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https://www.readbyqxmd.com/read/28640741/an-endophytic-fusarium-sp-isolated-from-monarda-citriodora-produces-the-industrially-important-plant-like-volatile-organic-compound-hexanal
#1
Meenu Katoch, Kushal Bindu, Shipra Phull, M K Verma
An endophytic fungus, MC_25L, has been isolated from the leaves of MonardacitriodoraCerv. ex Lag., a medicinal and aromatic herb from the northwestern Himalayas. It produces a fruity fragrance while growing on potato dextrose agar, suggesting that it is producing volatile organic compounds (VOCs). The endophyte inhibited the growth of plant pathogens such asSclerotiniasp. and Aspergillusflavus by virtue of VOCs. Identification of MC_25L based on morphological and microscopic features, as well as ITS-based rDNA sequence analysis, revealed that it is a Fusariumsp...
June 22, 2017: Microbiology
https://www.readbyqxmd.com/read/28637198/multi-target-activity-of-hemidesmus-indicus-decoction-against-innovative-hiv-1-drug-targets-and-characterization-of-lupeol-mode-of-action
#2
Francesca Esposito, Manuela Mandrone, Claudia Del Vecchio, Ilaria Carli, Simona Distinto, Angela Corona, Mariacaterina Lianza, Dario Piano, Massimo Tacchini, Elias Maccioni, Filippo Cottiglia, Elisa Saccon, Ferruccio Poli, Cristina Parolin, Enzo Tramontano
Despite the availability of several anti-retrovirals there is still an urgent need for developing novel therapeutic strategies and finding new drugs against underexplored HIV-1 targets. Among them, there are the HIV-1 Reverse Transcriptase (RT)-associated Ribonuclease H (RNase H) function and the cellular α-glucosidase, involved in the control mechanisms of N-linked glycoproteins formation in the endoplasmic reticulum. It is known that many natural compounds, such as pentacyclic triterpenes, are a promising class of HIV-1 inhibitors...
June 20, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28629978/dual-roles-of-tpgs-based-microemulsion-for-tacrolimus-enhancing-the-percutaneous-delivery-and-anti-psoriatic-efficacy
#3
Tao Wan, Jingtong Pan, Yueming Long, Kaiyue Yu, Yixuan Wang, Wenhui Pan, Wenyi Ruan, Mengyao Qin, Chuanbin Wu, Yuehong Xu
In this study, we demonstrate for the first time the dual roles of Tocopheryl Polyethylene Glycol 1000 Succinate (TPGS) based microemulsion (ME) for tacrolimus (TAC) to enhance TAC percutaneous delivery and anti-psoriatic efficacy. The ME formulation was developed and optimized based on pseudo-ternary phase diagrams combined with in vitro permeation. The result of Fourier transform infrared spectroscopy (FTIR) demonstrated that TAC was completely solubilized in the TPGS-ME. In vitro permeation studies showed that TPGS-ME enhanced TAC permeation through and into the skin, and the enhanced deposition of TAC in the normal or psoriatic skin was further confirmed in vivo...
June 16, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28629020/a-comparative-in-vivo-evaluation-of-bioactive-glasses-and-bioactive-glass-based-composites-for-bone-tissue-repair
#4
Devis Bellucci, Alexandre Anesi, Roberta Salvatori, Luigi Chiarini, Valeria Cannillo
In this work a set of novel materials for bone tissue regeneration have been tested in vivo in an animal model. In fact, despite many studies have been devoted to amorphous 45S5 Bioglass®, there is lack in the literature of works aimed to study the in vivo performance of heat-treated - and thus partially crystallized - 45S5. As widely reported, crystallization limits the bioactivity of 45S5 and is the main reason that prevents a broader use of this material. Thus, in the present work, a recently developed bioactive glass (BG_Ca/Mix) is tested, since previous investigations demonstrated that BG_Ca/Mix is particularly promising by virtue of both its high bioactivity and lower tendency to crystallize with respect to 45S5...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28628326/improved-sodium-ion-storage-performance-of-ultrasmall-iron-selenide-nanoparticles
#5
Feipeng Zhao, Sida Shen, Liang Cheng, Lu Ma, Junhua Zhou, Hualin Ye, Na Han, Tianpin Wu, Yanguang Li, Jun Lu
Sodium-ion batteries are potential low-cost alternatives to current lithium-ion technology, yet their performance still fall short of expectation due to the lack of suitable electrode materials with large capacity, long-term cycling stability and high-rate performance. In this work, we demonstrated that ultrasmall (~5 nm) iron selenide (FeSe2) nanoparticles exhibited a remarkable performance for sodium-ion storage. They were prepared from a high-temperature solution method with a narrow size distribution and high yield, and could be readily redispersed in non-polar organic solvents...
June 19, 2017: Nano Letters
https://www.readbyqxmd.com/read/28627766/recent-applications-of-metal-organic-frameworks-in-sample-pretreatment
#6
Yonghua Wang, Min Rui, Guanghua Lu
Metal-organic frameworks are promising materials in diverse analytical applications especially in sample pretreatment by virtue of their diverse structure topology, tunable pore size, permanent nanoscale porosity, high surface area and good thermostability. According to hydrostability, metal-organic frameworks are divided into moisture-sensitive and water-stable types. In the actual application, both kinds of metal organic frameworks are usually engineered into hybrid composites containing magnetite, silicon dioxide, graphene or directly carbonized to metal-organic-frameworks-derived carbon...
June 19, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28625541/plant-derived-antifungal-compounds-trigger-a-common-transcriptional-response
#7
Zhe Wang
Understanding the mechanism of action of antifungal drugs is vital for better control of mycosis, which kills >1.3 million lives every year thus remains a major health problem worldwide. In this study, we investigate the activities of three different categories of plant-derived antifungal compounds (resveratrol, honokiol and osthole) via transcriptomics and bioinformatics analysis, with the goal of discovering the common Mode-of-Action (MoA) at molecular level. The result shows that a common transcriptional response (72 gene are up-regulated while 10 genes are down-regulated, commonly) are triggered by above representative antifungal compounds in Schizosaccharomyces pombe (S...
June 15, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28624816/circulating-micrornas-as-potential-biomarkers-for-coronary-plaque-rupture
#8
Sufang Li, Chongyou Lee, Junxian Song, Changlin Lu, Jun Liu, Yuxia Cui, Huizhu Liang, Chengfu Cao, Feng Zhang, Hong Chen
Coronary plaque rupture is the most common cause of acute coronary syndrome. However, the timely biomarker-based diagnosis of plaque rupture remains a major unmet clinical challenge. Balloon dilatation and stent implantation during percutaneous coronary intervention (PCI) could cause plaque injury and rupture. Here we aimed to assess the possibility of circulating microRNAs (miRNAs) as biomarkers of acute coronary plaque rupture by virtue of the natural model of PCI-induced plaque rupture. Stable coronary artery disease patients underwent PCI with single stent implantation were recruited and a three-phase approach was conducted in the present study: (i) profiling of plasma miRNAs in a group of patients before (0 h) and after balloon dilatation for 1 h (1 h vs...
May 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28622617/determination-and-pharmacokinetics-of-engeletin-in-rat-plasma-by-ultra-high-performance-liquid-chromatography-with-tandem-mass-spectrometry
#9
Weijian Ye, Ruijie Chen, Wei Sun, Chengke Huang, Xixi Lin, Yaoyao Dong, Congcong Wen, Xianqin Wang
Engeletin, a bioactive flavonoid, has attracted much attention recently by virtue of its multiple biological (anti-diabetic and anti-inflammatory) activities. Despite signifying many therapeutic applications researches indicating quantification or pharmacokinetics of engeletin in biological matrix are still lacking. Here, a simple, sensitive, accurate and reliable ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) approach for the quantification of engeletin in rat plasma was developed and fully validated for the first time...
June 10, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28622010/-are-you-in-or-are-you-out-moral-appeals-to-the-public-in-organ-donation-poster-campaigns-a-multimodal-and-ethical-analysis
#10
Solveig L Hansen, Marthe I Eisner, Larissa Pfaller, Silke Schicktanz
Organ transplantation is a well-established practice in modern medicine. However, many countries, especially those with an opt-in regulation, face the problem of low donation numbers. Respective public campaigns attempt to increase the number of donors by swaying public opinion with the use of carefully selected bits of information. Germany serves as a case study for an opt-in country investing approximately €7.5 million/year in the distribution of respective campaigns. To address diverse populations, large-scale posters in various public spaces still display a multitude of moral messages for organ donation...
June 16, 2017: Health Communication
https://www.readbyqxmd.com/read/28621947/cucurbit-7-uril-enables-multi-stimuli-responsive-release-from-the-self-assembled-hydrophobic-phase-of-a-metal-organic-polyhedron
#11
Soumen K Samanta, Jeffrey Quigley, Brittany Vinciguerra, Volker Briken, Lyle Isaacs
Mixed self-assembly of ligands 1, 2, 1,6-hexanediamine (HDA), and Pd(NO3)2 afforded Fujita-type metal organic polyhedron MOP1 (diameter ≈ 8.2 nm), which is covalently functionalized with an average of 18 cucurbit[7]uril (CB[7]) units, as evidenced by (1)H NMR, diffusion-ordered spectroscopy NMR, and transmission electron microscopy measurements. By virtue of the host-guest properties of CB[7], the inner cavity of MOP can be rendered hydrophobic by using octadecyl HDA (3) as guest during the self-assembly process...
June 23, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28621232/paving-the-path-for-invasion-the-polyedric-role-of-lasp1-in-cancer
#12
REVIEW
Vitalba Ruggieri, Francesca Agriesti, Tiziana Tataranni, Roberto Perris, Domenica Mangieri
Although usually referred to as a structural actin-binding protein, LIM and SH3 domain-containing protein may actually be dynamically involved in the control of a wide spectrum of cellular processes, by virtue of its interaction with several molecular partners. Alongside being ubiquitously expressed in physiological conditions, LIM and SH3 domain-containing protein is overexpressed in a growing number of human cancers, in which it may actively contribute to their aggressiveness by promoting cell proliferation and migration...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28618933/high-expression-of-long-non-coding-rna-zeb1-as1-promotes-colorectal-cancer-cell-proliferation-partially-by-suppressing-p15-expression
#13
Huangbo Gong, Hao Wen, Xuhui Zhu, Yifan Lian, Xiaojun Yang, Zhuyin Qian, Jin Zhu
This study aims to investigate the function of long non-coding RNA ZEB1-AS1, reveal its molecular mechanism in colorectal cancer cell growth, and evaluate its clinical significance in colorectal cancer patients. ZEB1-AS1 has reported in the development of several cancers, but the biological role of it in colorectal cancer has not been discussed. In this report, ZEB1-AS1 expression level was measured with quantitative real-time polymerase chain reaction in 63 pairs of colorectal cancer tissues and paired adjacent non-tumor colorectal tissues...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28616348/predictive-risk-models-for-proximal-aortic-surgery
#14
REVIEW
Daniel Hernandez-Vaquero, Rocío Díaz, Isaac Pascual, Rubén Álvarez, Alberto Alperi, Jose Rozado, Carlos Morales, Jacobo Silva, César Morís
Predictive risk models help improve decision making, information to our patients and quality control comparing results between surgeons and between institutions. The use of these models promotes competitiveness and led to increasingly better results. All these virtues are of utmost importance when the surgical operation entails high-risk. Although proximal aortic surgery is less frequent than other cardiac surgery operations, this procedure itself is more challenging and technically demanding than other common cardiac surgery techniques...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28615993/resveratrol-protects-against-icv-collagenase-induced-neurobehavioral-and-biochemical-deficits
#15
Navdeep Singh, Yashika Bansal, Ranjana Bhandari, Lovish Marwaha, Raghunath Singh, Kanwaljit Chopra, Anurag Kuhad
BACKGROUND: Indeed, intracerebral hemorrhage (ICH) account for only 15% of all strokes but it is one of the most devastating subtype of stroke associated with behavioral, cognitive and neurological deficits. The primary cause of neurological deficits in ICH is the hematoma growth, generation of free radicals, inflammatory cytokines and exhausting endogenous anti-oxidant machinery. It has been found that neuroinflammation following ICH leads to exaggeration of hallmarks of ICH. With this background, the study was aimed to evaluate the protective effect of resveratrol (RSV) in intracerebroventricular (ICV) collagenase (COL) induced neurological deficits in rats...
2017: Journal of Inflammation
https://www.readbyqxmd.com/read/28613874/distinguishing-cis-and-trans-isomers-in-intact-complex-lipids-using-electron-impact-excitation-of-ions-from-organics-eieio-mass-spectrometry
#16
Takashi Baba, J Larry Campbell, J C Yves Le Blanc, Paul R S Baker
We present a mass spectrometry-based method for the identification of cis and trans double bond isomers within intact complex lipid mixtures using Electron Impact Excitation of Ions from Organics (EIEIO) mass spectrometry. EIEIO involves irradiating singly charged lipid ions with electrons having kinetic energies of 5-16 eV. The resulting EIEIO spectra can be used to discern cis and trans double bond isomers by virtue of the differences in the fragmentation patterns at the carbon-carbon single bonds neighboring the double bonds...
June 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28613808/sensitivity-enhanced-wearable-active-voiceprint-sensor-based-on-cellular-polypropylene-piezoelectret
#17
Wenbo Li, Sheng Zhao, Nan Wu, Junwen Zhong, Bo Wang, Shizhe Lin, Shuwen Chen, Fang Yuan, Hulin Jiang, Yongjun Xiao, Bin Hu, Jun Zhou
Wearable active sensors have extensive applications in mobile biosensing and human-machine interaction but require good flexibility, high sensitivity, excellent stability and self-powered feature. In this work, cellular polypropylene (PP) piezoelectret was chosen as the core material of a sensitivity-enhanced wearable active voiceprint sensor (SWAVS) to realize voiceprint recognition. By virtue of dipole orientation control method, the air layers in piezoelectret were efficiently utilized and the current sensitivity was enhanced (from 1...
June 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28609743/facile-synthesis-of-self-assembled-ultrathin-%C3%AE-feooh-nanorod-graphene-oxide-composites-for-supercapacitors
#18
Yuxue Wei, Ruimin Ding, Chenghua Zhang, Baoliang Lv, Yi Wang, Chengmeng Chen, Xiaoping Wang, Jian Xu, Yong Yang, Yongwang Li
A one-pot facile, impurity-free hydrothermal method to synthesize ultrathin α-FeOOH nanorods/graphene oxide (GO) composites is reported. It is directly synthesized from GO and iron acetate in water solution without inorganic or organic additives. XRD, Raman, FT-IR, XPS and TEM are used to characterize the samples. The nanorods in composites are single crystallite with an average diameter of 6nm and an average length of 75nm, which are significantly smaller than GO-free α-FeOOH nanorods. This can be attributed to the confinement effect and special electronic influence of GO...
May 31, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28604657/in-beam-measurement-of-the-hydrogen-hyperfine-splitting-and-prospects-for-antihydrogen-spectroscopy
#19
M Diermaier, C B Jepsen, B Kolbinger, C Malbrunot, O Massiczek, C Sauerzopf, M C Simon, J Zmeskal, E Widmann
Antihydrogen, the lightest atom consisting purely of antimatter, is an ideal laboratory to study the CPT symmetry by comparison with hydrogen. With respect to absolute precision, transitions within the ground-state hyperfine structure (GS-HFS) are most appealing by virtue of their small energy separation. ASACUSA proposed employing a beam of cold antihydrogen atoms in a Rabi-type experiment, to determine the GS-HFS in a field-free region. Here we present a measurement of the zero-field hydrogen GS-HFS using the spectroscopy apparatus of ASACUSA's antihydrogen experiment...
June 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/28602507/designed-synthesis-of-ultra-hydrophilic-sulfo-functionalized-metal-organic-frameworks-with-a-magnetic-core-for-highly-efficient-enrichment-of-the-n-linked-glycopeptides
#20
Yiqin Xie, Chunhui Deng, Yan Li
Highly efficient extraction and enrichment of the N-linked glycopeptides from complex biological samples before mass spectrometry analysis remains important but challenging, due to the low abundance and suppression by proteins and salts. Herein, a facile route to an ultra-hydrophilic metal-organic frameworks (MOFs)-functionalized magnetic nanoparticle (Fe3O4@PDA@Zr-SO3H) was proposed. The as-prepared MOFs was endowed with excellent and unique properties, such as excellent hydrophilicity, ultrahigh surface area, and strong magnetic responsiveness...
May 26, 2017: Journal of Chromatography. A
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