactiae-antigen
#15
Honglin Luo, Huizan Yang, Yong Lin, Yongde Zhang, Chuanyan Pan, Pengfei Feng, Yanling Yu, Xiaohan Chen
Objectives: To investigate the lncRNA profiling during tilapia peritoneal macrophages (TPMs) activation and discuss the relationship between lncRNA and mRNA. Materials and Methods: RNA sequencing was used to investigate the lncRNA and mRNA profiles of TPMs activation following stimulation with Streptococcus agalactiae (Sa) antigen, heat shock protein 70 (HSP70) and HSP70+Sa. The expressions of lncRNA and mRNA were confirmed by qPCR. 356 lncRNA, 10173 mRNA and 1782 transcripts of uncertain coding potential (TUCP) were differentially expressed by pairwise comparison...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29216366/lncrna-lnc-ri-regulates-homologous-recombination-repair-of-dna-double-strand-breaks-by-stabilizing-rad51-mrna-as-a-competitive-endogenous-rna
#16
Liping Shen, Qi Wang, Ruixue Liu, Zhongmin Chen, Xueqing Zhang, Pingkun Zhou, Zhidong Wang
DNA double-strand break (DSB) repair is critical for the maintenance of genome stability. The current models of the mechanism of DSB repair are based on studies of DNA repair proteins. Long non-coding RNAs (lncRNAs) have recently emerged as new regulatory molecules, with diverse functions in biological processes. In the present study, we found that expression of the ionizing radiation-inducible lncRNA, lnc-RI, was correlate negatively with micronucleus frequencies in human peripheral blood lymphocytes. Knockdown of lnc-RI significantly increased spontaneous DSBs levels, which was confirmed to be associated with the decreased efficiency of homologous recombination (HR) repair of DSBs...
December 4, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29213066/crispr-cas9-mediated-mutation-of-mouse-il-1%C3%AE-nuclear-localisation-sequence-abolishes-expression
#17
Michael J D Daniels, Antony D Adamson, Neil Humphreys, David Brough
Inflammation is a host defense process against infection. Inflammatory mediators include cytokines of the interleukin-1 family, such as IL-1α and IL-1β. Unlike IL-1β, IL-1α carries an N-terminal nuclear localisation sequence (NLS) and is trafficked to the nucleus. The importance of IL-1α nuclear localisation is poorly understood. Here, we used CRISPR/Cas9 to make inactivating mutations to the NLS on the Il1a gene. A colony of NLS mutant mice was successfully generated with precise knock-in mutations to incapacitate NLS function...
December 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29207090/long-intergenic-non%C3%A2-coding-rna%C3%A2-p21-mediates-cardiac-senescence-via-the-wnt-%C3%AE-%C3%A2-catenin-signaling-pathway-in-doxorubicin-induced-cardiotoxicity
#18
Zhongdong Xie, Wenzheng Xia, Meng Hou
Doxorubicin (Dox)-induced cardiotoxicity has been a well‑known phenomenon to clinicians and scientists for decades. It has been confirmed that Dox‑dependent cardiotoxicity is accompanied by cardiac cellular senescence. However, the molecular mechanisms underlying Dox cardiotoxicity remains to be fully elucidated. Long non‑coding (lnc) RNAs regulate gene transcription and the fate of post‑transcriptional mRNA, which affects a broad range of age‑associated physiological and pathological conditions, including cardiovascular disease and cellular senescence...
November 28, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29196750/a-novel-y-specific-long-non-coding-rna-associated-with-cellular-lipid-accumulation-in-hepg2-cells-and-atherosclerosis-related-genes
#19
Elsa Molina, Guat S Chew, Stephen A Myers, Elyse M Clarence, James M Eales, Maciej Tomaszewski, Fadi J Charchar
There is an increasing appreciation for the role of the human Y chromosome in phenotypic differences between the sexes in health and disease. Previous studies have shown that genetic variation within the Y chromosome is associated with cholesterol levels, which is an established risk factor for atherosclerosis, the underlying cause of coronary artery disease (CAD), a major cause of morbidity and mortality worldwide. However, the exact mechanism and potential genes implicated are still unidentified. To date, Y chromosome-linked long non-coding RNAs (lncRNAs) are poorly characterized and the potential link between these new regulatory RNA molecules and hepatic function in men has not been investigated...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29190961/long-noncoding-rna-ccat1-functions-as-a-cerna-to-antagonize-the-effect-of-mir-410-on-the-down-regulation-of-itpkb-in-human-hct-116-and-hct-8-cells
#20
Bo Li, Chong Shi, Jingming Zhao, Bai Li
Colorectal cancer is one of the most common malignancies, which has seriously affected people's health. Abnormal expression of long non-coding RNAs and microRNAs are closely related to the process of occurrence, development, invasion and metastasis of colorectal cancer. However, the effect of lnc CCAT1 on human HCT-116/HCT-8 cells and its potential mechanism were investigated. In present study, differential expression of CCAT1, miR-410 and ITPKB were detected in colon cancer tissues and adjacent parts. Then the prediction programs were applied to predict the target genes of miR-410...
November 3, 2017: Oncotarget
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