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Mythily Srinivasan, Baindu Bayon, Nipun Chopra, Debomoy K Lahiri
In the central nervous system (CNS), activation of the transcription factor nuclear factor-kappa B (NF-κβ) is associated with both neuronal survival and increased vulnerability to apoptosis. The mechanisms underlying these dichotomous effects are attributed to the composition of NF-κΒ dimers. In Alzheimer's disease (AD), β-amyloid (Aβ) and other aggregates upregulate activation of p65:p50 dimers in CNS cells and enhance transactivation of pathological mediators that cause neuroinflammation and neurodegeneration...
2016: PloS One
Marta Macedo
In the early 1900s, an obscure Portuguese colony in the equatorial Atlantic rose as the world's leading cocoa producer. Cocoa from the island of São Tomé was grown on large plantations with indentured labor and high technological inputs. This technoscientific system, to control both plants and people, became the model for making an industry-suited cocoa, and the material evidence of the moral and economic virtues of the colonial plantation. Experts played a crucial role in building and putting into circulation such a system...
2016: Technology and Culture
Fan Zhang, Yue Sun, Demei Tian, Weon Sup Shin, Jong Seung Kim, Haibing Li
Host-guest recognition plays an important role in biological analysis and biosensing. Accordingly, great efforts have been devoted to the development of sensors using versatile 3D surface materials. These functionalized nanomaterials possess the advantages of high selectivity and visual signals, enabling the selective detection of ions, amino acids, proteins, and other biological molecules. Therefore, in this feature article, we present some significant and representative examples of molecular recognition on calixarene functionalized 3D surface nanomaterials...
October 20, 2016: Chemical Communications: Chem Comm
Michael A Woodley Of Menie, Joseph A Schwartz, Kevin M Beaver
Utilizing a newly released cognitive Polygenic Score (PGS) from Wave IV of Add Health (n = 1,886), structural equation models (SEMs) examining the relationship between PGS and fertility (which is approximately 50% complete in the present sample), employing measures of verbal IQ and educational attainment as potential mediators, were estimated. The results of indirect pathway models revealed that verbal IQ mediates the positive relationship between PGS and educational attainment, and educational attainment in turn mediates the negative relationship between verbal IQ and a latent fertility measure...
October 20, 2016: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
Fiorella Casamenti, Massimo Stefani
Clinical trials and population studies indicate the healthy virtues of the Mediterranean diet and its main lipid component, extra-virgin olive oil (EVOO). Olive leaves and EVOO contain many phenolics effective against several aging and lifestyle-related diseases, including neurodegeneration, both in animal models and in humans. Recent research has shown that such protection stems from several effects, including (i.) the interference with the aggregation of peptides/proteins found in amyloid diseases, particularly in Alzheimer's and Parkinson's diseases; (ii...
October 20, 2016: Expert Review of Neurotherapeutics
Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Masashi Tachibana, Toshiyoshi Fujiwara, Hiroyuki Mizuguchi
Oncolytic viruses have been receiving much attention as potential agents for cancer treatment. Among the various types of oncolytic viruses, the telomerase-specific replication-competent adenovirus (TRAD), which carries the tumor-specific promoter-driven E1 gene expression cassette, exhibits efficient antitumor effects. The development of a novel TRAD that shows higher replication efficiency and antitumor activity would be highly beneficial for safer and more efficient cancer therapy. We recently demonstrated that the endoribonuclease Dicer significantly inhibits the replication of wild-type adenovirus (Ad) via the processing of viral-associated (VA)-RNAs, which are Ad-encoded small noncoding RNAs, and that the knockdown of Dicer leads to enhanced VA-RNA expression and Ad replication after infection with wild-type Ad...
October 19, 2016: Molecular Cancer Therapeutics
B Turner
BACKGROUND: The Central Statistics Office released new figures on Ireland's health spending in December 2015, based on the System of Health Accounts (SHA2011). These figures differ from previous figures, by virtue of an expanded definition of what constitutes health care. The new figures also provide more detail on health expenditure than the previous figures allowed. AIMS: This article examines the new figures, drawing out findings of note and discussing the implications of these for the Irish health care system...
October 18, 2016: Irish Journal of Medical Science
Brian D Gonzalez, Sharon L Manne, Jerod Stapleton, Shannon Myers-Virtue, Melissa Ozga, David Kissane, Carolyn Heckman, Mark Morgan
PURPOSE: The course of quality of life after diagnosis of gynecologic cancer is not well understood. We aimed to identify subgroups of gynecologic cancer patients with distinct trajectories of quality of life outcomes in the 18-month period after diagnosis. We also aimed to determine whether these subgroups could be distinguished by predictors derived from Social-Cognitive Processing Theory. METHODS: Gynecologic cancer patients randomized to usual care as part of a psychological intervention trial (NCT01951807) reported on depressed mood, quality of life, and physical impairment soon after diagnosis and at five additional assessments ending 18 months after baseline...
October 19, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Rahul Pal, Saif Hameed, Sharda Sharma, Zeeshan Fatima
Novel strategies to combat the ever increasing burden of drug resistance in Mycobacterium tuberculosis (MTB) causing tuberculosis (TB) remains a global concern. The ability of MTB to sense and adapt to restricted iron conditions in the hostile environment is essential for their survival and confers the basis of their success as dreadful pathogen. The striking and clinically relevant virulence trait of MTB is its ability to form biofilms and adhere to the host cells. The present study elucidated the effect of iron deprivation on biofilm formation and cell adherence of Mycobacterium smegmatis, a non-pathogenic surrogate of MTB...
October 15, 2016: Brazilian Journal of Infectious Diseases
Guang-Yao Zhang, Yu-Hong Zhuang, Dan Shan, Guo-Fang Su, Serge Cosnier, Xueji Zhang
A simple and rapid photoelectrochemical (PEC) sensor is developed for the label-free detection of a phosphoprotein (α-casein) based on a zirconium based porphyrinic metal-organic framework (MOF), PCN-222, which exhibits an enhanced photocurrent response towards dopamine under the O2-saturated aqueous media. In this work, in terms of PEC measurements and cyclic voltammetry, the PEC behaviors of PCN-222 in aqueous media were thoroughly investigated for the first time. Additionally, in the virtue of the steric hindrance effect from the coordination of the phosphate groups and inorganic Zr-O clusters as binding sites in PCN-222, this biosensor shows high sensitivity for detecting α-casein and the limit of detection (LOD) is estimated to be 0...
October 18, 2016: Analytical Chemistry
Angie M Johnston, Samuel G B Johnson, Marissa L Koven, Frank C Keil
Like scientists, children seek ways to explain causal systems in the world. But are children scientists in the strict Bayesian tradition of maximizing posterior probability? Or do they attend to other explanatory considerations, as laypeople and scientists - such as Einstein - do? Four experiments support the latter possibility. In particular, we demonstrate in four experiments that 4- to 8-year-old children, like adults, have a robust latent scope bias that leads to inferences that do not maximize posterior probability...
October 17, 2016: Developmental Science
Philip Kitcher
Wisdom is a special kind of virtue. It is not to be identified with any outstanding cognitive ability-like having a prodigious memory or knowing a lot. Rather it consists in seeing what is most important and most valuable, either within a particular domain or in life as a whole. In the life of a wise person, that insight should be accompanied by traits of character, enabling the person to pursue what is seen as valuable. Viewing wisdom as a capacity for synthetic understanding, I argue for the need for philosophy, even at a time when all of us have much to learn from the sciences...
October 17, 2016: Annals of the New York Academy of Sciences
Nicola Rossi, Floris R Braakman, Davide Cadeddu, Denis Vasyukov, Gözde Tütüncüoglu, Anna Fontcuberta I Morral, Martino Poggio
Self-assembled nanowire (NW) crystals can be grown into nearly defect-free nanomechanical resonators with exceptional properties, including small motional mass, high resonant frequency and low dissipation. Furthermore, by virtue of slight asymmetries in geometry, a NW's flexural modes are split into doublets oscillating along orthogonal axes. These characteristics make bottom-up grown NWs extremely sensitive vectorial force sensors. Here, taking advantage of its adaptability as a scanning probe, we use a single NW to image a sample surface...
October 17, 2016: Nature Nanotechnology
Alistair Wardrope, Markus Reuber
Most work addressing clinical workers' professional responsibilities concerns the norms of conduct within established professional-patient relationships, but such responsibilities may extend beyond the clinical context. We explore health workers' professional responsibilities in such "informal" encounters through the example of a doctor witnessing the misdiagnosis and mistreatment of a serious long-term condition in a television documentary, arguing that neither internalist approaches to professional responsibility (such as virtue ethics or care ethics) nor externalist ones (such as the "social contract" model) provide sufficiently clear guidance in such situations...
November 2016: American Journal of Bioethics: AJOB
Akshansh Gupta, Dhirendra Kumar
A brain computer interface (BCI) is a communication system by which a person can send messages or requests for basic necessities without using peripheral nerves and muscles. Response to mental task-based BCI is one of the privileged areas of investigation. Electroencephalography (EEG) signals are used to represent the brain activities in the BCI domain. For any mental task classification model, the performance of the learning model depends on the extraction of features from EEG signal. In literature, wavelet transform and empirical mode decomposition are two popular feature extraction methods used to analyze a signal having non-linear and non-stationary property...
September 3, 2016: Brain Informatics
Virtu Solano-Collado, Mário Hüttener, Manuel Espinosa, Antonio Juárez, Alicia Bravo
Global regulators play an essential role in the adaptation of bacterial cells to specific niches. Bacterial pathogens thriving in the tissues and organs of their eukaryotic hosts are a well-studied example. Some of the proteins that recognize local DNA structures rather than specific nucleotide sequences act as global modulators in many bacteria, both Gram-negative and -positive. To this class of regulators belong the H-NS-like proteins, mainly identified in γ-Proteobacteria, and the MgaSpn-like proteins identified in Firmicutes...
2016: Frontiers in Molecular Biosciences
Susana Galli, Arlene Naranjo, Collin Van Ryn, Jason U Tilan, Emily Trinh, Chao Yang, Jessica Tsuei, Sung-Hyeok Hong, Hongkun Wang, Ewa Izycka-Swieszewska, Yi-Chien Lee, Olga C Rodriguez, Chris Albanese, Joanna Kitlinska
Neuroblastoma (NB) is a pediatric malignant neoplasm of sympathoadrenal origin. Challenges in its management include stratification of this heterogeneous disease and a lack of both adequate treatments for high-risk patients and noninvasive biomarkers of disease progression. Our previous studies have identified neuropeptide Y (NPY), a sympathetic neurotransmitter expressed in NB, as a potential therapeutic target for these tumors by virtue of its Y5 receptor (Y5R)-mediated chemoresistance and Y2 receptor (Y2R)-mediated proliferative and angiogenic activities...
October 11, 2016: American Journal of Pathology
Harald H Sitte, Christian Pifl, Ali H Rajput, Heide Hörtnagl, Junchao Tong, George K Lloyd, Stephen J Kish, Oleh Hornykiewicz
In the human brain, the claustrum is a small subcortical telencephalic nucleus, situated between the insular cortex and the putamen. A plethora of neuroanatomical studies have shown the existence of dense, widespread, bidirectional and bilateral monosynaptic interconnections between the claustrum and most cortical areas. A rapidly growing body of experimental evidence points to the integrative role of claustrum in complex brain functions, from motor to cognitive. Here, we examined for the first time, the behaviour of the classical monoamine neurotransmitters dopamine, noradrenaline and serotonin in the claustrum of the normal autopsied human brain and of patients who died with idiopathic Parkinson's disease (PD)...
October 14, 2016: European Journal of Neuroscience
Trevor A Graham, Andrea Sottoriva
The temporal dynamics of cancer evolution remain elusive because it is impractical to longitudinally observe cancers unperturbed by treatment. Consequently, our knowledge of how cancers grow largely derives from inferences made from a single point in time - the end point in the cancer's evolution when it is removed from the body and studied in the lab. Fortuitously however, the cancer genome, by virtue of on-going mutations that uniquely mark clonal lineages within the tumour, provides a rich yet surreptitious record of cancer development...
October 14, 2016: Journal of Pathology
Ying You, Quanwei Song, Le Wang, Caixia Niu, Na Na, Jin Ouyang
Plasmon-enhanced fluorescence (PEF)-based anisotropic nanostructures are considered extremely promising tools for improving the inherent problems of traditional fluorophores and for detecting important biomolecules with high sensitivity. Herein, a novel triangular gold nanoprism (AuNPR)-based fluorescence probe, AuNPR@SiO2@12,17-tetramethyl-3-dihydro-(2s-trans)-thyl-7(Ce6), was developed for PEF by virtue of multiple "hot spots" of AuNPRs. Fluorescence enhancement of fluorophores can be realized owing to the larger and stronger electromagnetic fields located at the sharp tips of AuNPRs than those on spherical particles and nanorods...
October 14, 2016: Nanoscale
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