keyword
MENU ▼
Read by QxMD icon Read
search

Osteoarthritis biomarkers

keyword
https://www.readbyqxmd.com/read/29783048/effect-of-auriculotherapy-on-the-plasma-concentration-of-biomarkers-in-individuals-with-knee-osteoarthritis
#1
Rebeca Graça Costa-Cavalcanti, Danúbia da Cunha de Sá-Caputo, Eloá Moreira-Marconi, Cristiane Ribeiro Kütter, Samuel Brandão-Sobrinho-Neto, Laisa Liane Paineiras-Domingos, Marcia Cristina Moura-Fernandes, João Marcelo Castelpoggi da Costa, José Maurício de Morais Carmo, José Firmino Nogueira-Neto, Shyang Chang, Mario Bernardo-Filho
Knee osteoarthritis (KOA) is one of the most frequent non-communicable diseases with pain associated symptoms and affects the musculoskeletal system. Various forms of treatment can be indicated and non-pharmacological treatment is also an available option for the management of KOA individuals. For instance, auriculotherapy (AT) is one possible procedure associated with the Traditional Chinese Medicine for dealing with KOA. It is believed that the concentration of certain biomarkers could be altered in individuals with KOA after AT...
May 18, 2018: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/29782915/new-insights-into-the-natural-course-of-knee-osteoarthritis-early-regulation-of-cytokines-and-growth-factors-with-emphasis-on-sex-dependent-angiogenesis-and-tissue-remodeling-a-pilot-study
#2
Kalle Kisand, Ann Tamm, Mare Lintrop, Agu Tamm
OBJECTIVE: This study was conducted to identify cytokine profiles associated with radiographic phenotypes of knee osteoarthritis (rKOA) with a focus on early stage of the disease. METHODS: The pilot population study involved 60 middle-aged patients (mean age 50±7.3y.). Standardized weight-bearing anteroposterior and axial radiographs were used to assess rKOA severity in tibiofemoral (TFJ) of patellofemoral joint (PFJ) by grading system (grades 0-3). Luminex (xMAP® ) technology was used to simultaneously assess 60 biomarkers...
May 18, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29771395/glucosamine-and-chondroitin-sulfate-what-has-been-learned-since-the-glucosamine-chondroitin-arthritis-intervention-trial
#3
Nicholas DiNubile
Glucosamine and chondroitin sulfate, alone or in combination, are used worldwide by individuals suffering from osteoarthritis pain. They are by prescription in some countries but are available as over-the-counter dietary supplements in other countries, such as the United States. The inconclusive results of the National Institutes of Health-sponsored Glucosamine/chondroitin Arthritis Intervention Trial (GAIT) did little to clarify the efficacy of these agents. However, some newer studies have provided a better perspective on the potential benefits that they can offer...
May 16, 2018: Orthopedics
https://www.readbyqxmd.com/read/29769754/detection-of-bone-loss-via-subchondral-bone-analysis
#4
Jean-Baptiste Vimort, Antonio Ruellas, Jack Prothero, J S Marron, Matthew McCormick, Lucia Cevidanes, Erika Benavides, Beatriz Paniagua
To date, there is no single sign, symptom, or test that can clearly diagnose early stages of Temporomandibular Joint Osteoarthritis (TMJ OA). However, it has been observed that changes in the bone occur in early stages of this disease, involving structural changes both in the texture and morphometry of the bone marrow and the subchondral cortical plate. In this paper we present a tool to detect and highlight subtle variations in subchondral bone structure obtained from high resolution Cone Beam Computed Tomography (hr-CBCT) in order to help with detecting early TMJ OA...
February 2018: Proceedings of SPIE
https://www.readbyqxmd.com/read/29744983/expression-of-p16-ink-4a-is-a-biomarker-of-chondrocyte-aging-but-does-not-cause-osteoarthritis
#5
Brian O Diekman, Garrett A Sessions, John A Collins, Anne K Knecht, Susan L Strum, Natalia K Mitin, Cathy S Carlson, Richard F Loeser, Norman E Sharpless
Cellular senescence drives a functional decline of numerous tissues with aging by limiting regenerative proliferation and/or by producing pro-inflammatory molecules known as the senescence-associated secretory phenotype (SASP). The senescence biomarker p16INK 4a is a potent inhibitor of the cell cycle but is not essential for SASP production. Thus, it is unclear whether p16INK 4a identifies senescence in hyporeplicative cells such as articular chondrocytes and whether p16INK 4a contributes to pathologic characteristics of cartilage aging...
May 9, 2018: Aging Cell
https://www.readbyqxmd.com/read/29743078/nonclinical-and-clinical-pharmacological-characterization-of-the-potent-and-selective-cathepsin-k-inhibitor-miv-711
#6
Erik Lindström, Biljana Rizoska, Ian Henderson, Ylva Terelius, Markus Jerling, Charlotte Edenius, Urszula Grabowska
BACKGROUND: Cathepsin K is an attractive therapeutic target for diseases in which bone resorption is excessive such as osteoporosis and osteoarthritis (OA). The current paper characterized the pharmacological profile of the potent and selective cathepsin K inhibitor, MIV-711, in vitro and in cynomolgus monkeys, and assessed translation to human based on a single dose clinical study in man. METHODS: The potency and selectivity of MIV-711 were assessed in vitro using recombinant enzyme assays and differentiated human osteoclasts...
May 9, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29739086/mir-300-serves-as-potential-biomarker-to-screen-knee-osteoarthritis-patients-by-targeting-tnf%C3%AE
#7
Zihao Zhou, Fengde Tian, Ning An, Yao Zhang, Changcheng Wang, Lin Guo
BACKGROUND: This study mainly explored the serum level of miR-300 with the risk of knee OA, thereby evaluating their diagnostic ability for treatment of knee osteoarthritis (KOA) patients. METHODS: In the current study, we evaluated the level of TNFα in KOA patients and HCs. The serum was used to quantify the level of TNF-α by way of a sandwich enzyme-linked immunosorbent assay. Dual luciferase reporter assay was carried out to identify the possible target gene of miR-300...
April 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29734501/using-multidimensional-topological-data-analysis-to-identify-traits-of-hip-osteoarthritis
#8
Jasmine Rossi-deVries, Valentina Pedoia, Michael A Samaan, Adam R Ferguson, Richard B Souza, Sharmila Majumdar
BACKGROUND: Osteoarthritis (OA) is a multifaceted disease with many variables affecting diagnosis and progression. Topological data analysis (TDA) is a state-of-the-art big data analytics tool that can combine all variables into multidimensional space. TDA is used to simultaneously analyze imaging and gait analysis techniques. PURPOSE: To identify biochemical and biomechanical biomarkers able to classify different disease progression phenotypes in subjects with and without radiographic signs of hip OA...
May 7, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29729412/sustained-intra-articular-release-of-celecoxib-in-an-equine-repeated-lps-synovitis-model
#9
Stefan M Cokelaere, Saskia G M Plomp, Esther de Boef, Mike de Leeuw, Sophie Bool, Chris H A van de Lest, P René van Weeren, Nicoline M Korthagen
Synovial inflammation is an important characteristic of arthritic disorders like osteoarthritis and rheumatoid arthritis. Orally administered non-steroidal anti-inflammatory drugs (NSAIDs) such as celecoxib are among the most widely prescribed drugs to manage these debilitating diseases. Intra-articular delivery in biodegradable in situ forming hydrogels overcomes adverse systemic effects and prolongs drug retention in the joint. In this study two formulations of celecoxib (40 mg/g and 120 mg/g) in a propyl-capped PCLA-PEG-PCLA triblock copolymer were sequentially evaluated in a multiple LPS challenge equine synovitis model...
May 2, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29723633/associations-between-the-chemokine-biomarker-ccl2-and-knee-osteoarthritis-outcomes-the-johnston-county-osteoarthritis-project
#10
Lara Longobardi, Joanne M Jordan, Xiaoyan A Shi, Jordan B Renner, Todd A Schwartz, Amanda E Nelson, David A Barrow, Virginia B Kraus, Anna Spagnoli
OBJECTIVE: Our study analyzes the association between chemokine-ligand-2 (CCL2) serum concentrations at baseline and knee radiographic OA (knee-rOA), knee-rOA progression, individual radiographic features and knee symptomatic OA at 5-year follow-up. DESIGN: OA outcomes were analyzed in a community-based cohort including a baseline enrollment and a 5-year follow-up. Baseline CCL2 serum concentrations were assessed by multiplex assay and associated with presence or progression of individual radiographic features at 5-year follow-up...
April 30, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29721684/association-of-subchondral-bone-texture-on-magnetic-resonance-imaging-with-radiographic-knee-osteoarthritis-progression-data-from-the-osteoarthritis-initiative-bone-ancillary-study
#11
James W MacKay, Geeta Kapoor, Jeffrey B Driban, Grace H Lo, Timothy E McAlindon, Andoni P Toms, Andrew W McCaskie, Fiona J Gilbert
OBJECTIVES: To assess whether initial or 12-18-month change in magnetic resonance imaging (MRI) subchondral bone texture is predictive of radiographic knee osteoarthritis (OA) progression over 36 months. METHODS: This was a nested case-control study including 122 knees/122 participants in the Osteoarthritis Initiative (OAI) Bone Ancillary Study, who underwent MRI optimised for subchondral bone assessment at either the 30- or 36-month and 48-month OAI visits. Case knees (n = 61) had radiographic OA progression between the 36- and 72-month OAI visits, defined as ≥ 0...
May 2, 2018: European Radiology
https://www.readbyqxmd.com/read/29717787/isotropic-morphometry-and-multicomponent-t-1-%C3%AF-mapping-of-human-knee-articular-cartilage-in-vivo-at-3t
#12
Rahman Baboli, Azadeh Sharafi, Gregory Chang, Ravinder R Regatte
BACKGROUND: The progressive loss of hyaline articular cartilage due to osteoarthritis (OA) changes the functional and biochemical properties of cartilage. Measuring the T1 ρ along with the morphological assessment can potentially be used as noninvasive biomarkers in detecting early-stage OA. To correlate the biochemical and morphological data, submillimeter isotropic resolution for both studies is required. PURPOSE: To implement a high spatial resolution 3D-isotropic-MRI sequence for simultaneous assessment of morphological and biexponential T1 ρ relaxometry of human knee cartilage in vivo...
May 2, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29709696/imsyc-immunologic-synovitis-score-a-new-score-for-synovial-membrane-characterization-in-inflammatory-and-non-inflammatory-arthritis
#13
Aurélie Najm, Benoît le Goff, Guillaume Venet, Thomas Garraud, Jérôme Amiaud, Noura Biha, Céline Charrier, Sophie Touchais, Vincent Crenn, Frédéric Blanchard, Veit Krenn
OBJECTIVES: Krenn synovitis Score has been developed by Krenn et al. in order to assess synovitis severity and is used in synovial research. Cell signature of synovial tissue can be studied using immunohistochemistry and is of interest as a biomarker for both prognosis and prediction of response to treatment. However, no synovitis score including immunohistochemistry exists yet. In order to answer this unmet need, we propose a new Immunologic SYnovitis sCore (IMSYC) adding 5 components to the Krenn score: CD68, CD3, CD20, CD31 and Ki67 immunostaining...
April 27, 2018: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/29704569/protein-biomarkers-associated-with-pain-mechanisms-in-osteoarthritis
#14
Christian S Thudium, Henrik Löfvall, Morten A Karsdal, Anne-Christine Bay-Jensen, Asger Reinstrup Bihlet
Osteoarthritis (OA) is the most common arthritic disease in the world, leading to debilitating pain and destruction of joint tissues. While pain is the hallmark symptom of osteoarthritis, clear associations between pain and disease processes involved in joint deterioration are lacking. OA pain is multifactorial and may arise from multiple distinct or concurrent mechanisms, and may thus present as different pain sub-types. Several biomarkers developed to reflect important pathological processes are available, and associations between such biomarkers and OA pain may give hints to important pathological features, which have not been possible to assess using clinical, radiographic or magnetic resonance imaging techniques...
April 25, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29704559/quantitative-measurement-of-cartilage-volume-is-possible-using-two-dimensional-magnetic-resonance-imaging-data-sets
#15
L F Schaefer, V Nikac, J A Lynch, J Duryea
PURPOSE: 3D Magnetic resonance imaging (MRI) scans are generally used for quantitative cartilage measurements in knee osteoarthritis. However, a great deal of MRI data is from 2D scans, often thought to be unsuitable for quantitative cartilage assessment. The goal of our study was to demonstrate that mLACS, a modified version of the Local Area Cartilage Segmentation (LACS) method, could be used to measure cartilage volume on 2D MRI images. METHODS: We studied 301 randomly selected subjects from the OA Biomarkers Consortium FNIH Study, a nested case-control study within the Osteoarthritis Initiative (OAI)...
April 25, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29702061/aggrecanase-degradation-of-type-iii-collagen-is-associated-with-clinical-knee-pain
#16
A C Bay-Jensen, C F Kjelgaard-Petersen, K K Petersen, L Arendt-Nielsen, H L Quasnichka, A Mobasheri, M A Karsdal, D J Leeming
There is a lack of biochemical markers for non-invasive and objective assessment of symptomatic osteoarthritis (OA). Aggrecanase activity has been shown to be associated with joint deterioration and symptomatic disease through the degradation of extracellular matrix proteins, such as type III collagen. Our study aimed to identify and develop a novel biomarker by measuring an aggrecanase-mediated type III collagen neoepitope, and correlate levels of this biomarker with OA joint pain. Mass spectrometric analysis of purified type III collagen, degraded by the aggrecanase A Disintigrin and Metalloproteinase with Thrombospondin motif (ADAMTS), revealed a fragment generated by ADAMTS-1, -4 and -8...
April 24, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29683034/inflammatory-biomarker-profiling-in-total-joint-arthroplasty-and-its-relevance-to-circulating-levels-of-lubricin-a-novel-proteoglycan
#17
Kevin Galicia, Chase Thorson, Andrew Banos, Matthew Rondina, William Hopkinson, Debra Hoppensteadt, Jawed Fareed
Lubricin, also known as proteoglycan 4, acts as an antiadhesive and boundary lubricant to prevent cartilage damage in healthy joints. Following injury, a decrease in synovial fluid (SF) lubricin may lead to secondary osteoarthritis (OA). Inflammatory biomarkers, such as IL-1β and TNF-α, are also implicated in the pathophysiology of OA. Interestingly, they have been shown to suppress the expression and secretion of lubricin in SF. This study aims to compare circulating levels of inflammatory biomarkers and lubricin between total joint arthroplasty (TJA) patients and healthy individuals...
January 1, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29673544/no-effect-of-creatine-monohydrate-supplementation-on-inflammatory-and-cartilage-degradation-biomarkers-in-individuals-with-knee-osteoarthritis
#18
Stephen M Cornish, Jason D Peeler
The study purpose was to evaluate the effectiveness of creatine monohydrate supplementation (20 grams/day for 1 week and then 5 grams/day for 11 weeks) on inflammation (C-reactive protein, interleukin-1β, interleukin-6, s100 A8/A9, and tumor necrosis factor-α) and cartilage degradation (serum cartilage oligomeric matrix protein) in patients with knee osteoarthritis. We hypothesized that supplementing with creatine monohydrate for 12 weeks would lower biomarkers of inflammation and cartilage degradation in patients with knee osteoarthritis when compared to placebo...
March 2018: Nutrition Research
https://www.readbyqxmd.com/read/29672812/cartilage-imaging-techniques-and-developments
#19
Edwin H G Oei, Marius C Wick, Anja Müller-Lutz, Christoph Schleich, Falk R Miese
Cartilage degeneration is one of the most common chronic age-related joint disorders leading to pain and reduced joint motion. The increasing prevalence of osteoarthritis requires accurate cartilage imaging, both clinically and in research. Detailed cartilage imaging is also necessary for traumatic cartilage lesions and for pre- and postoperative assessment of cartilage repair procedures. Although still widely used, conventional radiography bears significant limitations because it assesses cartilage indirectly by joint space width...
April 2018: Seminars in Musculoskeletal Radiology
https://www.readbyqxmd.com/read/29670212/mitochondrial-dna-variation-and-the-pathogenesis-of-osteoarthritis-phenotypes
#20
REVIEW
Francisco J Blanco, Ana M Valdes, Ignacio Rego-Pérez
Mitochondria and mitochondrial DNA (mtDNA) variation are now recognized as important factors in the development of osteoarthritis (OA). Mitochondria are the energy powerhouses of the cell, and also regulate different processes involved in the pathogenesis of OA including inflammation, apoptosis, calcium metabolism and the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS). Mitochondria contain their own genetic material, mtDNA, which evolved through the sequential accumulation of mtDNA variants to enable humans to adapt to different climates...
April 18, 2018: Nature Reviews. Rheumatology
keyword
keyword
19188
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"