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https://www.readbyqxmd.com/read/29679215/diagnostic-role-of-serum-tryptase-in-anaphylactic-deaths-in-forensic-medicine-a-systematic-review-and-meta-analysis
#1
REVIEW
Kai-Jian Sun, Jie-Tao He, Hong-Yan Huang, Ye Xue, Xiao-Li Xie, Qi Wang
Postmortem diagnosis of sudden death due to anaphylaxis can be very difficult due to the non-specific pathological findings in forensic practice. Postmortem serum tryptase has been used as an indicator of possible ante-mortem anaphylaxis. Though many previous studies have been conducted to explore the diagnostic significance of serum tryptase for lethal anaphylaxis, inconsistent results were documented. In this study, we made a retrospective study and presented a systematic review and meta-analysis that aims to summarize the diagnostic significance of postmortem serum tryptase in the deceased with and without anaphylactic shock and to calculate a cutoff value for future reference in the identification of deaths due to anaphylactic shock...
April 21, 2018: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/29679100/g-spotplasty-a-new-surgical-plastic-intervention-the-preliminary-study
#2
Adam Ostrzenski
BACKGROUND: Ostrzenski's G-pot anatomical structure discovery has been verified by the anatomy, histology, MRI in vivo, and electrovaginography in vivo studies. The objectives of this scientific-clinical investigation were to develop a new surgical reconstructive intervention (G-spotplasty); to determine the ability of G-spotplasty surgical implementation; to observe for potential complications; and to gather initial information on whether G-spotplasty improves female sexual activity, sexual behaviors, and sexual concerns...
April 20, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29678966/an-evaluation-of-prescribing-trends-and-patterns-of-claims-within-the-preferred-drugs-initiative-in-ireland-2011-2016-an-interrupted-time-series-study
#3
Ronald McDowell, Kathleen Bennett, Frank Moriarty, Sarah Clarke, Michael Barry, Tom Fahey
OBJECTIVE: To examine the impact of the Preferred Drugs Initiative (PDI), an Irish health policy aimed at enhancing evidence-based cost-effective prescribing, on prescribing trends and the cost of prescription medicines across seven medication classes. DESIGN: Retrospective repeated cross-sectional study spanning the years 2011 - 2016. SETTING: Health Service Executive Primary Care Reimbursement Service pharmacy claims data for General Medical Services (GMS) patients, approximately 40% of the Irish population...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678045/approach-towards-an-evidence-oriented-knowledge-and-data-acquisition-for-the-optimization-of-interdisciplinary-care-in-dentistry-and-general-medicine
#4
Max W Seitz, Christian Haux, Petra Knaup, Ingrid Schubert, Stefan Listl
Associations between dental and chronic-systemic diseases were observed frequently in medical research, however the findings of this research have so far found little relevance in everyday clinical treatment. Major problems are the assessment of evidence for correlations between such diseases and how to integrate current medical knowledge into the intersectoral care of dentists and general practitioners. On the example of dental and chronic-systemic diseases, the Dent@Prevent project develops an interdisciplinary decision support system (DSS), which provides the specialists with information relevant for the treatment of such cases...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677095/milling-the-mistletoe-nanotechnological-conversion-of-african-mistletoe-loranthus-micranthus-intoantimicrobial-materials
#5
Muhammad Sarfraz, Sharoon Griffin, Tamara Gabour Sad, Rama Alhasan, Muhammad Jawad Nasim, Muhammad Irfan Masood, Karl Herbert Schäfer, Chukwunonso E C C Ejike, Cornelia M Keck, Claus Jacob, Azubuike P Ebokaiwe
Nanosizing represents a straight forward technique to unlock the biological activity of complex plant materials. The aim of this study was to develop herbal nanoparticles with medicinal value from dried leaves and stems of Loranthus micranthus with the aid of ball-milling, high speed stirring, and high-pressure homogenization techniques. The milled nanoparticles were characterized using laser diffraction analysis, photon correlation spectroscopy analysis, and light microscopy. The average size of leaf nanoparticles was around 245 nm and that of stem nanoparticles was around 180 nm...
April 20, 2018: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29677043/the-effects-of-interprofessional-pediatric-end-of-life-simulation-on-communication-and-role-understanding-in-health-professions-students
#6
Jacqueline Stout-Aguilar, Alison Pittman, Regina Bentley, Jerry Livingston, Bree Watzak
The purpose of this study was to analyze the impact of interprofessional pediatric end-of life simulations for health professions students. A quasiexperimental design was used with three TeamSTEPPS® tools. Forty-one students were enrolled (nursing = 20, medicine = 10, pharmacy = 10, public health = 1). TeamSTEPPS 2.0 Teamwork Attitudes Questionnaire and Teamwork Perceptions Questionnaire analysis indicated a significant difference in mean pretest and posttest scores (p = .015 and p = .028, respectively). The Team Performance Observation Tool indicated statistical significance between simulations (p < ...
April 19, 2018: Nursing Education Perspectives
https://www.readbyqxmd.com/read/29676953/overinduction-of-the-cyp51a-gene-after-exposure-to-azole-antifungals-provides-a-first-clue-to-the-resistance-mechanism-in-the-fusarium-solani-species-complex
#7
Maurine D'Agostino, Thomas Lemmet, Claire Dufay, Amandine Luc, Jean Pol Frippiat, Marie Machouart, Anne Debourgogne
The genus Fusarium is largely represented in fungal infections, not only mostly in plants but also in humans. Fungi belonging to the Fusarium solani species complex (FSSC) are those that are most frequently isolated in invasive fusariosis and present elevated minimum inhibitory concentrations for the main antifungal drugs used in medicine. This study is the first to investigate the resistance mechanism in FSSC by monitoring CYP51A expression in the presence of azole antifungals. After exposure to voriconazole, an overinduction of CYP51A was observed irrespective of the concentration of antifungal used and the generation studied...
April 20, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29676768/exposure-of-bacillus-subtilis-to-silver-inhibits-activity-of-cytochrome-c-oxidase-in-vivo-via-interaction-with-sco-the-cu-a-assembly-protein
#8
Shina Hussain, Diann Andrews, Bruce C Hill
Silver has long been used as an antimicrobial agent in general and medicinal use. Here, we observe that exposure of the Gram-positive, endospore-forming bacterium Bacillus subtilis to Ag(i) effects growth in a biphasic manner. In the first phase at Ag(i) concentrations below 50 μM B. subtilis growth is not affected, but activity of the respiratory enzyme cytochrome c oxidase is disrupted completely. Between 50 to 100 μM Ag(i) B. subtilis growth is drastically diminished and completely absent above 100 μM Ag(i)...
April 20, 2018: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29676606/awareness-of-mutational-artefacts-in-suboptimal-dna-samples-possible-risk-for-therapeutic-choices
#9
Sara Mariani, Luca Bertero, Vittoria Coppola, Giorgio Saracco, Alberto Arezzo, Paola Francia di Celle, Jasna Metovic, Caterina Marchiò, Paola Cassoni
BACKGROUND: Technical biases due to PCR artefacts could represent an insidious obstacle for mutational analysis and precision medicine. METHODS: The authors report a retrospective analysis by fast COLD-PCR and sequencing of 31 suboptimal tumor DNA samples obtained from FFPE tissues and liquid biopsies. RESULTS: In FFPE tumor tissues and plasma liquid biopsies of patients with lung and colorectal adenocarcinoma, we observed a significant rate of artefactual KRAS mutations, unveiled by repeated analysis following UDG pretreatment as well as by simple repetition without UDG pretreatment step, thus suggesting a DNA damage different from cytosine deamination...
April 20, 2018: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/29674801/immunomodulatory-properties-of-titanium-dioxide-nanostructural-materials
#10
T Sree Latha, Madhava C Reddy, Prasad V R Durbaka, Shankar V Muthukonda, Dakshayani Lomada
OBJECTIVES: Although titanium dioxide (TiO2 ) nanostructural materials have been widely used in Biology and Medicine, very little is known about immunomodulation mechanism of these materials. Objectives of this study are to investigate in vitro immunomodulatory effects of TiO2 . Immunosuppressant may lower immune responses and are helpful for the treatment of graft versus host diseases and autoimmune disorders. MATERIALS AND METHODS: In this study, we used H2 Ti3 O7 titanium dioxide nanotubes (TNT) nanotubes along with commercial TiO2 nanoparticles (TNP) and TiO2 fine particles (TFP)...
November 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29674799/assessment-of-nonsteroidal-anti-inflammatory-drug-use-pattern-using-world-health-organization-indicators-a-cross-sectional-study-in-a-tertiary-care-teaching-hospital-of-chhattisgarh
#11
P R R Vaishnavi, Nitin Gaikwad, S P Dhaneria
OBJECTIVE: The objective of this study is to assess drug utilization pattern of nonsteroidal anti-inflammatory drugs (NSAIDs) in a tertiary care teaching hospital, Raipur, Chhattisgarh. MATERIALS AND METHODS: A prospective, cross-sectional observational study was conducted in the outpatient department during 2-month period. After informed consent, the patients visiting pharmacy shop with a prescription were enrolled in the study. Their demographic details and prescription data were recorded in a case record form...
November 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29674605/brain-training-games-enhance-cognitive-function-in-healthy-subjects
#12
Abdulrahman Al-Thaqib, Fahad Al-Sultan, Abdullah Al-Zahrani, Fahad Al-Kahtani, Khalid Al-Regaiey, Muhammad Iqbal, Shahid Bashir
BACKGROUND Brain training games (BTG) are believed to play a major role in improving cognitive functions. The current study evaluated if BTG showed positive impact on attention and memory functions compared with baseline visit in healthy subjects. MATERIAL AND METHODS The study was carried out from October 2015 until April 2016 in the Department of Physiology, College of Medicine, King Saud University and in King Khalid University Hospital (KKUH), Riyadh, Saudi Arabia. We enrolled 51 normal healthy subjects to use a computerized cognitive training game (Lumosity) for exercises that target a range of cognitive functions, including attention, processing speed, visual memory, and executive functions for about 15 min per day, at least 7 days per week, for 3 weeks...
April 20, 2018: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/29674282/bioenergetics-mechanisms-regulating-muscle-stem-cell-self-renewal-commitment-and-function
#13
REVIEW
Phablo Abreu
Muscle stem cells or satellite cells are crucial for muscle maintenance and repair. These cells are mitotically quiescent and uniformly express the transcription factor Pax7, intermittently entering the cell cycle to give rise to daughter myogenic precursors cells and fuse with neighboring myofibers or self-renew, replenishing the stem cell pool in adult skeletal muscle. Pivotal roles of muscle stem cells in muscle repair have been uncovered, but it still remains unclear how muscle stem cell self-renewal is molecularly regulated and how muscle stem cells maintain muscle tissue homeostasis...
April 16, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29673744/assessing-the-burden-of-abnormal-lfts-and-the-role-of-the-electronic-health-record-a-retrospective-study
#14
Andrew D Schreiner, Patrick D Mauldin, William P Moran, Valerie Durkalski-Mauldin, Jingwen Zhang, Samuel O Schumann, Marc E Heincelman, Justin Marsden, Don C Rockey
INTRODUCTION: Primary care clinicians encounter abnormal liver function tests (LFTs) frequently. This study assesses the prevalence of abnormal LFTs and patient follow-up patterns in response. METHODS: This is a retrospective study from 2007-2016 of adult patients with abnormal LFTs seen in an internal medicine clinic. The proportion of patients with follow-up testing and the time (in days) to repeat LFTs were the primary outcomes measured. Results were evaluated before and after the implementation of the institution's electronic health record (EHR)...
February 9, 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29673553/the-discoveries-of-molecular-mechanisms-for-the-circadian-rhythm-the-2017-nobel-prize-in-physiology-or-medicine
#15
Rong-Chi Huang
Circadian clocks evolved to allow plants and animals to adapt their behaviors to the 24-hr change in the external environment due to the Earth's rotation. While the first scientific observation of circadian rhythm in the plant leaf movement may be dated back to the early 18th century, it took 200 years to realize that the leaf movement is controlled by an endogenous circadian clock. The cloning and characterization of the first Drosophila clock gene period in the early 1980s, independently by Jeffery C. Hall and Michael Rosbash at Brandeis University and Michael Young at Rockefeller University, paved the way for their further discoveries of additional genes and proteins, culminating in establishing the so-called transcriptional translational feedback loop (TTFL) model for the generation of autonomous oscillator with a period of ∼24 h...
February 2018: Biomedical Journal
https://www.readbyqxmd.com/read/29673433/metabolic-syndrome-in-the-german-air-force-prevalence-and-associations-with-bmi-and-physical-fitness
#16
Frank Weber
BACKGROUND: Metabolic syndrome is a cluster of metabolic abnormalities that can affect a pilot's health. The aim of the study was to establish the prevalence of metabolic syndrome in the German Air Force. METHODS: All German military pilots are examined regularly at the German Air Force Center of Aerospace Medicine. The data are stored in a special database designed for that purpose. A database query was performed. The following parameters were analyzed: age, duration of observation, BMI, physical working capacity (PWC 170), blood pressure, erythrocyte sedimentation rate (ESR), cholesterol, HDL-cholesterol, triglycerides, fasting blood glucose...
May 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29673152/beneficial-effect-of-ocimum-sanctum-linn-against-monocrotaline-induced-pulmonary-hypertension-in-rats
#17
Himanshu Meghwani, Pankaj Prabhakar, Soheb A Mohammed, Pamila Dua, Sandeep Seth, Milind P Hote, Sanjay K Banerjee, Sudheer Arava, Ruma Ray, Subir Kumar Maulik
BACKGROUND: The study was designed to explore any beneficial effect of Ocimum sanctum (Linn) (OS) in experimental pulmonary hypertension (PH) in rats. OS is commonly known as &ldquo;holy basil&rdquo; and &ldquo;Tulsi&rdquo; and is used in the Indian System of Medicine as antidiabetic, antioxidant, hepatoprotective, adaptogenic, and cardioprotective. METHODS: Monocrotaline (MCT) administration caused development of PH in rats after 28 days and rats were observed for 42 days...
April 17, 2018: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29672600/associations-of-obesity-with-tracheal-intubation-success-on-first-attempt-and-adverse-events-in-the-emergency-department-an-analysis-of-the-multicenter-prospective-observational-study-in-japan
#18
Hiromasa Yakushiji, Tadahiro Goto, Wataru Shirasaka, Yusuke Hagiwara, Hiroko Watase, Hiroshi Okamoto, Kohei Hasegawa
Obesity is deemed to increase the risk of difficult tracheal intubation. However, there is a dearth of research that examines the relationship of obesity with intubation success and adverse events in the emergency department (ED). We analyzed the data from a prospective, observational, multicenter study-the Japanese Emergency Airway Network (JEAN) 2 study from 2012 through 2016. We included all adults (aged ≥18 years) who underwent tracheal intubation in the ED. Patients were categorized into three groups according to their body mass index (BMI): lean (<25...
2018: PloS One
https://www.readbyqxmd.com/read/29671239/ethnobotanical-knowledge-of-pastoral-community-for-treating-livestock-diseases-in-somali-regional-state-eastern-ethiopia
#19
Ewonetu Kebede, Melese Mengistu, Biresaw Serda
Modern livestock health care is still at its lowest stage in Ethiopia and most modern veterinary services like drugs and veterinary professionals are not accessible and affordable to the majority of pastoral farmers. As a result, they rely on their traditional knowledge and practices on locally available. However, this traditional knowledge has not yet been well documented. Therefore, this study identified medicinal plants used in treating animal diseases and examined factors that threatens ethno-veterinary in pastoral community of Shinle Districts...
April 18, 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29671173/cornus-mas-l-fruit-as-a-potential-source-of-natural-health-promoting-compounds-physico-chemical-characterisation-of-bioactive-components
#20
Marta De Biaggi, Dario Donno, Maria Gabriella Mellano, Isidoro Riondato, Ernest N Rakotoniaina, Gabriele L Beccaro
Interest in new sources of anti-inflammatory and antioxidant compounds has recently become a major research issue, with the cornelian cherry (Cornus mas L.) receiving particular attention for its significant amounts of phenolic compounds and vitamins, which exhibit a wide range of biological and pharmacological properties. This study was aimed at increasing knowledge regarding the cornelian cherry in Italy through the analysis of biologically active substances in the locally available genotype "Chieri"...
April 19, 2018: Plant Foods for Human Nutrition
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