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Ashwagandha

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https://www.readbyqxmd.com/read/27928708/withania-somnifera-reverses-transactive-response-dna-binding-protein-43-proteinopathy-in-a-mouse-model-of-amyotrophic-lateral-sclerosis-frontotemporal-lobar-degeneration
#1
Kallol Dutta, Priyanka Patel, Reza Rahimian, Daniel Phaneuf, Jean-Pierre Julien
Abnormal cytoplasmic mislocalization of transactive response DNA binding protein 43 (TARDBP or TDP-43) in degenerating neurons is a hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U). Our previous work suggested that nuclear factor kappa B (NF-κB) may constitute a therapeutic target for TDP-43-mediated disease. Here, we investigated the effects of root extract of Withania somnifera (Ashwagandha), an herbal medicine with anti-inflammatory properties, in transgenic mice expressing a genomic fragment encoding human TDP-43(A315T) mutant...
December 7, 2016: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/27846826/natural-product-htp-screening-for-antibacterial-e-coli-0157-h7-and-anti-inflammatory-agents-in-lps-from-e-coli-o111-b4-activated-macrophages-and-microglial-cells-focus-on-sepsis
#2
Elizabeth A Mazzio, Nan Li, David Bauer, Patricia Mendonca, Equar Taka, Mohammed Darb, Leeshawn Thomas, Henry Williams, Karam F A Soliman
BACKGROUND: Acute systemic inflammatory response syndrome arising from infection can lead to multiple organ failure and death, with greater susceptibility occurring in immunocompromised individuals. Moreover, sub-acute chronic inflammation is a contributor to the pathology of diverse degenerative diseases (Parkinson's disease, Alzheimer's disease and arthritis). Given the known limitations in Western medicine to treat a broad range of inflammatory related illness as well as the emergence of antibiotic resistance, there is a renewed interest in complementary and alternative medicines (CAMs) to achieve these means...
November 15, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27837436/withaferin-a-and-its-potential-role-in-glioblastoma-gbm
#3
REVIEW
Jasdeep Dhami, Edwin Chang, Sanjiv S Gambhir
Within the Ayurvedic medical tradition of India, Ashwagandha (Withania somnifera) is a well-known herb. A large number of withanolides have been isolated from both its roots and its leaves and many have been assessed for their pharmacological activities. Amongst them, Withaferin A is one of its most bioactive phytoconstituents. Due to the lactonal steroid's potential to modulate multiple oncogenic pathways, Withaferin A has gained much attention as a possible anti-neoplastic agent. This review focuses on the use of Withaferin A alone, or in combination with other treatments, as a newer option for therapy against the most aggressive variant of brain tumors, Glioblastoma...
November 11, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27743505/metabolite-profiling-of-withania-somnifera-roots-hydroalcoholic-extract-using-lc-ms-gc-ms-and-nmr-spectroscopy
#4
Mahendra Kumar Trivedi, Parthasarathi Panda, Kalyan Kumar Sethi, Snehasis Jana
Ashwagandha (Withania somnifera) is a very well-known herbal medicine and it was well studied for its active metabolites throughout the World. Although, nearly 40 withanolides were isolated from W. somnifera root extract, still there is remaining unidentified metabolites due to very low abundance and natural variation. Advanced separation technology with online identification by mass and nuclear magnetic resonance (NMR) are now-a-days used to find out the new compounds in the crude herbal extract. This article described the metabolite profiling of ashwagandha root hydroalcoholic extract using ultra-performance liquid chromatography coupled with a positive ion electrospray ionization tandem mass spectrometry through gas chromatography mass spectrometry (GC-MS) and NMR analysis...
October 15, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27685355/phospholipid-complexation-of-nmitli118rt-way-to-a-prudent-therapeutic-approach-for-beneficial-outcomes-in-ischemic-stroke-in-rats
#5
Hafsa Ahmad, Abhishek Arya, Satish Agrawal, Sheeba Saji Samuel, Sandeep Kumar Singh, Guru Raghavendra Valicherla, Neelam Sangwan, Kalyan Mitra, Jiaur R Gayen, Sarwesh Paliwal, Rakesh Shukla, Anil Kumar Dwivedi
Withania somnifera Dunal (Solanaceae) known as Ashwagandha, a popular plant of Indian origin is known to possess tremedous medicinal potential, often used as anti-inflammatory, anti-platelet, antihypertensive, hypoglycemic, hypolipidemic and adaptogenic candidate. Some of its chemotypes developed by CSIR, India includes NMITLI-101, NMITLI-118, NMITLI-128. In this study the investigators have attempted development of a phytosomal complex of NMITLI118RT + (standardized ethanolic extract of a new chemotype of W...
November 2016: Drug Delivery
https://www.readbyqxmd.com/read/27651261/indian-herbs-for-the-treatment-of-neurodegenerative-disease
#6
Padmanabhan Mannangatti, Kamalakkannan Narasimha Naidu
Ayurveda, an ancient system of medicine that is indigenous to India, is believed to be the world's oldest comprehensive health-care system and is now one of the most recognized and widely practiced disciplines of alternative medicine in the world. Medicinal herbs have been in use for treating diseases since ancient times in India. Ayurvedic therapies with medicinal herbs and herbomineral products generally provide relief without much adverse effects even after prolonged administration. Neurodegenerative disorders are a major cause of mortality and disability, and increasing life spans represent one of the key challenges of medical research...
2016: Advances in Neurobiology
https://www.readbyqxmd.com/read/27647956/assessment-of-cholinergic-properties-of-ashwagandha-leaf-extract-in-the-amnesic-mouse-brain
#7
Akash Gautam, Renu Wadhwa, Mahendra K Thakur
BACKGROUND: In our earlier study, we have shown the memory enhancing and scopolamine-induced amnesia recovery properties of Ashwagandha leaf extract using behavioral paradigm and expression analysis of synaptic plasticity genes. PURPOSE: However, the exact mechanism through which Ashwagandha demonstrates these effects is still unknown. METHODS: In the present study, we hypothesized that the alcoholic extract of Ashwagandha leaves (i-Extract) possesses cholinergic properties, which in turn inhibit the anti-cholinergic nature of scopolamine...
July 2016: Annals of Neurosciences
https://www.readbyqxmd.com/read/27647541/a-randomized-double-blind-placebo-controlled-study-of-efficacy-and-tolerability-of-withaina-somnifera-extracts-in-knee-joint-pain
#8
G S H Ramakanth, C Uday Kumar, P V Kishan, P Usharani
BACKGROUND: Root extracts of Withania somnifera (Ashwagandha) are known to possess analgesic, anti-inflammatory and chondroprotective effects. An aqueous extract of roots plus leaves of this plant has shown to yield higher percentages of withanolide glycosides and, accordingly, may possess better analgesic, anti-inflammatory and chondroprotective effects than root alone extracts. OBJECTIVES: To evaluate efficacy and tolerability of a standardized aqueous extract of roots plus leaves of W...
July 2016: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/27561457/comparative-evaluation-of-the-sexual-functions-and-nf-%C3%AE%C2%BAb-and-nrf2-pathways-of-some-aphrodisiac-herbal-extracts-in-male-rats
#9
Kazim Sahin, Cemal Orhan, Fatih Akdemir, Mehmet Tuzcu, Hasan Gencoglu, Nurhan Sahin, Gaffari Turk, Ismet Yilmaz, Ibrahim H Ozercan, Vijaya Juturu
BACKGROUND: Mucuna pruriens, Tribulus terrestris and Ashwagandha (Withania somnifera) are widely known as antioxidant effective herbals and have been reported to possess aphrodisiac activities in traditional usages. In this study, we determined the effects of these herbals on sexual functions, serum biochemical parameters, oxidative stress and levels of NF-κB, Nrf2, and HO-1 in reproductive tissues. METHODS: Thirty-five male rats were divided into five groups: the control group, sildenafil-treated group (5 mg/kg/d), Mucuna, Tribulus and Ashwagandha groups...
2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27550017/aqueous-extract-from-the-withania-somnifera-leaves-as-a-potential-anti-neuroinflammatory-agent-a-mechanistic-study
#10
Muskan Gupta, Gurcharan Kaur
BACKGROUND: Microglial-mediated neuroinflammation is a key factor underlying the pathogenesis of various neurodegenerative diseases and also an important target for the development of the neuroinflammation-targeted therapeutics. Conventionally, the nonsteroidal anti-inflammatory drugs (NSAIDs) are prescribed, but they are associated with long-term potential risks. Natural products are the cornerstone of modern therapeutics, and Ashwagandha is one such plant which is well known for its immunomodulatory properties in Ayurveda...
2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27515872/evaluation-of-the-efficacy-of-withania-somnifera-ashwagandha-root-extract-in-patients-with-obsessive-compulsive-disorder-a-randomized-double-blind-placebo-controlled-trial
#11
Seyedeh Pardis Jahanbakhsh, Ali Akhondpour Manteghi, Seyed Ahmad Emami, Saman Mahyari, Beheshteh Gholampour, Amir Hooshang Mohammadpour, Amirhossein Sahebkar
BACKGROUND: Obsessive-compulsive disorder (OCD) is a chronic psychiatric disorder that is causally linked to dysregulation of the serotonergic system. The aim of this study is to investigate the efficacy of Withania somnifera (W. somnifera) root extract as an adjunct therapy to standard OCD treatment. METHODS: Thirty patients with a confirmed diagnosis of OCD according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) criteria participated in this randomized double-blind placebo-controlled trial and were randomly assigned to the treatment group (W...
August 2016: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/27487266/network-ethnopharmacological-evaluation-of-the-immunomodulatory-activity-of-withania-somnifera
#12
Uma Chandran, Bhushan Patwardhan
ETHNOPHARMACOLOGICAL RELEVANCE: Withania somnifera (L.) Dunal (Ashwagandha, WS) is one of the extensively explored Ayurvedic botanicals. Several properties including immunomodulation, anti-cancer and neuro-protection of the botanical have been reported. Even though, in indigenous medicine, WS is well known for its immunomodulatory activity, the molecular mechanism of immunomodulation has not been elucidated. AIM OF THE STUDY: This study aimed the evaluation of the immunomodulatory effect of WS using network ethnopharmacology technique to elucidate the in silico molecular mechanism...
July 31, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27313411/influence-of-lunar-cycles-on-growth-of-ashwagandha-withania-somnifera-l-dunal
#13
Swagata D Tavhare, K Nishteswar, Vinay J Shukla
INTRODUCTION: Ayurvedic classics have advocated to collect the medicinal plants according to part used and seasons in order to get desired pharmacological action and therapeutic benefits. The logic behind this principle is being validated by recent researches. AIM: To analyze the influence of lunar cycles on growth of Ashwagandha in Shishira and Greeshma Ritu (winter and summer season). MATERIALS AND METHODS: Fourteen small crops of Ashwagandha of average size 10 cm were collected on October 7, 2013, from institute campus and then replantation was done at Charaka Herbal Garden, Gujarat Ayurved University, Jamnagar in an area of 60 cm × 60 cm (l × b)...
July 2015: Ayu
https://www.readbyqxmd.com/read/27279696/effect-of-withinia-somnifera-and-shilajit-on-alcohol-addiction-in-mice
#14
Priya Bansal, Sugato Banerjee
BACKGROUND: Alcohol addiction is a social problem leading to both loss of health and economic prosperity among addicted individuals. Common properties of anti-addictive compounds include anti-anxiety, anticonvulsants, anti-depressant, and nootropic actions primarily through modulation of gamma-aminobutyric acid (GABA) and serotonergic systems. OBJECTIVE: Here, we screen ashwagandha and shilajit known ethnopharmacologically as nervine tonic and adaptogenic herbs for possible anti-addictive potential...
May 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27209361/withania-somnifera-and-its-withanolides-attenuate-oxidative-and-inflammatory-responses-and-up-regulate-antioxidant-responses-in-bv-2-microglial-cells
#15
Grace Y Sun, Runting Li, Jiankun Cui, Mark Hannink, Zezong Gu, Kevin L Fritsche, Dennis B Lubahn, Agnes Simonyi
Withania somnifera (L.) Dunal, commonly known as Ashwagandha, has been used in Ayurvedic medicine for promoting health and quality of life. Recent clinical trials together with experimental studies indicated significant neuroprotective effects of Ashwagandha and its constituents. This study is aimed to investigate anti-inflammatory and anti-oxidative properties of this botanical and its two withanolide constituents, namely, Withaferin A and Withanolide A, using the murine immortalized BV-2 microglial cells...
September 2016: Neuromolecular Medicine
https://www.readbyqxmd.com/read/27166148/phytochemicals-and-botanical-extracts-regulate-nf-%C3%AE%C2%BAb-and-nrf2-are-reporter-activities-in-di-tnc1-astrocytes
#16
Deepa Ajit, Agnes Simonyi, Runting Li, Zihong Chen, Mark Hannink, Kevin L Fritsche, Valeri V Mossine, Robert E Smith, Thomas K Dobbs, Rensheng Luo, William R Folk, Zezong Gu, Dennis B Lubahn, Gary A Weisman, Grace Y Sun
The increase in oxidative stress and inflammatory responses associated with neurodegenerative diseases has drawn considerable attention towards understanding the transcriptional signaling pathways involving NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) and Nrf2 (Nuclear Factor Erythroid 2-like 2). Our recent studies with immortalized murine microglial cells (BV-2) demonstrated effects of botanical polyphenols to inhibit lipopolysaccharide (LPS)-induced nitric oxide (NO) and enhance Nrf2-mediated antioxidant responses (Sun et al...
July 2016: Neurochemistry International
https://www.readbyqxmd.com/read/27143799/effect-of-seasonal-variations-on-the-phytoconstituents-of-a%C3%A5-vagandh%C3%A4-w-r-to-lunar-cycles
#17
Swagata Dilip Tavhare, Karra Nishteswar, Vinay J Shukla
INTRODUCTION: Suśruta, Caraka and other ācāryas advocate the collection of medicinal plants keeping in view the part used, season, soil in which the herb grows and the desired pharmacological actions or therapeutic benefits. The logic behind such recommendations is being validated by modern scientific research. AIM: To assess the effect of seasonal variations on the phytoconstituents of Aśvagandhā (Withania somnifera L. Dunal) w.s.r. to lunar cycles. MATERIAL AND METHODS: The plant specimens were collected from Jamnagar identified pharmacognostically and cultivated under a defined habitat in a herbal garden of IPGT and RA on 7 Oct 2013...
January 2016: Ancient Science of Life
https://www.readbyqxmd.com/read/27110497/evaluation-and-comparison-of-the-in-vitro-cytotoxic-activity-of-withania-somnifera-methanolic-and-ethanolic-extracts-against-mda-mb-231-and-vero-cell-lines
#18
A N Srivastava, Rumana Ahmad, Mohsin Ali Khan
Withania somnifera Dunal (WS), commonly known as Ashwagandha in India, belongs to the family Solanaceae. It is extensively used in most of the Indian herbal pharmaceuticals and nutraceuticals. In the current study, the in vitro cytotoxic activity of methanolic, ethanolic, and aqueous extracts of WS stems was evaluated using cytometry and the MTT assay against the MDA-MB-231 human breast cancer cell line. Methanolic and ethanolic extracts of WS showed potent anticancer activity on the MDA-MB-231 human breast cancer cell line, whereas the aqueous extract did not exhibit any significant activity at 100 µg/ml...
January 2016: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/27108319/in-vitro-propagation-of-withania-somnifera-l-dunal
#19
Pritika Singh, Rupam Guleri, Pratap Kumar Pati
Withania somnifera (L.) Dunal known as Ashwagandha is commonly used in traditional Indian medicine system. It possesses immense therapeutic value against a large number of ailments such as mental diseases, asthma, inflammation, arthritis, rheumatism, tuberculosis, and a variety of other diseases including cancer. The therapeutic potential of W. somnifera is due to the presence of secondary metabolites mainly, tropane alkaloids and withanolides (steroidal lactones). The growing realization of commercial value of the plant has initiated a new demand for in vitro propagation of elite chemotypes of Withania...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27055824/body-weight-management-in-adults-under-chronic-stress-through-treatment-with-ashwagandha-root-extract-a-double-blind-randomized-placebo-controlled-trial
#20
Dnyanraj Choudhary, Sauvik Bhattacharyya, Kedar Joshi
Chronic stress has been associated with a number of illnesses, including obesity. Ashwagandha is a well-known adaptogen and known for reducing stress and anxiety in humans. The objective of this study was to evaluate the safety and efficacy of a standardized root extract of Ashwagandha through a double-blind, randomized, placebo-controlled trial. A total of 52 subjects under chronic stress received either Ashwagandha (300 mg) or placebo twice daily. Primary efficacy measures were Perceived Stress Scale and Food Cravings Questionnaire...
January 2017: Journal of Evidence-based Complementary & Alternative Medicine
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