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Osteoarthritis biomarkers

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https://www.readbyqxmd.com/read/28543921/correlations-of-low-field-nmr-and-variable-field-nmr-parameters-with-osteoarthritis-in-human-articular-cartilage-under-load
#1
Erik Rössler, Carlos Mattea, Simo Saarakkala, Petri Lehenkari, Mikko Finnilä, Lassi Rieppo, Sakari Karhula, Miika T Nieminen, Siegfried Stapf
NMR experiments carried out at magnetic fields below 1 T provide new relaxation parameters unavailable with conventional clinical scanners. Contrast of T1 generally becomes larger towards low fields, as slow molecular reorientation processes dominate relaxation at the corresponding Larmor frequencies. This advantage has to be considered in the context of lower sensitivity and frequently reduced spatial resolution. The layered structure of cartilage is one example where a particularly strong variation of T1 across the tissue occurs, being affected by degenerative diseases such as osteoarthritis (OA)...
May 24, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28535729/quantitative-genetics-of-circulating-hyaluronic-acid-ha-and-its-correlation-with-hand-osteoarthritis-and-obesity-related-phenotypes-in-a-community-based-sample
#2
Jai Prakash, Gulzhan Gabdulina, Svetlana Trofimov, Gregory Livshits
BACKGROUND: One of the potential molecular biomarkers of osteoarthritis (OA) is hyaluronic acid (HA). HA levels may be related to the severity and progression of OA. However, little is known about the contribution of major risk factors for osteoarthritis, e.g., obesity-related phenotypes and genetics to HA variation. AIM: To clarify the quantitative effect of these factors on HA. METHODS: An ethnically homogeneous sample of 911 apparently healthy European-derived individuals, assessed for radiographic hand osteoarthritis (RHOA), HA, leptin, adiponectin, and several anthropometrical measures of obesity-related phenotypes...
May 24, 2017: Annals of Human Biology
https://www.readbyqxmd.com/read/28529106/engineered-cartilage-regeneration-from-adipose-tissue-derived-mesenchymal-stem-cells-a-morphomolecular-study-on-osteoblast-chondrocyte-and-apoptosis-evaluation
#3
Marta Anna Szychlinska, Paola Castrogiovanni, Houda Nsir, Michelino Di Rosa, Claudia Guglielmino, Rosalba Parenti, Giovanna Calabrese, Elisabetta Pricoco, Lucia Salvatorelli, Gaetano Magro, Rosa Imbesi, Ali Mobasheri, Giuseppe Musumeci
The poor self-repair capacity of cartilage tissue in degenerative conditions, such as osteoarthritis (OA), has prompted the development of a variety of therapeutic approaches, such as cellular therapies and tissue engineering based on the use of mesenchymal stem cells (MSCs). The aim of this study is to demonstrate, for the first time, that the chondrocytes differentiated from rat adipose tissue derived-MSCs (AMSCs), are able to constitute a morphologically and biochemically healthy hyaline cartilage after 6 weeks of culture on a Collagen Cell Carrier (CCC) scaffold...
May 18, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28525322/a-systemic-review-of-existing-serological-possibilities-to-diagnose-canine-osteoarthritis-with-a-particular-focus-on-extracellular-matrix-proteoglycans-and-protein
#4
M Shahid, G Manchi, P Slunsky, O Naseer, A Fatima, B Leo, J Raila
Extra-cellular matrix (ECM) components are important and their stabilization is significant in maintaining normal healthy joint environment. In osteoarthritis (OA), ECM components are altered and indicate disease progression. The joint ECM is composed of proteoglycans (aggrecan, perlecan, inter α-trypsin inhibitor), glycoproteins (fibronectin, lubricin, COMP) and collagen types (most abundantly collagen type II) which represent structural and functional transformation during disease advancement. ECM investigation revealed significant biomarkers of OA that could be used as a diagnostic and therapeutic tool in different canine orthopedic diseases...
March 28, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28515465/gender-specific-differential-expression-of-exosomal-mirna-in-synovial-fluid-of-patients-with-osteoarthritis
#5
Ravindra Kolhe, Monte Hunter, Siyang Liu, Ravirajsinh N Jadeja, Chetan Pundkar, Ashis K Mondal, Bharati Mendhe, Michelle Drewry, Mumtaz V Rojiani, Yutao Liu, Carlos M Isales, Robert E Guldberg, Mark W Hamrick, Sadanand Fulzele
The pathogenesis of osteoarthritis (OA) is poorly understood, and therapeutic approaches are limited to preventing progression of the disease. Recent studies have shown that exosomes play a vital role in cell-to-cell communication, and pathogenesis of many age-related diseases. Molecular profiling of synovial fluid derived exosomal miRNAs may increase our understanding of OA progression and may lead to the discovery of novel biomarkers and therapeutic targets. In this article we report the first characterization of exosomes miRNAs from human synovial fluid...
May 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28511690/development-of-a-clinical-prediction-algorithm-for-knee-osteoarthritis-structural-progression-in-a-cohort-study-value-of-adding-measurement-of-subchondral-bone-density
#6
Michael P LaValley, Grace H Lo, Lori Lyn Price, Jeffrey B Driban, Charles B Eaton, Timothy E McAlindon
BACKGROUND: Risk prediction algorithms increase understanding of which patients are at greatest risk of a harmful outcome. Our goal was to create a clinically useful prediction algorithm for structural progression of knee osteoarthritis (OA), using medial joint space loss as a proxy; and to quantify the benefit of including periarticular bone mineral density (BMD) in the algorithm. METHODS: Participants were from the Osteoarthritis Initiative (OAI) Progression Cohort, with X-ray readings of medial joint space at 36- and 48-month visits, and a 30- or 36-month medial-to-lateral tibial BMD ratio (M:L BMD ratio) value...
May 16, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28507472/schisandrae-fructus-ethanol-extract-ameliorates-inflammatory-responses-and-articular-cartilage-damage-in-monosodium-iodoacetate-induced-osteoarthritis-in-rats
#7
Jin-Woo Jeong, Jongsik Kim, Eun Ok Choi, Da Hye Kwon, Gyu Min Kong, Il-Whan Choi, Bum Hoi Kim, Gi-Young Kim, Ki Won Lee, Ki Young Kim, Sung Goo Kim, Young Whan Choi, Su Hyun Hong, Cheol Park, Yung Hyun Choi
Schisandrae Fructus, the fruit of Schisandra chinensis (Turcz.) Baill., is widely used in traditional medicine for the treatment of a number of chronic diseases. Although, Schisandrae Fructus was recently reported to attenuate the interleukin (IL)-1β-induced inflammatory response in chondrocytes in vitro, its protective and therapeutic potential against osteoarthritis (OA) in an animal model remains unclear. Therefore, we investigated the effects of the ethanol extract of Schisandrae Fructus (SF) on inflammatory responses and cartilage degradation in a monosodium iodoacetate (MIA)-induced OA rat model...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28503667/neopeptide-analyser-a-software-tool-for-neopeptide-discovery-in-proteomics-data
#8
Mandy Peffers, Andrew R Jones, Antony McCabe, James Anderson
Experiments involving mass spectrometry (MS)-based proteomics are widely used for analyses of connective tissues. Common examples include the use of relative quantification to identify differentially expressed peptides and proteins in cartilage and tendon. We are working on characterising so-called 'neopeptides', i.e. peptides formed due to native cleavage of proteins, for example under pathological conditions. Unlike peptides typically quantified in MS workflows due to the in vitro use of an enzyme such as trypsin, a neopeptide has at least one terminus that was not due to the use of trypsin in the workflow...
April 7, 2017: Wellcome Open Research
https://www.readbyqxmd.com/read/28488017/c-reactive-protein-course-during-the-first-5-days-after-total-knee-arthroplasty-cannot-predict-early-prosthetic-joint-infection
#9
Christoph Windisch, Steffen Brodt, Eric Roehner, Georg Matziolis
INTRODUCTION: Periprosthetic joint infection (PJI) is one of the most devastating major complications after total knee arthroplasty (TKA). The laboratory value C-reactive protein (CRP) is the inflammatory biomarker most suitable for detecting a potential postoperative (p.o.) early infection in orthopaedic surgery. However, on the basis of multiple receiver operating characteristic (ROC) analyses, CRP only has limited sensitivity and specificity. The objective of the present study was to test the hypothesis that, besides the absolute preoperative CRP value, also the absolute postoperative CRP value and its course over the first 5 days after TKA are valid indicators of periprosthetic early infection...
May 9, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28473207/quantification-of-cartilage-oligomeric-matrix-protein-comp-and-a-comp-neoepitope-in-synovial-fluid-of-patients-with-different-joint-disorders-by-novel-automated-assays
#10
P Lorenzo, A Aspberg, T Saxne, P Önnerfjord
OBJECTIVE: To develop automated immunoassays for the quantification of Cartilage Oligomeric Matrix Protein (COMP) and a COMP neoepitope in synovial fluid and to investigate their diagnostic potential in different joint conditions. METHODS: Two sandwich immunoassays were developed for the quantification of COMP and a COMP neoepitope, using an automated analyser (IDS-iSYS, Immunodiagnostic Systems, Boldon, UK). Assay performance was evaluated in terms of sensitivity, recovery, linearity, and intra- and inter-assay precision...
May 2, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28471543/mri-and-biomechanics-multidimensional-data-analysis-reveals-r2-r1%C3%AF-as-an-early-predictor-of-cartilage-lesion-progression-in-knee-osteoarthritis
#11
Valentina Pedoia, Jenny Haefeli, Kazuhito Morioka, Hsiang-Ling Teng, Lorenzo Nardo, Richard B Souza, Adam R Ferguson, Sharmila Majumdar
PURPOSE: To couple quantitative compositional MRI, gait analysis, and machine learning multidimensional data analysis to study osteoarthritis (OA). OA is a multifactorial disorder accompanied by biochemical and morphological changes in the articular cartilage, modulated by skeletal biomechanics and gait. While we can now acquire detailed information about the knee joint structure and function, we are not yet able to leverage the multifactorial factors for diagnosis and disease management of knee OA...
May 4, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28463061/exercise-protects-against-insulin-dependent-diabetes-induced-osteoarthritis-in-rats-a-scanning-electron-microscopy-study
#12
Fahaid Al-Hashem, Abbas O El Karib, Ismaeel Bin-Jaliah, Mohammad Dallak, Hussein F Sakr, Refaat A Eid, Mohamed Samir A Zaki, Mariam Al-Shamsi, Mohamed A Haidara, Bahjat Al-Ani
We tested the hypothesis that swim exercise can protect the articular cartilage from damages induced secondary to insulin-dependent diabetes mellitus in rats using the scanning electron microscopy and to monitor the blood levels of oxidative and antioxidative stress biomarkers that are known to be modulated in osteoarthritis (OA). A profound damage to the cartilage was observed in the diabetic rats. Our findings also show that swim exercise protects the knee joints from damage induced by diabetes as well as significantly inhibiting OA-induced upregulation of thiobarbituric acid reactive substances (TBARS) and tumor necrosis factor alpha (TNF-α) and augmented superoxide dismutase (SOD) inhibition by OA...
May 2, 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28460627/synovial-fluid-and-serum-concentrations-of-inflammatory-markers-in-rheumatoid-arthritis-psoriatic-arthritis-and-osteoarthitis-a-systematic-review
#13
Emma Altobelli, Paolo Matteo Angeletti, Domenico Piccolo, Rossella De Angelis
The aim of this review is to investigate systematically the presence of the most extensively studied synovial fluid (SF) and/or serum markers in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and osteoarthritis (OA) their associations and correlations with laboratory and clinical data, with a view to providing insights for future research. Papers were selected using the PRISMA flow-chart. Search of the electronic databases according to the above criteria found a total of 55 papers. Examination led to the exclusion of 39 papers...
April 27, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28456927/associations-of-three-dimensional-t1-rho-mr-mapping-and-three-dimensional-t2-mapping-with-macroscopic-and-histologic-grading-as-a-biomarker-for-early-articular-degeneration-of-knee-cartilage
#14
T Sasho, J Katsuragi, S Yamaguchi, H Haneishi, T Aizimu, T Tanaka, A Watanabe, Y Sato, R Akagi, K Matsumoto, T Uno, K Motoori
T1 rho and T2 mapping are magnetic resonance imaging (MRI) techniques to detect early degenerative changes in cartilage. Recent advancements have enabled 3D acquisition for both techniques. The objective of the present study was to examine the correlation of 3D T1 rho and 3D T2 mapping with macroscopic and histological characteristics of knee cartilage. Twenty-one patients who underwent total knee arthroplasty due to osteoarthritis with involvement of the medial compartment but with minimum involvement of the lateral compartment were enrolled...
April 29, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28456879/anti-inflammatory-effect-as-a-mechanism-of-effectiveness-underlying-the-clinical-benefits-of-pelotherapy-in-osteoarthritis-patients-regulation-of-the-altered-inflammatory-and-stress-feedback-response
#15
E Ortega, I Gálvez, M D Hinchado, J Guerrero, L Martín-Cordero, S Torres-Piles
The purpose of the present investigation was to evaluate whether an anti-inflammatory effect together with an improvement of the regulation of the interaction between the inflammatory and stress responses underlies the clinical benefits of pelotherapy in osteoarthritis (OA) patients. This study evaluated the effects of a 10-day cycle of pelotherapy at the spa centre 'El Raposo' (Spain) in a group of 21 OA patients diagnosed with primary knee OA. Clinical assessments included pain intensity using a visual analog scale; pain, stiffness and physical function using the Western Ontario and McMaster Universities Arthritis Index; and health-related quality of life using the EuroQol-5D questionnaire...
April 29, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28448087/effect-of-a-mediterranean-type-diet-on-inflammatory-and-cartilage-degradation-biomarkers-in-patients-with-osteoarthritis
#16
J Dyer, G Davison, S M Marcora, A R Mauger
OBJECTIVES: To investigate the effects of a Mediterranean type diet on patients with osteoarthritis (OA). PARTICIPANTS: Ninety-nine volunteers with OA (aged 31 - 90 years) completed the study (83% female). SETTING: Southeast of England, UK. DESIGN: Participants were randomly allocated to the dietary intervention (DIET, n = 50) or control (CON, n = 49). The DIET group were asked to follow a Mediterranean type diet for 16 weeks whereas the CON group were asked to follow their normal diet...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28433814/synovial-fluid-pro-inflammatory-profile-differs-according-to-the-characteristics-of-knee-pain
#17
Y Y Leung, J L Huebner, B Haaland, S B Siew Wong, V B Kraus
OBJECTIVE: The role of inflammation and pain in osteoarthritis (OA) is not fully understood. We evaluated the association between pro-inflammatory biomarkers and pain. METHODS: We used baseline data and samples from a randomized controlled trial of colchicine for symptomatic knee OA. Severity of pain of the more symptomatic knee was assessed by National Health and Nutrition Examination Survey-I (NHANES-I) criterion and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain index...
April 19, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28413518/effect-of-n-acetylglucosamine-administration-on-cartilage-metabolism-and-safety-in-healthy-subjects-without-symptoms-of-arthritis-a-case-report
#18
Daiki Kubomura, Tomoya Ueno, Masanori Yamada, Akihito Tomonaga, Isao Nagaoka
N-acetylglucosamine (GlcNAc) is a widely accepted treatment for osteoarthritis (OA); however, its effect on healthy individuals is poorly understood. To evaluate the effect of GlcNAc administration on healthy subjects that do not exhibit symptoms of arthritis, the present randomized, double-blind, placebo-controlled study was performed. In the present study, 68 male and female Japanese participants, without symptomatic and radiographic evidence of OA, were enrolled and randomly allocated to receive placebo or GlcNAc (500 or 1,000 mg/day) for 16 weeks...
April 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28413025/biochemical-and-biological-attributes-of-matrix-metalloproteinases
#19
Ning Cui, Min Hu, Raouf A Khalil
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that are involved in the degradation of various proteins in the extracellular matrix (ECM). Typically, MMPs have a propeptide sequence, a catalytic metalloproteinase domain with catalytic zinc, a hinge region or linker peptide, and a hemopexin domain. MMPs are commonly classified on the basis of their substrates and the organization of their structural domains into collagenases, gelatinases, stromelysins, matrilysins, membrane-type (MT)-MMPs, and other MMPs...
2017: Progress in Molecular Biology and Translational Science
https://www.readbyqxmd.com/read/28411808/validation-of-a-new-method-by-nano-liquid-chromatography-on-chip-tandem-mass-spectrometry-for-combined-quantitation-of-c3f-and-the-v65-vitronectin-fragment-as-biomarkers-of-diagnosis-and-severity-of-osteoarthritis
#20
Gaël Cobraiville, Marianne Fillet, Mohammed Sharif, Khadija Ourradi, Gwenaël Nys, Michel G Malaise, Dominique de Seny
Microfluidic liquid chromatography coupled to a nanoelectrospray source ion trap mass spectrometry was used for the absolute and simultaneous quantitation of C3f and the V65 vitronectin fragment in serum. The method was first carefully optimized and then validated in serum biological matrix. Stable isotopes for the two biomarkers of interest were used as stable isotope labeled peptide standards. A weighted 1/x(2) quadratic regression for C3f and a weighted 1/x quadratic regression for the V65 vitronectin peptide were selected for calibration curves...
July 1, 2017: Talanta
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