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Osteoarthritis biomarkers

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https://www.readbyqxmd.com/read/28217895/serum-urate-levels-predict-joint-space-narrowing-in-non-gout-patients-with-medial-knee-osteoarthritis
#1
Svetlana Krasnokutsky, Charles Oshinsky, Mukundan Attur, Sisi Ma, Hua Zhou, Fangfei Zheng, Meng Chen, Jyoti Patel, Jonathan Samuels, Virginia C Pike, Ravinder Regatte, Jenny Bencardino, Leon Rybak, Steven Abramson, Michael H Pillinger
OBJECTIVE: OA pathogenesis includes both mechanical and inflammatory features. Studies have implicated synovial fluid urate (UA) as a potential OA biomarker, possibly reflecting chondrocyte damage. Whether serum urate (sUA) levels reflect/contribute to OA is unknown. We investigated whether sUA predicts OA progression in a non-gout knee OA population. METHODS: Eighty-eight subjects with medial knee OA (BMI <33) but without gout were included. Baseline sUA was measured in previously banked serum...
February 19, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28216313/between-group-differences-in-infra-patellar-fat-pad-size-and-signal-in-symptomatic-and-radiographic-progression-of-knee-osteoarthritis-vs-non-progressive-controls-and-healthy-knees-data-from-the-fnih-biomarkers-consortium-study-and-the-osteoarthritis-initiative
#2
Anja Ruhdorfer, Franziska Haniel, Tobias Petersohn, Jan Dörrenberg, Wolfgang Wirth, Torben Dannhauer, David J Hunter, Felix Eckstein
OBJECTIVE: To examine cross-sectional and longitudinal between-group differences of infra-patellar fat pad (IPFP) size and magnetic resonance imaging (MRI) signal from fat-suppressed intermediate-weighted images with clinically relevant symptomatic and radiographic progression of knee osteoarthritis (OA), versus healthy references. METHODS: We studied 110 case knees (KLG1-3) with radiographic (≥0.7mm loss in joint space width) and symptomatic progression (≥+9/100units on the WOMAC knee pain subscale) vs...
February 12, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28214084/il-10-and-tgf-%C3%AE-roles-in-chondroprotective-effects-of-glucosamine-in-experimental-osteoarthritis
#3
Nermien E Waly, Abeer Refaiy, Nora M Aborehab
OBJECTIVE: Osteoarthritis (OA) is a complex disease of the whole joint. Glucosamine (GlcN) treatment may have a chondroprotective effect on OA. We investigated the mechanism of action of glucosamine treatment through interleukin-10 (Il-10) and transforming growth factor β-1 (TGF β-1). METHODS: Thirty male albino rats were used. A single intraarticular (i.a.) injection of 2mg of Monosodium Iodoacetate (MIA) was injected into the knee joint of anesthetized rats...
February 11, 2017: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/28167869/bearings-in-hip-arthroplasty-joint-registries-vs-precision-medicine-review-article
#4
REVIEW
Mark J Pearson, Liam M Grover, Janet M Lord, Simon W Jones, Edward T Davis
BACKGROUND: Precision medicine has been adopted in a range of clinical settings where omics data have led to greater characterisation of disease and stratification of patients into subcategories of phenotypes and pathologies. However, in orthopaedics, precision medicine lags behind other disciplines such as cancer. Joint registries have now amassed a huge body of data pertaining to implant performance which can be broken down into performance statistics for different material types in different cohorts of patients...
February 2017: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
https://www.readbyqxmd.com/read/28164623/decreased-synovial-fluid-%C3%AE-melanocyte-stimulating-hormone-%C3%AE-msh-levels-reflect-disease-severity-in-patients-with-posttraumatic-ankle-osteoarthritis
#5
Guangyu Liu, Yunzhen Chen, Guichun Wang, Jianbing Niu
BACKGROUND: α-Melanocyte-stimulating hormone (α-MSH), an endogenous melanocortin peptide, has been demonstrated to have anti-inflammation effects and protect against cartilage damage. Objective In this study, we aimed to investigate whether α-MSH in ankle joint synovial fluid is associated with the disease severity of posttraumatic ankle osteoarthritis (PTAOA). METHODS: 66 PTAOA patients undergoing ankle arthroscopical debridement or ankle joint replacement were enrolled in the study...
August 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28153788/quantitative-measurement-of-medial-femoral-knee-cartilage-volume-analysis-of-the-oa-biomarkers-consortium-fnih-study-cohort
#6
L F Schaefer, M Sury, M Yin, S Jamieson, I Donnell, S E Smith, J A Lynch, M C Nevitt, J Duryea
OBJECTIVE: Large studies of knee osteoarthritis (KOA) require well-characterized efficient methods to assess progression. We previously developed the local-area cartilage segmentation (LACS) software method, to measure cartilage volume on magnetic resonance imaging (MRI) scans. The present study further validates this method in a larger patient cohort and assesses predictive validity in a case-control study. METHOD: The OA Biomarkers Consortium FNIH Project, a case-control study of KOA progression nested within the Osteoarthritis Initiative (OAI), includes 600 subjects in four subgroups based on radiographic and pain progression...
January 30, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28147215/attenuated-synovial-fluid-ghrelin-levels-are-linked-with-cartilage-damage-meniscus-injury-and-clinical-symptoms-in-patients-with-knee-anterior-cruciate-ligament-deficiency
#7
Yu-Cong Zou, Liang-Hua Chen, Yong-Liang Ye, Guang-Gang Yang, Zheng Mao, Dan-Dan Liu, Jun-Qi Chen, Jing-Jie Chen, Gang Liu
BACKGROUND: The meniscus injury and post-traumatic knee osteoarthritis (PTOA) following anterior cruciate ligament (ACL) lesions often cause great burdens to patients. Ghrelin, a recently identified 28-amino-acid peptide, has been shown to inhibit inflammation and perform as a growth factor for chondrocyte. OBJECTIVE: This study was aimed at investigating ghrelin concentration in synovial fluid and its association with the degree of meniscus injury, articular degeneration, and clinical severity in patients suffering from anterior cruciate ligament (ACL) deficiency...
December 2016: Discovery Medicine
https://www.readbyqxmd.com/read/28146402/a-multicenter-study-of-early-anti-inflammatory-treatment-in-patients-with-acute-anterior-cruciate-ligament-tear
#8
Christian Lattermann, Cale A Jacobs, Mary Proffitt Bunnell, Laura J Huston, Lee G Gammon, Darren L Johnson, Emily K Reinke, Janet L Huebner, Virginia B Kraus, Kurt P Spindler
BACKGROUND: It is increasingly recognized that biochemical abnormalities of the joint precede radiographic abnormalities of posttraumatic osteoarthritis (PTOA) by as much as decades. A growing body of evidence strongly suggests that the progression from anterior cruciate ligament (ACL) injury to PTOA is multifactorial, involving the interplay between biomechanical disturbances and biochemical homeostasis of articular cartilage. PURPOSE: The purposes of this randomized study using an acute ACL injury model were to (1) evaluate the natural progression of inflammatory and chondrodegenerative biomarkers, (2) evaluate the relationship between subjective reports of pain and inflammatory and chondrodegenerative biomarkers, and (3) determine if postinjury arthrocentesis and corticosteroid injection offer the ability to alter this biochemical cascade...
February 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28144827/biomarkers-for-musculoskeletal-pain-conditions-use-of-brain-imaging-and-machine-learning
#9
REVIEW
Jeff Boissoneault, Landrew Sevel, Janelle Letzen, Michael Robinson, Roland Staud
Chronic musculoskeletal pain condition often shows poor correlations between tissue abnormalities and clinical pain. Therefore, classification of pain conditions like chronic low back pain, osteoarthritis, and fibromyalgia depends mostly on self report and less on objective findings like X-ray or magnetic resonance imaging (MRI) changes. However, recent advances in structural and functional brain imaging have identified brain abnormalities in chronic pain conditions that can be used for illness classification...
January 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/28137664/comparing-intra-articular-ctxii-levels-assessed-via-magnetic-capture-or-lavage-in-a-rat-knee-osteoarthritis-model
#10
E G Yarmola, Y Y Shah, H E Kloefkorn, J Dobson, K D Allen
OBJECTIVE: Parallel measures of osteoarthritis (OA) pathogenesis across species can help researchers evaluate OA models relative to the human condition. Toward this need, our group recently developed a magnetic nanoparticle-based technology, termed magnetic capture, to analyze biomarkers within a rat knee. The objectives of this study were two-fold: (1) directly compare magnetic capture to lavage, and (2) assess c-telopeptide of collagen type II (CTXII) levels in the rat medial meniscus transection (MMT) model of knee OA...
January 28, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28123469/expression-of-hypoxia-inducible-factor-1%C3%AE-in-synovial-fluid-and-articular-cartilage-is-associated-with-disease-severity-in-knee-osteoarthritis
#11
Liming Qing, Pengfei Lei, Hao Liu, Jie Xie, Long Wang, Ting Wen, Yihe Hu
The aim of the present study was to examine hypoxia-inducible factor 1α (HIF-1α) levels in the synovial fluid and articular cartilage of patients with primary knee osteoarthritis (OA) and to investigate their association with the severity of disease. A total of 36 patients with knee OA and ten healthy controls were enrolled. Anteroposterior knee radiographs and/or Mankin scores were assessed to determine the disease severity of the affected knee. Radiographic grading of OA in the knee was performed according to Kellgren-Lawrence criteria...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28115232/identification-of-serological-biomarker-profiles-associated-with-total-joint-replacement-in-osteoarthritis-patients
#12
R H G P Arends, M A Karsdal, K M Verburg, C R West, A C Bay-Jensen, D S Keller
OBJECTIVE: Establish a biomarker panel associated with all-cause total joint replacement (TJR) through identification of patients with osteoarthritis (OA) who do or do not progress to TJR and investigate effects of nonsteroidal anti-inflammatory drugs (NSAIDs). DESIGN: Serum samples from patients enrolled in phase III trials of tanezumab who experienced TJR (n = 174) or matched patients who did not (n = 321) were analyzed for bone, cartilage, soft tissue, and inflammation markers...
January 21, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28112495/design-of-the-mobility-and-independent-living-in-elders-study-an-older-adult-cohort-in-rural-india
#13
Tushar Singh, Pawan K Sharma, Guru Rajesh Jammy, Jane A Cauley, Clareann H Bunker, P S Reddy, Anne B Newman
AIM: The Mobility and Independent Living in Elders Study (MILES) was established in 2012 to estimate the prevalence, incidence, and risk factors for disability and age-related disease in rural older Indians. Here we describe the main goals of MILES, the essential elements of its design and examinations, and the initial findings from the baseline visit. METHODS: A random sample of 562 men and women aged ≥60 years was enrolled from the Medchal region in Telangana State...
January 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28111965/identification-of-cd4-t-cell-derived-cd161-cd39-and-cd39-cd73-microparticles-as-new-biomarkers-for-rheumatoid-arthritis
#14
Wenqiang Fan, Wenxiang Wang, Jie Wu, Ling Ma, Jinyan Guo
AIM: This study aimed to identify CD4(+) T-cell-derived microparticles (MPs) and investigate their roles in rheumatoid arthritis (RA). METHODS: Synovial fluids from 34 RA, 33 osteoarthritis patients and 42 healthy individuals were analyzed by flow cytometry. Human fibroblast-like synoviocytes and peripheral blood mononuclear cells were cultured with or without isolated MPs, chemokines and cytokines were measured by ELISA. RESULTS: CD4(+)CD161(+)CD39(+) and CD4(+)CD39(+)CD73(+) MPs were abundantly present in RA patients, which were positively or negatively correlated with RA features, respectively...
February 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28101186/comparative-analysis-of-signaling-pathways-in-peripheral-blood-from-patients-with-kashin-beck-disease-and-osteoarthritis
#15
Yujie Ning, Xi Wang, Sen Wang, Xiong Guo
The aim of the present study was to investigate the early diagnostic biomarkers of Kashin-Beck disease (KBD), and to compare the common signaling pathways of peripheral mononuclear cells between patients with KBD and those with osteoarthritis (OA). A total of 20 and 12 peripheral blood samples were separately collected from KBD patients and normal control subjects, respectively, in an endemic area according to the diagnosis criteria. Total RNAs were extracted and gene expression levels were determined using an Agilent whole genome expression microarrays...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28101145/impact-of-physical-activity-and-mechanical-loading-on-biomarkers-typically-used-in-osteoarthritis-assessment-current-concepts-and-knowledge-gaps
#16
REVIEW
Nicole M Cattano, Jeffrey B Driban, Kenneth L Cameron, Michael R Sitler
There is an ongoing need to develop prognostic and diagnostic biomarkers for osteoarthritis (OA). Understanding how biomarkers change in response to physical activity may be vital for understanding if a patient has a joint that is failing to adapt to a given loading stimulus. The purpose of this review is to describe how biomarker changes after joint loading may help detect early OA and determine prognosis. This may help to inform and more specifically target interventions and clinical trials. We conducted a critical review of the relevant literature that was published to January 2016...
January 2017: Therapeutic Advances in Musculoskeletal Disease
https://www.readbyqxmd.com/read/28099838/osteoarthritis-year-in-review-2016-biomarkers-biochemical-markers
#17
REVIEW
A Mobasheri, A-C Bay-Jensen, W E van Spil, J Larkin, M C Levesque
PURPOSE: The aim of this "Year in Review" article is to summarize and discuss the implications of biochemical marker related articles published between the Osteoarthritis Research Society International (OARSI) 2015 Congress in Seattle and the OARSI 2016 Congress in Amsterdam. METHODS: The PubMed/MEDLINE bibliographic database was searched using the combined keywords: 'biomarker' and 'osteoarthritis'. The PubMed/MEDLINE literature search was conducted using the Advanced Search Builder function (http://www...
February 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28097685/cartilage-oligomeric-matrix-protein-comp-neo-epitope-in-the-synovial-fluid-of-horses-with-acute-lameness-a-new-biomarker-for-the-early-stages-of-osteoarthritis
#18
E Skiöldebrand, S Ekman, L MattssonHultén, E Svala, K Björkman, A Lindahl, A Lundqvist, P Önnerfjord, C Sihlbom, U Rüetschi
BACKGROUND: Clinical tools to diagnose the early changes of osteoarthritis (OA) that occur in the articular cartilage are lacking. OBJECTIVES: We sought to identify and quantify a novel cartilage oligomeric matrix protein (COMP) neo-epitope in the synovial fluid from the joints of healthy horses and those with different stages of OA. STUDY DESIGN: In vitro quantitative proteomics and assay development with application in synovial fluids samples obtained from biobanks of well-characterised horses...
January 17, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28091618/chemical-isotope-labeling-lc-ms-for-monitoring-disease-progression-and-treatment-in-animal-models-plasma-metabolomics-study-of-osteoarthritis-rat-model
#19
Deying Chen, Xiaoling Su, Nan Wang, Yunong Li, Hua Yin, Liang Li, Lanjuan Li
We report a chemical isotope labeling (CIL) liquid chromatography mass spectrometry (LC-MS) method generally applicable for tracking metabolomic changes from samples collected in an animal model for studying disease development and treatment. A rat model of surgically induced osteoarthritis (OA) was used as an example to illustrate the workflow and technical performance. Experimental duplicate analyses of 234 plasma samples were carried out using dansylation labeling LC-MS targeting the amine/phenol submetabolome...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28091549/urinary-proteomics-can-define-distinct-diagnostic-inflammatory-arthritis-subgroups
#20
Stefan Siebert, Duncan Porter, Caron Paterson, Rosie Hampson, Daniel Gaya, Agnieszka Latosinska, Harald Mischak, Joost Schanstra, William Mullen, Iain McInnes
Current diagnostic tests applied to inflammatory arthritis lack the necessary specificity to appropriately categorise patients. There is a need for novel approaches to classify patients with these conditions. Herein we explored whether urinary proteomic biomarkers specific for different forms of arthritis (rheumatoid arthritis (RA), psoriatic arthritis (PsA), osteoarthritis (OA)) or chronic inflammatory conditions (inflammatory bowel disease (IBD)) can be identified. Fifty subjects per group with RA, PsA, OA or IBD and 50 healthy controls were included in the study...
January 16, 2017: Scientific Reports
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