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https://www.readbyqxmd.com/read/28938071/automatic-identification-and-quantification-of-extra-well-fluorescence-in-microarray-images
#1
Robert Rivera, Jie Wang, Xiaobo Yu, Gokhan Demirkan, Marika Hopper, Xiaofang Bian, Tasnia Tahsin, D Mitchell Magee, Ji Qiu, Joshua LaBaer, Garrick Wallstrom
In recent studies involving NAPPA microarrays, extra-well fluorescence is used as a key measure for identifying disease biomarkers since there is evidence to support that it is better correlated with strong antibody responses than statistical analysis involving intra-spot intensity. Since this feature is not well quantified by traditional image analysis software, identification and quantification of extra-well fluorescence is performed manually, which is both time consuming and highly susceptible to variation between raters...
September 22, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28935225/heart-rate-variability-biofeedback-and-other-psychophysiological-procedures-as-important-elements-in-psychotherapy
#2
REVIEW
Paul Lehrer
Lang's distinction of psychophysiological, behavioral, and cognitive domains in psychological problems and therapies provides a useful heuristic for guiding psychotherapy. Much psychotherapy practice emphasizes the cognitive domain, but behavioral and psychophysiological interventions show at least equivalent effectiveness for some kinds of problems. Most descriptions of cognitive behavior therapy emphasize cognitive procedures, although most CBT approaches also incorporate behavioral interventions such as social skills training, exposure, and behavior activation...
September 18, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28934272/a-multimodal-logistics-service-network-design-with-time-windows-and-environmental-concerns
#3
Dezhi Zhang, Runzhong He, Shuangyan Li, Zhongwei Wang
The design of a multimodal logistics service network with customer service time windows and environmental costs is an important and challenging issue. Accordingly, this work established a model to minimize the total cost of multimodal logistics service network design with time windows and environmental concerns. The proposed model incorporates CO2 emission costs to determine the optimal transportation mode combinations and investment selections for transfer nodes, which consider transport cost, transport time, carbon emission, and logistics service time window constraints...
2017: PloS One
https://www.readbyqxmd.com/read/28933910/ranking-low-feeling-high-how-hierarchical-position-and-experienced-power-promote-prosocial-behavior-in-response-to-procedural-justice
#4
Marius van Dijke, David De Cremer, Gerben Langendijk, Cameron Anderson
Research shows that power can lead to prosocial behavior by facilitating the behavioral expression of dispositional prosocial motivation. However, it is not clear how power may facilitate responses to contextual factors that promote prosocial motivation. Integrating fairness heuristic theory and the situated focus theory of power, we argue that in particular, organization members in lower (vs. higher) hierarchical positions who simultaneously experience a high (vs. low) sense of power respond with prosocial behavior to 1 important antecedent of prosocial motivation, that is, the enactment of procedural justice...
September 21, 2017: Journal of Applied Psychology
https://www.readbyqxmd.com/read/28932410/quantitative-characterization-of-optic-nerve-atrophy-in-patients-with-multiple-sclerosis
#5
Robert L Harrigan, Alex K Smith, Bailey Lyttle, Bailey Box, Bennett A Landman, Francesca Bagnato, Siddharama Pawate, Seth A Smith
BACKGROUND: Optic neuritis (ON) is one of the most common presentations of multiple sclerosis (MS). Magnetic resonance imaging (MRI) of the optic nerves is challenging because of retrobulbar motion, orbital fat and susceptibility artifacts from maxillary sinuses; therefore, axonal loss is investigated with the surrogate measure of a single heuristically defined point along the nerve as opposed to volumetric investigation. OBJECTIVE: The objective of this paper is to derive optic nerve volumetrics along the entire nerve length in patients with MS and healthy controls in vivo using high-resolution, clinically viable MRI...
July 2017: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/28932103/a-modified-mean-gray-wolf-optimization-approach-for-benchmark-and-biomedical-problems
#6
Narinder Singh, S B Singh
A modified variant of gray wolf optimization algorithm, namely, mean gray wolf optimization algorithm has been developed by modifying the position update (encircling behavior) equations of gray wolf optimization algorithm. The proposed variant has been tested on 23 standard benchmark well-known test functions (unimodal, multimodal, and fixed-dimension multimodal), and the performance of modified variant has been compared with particle swarm optimization and gray wolf optimization. Proposed algorithm has also been applied to the classification of 5 data sets to check feasibility of the modified variant...
2017: Evolutionary Bioinformatics Online
https://www.readbyqxmd.com/read/28931613/interacting-networks-of-brain-regions-underlie-human-spatial-navigation-a-review-and-novel-synthesis-of-the-literature
#7
Arne D Ekstrom, Derek J Huffman, Michael Starrett
Navigation is an inherently dynamic and multimodal process, making isolation of the unique cognitive components underlying it challenging. The assumptions of much of the literature on human spatial navigation are that: 1) spatial navigation involves modality independent, discrete metric representations (i.e., egocentric vs. allocentric) 2) such representations can be further distilled to elemental cognitive processes 3) these cognitive processes can be ascribed to unique brain regions. Here, we argue that modality independent spatial representations, instead of providing exact metrics about our surrounding environment, more often involve heuristics for estimating spatial topology useful to the current task at hand...
September 20, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28926585/degree-sums-and-dense-spanning-trees
#8
Tao Li, Yingqi Gao, Qiankun Dong, Hua Wang
Finding dense spanning trees (DST) in unweighted graphs is a variation of the well studied minimum spanning tree problem (MST). We utilize established mathematical properties of extremal structures with the minimum sum of distances between vertices to formulate some general conditions on the sum of vertex degrees. We analyze the performance of various combinations of these degree sum conditions in finding dense spanning subtrees and apply our approach to practical examples. After briefly describing our algorithm we also show how it can be used on variations of DST, motivated by variations of MST...
2017: PloS One
https://www.readbyqxmd.com/read/28926027/using-institutional-and-behavioural-economics-to-examine-animal-health-systems
#9
C A Wolf
Economics provides a framework for understanding management decisions and their policy implications for the animal health system. While the neoclassical economic model is useful for framing animal health decisions on the farm, some of its assumptions and prescriptive results may be unrealistic. Institutional and behavioural economics address some of these potential shortcomings by considering the role of information, psychology and social factors in decisions. Framing such decisions under contract theory allows us to consider asymmetric information between policy-makers and farmers...
April 2017: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/28924006/the-neural-basis-of-aversive-pavlovian-guidance-during-planning
#10
Níall Lally, Quentin J M Huys, Neir Eshel, Paul Faulkner, Peter Dayan, Jonathan P Roiser
Important real-world decisions are often arduous as they frequently involve sequences of choices, with initial selections affecting future options. Evaluating every possible combination of choices is computationally intractable, particularly for longer multi-step decisions. Therefore, humans frequently employ heuristics to reduce the complexity of decisions. We recently used a goal-directed planning task to demonstrate the profound behavioral influence and ubiquity of one such shortcut, namely aversive pruning, a reflexive Pavlovian process that involves neglecting parts of the decision space residing beyond salient negative outcomes...
September 18, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28922774/crop-model-assisted-phenomics-and-genome-wide-association-study-for-climate-adaptation-of-indica-rice-1-phenology
#11
Michael Dingkuhn, Richard Pasco, Julie M Pasuquin, Jean Damo, Jean-Christophe Soulié, Louis-Marie Raboin, Julie Dusserre, Abdoulaye Sow, Baboucarr Manneh, Suchit Shrestha, Alpha Balde, Tobias Kretzschmar
Phenology and time of flowering are crucial determinants of rice adaptation to climate variation. A previous study characterized flowering responses of 203 diverse indica rices (the ORYTAGE panel) to ten environments in Senegal (six sowing dates) and Madagascar (two years and two altitudes) under irrigation in the field. This study used the physiological phenology model RIDEV V2 to heuristically estimate component traits of flowering such as cardinal temperatures (base temperature (Tbase) and optimum temperature), basic vegetative phase, photoperiod sensitivity and cold acclimation, and to conduct a genome-wide association study for these traits using 16 232 anonymous single-nucleotide polymorphism (SNP) markers...
July 10, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28922648/a-theoretical-and-empirical-modeling-of-anxiety-integrated-with-rdoc-and-temporal-dynamics
#12
Brandon Frank, Nicholas C Jacobson, Landon Hurley, Dean McKay
The newly launched Research Domain Criteria (RDoC) emphasize specific mechanisms over diagnostic categories of psychopathology. In our view, RDoC provides a useful heuristic for mental health disorders, but does not capture the complexity of psychological data when proposed mechanisms are viewed as static entities. However, temporal and complex system dynamics may advance RDoC's utility. By investigating temporal patterns within trajectories and the interaction of complex networks, we propose that dynamic modeling provides comprehensive methods with which to investigate the etiopathology and maintenance of mental health disorders...
September 8, 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/28922133/aligning-event-logs-to-task-time-matrix-clinical-pathways-in-bpmn-for-variance-analysis
#13
Hui Yan, Pieter Van Gorp, Uzay Kaymak, Xudong Lu, Lei Ji, Choo Chiap Chiau, Hendriks H M Korsten, Huilong Duan
Clinical pathways (CPs) are popular healthcare management tools to standardise care and ensure quality. Analysing CP compliance levels and variances is known to be useful for training and CP redesign purposes. Flexible semantics of the Business Process Model and Notation (BPMN) language has been shown to be useful for the modeling and analysis of complex protocols. However, in practical cases one may want to exploit that CPs often have the form of Task-Time matrices. This paper presents a new method parsing complex BPMN models and aligning traces to the models heuristically...
September 18, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28921538/a-fast-inverse-treatment-planning-strategy-facilitating-optimized-catheter-selection-in-image-guided-high-dose-rate-interstitial-gynecologic-brachytherapy
#14
Christian V Guthier, Antonio L Damato, Juergen W Hesser, Akila N Viswanathan, Robert A Cormack
PURPOSE: Interstitial high-dose-rate (HDR) brachytherapy is an important therapeutic strategy for the treatment of locally advanced gynecologic (GYN) cancers. The outcome of this therapy is determined by the quality of dose distribution achieved. This paper focuses on a novel yet simple heuristic for catheter selection for GYN HDR brachytherapy and their comparison against state of the art optimization strategies. The proposed technique is intended to act as a decision-supporting tool to select a favorable needle configuration...
September 18, 2017: Medical Physics
https://www.readbyqxmd.com/read/28919539/the-nexus-between-the-documentation-of-end-of-life-wishes-and-awareness-of-dying-a-model-for-research-education-and-care
#15
Deborah P Waldrop, Jacqueline M McGinley, Brian Clemency
The convergence of medical treatment that can extend life with written medical orders that make it possible to refuse such treatment brings the differential dynamics of contemporary end-of-life decision-making into sharp focus. Communication between families and clinicians can be confusing, uncertain and pressured when death is imminent. These situations create distress that ultimately influences the end-of-life experience for people who are dying and those who care for them. This paper presents the analysis of the decisional dynamics that emerge from the intersection of the patient-family-provider awareness that death is near with the presence or absence of documentation of expressed wishes for end-of-life care...
September 14, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28919286/a-novel-optimized-hybrid-fuzzy-logic-intelligent-pid-controller-for-an-interconnected-multi-area-power-system-with-physical-constraints-and-boiler-dynamics
#16
A H Gomaa Haroun, Yin-Ya Li
In the fast developing world nowadays, load frequency control (LFC) is considered to be a most significant role for providing the power supply with good quality in the power system. To deliver a reliable power, LFC system requires highly competent and intelligent control technique. Hence, in this article, a novel hybrid fuzzy logic intelligent proportional-integral-derivative (FLiPID) controller has been proposed for LFC of interconnected multi-area power systems. A four-area interconnected thermal power system incorporated with physical constraints and boiler dynamics is considered and the adjustable parameters of the FLiPID controller are optimized using particle swarm optimization (PSO) scheme employing an integral square error (ISE) criterion...
September 14, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28918312/-reinforcement-learning-to-forage-optimally
#17
REVIEW
Nils Kolling, Thomas Akam
Foraging effectively is critical to the survival of all animals and this imperative is thought to have profoundly shaped brain evolution. Decisions made by foraging animals often approximate optimal strategies, but the learning and decision mechanisms generating these choices remain poorly understood. Recent work with laboratory foraging tasks in humans suggest their behaviour is poorly explained by model-free reinforcement learning, with simple heuristic strategies better describing behaviour in some tasks, and in others evidence of prospective prediction of the future state of the environment...
September 14, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/28916330/brains-language-and-the-argumentative-mind-in-western-and-eastern-societies-the-fertile-differences-between-western-eastern-argumentative-traditions
#18
REVIEW
Jordi Vallverdú
The philosophical differences between Western and Eastern philosophy not only derive from general cultural ideas about reality, but as Nisbet writes (2003), are also methodological, ontological, and cognitively driven. Thus, we can see that strategies of thought and theory-generation are constrained and enabled by conceptual levels, and that the existence of differences and within these levels may be pragmatically combined in fruitful ways. At this point, I remark that there is not a single way to connect biology and culture, but at least we need to admit that brains allow the existence of minds and that these create languages, which also organize the world symbolically following a long set of (sometimes interconnected) heuristics...
September 12, 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/28916011/family-based-integrated-care-fbic-in-a-partial-hospital-program-for-complex-pediatric-illness-fostering-shifts-in-family-illness-beliefs-and-relationships
#19
REVIEW
Michelle L Rickerby, Diane DerMarderosian, Jack Nassau, Christopher Houck
The heuristic model of family-based integrated care (FBIC) was developed from 1998 to 2016 in the context of the development of the Hasbro Children's Partial Hospital Program (HCPHP) along with the development of a family therapy training program for Brown University child psychiatry and triple board residents. The clinical experience of the HCPHP team in treating more than 2000 patients and families in combination with the authors' experience in training residents for diverse practice settings highlights the usefulness of the FBIC paradigm for interdisciplinary family-based treatment for a broad range of illnesses and levels of care...
October 2017: Child and Adolescent Psychiatric Clinics of North America
https://www.readbyqxmd.com/read/28912584/niche-harmony-search-algorithm-for-detecting-complex-disease-associated-high-order-snp-combinations
#20
Shouheng Tuo, Junying Zhang, Xiguo Yuan, Zongzhen He, Yajun Liu, Zhaowen Liu
Genome-wide association study is especially challenging in detecting high-order disease-causing models due to model diversity, possible low or even no marginal effect of the model, and extraordinary search and computations. In this paper, we propose a niche harmony search algorithm where joint entropy is utilized as a heuristic factor to guide the search for low or no marginal effect model, and two computationally lightweight scores are selected to evaluate and adapt to diverse of disease models. In order to obtain all possible suspected pathogenic models, niche technique merges with HS, which serves as a taboo region to avoid HS trapping into local search...
September 14, 2017: Scientific Reports
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