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https://www.readbyqxmd.com/read/28545774/integrating-faith-based-and-community-based-participatory-research-approaches-to-adapt-the-korean-parent-training-program
#1
Eunjung Kim, Doris Boutain, Sangho Kim, Jin-Joo Chun, Hyesang Im
PUEPOSE: Faith and community based inquiry approaches are rarely used to develop research interventions. The purpose of this article is to present how a research team worked with six Korean American Christian churches to revise the prototype Korean Parent Training Program (KPTP), based upon the Bright Futures Parenting Program. The collaboration was sought to better integrate and align the KPTP with Korean culture and faith. The KPTP was developed to promote positive parenting practices and decrease mental health disparities of Korean American children...
May 22, 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28545463/cve-an-r-package-for-interactive-variant-prioritisation-in-precision-oncology
#2
Andreas Mock, Suzanne Murphy, James Morris, Francesco Marass, Nitzan Rosenfeld, Charlie Massie
BACKGROUND: An increasing number of precision oncology programmes are being launched world-wide. To support this development, we present the Cancer Variant Explorer (CVE), an R package with an interactive Shiny web browser interface. RESULTS: Leveraging Oncotator and the Drug Gene Interaction Database, CVE offers exploration of variants within single or multiple tumour exomes to identify drivers, resistance mechanisms and to assess druggability. We present example applications including the analysis of an individual patient and a cohort-wide study, and provide a first extension of CVE by adding a tumour-specific co-expression network...
May 25, 2017: BMC Medical Genomics
https://www.readbyqxmd.com/read/28544295/citation-indices-for-social-media-articles-in-urology
#3
Ross J S Calopedos, Cindy Garcia, Prem Rashid, Declan G Murphy, Nathan Lawrentschuk, Henry H Woo
OBJECTIVE: To evaluate the impact of publications on urological participation in social media (SoMe) by virtue of citations in the urological and non-urological literature. MATERIALS AND METHODS: On 15 March 2016, a PubMed search was undertaken using the names of the major SoMe platforms in current use and associated with the field of urology. The search term 'urolog*' was used to specifically capture articles that could be associated with 'urology', 'urologist' or 'urological'...
May 2017: BJU International
https://www.readbyqxmd.com/read/28543658/the-virtues-of-national-ethics-committees
#4
Jonathan Montgomery
The United Kingdom has many bodies that play their part in carrying out the work of national ethics committees, but its nearest equivalent of a U.S. presidential bioethics commission is the Nuffield Council on Bioethics, established in 1991. The Council is charged with examining ethical questions raised by developments in biological and medical research, publishing reports, and making representations to appropriate bodies in order to respond to or anticipate public concern. It is a nongovernment organization with no defined or guaranteed channels of influence...
May 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28541893/sequential-optimization-for-efficient-high-quality-object-proposal-generation
#5
Ziming Zhang, Yun Liu, Xi Chen, Yanjun Zhu, Ming-Ming Cheng, Venkatesh Saligrama, Philip H S Torr
We are motivated by the need for a generic object proposal generation algorithm which achieves good balance between object detection recall, proposal localization quality and computational efficiency. We propose a novel object proposal algorithm, BING++, which inherits the virtue of good computational efficiency of BING [1] but significantly improves its proposal localization quality. At high level we formulate the problem of object proposal generation from a novel probabilistic perspective, based on which our BING++ manages to improve the localization quality by employing edges and segments to estimate object boundaries and update the proposals sequentially...
May 23, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28541534/effect-of-maternal-obesity-on-placental-lipid-metabolism
#6
Virtu Calabuig-Navarro, Maricela Haghiac, Judi Minium, Patricia Glazebrook, Geraldine Cheyana Ranasinghe, Charles Hoppel, Sylvie Hauguel de-Mouzon, Patrick Catalano, Perrie O'Tierney-Ginn
Obese women, on average, give birth to babies with high fat mass. Placental lipid metabolism alters fetal lipid delivery, potentially moderating neonatal adiposity, yet how it is affected by maternal obesity is poorly understood. We hypothesized that fatty acid (FA) accumulation (esterification) is higher, and FA oxidation (FAO) is lower, in placentas from obese, compared to lean women. We assessed acylcarnitine profiles (lipid oxidation intermediates) in mother-baby-placenta triads, in addition to lipid content, and mRNA/protein expression of key regulators of FA metabolism pathways, in placentas of lean and obese women with normal glucose tolerance recruited at scheduled term Cesarean delivery...
May 23, 2017: Endocrinology
https://www.readbyqxmd.com/read/28539753/maximum-principle-for-a-stochastic-delayed-system-involving-terminal-state-constraints
#7
Jiaqiang Wen, Yufeng Shi
We investigate a stochastic optimal control problem where the controlled system is depicted as a stochastic differential delayed equation; however, at the terminal time, the state is constrained in a convex set. We firstly introduce an equivalent backward delayed system depicted as a time-delayed backward stochastic differential equation. Then a stochastic maximum principle is obtained by virtue of Ekeland's variational principle. Finally, applications to a state constrained stochastic delayed linear-quadratic control model and a production-consumption choice problem are studied to illustrate the main obtained result...
2017: Journal of Inequalities and Applications
https://www.readbyqxmd.com/read/28535683/electrocatalytic-c-h-n-h-coupling-of-2-aminoacetophenones-for-the-synthesis-of-isatins
#8
Peng Qian, Ji-Hu Su, Yukang Wang, Meixiang Bi, Zhenggen Zha, Zhiyong Wang
2'-Aminoacetophenones undergo a C(sp3)-H oxidation and a following intramolecular C-N bond formation by virtue of a simply electrochemical oxidation in the presence of n-Bu4NI, providing various isatins with moderate to good yields. The reaction intermediates were detected, and a radical-based pathway was proposed.
May 24, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28535173/invited-commentary-self-control-is-a-virtue
#9
C R Weinberg
The case-crossover design, introduced in 1991 by Malcolm Maclure (Am J Epidemiol. 1991;133(2):144-153), provided a precise and powerful tool for studying short-term effects of transient triggering exposures on abrupt outcomes like myocardial infarction. The design is an example of "self-control." One compares case-time intervals that include experiences that came just before the health event with control-time intervals that capture comparable experiences more remote from the event. Methodologists have since tweaked the general approach, recognizing issues that need to be considered to guard against time-driven confounders...
May 23, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28533107/ehs-matrix-incubated-in-media-containing-penicillin-retains-sufficient-concentrations-of-antibiotic-to-inhibit-growth-of-susceptible-microorganisms
#10
Mark P Murphy, Dagmara A Niedziela, Orla M Keane
In studying the interaction between bacteria and host cells in vitro, the latter are frequently cultured on commercially available biotic matrices such as Matrigel® or Geltrex®. To avoid contamination, host cells are commonly grown in the presence of antibiotics. However, we present here the finding that cell culture on such a matrix in the presence of antibiotics interferes with the outcome of subsequent infection experiments by virtue of diminished bacterial survival. By comparing outcomes for penicillin-susceptible and resistant strains of Staphylococcus aureus, we show that residual penicillin remains in the matrix despite the antibiotics' withdrawal from culture...
May 19, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28532548/mtorc1-in-agrp-neurons-integrates-exteroceptive-and-interoceptive-food-related-cues-in-the-modulation-of-adaptive-energy-expenditure-in-mice
#11
Luke K Burke, Tamana Darwish, Althea R Cavanaugh, Sam Virtue, Emma Roth, Joanna Morro, Shun-Mei Liu, Jing Xia, Jeffrey W Dalley, Keith Burling, Streamson Chua, Toni Vidal-Puig, Gary J Schwartz, Clémence Blouet
Energy dissipation through interscapular brown adipose tissue (iBAT) thermogenesis is an important contributor to adaptive energy expenditure. However, it remains unresolved how acute and chronic changes in energy availability are detected by the brain to adjust iBAT activity and maintain energy homeostasis. Here, we provide evidence that AGRP inhibitory tone to iBAT represents an energy-sparing circuit that integrates environmental food cues and internal signals of energy availability. We establish a role for the nutrient-sensing mTORC1 signaling pathway within AGRP neurons in the detection of environmental food cues and internal signals of energy availability, and in the bi-directional control of iBAT thermogenesis during nutrient deficiency and excess...
May 23, 2017: ELife
https://www.readbyqxmd.com/read/28529775/crystal-structure-and-hirshfeld-surface-analysis-of-the-new-cyclo-diphosphazane-etnp-s-nme2-2
#12
Chokri Issaoui, Hammouda Chebbi, Khaled Alouani, Abderrahmen Guesmi
The cyclic compound 2,4-bis(dimethylamino)-1,3-diethylcyclodiphosphazane-2,4-dithione [systematic name: 2,4-bis(dimethylamino)-1,3-diethyl-1,3,2λ(5),4λ(5)-diazadiphosphetidine-2,4-dithione], C8H22N4P2S2 or [EtNP(S)NMe2]2, is member of a class of mol-ecules that may be used, by virtue of their complexation properties, for the extraction of metals. This compound was characterized in solution by ((1)H and (31)P) NMR, and in the solid state by energy-dispersive X-ray spectroscopy (EDX) and by X-ray crystallography...
May 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28527971/identification-and-comprehensive-evaluation-of-reference-genes-for-rt-qpcr-analysis-of-host-gene-expression-in-brassica-juncea-aphid-interaction-using-microarray-data
#13
Chet Ram, Murali Krishna Koramutla, Ramcharan Bhattacharya
Brassica juncea is a chief oil yielding crop in many parts of the world including India. With advancement of molecular techniques, RT-qPCR based study of gene-expression has become an integral part of experimentations in crop breeding. In RT-qPCR, use of appropriate reference gene(s) is pivotal. The virtue of the reference genes, being constant in expression throughout the experimental treatments, needs to be validated case by case. Appropriate reference gene(s) for normalization of gene-expression data in B...
May 11, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28517942/cognitive-bias-and-paw-preference-in-the-domestic-dog-canis-familiaris
#14
Deborah L Wells, Peter G Hepper, Adam D S Milligan, Shanis Barnard
Limb use, an indicator of hemispheric functioning, may be a useful predictor of cognitive bias and hence vulnerability to welfare risk. The relationship between cognitive bias and motor asymmetry, however, has been subject to little investigation. This study explored the association between motor asymmetry and cognitive bias in the domestic dog, a species that displays lateral bias in the form of paw preferences and exhibits positive and negative affective states. Thirty pet dogs had their paw preferences assessed using the Kong ball test...
May 18, 2017: Journal of Comparative Psychology
https://www.readbyqxmd.com/read/28516759/reduced-graphene-oxide-wrapped-nickel-rich-cathode-materials-for-lithium-ion-batteries
#15
Jae-Hyun Shim, Young-Min Kim, Miji Park, Jongsik Kim, Sanghun Lee
The encapsulation of Ni-rich cathode materials (LiNi0.6Co0.2Mn0.2O2) for lithium ion batteries in reduced graphene oxide (rGO) sheets is introduced to improve electrochemical performances. Using (3-aminopropyl)triethoxysilane, the active materials are completely wrapped with several rGO layers of ~2 nm thickness. By virtue of the great electrical conductivity of graphene, the rGO-coated cathode materials exhibit much enhanced electrochemical performances of cycling property and rate capability. In addition, it is shown that the structural degradation of the active materials, which is from the rhombohedral layered structure (R-3 m) to the spinel (Fd-3 m) or rock-salt phase (Fm-3 m), is significantly reduced as well as delayed due to the protection of the active materials in the rGO layers from direct contact with electrolytes and the consequent suppression of side reactions...
May 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28516397/perspective-of-islamic-self-rethinking-ibn-al-qayyim-s-three-heart-model-from-the-scope-of-dynamical-social-psychology
#16
Walid Briki, Mahfoud Amara
The present article proposes the perspective of Islamic self (PIS), which is guided by three core principles. First, the Islamic self is shaped by the God's predicament: The life test. Second, the structure of the self and its spiritual virtues represent means to succeed the life test. Third, the complex dynamics of the self can be mathematically formalized into a parsimonious framework. Specifically, the PIS considers the self as a dynamical system characterized by the emergence of self-organized stable and unstable patterns taking the form of positive ("illuminating heart") or negative ("darkened heart") dynamics...
May 17, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/28511767/finding-the-virtue-in-virtual-care
#17
Zachary Hafner
It's going to take a lot of work. The good news is that great progress is already being made. As technology and consumer expectations continue to evolve, we can expect virtual care to play an increasingly important role in ushering in truly integrated care.
April 2017: Managed Care
https://www.readbyqxmd.com/read/28504862/poly-adenine-modulated-dna-conformation-monitored-with-sers-on-multibranched-gold-nanoparticle-and-its-sensing-application
#18
Huangxian Ju, Jingxing Guo, Yunlong Chen, Yongjia Jiang
This work proposes a facile way to modulate the conformation of DNA from "Lie Down" to "Stand Up" on the surface of multibranched gold nanoparticles (AuNS), which is realized by regulating the length of polyA linked to the DNA sequence and/or the hybridization of this sequence with target DNA, and can be monitored with Raman signal owing to the excellent performance of AuNS as SERS substrate and the distance change between Raman reporter and the substrate. The probable mechanism that depends on the repulsion of polyA to the sequence and the tip assembly has been also raised by theoretical simulation with finite difference time domain method...
May 15, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28502789/supported-lipid-bilayer-platforms-to-probe-cell-mechanobiology
#19
REVIEW
Roxanne Glazier, Khalid Salaita
Mammalian and bacterial cells sense and exert mechanical forces through the process of mechanotransduction, which interconverts biochemical and physical signals. This is especially important in contact-dependent signaling, where ligand-receptor binding occurs at cell-cell or cell-ECM junctions. By virtue of occurring within these specialized junctions, receptors engaged in contact-dependent signaling undergo oligomerization and coupling with the cytoskeleton as part of their signaling mechanisms. While our ability to measure and map biochemical signaling within cell junctions has advanced over the past decades, physical cues remain difficult to map in space and time...
May 11, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28502222/understanding-pain-physiology-and-its-application-to-person-with-intellectual-disability
#20
Owen Doody, Maria E Bailey
The issue of pain warrants attention as, by virtue of having an intellectual disability, a person may have associated medical or physical conditions and associated factors increasing their risk of pain disorders. People with intellectual disability experiencing pain need to be provided with the best possible care. The focus of this article is on the exploration of pain: physiology and types; manifestations and responses in the context of intellectual disability in order to promote effective, knowledgeable assessment and management of pain for this client group...
January 1, 2017: Journal of Intellectual Disabilities: JOID
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