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Ashwagandha

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https://www.readbyqxmd.com/read/29392963/antioxidant-activity-and-apoptotic-induction-as-mechanisms-of-action-of-withania-somnifera-ashwagandha-against-a-hepatocellular-carcinoma-cell-line
#1
Wafaa Ahmed, Dina Mofed, Abdel-Rahman Zekri, Nasr El-Sayed, Mohamed Rahouma, Salwa Sabet
Objective To evaluate the antioxidant and apoptotic inductive effects of Withania somnifera (Ashwagandha) leaf extract against a hepatocellular carcinoma cell line. Methods After treating HepG2cells with Ashwagandha water extract (ASH-WX; 6.25 mg/ml-100 mg/ml), cell proliferation was assessed using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Antioxidant activities (total antioxidant, glutathione S-transferase and glutathione reductase), Fas-ligand level, tumour necrosis factor-α (TNF-α) level and caspase-3, -8, and -9 activities were measured...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29391697/insights-into-bovine-endometritis-with-special-reference-to-phytotherapy
#2
REVIEW
Ritika Mandhwani, Anavil Bhardwaz, Sudarshan Kumar, Madhu Shivhare, Ranjit Aich
Postpartum reproductive disorders cause heavy economic losses in dairy sector. Uterine infections include endometritis, metritis, mucometra, and pyometra. Postpartum endometritis in dairy cows has been defined as inflammation of endometrium occurring 21 days or more after parturition without systemic signs of illness. The treatment of endometritis with antimicrobials has met with varying degrees of success, inconsistent recovery rate, high cost of treatment, milk disposal, emergence of microbial resistance, and reduced phagocytic activity of polymorphonuclear leukocytes In our country, around 20,000 medicinal plant species have been recorded, but more than 500 traditional communities use about 800 plant species for curing different diseases...
December 2017: Veterinary World
https://www.readbyqxmd.com/read/29277366/role-of-withania-somnifera-ashwagandha-in-the-management-of-male-infertility
#3
REVIEW
Pallav Sengupta, Ashok Agarwal, Maria Pogrebetskaya, Shubhadeep Roychoudhury, Damayanthi Durairajanayagam, Ralf Henkel
To manage male infertility caused by hormonal imbalance, infections and other predicaments, multifarious treatment strategies are emerging worldwide. Contemporary treatments, such as assisted reproductive techniques, are costly with low success rates of only 10-30%; however, herbal remedies are gaining more attention as an alternative or supplementary therapeutic modality for male infertility. The beneficial effects induced by oral intake of the roots of a small evergreen shrub, Withania sominifera (Ashwagandha) on semen quality of infertile men have previously been studied...
December 7, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29207843/biosynthesis-characterization-and-antibacterial-efficacy-of-silver-nanoparticles-derived-from-endophytic-fungi-against-p-gingivalis
#4
Kiran Rahul Halkai, Jayashree A Mudda, Vasundhara Shivanna, Vandana Rathod, Rahul S Halkai
Introduction: Microbial resistance to existing antimicrobial agents in periodontal therapy is a growing problem. Therefore, there is a need for development of new antimicrobial agents. Aim: To biosynthesize and characterize Silver Nanoparticles (AgNPs) using endophytic fungi and to evaluate the antibacterial efficacy against P. gingivalis. Materials and Methods: Cut leaf segments of Withania Somnifera (Ashwagandha) were used to isolate the fungi...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29192149/transcription-factor-repertoire-in-ashwagandha-withania-somnifera-through-analytics-of-transcriptomic-resources-insights-into-regulation-of-development-and-withanolide-metabolism
#5
Sandhya Tripathi, Rajender Singh Sangwan, Lokesh Kumar Narnoliya, Yashdeep Srivastava, Bhawana Mishra, Neelam Singh Sangwan
Transcription factors (TFs) are important regulators of cellular and metabolic functions including secondary metabolism. Deep and intensive RNA-seq analysis of Withania somnifera using transcriptomic databases provided 3532 annotated transcripts of transcription factors in leaf and root tissues, belonging to 90 different families with major abundance for WD-repeat (174 and 165 transcripts) and WRKY (93 and 80 transcripts) in root and leaf tissues respectively, followed by that of MYB, BHLH and AP2-ERF. Their detailed comparative analysis with Arabidopsis thaliana, Capsicum annum, Nicotiana tabacum and Solanum lycopersicum counterparts together gave interesting patterns...
November 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29168225/gaba-modulating-phytomedicines-for-anxiety-a-systematic-review-of-preclinical-and-clinical-evidence
#6
REVIEW
Karen Savage, Joseph Firth, Con Stough, Jerome Sarris
Anxiety disorders are chronic and functionally disabling conditions with high psychological stress, characterised by cognitive symptoms of excessive worry and focus difficulties and physiological symptoms such as muscle tension and insomnia. Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter within the central nervous system and is a key target of pharmacotherapies in the treatment of anxiety. Although current pharmaceutical treatments are often efficacious, they may cause undesirable side effects including cognitive decrements and withdrawal symptoms...
November 23, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29152258/in-vitro-screening-of-neuroprotective-activity-of-indian-medicinal-plant-withania-somnifera
#7
Manjeet Singh, Charles Ramassamy
Canine cognitive dysfunction (CCD) is an age-dependent neurodegenerative condition characterised by changes in decline in learning and memory patterns. The neurodegenerative features of CCD in ageing dogs and cats are similar to human ageing and Alzheimer's disease (AD). Discovering neuroprotective disease-modifying therapies against CCD and AD is a major challenge. Strong evidence supports the role of amyloid β peptide deposition and oxidative stress in the pathophysiology of CCD and AD. In both the human and canine brain, oxidative damage progressively increases with age...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/29133027/nutrient-analysis-of-kunapa-jala-and-pancha-gavya-and-their-evaluation-on-germination-of-ashwagandha-withania-somnifera-dunal-and-kalamegha-andrographis-paniculata-nees-seeds-a-comparative-study
#8
Gireesh M Ankad, Jagadishchandra Hiremath, R T Patil, H J Pramod, Harsha V Hegde
BACKGROUND: Vrikshayurveda, an ancient science of plant life described by Surapala, deals with healthy growth and productivity of plants, which has clearly outlined a systematized agricultural practice that insisted the use of Kunapa jala (KJ) and Pancha gavya (PG). OBJECTIVE: An experiment was conducted to validate KJ and PG by nutrient analysis and their effect on the germination parameters of Ashwagandha and Kalamegha seeds in comparison with other treatment groups...
November 10, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/28829155/efficacy-and-safety-of-ashwagandha-root-extract-in-subclinical-hypothyroid-patients-a-double-blind-randomized-placebo-controlled-trial
#9
Ashok Kumar Sharma, Indraneel Basu, Siddarth Singh
BACKGROUND: Subclinical hypothyroidism, a thyroid disorder without obvious symptoms of thyroid deficiency, occurs in 3%-8% of the global population. Ashwagandha [Withania somnifera (L.) Dunal], a traditional medicine in Ayurveda, is often prescribed for thyroid dysfunctions. OBJECTIVE: This pilot study was designed to evaluate the efficacy and safety of ashwagandha root extract in subclinical hypothyroid patients. DESIGN, SETTING, AND PARTICIPANTS: A prospective, randomized, double-blind, single-center placebo-controlled study was performed at Sudbhawana Hospital, Varanasi, India between May 2016 and September 2016...
August 22, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28713602/treatment-of-nonclassic-11-hydroxylase-deficiency-with-ashwagandha-root
#10
Daniel Powell, Taiga Inoue, Gül Bahtiyar, Gabriel Fenteany, Alan Sacerdote
An elderly woman presented with acne and male pattern alopecia, which upon diagnostic evaluation was found to be due to nonclassic 11-hydroxylase deficiency. We previously reported that Ashwagandha root ameliorates nonclassic 3-β-ol dehydrogenase and aldosterone synthase deficiencies. This is the first report of its use being associated with amelioration of nonclassic 11-hydroxylase deficiency, where its apparent effects appear to be dose-related.
2017: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/28706332/role-of-elsholtzia-communis-in-counteracting-stress-by-modulating-expression-of-hspa14-c-ebp-homologous-protein-nuclear-factor-erythroid-derived-2-like-2-factor-caspase-3-and-brain-derived-neurotrophic-factor-in-rat-hippocampus
#11
Chandana Choudhury Barua, Pompy Patowary, Arundhati Purkayastha, Prakash Haloi, Manab Jyoti Bordoloi
OBJECTIVE: Elsholtzia communis (Collett and Hemsl.) Diels has been widely distributed and is reported for many therapeutic effects. The present study aims to investigate the antistress activity of the leaf extract and its possible molecular mechanism. MATERIALS AND METHODS: Hydroethanolic extract of leaves of E. communis (100 and 200 mg/kg, p.o.) were administered for 7 days to stress-induced male Wistar rats. The experimental animals were divided into five groups (n = 6)...
March 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28553006/determination-of-mycotoxins-alkaloids-phytochemicals-antioxidants-and-cytotoxicity-in-asiatic-ginseng-ashwagandha-dong-quai-panax-ginseng
#12
Anna Filipiak-Szok, M Kurzawa, E Szłyk, M Twarużek, A Błajet-Kosicka, J Grajewski
Mycotoxins and selected hazardous alkaloids in the medicinal plants (Panax ginseng, Angelica sinensis, and Withania somnifera) and dietary supplements were determined. Purine alkaloids were found in majority of samples; however, isoquinoline alkaloids were less abundant than indole. The predominant alkaloids appear to be caffeine (purine group), harman (indole group) and berberine (isoquinoline). Examined medicinal plants and dietary supplements were contaminated by mycotoxins (especially ochratoxin A 1.72-5...
2017: Chemické Zvesti
https://www.readbyqxmd.com/read/28526626/longevity-and-healthy-ageing-genes-foxo3a-and-sirt3-serum-protein-marker-and-new-road-map-to-burst-oxidative-stress-by-withania-somnifera
#13
Rashmita Pradhan, Rahul Kumar, Shashank Shekhar, Nitish Rai, Akash Ambashtha, Joyita Banerjee, Mona Pathak, S N Dwivedi, Sharmistha Dey, Aparajit B Dey
BACKGROUND: Ageing process is characterized by a decline in function; different age related diseases and excessive age associated mortality. There has always been a quest for easily accessible biomarkers to monitor and identify the development of age-associated stress for providing new anti-ageing strategies. Forkhead box protein O3A (FOXO3A) and Sirtuin3 (SIRT3) are such potential markers which plays important role in a wide variety of cellular mechanisms and has been proposed to be an ideal candidate to study longevity and are potential candidate for healthy ageing by oxidative burst...
September 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28479732/effect-of-a-novel-ashwagandha-based-herbomineral-formulation-on-pro-inflammatory-cytokines-expression-in-mouse-splenocyte-cells-a-potential-immunomodulator
#14
Mahendra Kumar Trivedi, Sambhu Charan Mondal, Mayank Gangwar, Snehasis Jana
BACKGROUND: Herbomineral formulations are momentous in an audience of worldwide by virtue of their holistic approach to life. These formulations are widely used as complementary therapies in immunocompromised patients including cancer. Still, there is the need of cost-effective and safe herbomineral-based formulation that can modulate immune response by the regulation of cytokines cascades. OBJECTIVE: Current study, we investigated immunomodulatory effect of TEBEH in LPS-induced cytokines expression levels in mouse splenocytes in vitro...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28471731/efficacy-and-safety-of-ashwagandha-withania-somnifera-l-dunal-root-extract-in-improving-memory-and-cognitive-functions
#15
Dnyanraj Choudhary, Sauvik Bhattacharyya, Sekhar Bose
OBJECTIVES: Cognitive decline is often associated with the aging process. Ashwagandha (Withania somnifera (L.) Dunal) has long been used in the traditional Ayurvedic system of medicine to enhance memory and improve cognition. AIM: This pilot study was designed to evaluate the efficacy and safety of ashwagandha (Withania somnifera (L.) Dunal) in improving memory and cognitive functioning in adults with mild cognitive impairment (MCI). METHODS: A prospective, randomized, double-blind, placebo-controlled study was conducted in 50 adults...
November 2, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28425984/withaferin-a-kills-cancer-cells-with-and-without-telomerase-chemical-computational-and-experimental-evidences
#16
Yue Yu, Shashank P Katiyar, Durai Sundar, Zeenia Kaul, Eijiro Miyako, Zhenya Zhang, Sunil C Kaul, Roger R Reddel, Renu Wadhwa
Maintenance of telomere length is the most consistent attribute of cancer cells. Tightly connected to their capacity to overcome replicative mortality, it is achieved either by activation of telomerase or an Alternative mechanism of Lengthening of Telomeres (ALT). Disruption of either of these mechanisms has been shown to induce DNA damage signalling leading to senescence or apoptosis. Telomerase inhibitors are considered as potential anticancer drugs but are ineffective for ALT cancers (~15% of all cancers)...
April 20, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28377654/a-comparative-study-of-ion-diffusion-from-calcium-hydroxide-with-various-herbal-pastes-through-dentin
#17
Priyanka Dausage, Rajesh B Dhirawani, Jayant Marya, Vrinda Dhirawani, Vijayendra Kumar
AIM: The aim of this study was to evaluate the diffusion ability of ions through dentinal tubules of different nonalcoholic calcium hydroxide-containing herbal pastes and compare it with the calcium hydroxide paste prepared with saline. MATERIALS AND METHODS: A total of 36 single-rooted premolar teeth were used in this study. The tooth crowns were removed and the root canals were prepared. Depending on the vehicle to be used for preparing calcium hydroxide pastes, six groups were made: Group I: Ca(OH)2 saline paste (control group), group II: Ca(OH)2 papaya latex paste, group III: Ca(OH)2 coconut water paste, group IV: Ca(OH)2 Ashwagandha (Withania somnifera) paste, group V: Ca(OH)2 Tulsi (Ocimum tenuiflorum) paste, and group VI: Ca(OH)2 garlic (Allium sativum) paste...
January 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28285113/ayurvedic-management-in-cervical-spondylotic-myelopathy
#18
Sarvesh Kumar Singh, Kshipra Rajoria
The age related spondylotic changes may result in direct compressive and ischemic dysfunction of the spinal cord known as cervical spondylotic myelopathy (CSM). Symptoms often develop insidiously and are characterized by neck stiffness, unilateral or bilateral deep aching neck, arm and shoulder pain, and possibly stiffness or clumsiness while walking. The management available in current mainstream medicine is not satisfactory. Various Ayurvedic treatments have been in use for these manifestations. We present a case of CSM, which was treated with a combination of Panchakarma procedures and Ayurvedic oral drugs...
January 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/28253924/withania-somnifera-leaf-alleviates-cognitive-dysfunction-by-enhancing-hippocampal-plasticity-in-high-fat-diet-induced-obesity-model
#19
Shaffi Manchanda, Gurcharan Kaur
BACKGROUND: Sedentary lifestyle, psychological stress and labor saving devices in this current society often disrupts the energy gain and expenditure balance leading to obesity. High caloric diet is associated with the high prevalence of cognitive dysfunction and neuropsychiatric disorders in addition to cardiovascular and metabolic abnormalities. The present study was aimed to elucidate the potential beneficial effect of dry leaf powder of Withania somnifera (Ashwagandha) in preventing the cognitive decline associated with diet induced obesity...
March 3, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28249222/comparative-study-of-withanolide-production-and-the-related-transcriptional-responses-of-biosynthetic-genes-in-fungi-elicited-cell-suspension-culture-of-withania-somnifera-in-shake-flask-and-bioreactor
#20
COMPARATIVE STUDY
Seema Ahlawat, Parul Saxena, Athar Ali, Shazia Khan, Malik Z Abdin
Ashwagandha (Withania somnifera) is one of the most reputed medicinal plants in the traditional medicinal system. In this study, cell suspension culture of W. somnifera was elicited with cell homogenates of fungi (A. alternata, F. solani, V. dahliae and P. indica) in shake flask and the major withanolides like withanolide A, withaferin A and withanone were analysed. Simultaneously expression levels of key pathway genes from withanolides biosynthetic pathways were also checked via quantitative PCR in shake flask as well as in bioreactor...
May 2017: Plant Physiology and Biochemistry: PPB
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