keyword
MENU ▼
Read by QxMD icon Read
search

Virtue

keyword
https://www.readbyqxmd.com/read/28214842/inhibition-of-methylglyoxal-induced-ages-rage-expression-contributes-to-dermal-protection-by-n-acetyl-l-cysteine
#1
Chun-Tao Yang, Fu-Hui Meng, Li Chen, Xiang Li, Lai-Jian Cen, Yu-Hua Wen, Hui Zhang, Cai-Chen Li
BACKGROUND/AIM: Accumulation of advanced glycation end products (AGEs) is a major cause of diabetes mellitus (DM) skin complications. Methylglyoxal (MGO), a reactive dicarbonyl compound, is a crucial intermediate of AGEs generation. N-acetyl-L-cysteine (NAC), an active ingredient of some medicines, can induce endogenous GSH and hydrogen sulfide generation, and set off a condensation reaction with MGO. However, there is rare evidence to show NAC can alleviate DM-induced skin injury through inhibition of AGEs generation or toxicity...
February 13, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28213264/a-novel-electrochemical-biosensor-based-on-polyadenine-modified-aptamer-for-label-free-and-ultrasensitive-detection-of-human-breast-cancer-cells
#2
Kun Wang, Meng-Qi He, Fu-Heng Zhai, Rong-Huan He, Yong-Liang Yu
Simple, rapid, sensitive, and specific detection of cancer cells plays a pivotal role in the diagnosis and prognosis of cancer. A sandwich electrochemical biosensor was developed based on polyadenine (polydA)-aptamer modified gold electrode (GE) and polydA-aptamer functionalized gold nanoparticles/graphene oxide (AuNPs/GO) hybrid for the label-free and selective detection of breast cancer cells (MCF-7) via a differential pulse voltammetry (DPV) technique. Due to the intrinsic affinity between multiple consecutive adenines of polydA sequences and gold, polydA modified aptamer instead of thiol terminated aptamer was immobilized on the surface of GE and AuNPs/GO...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28208718/on-line-screening-isolation-and-identification-of-antioxidant-compounds-of-helianthemum-ruficomum
#3
Yasmine Chemam, Samir Benayache, Eric Marchioni, Minjie Zhao, Paul Mosset, Fadila Benayache
Many Helianthemum species (Cistaceae) are recognized for their various medicinal virtues. Helianthemum ruficomum is an endemic species to the septentrional Sahara on which no report is available so far. The purpose of this work was to investigate the chemical composition and the radical scavenging capacity of this species and its isolated components. Collected from Mougheul (south-west of Algeria), the aerial parts were macerated with 80% EtOH/H₂O, after evaporation, the remaining extract was diluted with H₂O and extracted with petroleum ether, chloroform, ethyl acetate and n-butanol...
February 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28208094/a-simple-strategy-to-refine-cu2o-photocatalytic-capacity-for-refractory-pollutants-removal-roles-of-oxygen-reduction-and-fe-ii-chemistry
#4
Ai-Yong Zhang, Yuan-Yi He, Tan Lin, Nai-Hui Huang, Qiao Xu, Jing-Wei Feng
Visible-light-driven photocatalysis is a promising technology for advanced water treatment, but it usually exhibits a low efficiency. Cu2O is a low-cost semiconductor with narrow band gap, high absorption coefficient and suitable conduction band, but suffers from low charge mobility, poor quantum yield and weak catalytic performance. Herein, the Cu2O catalytic capacity for refractory pollutants degradation is drastically improved by a simple and effective strategy. By virtue of the synergistic effects between photocatalysis and Fenton, a novel and efficient photocatalysis-driven Fenton system, PFC, is originally proposed and experimentally validated using Cu2O/Nano-C hybrids...
January 29, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28202683/adult-exposure-to-ocean-acidification-is-maladaptive-for-larvae-of-the-sydney-rock-oyster-saccostrea-glomerata-in-the-presence-of-multiple-stressors
#5
Laura M Parker, Wayne A O'Connor, Maria Byrne, Ross A Coleman, Patti Virtue, Michael Dove, Mitchell Gibbs, Lorraine Spohr, Elliot Scanes, Pauline M Ross
Parental effects passed from adults to their offspring have been identified as a source of rapid acclimation that may allow marine populations to persist as our surface oceans continue to decrease in pH. Little is known, however, whether parental effects are beneficial for offspring in the presence of multiple stressors. We exposed adults of the oyster Saccostrea glomerata to elevated CO2 and examined the impacts of elevated CO2 (control = 392; 856 µatm) combined with elevated temperature (control = 24; 28°C), reduced salinity (control = 35; 25) and reduced food concentration (control = full; half diet) on their larvae...
February 2017: Biology Letters
https://www.readbyqxmd.com/read/28199767/alkaliphilic-bacillus-species-show-potential-application-in-concrete-crack-repair-by-virtue-of-rapid-spore-production-and-germination-then-extracellular-calcite-formation
#6
T K Sharma, M Alazhari, A Heath, K Paine, R M Cooper
AIMS: Characterisation of alkaliphilic Bacillus species for spore production and germination and calcite formation as a prelude to investigate their potential in micro-crack remediation in concrete. METHODS AND RESULTS: Conditions, extent and timing of endospore production was determined by dark field light microscopy; germination induction and kinetics was assessed by combining reduction in optical density with formation of refractile bodies by phase contrast microscopy...
February 15, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28197067/naso-temporal-asymmetries-suppression-of-emotional-faces-in-the-temporal-visual-hemifield
#7
David Framorando, Mylène Bapst, Nathalie Vuille, Alan J Pegna
An ongoing debate exists regarding the possible existence of a retino-tectal visual pathway projecting to the amygdala, which would rapidly process information involving threatening or behaviorally-relevant stimuli. It has been suggested that this route might be responsible for the involuntary capture of attention by potentially dangerous stimuli. In separate studies, anatomical evidence has suggested that the retino-tectal pathway relies essentially on projections from the nasal hemiretina (temporal visual field)...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28195691/the-gcamp-r-family-of-genetically-encoded-ratiometric-calcium-indicators
#8
Jung-Hwa Cho, Carter J Swanson, Jeannie Chen, Ang Li, Lisa G Lippert, Shannon E Boye, Kasey Rose, Sivaraj Sivaramakrishnan, Cheng-Ming Chuong, Robert H Chow
We report on GCaMP-Rs, a new family of genetically encoded ratiometric calcium indicators that extend the virtues of the GCaMP proteins to ratiometric measurements. We have engineered a tandem construct of calcium-dependent GCaMP and calcium-independent mCherry fluorescent proteins. The tandem design assures that the two proteins localize in the same cellular compartment(s) and facilitates pixelwise ratiometric measurements; however, Förster resonance energy transfer (FRET) between the fluorophores reduces brightness of the sensor by up to half (depending on the GCaMP variant)...
February 14, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28195201/crispr-cas9-mediated-genome-editing-in-wild-derived-mice-generation-of-tamed-wild-derived-strains-by-mutation-of-the-a-nonagouti-gene
#9
Michiko Hirose, Ayumi Hasegawa, Keiji Mochida, Shogo Matoba, Yuki Hatanaka, Kimiko Inoue, Tatsuhiko Goto, Hideki Kaneda, Ikuko Yamada, Tamio Furuse, Kuniya Abe, Yoshihisa Uenoyama, Hiroko Tsukamura, Shigeharu Wakana, Arata Honda, Atsuo Ogura
Wild-derived mice have contributed to experimental mouse genetics by virtue of their genetic diversity, which may help increase the chance of identifying novel modifier genes responsible for specific phenotypes and diseases. However, gene targeting using wild-derived mice has been unsuccessful because of the unavailability of stable embryonic stem cells. Here, we report that CRISPR/Cas9-mediated gene targeting can be applied to the Japanese wild-derived MSM/Ms strain (Mus musculus molossinus). We targeted the nonagouti (a) gene encoding the agouti protein that is localized in hair and the brain...
February 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28195029/the-problem-of-epistemic-jurisdiction-in-global-governance-the-case-of-sustainability-standards-for-biofuels
#10
David E Winickoff, Matthieu Mondou
While there is ample scholarly work on regulatory science within the state, or single-sited global institutions, there is less on its operation within complex modes of global governance that are decentered, overlapping, multi-sectorial and multi-leveled. Using a co-productionist framework, this study identifies 'epistemic jurisdiction' - the power to produce or warrant technical knowledge for a given political community, topical arena or geographical territory - as a central problem for regulatory science in complex governance...
February 2017: Social Studies of Science
https://www.readbyqxmd.com/read/28193378/image-sharing-in-radiology-a-primer
#11
REVIEW
Arindam R Chatterjee, Seth Stalcup, Arjun Sharma, T Shawn Sato, Pushpender Gupta, Yueh Z Lee, Christopher Malone, Morgan McBee, Elise L Hotaling, Akash P Kansagra
By virtue of its information technology-oriented infrastructure, the specialty of radiology is uniquely positioned to be at the forefront of efforts to promote data sharing across the healthcare enterprise, including particularly image sharing. The potential benefits of image sharing for clinical, research, and educational applications in radiology are immense. In this work, our group-the Association of University Radiologists (AUR) Radiology Research Alliance Task Force on Image Sharing-reviews the benefits of implementing image sharing capability, introduces current image sharing platforms and details their unique requirements, and presents emerging platforms that may see greater adoption in the future...
March 2017: Academic Radiology
https://www.readbyqxmd.com/read/28193177/anopheline-salivary-protein-genes-and-gene-families-an-evolutionary-overview-after-the-whole-genome-sequence-of-sixteen-anopheles-species
#12
Bruno Arcà, Fabrizio Lombardo, Claudio J Struchiner, José M C Ribeiro
BACKGROUND: Mosquito saliva is a complex cocktail whose pharmacological properties play an essential role in blood feeding by counteracting host physiological response to tissue injury. Moreover, vector borne pathogens are transmitted to vertebrates and exposed to their immune system in the context of mosquito saliva which, in virtue of its immunomodulatory properties, can modify the local environment at the feeding site and eventually affect pathogen transmission. In addition, the host antibody response to salivary proteins may be used to assess human exposure to mosquito vectors...
February 13, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28188655/metal-organic-framework-derived-carbons-applications-as-solid-base-catalyst-and-support-for-pd-nanoparticles-in-tandem-catalysis
#13
Xinle Li, Biying Zhang, Yuhui Fang, Weijun Sun, Zhiyuan Qi, Yuchen Pei, Shuyan Qi, Pengyu Yuan, Xuechen Luan, Tian-Wei Goh, Wenyu Huang
The facile pyrolysis of a bipyridyl metal-organic framework, MOF-253, produces N-doped porous carbons (Cz-MOF-253), which exhibit excellent catalytic activity in the Knoevenagel condensation reaction and outperform other nitrogen-containing MOF-derived carbons. More importantly, by virtue of their high Lewis basicity and porous nature, Cz-MOF-253 supported Pd NPs (Pd/Cz-MOF-253-800) show excellent performance in a one-pot sequential Knoevenagel condensation-hydrogenation reaction.
February 11, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28188245/roquin-paralogs-differentially-regulate-functional-nkt-cell-subsets
#14
Christoph Drees, J Christoph Vahl, Sabrina Bortoluzzi, Klaus D Heger, Julius C Fischer, F Thomas Wunderlich, Christian Peschel, Marc Schmidt-Supprian
NKT cells represent a small subset of glycolipid-recognizing T cells that are heavily implicated in human allergic, autoimmune, and malignant diseases. In the thymus, precursor cells recognize self-glycolipids by virtue of their semi-invariant TCR, which triggers NKT cell lineage commitment and maturation. During their development, NKT cells are polarized into the NKT1, NKT2, and NKT17 subsets, defined through their cytokine-secretion patterns and the expression of key transcription factors. However, we have largely ignored how the differentiation into the NKT cell subsets is regulated...
February 10, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28186911/differentiation-free-multiswitching-neuroadaptive-control-of-strict-feedback-systems
#15
Jeng-Tze Huang, Thanh-Phong Pham
Issues of differentiation-free multiswitching neuroadaptive tracking control of strict-feedback systems are presented. It mainly consists of a set of nominal adaptive neural network compensators plus an auxiliary switched linear controller that ensures the semiglobally/globally ultimately uniformly bounded stability when the unknown nonlinearities are locally/globally linearly bounded, respectively. In particular, the so-called explosion of complexity is annihilated in two steps. First, a set of first-order low-pass filters are constructed for solving such a problem in the nominal neural compensators...
February 7, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28186806/casimir-forces-and-quantum-friction-from-ginzburg-radiation-in-atomic-bose-einstein-condensates
#16
Jamir Marino, Alessio Recati, Iacopo Carusotto
We theoretically propose an experimentally viable scheme to use an impurity atom in an atomic Bose-Einstein condensate, in order to realize condensed-matter analogs of quantum vacuum effects. In a suitable atomic level configuration, the collisional interaction between the impurity atom and the density fluctuations in the condensate can be tailored to closely reproduce the electric-dipole coupling of quantum electrodynamics. By virtue of this analogy, we recover and extend the paradigm of electromagnetic vacuum forces to the domain of cold atoms, showing in particular the emergence, at supersonic atomic speeds, of a novel power-law scaling of the Casimir force felt by the atomic impurity, as well as the occurrence of a quantum frictional force, accompanied by the Ginzburg emission of Bogoliubov quanta...
January 27, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28186723/bioresponsive-dna-hydrogels-beyond-the-conventional-stimuli-responsiveness
#17
Dong Wang, Yue Hu, Peifeng Liu, Dan Luo
Bioresponsive hydrogels can respond to various biological stimuli by a macroscopic change of physical state or by converting biochemical inputs into biological or mechanical outputs. These materials are playing an increasingly important role in a wide variety of applications, especially in the biological and biomedical fields. However, the design and engineering of intriguing bioresponsive materials with adequate biocompatibility and biodegradability have proven to be a great challenge. DNA, on the other hand, possesses many unique and fascinating properties, including its indispensable genetic function, broad biocompatibility, precise molecular recognition capability, tunable multifunctionality, and convenient programmability...
February 10, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28182989/6-cyclohexylmethyl-3-hydroxypyrimidine-2-4-dione-as-an-inhibitor-scaffold-of-hiv-reverase-transcriptase-impacts-of-the-3-oh-on-inhibiting-rnase-h-and-polymerase
#18
Jing Tang, Karen A Kirby, Andrew D Huber, Mary C Casey, Juan Ji, Daniel J Wilson, Stefan G Sarafianos, Zhengqiang Wang
3-Hydroxypyrimidine-2,4-dione (HPD) represents a versatile chemical core in the design of inhibitors of human immunodeficiency virus (HIV) reverse transcriptase (RT)-associated RNase H and integrase strand transfer (INST). We report herein the design, synthesis and biological evaluation of an HPD subtype (4) featuring a cyclohexylmethyl group at the C-6 position. Antiviral testing showed that most analogues of 4 inhibited HIV-1 in the low nanomolar to submicromolar range, without cytotoxicity at concentrations up to 100 μM...
January 30, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28177982/pharmacological-activation-of-protein-kinase-a-improves-memory-loss-and-neuropathological-changes-in-a-mouse-model-of-dementia-of-alzheimer-s-type
#19
Amit Kumar, Nirmal Singh
The study investigates the therapeutic potential of the protein kinase A (PKA) activator forskolin in cognitive deficits of mice. Streptozotocin (STZ) [3 mg/kg, intracerebroventricularly (i.c.v.)] was used to induce memory deficits in mice, whereas aged mice served as natural model of dementia. Forskolin (2.5, 5, and 10 mg/kg/day, oral) treatment was administered to i.c.v. STZ-treated and aged mice for 14 days. The Morris Water Maze test was used to evaluate learning and memory. Estimation of brain acetylcholinesterase (AChE) activity, brain glutathione, thiobarbituric acid-reactive species, brain myeloperoxidase levels, and histopathological studies were also performed...
February 7, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/28174746/the-farnesoid-x-receptor-good-for-bad
#20
REVIEW
Stephen J Keely, Julian R F Walters
Diarrhea is a feature of several chronic intestinal disorders that are associated with increased delivery of bile acids into the colon. Although the prevalence of bile acid diarrhea is high, affecting approximately 1% of the adult population, current therapies often are unsatisfactory. By virtue of its capacity to inhibit colonic epithelial fluid secretion and to down-regulate hepatic bile acid synthesis through induction of the ileal fibroblast growth factor 19 release, the nuclear bile acid receptor, farnesoid X receptor, represents a promising target for the development of new therapeutic approaches...
November 2016: Cellular and Molecular Gastroenterology and Hepatology
keyword
keyword
19172
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"