keyword
https://read.qxmd.com/read/38528599/local-alternating-heat-and-cold-stimulation-affects-hemodynamics-and-oxygenation-in-fatigued-muscle-tissue-and-autonomic-nervous-activity-a-single-arm-interventional-study
#21
JOURNAL ARTICLE
Tomonori Sawada, Hiroki Okawara, Daisuke Nakashima, Kentaro Aoki, Mira Namba, Shuhei Iwabuchi, Yoshinori Katsumata, Masaya Nakamura, Takeo Nagura
BACKGROUND: Local alternating heat and cold stimulation as an alternative to contrast bath may cause intermittent vasoconstriction and vasodilation, inducing a vascular pumping effect and consequently promoting increased tissue blood flow and oxygenation. This study aimed to examine the effects of local alternating heat and cold stimulation, using a wearable thermal device, on the hemodynamics of fatigued muscle tissue and autonomic nervous activity. METHODS: Twenty healthy individuals experienced fatigue in the periarticular muscles of the shoulder joint due to a typing task...
March 25, 2024: Journal of Physiological Anthropology
https://read.qxmd.com/read/38527737/dietary-methionine-enhances-portal-appearance-of-guanidinoacetate-and-synthesis-of-creatine-in-yucatan-miniature-piglets
#22
JOURNAL ARTICLE
Mahesha U Asiriwardhana, O Chandani Dinesh, Janet A Brunton, Robert F Bertolo
BACKGROUND: Creatine plays a significant role in energy metabolism and positively impacts anaerobic energy capacity, muscle mass, and physical performance. Endogenous creatine synthesis requires guanidinoacetic acid (GAA) and methionine. GAA can be an alternative to creatine supplements and has been tested as a beneficial feed additive in the animal industry. When pigs are fed GAA with excess methionine, creatine is synthesized without feedback regulation. In contrast, when dietary methionine is limiting, creatine synthesis is limited, yet GAA does not accumulate in plasma, urine, or liver...
March 23, 2024: Journal of Nutrition
https://read.qxmd.com/read/38526971/protective-effects-of-human-urinary-kallidinogenase-against-corticospinal-tract-damage-in-acute-ischemic-stroke-patients
#23
JOURNAL ARTICLE
Peifang Li, Honglin Lu, Xiaoman Shi, Jiajia Yan, Lixia Zhou, Jipeng Yang, Binbin Wang, Yanying Zhao, Luji Liu, Yipu Zhu, Lei Xu, Xiaoli Yang, Xudong Su, Yi Yang, Tong Zhang, Li Guo, Xiaoyun Liu
This study aimed to assess the effects of human urinary kallidinogenase (HUK) on motor function outcome and corticospinal tract recovery in patients with acute ischemic stroke (AIS). This study was a randomized, controlled, single-blinded trial. Eighty AIS patients were split into two groups: the HUK and control groups. The HUK group was administered HUK and standard treatment, while the control group received standard treatment only. At admission and discharge, the National Institutes of Health Stroke Scale (NIHSS), Barthel Index (BI) and muscle strength were scored...
March 12, 2024: Neuroreport
https://read.qxmd.com/read/38526943/effects-of-finger-pinch-motor-imagery-on-short-latency-afferent-inhibition-and-corticospinal-excitability
#24
JOURNAL ARTICLE
Kento Nakashoji, Atsushi Sasaki, Naotsugu Kaneko, Taishin Nomura, Matija Milosevic
Motor imagery is a cognitive process involving the simulation of motor actions without actual movements. Despite the reported positive effects of motor imagery training on motor function, the underlying neurophysiological mechanisms have yet to be fully elucidated. Therefore, the purpose of the present study was to investigate how sustained tonic finger-pinching motor imagery modulates sensorimotor integration and corticospinal excitability using short-latency afferent inhibition (SAI) and single-pulse transcranial magnetic stimulation (TMS) assessments, respectively...
March 8, 2024: Neuroreport
https://read.qxmd.com/read/38526919/cxcl13-cxcr5-promote-chronic-postsurgical-pain-and-astrocyte-activation-in-rats-by-targeting-nlrp3
#25
JOURNAL ARTICLE
Hongda Yi, Bin Zhu, Caihong Zheng, Zhenyang Ying, Mei Cheng
Chronic postsurgical pain (CPSP) with high incidence negatively impacts the quality of life. X-C motif chemokine 13 (CXCL13) has been associated with postsurgery inflammation and exacerbates neuropathic pain in patients with CPSP. This study was aimed to illustrate the relationship between CXCL13 and nod-like receptor protein-3 (NLRP3), which is also involved in CPSP. A CPSP model was constructed by skin/muscle incision and retraction (SMIR) in right medial thigh, and the rats were divided into three groups: Sham, SMIR, and SMIR + anti-CXCL13 (intrathecally injected with anti-CXCL13 antibody)...
March 8, 2024: Neuroreport
https://read.qxmd.com/read/38525542/apelin-regulates-skeletal-muscle-adaptation-to-exercise-in-a-high-intensity-interval-training-hiit-model
#26
JOURNAL ARTICLE
Teemu Kilpiö, Sini Skarp, Abel Perjes, Julia Swan, Leena Kaikkonen, Samu Saarimaki, Istvan Szokodi, Josef M Penninger, Zoltan Szabo, Johanna Magga, Risto Kerkela
Plasma apelin levels are reduced in aging and muscle wasting conditions. We aimed to investigate the significance of apelin signaling in cardiac and skeletal muscle responses to physiological stress. Apelin knockout (KO) and wild type (WT) mice were subjected to high intensity interval training (HIIT) by treadmill running. The effects of apelin on energy metabolism were studied in primary mouse skeletal muscle myotubes and cardiomyocytes. Apelin increased mitochondrial ATP production and mitochondrial coupling efficiency in myotubes and promoted the expression of mitochondrial genes both in primary myotubes and cardiomyocytes...
March 25, 2024: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/38525536/skeletal-muscle-fiber-type-and-tms-induced-muscle-relaxation-in-unfatigued-and-fatigued-knee-extensor-muscles
#27
JOURNAL ARTICLE
Chiara Barbi, John Temesi, Gaia Giuriato, Fabio Giuseppe Laginestra, Camilla Martignon, Tatiana Moro, Federico Schena, Massimo Venturelli, Gianluca Vernillo
The force drop after transcranial magnetic stimulation (TMS) delivered to the motor cortex during voluntary muscle contractions could inform about muscle relaxation properties. Because of the physiological relation between skeletal muscle fiber type distribution and size and muscle relaxation, TMS could be a non-invasive index of muscle relaxation in humans. By combining a non-invasive technique to record muscle relaxation in vivo (TMS) with the gold standard technique for muscle tissue sampling (muscle biopsy), we investigated the relation between TMS-induced muscle relaxation in unfatigued and fatigued states, and muscle fiber type distribution and size...
March 25, 2024: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://read.qxmd.com/read/38525531/optimization-of-mouse-kidney-digestion-protocols-for-single-cell-applications
#28
JOURNAL ARTICLE
Jake N Robertson, Henry Diep, Alexander Pinto, Christopher G Sobey, Grant R Drummond, Antony Vinh, Maria Jelinic
Single-cell technologies such as flow cytometry and single-cell RNA sequencing (scRNAseq) have allowed for comprehensive characterisation of the kidney cellulome. However, there is disparity in the various protocols for preparing kidney single-cell suspensions. We aimed to address this limitation by characterising kidney cellular heterogeneity using three previously published single-cell preparation protocols. Single-cell suspensions were prepared from male and female C57BL/6 kidneys using the following kidney tissue dissociation protocols: (P1) a scRNAseq protocol; (P2) a multi-tissue digestion kit from Miltenyi Biotec ; and (P3) a protocol established in our laboratory...
March 25, 2024: Physiological Genomics
https://read.qxmd.com/read/38524852/stimulation-of-muscle-protein-synthesis-with-low-dose-amino-acid-composition-in-older-individuals
#29
JOURNAL ARTICLE
David D Church, Arny A Ferrando, Robert R Wolfe
Essential amino acid (EAA)-based compositions have been shown to be effective stimulators of muscle protein synthesis, but the lower limit of effective dosage is not clear. We have used stable isotope tracer methodology to quantify the response of muscle protein fractional synthetic rate (FSR) to a dose of 3.6 g of a high-leucine composition of EAAs plus arginine in older subjects. Muscle protein FSR increased 0.058%/hour over 3 h following consumption. When account was taken of the total muscle mass, this increase in muscle protein FSR represented approximately 80% of ingested EAAs...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38524827/comparison-of-nirs-exercise-intensity-thresholds-with-maximal-lactate-steady-state-critical-power-and-rowing-performance
#30
JOURNAL ARTICLE
Leonardo Trevisol Possamai, Fernando Klitzke Borszcz, Rafael Alves de Aguiar, Ricardo Dantas de Lucas, Tiago Turnes
This study aimed to compare the intensity of deoxygenated haemoglobin concentration ([HHb]) and tissue saturation index (TSI) breakpoints ([HHb]-BP and TSI-BP) with maximal lactate steady state (MLSS) and critical power (CP), and to describe their association with 2000-m rowing ergometer performance. Fourteen male rowers performed on a rowing ergometer: I) a discontinuous incremental test with 3-min stages (INC3 ); II) a continuous incremental test with 1-min stages (INC1 ); III) constant workload tests to determine MLSS; and IV) performance tests of 500 m, 1000 m, 2000 m and 6000 m to determine CP...
March 2024: Biology of Sport
https://read.qxmd.com/read/38524279/nf-kb-affects-migration-of-vascular-smooth-muscle-cells-after-treatment-with-heparin-and-ibrutinib
#31
JOURNAL ARTICLE
Nafiseh Shokri, Ghasem Ghasempour, Ali Akbar Soleimani, Mohammad Elahimanesh, Mohammad Najafi
The migration of vascular smooth muscle cells (VSMCs) is one of the most important events in the remodeling of atherosclerosis plaque. The aim of study was to investigate the role of Heparin in the VSMC migration and its association with the NF-kB, collagen 1 and collagen 3 expression levels. Moreover, the incorporation of Heparin was studied in the VSMC cultures including Betulinic acid and Ibrutinib. Twelve cell groups were cultured and treated with the Heparin, Betulinic acid and Ibrutinib based on the viability and toxicity in 24-h and 48-h periods...
July 2024: Biochemistry and Biophysics Reports
https://read.qxmd.com/read/38523521/deep-learning-based-thigh-muscle-investigation-using-mri-for-prosthetic-development-for-patients-undergoing-total-knee-replacement-tkr
#32
JOURNAL ARTICLE
Vinod Arunachalam, Kumareshan N
BACKGROUND: A prosthetic device is designed based on the quantitative analysis of muscle MRI which will improve the muscle control achieved with functional electrical stimulation/ guided robotic exoskeletons. Electromyography (EMG) provides muscle functionality information while MRI provides the physiological and functionality of muscles. The sensor feedbacks were used for the bionic prosthesis, but the length of muscle using image processing was not correlated. OBJECTIVE: To investigate and perform qualitative and quantitative assessment of thigh muscle using MRI...
March 22, 2024: Current medical imaging
https://read.qxmd.com/read/38523442/raman-spectroscopy-coupled-with-chemometrics-for-identification-of-adulteration-and-fraud-in-muscle-foods-a-review
#33
REVIEW
Haiyang Ma, Jiajun Guo, Guishan Liu, Delang Xie, Bingbing Zhang, Xiaojun Li, Qian Zhang, Qingqing Cao, Xiaoxue Li, Fang Ma, Yang Li, Guoling Wan, Yan Li, Di Wu, Ping Ma, Mei Guo, Junjie Yin
Muscle foods, valued for their significant nutrient content such as high-quality protein, vitamins, and minerals, are vulnerable to adulteration and fraud, stemming from dishonest vendor practices and insufficient market oversight. Traditional analytical methods, often limited to laboratory-scale., may not effectively detect adulteration and fraud in complex applications. Raman spectroscopy (RS), encompassing techniques like Surface-enhanced RS (SERS), Dispersive RS (DRS), Fourier transform RS (FTRS), Resonance Raman spectroscopy (RRS), and Spatially offset RS (SORS) combined with chemometrics, presents a potent approach for both qualitative and quantitative analysis of muscle food adulteration...
March 24, 2024: Critical Reviews in Food Science and Nutrition
https://read.qxmd.com/read/38522042/plasticity-changes-in-iron-homeostasis-in-hibernating-daurian-ground-squirrels-spermophilus-dauricus-may-counteract-chronically-inactive-skeletal-muscle-atrophy
#34
JOURNAL ARTICLE
Yong Kong, Rongrong Yin, Yue He, Fangyang Pan, Huajian Yang, Huiping Wang, Jie Zhang, Yunfang Gao
Disuse-induced muscular atrophy is frequently accompanied by iron overload. Hibernating animals are a natural animal model for resistance to disuse muscle atrophy. In this paper, we explored changes in skeletal muscle iron content of Daurian ground squirrels (Spermophilus dauricus) during different periods of hibernation as well as the regulatory mechanisms involved. The results revealed that compared with the summer active group (SA), iron content in the soleus muscle (SOL) decreased (- 65%) in the torpor group (TOR), but returned to normal levels in the inter-bout arousal (IBA); splenic iron content increased in the TOR group (vs...
March 24, 2024: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://read.qxmd.com/read/38522007/plasma-beta-hydroxy-beta-methylbutyrate-availability-after-enteral-administration-during-critical-illness-after-trauma-an-exploratory-study
#35
JOURNAL ARTICLE
Kym Wittholz, Amy J Bongetti, Kate Fetterplace, Marissa K Caldow, Amalia Karahalios, David P De Souza, Sheik Nadeem Elahee Doomun, Olav Rooyackers, René Koopman, Gordon S Lynch, Yasmine Ali Abdelhamid, Adam M Deane
BACKGROUND: During critical illness skeletal muscle wasting occurs rapidly. Although beta-hydroxy-beta-methylbutyrate (HMB) is a potential treatment to attenuate this process, the plasma appearance and muscle concentration is uncertain. METHODS: This was an exploratory study nested within a blinded, parallel group, randomized clinical trial in which critically ill patients after trauma received enteral HMB (3 g daily) or placebo. Plasma samples were collected at 0, 60, and 180 min after study supplement administration on day 1...
March 24, 2024: JPEN. Journal of Parenteral and Enteral Nutrition
https://read.qxmd.com/read/38521455/from-gains-to-gaps-how-selective-androgen-receptor-modulator-sarm-yk11-impact-hippocampal-function-in-silico-in-vivo-and-ex-vivo-perspectives
#36
JOURNAL ARTICLE
Mustafa Munir Mustafa Dahleh, Vandreza Cardoso Bortolotto, Silvana Peterini Boeira, Hecson Jesser Segat, Gustavo Petri Guerra, Marina Prigol
Selective Androgen Receptor Modulators (SARMs), particularly (17α,20E)-17,20-[(1-methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic-acid-methyl-ester (YK11), are increasingly popular among athletes seeking enhanced performance. Serving as an Androgen Receptor (AR) agonist, YK11 stimulates muscle growth while inhibiting myostatin. Our study delved into the impact of YK11 on the rat hippocampus, analyzing potential alterations in neurochemical mechanisms and investigating its synergistic effects with exercise (EXE), based on the strong relationship between SARM users and regular exercise...
March 21, 2024: Chemico-biological Interactions
https://read.qxmd.com/read/38521048/body-composition-and-risk-for-sarcopenia-in-transgender-women
#37
JOURNAL ARTICLE
Laura Sánchez Amador, Antonio Becerra Fernández, María Victorina Aguilar Vilas, Rosa Rodríguez Torres, María Concepción Alonso Rodríguez
OBJECTIVES: Body composition and strength of cisgender (cis) individuals are well established. However, those for transgender women (trans women) undergoing gender-affirming hormone therapy remain unclear. This study aimed to detect possible body composition and strength variations related to sarcopenia. METHODS: This was a cross-sectional comparative study of 37 trans women, 34 cis men, and 34 cis women. Body composition was measured in all individuals by bioelectrical impedance analysis; prehensile strength by dynamometry was studied in trans women...
February 19, 2024: Nutrition
https://read.qxmd.com/read/38520938/research-progress-on-the-biological-regulatory-mechanisms-of-selenium-on-skeletal-muscle-in-broilers
#38
REVIEW
Shengchen Wang, Bing Tian, Yun Hu, Tingting Li, Xiaoyan Cui, Liyang Zhang, Xugang Luo
As one of the indispensable trace elements for both humans and animals, selenium widely participates in multiple physiological processes and facilitates strong anti-inflammatory, antioxidant, and immune enhancing abilities. The biological functions of selenium are primarily driven by its presence in selenoproteins as a form of selenocysteine. Broilers are highly sensitive to selenium intake. Recent reports have demonstrated that selenium deficiency can adversely affect the quality of skeletal muscles and the economic value of broilers; the regulatory roles of several key selenoproteins (e...
March 12, 2024: Poultry Science
https://read.qxmd.com/read/38520700/low-load-resistance-exercise-with-and-without-blood-flow-restriction-which-is-more-effective-for-increasing-local-muscle-endurance-and-why
#39
JOURNAL ARTICLE
Mathias Wernbom
No abstract text is available yet for this article.
March 23, 2024: Experimental Physiology
https://read.qxmd.com/read/38520657/nutrition-considerations-for-patients-with-persistent-critical-illness-a-narrative-review
#40
REVIEW
Elizabeth Viner Smith, Kate Lambell, Oana A Tatucu-Babet, Emma Ridley, Lee-Anne Chapple
Critically ill patients experience high rates of malnutrition and significant muscle loss during their intensive care unit (ICU) admission, impacting recovery. Nutrition is likely to play an important role in mitigating the development and progression of malnutrition and muscle loss observed in ICU, yet definitive clinical trials of nutrition interventions in ICU have failed to show benefit. As improvements in the quality of medical care mean that sicker patients are able to survive the initial insult, combined with an aging and increasingly comorbid population, it is anticipated that ICU length of stay will continue to increase...
March 23, 2024: JPEN. Journal of Parenteral and Enteral Nutrition
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