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Virtue

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https://www.readbyqxmd.com/read/28432631/coumarin-based-fluorescent-probe-for-hypochlorites-and-real-application-in-tap-water
#1
Xiaohong Cheng, Shaohua Qu, Zhicheng Zhong, Wangnan Li
Taking advantages of both the oxidation property of hypochlorite and different coordination properties of Cu(+) and Cu(2+) ions, we developed a new fluorescent probe for hypochlorite anion, namely, compound C1. In the presence of ClO(-), the sensing system displayed extraordinary fluorescence quenching, which was beneficial to the production of a high signal output during detection process. By virtue of its special oxidation property, the probe displayed high selectivity for ClO(-) over other anions. Moreover, this novel sensing system could be used for the analysis of ClO(-) levels in tap water and potentially in environmental samples...
April 21, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/28431604/a-reappraisal-of-diagnostic-tests-for-myasthenia-gravis-in-a-large-asian-cohort
#2
Yew Long Lo, Raymond P Najjar, Kelvin Y Teo, Sharon L Tow, Jing Liang Loo, Dan Milea
BACKGROUND: Myasthenia gravis (MG) is a chronic autoimmune neuromuscular disease characterized by weakness of bodily skeletal muscles. Office-based diagnostic tests such as repetitive nerve stimulation (RNS), single fiber electromyography (SFEMG), and the ice test, are used to refine the differential clinical diagnosis of this disease. Evaluating the clinical sensitivity and specificity of these tests, however, may be confounded by lack of a gold standard, non-blinding, incorporation bias, use of non-representative populations and retrospective data...
May 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28430938/characterization-of-yjjj-toxin-of-escherichia-coli
#3
Yuki Maeda, Chun-Yi Lin, Yojiro Ishida, Masayori Inouye, Yoshihiro Yamaguchi, Sangita Phadtare
Reminiscent of eukaryotic apoptotic programmed cell death, bacteria also contain a large number of suicide genes, which are in general co-expressed with their cognate antitoxic genes. These systems called the toxin-antitoxin (TA) systems are associated with cellular dormancy, and play major roles in biofilm formation and persistent multi-drug resistance of many human pathogens. In recent years, the study on TA system toxins has become a hot topic due to the health implications of these toxins by virtue of their role in bacterial pathogenicity...
April 19, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28430569/courage-and-compassion-virtues-in-caring-for-so-called-difficult-patients
#4
Michael Hawking, Farr A Curlin, John D Yoon
What, if anything, can medical ethics offer to assist in the care of the "difficult" patient? We begin with a discussion of virtue theory and its application to medical ethics. We conceptualize the "difficult" patient as an example of a "moral stress test" that especially challenges the physician's character, requiring the good physician to display the virtues of courage and compassion. We then consider two clinical vignettes to flesh out how these virtues might come into play in the care of "difficult" patients, and we conclude with a brief proposal for how medical educators might cultivate these essential character traits in physicians-in-training...
April 1, 2017: AMA Journal of Ethics
https://www.readbyqxmd.com/read/28429302/ethics-guidelines-in-environmental-epidemiology-their-development-and-challenges-we-face
#5
REVIEW
Shira Kramer, Colin L Soskolne
PURPOSE OF REVIEW: This review integrates historical developments and key events in bringing ethics into epidemiology in general and into environmental epidemiology in particular. The goal is to provide context for and discern among the various approaches and motivations that drive the need for ethical conduct in support of the public interest. RECENT FINDINGS: The need for ethics guidelines in epidemiology is different from developments in other biomedical-related fields by virtue of its focus on populations rather than on individuals...
April 20, 2017: Current Environmental Health Reports
https://www.readbyqxmd.com/read/28425740/-healthier-than-thou-practicing-what-you-preach-backfires-by-increasing-anticipated-devaluation-correction-to-howe-and-monin-2017
#6
(no author information available yet)
Reports an error in "Healthier Than Thou? "Practicing What You Preach" Backfires by Increasing Anticipated Devaluation" by Lauren C. Howe and Benoît Monin (Journal of Personality and Social Psychology, Advanced Online Publication, Feb 27, 2017, np). In the article, the beginning phrase of the second paragraph of the Internal Meta-Analysis of Studies 3 Through 5 section is incorrect. It should instead begin as follows: Across the three studies. The Monin et al. (2014) reference in both the References list and in text is included in error...
May 2017: Journal of Personality and Social Psychology
https://www.readbyqxmd.com/read/28424973/pcsk9-inhibitors-in-hyperlipidemia-current-status-and-clinical-outlook
#7
Belinda Di Bartolo, Daniel J Scherer, Alex Brown, Peter J Psaltis, Stephen J Nicholls
The clinical reality of residual risk despite statin (HMG-CoA reductase inhibitor) therapy and emergence of statin intolerance support the need to develop additional lipid-lowering strategies. Proprotein convertase subtilisin kexin type 9 (PCSK9) has received considerable attention by virtue of genetic and clinical studies that have revealed its pivotal role in the regulation of cholesterol homeostasis. Monoclonal antibodies have been developed targeting PCSK9, which have been demonstrated to produce profound low-density lipoprotein cholesterol (LDL-C) lowering when provided as monotherapy or in combination with statins...
April 19, 2017: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://www.readbyqxmd.com/read/28422501/interfacial-activity-of-non-amphiphilic-particles-in-fluid-fluid-interfaces
#8
Yi Zhang, Songcheng Wang, Jiarun Zhou, Ruiyang Zhao, Gregory Benz, Stephane Tcheimou, J Carson Meredith, Sven Holger Behrens
Surfactants can adsorb in fluid-fluid interfaces and lower the interfacial tension. Like surfactants, particles with appropriate wettability can also adsorb in fluid-fluid interfaces. Despite many studies of particle adsorption at fluid interfaces, some confusion persists regarding the ability of (simple, non-amphiphilic) particles to reduce the interfacial tension. In the present work, the interfacial activity of silica nanoparticles at air-water and hexadecane-water interfaces and of ethyl cellulose particles at the interface of water with trimethylolpropane trimethacrylate was analyzed through pendant drop tensiometry...
April 19, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28421865/it-s-not-all-about-moral-reasoning-understanding-the-content-of-moral-case-deliberation
#9
Mia Svantesson, Marit Silén, Inger James
BACKGROUND: Moral Case Deliberation is one form of clinical ethics support described as a facilitator-led collective moral reasoning by healthcare professionals on a concrete moral question connected to their practice. Evaluation research is needed, but, as human interaction is difficult to standardise, there is a need to capture the content beyond moral reasoning. This allows for a better understanding of Moral Case Deliberation, which may contribute to further development of valid outcome criteria and stimulate the normative discussion of what Moral Case Deliberation should contain...
January 1, 2017: Nursing Ethics
https://www.readbyqxmd.com/read/28421813/hemin-causes-lung-microvascular-endothelial-barrier-dysfunction-by-necroptotic-cell-death
#10
Sunit Singla, Justin R Sysol, Benjamin Dille, Nicole Jones, Jiwang Chen, Roberto F Machado
Hemin, the oxidized prosthetic moiety of hemoglobin, has been implicated in the pathogenesis of acute chest syndrome (ACS) in sickle cell patients by virtue of its endothelial-activating properties. In this study, we examined whether hemin can cause lung microvascular endothelial barrier dysfunction. By assessing transendothelial resistance using electrical cell impedance sensing, and by directly measuring trans-monolayer FITC-dextran flux, we found that hemin does cause endothelial barrier dysfunction in a concentration-dependent manner...
April 19, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28420233/novel-hydrogen-bonding-crosslinking-aggregation-induced-emission-water-as-a-fluorescent-ribbon-detected-in-a-wide-range
#11
Ani Wang, Ruiqing Fan, Yuwei Dong, Yang Song, Yuze Zhou, Jianzong Zheng, Xi Du, Kai Xing, Yulin Yang
The development of efficient sensors for detection of the water content in a wide detection range is highly desirable for balance many industrial processes and products. Presented herein are six novel different substituted of Schiff base Zn(II) complexes, which exhibit the remarkable capability to detect traces of water in wide linear range (the most can reach to 0-94%, v/v), low detection limit of 0.2% (v/v) and rapidly response time of 8s in various organic solvents by virtue of an unusual water-activated hydrogen-bonding crosslinking AIE (WHCAIE) mechanism...
April 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28415746/epigenetic-up-regulation-of-ribosome-biogenesis-and-more-aggressive-phenotype-triggered-by-the-lack-of-the-histone-demethylase-jhdm1b-in-mammary-epithelial-cells
#12
Alice Galbiati, Marianna Penzo, Maria Giulia Bacalini, Carmine Onofrillo, Ania Naila Guerrieri, Paolo Garagnani, Claudio Franceschi, Davide Treré, Lorenzo Montanaro
The alterations of ribosome biogenesis and protein synthesis play a direct role in the development of tumors. The accessibility and transcription of ribosomal genes is controlled at several levels, with their epigenetic regulation being one of the most important. Here we explored the JmjC domain-containing histone demethylase 1B (JHDM1B) function in the epigenetic control of rDNA transcription. Since JHDM1B is a negative regulator of gene transcription, we focused on the effects induced by JHDM1B knock-down (KD)...
March 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415267/dispersion-relation-for-electromagnetic-propagation-in-stochastic-dielectric-and-magnetic-helical-photonic-crystals
#13
Carlos G Avendaño, Arturo Reyes
We theoretically study the dispersion relation for axially propagating electromagnetic waves throughout a one-dimensional helical structure whose pitch and dielectric and magnetic properties are spatial random functions with specific statistical characteristics. In the system of coordinates rotating with the helix, by using a matrix formalism, we write the set of differential equations that governs the expected value of the electromagnetic field amplitudes and we obtain the corresponding dispersion relation...
March 2017: Physical Review. E
https://www.readbyqxmd.com/read/28414143/the-use-of-hemoglobin-vesicles-for-delivering-medicinal-gas-for-the-treatment-of-intractable-disorders
#14
REVIEW
Kazuaki Taguchi, Keishi Yamasaki, Hiromi Sakai, Toru Maruyama, Masaki Otagiri
Bioactive gaseous molecules, such as oxygen (O2) and carbon monoxide (CO), are essential elements for most living organisms to maintain their homeostasis and biological activities. An accumulating body of evidence suggests that such molecules can be used in clinics as a medical gas in the treatment of various intractable disorders. Recent developments in hemoglobin-encapsulated liposomes, namely, Hemoglobin-vesicles (HbV), possess great potential for retaining O2 and CO, and could lead to strategies for the development of novel pharmacological agents as medical gas donors...
April 13, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28412170/lipid-nanoparticle-systems-for-enabling-gene-therapies
#15
REVIEW
Pieter R Cullis, Michael J Hope
Genetic drugs such as small interfering RNA (siRNA), mRNA, or plasmid DNA provide potential gene therapies to treat most diseases by silencing pathological genes, expressing therapeutic proteins, or through gene-editing applications. In order for genetic drugs to be used clinically, however, sophisticated delivery systems are required. Lipid nanoparticle (LNP) systems are currently the lead non-viral delivery systems for enabling the clinical potential of genetic drugs. Application will be made to the Food and Drug Administration (FDA) in 2017 for approval of an LNP siRNA drug to treat transthyretin-induced amyloidosis, presently an untreatable disease...
April 13, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28411807/a-sensitive-and-disposable-indium-tin-oxide-based-electrochemical-immunosensor-for-label-free-detection-of-mage-1
#16
Burçak Demirbakan, Mustafa Kemal Sezgintürk
MAGE-1 (MAGE, for melanoma antigen), was identified by virtue of its processing and cell surface expression as a tumor-specific peptide bound to major histocompatibility complexes which was reactive with autolytic T cells. 3-Glycidoxypropyltrimethoxysilane (3-GOPS) is frequently employed for the preparation of dense heterometal hybrid polymers which are used, e.g., for hard coatings of organic polymers and contact lens materials in the optical industry. In this study, we have improved a new immunological biosensor with indium tin oxide (ITO)...
July 1, 2017: Talanta
https://www.readbyqxmd.com/read/28411533/label-free-upconversion-nanoparticles-based-fluorescent-probes-for-sequential-sensing-of-cu-2-pyrophosphate-and-alkaline-phosphatase-activity
#17
Fangfang Wang, Cuiling Zhang, Qin Xue, Huaping Li, Yuezhong Xian
An efficient near-infrared fluorescence probe has been developed for the sequential detection of Cu(2+), pyrophosphate (P2O7(4-), PPi), and alkaline phosphatase (ALP), which is based on the "off-on-off" fluorescence switch of branched polyethyleneimine (PEI)-capped NaGdF4:Yb/Tm upconversion nanoparticles (UCNPs). The fluorescence is quenched via energy transfer from UCNPs to Cu(2+) for the coordination of PEI with Cu(2+). The strong affinity between Cu(2+) and PPi leads to the formation of Cu(2+)-PPi complex and results in the detachment of Cu(2+) from the surface of UCNPs, thus the fluorescence is triggered on...
April 12, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28409828/leucine-elicits-myotube-hypertrophy-and-enhances-maximal-contractile-force-in-tissue-engineered-skeletal-muscle-in-vitro
#18
N R W Martin, M C Turner, R Farrington, D J Player, M P Lewis
The amino acid leucine is thought to be important for skeletal muscle growth by virtue of its ability to acutely activate mTORC1 and enhance muscle protein synthesis, yet little data exist regarding its impact on skeletal muscle size and its ability to produce force. We utilised a tissue engineering approach in order to test whether supplementing culture medium with leucine could enhance mTORC1 signalling, myotube growth and muscle function. Phosphorylation of the mTORC1 target proteins 4EBP-1 and rpS6 and myotube hypertrophy appeared to occur in a dose dependent manner, with 5 and 20mM of leucine inducing similar effects, which were greater than those seen with 1mM...
April 14, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28409461/determination-of-peroxisomal-ph-in-living-mammalian-cells-using-phred
#19
Luis F Godinho, Michael Schrader
Organelle pH homeostasis is crucial for maintaining proper cellular function. The nature of the peroxisomal pH remains somewhat controversial, with several studies reporting conflicting results. Here, we describe in detail a rapid and accurate method for the measurement of peroxisomal pH, using the pHRed sensor protein and confocal microscopy of living mammalian cells. pHRed, a ratiometric sensor of pH, is targeted to the peroxisomes by virtue of a C-terminal targeting sequence. The probe has a maximum fluorescence emission at 610 nm while exhibiting dual excitation peaks at 440 and 585 nm, allowing for ratiometric imaging and determination of intracellular pH in live cell microscopy...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28404842/an-immortalized-human-dorsal-root-ganglia-cell-line-provides-a-novel-context-to-study-herpes-simplex-virus-type-1-latency-and-reactivation
#20
Nikki M Thellman, Carolyn Botting, Zachary Madaj, Steven J Triezenberg
A defining characteristic of alphaherpesviruses is the establishment of lifelong latency in host sensory ganglia with occasional reactivation causing recurrent lytic infections. As an alternative to rodent models, we explored the use of an immortalized cell line derived from human dorsal root ganglia. HD10.6 cells proliferate by virtue of a transduced tetracycline-regulated v-myc oncogene. In the presence of doxycycline, HD10.6 cells mature to exhibit neuronal morphology and express sensory neuron-associated markers such as neurotrophin receptors TrkA, TrkB, TrkC, and RET and the sensory neurofilament peripherin...
April 12, 2017: Journal of Virology
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